Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医学専攻 幹細胞遺伝学, 教授
• Graduate School of Medicine, 医科学専攻 幹細胞遺伝学, 教授

Professional Memberships

• 日本ゲノム編集学会
• 日本がん分子標的治療学会
• 日本癌学会

Academic Degree

• 修士（農学）(東京大学)
• 博士（医学）(大阪大学)

Academic Resume (Graduate Schools)

• University of Tokyo, Graduate School of Aglicultual and Life Sciences, 修了
• Osaka University, Graduate School of Medicine, 修了

Academic Resume (Undergraduate School/Majors)

• Osaka University, Faculty of Engineering, 卒業

Research History

• From Apr. 2022, To Present

  Kyoto University, Institute for Life and Medical Sciences, Professor
• From Oct. 2018, To Mar. 2022

  Kyoto University, Institute for Frontier Life and Medical Sciences, Professor
• From Oct. 2012, To Sep. 2018

  Wellcome Sanger Institute, Group Leader
• From Oct. 2007, To Sep. 2012

  Wellcome Sanger Institute, Postdoctoral fellow
• From Apr. 2008, To Mar. 2010

  Japan Society for the Promotion of Science, 海外特別研究員
• From Apr. 2005, To Mar. 2008

  Japan Society for the Promotion of Science, 特別研究員

ID,URL

• ORCID ID

  0000-0002-3442-021X

• J-Global ID

  201801019616705378

researchmap URL

• https://researchmap.jp/kosukeyusa

Research

Research Topics, Overview of the research

• Research Topics

  The main focus of my past research was to develop genetic tools that allow us to conduct unbiased genetic screening, namely forward genetic screen. In 2014, using the CRISPR-Cas9 system, I developed a novel genetic screening method - CRISPR-KO screening. Using this screening technique, my current research focuses on understanding molecular mechanisms underlying pluripotency and cellular differentiation of human ES/iPS cells as well as growth-essential genes and drug-resistance/sensitization in cancer cells.

Research Areas

• Life sciences, Developmental biology
• Life sciences, Tumor biology
• Life sciences, Genomics
• Life sciences, Molecular biology

Papers

• B1 SINE-binding ZFP266 impedes reprogramming through suppression of chromatin opening by pioneering factors

  Daniel F Kaemena; Masahito Yoshihara; James Ashmore; Meryam Beniazza; Suling Zhao; Marten Bertenstam; Victor Olariu; Shintaro Katayama; Keisuke Okita; Simon Tomlinson; Kosuke Yusa; Keisuke Kaji

  bioRxiv, 05 Jan. 2022

  
• Author Correction: ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response (Nature Genetics, (2020), 52, 2, (187-197), 10.1038/s41588-019-0541-5)

  Sankari Nagarajan; Shalini V. Rao; Joseph Sutton; Danya Cheeseman; Shanade Dunn; Evangelia K. Papachristou; Jose-Enrique Gonzalez Prada; Dominique-Laurent Couturier; Sanjeev Kumar; Kamal Kishore; Chandra Sekhar Reddy Chilamakuri; Silvia-Elena Glont; Emily Archer Goode; Cara Brodie; Naomi Guppy; Rachael Natrajan; Alejandra Bruna; Carlos Caldas; Alasdair Russell; Rasmus Siersbæk; Kosuke Yusa; Igor Chernukhin; Jason S. Carroll

  Nature Genetics, 01 Mar. 2020

  
• Canonical BAF complex regulates the oncogenic program in human T-cell acute lymphoblastic leukemia.

  Kazunari Aoki; Mizuki Hyuga; Yusuke Tarumoto; Gohei Nishibuchi; Atsushi Ueda; Yotaro Ochi; Seiichi Sugino; Takashi Mikami; Hirokazu Kobushi; Itaru Kato; Koshi Akahane; Takeshi Inukai; Akifumi Takaori-Kondo; Junko Takita; Seishi Ogawa; Kosuke Yusa

  Blood, 03 Nov. 2023

  
• Inference of gene regulatory networks using time-series single-cell RNA-seq data with CRISPR perturbations

  Masato Ishikawa; Seiichi Sugino; Yoshie Masuda; Yusuke Tarumoto; Yusuke Seto; Nobuko Taniyama; Fumi Wagai; Yuhei Yamauchi; Yasuhiro Kojima; Hisanori Kiryu; Kosuke Yusa; Mototsugu Eiraku; Atsushi Mochizuki

  23 Aug. 2023

  
• Pharmacologic characterization of TBP1901, a prodrug form of aglycone curcumin, and CRISPR-Cas9 screen for therapeutic targets of aglycone curcumin.

  Tomoyuki Abe; Yoshihito Horisawa; Osamu Kikuchi; Hitomi Ozawa-Umeta; Atsuhiro Kishimoto; Yasuhiro Katsuura; Atsushi Imaizumi; Tadashi Hashimoto; Kotaro Shirakawa; Akifumi Takaori-Kondo; Kosuke Yusa; Tadashi Asakura; Hideaki Kakeya; Masashi Kanai

  European journal of pharmacology, 15 Nov. 2022

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• AKT-mTORC1 reactivation is the dominant resistance driver for PI3Kβ/AKT inhibitors in PTEN-null breast cancer and can be overcome by combining with Mcl-1 inhibitors.

  Shanade Dunn; Cath Eberlein; Jason Yu; Albert Gris-Oliver; Swee Hoe Ong; Urs Yelland; Natalie Cureton; Anna Staniszewska; Robert McEwen; Millie Fox; James Pilling; Philip Hopcroft; Elizabeth A Coker; Patricia Jaaks; Mathew J Garnett; Beverley Isherwood; Violeta Serra; Barry R Davies; Simon T Barry; James T Lynch; Kosuke Yusa

  Oncogene, Nov. 2022

  
• Peroxisomal membrane protein PMP34 is involved in the human papillomavirus infection pathway

  Rie Ito; Koji Kitamura; Hidenori Inohara; Kosuke Yusa; Yasufumi Kaneda; Keisuke Nimura

  Frontiers in Virology, 06 May 2022, Peer-reviewed

  
• Genome-scale CRISPR‒Cas9 screen identifies novel host factors as potential therapeutic targets for SARS-CoV-2 infection

  Madoka Sakai; Yoshie Masuda; Yusuke Tarumoto; Naoyuki Aihara; Yugo Tsunoda; Michiko Iwata; Yumiko Kamiya; Ryo Komorizono; Takeshi Noda; Kosuke Yusa; Keizo Tomonaga; Akiko Makino

  07 Mar. 2023

  
• B1 SINE-binding ZFP266 impedes mouse iPSC generation through suppression of chromatin opening mediated by reprogramming factors.

