Basic Information

Faculty

• 医学部

Professional Memberships

• 日本エピジェネティクス研究会
• 日本生化学会
• 日本分子生物学会
• 日本実験動物学会
• Japanese Society of Epigenetics
• The Japanese Biochemical Society
• The Molecular Biology Society of Japan
• Japanese Association for Laboratory Animal Science
• 関西実験動物研究会

Academic Degree

• 理学修士(京都大学)
• 理学博士(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院理学研究科修士課程化学専攻, 修了
• 京都大学, 大学院理学研究科博士課程化学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 京都大学, 理学部, 卒業

Research History

• From Dec. 2014, To Present

  Kyoto University, 医学研究科, 教授
• From Apr. 2003, To Nov. 2014

  Kanazawa University, 学祭科学実験センター, 教授
• From Apr. 2008, To Jun. 2014

  Kanazawa University, 学祭科学実験センター, センター長
• From Jan. 2000, To Mar. 2003

  Kanazawa University, 医学部, 教授
• From May 1999, To Dec. 1999

  The University of Tokyo, The Institute of Medical Science, 講師
• From Apr. 1993, To Apr. 1999

  The University of Tokyo, The Institute of Medical Science, 助手
• From Apr. 1991, To Mar. 1993

  マックスプランク生物物理化学研究所, 博士研究員
• From Apr. 1988, To Mar. 1991

  Osaka Bioscience Institute, 特別研究員

ID,URL

• J-Global ID

  200901082865308137

• External link

  http://www.anim.med.kyoto-u.ac.jp/research/index.html

Website(s) (URL(s))

• http://www.anim.med.kyoto-u.ac.jp/research/index.html

researchmap URL

• https://researchmap.jp/ma0413

Research

Research Topics, Overview of the research

• Research Topics

  Functional analysis of carbohydrates and epigenetics in the central nervous system, development and diseases / Rat bioresource

• Overview of the research

  Functional analysis of carbohydrates and epigenetics in the central nervous system (CNS), development and diseases are carried out using gene-manipulated animals. In particular, we generate gene-manipulated mice in glycosyltransferases and histone modification enzymes, and study about their functions in the CNS and development, elucidating the glycol-code and histone-code. We also contribute to expansion of rat research by management of National BioResource Project-Rat (NBRP-Rat), and develop rat reproductive technologies.

Research Interests

• エピジェネティクス
• 糖鎖生物学
• 発生工学
• Epigenetics
• Glycobiology
• Manipulating the Mouse Embryo

Research Areas

• Life sciences, Developmental biology
• Life sciences, Functional biochemistry
• Life sciences, Laboratory animal science

Papers

• Erratum: Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome (Proceedings of the National Academy of Sciences of the United States of America (2009) 13:2 (468-473))

  Chi-Bun Chan; Michiyo Abe; Noriyoshi Hashimoto; Chunhai Hao; Ifor R. Williams; Xia Liu; Shinji Nakao; Akitsugu Yamamoto; Chengyun Zheng; Jan-Inge Henter; Marie Meeths; Magnus Nordenskjold; Shi-Yong Li; Ikuko Hara-Nishimura; Masahide Asano; Keqiang Ye

  Proceedings of the National Academy of Sciences of the United States of America, 07 Apr. 2009

  
• Generation and analysis of voltage-gated calcium channel β₄ subunit conditional knock-out mice

  Katsumi Hayashida; Akito Nakao; Toru Yoshihara; Masahide Asano; Yasuo Mori

  Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2022

  
• Concanavalin A肝障害モデルを用いたサイトカインLECT2の機能解析

  山越 智; 斎藤 武; 奥村 彰規; 渡部 久実; 浅野 雅秀; 安保 徹; 岩倉 洋一郎; 鈴木 和男

  日本免疫学会総会・学術集会記録, Nov. 2003

  
• 関節炎モデルを用いたLECT2の役割解析

  奥村 彰規; 斉藤 武; 大谷 功; 大川原 明子; 浅野 雅秀; 岩倉 洋一郎; 鈴木 和男; 山越 智

  日本免疫学会総会・学術集会記録, Nov. 2003

  
• 肝障害モデルを用いたLECT2の機能解析

  斉藤 武; 奥村 彰規; 渡部 久実; 浅野 雅秀; 大川原 明子; 安保 徹; 岩倉 洋一郎; 鈴木 和男; 山越 智

  日本免疫学会総会・学術集会記録, Oct. 2002

  
• 肝臓で高発現する遺伝子LECT2を破壊したマウスではCon A誘発性肝障害が重症化する

  斉藤 武; 山越 智; 浅野 雅秀; 橋本 ゆき; 波多野 好美; 糸数 義彦; 瀬川 美秀; 岩倉 洋一郎; 鈴木 和男

  日本免疫学会総会・学術集会記録, Nov. 2000

  
• Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth of immunogenic tumors in mice.

  Heng Wei; Chie Naruse; Daisuke Takakura; Kazushi Sugihara; Xuchi Pan; Aki Ikeda; Nana Kawasaki; Masahide Asano

  Frontiers in immunology, 2023

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• Long-lasting housing environment manipulation and acute loss of environmental enrichment impact BALB/c mice behaviour in multiple functional domains.

  Momoe Sukegawa; Toru Yoshihara; Shengqun Hou; Masahide Asano; Anthony J Hannan; Dan Ohtan Wang

  The European journal of neuroscience, Mar. 2022

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• A Simple and Efficient Method for Generating KO Rats Using In Vitro Fertilized Oocytes

  Kohtaro Morita; Arata Honda; Masahide Asano

  Methods in Molecular Biology, 12 Feb. 2023

  
• ガラクトース転移酵素欠損マウスは高免疫原性腫瘍の増殖を抑制する(Galactosyltransferase-deficiency suppresses the growth of immunogenic tumors in mice)

  魏 恒; 成瀬 智恵; 川崎 ナナ; 浅野 雅秀

  日本癌学会総会記事, Sep. 2022

  
• Reg蛋白質受容体欠損マウスの作製とそのβ細胞複製能の低下

  那谷耕司; 高橋巌; 杉原一司; 浅野雅秀; 池田崇之; 野口直哉; 山内晶世; 吉川雄朗; ShervaniNausheen J; 海野倫明; 高沢伸; 岡本宏

  糖尿病, Apr. 2007, Peer-reviewed

  
• 血液脳関門におけるカルニチン/有機カチオントランスポーターOCTN2の機能発現

  大成 亜希; 木戸 康人; 加々美 徹; 崔 吉道; 二階堂 浩子; 橋本 憲佳; 浅野 雅秀; 玉井 郁巳; 辻 彰

  薬物動態, Sep. 2000

  
• ヘパラン硫酸はマウス膵ランゲルハンス島の形態形成やβ細胞増殖、インスリン分泌機能に重要な役割を果たしている

  高橋 巌; 野口 直哉; 那谷 耕司; 山田 修平; 金岩 知之; 水本 秀二; 池田 崇之; 杉原 一司; 浅野 雅秀; 吉川 雄朗; Shervani Nausheen J.; 宇留野 晃; 海野 倫明; 菅原 一幸; 高澤 伸; 岡本 宏; 菅原 明

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Nov. 2008

  
• 膵β細胞特異的糖転移酵素EXTL3欠損マウスはβ細胞増殖能低下と耐糖能異常を生じる

  高橋 巌; 那谷 耕司; 野口 直哉; 池田 崇之; 吉川 雄朗; 山内 晶世; Shervani Nausheen J.; 宇留野 晃; 杉原 一司; 浅野 雅秀; 海野 倫明; 高澤 伸; 岡本 宏; 菅原 明

  糖尿病, Apr. 2008

  
• 糖転移酵素EXTL3の膵β細胞特異的欠損マウスにおけるβ細胞増殖能の低下と耐糖能異常

  高橋 巌; 那谷 耕司; 野口 直哉; 池田 崇之; 吉川 雄朗; 山内 晶世; Shervani Nausheen J.; 杉原 一司; 浅野 雅秀; 宇留野 晃; 海野 倫明; 高澤 伸; 岡本 宏; 菅原 明

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Nov. 2007

  
• The LC/MS-based glycoproteomic approach for unraveling the biological roles of glycans

  Sugahara Daisuke; Kaji Hiroyuki; Sugihara Kazushi; Asano Masahide; Narimatsu Hisashi

  Abstracts for Annual Meeting of Japanese Proteomics Society, 2012

  
• 6 IL-1ファミリーノックアウトマウスの解析 (8 サイトカイン・シグナル伝達機構の最近の進歩)

  岩倉 洋一郎; 宝来 玲子; 中江 進; 浅野 雅秀; 西城 忍

  アレルギー, 1999

  
• Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice (Journal of Clinical Investigation (2010) 120, 11, (3979-3995) DOI:10.1172/JCI42315)

  Wang F; Okamoto Y; Inoki I; Yoshioka K; Du W; Qi X; Takuwa N; Gonda K; Yamamoto Y; Ohkawa R; Nishiuchi T; Sugimoto N; Yatomi Y; Mitsumori K; Asano M; Kinoshita M; Takuwa Y

  Journal of Clinical Investigation, Mar. 2012, Peer-reviewed

  
• A degron system targeting endogenous PD-1 inhibits the growth of tumor cells in mice.

  Chie Naruse; Kazushi Sugihara; Tatsuhiko Miyazaki; Xuchi Pan; Fumihiro Sugiyama; Masahide Asano

  NAR cancer, Jun. 2022

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• Symmetrically dimethylated histone H3R2 promotes global transcription during minor zygotic genome activation in mouse pronuclei.

  Kohtaro Morita; Yuki Hatanaka; Shunya Ihashi; Masahide Asano; Kei Miyamoto; Kazuya Matsumoto

  Scientific reports, 12 May 2021, Peer-reviewed

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• α-Synuclein Spread from Olfactory Bulb Causes Hyposmia, Anxiety, and Memory Loss in BAC-SNCA Mice.

  Norihito Uemura; Jun Ueda; Toru Yoshihara; Masashi Ikuno; Maiko T Uemura; Hodaka Yamakado; Masahide Asano; John Q Trojanowski; Ryosuke Takahashi

  Movement disorders : official journal of the Movement Disorder Society, 06 Feb. 2021, Peer-reviewed

  
• Deficiency of the RIβ subunit of protein kinase A causes body tremor and impaired fear conditioning memory in rats.

  Hieu Hoang Trung; Toru Yoshihara; Akito Nakao; Katsumi Hayashida; Yoshiki Hirata; Koumei Shirasuna; Mitsuru Kuwamura; Yuki Nakagawa; Takehito Kaneko; Yasuo Mori; Masahide Asano; Takashi Kuramoto

  Scientific reports, 21 Jan. 2021, Peer-reviewed

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• Abnormal social behavior and altered gene expression in mice lacking NDRG2.

  Mika Takarada-Iemata; Toru Yoshihara; Nahoko Okitani; Keiko Iwata; Tsuyoshi Hattori; Hiroshi Ishii; Jureepon Roboon; Dinh Thi Nguyen; Qiyan Fan; Takashi Tamatani; Takumi Nishiuchi; Masahide Asano; Osamu Hori

  Neuroscience letters, 19 Jan. 2021, Peer-reviewed

  
• Involvement of NMDA receptors in tremor expression in Aspa/Hcn1 double-knockout rats.

