Basic Information

Academic Degree

• 修士（農学）(東京農工大学)
• 修士（生命科学）(東京大学)
• 博士（医学）(東京医科歯科大学)

Research History

• Kyoto University

ID,URL

• J-Global ID

  201401084685082680

researchmap URL

• https://researchmap.jp/toyomoto

Research

Research Topics, Overview of the research

• Research Topics

  1. Next-generation analgesics with no adverse effects of opioids
  2. Next-generation anticancer drugs with protecting healthy tissues

• Overview of the research

  We are engaged in research in order to connect basic medical science research to practical use in clinical. We mainly try to identify target molecules about novel compounds picked up from phenotype screening. I will clarify the mechanism of action and advance the accumulation of basic knowledge of pharmacology in preclinical.
  The above research subject is an example of incorporating a compound into biological experiments and leading to unexpected discoveries. In order to contribute to the increase in the frequency of fortunate discovery, we aim to construct a research base for understanding individual organisms as a system in molecular biology.

Research Areas

• Life sciences, Pharmaceuticals - chemistry and drug development, ケミカルバイオロジー
• Life sciences, Applied molecular and cellular biology

Papers

• The novel compound PICCS improves cell viability during cold storage and reduces pulmonary ischemia-reperfusion injury in a rat model.

  Yuhei Yokoyama; Masayasu Toyomoto; Nobuo Tanaka; Satona Tanaka; Shigeto Nishikawa; Hidenao Kayawake; Yuki Morimura; Hiromi Oda; Momono Yamauchi; Makoto Yamamoto; Toyofumi F Chen-Yoshikawa; Masatoshi Hagiwara; Hiroshi Date

  Scientific reports, 30 Apr. 2025

  
• Platelets accelerate lipid peroxidation and induce pathogenic neutrophil extracellular trap release.

  Madoka Ono; Masayasu Toyomoto; Momono Yamauchi; Masatoshi Hagiwara

  Cell chemical biology, 19 Dec. 2024

  
• Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids

  Takahiro Suezawa; Shuhei Kanagaki; Keita Moriguchi; Atsushi Masui; Kazuhisa Nakao; Masayasu Toyomoto; Koji Tamai; Ryuta Mikawa; Toyohiro Hirai; Koji Murakami; Masatoshi Hagiwara; Shimpei Gotoh

  Stem Cell Reports, Nov. 2021

  
• Endogenous agonist-bound S1PR3 structure reveals determinants of G protein-subtype bias.

  Shintaro Maeda; Yuki Shiimura; Hidetsugu Asada; Kunio Hirata; Fangjia Luo; Eriko Nango; Nobuo Tanaka; Masayasu Toyomoto; Asuka Inoue; Junken Aoki; So Iwata; Masatoshi Hagiwara

  Science advances, Jun. 2021

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• Hydroxypropyl Cyclodextrin Improves Amiodarone-induced Aberrant Lipid Homeostasis of Alveolar Cells.

  Shuhei Kanagaki; Takahiro Suezawa; Keita Moriguchi; Kazuhisa Nakao; Masayasu Toyomoto; Yuki Yamamoto; Koji Murakami; Masatoshi Hagiwara; Shimpei Gotoh

  American journal of respiratory cell and molecular biology, Apr. 2021

  
• S1PR3-G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation.

  Masayasu Toyomoto; Asuka Inoue; Kei Iida; Masatsugu Denawa; Isao Kii; Francois Marie Ngako Kadji; Takayuki Kishi; Dohyun Im; Tatsuro Shimamura; Hiroshi Onogi; Suguru Yoshida; So Iwata; Junken Aoki; Takamitsu Hosoya; Masatoshi Hagiwara

  Cell chemical biology, 02 Feb. 2021

  
• Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation.

  Hiroaki Fuji; Saori Ohmae; Naruto Noma; Masatoshi Takeiri; Hideto Yasutomi; Kazuya Izumi; Moe Ito; Masayasu Toyomoto; Soichiro Iwaki; Kenji Takemoto; Satoru Seo; Kojiro Taura; Shigeaki Hida; Mineyoshi Aoyama; Yasushi Ishihama; Masatoshi Hagiwara; Norihiko Takeda; Etsuro Hatano; Keiko Iwaisako; Shinji Uemoto; Masataka Asagiri

  Biochemical and biophysical research communications, 05 Sep. 2018, Peer-reviewed

  
• Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy

  Yukiya Sako; Kensuke Ninomiya; Yukiko Okuno; Masayasu Toyomoto; Atsushi Nishida; Yuka Koike; Kenji Ohe; Isao Kii; Suguru Yoshida; Naohiro Hashimoto; Takamitsu Hosoya; Masafumi Matsuo; Masatoshi Hagiwara