  Daniel F Kaemena; Masahito Yoshihara; Meryam Beniazza; James Ashmore; Suling Zhao; Mårten Bertenstam; Victor Olariu; Shintaro Katayama; Keisuke Okita; Simon R Tomlinson; Kosuke Yusa; Keisuke Kaji

  Nature communications, 30 Jan. 2023

  
• Genome-wide screening identifies Polycomb repressive complex 1.3 as an essential regulator of human naïve pluripotent cell reprogramming.

  Amanda J Collier; Adam Bendall; Charlene Fabian; Andrew A Malcolm; Katarzyna Tilgner; Claudia I Semprich; Katarzyna Wojdyla; Paola Serena Nisi; Kamal Kishore; Valar Nila Roamio Franklin; Bahar Mirshekar-Syahkal; Clive D'Santos; Kathrin Plath; Kosuke Yusa; Peter J Rugg-Gunn

  Science advances, 25 Mar. 2022

  
• Selective targeting of multiple myeloma cells with a monoclonal antibody recognizing the ubiquitous protein CD98 heavy chain.

  Kana Hasegawa; Shunya Ikeda; Moto Yaga; Kouki Watanabe; Rika Urakawa; Akie Iehara; Mai Iwai; Seishin Hashiguchi; Soyoko Morimoto; Fumihiro Fujiki; Hiroko Nakajima; Jun Nakata; Sumiyuki Nishida; Akihiro Tsuboi; Yoshihiro Oka; Satoshi Yoshihara; Masahiro Manabe; Hiroyoshi Ichihara; Atsuko Mugitani; Yasutaka Aoyama; Takafumi Nakao; Asao Hirose; Masayuki Hino; Shiho Ueda; Katsuto Takenaka; Takashi Masuko; Koichi Akashi; Takahiro Maruno; Susumu Uchiyama; Shinji Takamatsu; Naoki Wada; Eiichi Morii; Shushi Nagamori; Daisuke Motooka; Yoshikatsu Kanai; Yusuke Oji; Tomoyoshi Nakagawa; Noriyuki Kijima; Haruhiko Kishima; Atsuyo Ikeda; Takayuki Ogino; Yasushi Shintani; Tateki Kubo; Emiko Mihara; Kosuke Yusa; Haruo Sugiyama; Junichi Takagi; Eiji Miyoshi; Atsushi Kumanogoh; Naoki Hosen

  Science translational medicine, 16 Feb. 2022

  
• The CADM1 tumor suppressor gene is a major candidate gene in MDS with deletion of the long arm of chromosome 11.

  Marina Lafage-Pochitaloff; Bastien Gerby; Véronique Baccini; Laetitia Largeaud; Vincent Fregona; Naïs Prade; Pierre-Yves Juvin; Laura Jamrog; Pierre Bories; Sylvie Hébrard; Stéphanie Lagarde; Véronique Mansat-De Mas; Oliver M Dovey; Kosuke Yusa; George S Vassiliou; Joop H Jansen; Tobias Tekath; David Rombaut; Geneviève Ameye; Carole Barin; Audrey Bidet; John Boudjarane; Marie-Agnès Collonge-Rame; Carine Gervais; Antoine Ittel; Christine Lefebvre; Isabelle Luquet; Lucienne Michaux; Nathalie Nadal; Hélène A Poirel; Isabelle Radford-Weiss; Bénédicte Ribourtout; Steven Richebourg; Stéphanie Struski; Christine Terré; Isabelle Tigaud; Dominique Penther; Virginie Eclache; Michaela Fontenay; Cyril Broccardo; Eric Delabesse

  Blood advances, 25 Jan. 2022

  
• Measurement of the nuclear concentration of α-ketoglutarate during adipocyte differentiation by using a fluorescence resonance energy transfer-based biosensor with nuclear localization signals.

  Tomohiro Suzuki; Mayuko Hayashi; Tetsuro Komatsu; Akiko Tanioka; Masahiro Nagasawa; Kyoko Tanimura-Inagaki; Mohammad Sharifur Rahman; Shinnosuke Masuda; Kosuke Yusa; Juro Sakai; Hiroshi Shibata; Takeshi Inagaki

  Endocrine journal, 28 Dec. 2021

  
• KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements.

  Yan Zi Au; Muxin Gu; Etienne De Braekeleer; Malgorzata Gozdecka; Demetrios Aspris; Yusuke Tarumoto; Jonathan Cooper; Jason Yu; Swee Hoe Ong; Xi Chen; Konstantinos Tzelepis; Brian J P Huntly; George Vassiliou; Kosuke Yusa

  Leukemia, Apr. 2021, Peer-reviewed

  
• Minimal genome-wide human CRISPR-Cas9 library.

  Emanuel Gonçalves; Mark Thomas; Fiona M Behan; Gabriele Picco; Clare Pacini; Felicity Allen; Alessandro Vinceti; Mamta Sharma; David A Jackson; Stacey Price; Charlotte M Beaver; Oliver Dovey; David Parry-Smith; Francesco Iorio; Leopold Parts; Kosuke Yusa; Mathew J Garnett

  Genome biology, 21 Jan. 2021

  
• Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions.

  Oliver Thompson; Ferdinand von Meyenn; Zoe Hewitt; John Alexander; Andrew Wood; Richard Weightman; Sian Gregory; Felix Krueger; Simon Andrews; Ivana Barbaric; Paul J Gokhale; Harry D Moore; Wolf Reik; Marta Milo; Serena Nik-Zainal; Kosuke Yusa; Peter W Andrews

  Nature communications, 23 Mar. 2020, Peer-reviewed

  
• ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response.

  Sankari Nagarajan; Shalini V Rao; Joseph Sutton; Danya Cheeseman; Shanade Dunn; Evangelia K Papachristou; Jose-Enrique Gonzalez Prada; Dominique-Laurent Couturier; Sanjeev Kumar; Kamal Kishore; Chandra Sekhar Reddy Chilamakuri; Silvia-Elena Glont; Emily Archer Goode; Cara Brodie; Naomi Guppy; Rachael Natrajan; Alejandra Bruna; Carlos Caldas; Alasdair Russell; Rasmus Siersbæk; Kosuke Yusa; Igor Chernukhin; Jason S Carroll

  Nature genetics, Feb. 2020, Peer-reviewed

  
• Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets.