  Ai Nishitani; Haruna Nagayoshi; Shigeo Takenaka; Masahide Asano; Saki Shimizu; Yukihiro Ohno; Takashi Kuramoto

  Experimental animals, 12 Nov. 2020, Peer-reviewed

  
• Various biological functions of carbohydrate chains learned from glycosyltransferase-deficient mice.

  Masahide Asano

  Experimental animals, 13 Apr. 2020, Peer-reviewed

  
• Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome.

  Mengnan Li; Shin-Ya Nishio; Chie Naruse; Meghan Riddell; Sabrina Sapski; Tatsuya Katsuno; Takao Hikita; Fatemeh Mizapourshafiyi; Fiona M Smith; Leanne T Cooper; Min Goo Lee; Masahide Asano; Thomas Boettger; Marcus Krueger; Astrid Wietelmann; Johannes Graumann; Bryan W Day; Andrew W Boyd; Stefan Offermanns; Shin-Ichiro Kitajiri; Shin-Ichi Usami; Masanori Nakayama

  Nature communications, 12 Mar. 2020, Peer-reviewed

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• Heterochromatin protein 1γ deficiency decreases histone H3K27 methylation in mouse neurosphere neuronal genes.

  Chie Naruse; Kanae Abe; Toru Yoshihara; Tomoaki Kato; Takumi Nishiuchi; Masahide Asano

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Mar. 2020, Peer-reviewed

  
• Author Correction: Efficient derivation of knock-out and knock-in rats using embryos obtained by in vitro fertilization.

  Arata Honda; Ryoma Tachibana; Kazuya Hamada; Kohtaro Morita; Naoaki Mizuno; Kento Morita; Masahide Asano

  Scientific reports, 30 Jan. 2020

  
• Efficient derivation of knock-out and knock-in rats using embryos obtained by in vitro fertilization.

  Honda A; Tachibana R; Hamada K; Morita K; Mizuno N; Morita K; Asano M

  Scientific reports, Aug. 2019, Peer-reviewed

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• Muscle weakness and impaired motor coordination in Hcn1-deficient rats.

  Nishitani A; Yoshihara T; Tanaka M; Kuwamura M; Asano M; Tsubota Y; Kuramoto T

  Experimental animals, Jul. 2019, Peer-reviewed

  
• Galactosyl carbohydrate residues on hematopoietic stem/progenitor cells are essential for homing and engraftment to the bone marrow.

  Soichiro Takagaki; Rieko Yamashita; Noriyoshi Hashimoto; Kazushi Sugihara; Kanako Kanari; Keisuke Tabata; Toshikazu Nishie; Shogo Oka; Masanori Miyanishi; Chie Naruse; Masahide Asano

  Scientific reports, 09 May 2019, Peer-reviewed

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• Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice.

  Yasuhiko Yamamoto; Mingkun Liang; Seiichi Munesue; Kisaburo Deguchi; Ai Harashima; Kazumi Furuhara; Teruko Yuhi; Jing Zhong; Shirin Akther; Hisanori Goto; Yuya Eguchi; Yasuko Kitao; Osamu Hori; Yoshitake Shiraishi; Noriyuki Ozaki; Yu Shimizu; Tomoya Kamide; Akifumi Yoshikawa; Yasuhiko Hayashi; Mitsutoshi Nakada; Olga Lopatina; Maria Gerasimenko; Yulia Komleva; Natalia Malinovskaya; Alla B Salmina; Masahide Asano; Katsuhiko Nishimori; Steven E Shoelson; Hiroshi Yamamoto; Haruhiro Higashida

  Communications biology, 2019, Peer-reviewed

  
• Loss of HCN1 subunits causes absence epilepsy in rats.

  Nishitani A; Kunisawa N; Sugimura T; Sato K; Yoshida Y; Suzuki T; Sakuma T; Yamamoto T; Asano M; Saito Y; Ohno Y; Kuramoto T

  Brain research, Nov. 2018, Peer-reviewed

  
• Lactosylceramide synthases encoded by B4galt5 and 6 genes are pivotal for neuronal generation and myelin formation in mice

  Toru Yoshihara; Hiroyuki Satake; Toshikazu Nishie; Nozomu Okino; Toshihisa Hatta; Hiroki Otani; Chie Naruse; Hiroshi Suzuki; Kazushi Sugihara; Eikichi Kamimura; Noriyo Tokuda; Keiko Furukawa; Koichi Fururkawa; Makoto Ito; Masahide Asano

  PLoS Genetics, Aug. 2018, Peer-reviewed

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• Characterization of Innate and Adaptive Immune Responses in PYNOD-Deficient Mice.

  Nakajima S; Imamura R; Yoshino M; Sakurai M; Tsuchiya K; Sugihara K; Asano M; Suda T

  ImmunoHorizons, Apr. 2018, Peer-reviewed

  
• New insights into the role of Jmjd3 and Utx in axial skeletal formation in mice

  Chie Naruse; Shinwa Shibata; Masaru Tamura; Takayuki Kawaguchi; Kanae Abe; Kazushi Sugihara; Tomoaki Kato; Takumi Nishiuchi; Shigeharu Wakana; Masahito Ikawa; Masahide Asano

  FASEB JOURNAL, Jun. 2017, Peer-reviewed

  
• Cbx3/HP1 gamma deficiency confers enhanced tumor-killing capacity on CD8(+) T cells

  Michael Sun; Ngoc Ha; Duc-Hung Pham; Megan Frederick; Bandana Sharma; Chie Naruse; Masahide Asano; Matthew E. Pipkin; Rani E. George; To-Ha Thai

  SCIENTIFIC REPORTS, Feb. 2017, Peer-reviewed

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• Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice

  Tokiharu Sato; Momoe Ishikawa; Toru Yoshihara; Ryota Nakazato; Haruhiro Higashida; Masahide Asano; Katsuji Yoshioka

  FEBS LETTERS, Sep. 2015, Peer-reviewed

  
• Major glycan structure underlying expression of the Lewis X epitope in the developing brain is O-mannose-linked glycans on phosphacan/RPTP beta

  Shohei Yaji; Hiroshi Manya; Naoki Nakagawa; Hiromu Takematsu; Tamao Endo; Reiji Kannagi; Toru Yoshihara; Masahide Asano; Shogo Oka

  GLYCOBIOLOGY, Apr. 2015, Peer-reviewed

  
• Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage

  Wenwen Wu; Hiroyuki Nishikawa; Takayo Fukudal; Vinayak Vittal; Masahide Asano; Yasuo Miyoshi; Rachel E. Klevit; Tomohiko Ohta

  CANCER RESEARCH, Apr. 2015, Peer-reviewed

  
• HP-1 gamma controls high-affinity antibody response to T-dependent antigens

  Ngoc Ha; Duc-Hung Pham; Aliakbar Shahsafaei; Chie Naruse; Masahide Asano; To-Ha Thai

  FRONTIERS IN IMMUNOLOGY, Jun. 2014, Peer-reviewed

  
• Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease

  Olga Lopatina; Toru Yoshihara; Tomoko Nishimura; Jing Zhong; Shirin Akther; Azam A. K. M. Fakhrul; Mingkun Liang; Chiharu Higashida; Kohei Sumi; Kazumi Furuhara; Yuki Inahata; Jian-Jung Huang; Keita Koizumi; Shigeru Yokoyama; Takahiro Tsuji; Yulia Petugina; Andrei Sumarokov; Alla B. Salmina; Koji Hashida; Yasuko Kitao; Osamu Hori; Masahide Asano; Yoji Kitamura; Takashi Kozaka; Kazuhiro Shiba; Fangfang Zhong; Min-Jue Xie; Makoto Sato; Katsuhiko Ishihara; Haruhiro Higashida

  FRONTIERS IN BEHAVIORAL NEUROSCIENCE, Apr. 2014, Peer-reviewed

  
• Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice

  Hong Cui; Yasuo Okamoto; Kazuaki Yoshioka; Wa Du; Noriko Takuwa; Wei Zhang; Masahide Asano; Toshishige Shibamoto; Yoh Takuwa

  Journal of Allergy and Clinical Immunology, Nov. 2013, Peer-reviewed

  
• Requirement of SLD5 for Early Embryogenesis

  Tomomi Mohri; Masaya Ueno; Yumi Nagahama; Zhi-Yuan Gong; Masahide Asano; Hiroko Oshima; Masanobu Oshima; Yasushi Fujio; Nobuyuki Takakura

  PLOS ONE, Nov. 2013, Peer-reviewed

  
• AP-1B-Mediated Protein Sorting Regulates Polarity and Proliferation of Intestinal Epithelial Cells in Mice

  Koji Hase; Fubito Nakatsu; Masumi Ohmae; Kazushi Sugihara; Noriko Shioda; Daisuke Takahashi; Yuuki Obata; Yukihiro Furusawa; Yumiko Fujimura; Taisuke Yamashita; Shinji Fukuda; Hiroshi Okamoto; Masahide Asano; Shigenobu Yonemura; Hiroshi Ohno

  GASTROENTEROLOGY, Sep. 2013, Peer-reviewed

  
• A replication-dependent passive mechanism modulates DNA demethylation in mouse primordial germ cells

  Rika Ohno; Megumi Nakayama; Chie Naruse; Naoki Okashita; Osamu Takano; Makoto Tachibana; Masahide Asano; Mitinori Saitou; Yoshiyuki Seki

  DEVELOPMENT, Jul. 2013, Peer-reviewed

  
• EXTL2, a Member of the EXT Family of Tumor Suppressors, Controls Glycosaminoglycan Biosynthesis in a Xylose Kinase-dependent Manner

  Satomi Nadanaka; Shaobo Zhou; Shoji Kagiyama; Naoko Shoji; Kazuyuki Sugahara; Kazushi Sugihara; Masahide Asano; Hiroshi Kitagawa

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2013, Peer-reviewed

  
• Displays of paternal mouse pup retrieval following communicative interaction with maternal mates

  Hong-Xiang Liu; Olga Lopatina; Chiharu Higashida; Hiroko Fujimoto; Shirin Akther; Alena Inzhutova; Mingkun Liang; Jing Zhong; Takahiro Tsuji; Toru Yoshihara; Kohei Sumi; Mizuho Ishiyama; Wen-Jie Ma; Mitsunori Ozaki; Satoshi Yagitani; Shigeru Yokoyama; Naofumi Mukaida; Takeshi Sakurai; Osamu Hori; Katsuji Yoshioka; Atsushi Hirao; Yukio Kato; Katsuhiko Ishihara; Ichiro Kato; Hiroshi Okamoto; Stanislav M. Cherepanov; Alla B. Salmina; Hirokazu Hirai; Masahide Asano; David A. Brown; Isamu Nagano; Haruhiro Higashida

  NATURE COMMUNICATIONS, Jan. 2013, Peer-reviewed

  
• Evidence that the EphA2 receptor exacerbates ischemic brain injury.