  SCIENTIFIC REPORTS, May 2017, Peer-reviewed

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• Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K

  Saori Ohmae; Naruto Noma; Masayasu Toyomoto; Masahiro Shinohara; Masatoshi Takeiri; Hiroaki Fuji; Kenji Takemoto; Keiko Iwaisako; Tomoko Fujita; Norihiko Takeda; Makoto Kawatani; Mineyoshi Aoyama; Masatoshi Hagiwara; Yasushi Ishihama; Masataka Asagiri

  SCIENTIFIC REPORTS, Mar. 2017, Peer-reviewed

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• Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors

  Takashi Kurihara; Eri Sakurai; Masayasu Toyomoto; Isao Kii; Daisuke Kawamoto; Toshihide Asada; Tsutomu Tanabe; Megumu Yoshimura; Masatoshi Hagiwara; Atsuro Miyata

  MOLECULAR PAIN, Mar. 2014, Peer-reviewed

  
• Anti-arthritic effect of E3 ubiquitin ligase, c-MIR, expression in the joints

  Masayasu Toyomoto; Satoshi Ishido; Nobuyuki Miyasaka; Hachiro Sugimoto; Hitoshi Kohsaka

  INTERNATIONAL IMMUNOLOGY, Mar. 2011, Peer-reviewed

  
• Intervention of an Inflammation Amplifier, Triggering Receptor Expressed on Myeloid Cells 1, for Treatment of Autoimmune Arthritis

  Yousuke Murakami; Tohru Akahoshi; Naoko Aoki; Masayasu Toyomoto; Nobuyuki Miyasaka; Hitoshi Kohsaka

  ARTHRITIS AND RHEUMATISM, Jun. 2009, Peer-reviewed

  

Misc.

• タウ蛋白質分解誘導による認知症治療を目指した新規化合物の発見

  豊本雅靖; 笹ヶ迫智紀; 喜井勲; 小池悠華; 林佳子; 石田憲太郎; 隅田有人; 吉田優; 細谷孝充; 萩原正敏

  日本生化学会大会(Web), 2016

  
• Duchenne型筋ジストロフィーに対して変異ジストロフィンエキソンのスキッピング誘導活性を有する経口投与可能な新規CLK1阻害剤の開発

  佐古 有季哉; 二宮 賢介; 奥野 友紀子; 豊本 雅靖; 西田 篤史; 小池 悠華; 大江 賢治; 喜井 勲; 吉田 優; 橋本 有弘; 細谷 孝充; 松尾 雅文; 萩原 正敏

  生命科学系学会合同年次大会, Dec. 2017

  
• 炎症性疼痛モデルマウスに対する新規カゼインキナーゼ阻害薬の抗侵害効果

  川元 大輔; 喜井 勲; 豊本 雅靖; 朝田 俊秀; 吉村 惠; 萩原 正敏; 宮田 篤郎; 栗原 崇

  日本薬理学雑誌, Mar. 2013

  
• がん細胞の代謝がもたらす組織微小環境を標的にしたがん治療

  豊本 雅靖; 井上 飛鳥; 飯田 慶; 出縄 政嗣; 喜井 勲; 林 佳子; 岸 貴之; 小野木 博; 吉田 優; 細谷 孝充; 青木 淳賢; 萩原 正敏

  生命科学系学会合同年次大会, Dec. 2017

  
• 非オピオイド鎮痛薬の創製

  豊本雅靖; 豊本雅靖; 栗原崇; 中川貴之; 井上飛鳥; 木村亮; 喜井勲; 喜井勲; 澤田照夫; 澤田照夫; 荻原孝史; 荻原孝史; 永安一樹; 岸貴之; 小野木博; 小野木博; 田口純平; 吉田優; 青木淳賢; 青木淳賢; 細谷孝充; 萩原正敏

  鎮痛薬・オピオイドペプチドシンポジウムプログラム・抄録集, 2021

  
• Hypoxia overcomes contact-dependent proliferative inhibition of rheumatoid synovial fibroblasts by downregulating N-cadherin and subsequent P27(Kip1) expression.

  Yoshinori Nonomura; Masayasu Toyomoto; Tosiniro Nanki; Nobuyuki Miyasaka; Hitoshi Kohsaka

  ARTHRITIS AND RHEUMATISM, Sep. 2006

  

External funds: Kakenhi

• 肺線維化機構の解明と治療標的分子の同定

  Grant-in-Aid for Scientific Research (C)

  Basic Section 53030:Respiratory medicine-related

  Kyoto University

  豊本 雅靖

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  呼吸器疾患;肺線維症;創薬科学;ケミカルバイオロジー;線維化;フェロトーシス;線維化機構;上皮細胞障害

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K08282/