  Joshua M Dempster; Clare Pacini; Sasha Pantel; Fiona M Behan; Thomas Green; John Krill-Burger; Charlotte M Beaver; Scott T Younger; Victor Zhivich; Hanna Najgebauer; Felicity Allen; Emanuel Gonçalves; Rebecca Shepherd; John G Doench; Kosuke Yusa; Francisca Vazquez; Leopold Parts; Jesse S Boehm; Todd R Golub; William C Hahn; David E Root; Mathew J Garnett; Aviad Tsherniak; Francesco Iorio

  Nature communications, 20 Dec. 2019, Peer-reviewed

  
• Genome-wide CRISPR-Cas9 screening in mammalian cells.

  Jason S L Yu; Kosuke Yusa

  Methods (San Diego, Calif.), 15 Jul. 2019, Peer-reviewed

  
• CRISPR-Knockout Screen Identifies Dmap1 as a Regulator of Chemically Induced Reprogramming and Differentiation of Cardiac Progenitors.

  Jason S L Yu; Giorgia Palano; Cindy Lim; Aldo Moggio; Lauren Drowley; Alleyn T Plowright; Mohammad Bohlooly-Y; Barry S Rosen; Emil M Hansson; Qing-Dong Wang; Kosuke Yusa

  Stem cells (Dayton, Ohio), Jul. 2019, Peer-reviewed

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• Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening.

  Gabriele Picco; Elisabeth D Chen; Luz Garcia Alonso; Fiona M Behan; Emanuel Gonçalves; Graham Bignell; Angela Matchan; Beiyuan Fu; Ruby Banerjee; Elizabeth Anderson; Adam Butler; Cyril H Benes; Ultan McDermott; David Dow; Francesco Iorio; Euan Stronach; Fengtang Yang; Kosuke Yusa; Julio Saez-Rodriguez; Mathew J Garnett

  Nature communications, 16 May 2019, Peer-reviewed

  
• Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

  Fiona M Behan; Francesco Iorio; Gabriele Picco; Emanuel Gonçalves; Charlotte M Beaver; Giorgia Migliardi; Rita Santos; Yanhua Rao; Francesco Sassi; Marika Pinnelli; Rizwan Ansari; Sarah Harper; David Adam Jackson; Rebecca McRae; Rachel Pooley; Piers Wilkinson; Dieudonne van der Meer; David Dow; Carolyn Buser-Doepner; Andrea Bertotti; Livio Trusolino; Euan A Stronach; Julio Saez-Rodriguez; Kosuke Yusa; Mathew J Garnett

  Nature, Apr. 2019, Peer-reviewed

  
• JACKS: joint analysis of CRISPR/Cas9 knockout screens.

  Felicity Allen; Fiona Behan; Anton Khodak; Francesco Iorio; Kosuke Yusa; Mathew Garnett; Leopold Parts

  Genome research, Mar. 2019, Peer-reviewed

  
• Genome-wide CRISPR Screens in T Helper Cells Reveal Pervasive Crosstalk between Activation and Differentiation.

  Johan Henriksson; Xi Chen; Tomás Gomes; Ubaid Ullah; Kerstin B Meyer; Ricardo Miragaia; Graham Duddy; Jhuma Pramanik; Kosuke Yusa; Riitta Lahesmaa; Sarah A Teichmann

  Cell, 07 Feb. 2019, Peer-reviewed

  
• Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects.

  Emanuel Gonçalves; Fiona M Behan; Sandra Louzada; Damien Arnol; Euan A Stronach; Fengtang Yang; Kosuke Yusa; Oliver Stegle; Francesco Iorio; Mathew J Garnett

  Genome biology, 05 Feb. 2019, Peer-reviewed

  
• ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.

  Gabriel Balmus; Domenic Pilger; Julia Coates; Mukerrem Demir; Matylda Sczaniecka-Clift; Ana C Barros; Michael Woods; Beiyuan Fu; Fengtang Yang; Elisabeth Chen; Matthias Ostermaier; Tatjana Stankovic; Hannes Ponstingl; Mareike Herzog; Kosuke Yusa; Francisco Munoz Martinez; Stephen T Durant; Yaron Galanty; Petra Beli; David J Adams; Allan Bradley; Emmanouil Metzakopian; Josep V Forment; Stephen P Jackson

  Nature communications, 08 Jan. 2019, Peer-reviewed

  
• SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4.

  Konstantinos Tzelepis; Etienne De Braekeleer; Demetrios Aspris; Isaia Barbieri; M S Vijayabaskar; Wen-Hsin Liu; Malgorzata Gozdecka; Emmanouil Metzakopian; Hamish D Toop; Monika Dudek; Samuel C Robson; Francisco Hermida-Prado; Yu Hsuen Yang; Roya Babaei-Jadidi; Dimitrios A Garyfallos; Hannes Ponstingl; Joao M L Dias; Paolo Gallipoli; Michael Seiler; Silvia Buonamici; Binje Vick; Andrew J Bannister; Roland Rad; Rab K Prinjha; John C Marioni; Brian Huntly; Jennifer Batson; Jonathan C Morris; Cristina Pina; Allan Bradley; Irmela Jeremias; David O Bates; Kosuke Yusa; Tony Kouzarides; George S Vassiliou

  Nature communications, 19 Dec. 2018, Peer-reviewed

  
• Pooled extracellular receptor-ligand interaction screening using CRISPR activation.

  Zheng-Shan Chong; Shuhei Ohnishi; Kosuke Yusa; Gavin J Wright

  Genome biology, 26 Nov. 2018, Peer-reviewed

  
• Genome-scale identification of cellular pathways required for cell surface recognition.

  Sumana Sharma; S Josefin Bartholdson; Amalie C M Couch; Kosuke Yusa; Gavin J Wright

  Genome research, Sep. 2018, Peer-reviewed

  
• Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting.

  Francesco Iorio; Fiona M Behan; Emanuel Gonçalves; Shriram G Bhosle; Elisabeth Chen; Rebecca Shepherd; Charlotte Beaver; Rizwan Ansari; Rachel Pooley; Piers Wilkinson; Sarah Harper; Adam P Butler; Euan A Stronach; Julio Saez-Rodriguez; Kosuke Yusa; Mathew J Garnett

  BMC genomics, 13 Aug. 2018, Peer-reviewed

  
• Genome-wide CRISPR-KO Screen Uncovers mTORC1-Mediated Gsk3 Regulation in Naive Pluripotency Maintenance and Dissolution.