  John Thundyil; Silvia Manzanero; Dale Pavlovski; Tanya R Cully; Ker-Zhing Lok; Alexander Widiapradja; Prasad Chunduri; Dong-Gyu Jo; Chie Naruse; Masahide Asano; Bradley S Launikonis; Christopher G Sobey; Mark G Coulthard; Thiruma V Arumugam

  PloS one, 2013, Peer-reviewed

  
• Interleukin-1 (IL-1) may contribute to develop classical and alternative activation of microglia/macrophages after spinal cord injury

  Ohtaki Hirokazu; Sato Astushi; Tsumuraya Tomomi; Song Dandan; Miyamoto Kazuyuki; Ohara Kenji; Asano Masahide; Iwakura Yoichiro; Atsumi Takashi; Shioda Seiji

  JOURNAL OF NEUROIMMUNOLOGY, 15 Dec. 2012, Peer-reviewed

  
• Dopamine release via the vacuolar ATPase V0 sector c-subunit, confirmed in N18 neuroblastoma cells, results in behavioral recovery in hemiparkinsonian mice

  Duo Jin; Shin-ichi Muramatsu; Nobuaki Shimizu; Shigeru Yokoyama; Hirokazu Hirai; Kiyofumi Yamada; Hong-Xiang Liu; Chiharu Higashida; Minako Hashii; Akihiko Higashida; Masahide Asano; Shoji Ohkuma; Haruhiro Higashida

  NEUROCHEMISTRY INTERNATIONAL, Nov. 2012, Peer-reviewed

  
• Endothelial PI3K-C2 alpha, a class II PI3K, has an essential role in angiogenesis and vascular barrier function

  Kazuaki Yoshioka; Kotaro Yoshida; Hong Cui; Tomohiko Wakayama; Noriko Takuwa; Yasuo Okamoto; Wa Du; Xun Qi; Ken Asanuma; Kazushi Sugihara; Sho Aki; Hidekazu Miyazawa; Kuntal Biswas; Chisa Nagakura; Masaya Ueno; Shoichi Iseki; Robert J. Schwartz; Hiroshi Okamoto; Takehiko Sasaki; Osamu Matsui; Masahide Asano; Ralf H. Adams; Nobuyuki Takakura; Yoh Takuwa

  NATURE MEDICINE, Oct. 2012, Peer-reviewed

  
• Large-scale identification of target proteins of a glycosyltransferase isozyme by Lectin-IGOT-LC/MS, an LC/MS-based glycoproteomic approach

  Daisuke Sugahara; Hiroyuki Kaji; Kazushi Sugihara; Masahide Asano; Hisashi Narimatsu

  SCIENTIFIC REPORTS, Sep. 2012, Peer-reviewed

  
• Reduced Susceptibility to Colitis-Associated Colon Carcinogenesis in Mice Lacking Plasma Membrane-Associated Sialidase

  Kazunori Yamaguchi; Kazuhiro Shiozaki; Setsuko Moriya; Koichi Koseki; Tadashi Wada; Hiroo Tateno; Ikuro Sato; Masahide Asano; Yoichiro Iwakura; Taeko Miyagi

  PLOS ONE, Jul. 2012, Peer-reviewed

  
• Altered Oligosaccharide Structures Reduce Colitis Induction in Mice Defective in beta-1,4-Galactosyltransferase

  Shinichiro Shinzaki; Hideki Iijima; Hironobu Fujii; Eri Kuroki; Norika Tatsunaka; Takahiro Inoue; Sachiko Nakajima; Satoshi Egawa; Tatsuya Kanto; Masahiko Tsujii; Eiichi Morii; Shunsaku Takeishi; Masahide Asano; Tetsuo Takehara; Norio Hayashi; Eiji Miyoshi

  GASTROENTEROLOGY, May 2012, Peer-reviewed

  
• Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury.

  Atsushi Sato; Hirokazu Ohtaki; Tomomi Tsumuraya; Dandan Song; Kenji Ohara; Masahide Asano; Yoichiro Iwakura; Takashi Atsumi; Seiji Shioda

  Journal of neuroinflammation, 07 Apr. 2012, Peer-reviewed

  
• Glycoprotein Hyposialylation Gives Rise to a Nephrotic-Like Syndrome That Is Prevented by Sialic Acid Administration in GNE V572L Point-Mutant Mice

  Mitutoshi Ito; Kazushi Sugihara; Tomoya Asaka; Tadashi Toyama; Toru Yoshihara; Kengo Furuichi; Takashi Wada; Masahide Asano

  PLOS ONE, Jan. 2012, Peer-reviewed

  
• Loss of Heterochromatin Protein 1 Gamma Reduces the Number of Primordial Germ Cells via Impaired Cell Cycle Progression in Mice

  Kanae Abe; Chie Naruse; Tomoaki Kato; Takumi Nishiuchi; Mitinori Saitou; Masahide Asano

  BIOLOGY OF REPRODUCTION, Nov. 2011, Peer-reviewed

  
• HP1 gamma links histone methylation marks to meiotic synapsis in mice

  Yuki Takada; Chie Naruse; Yael Costa; Takayuki Shirakawa; Makoto Tachibana; Jafar Sharif; Fuyuko Kezuka-Shiotani; Dai Kakiuchi; Hiroshi Masumoto; Yo-ichi Shinkai; Kazuyuki Ohbo; Antoine H. F. M. Peters; James M. A. Turner; Masahide Asano; Haruhiko Koseki

  DEVELOPMENT, Oct. 2011, Peer-reviewed

  
• Specific Enzyme Complex of beta-1,4-Galactosyltransferase-II and Glucuronyltransferase-P Facilitates Biosynthesis of N-linked Human Natural Killer-1 (HNK-1) Carbohydrate

  Tetsuya Kouno; Yasuhiko Kizuka; Naoki Nakagawa; Toru Yoshihara; Masahide Asano; Shogo Oka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2011, Peer-reviewed

  
• Septic Shock Is Associated with Receptor for Advanced Glycation End Products Ligation of LPS

  Yasuhiko Yamamoto; Ai Harashima; Hidehito Saito; Koichi Tsuneyama; Seiichi Munesue; So Motoyoshi; Dong Han; Takuo Watanabe; Masahide Asano; Shin Takasawa; Hiroshi Okamoto; Satoshi Shimura; Tadahiro Karasawa; Hideto Yonekura; Hiroshi Yamamoto

  JOURNAL OF IMMUNOLOGY, Mar. 2011, Peer-reviewed

  
• ガラクトース転移酵素の欠損は、実験的腸炎を軽減させる(Amelioration of murine experimental colitis by deficiency of galactosyltransferase activity)

  新崎 信一郎; 飯島 英樹; 黒木 絵莉; 竜中 法佳; 浅野 雅秀; 林 紀夫; 三善 英知

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010

  
• HNK-1糖鎖の生合成過程におけるbeta4-galactosyltransferase-IIの役割

  河野 哲也; 木塚 康彦; 吉原 亨; 浅野 雅秀; 岡 昌吾

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010

  
• Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice

  Fei Wang; Yasuo Okamoto; Isao Inoki; Kazuaki Yoshioka; Wa Du; Xun Qi; Noriko Takuwa; Koichi Gonda; Yasuhiko Yamamoto; Ryunosuke Ohkawa; Takumi Nishiuchi; Naotoshi Sugimoto; Yutaka Yatomi; Kunitoshi Mitsumori; Masahide Asano; Makoto Kinoshita; Yoh Takuwa

  Journal of Clinical Investigation, 01 Nov. 2010, Peer-reviewed

  
• beta 4-Galactosyltransferase-5 is a lactosylceramide synthase essential for mouse extra-embryonic development

  Toshikazu Nishie; Yoko Hikimochi; Kota Zama; Yoshiyasu Fukusumi; Mitutoshi Ito; Haruka Yokoyama; Chie Naruse; Makoto Ito; Masahide Asano

  GLYCOBIOLOGY, Oct. 2010, Peer-reviewed

  
• Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver

  Tomoko Sugiura; Sayaka Kato; Takuya Shimizu; Tomohiko Wakayama; Noritaka Nakamichi; Yoshiyuki Kubo; Daisuke Iwata; Kazuhiro Suzuki; Tomoyoshi Soga; Masahide Asano; Shoichi Iseki; Ikumi Tamai; Akira Tsuji; Yukio Kato

  DRUG METABOLISM AND DISPOSITION, Oct. 2010, Peer-reviewed

  
• Gene Knockout and Metabolome Analysis of Carnitine/Organic Cation Transporter OCTN1

  Yukio Kato; Yoshiyuki Kubo; Daisuke Iwata; Sayaka Kato; Tomohisa Sudo; Tomoko Sugiura; Takashi Kagaya; Tomohiko Wakayama; Akiyoshi Hirayama; Masahiro Sugimoto; Kazushi Sugihara; Shuichi Kaneko; Tomoyoshi Soga; Masahide Asano; Masaru Tomita; Toshiyuki Matsui; Morimasa Wada; Akira Tsuji

  PHARMACEUTICAL RESEARCH, May 2010, Peer-reviewed

  
• Impairment of Embryonic Cell Division and Glycosaminoglycan Biosynthesis in Glucuronyltransferase-I-deficient Mice

  Tomomi Izumikawa; Nao Kanagawa; Yukiko Watamoto; Megumi Okada; Mika Saeki; Masahiro Sakano; Kazuyuki Sugahara; Kazushi Sugihara; Masahide Asano; Hiroshi Kitagawa

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2010, Peer-reviewed

  
• Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T

  Yiqing Zhao; Xiaodong Zhang; Kishore Guda; Earl Lawrence; Qun Sun; Toshio Watanabe; Yoichiro Iwakura; Masahide Asano; Lanlan Wei; Zhirong Yang; Weiping Zheng; Dawn Dawson; Joseph Willis; Sanford D. Markowitz; Masanobu Satake; Zhenghe Wang

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 2010, Peer-reviewed

  
• S1P(2), the G Protein-Coupled Receptor for Sphingosine-1-Phosphate, Negatively Regulates Tumor Angiogenesis and Tumor Growth In vivo in Mice

  Wa Du; Noriko Takuwa; Kazuaki Yoshioka; Yasuo Okamoto; Koichi Gonda; Kazushi Sugihara; Akiyoshi Fukamizu; Masahide Asano; Yoh Takuwa

  CANCER RESEARCH, Jan. 2010, Peer-reviewed

  
• Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin

  Akira Tamase; Teruyuki Muraguchi; Kazuhito Naka; Shingo Tanaka; Masashi Kinoshita; Takayuki Hoshii; Masako Ohmura; Haruhiko Shugo; Takako Ooshio; Mitsutoshi Nakada; Kazunobu Sawamoto; Masafumi Onodera; Kunio Matsumoto; Masanobu Oshima; Masahide Asano; Hideyuki Saya; Hideyuki Okano; Toshio Suda; Jun-ichiro Hamada; Atsushi Hirao

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 2009, Peer-reviewed

  
• Learning/Memory Impairment and Reduced Expression of the HNK-1 Carbohydrate in beta 4-Galactosyltransferase-II-deficient Mice