  Meng Li; Jason S L Yu; Katarzyna Tilgner; Swee Hoe Ong; Hiroko Koike-Yusa; Kosuke Yusa

  Cell reports, 10 Jul. 2018, Peer-reviewed

  
• A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells.

  Kei Fukuda; Akihiko Okuda; Kosuke Yusa; Yoichi Shinkai

  Genome research, Jun. 2018, Peer-reviewed

  
• Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance.

  Stephen J Pettitt; Dragomir B Krastev; Inger Brandsma; Amy Dréan; Feifei Song; Radoslav Aleksandrov; Maria I Harrell; Malini Menon; Rachel Brough; James Campbell; Jessica Frankum; Michael Ranes; Helen N Pemberton; Rumana Rafiq; Kerry Fenwick; Amanda Swain; Sebastian Guettler; Jung-Min Lee; Elizabeth M Swisher; Stoyno Stoynov; Kosuke Yusa; Alan Ashworth; Christopher J Lord

  Nature communications, 10 May 2018, Peer-reviewed

  
• Constitutively Active SMAD2/3 Are Broad-Scope Potentiators of Transcription-Factor-Mediated Cellular Reprogramming.

  Tyson Ruetz; Ulrich Pfisterer; Bruno Di Stefano; James Ashmore; Meryam Beniazza; Tian V Tian; Daniel F Kaemena; Luca Tosti; Wenfang Tan; Jonathan R Manning; Eleni Chantzoura; Daniella Rylander Ottosson; Samuel Collombet; Anna Johnsson; Erez Cohen; Kosuke Yusa; Sten Linnarsson; Thomas Graf; Malin Parmar; Keisuke Kaji

  Cell stem cell, 07 Dec. 2017, Peer-reviewed

  
• Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia.

  Oliver M Dovey; Jonathan L Cooper; Annalisa Mupo; Carolyn S Grove; Claire Lynn; Nathalie Conte; Robert M Andrews; Suruchi Pacharne; Konstantinos Tzelepis; M S Vijayabaskar; Paul Green; Roland Rad; Mark Arends; Penny Wright; Kosuke Yusa; Allan Bradley; Ignacio Varela; George S Vassiliou

  Blood, 26 Oct. 2017, Peer-reviewed

  
• Optimised metrics for CRISPR-KO screens with second-generation gRNA libraries.

  Swee Hoe Ong; Yilong Li; Hiroko Koike-Yusa; Kosuke Yusa

  Scientific reports, 07 Aug. 2017, Peer-reviewed

  
• Applications of CRISPR genome editing technology in drug target identification and validation.

  Quinn Lu; George P Livi; Sundip Modha; Kosuke Yusa; Ricardo Macarrón; David J Dow

  Expert opinion on drug discovery, Jun. 2017, Peer-reviewed

  
• A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.

  Konstantinos Tzelepis; Hiroko Koike-Yusa; Etienne De Braekeleer; Yilong Li; Emmanouil Metzakopian; Oliver M Dovey; Annalisa Mupo; Vera Grinkevich; Meng Li; Milena Mazan; Malgorzata Gozdecka; Shuhei Ohnishi; Jonathan Cooper; Miten Patel; Thomas McKerrell; Bin Chen; Ana Filipa Domingues; Paolo Gallipoli; Sarah Teichmann; Hannes Ponstingl; Ultan McDermott; Julio Saez-Rodriguez; Brian J P Huntly; Francesco Iorio; Cristina Pina; George S Vassiliou; Kosuke Yusa

  Cell reports, 18 Oct. 2016, Peer-reviewed

  
• Mutational History of a Human Cell Lineage from Somatic to Induced Pluripotent Stem Cells.

  Foad J Rouhani; Serena Nik-Zainal; Arthur Wuster; Yilong Li; Nathalie Conte; Hiroko Koike-Yusa; Natsuhiko Kumasaka; Ludovic Vallier; Kosuke Yusa; Allan Bradley

  PLoS genetics, Apr. 2016, Peer-reviewed

  
• piggyBac Transposon.

  Kosuke Yusa

  Microbiology spectrum, Apr. 2015, Peer-reviewed

  
• Off-target assessment of CRISPR-Cas9 guiding RNAs in human iPS and mouse ES cells.

  E-Pien Tan; Yilong Li; Martin Del Castillo Velasco-Herrera; Kosuke Yusa; Allan Bradley

  Genesis (New York, N.Y. : 2000), Feb. 2015, Peer-reviewed

  
• piggyBac transposon-based insertional mutagenesis in mouse haploid embryonic stem cells.

  Stephen J Pettitt; E-Pien Tan; Kosuke Yusa

  Methods in molecular biology (Clifton, N.J.), 2015, Peer-reviewed

  
• Simulation and estimation of gene number in a biological pathway using almost complete saturation mutagenesis screening of haploid mouse cells.

  Masahiro Tokunaga; Chikara Kokubu; Yusuke Maeda; Jun Sese; Kyoji Horie; Nakaba Sugimoto; Taroh Kinoshita; Kosuke Yusa; Junji Takeda

  BMC genomics, 24 Nov. 2014, Peer-reviewed

  
• Removal of reprogramming transgenes improves the tissue reconstitution potential of keratinocytes generated from human induced pluripotent stem cells.

  Ken Igawa; Chikara Kokubu; Kosuke Yusa; Kyoji Horie; Yasuhide Yoshimura; Kaori Yamauchi; Hirofumi Suemori; Hiroo Yokozeki; Masashi Toyoda; Nobutaka Kiyokawa; Hajime Okita; Yoshitaka Miyagawa; Hidenori Akutsu; Akihiro Umezawa; Ichiro Katayama; Junji Takeda

  Stem cells translational medicine, Sep. 2014, Peer-reviewed

  
• Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library.

  Hiroko Koike-Yusa; Yilong Li; E-Pien Tan; Martin Del Castillo Velasco-Herrera; Kosuke Yusa

  Nature Biotechnology, Mar. 2014, Peer-reviewed

  
• Seamless genome editing in human pluripotent stem cells using custom endonuclease-based gene targeting and the piggyBac transposon.

  Kosuke Yusa

  Nature protocols, Oct. 2013, Peer-reviewed

  
• Enhancement of microhomology-mediated genomic rearrangements by transient loss of mouse Bloom syndrome helicase.

  Ayako Yamanishi; Kosuke Yusa; Kyoji Horie; Masahiro Tokunaga; Kohji Kusano; Chikara Kokubu; Junji Takeda

  Genome research, Sep. 2013, Peer-reviewed

  
• Nuclear Wave1 is required for reprogramming transcription in oocytes and for normal development.

  Kei Miyamoto; Marta Teperek; Kosuke Yusa; George E Allen; Charles R Bradshaw; J B Gurdon

  Science (New York, N.Y.), 30 Aug. 2013, Peer-reviewed

  
• A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.

  Roland Rad; Juan Cadiñanos; Lena Rad; Ignacio Varela; Alexander Strong; Lydia Kriegl; Fernando Constantino-Casas; Stefan Eser; Maren Hieber; Barbara Seidler; Stacey Price; Mario F Fraga; Vincenzo Calvanese; Gary Hoffman; Hannes Ponstingl; Günter Schneider; Kosuke Yusa; Carolyn Grove; Roland M Schmid; Wei Wang; George Vassiliou; Thomas Kirchner; Ultan McDermott; Pentao Liu; Dieter Saur; Allan Bradley

  Cancer cell, 08 Jul. 2013, Peer-reviewed

  
• The piggyBac transposon displays local and distant reintegration preferences and can cause mutations at noncanonical integration sites.

  Meng Amy Li; Stephen J Pettitt; Sabine Eckert; Zemin Ning; Stephen Rice; Juan Cadiñanos; Kosuke Yusa; Nathalie Conte; Allan Bradley

  Molecular and cellular biology, Apr. 2013, Peer-reviewed

  
• Hyperactive piggyBac gene transfer in human cells and in vivo.

  Joseph E Doherty; Leslie E Huye; Kosuke Yusa; Liqin Zhou; Nancy L Craig; Matthew H Wilson

  Human gene therapy, Mar. 2012, Peer-reviewed

  
• The critical role of histone H2A-deubiquitinase Mysm1 in hematopoiesis and lymphocyte differentiation.

  Anastasia Nijnik; Simon Clare; Christine Hale; Claire Raisen; Rebecca E McIntyre; Kosuke Yusa; Aaron R Everitt; Lynda Mottram; Christine Podrini; Mark Lucas; Jeanne Estabel; David Goulding; Niels Adams; Ramiro Ramirez-Solis; Jacqui K White; David J Adams; Robert E W Hancock; Gordon Dougan

  Blood, 09 Feb. 2012, Peer-reviewed

  
• Mobilization of giant piggyBac transposons in the mouse genome.

  Meng Amy Li; Daniel J Turner; Zemin Ning; Kosuke Yusa; Qi Liang; Sabine Eckert; Lena Rad; Tomas W Fitzgerald; Nancy L Craig; Allan Bradley

  Nucleic acids research, Dec. 2011, Peer-reviewed

  
• A homozygous mutant embryonic stem cell bank applicable for phenotype-driven genetic screening.

  Kyoji Horie; Chikara Kokubu; Junko Yoshida; Keiko Akagi; Ayako Isotani; Akiko Oshitani; Kosuke Yusa; Ryuji Ikeda; Yue Huang; Allan Bradley; Junji Takeda

  Nature methods, 23 Oct. 2011, Peer-reviewed

  
• Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells.

  Kosuke Yusa; S Tamir Rashid; Helene Strick-Marchand; Ignacio Varela; Pei-Qi Liu; David E Paschon; Elena Miranda; Adriana Ordóñez; Nicholas R F Hannan; Foad J Rouhani; Sylvie Darche; Graeme Alexander; Stefan J Marciniak; Noemi Fusaki; Mamoru Hasegawa; Michael C Holmes; James P Di Santo; David A Lomas; Allan Bradley; Ludovic Vallier

  Nature, 12 Oct. 2011, Peer-reviewed

  
• Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells.

  Jeannine R LaRocque; Jeremy M Stark; Jin Oh; Ekaterina Bojilova; Kosuke Yusa; Kyoji Horie; Junji Takeda; Maria Jasin

  Proceedings of the National Academy of Sciences of the United States of America, 19 Jul. 2011, Peer-reviewed

  
• A hyperactive piggyBac transposase for mammalian applications.

  Kosuke Yusa; Liqin Zhou; Meng Amy Li; Allan Bradley; Nancy L Craig

  Proceedings of the National Academy of Sciences of the United States of America, 25 Jan. 2011, Peer-reviewed

  
• PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice.

  Roland Rad; Lena Rad; Wei Wang; Juan Cadinanos; George Vassiliou; Stephen Rice; Lia S Campos; Kosuke Yusa; Ruby Banerjee; Meng Amy Li; Jorge de la Rosa; Alexander Strong; Dong Lu; Peter Ellis; Nathalie Conte; Fang Tang Yang; Pentao Liu; Allan Bradley

  Science (New York, N.Y.), 19 Nov. 2010, Peer-reviewed

  
• Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes.

  Prashant Mali; Bin-Kuan Chou; Jonathan Yen; Zhaohui Ye; Jizhong Zou; Sarah Dowey; Robert A Brodsky; Joyce E Ohm; Wayne Yu; Stephen B Baylin; Kosuke Yusa; Allan Bradley; David J Meyers; Chandrani Mukherjee; Philip A Cole; Linzhao Cheng

  Stem cells (Dayton, Ohio), Apr. 2010, Peer-reviewed

  
• Genome-wide forward genetic screens in mouse ES cells.

  Meng Amy Li; Stephen J Pettitt; Kosuke Yusa; Allan Bradley

  Methods in enzymology, 2010, Peer-reviewed

  
• Fezf1 is required for penetration of the basal lamina by olfactory axons to promote olfactory development.

  Yasuhito Watanabe; Kiyoshi Inoue; Ayako Okuyama-Yamamoto; Nobuhiro Nakai; Jin Nakatani; Ken-Ichi Nibu; Naoko Sato; Yasuhiko Iiboshi; Kosuke Yusa; Gen Kondoh; Junji Takeda; Toshio Terashima; Toru Takumi

  The Journal of comparative neurology, 10 Aug. 2009, Peer-reviewed

  
• Generation of transgene-free induced pluripotent mouse stem cells by the piggyBac transposon.

  Kosuke Yusa; Roland Rad; Junji Takeda; Allan Bradley

  Nature methods, May 2009, Peer-reviewed

  
• Sleeping beauty transposase has an affinity for heterochromatin conformation.

  Ryuji Ikeda; Chikara Kokubu; Kosuke Yusa; Vincent W Keng; Kyoji Horie; Junji Takeda

  Molecular and cellular biology, Mar. 2007, Peer-reviewed

  
• Rad54 is dispensable for the ALT pathway.