  Toru Yoshihara; Kazushi Sugihara; Yasuhiko Kizuka; Shogo Oka; Masahide Asano

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2009, Peer-reviewed

  
• Bidirectional Signaling through EphrinA2-EphA2 Enhances Osteoclastogenesis and Suppresses Osteoblastogenesis

  Naoko Irie; Yasunari Takada; Yoshihiko Watanabe; Yumi Matsuzaki; Chie Naruse; Masahide Asano; Yoichiro Iwakura; Toshio Suda; Koichi Matsuo

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2009, Peer-reviewed

  
• Important role of heparan sulfate in postnatal islet growth and insulin secretion

  Iwao Takahashi; Naoya Noguchi; Koji Nata; Shuhei Yamada; Tomoyuki Kaneiwa; Shuji Mizumoto; Takayuki Ikeda; Kazushi Sugihara; Masahide Asano; Takeo Yoshikawa; Akiyo Yamauchi; Nausheen Jamal Shervani; Akira Uruno; Ichiro Kato; Michiaki Unno; Kazuyuki Sugahara; Shin Takasawa; Hiroshi Okamoto; Akira Sugawara

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2009, Peer-reviewed

  
• Both alleles of PSF1 are required for maintenance of pool size of immature hematopoietic cells and acute bone marrow regeneration

  Masaya Ueno; Machiko Itoh; Kazushi Sugihara; Masahide Asano; Nobuyuki Takakura

  BLOOD, Jan. 2009, Peer-reviewed

  
• Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome

  Chi-Bun Chan; Michiyo Abe; Noriyoshi Hashimoto; Chunhai Hao; Ifor R. Williams; Xia Liu; Shinji Nakao; Akitsugu Yamamoto; Shi-Yong Li; Ikuko Hara-Nishimura; Masahide Asano; Keqiang Ye

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 2009, Peer-reviewed

  
• Ablation of the scaffold protein JLP causes reduced fertility in male mice

  Asuka Iwanaga; Guangmin Wang; Davaakhuu Gantulga; Tokiharu Sato; Tuvshintugs Baljinnyam; Keiko Shimizu; Ken Takumi; Motoharu Hayashi; Takuya Akashi; Hideki Fuse; Kazushi Sugihara; Masahide Asano; Katsuji Yoshioka

  TRANSGENIC RESEARCH, Dec. 2008, Peer-reviewed

  
• The scaffold protein JSAP1 regulates proliferation and differentiation of cerebellar granule cell precursors by modulating JNK signaling

  Tokiharu Sato; Takashi Torashima; Kazushi Sugihara; Hirokazu Hirai; Masahide Asano; Katsuji Yoshioka

  MOLECULAR AND CELLULAR NEUROSCIENCE, Nov. 2008, Peer-reviewed

  
• Serological evidence for hepatitis E virus infection in laboratory monkeys and pigs in animal facilities in Japan

  Hiroshi Yamamoto; Tian-Cheng Li; Chihiro Koshimoto; Kaori Ito; Masakazu Kita; Nobumoto Miyashita; Jiro Arikawa; Kenichi Yagami; Masahide Asano; Hideo Tezuka; Noboru Suzuki; Tsutomu Kurosawa; Toshiyuki Shibahara; Masato Furuya; Shirou Mohri; Hiroshi Sato; Kazutaka Ohsawa; Kentaro Ibuki; Naokazu Takeda

  EXPERIMENTAL ANIMALS, Jul. 2008, Peer-reviewed

  
• Wtap is required for differentiation of endoderm and mesoderm in the mouse embryo

  Yoshiyasu Fukusumi; Chie Naruse; Masahide Asano

  DEVELOPMENTAL DYNAMICS, Mar. 2008, Peer-reviewed

  
• Neuroprotective actions of PIKE-L by inhibition of SET proteolytic degradation by asparagine endopeptidase

  Zhixue Liu; Sung-Wuk Jang; Xia Liu; Dongmei Cheng; Junmin Peng; Manuel Yepes; Xiao-jiang Li; Steve Matthews; Colin Watts; Masahicle Asano; Ikuko Hara-Nishimura; Hongbo R. Luo; Keqiang Ye

  MOLECULAR CELL, Mar. 2008, Peer-reviewed

  
• A novel beta-myosin heavy chain gene mutation, p.Met531Arg, identified in isolated left ventricular non-compaction in humans, results in left ventricular hypertrophy that progresses to dilation in a mouse model

  Tomoya Kaneda; Chie Naruse; Atsuhiro Kawashima; Noboru Fujino; Toru Oshima; Masanobu Namura; Shinichi Nunoda; Sumio Mori; Tetsuo Konno; Hidekazu Ino; Masakazu Yamagishi; Masahide Asano

  CLINICAL SCIENCE, Mar. 2008, Peer-reviewed

  
• EphA2 is an essential mediator of UV radiation-induced apoptosis

  Guoqi Zhang; Ching-Ni Njaw; Jong Min Park; Chie Naruse; Masahide Asano; Hensin Tsao

  CANCER RESEARCH, Mar. 2008, Peer-reviewed

  
• Suppressive role of leukocyte cell-derived chernotaxin 2 in mouse anti-type II collagen antibody-induced arthritis

  Akinori Okumura; Takeshi Saito; Isao Otani; Kazuo Kojima; Yasunori Yamada; Akiko Ishida-Okawara; Katsuyoshi Nakazato; Masahide Asano; Kiichi Kanayama; Yoichiro Iwakura; Kazuo Suzuki; Satoshi Yamagoe

  ARTHRITIS AND RHEUMATISM, Feb. 2008, Peer-reviewed

  
• Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death

  Asuka Iwanaga; Tokiharu Sato; Kazushi Sugihara; Atsushi Hirao; Nobuyuki Takakura; Hiroshi Okamoto; Masahide Asano; Katsuji Yoshioka

  NEUROSCIENCE LETTERS, Dec. 2007, Peer-reviewed

  
• 学習・記憶の制御における糖鎖の役割

  浅野 雅秀; 吉原 亨; 杉原 一司; 木塚 康彦; 岡 昌吾; 成瀬 智恵; 阿部 可奈恵

  金沢大学十全医学会雑誌, Sep. 2007

  
• A novel gene trapping for identifying genes expressed under the control of specific transcription factors

  Chie Naruse; Yoshiyasu Fukusumi; Dai Kakiuchi; Masahide Asano

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2007, Peer-reviewed

  
• Corrigendum to "Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells" [FEBS Lett. 581 (2007) 1417-1424] (DOI:10.1016/j.febslet.2007.02.064)

  Yoshikata Morita; Hisazumi Araki; Toshiro Sugimoto; Keisuke Takeuchi; Takuya Yamane; Toshinaga Maeda; Yoshio Yamamoto; Katsuji Nishi; Masahide Asano; Kanae Shirahama-Noda; Mikio Nishimura; Takashi Uzu; Ikuko Hara-Nishimura; Daisuke Koya; Atsunori Kashiwagi; Iwao Ohkubo

  FEBS Letters, 24 Jul. 2007, Peer-reviewed

  
• Legumain/asparaginyl endopeptidase controls extracellular matrix remodeling through the degradation of fibronectin in mouse renal proximal tubular cells

  Yoshikata Morita; Hisazumi Araki; Toshiro Sugimoto; Keisuke Takeuchi; Takuya Yamane; Toshinaga Maeda; Yoshio Yamamoto; Katsuji Nishi; Masahide Asano; Kanae Shirahama-Noda; Mikio Nishimura; Takashi Uzu; Ikuko Hara-Nishimura; Daisuke Koya; Atsunori Kashiwagi; Iwao Ohkubo

  FEBS LETTERS, Apr. 2007, Peer-reviewed

  
• CD38 is critical for social behaviour by regulating oxytocin secretion

  Duo Jin; Hong-Xiang Liu; Hirokazu Hirai; Takashi Torashima; Taku Nagai; Olga Lopatina; Natalia A. Shnayder; Kiyofumi Yamada; Mami Noda; Toshihiro Seike; Kyota Fujita; Shin Takasawa; Shigeru Yokoyama; Keita Koizumi; Yoshitake Shiraishi; Shigenori Tanaka; Minako Hashii; Toru Yoshihara; Kazuhiro Higashida; Mohammad Saharul Islam; Nobuaki Yamada; Kenshi Hayashi; Naoya Noguchi; Ichiro Kato; Hiroshi Okamoto; Akihiro Matsushima; Alla Salmina; Toshio Munesue; Nobuaki Shimizu; Sumiko Mochida; Masahide Asano; Haruhiro Higashida

  NATURE, Mar. 2007, Peer-reviewed

  
• Development of immunoglobulin A nephropathy-like disease in beta-1,4-galactosyltransferase-I-deficient mice

  Toshikazu Nishie; Osamu Miyaishi; Haruhito Azuma; Akihiko Kameyama; Chile Naruse; Noriyoshi Hashimoto; Hitoshi Yokoyama; Hisashi Narimatsu; Takashi Wada; Masahide Asano

  AMERICAN JOURNAL OF PATHOLOGY, Feb. 2007, Peer-reviewed

  
• Development of IgA nephropathy-like disease with high serum IgA levels and increased proportion of polymeric IgA in beta-1,4-galactosyltransferase-deficient mice

  Toshikazu Nishie; Osamu Miyaishi; Haruhito Azuma; Akihiko Kameyama; Chie Naruse; Noriyoshi Hashimoto; Hitoshi Yokoyama; Hisashi Narimatsu; Takashi Wada; Masahide Asano

  IGA NEPHROPATHY TODAY, 2007, Peer-reviewed

  
• Analysis of molecular mechanisms of IgA nephropathy in β-1,4- galactosyltransferase-I-deficient mice

  Toshikazu Nishie; Renhua; Kazuma Ogawa; Kazuhiro Shiba; Hirofumi Mori; Takashi Wada; Masahide Asano

  Nephrology, Oct. 2006, Peer-reviewed

  
• Interleukin-1-dependent sequential chemokine expression and inflammatory cell infiltration in ischemia-reperfusion injury

  Kengo Furuichi; Takashi Wada; Yasunori Iwata; Satoshi Kokubo; Akinori Hara; Junya Yamahana; Takeshi Sugaya; Yoichiro Iwakura; Kouji Matsushima; Masahide Asano; Hitoshi Yokoyama; Shuichi Kaneko

  CRITICAL CARE MEDICINE, Sep. 2006, Peer-reviewed

  
• RAGE control of diabetic nephropathy in a mouse model - Effects of RAGE gene disruption and administration of low-molecular weight heparin

  Khin-Mar Myint; Yasuhiko Yamamoto; Toshio Doi; Ichiro Kato; Ai Harashima; Hideto Yonekura; Takuo Watanabe; Harumichi Shinohara; Masayoshi Takeuchi; Koichi Tsuneyama; Noriyoshi Hashimoto; Masahide Asano; Shin Takasawa; Hiroshi Okamoto; Hiroshi Yamamoto

  DIABETES, Sep. 2006, Peer-reviewed

  
• Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in developing and adult mouse brain

  E Miura; M Fukaya; T Sato; K Sugihara; M Asano; K Yoshioka; M Watanabe

  JOURNAL OF NEUROCHEMISTRY, Jun. 2006, Peer-reviewed

  
• Expression and distribution of JNK/SAPK-associated scaffold protein JSAP1 in mouse brain

  Miura Eriko; Fukaya Masahiro; Sato Tokiharu; Sugihara Kazushi; Asano Masahide; Yoshioka Katsuji; Watanabe Masahiko

  NEUROSCIENCE RESEARCH, 2006, Peer-reviewed

  
• Early increase in mRNA levels of pro-inflammatory cytokines and their interactions in the mouse hippocampus after transient global ischemia

  YY Zhu; K Saito; Y Murakami; M Asano; Y Iwakura; M Seishima

  NEUROSCIENCE LETTERS, Jan. 2006, Peer-reviewed

  
• Impairment of cardiomyogenesis in embryonic stem cells lacking scaffold protein JSAP1

  T Sato; K Hidaka; A Iwanaga; M Ito; M Asano; Y Nakabeppu; T Morisaki; K Yoshioka

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2005, Peer-reviewed

  
• PSF1 is essential for early embryogenesis in mice

  M Ueno; M Itoh; LY Kong; K Sugihara; M Asano; N Takakura

  MOLECULAR AND CELLULAR BIOLOGY, Dec. 2005, Peer-reviewed

  
• Identification of Zfp-57 as a downstream molecule of STAT3 and Oct-3/4 in embryonic stem cells

  T Akagi; M Usuda; T Matsuda; MSH Ko; H Niwa; M Asano; H Koide; T Yokota

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2005, Peer-reviewed

  
• Receptor for advanced glycation end products is a promising target of diabetic nephropathy

  Y Yamamoto; T Doi; Kato, I; H Shinohara; S Sakurai; H Yonekura; T Watanabe; KM Myint; A Harashima; M Takeuchi; S Takasawa; H Okamoto; N Hashimoto; M Asano; H Yamamoto

  MAILLARD REACTION: CHEMISTRY AT THE INTERFACE OF NUTRITION, AGING, AND DISEASE, 2005, Peer-reviewed

  
• Interleukin (IL)-6, but not IL-1, induction in the brain downstream of cyclooxygenase-2 is essential for the induction of febrile response against peripheral IL-1 alpha

  K Kagiwada; D Chida; T Sakatani; M Asano; A Nambu; S Kakuta; Y Iwakura

  ENDOCRINOLOGY, Nov. 2004, Peer-reviewed

  
• Involvement of IL-17 in Fas ligand-induced inflammation

  M Umemura; T Kawabe; K Shudo; H Kidoya; M Fukui; M Asano; Y Iwakura; G Matsuzaki; R Imamura; T Suda

  INTERNATIONAL IMMUNOLOGY, Aug. 2004, Peer-reviewed

  
• Involvement of interleukin-6 and tumor necrosis factor alpha in CYP3A11 and 2C29 down-regulation by Bacillus Calmette-Guerin and lipopolysaccharide in mouse liver

  T Ashino; T Oguro; S Shioda; R Horai; M Asano; K Sekikawa; Y Iwakura; S Numazawa; T Yoshida

  DRUG METABOLISM AND DISPOSITION, Jul. 2004, Peer-reviewed

  
• Increase in hepatic NKT cells in leukocyte cell-derived chemotaxin 2-deficient mice contributes to severe concanavalin A-induced hepatitis

  T Saito; A Okumura; H Watanabe; M Asano; A Ishida-Okawara; J Sakagami; K Sudo; Y Hatano-Yokoe; JS Bezbradica; S Joyce; T Abo; Y Iwakura; K Suzuki; S Yamagoe

  JOURNAL OF IMMUNOLOGY, Jul. 2004, Peer-reviewed

  
• Blockade of CCR2 ameliorates progressive fibrosis in kidney

  K Kitagawa; T Wada; K Furuichi; H Hashimoto; Y Ishiwata; M Asano; M Takeya; WA Kuziel; K Matsushima; N Mukaida; H Yokoyama

  AMERICAN JOURNAL OF PATHOLOGY, Jul. 2004, Peer-reviewed

  
• Polylactosamine synthesis and branch formation of N-glycans in beta 1,4-galactosyltransferase-1-deficient mice

  N Kotani; M Asano; N Inoue; Y Iwakura; S Takasaki

  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Jun. 2004, Peer-reviewed

  
• Impairment of skin wound healing in beta-1,4-galactosyltransferase-deficient mice with reduced leukocyte recruitment

  R Mori; T Kondo; T Nishie; T Ohshima; M Asano

  AMERICAN JOURNAL OF PATHOLOGY, Apr. 2004, Peer-reviewed

  
• Essential roles of Meltrin beta (ADAM19) in heart development

  K Kurohara; K Komatsu; T Kurisaki; A Masuda; N Irie; M Asano; K Sudo; Y Nabeshima; Y Iwakura; A Sehara-Fujisawa

  DEVELOPMENTAL BIOLOGY, Mar. 2004, Peer-reviewed

  
• The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic beta-cell differentiation

  JF Wang; L Elghazi; SE Parker; H Kizilocak; M Asano; L Sussel; B Sosa-Pineda

  DEVELOPMENTAL BIOLOGY, Feb. 2004, Peer-reviewed

  
• Acetyl-L-carnitine permeability across the blood-brain barrier and involvement of carnitine transporter OCTN2

  A Inano; Y Sai; H Nikaido; N Hasimoto; M Asano; A Tsuji; Tamai, I

  BIOPHARMACEUTICS & DRUG DISPOSITION, Nov. 2003, Peer-reviewed

  
• CCR2 signaling contributes to ischemia-reperfusion injury in kidney

  K Furuichi; T Wada; Y Iwata; K Kitagawa; KI Kobayashi; H Hashimoto; Y Ishiwata; M Asano; H Wang; K Matsushima; M Takeya; WA Kuziel; N Mukaida; H Yokoyama

  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Oct. 2003, Peer-reviewed

  
• Impaired selectin-ligand biosynthesis and reduced inflammatory responses in beta-1,4-galactosyltransferdse-I-deficient mice

  M Asano; S Nakae; N Kotani; N Shirafuji; A Nambu; N Hashimoto; H Kawashima; M Hirose; M Miyasaka; S Takasaki; Y Iwakura

  BLOOD, Sep. 2003, Peer-reviewed

  
• Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/F3 subgroup

  Y Takeda; K Akasaka; S Lee; S Kobayashi; H Kawano; S Murayama; N Takahashi; K Hashimoto; M Kano; M Asano; K Sudo; Y Iwakura; K Watanabe

  JOURNAL OF NEUROBIOLOGY, Sep. 2003, Peer-reviewed

  
• Biosynthetic processing of cathepsins and lysosomal degradation are abolished in asparaginyl endopeptidase-deficient mice

  K Shirahama-Noda; A Yamamoto; K Sugihara; N Hashimoto; M Asano; M Nishimura; Hara-Nishimura, I

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2003, Peer-reviewed

  
• Lack of interleukin-1 beta decreases the severity of atherosclerosis in ApoE-deficient mice

  H Kirii; T Niwa; Y Yamada; H Wada; K Saito; Y Iwakura; M Asano; H Moriwaki; M Seishima

  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, Apr. 2003, Peer-reviewed

  
• IL-1 is required for allergen-specific T(h)2 cell activation and the development of airway hypersensitivity response

  S Nakae; Y Komiyama; H Yokoyama; A Nambu; M Umeda; M Iwase; Homma, I; K Sudo; R Horai; M Asano; Y Iwakura

  INTERNATIONAL IMMUNOLOGY, Apr. 2003, Peer-reviewed

  
• Suppression of oxidative neuronal damage after transient middle cerebral artery occlusion in mice lacking interleukin-1.

  Hirokazu Ohtaki; Hisayuki Funahashi; Kenji Dohi; Takiko Oguro; Reiko Horai; Masahide Asano; Yoichiro Iwakura; Li Yin; Masaji Matsunaga; Noboru Goto; Seiji Shioda

  Neuroscience research, Mar. 2003, Peer-reviewed

  
• Aberrant responses to acoustic stimuli in mice deficient for neural recognition molecule NB-2

  H Li; Y Takeda; H Niki; J Ogawa; S Kobayashi; N Kai; K Akasaka; M Asano; K Sudo; Y Iwakura; K Watanabe

  EUROPEAN JOURNAL OF NEUROSCIENCE, Mar. 2003, Peer-reviewed

  
• IL-1-induced tumor necrosis factor-alpha elicits inflammatory cell infiltration in the skin by inducing IFN-gamma-inducible protein 10 in the elicitation phase of the contact hypersensitivity response

  S Nakae; Y Komiyama; S Narumi; K Sudo; R Horai; Y Tagawa; K Sekikawa; K Matsushima; M Asano; Y Iwakura

  INTERNATIONAL IMMUNOLOGY, Feb. 2003, Peer-reviewed

  
• Phenotypic analysis of Meltrin alpha (ADAM12)-deficient mice: Involvement of Meltrin alpha in adipogenesis and myogenesis

  T Kurisaki; A Masuda; K Sudo; J Sakagami; S Higashiyama; Y Matsuda; A Nagabukuro; A Tsuji; Y Nabeshima; M Asano; Y Iwakura; A Sehara-Fujisawa

  MOLECULAR AND CELLULAR BIOLOGY, Jan. 2003, Peer-reviewed

  
• Ex vivo whole-embryo culture of caspase-8-deficient embryos normalize their aberrant phenotypes in the developing neural tube and heart

  K Sakamaki; T Inoue; M Asano; K Sudo; H Kazama; J Sakagami; S Sakata; M Ozaki; S Nakamura; S Toyokuni; N Osumi; Y Iwakura; S Yonehara

  CELL DEATH AND DIFFERENTIATION, Nov. 2002, Peer-reviewed

  
• Antigen-specific T cell Sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses

  S Nakae; Y Komiyama; A Nambu; K Sudo; M Iwase; Homma, I; K Sekikawa; M Asano; Y Iwakura

  IMMUNITY, Sep. 2002, Peer-reviewed

  
• Mice deficient in nervous system-specific carbohydrate epitope HNK-1 exhibit impaired synaptic plasticity and spatial learning

  S Yamamoto; S Oka; M Inoue; M Shimuta; T Manabe; M Takahashi; M Miyamoto; M Asano; J Sakagami; K Sudo; Y Iwakura; K Ono; T Kawasaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2002, Peer-reviewed

  
• Reduced postischemic apoptosis in the hippocampus of mice deficient in interleukin-1.