  Koichi Akiyama; Kosuke Yusa; Hideharu Hashimoto; Anuradha Poonepalli; Manoor Prakash Hande; Naoki Kakazu; Junji Takeda; Makoto Tachibana; Yoichi Shinkai

  Genes to cells : devoted to molecular & cellular mechanisms, Nov. 2006, Peer-reviewed

  
• Sleeping beauty transposon-based phenotypic analysis of mice: lack of Arpc3 results in defective trophoblast outgrowth.

  Kojiro Yae; Vincent W Keng; Masato Koike; Kosuke Yusa; Michiyoshi Kouno; Yoshihiro Uno; Gen Kondoh; Takahiro Gotow; Yasuo Uchiyama; Kyoji Horie; Junji Takeda

  Molecular and cellular biology, Aug. 2006, Peer-reviewed

  
• Bloom's syndrome gene-deficient phenotype in mouse primary cells induced by a modified tetracycline-controlled trans-silencer.

  Tomoko Hayakawa; Kosuke Yusa; Michiyoshi Kouno; Junji Takeda; Kyoji Horie

  Gene, 15 Mar. 2006, Peer-reviewed

  
• New strategy for comprehensive analysis of gene functions in embryonic stem cells

  J. Takeda; K. Horie; K. Yusa

  STEM CELLS IN REPRODUCTION AND IN THE BRAIN, 2006, Peer-reviewed

  
• Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system.

  Vincent W Keng; Kojiro Yae; Tomoko Hayakawa; Sumi Mizuno; Yoshihiro Uno; Kosuke Yusa; Chikara Kokubu; Taroh Kinoshita; Keiko Akagi; Nancy A Jenkins; Neal G Copeland; Kyoji Horie; Junji Takeda

  Nature methods, Oct. 2005, Peer-reviewed

  
• Genome-wide phenotype analysis in ES cells by regulated disruption of Bloom's syndrome gene.

  Kosuke Yusa; Kyoji Horie; Gen Kondoh; Michiyoshi Kouno; Yusuke Maeda; Taroh Kinoshita; Junji Takeda

  Nature, 24 Jun. 2004, Peer-reviewed

  
• Enhancement of Sleeping Beauty transposition by CpG methylation: possible role of heterochromatin formation.

  Kosuke Yusa; Junji Takeda; Kyoji Horie

  Molecular and cellular biology, May 2004, Peer-reviewed

  
• Characterization of Sleeping Beauty transposition and its application to genetic screening in mice.

  Kyoji Horie; Kosuke Yusa; Kojiro Yae; Junko Odajima; Sylvia E J Fischer; Vincent W Keng; Tomoko Hayakawa; Sumi Mizuno; Gen Kondoh; Takashi Ijiri; Yoichi Matsuda; Ronald H A Plasterk; Junji Takeda

  Molecular and cellular biology, Dec. 2003, Peer-reviewed

  

Misc.

• Inferring gene regulatory networks based on expression dynamics induced by gene perturbations

  石川雅人; 杉野成一; 増田芳恵; 樽本雄介; 瀬戸裕介; 谷山暢子; 和穎文; 山内悠平; 小嶋泰弘; 木立尚孝; 遊佐宏介; 永樂元次; 望月敦史

  日本数理生物学会年会(Web), 2024

  
• Genome-wide CRISPR screening for host factors involved in bornavirus cell entry

  松郷宙倫; 松郷宙倫; 遊佐宏介; 牧野晶子; 牧野晶子; 朝長啓造; 朝長啓造; 朝長啓造

  日本ウイルス学会学術集会プログラム・予稿集(Web), 2024

  
• CRISPR-KO screen identifies genes that regulate human iPSC differentiation into definitive endoderm

  平野友章; 杉野成一; 樽本雄介; 遊佐宏介

  日本ゲノム編集学会大会要旨集, 2024

  
• Regulation of cell fate by manipulation of dynamics of gene regulatory network

  樽本雄介; 杉野成一; 山内悠平; 石川雅人; 和穎文; 永樂元次; 望月敦史; 遊佐宏介

  日本ゲノム編集学会大会要旨集, 2024

  
• Analysis of dynamics of gene regulatory network using CRISPR-mediated transcriptional pertubation

  樽本雄介; 杉野成一; 遊佐宏介

  日本ゲノム編集学会大会要旨集, 2023

  
• CRISPR-based functional genomics analysis

  樽本雄介; 遊佐宏介

  実験医学, 2024

  
• Genetic Engineering in Human iPS Cells Using ZFN/TALEN and piggyBac Transposon

  遊佐 宏介

  細胞工学, 2013

  
• ポストゲノムにおける遺伝子改変マウスの新たな展開

  遊佐 宏介; 堀江 恭二; 竹田 潤二

  蛋白質核酸酵素, Mar. 2003

  
• マウスにおけるトランスポゾン研究の進展 (特集 トランスポゾンによる進化,変異導入の生物学的意義)

  堀江 恭二; 遊佐 宏介; 竹田 潤二

  蛋白質核酸酵素, Oct. 2004

  
• Development and improvement of high-throughput CRISPR-Cas9 genetic screening

  樽本雄介; 遊佐宏介

  生体の科学, 2020

  
• TOWARDS PERSONALISED REGENERATIVE MEDICINE: MUTATIONS IN HUMAN INDUCED PLURIPOTENT STEM CELLS

  Foad Rouhani; Serena Nik-Zainal; Ludovic Vallier; Kosuke Yusa; Allan Bradley

  TRANSPLANT INTERNATIONAL, Sep. 2017

  
• Identification of factors involved in provirus silencing by CRISPR-Cas9 system

  Kei Fukuda; Kosuke Yusa; Yoichi Shinkai

  GENES & GENETIC SYSTEMS, Dec. 2016

  
• A Crispr/Cas9 Drop-out Screen Identifies Genome-Wide Genetic Valnerubilities in Acute Myeloid Leukaemia

  Konstantinos Tzelepis; Hiroko Koike-Yusa; Etienne De Braekeleer; Yilong Li; Emmanouil Metzakopian; Oliver M. Dovey; Annalisa Mupo; Vera Grinkevich; Milena M. Mazan; Malgorzata Gozdecka; Jonathan L. Cooper; Miten Patel; Thomas David Hardman McKerrell; Bin Chen; Hannes Ponstingl; Brian J. P. Huntly; Ultan McDermott; Julio Saez-Rodriguez; Francesco Iorio; Kosuke Yusa; George S. Vassiliou