  Hidekatsu Mizushima; Cheng J i Zhou; Kenji Dohi; Reiko Horai; Masahide Asano; Yoichiro Iwakura; Takahiro Hirabayashi; Satoru Arata; Shigeo Nakajo; Atsushi Takaki; Hirokazu Ohtaki; Seiji Shioda

  The Journal of comparative neurology, 24 Jun. 2002, Peer-reviewed

  
• Involvement of tumor necrosis factor alpha, rather than interleukin-1 alpha/beta or nitric oxides in the heme oxygenase-1 gene expression by lipopolysaccharide in the mouse liver

  T Oguro; Y Takahashi; T Ashino; A Takaki; S Shioda; R Horai; M Asano; K Sekikawa; Y Iwakura; T Yoshida

  FEBS LETTERS, Apr. 2002, Peer-reviewed

  
• Suppression of autoimmune arthritis in interleukin-1-deficient mice in which T cell activation is impaired due to low levels of CD40 ligand and OX40 expression on T cells

  S Saijo; M Asano; R Horai; H Yamamoto; Y Iwakura

  ARTHRITIS AND RHEUMATISM, Feb. 2002, Peer-reviewed

  
• Increased expression of interleukin-1β in mouse hippocampus after global cerebral ischemia

  Yoichi Imaizumi; Hidekatsu Mizushima; Hiroaki Matsumoto; Kenji Dohi; Kiyoshi Matsumoto; Hirokazu Ohtaki; Hisayuki Funahashi; Seiji Matsunaga; Reiko Horai; Masahide Asano; Yoichiro Iwakura; Seiji Shioda

  Acta Histochemica et Cytochemica, Oct. 2001, Peer-reviewed

  
• Role of IL-1α and IL-1β in ischemic brain damage

  H. Boutin; R. A. LeFeuvre; R. Horai; M. Asano; Y. Iwakura; N. J. Rothwell

  Journal of Neuroscience, 01 Aug. 2001, Peer-reviewed

  
• Knockout of mouse β1,4-galactosyltransferase-1 gene results in a dramatic shift of outer chain moieties of N-glycans from type 2 to type 1 chains in hepatic membrane and plasma glycoproteins

  N. Kotani; M. Asano; Y. Iwakura; S. Takasaki

  Biochemical Journal, 01 Aug. 2001, Peer-reviewed

  
• IL-1 enhances T cell-dependent antibody production through induction of CD40 ligand and OX40 on T cells

  S. Nakae; M. Asano; R. Horai; N. Sakaguchi; Y. Iwakura

  Journal of Immunology, 01 Jul. 2001, Peer-reviewed

  
• Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development

  H Ozaki; Y Watanabe; K Takahashi; K Kitamura; A Tanaka; K Urase; T Momoi; K Sudo; J Sakagami; M Asano; Y Iwakura; K Kawakami

  MOLECULAR AND CELLULAR BIOLOGY, May 2001, Peer-reviewed

  
• Caspase-2 deficiency prevents programmed germ cell death resulting from cytokine insufficiency but not meiotic defects caused by loss of ataxia telangiectasia-mutated (Atm) gene function

  Y. Morita; D. V. Maravei; L. Bergeron; S. Wang; G. I. Perez; O. Tsutsumi; Y. Taketani; M. Asano; R. Horai; S. J. Korsmeyer; Y. Iwakura; J. Yuan; J. L. Tilly

  Cell Death and Differentiation, 2001, Peer-reviewed

  
• Tag-1-deficient mice have marked elevation of adenosine A1 receptors in the hippocampus

  Fumihiko Fukamauchi; Okihiko Aihara; Yi-Jun Wang; Keiko Akasaka; Yasuo Takeda; Masao Horie; Hitoshi Kawano; Katsuko Sudo; Masahide Asano; Kazutada Watanabe; Yoichiro Iwakura

  Biochemical and Biophysical Research Communications, 2001, Peer-reviewed

  
• IL-1α, but not IL-1Β, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity

  Susumu Nakae; Chie Naruse-Nakajimal; Katsuko Sudo; Reiko Horai; Masahide Asano; Yoichiro Iwakura

  International Immunology, 2001, Peer-reviewed

  
• Involvement of EphA2 in the formation of the tail notochord via interaction with ephrinA1

  Chie Naruse-Nakajima; Masahide Asano; Yoichiro Iwakura

  Mechanisms of Development, 2001, Peer-reviewed

  
• Interleukin-1β, but not interleukin-1α, is required for T-cell-dependent antibody production

  Susumu Nakae; Masahide Asano; Reiko Horai; Yoichiro Iwakura

  Immunology, 2001, Peer-reviewed

  
• Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells

  K. Hayashi; W. Natsume; T. Watanabe; N. Abe; N. Iwai; H. Okada; Y. Ito; M. Asano; Y. Iwakura; S. Habu; Y. Takahama; M. Satake

  Journal of Immunology, 15 Dec. 2000, Peer-reviewed

  
• Mutually exclusive expression of odorant receptor transgenes

  S Serizawa; T Ishii; H Nakatani; A Tsuboi; F Nagawa; M Asano; K Sudo; J Sakagami; H Sakano; T Ijiri; Y Matsuda; M Suzuki; T Yamamori; Y Iwakura; H Sakano

  NATURE NEUROSCIENCE, Jul. 2000, Peer-reviewed

  
• Impaired learning with enhanced hippocampal long-term potentiation in PTPδ-deficient mice

  Noriko Uetani; Kunio Kato; Hiro Ogura; Kazuya Mizuno; Kano Kawano; Katsuhiko Mikoshiba; Hidetaka Yakura; Masahide Asano; Yoichiro Iwakura

  EMBO Journal, 15 Jun. 2000, Peer-reviewed

  
• Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin I receptor antagonist-deficient mice

  Reiko Horai; Shinobu Saijo; Hidetoshi Tanioka; Susumu Nakae; Katsuko Sudo; Akihiko Okahara; Toshimi Ikuse; Masahide Asano; Yoichiro Iwakura

  Journal of Experimental Medicine, 17 Jan. 2000, Peer-reviewed

  
• Lipopolysaccharide-induced HIV-1 expression in transgenic mice is mediated by tumor necrosis factor-α and interleukin-1, but not by interferon-γ nor interleukin-6

  Jun Tanaka; Hidenori Ozaki; Jiro Yasuda; Reiko Horai; Yoichi Tagawa; Masahide Asano; Shinobu Saijo; Mitsunobu Imai; Kenji Sekikawa; Manfred Kopf; Yoichiro Iwakura

  AIDS, 2000, Peer-reviewed

  
• Presence of a higher molecular weight β-1,4-galactosyltransferase in mouse liver

  Masahiro Kido; Masahide Asano; Yoichiro Iwakura; Masao Ichinose; Kazumasa Miki; Kiyoshi Furukawa

  Acta Histochemica et Cytochemica, 2000, Peer-reviewed

  
• Normal levels of serum glycoproteins maintained in β-1,4- galactosyltransferase I-knockout mice

  Masahiro Kido; Masahide Asano; Yoichiro Iwakura; Masao Ichinose; Kazumasa Miki; Kiyoshi Furukawa

  FEBS Letters, 24 Dec. 1999, Peer-reviewed

  
• Impaired galactosylation of core 2 O-glycans in erythrocytes of β1,4-galactosyltransferase knockout mice

  Norihiro Kotani; Masahide Asano; Yoichiro Iwakura; Seiichi Takasaki

  Biochemical and Biophysical Research Communications, 24 Jun. 1999, Peer-reviewed

  
• The human T cell leukemia virus type I-tax gene is responsible for the development of both inflammatory polyarthropathy resembling rheumatoid arthritis and noninflammatory ankylotic arthropathy in transgenic mice

  Habu K; Nakayama-Yamada J; Asano M; Saijo S; Itagaki K; Horai R; Yamamoto H; Sekiguchi T; Nosaka T; Hatanaka M; Iwakura Y

  JOURNAL OF IMMUNOLOGY, 01 Mar. 1999, Peer-reviewed

  
• Caspase 1-independent IL-1β release and inflammation induced by the apoptosis inducer Fas ligand

  Keiko Miwa; Masahide Asano; Reiko Horai; Yoichiro Iwakura; Shigekazu Nagata; Takashi Suda

  Nature Medicine, Nov. 1998, Peer-reviewed

  
• Production of mice deficient in genes for interleukin (IL)-1 alpha, IL-1 beta, IL-1 alpha/beta, and IL-1 receptor antagonist shows that IL-1 beta is crucial in turpentine-induced fever development and glucocorticoid secretion

  R Horai; M Asano; K Sudo; H Kanuka; M Suzuki; M Nishihara; M Takahashi; Y Iwakura

  JOURNAL OF EXPERIMENTAL MEDICINE, May 1998, Peer-reviewed

  
• Presence of polysialic acid and HNK-1 carbohydrate on brain glycoproteins from β-1,4-Galactosyltransferase-knockout mice

  Masahiro Kido; Masahide Asano; Yoichiro Iwakura; Masao Ichinose; Kazumasa Miki; Kiyoshi Furukawa

  Biochemical and Biophysical Research Communications, 28 Apr. 1998, Peer-reviewed

  
• Growth retardation and early death of β-1,4-galactosyltransferase knockout mice with augmented proliferation and abnormal differentiation of epithelial cells

  Masahide Asano; Kiyoshi Furukawa; Masahiro Kido; Satoshi Matsumoto; Yoshinori Umesaki; Naohisa Kochibe; Yoichiro Iwakura

  EMBO Journal, 15 Apr. 1997, Peer-reviewed

  
• Autoimmunity induction by human T cell leukemia virus type 1 in transgenic mice that develop chronic inflammatory arthropathy resembling rheumatoid arthritis in humans

  Y. Iwakura; S. Saijo; Y. Kioka; J. Nakayama-Yamada; K. Itagaki; M. Tosu; M. Asano; Y. Kanai; K. Kakimoto

  Journal of Immunology, 1995, Peer-reviewed

  
• Augmentation of c-fos and c-jun expression in transgenic mice carrying the human T-cell leukemia virus type-I tax gene

  Yoichiro Iwakura; Mariko Tosu; Emi Yoshida; Shinobu Saijo; Junko Nakayama-Yamada; Keiko Itagaki; Masahide Asano; Haruhiko Siomi; Masakazu Hatanaka; Toshio Takeda; Tetsuo Nunoya; Susumu Ueda; Hiroshi Shibuta

  Virus Genes, Jan. 1995, Peer-reviewed

  
• Transgenic mice carrying interferon genes

  Yoichiro Iwakura; Masahito Hayashi; Masahide Asano

  Molecular Reproduction and Development, 1993, Peer-reviewed

  
• Constitutive and inducible factors bind to regulatory element 3 in the promoter of the gene encoding mouse granulocyte colony-stimulating factor

  Asano Masahide; Nagata Shigekazu

  Gene, 16 Nov. 1992, Peer-reviewed

  
• Induction of interferon-α by interferon-β, but not of interferon-β by interferon-α, in the mouse

  Masahide Asano; Masahito Hayashi; Emi Yoshida; Yoshimi Kawade; Yoichiro Iwakura

  Virology, 1990, Peer-reviewed

  
• Formation of monodisperse poly(1-methacryloxybenzotriazole) particles by radiation-induced dispersion polymerization

  M. Yoshida; T. Yokota; M. Asano; M. Kumakura

  Colloid & Polymer Science, Nov. 1989, Peer-reviewed

  
• MALE-STERILITY OF TRANSGENIC MICE CARRYING EXOGENOUS MOUSE INTERFERON-BETA-GENE UNDER THE CONTROL OF THE METALLOTHIONEIN ENHANCER PROMOTER

  Y IWAKURA; M ASANO; Y NISHIMUNE; Y KAWADE

  EMBO JOURNAL, Dec. 1988, Peer-reviewed

  
• Interferon Production Under the Control of Heterologous Inducible Enhancers and Promoters

  Masahide Asano; Hitoshi Nagashima; Yoichiro Iwakura; Masahide Asano; Hitoshi Nagashima; Yoshimi Kawade

  Microbiology and Immunology, 1988, Peer-reviewed

  
• SV40 vector with early gene replacement efficient in transducing exogenous DNA into mammalian cells

  Masahide Asano; Yoichiro Iwakura; Yoshimi Kawade

  Nucleic Acids Research, 09 Dec. 1985, Peer-reviewed

  
• Pleiotropic phenotypic expression in cybrids derived from mouse teratocarcinoma cells fused with rat myoblast cytoplasts

  Yoichiro Iwakura; Masami Nozaki; Masahide Asano; Michihiro C. Yoshida; Yutaka Tsukada; Nozomu Hibi; Atsushi Ochiai; Eiichi Tahara; Mariko Tosu; Toyozo Sekiguchi

  Cell, 1985, Peer-reviewed

  
• Cloning of phosphoenolpyruvate carboxylase gene from a cyanobacterium, Anacystis nidulans, in Escherichia coli

  Tsutomu Kodaki; Fumiaki Katagiri; Masahide Asano; Katsura Izui; Hirohiko Katsuki

  Journal of Biochemistry, 1985, Peer-reviewed

  

Misc.