  BLOOD, Dec. 2015

  
• Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library

  Kosuke Yusa

  HUMAN GENE THERAPY, Sep. 2015

  
• TOWARDS CELL BASED THERAPY FOR alpha 1-ANTITRYPSIN DEFICIENCY THROUGH TARGETED BI-ALLELIC GENE CORRECTION IN HUMAN IPS CELLS

  S. Tamir Rashid; Kosuke Yusa; Helene Strick-Marchand; Foad Rouhani; Elena Miranda; Nicholas R. Hannan; Stefan J. Marciniak; Graeme J. Alexander; James Di Santo; Allan Bradley; David A. Lomas; Ludovic Vallier

  HEPATOLOGY, Oct. 2011

  
• A trial of in vitro reconstitution of human skin using transgene-free induced pluripotent stem cells

  Ken Igawa; Jun Harada; Yukinobu Nakagawa; Kyoji Horie; Kosuke Yusa; Hiroo Yokozeki; Junji Takeda; Ichiro Katayama

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, Sep. 2011

  
• [Recent progress in mouse transposon research].

  Kyoji Horie; Kosuke Yusa; Junji Takeda

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Oct. 2004

  
• [New perspectives on genetically engineered mice in post-genomic era].

  Kosuke Yusa; Kyoji Horie; Junji Takeda

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Mar. 2003

  

Presentations

• Development and Applications of CRISPR-KO Screening

  遊佐宏介

  第96会日本生化学会大会, 01 Nov. 2023, Invited

  
• Development and Applications of CRISPR-KO Screening

  遊佐宏介

  第82会日本がん学会学術総会, 23 Sep. 2023, Invited

  
• CRISPR-KOスクリーニングの開発と応用

  遊佐宏介

  関西小型魚類有志勉強会, 28 Aug. 2023, Invited

  
• CRISPR-KOスクリーニングの開発と応用

  遊佐宏介

  中外製薬セミナー, 12 Apr. 2023, Invited

  
• CRISPR-KO スクリーニングの開発と応用

  遊佐宏介

  第45回日本分子生物学会年会, 30 Nov. 2022, Invited

  
• Development of CRISPR-KO Screening and its Applications in Cancer Research

  Kosuke Yusa

  International Academy for Advanced Oncology 2022, 29 Jul. 2022, Invited

  
• Development and Applications of CRISPR-KO Screening

  Kosuke Yusa

  第31会日本がん転移学会学術集会・総会, 07 Jul. 2022, Invited

  
• 大規模CRISPR遺伝子スクリーニングによる 創薬標的の探索と検証

  遊佐宏介

  理化学研究所DMP創薬セミナー, 25 Apr. 2022, Invited

  
• CRISPR-KOスクリーニングの開発と応用

  遊佐宏介

  第21回日本再生医療学会総会, 19 Mar. 2022, Invited

  
• ヒトES/iPS細胞に蓄積される変異

  遊佐宏介

  第一回京都大学ウイルス・再生医科学研究所附属ヒトES細胞研究センターシンポジウム, 09 Mar. 2022, Invited

  
• Development and Applications of CRISPR-KO Screening

  Kosuke Yusa

  The 27th East Asia Joint Symposium, 27 Oct. 2021, Invited

  
• CRISPR-KOスクリーニングの開発と応用

  遊佐宏介

  第80会日本癌学会学術総会, 02 Oct. 2021, Invited

  
• CRISPR-KOスクリーニングの開発と応用

  遊佐宏介

  第73回日本細胞生物学会大会, 30 Jun. 2021, Invited

  
• CRISPR-KOスクリーニングの開発と応用

  遊佐宏介

  日本生化学会北陸支部第39回大会, 05 Jun. 2021, Invited

  
• Genetic Dissection of Pluripotency Maintenance using CRISPR-KO Screenning

  遊佐宏介

  第110回日本病理学会総会, 22 Apr. 2021, Invited

  
• Development and Application of CRISPR-KO Screening

  遊佐宏介

  第43回日本分子生物学会年会, 03 Dec. 2020, Invited

  
• CRISPR-KOスクリーニングの開発と創薬研究への応用

  遊佐宏介

  千里ライフサイエンスセミナー, 04 Nov. 2020, Invited

  
• Development and Application of CRISPR-KO Screening

  遊佐宏介

  第79回日本癌学会学術総会, 01 Oct. 2020, Invited

  
• Development and Application of CRISPR-KO Screening

  遊佐宏介

  熊本大学発生医学研究所, 29 Jul. 2020, Invited

  
• Development and Application of Genome-Wide CRISPR-KO Screening

  遊佐宏介

  大阪大学微生物病研究所BRIDGEセミナー, 07 Feb. 2020, Invited

  
• Development of CRISPR-KO screening and its application in oncology research

  遊佐宏介

  愛知県がんセンター, 18 Dec. 2019, Invited

  
• Prioritization of cancer therapeutic targets using CRISRP-Cas9 screens

  遊佐宏介

  第8回Cancer Stem Cell Symposium, 30 Nov. 2019, Invited

  
• Development and Application of CRISPR-KO Screening

  Frontiers in Genome Engineering 2019, 25 Nov. 2019, Invited

  
• Development and Application of Genome-Wide CRISPR-KO Screening

  遊佐宏介

  和歌山県立医科大学, 14 Nov. 2019, Invited

  
• Development and Application of CRISPR-KO Screening

  遊佐宏介

  第１４回生命医科学研究所ネットワーク国際シンポジウム, 02 Oct. 2019, Invited

  
• Development and application of genome-wide CRISPR-KO screening

  Kosuke Yusa

  SULSA Disruptive technologies, 26 Sep. 2019, Invited

  
• Development and application of genome-wide CRISPR-KO screening

  遊佐 宏介

  日本遺伝学会第91回大会, 13 Sep. 2019, Invited

  
• Development and application of genome-wide CRISPR-KO screening

  Kosuke Yusa

  東京大学先端科学技術研究センター, 10 Sep. 2019, Invited

  
• Development and application of genome-wide CRISPR-KO screening

  Kosuke Yusa

  高遠 分子細胞生物学シンポジウム, 23 Aug. 2019

  
• ゲノム編集技術を使ったがん研究

  遊佐 宏介

  ウイルス・再生医科学研究所公開講演会, 20 Jul. 2019, Invited

  
• Oncology drug candidates identified from a large-scale genome-wide CRISPR screen

  Kosuke Yusa

  理化学研究所 和光, 21 Jan. 2019

  

Books and Other Publications

• がんゲノムペディア : 77のキーワードで理解するゲノム医療とゲノム研究

  Contributor, CRISPRスクリーニング

  羊土社, Feb. 2024

  Find Kyoto University's collection of books :

  
• CRISPR-KOスクリーニングの開発と応用

  遊佐宏介

  最新のゲノム編集技術と用途展開, 2020

  
• 医療・創薬に向けたCRISPRスクリーニング

  遊佐宏介

  遺伝子医学, 2020

  
• CRISPR/Cas9に遺伝学スクリーニングシステムの開発

  樽本雄介; 遊佐宏介

  生体の科学, 2020

  
• CRISPR-Cas9システムの遺伝学スクリーニングへの応用

  遊佐宏介

  医学のあゆみ, 2020

  
• CRIPSRスクリーニングによる幹細胞制御因子の網羅的探索

  遊佐宏介

  医学のあゆみ, 2020

  
• CRISPR-KOスクリーニングによるがん治療候補の優先化

  遊佐宏介

  医学のあゆみ, 2020

  
• CRISPRライブラリーを用いた遺伝子スクリーニング法

  遊佐宏介

  実験医学別冊 ゲノム編集実験スタンダード, 2019

  

External funds: others

• 脂肪分化を制御する代謝エピゲノム因子のCRISPRスクリーニング

  群馬大学生体調節研究所「内分秘・代謝学共同研究拠点」

  From 01 Apr. 2021, To 31 Mar. 2022

  遊佐宏介
• 完全無細 AAV ベクター合成技術 発

  東京大学医科学研究所国内共同研究

  From 01 Apr. 2021, To 31 Mar. 2022

  遊佐宏介

Education

Teaching subject(s)

• From 01 Apr. 2023, To 31 Mar. 2024

  Molecular Genetics II

  3726, Spring, Faculty of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Molecular Genetics II

  3726, Spring, Faculty of Science, 2
• From Apr. 2019, To Mar. 2020

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2020, To Mar. 2021

  ILAS Seminar :Seminar on Developmental Biology and Regenerative Medicine

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2021, To Mar. 2022

  Molecular Genetics II

  Spring, 理学部

Participation in PhD Defense

• Target-dependent RNA polymerase as universal platform for gene expression control in response to intracellular molecules

  KOMATSU SHODAI, Graduate School of Medicine, Chief Examiner

  25 Mar. 2024
• Uniform transgene activation in Tet-On systems depends on sustained rtTA expression

  OTOMO JUN, Graduate School of Medicine, Chief Examiner

  25 Mar. 2024
• Brg1 controls stemness and metastasis of pancreatic cancer through regulating hypoxia pathway

  ARAKI OSAMU, Graduate School of Medicine, Chief Examiner

  25 Mar. 2024
• Dual CRISPR-Cas3 system for inducing multi-exon skipping in DMD patient-derived iPSCs

  KITA YUTO, Graduate School of Medicine, Chief Examiner

  23 Jan. 2024
• Integrative analysis of cancer dependency data and comprehensive phosphoproteomics data revealed the EPHA2-PARD3 axis as a cancer vulnerability in KRAS-mutant colorectal cancer

  GUNJI DAIGO, Graduate School of Medicine, Chief Examiner

  25 Sep. 2023
• Collagen X is dispensable for hypertrophic differentiation and endochondral ossification of human iPSC-derived chondrocytes

  KAMAKURA TAKESHI, Graduate School of Medicine, Sub-chief Examiner

  24 Jul. 2023
• Pluripotent stem cell model of Shwachman-Diamond syndrome reveals apoptotic predisposition of hemoangiogenic progenitors

  HAMABATA TAKAYUKI, Graduate School of Medicine, Sub-chief Examiner

  23 May 2023
• Differentiation of Hypertrophic Chondrocytes from Human iPSCs for the In Vitro Modeling of Chondrodysplasias

  PRETEMER YANN, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Enhancement of Regnase-1 expression with stem loop-targeting antisense oligonucleotides alleviates inflammatory diseases

  Tse Ka Man Carman, Graduate School of Medicine, Sub-chief Examiner

  26 Sep. 2022
• Essential role of Notch/Hes1 signaling in postnatal pancreatic　exocrine development

  KURIYAMA KATSUTOSHI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Tracing the evolutionary history of blood cells to the unicellular ancestor of animals

  NAGAHATA YOSUKE, Graduate School of Medicine, Sub-chief Examiner

  23 Jan. 2023
• Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1

  MAKINO YUKI, Graduate School of Medicine, Chief Examiner

  24 Nov. 2022
• Systemic Supplementation of Collagen VI by Neonatal Transplantation of iPSC-Derived MSCs Improves　Histological Phenotype and Function of Col6-Deficient Model Mice

  HARADA AYA, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• CDH18 is a fetal epicardial biomarker regulating differentiation towards vascular smooth muscle cells

  Julia Junghof, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• DMRT1-mediated reprogramming drives development of cancer resembling human germ cell tumors with features of totipotency

  TAGUCHI JUMPEI, Graduate School of Medicine, Chief Examiner

  24 Jan. 2022
• Extracellular vesicles synchronize cellular phenotypes of differentiating cells

  MINAKAWA TOMOHIRO, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022

Student achievements: Presentations

• CRISPRスクリーニングによるヒトiPS細胞の胚性内胚葉分化制御遺伝子の同定

  平野友章、杉野成一、樽本雄介、遊佐宏介

  日本ゲノム編集学会第9回大会, 19 Jun. 2024, Japanese, Poster presentation

Administration

Faculty management (title, position)

• From 01 Oct. 2023

  将来構想委員会　委員
• From 20 Jul. 2023

  学術委員会　委員長
• From 01 Apr. 2023

  男女共同参画推進委員会
• From 01 May 2021

  再生実験動物施設飼育室施設運営委員会 委員
• From 01 Apr. 2019

  人権委員会　委員
• From Apr. 2020

  医の倫理委員会　委員長
• From 01 Oct. 2018, To 30 Jun. 2021

  再生医科学動物実験専門委員会　委員
• From 01 Oct. 2018, To 31 Mar. 2020

  化学物質管理委員会
• From 01 Oct. 2019, To 30 Sep. 2021

  医学研究科運営委員会
• From 01 Apr. 2023, To 31 Mar. 2025

  医学図書館運営委員会
• From Aug. 2019, To Jan. 2020

  医学研究科論文調査委員会　委員
• From Feb. 2020, To Jul. 2020

  学研究科論文調査委員会　委員長
• From Apr. 2019, To Mar. 2022

  医学研究科大学院入試委員会　委員