• HNK-1糖鎖抗原の生合成に関与するグルクロン酸転移酵素GlcAT-P遺伝子欠損マウスの作成とその解析

  岡昌吾; 山本昌司; 井上満博; 志牟田美佐; 真鍋俊也; 浅野雅秀; 岩倉洋一郎; 川崎敏祐

  日本神経科学大会プログラム・抄録集, 2002

  
• LPSによる薬物トランスポーターダウンレギュレーションにおけるサイトカインの役割解明

  芦野 隆; 渡辺 紫織; 塩田 清二; 宝来 玲子; 浅野 雅秀; 関川 賢二; 岩倉 洋一郎; 沼澤 聡; 吉田 武美

  日本薬学会年会要旨集, Mar. 2004

  
• 炎症モデルマウスによるABCトランスポーター遺伝子発現変動の検討

  芦野 隆; 内藤 弓子; 塩田 清二; 宝来 玲子; 浅野 雅秀; 岩倉 洋一郎; 吉田 武美

  日本薬学会年会要旨集, Mar. 2003

  
• BCGによるCYP3A11ダウンレギュレーションにおけるサイトカインの役割解明

  芦野 隆; 剣持 幸代; 小黒 多希子; 塩田 清二; 宝来 玲子; 浅野 雅秀; 岩倉 洋一郎; 吉田 武美

  日本薬学会年会要旨集, Mar. 2001

  
• マイクロダイアリシス法を用いたOCTN2トランスポーターの血液脳関門における機能発現評価

  稲野 彰洋; 崔 吉道; 二階堂 浩子; 橋本 憲佳; 浅野 雅秀; 玉井 郁巳; 辻 彰

  薬物動態 = Xenobiotic metabolism and disposition, 17 Sep. 2001

  
• Development of rheumatoid-like chronic inflammatory arthropathy in HTLV-1 transgenic mice is suppressed by the deficiency of IL-1 or IL-6, but not IFN-G, IL-4, nor TNF-alpha

  Y Iwakura; K Habu; M Kotani; R Horai; M Asano; Y Tagawa; C Ishitsuka; S Saijo

  EUROPEAN CYTOKINE NETWORK, Sep. 1998

  
• CONSTRUCTION OF TRANSGENIC MOUSE CARRYING EXTRA INTERFERON GENE

  M ASANO; Y IWAKURA; Y KAWADE

  ACTA MICROBIOLOGICA HUNGARICA, 1988

  
• MALE TRANSGENIC MICE CARRYING EXTRA INTERFERON GENE ARE UNABLE TO TRANSMIT THE EXOGENOUS GENE TO THEIR OFFSPRINGS

  Y IWAKURA; M ASANO; Y KAWADE

  JOURNAL OF INTERFERON RESEARCH, Dec. 1987

  
• サイトカインノックアウトマウスにおけるP450誘導の検討

  片山 周也; 芦野 隆; 丸茂 愛佳; 塩田 清二; 宝来 玲子; 浅野 雅秀; 岩倉 洋一郎; 吉田 武美

  薬物動態 = Xenobiotic metabolism and disposition, 17 Sep. 2001

  
• β-1, 4-ガラクトース転移酵素遺伝子欠損マウスの糖タンパク質糖鎖の解析

  城戸 正開; 浅野 雅秀; 岩倉 洋一郎; 巨智部 直久; 古川 清

  日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

  
• HTLV-Iトランスジェニックマウスを用いた慢性関節炎発症機構の解析

  西城 忍; 板垣 経子; 小谷 素子; 田川 陽一; 浅野 雅秀; 岩倉 洋一郎

  日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

  
• β-1, 4-ガラクトース転移酵素遺伝子ノックアウトマウスの解析

  浅野 雅秀; 松本 敏; 梅崎 良則; 城戸 正開; 古川 清; 岩倉 洋一郎

  日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

  
• Advanced glycation endproducts and RAGE have a central role in the development of diabetic vascular complications

  Y Yamamoto; T Doi; Kato, I; S Sakurai; H Yonekura; T Watanabe; KM Myint; S Takasawa; H Okamoto; M Asano; H Shinohara; H Yamamoto

  ATHEROSCLEROSIS SUPPLEMENTS, Sep. 2003

  
• Brown adipose tissue in meltrin alpha deficient mice

  KURISAKI Tomohiro; MASUDA Aki; SUDO Katsuko; SAKAGAMI Junko; ASANO Masahide; IWAKURA Yoichiro; SEHARA (FUJISAWA) Atsuko

  Keio journal of medicine, 01 Oct. 2001

  
• CHANGES OF DRUG TRANSPORTER GENE EXPRESSION BY LIPOPOLYSACCHARIDE IN VARIOUS CYTOKINES AND iNOS DEFICIENT MOUSE LIVER

  Ashino Takashi; Shioda Seiji; Horai Reiko; Asano Masahide; Sekikawa Kenji; Iwakura Yoichiro; Shimokawa Hiroaki; Numazawa Satoshi; Yoshida Takemi

  Abstracts of JSSX meeting, 2004

  
• HOT PRESS チロシン脱リン酸化酵素δのノックアウトマウスは物覚えが悪い!?

  上谷 則子; 浅野 雅秀; 岩倉 洋一郎

  細胞工学, Oct. 2000

  
• P6-08 Possible role of inflammatory cytokine in liver injury caused by cocaine(LIVER AND DIGESTIVE SYSTEM/CIRCULATORY SYSTEM-1/DEVELOPMENT AND REPRODUCTION)(GENERAL SESSION BY POSTER PRESENTATION)(Proceedings of the 31st Annual Meeting)

  NAITO Yumiko; SUGIUCHI Jinko; ASHINO Takashi; SHIODA Seiji; HORAI Reiko; ASANO Masahide; SEKIKAWA Kenji; IWAKURA Yoichiro; NUMAZAWA Satoshi; YOSHIDA Takemi

  Journal of toxicological sciences, 29 Oct. 2004

  
• Possible role of inflammatory cytokines in liver injury caused by cocaine (LIVER/DIGESTIVE SYSTEM) (GENERAL SESSION BY POSTER PRESENTATION) (Proceedings of the 30th Annual Meeting)

  SUGIUCHI JINKO; KENMOTSU SACHIYO; ASHINO TAKASHI; SHIODA SEIJI; HORAI REIKO; ASANO MASAHIDE; IWAKURA YOICHIRO; NUMAZAWA SATOSHI; YOSHIDA TAKEMI

  Journal of toxicological sciences, 31 Oct. 2003

  
• O11-04 A role of inflammatory cytokine in CYP down-regulation caused by BCG or LPS

  ASHINO Takashi; OGURO Takiko; SHIODA Seiii; HORAI Reiko; ASANO Masahide; IWAKURA Yoichiro; YOSHIDA Takemi

  Journal of toxicological sciences, 17 Oct. 2001

  
• O-24 HEME OXYGENASE GENE EXPRESSION BY LIPOPOLYSACCHARIDE IN IL-1 ALPHA/BETA KNOCK OUT MOUSE.(Proceedings of the 27th Annual Meeting)

  OGURO Takiko; TAKAHASHI Yuko; TAKAKI Atsuhi; SHIODA Seiji; HORAI Reiko; ASANO Masahide; IWAKURA Yoichiro; YOSHIDA Takemi

  Journal of toxicological sciences, 31 Oct. 2000

  
• 22C-11-1 Allergic Contact Dermatitis in IL-1 α/β Doubly Deficient Mice.

  KANAZAWA Yukiko; OGURO Takiko; HATAO Masato; SHIODA Seiji; HORAI Reiko; ASANO Masahide; IWAKURA Yoichiro; KOJIMA Koichi; YOSHIDA Takemi

  Journal of toxicological sciences, 26 Oct. 1999

  
• What is the mission of Advanced Science Research Center?

  ASANO Masahide

  金沢大学十全医学会雑誌 = Journal of the J◆U00FB◆zen Medical Society, 01 Mar. 2008

  
• Galactose-containing carbohydrates in the inflammation, development and nervous system

  Masahide Asano

  Seikagaku, 2014

  
• Sphingosine-1-phosphate receptor-2 plays a protective role against anaphylactic shock through inhibiting eNOS

  Cui Hong; Okamoto Yasuo; Yoshioka Kazuaki; Du Wa; Takuwa Noriko; Zhang Wei; Biswas Kuntal; Aki Sho; Zhao JuanJuan; Kuda Yuichi; Asano Masahide; Shibamoto Toshishige; Takuwa Yoh

  JOURNAL OF PHYSIOLOGICAL SCIENCES, 2013, Peer-reviewed

  
• Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome (vol 106, pg 468, 2008)

  Chi-Bun Chan; Michiyo Abe; Noriyoshi Hashimoto; Chunhai Hao; Ifor R. Williams; Xia Liu; Shinji Nakao; Akitsugu Yamamoto; Chengyun Zheng; Jan-Inge Henter; Marie Meeths; Magnus Nordenskjold; Shi-Yong Li; Ikuko Hara-Nishimura; Masahide Asano; Keqiang Ye

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Apr. 2009

  
• Learning/memory impairment and reduced expression of the HNK-1 carbohydrate in beta-1,4-Galactosyltransferase-II-deficient mice

  Toru Yoshihara; Kazushi Sugihara; Yasuhiko Kiduka; Shogo Oka; Masahide Asano

  NEUROSCIENCE RESEARCH, 2009

  
• Reduced ß cell proliferation and impaired glucose tolerance in pancreatic ß cell specific Extl3 knockout mice.

  Takahashi, I; Nata, K; Noguchi, N; Ikeda, T; Sugihara, K; Asano, M; Yoshikawa, T; Yamauchi, A; Shervani, N. J; Uruno, A; Unno, M; Takasawa, S; Okamoto, H; Sugawara, A

  Diabetologia, 2008

  
• Aberrant glycosylation of IgA and IgA nephropathy

  Masahide Asano; Toshikazu Nishie

  SEIKAGAKU, Jul. 2007

  
• Embryonic lethality and impaired beta cell replication by disruption of Reg receptor gene.

  Takasawa, S; Nata, K; Takahashi, I; Ikeda, T; Noguchi, N; Asano, M; Sugihara, K; Yamauchi, A; Yoshikawa, T; Shervani, N.J; Uruno, A; Unno, M; Sugawara, A; Okamoto, H

  Diabetologia, 2007

  
• Impaired beta-cell replication in heterozygous mutant mice of Reg receptor gene.

  Takasawa, S; Nata, K; Takahashi, I; Ikeda, T; Noguchi, N; Yamauchi, A; Yoshikawa, T; Shervani, N.J; Sugihara, K; Asano, M; Unno, M; Sugawara, A; Okamoto, H

  Diabetes, 2007

  
• 小脳初代培養系を用いた足場タンパク質JSAP1の解析

  佐藤時春; 岩永飛鳥; 寅嶋崇; 杉原一司; 平井宏和; 浅野雅秀; 善岡克次

  日本分子生物学会年会講演要旨集, 25 Nov. 2005

  
• Possible role of inflammatory cytokines in liver injury caused by cocaine

  T Ashino; J Sugiuchi; S Shioda; R Horai; M Asano; K Sekikawa; Y Iwakura; S Numazawa; T Yoshida

  TOXICOLOGY AND APPLIED PHARMACOLOGY, Jun. 2004

  
• Interleukin-1遺伝子欠損マウスにおける中大脳動脈閉塞後の酸化神経障害の抑制(Suppression of oxidative neuronal damage after middle cerebral artery occlusion in mice lacking interleukin-1 (IL-1))

  尹 麗; 大滝 博和; 高木 厚司; 織田 美和; 宝来 玲子; 浅野 雅秀; 岩倉 洋一郎; 塩田 洋二

  解剖学雑誌, Mar. 2002

  
• Suppression of oxidative neuronal damage after middle cerebral artery occlusion in mice lacking interleukin-1 (IL-1).

  Yin Li; Ohtaki Hirokazu; Takaki Atsushi; Oda Miwa; Horai Reiko; Asano Masahide; Iwakura Yoichiro; Shioda Seiji

  Abstracts of the Annual Meeting of the Japanese Association of Anatomists, 2002

  
• CYPダウンレギュレーションとサイトカインの役割解明

  芦野 隆; 小黒 多希子; 塩田 清二; 宝来 玲子; 浅野 雅秀; 岩倉 洋一郎; 吉田 武美

  薬物動態 = Xenobiotic metabolism and disposition, 17 Sep. 2001

  
• Importance of IL-1 and TNF-a in physiological bone remodeling.

  H Yasuda; Y Lee; S Nakae; R Horai; K Sekikawa; M Asano; Y Iwakura

  JOURNAL OF BONE AND MINERAL RESEARCH, Sep. 2001

  
• Establishment of sensitization in tumor necrosis factor deficient mouse which lacked epidermal Langerhans cells

  S Katayama; T Oguro; M Hatao; Y Kanazawa; S Shioda; R Horai; M Asano; K Sekikawa; Y Iwakura; T Yoshida

  TOXICOLOGY, Jul. 2001

  
• IL-1 alpha but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity

  S Nakae; C Naruse-Nakajima; K Sudo; R Horai; M Asano; Y Iwakura

  JOURNAL OF LEUKOCYTE BIOLOGY, 2001

  
• Functional relevance of carnitine transporter OCTN2 to brain distribution of L-camitine and acetyl-L-carnitine across the blood-brain barrier

  Yasuto Kido; Ikumi Tamai; Aki Ohnari; Yoshimichi Sai; Toru Kagami; Jun-Ichi Nezu; Hiroko Nikaido; Noriyoshi Hashimoto; Masahide Asano; Akira Tsuji

  Journal of Neurochemistry, 2001

  
• Heme oxygenase gene expression by lipopolysaccharide in IL-1 alpha/beta knock out mouse.

  T Oguro; Y Takahashi; S Shioda; R Horai; M Asano; Y Iwakura; T Yoshida

  FASEB JOURNAL, May 2000

  
• 1 サイトカインと自己免疫疾患(1 自己免疫疾患の病態と治療をめぐる最近の進歩)

  岩倉 洋一郎; 宝来 玲子; 中江 進; 浅野 雅秀; 西城 忍

  アレルギー, 2000

  
• Growth retardation and behavioral abnormalities in MPTPδ K. O. mice

  UETANI Noriko; ASANO Masahide; KAWANO Kano; OGURA Hiro; MIKOSHIBA Katsuhiko; MIZUNO Kazuya; YAKURA Hidetaka; IWAKURA Youichiro

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Generation and analysis of meltrin α deficient mice

  KURISAKI Tomohiro; SUDO Katsuko; SAKAGAMI Junko; ASANO Masahide; IWAKURA Yoichiro; SEHARA-FUJISAWA Atsuko

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• The effects of interleukin-1 on the central nervous system

  SAKATANI Tomoya; ASANO Masahide; HOURAI Reiko; SUDO Katsuko; IWAKURA Yoichiro

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Analysis of EphA2 receptor tyrosine kinase disrupted mice by gene trap retroviral insertion

  NARUSE-NAKAJIMA Chie; ASANO Masahide; IWAKURA Yoichiro

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Development of rheumatoid-like arthropathy in mice deficient in the IL-1ra gene

  HORAI Reiko; NAKAE Susumu; TANIOKA Hidetoshi; OKAHARA Akihiko; SAIJO Shinobu; SUDO Katsuko; IKUSE Toshimi; ASANO Masahide; IWAKURA Yoichiro

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Functional analysis of Caspase-8 with Caspase-8-deficient mouse

  SAKAMAKI Kazuhiro; ASANO Masahide; SAKATA Shin-ichi; TOYOKUNI Shinya; IWAKURA Yoichiro; YONEHARA Shin

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Studies on olfactory receptor gene expression using transgenic and knock-in mice

  SERIZAWA Shou; ISHII Tomohiro; NAKTANI Hiroko; ASANO Masahide; SENGOKU Shintarou; YOSHIHARA Seiichi; SAKANO Hitomi; TSUBOI Akio; NAGAWA Fumikiyo; SUZUKI Misao; IWAKURA Youichirou; SAKANO Hitoshi

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Lethality of β-1, 4-galactosyltransferase KO mice is dependent on mouse genetic background

  ASANO Masahide; SHIBATA Shinwa; IWAKURA Yoichiro

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Roles of IL-1 and IL-1 receptor antagonist in the immune system

  R Horai; M Asano; S Nakae; S Saijo; K Sudo; Y Iwakura

  EUROPEAN CYTOKINE NETWORK, Sep. 1998

  

Books and Other Publications

• ガラクトース糖鎖と炎症，発生，神経

  浅野雅秀

  生化学86: 382-390, Jun. 2014, Not refereed

  
• Asparaginyl endopeptidase欠損マウスにおける血球貪食症候群様病態について

  浅野雅秀; 橋本憲佳

  血液内科63: 634-639, Dec. 2011, Not refereed

  
• 疾患モデルの作製と利用—免疫疾患（seriesモデル動物利用マニュアル）

  浅野雅秀, Contributor, 第５節第２項 糖鎖リガンド（523-529）

  エル・アイ・シー, Jun. 2011, Not refereed

  
• 生物機能モデルと新しいリソース・リサーチツール（seriesモデル動物利用マニュアル）

  浅野雅秀, Contributor, 第８節 ガラクトース転移酵素（346-353）

  エル・アイ・シー, Feb. 2011, Not refereed

  
• 第３の生命鎖：糖鎖の謎が今，解る

  浅野雅秀, IgA腎症の発症には糖鎖がからんでいる（123-130）

  クバプロ, Feb. 2009, Not refereed

  
• 総説「免疫グロブリンAの糖鎖不全と腎臓疾患」

  浅野雅秀

  蛋白質核酸酵素53: 1611-1616, Sep. 2008, Not refereed

  
• ミニレビュー「IgAの糖鎖不全とIgA腎症」

  浅野雅秀; 西江敏和

  生化学79: 673-678, Jul. 2007, Not refereed

  
• 未来を拓く糖鎖科学

  浅野雅秀, Contributor, β-1,4-ガラクトース転移酵素I(β4GalT-I)遺伝子ノックアウトマウスによる糖鎖機能の解明

  金芳堂, Dec. 2005, Not refereed

  
• 糖鎖と病気

  西江敏和; 浅野雅秀, IgA腎症と糖鎖不全IgA

  遺伝子医学MOOK 3: 53-58, Sep. 2005, Not refereed

  
• Annual Review 2005腎臓

  浅野雅秀; 西江敏和, 糖転移酵素遺伝子破壊による新たなIgA腎症モデル

  中外医学社57-61, Jan. 2005, Not refereed

  
• 糖鎖とIgA腎症

  浅野雅秀; 西江敏和; 宮石理

  Molecular Medicine40: 1056-1061, Aug. 2003, Not refereed

  
• 遺伝子トラップ法

  成瀬智恵; 浅野雅秀

  発生工学81: 351-354, Aug. 2003, Not refereed

  
• 改訂第２版分子生物学イラストレイテッド

  浅野 雅秀, Contributor, ５章分子生物学的方法論，個体を用いる方法

  羊土社, Oct. 2002, Not refereed

  
• チロシン脱リン酸化酵素δのノックアウトマウスは物覚えが悪い

  上谷則子; 浅野雅秀; 岩倉洋一郎

  細胞工学1498-1500, Oct. 2000, Not refereed

  
• 細菌誘導性劇症肝炎モデルにおけるIL-1の役割

  浅野雅秀

  医学のあゆみ（別冊）117-120, Jul. 2000, Not refereed

  
• 遺伝子改変動物研究のめざすもの

  浅野雅秀

  モダンメディア44: 85-90, Mar. 1999, Not refereed

  

Industrial Property Rights

• グリコサミノグリカン糖鎖の生合成不全マウス

  
• ORC4遺伝子変異非ヒト動物

  
• VPE欠損モデル

  
• 脳高次機能障害を有する非ヒト動物及びその製造方法

  
• 好中球走化性因子LECT2遺伝子の機能が欠損したマウス

  
• インターロイキン-1関連疾患モデルノックアウト動物

  
• ＧＮＥ遺伝子に変異を有するトランスジェニック非ヒト哺乳動物

  
• IgA腎症の治療薬のスクリーニング

  

Works

• β4-ガラクトース転移酵素-I KOマウスにおけるIgA腎症発症機構の解析

  From 2005

  
• 超純水製造装置からの水に対する成分評価

  From 2005

  
• Analysis of IgA nephropathy development in b4-galactosyltransferase KO mice

  From 2005

  
• Quality of water produced by super pure water maker

  From 2005

  

Awards

• 16 May 2019

  Japanese Association for Laboratory Animal Science, Ando-Tajima Award

External funds: Kakenhi

• 時期および組織特異的なプロテインノックダウンを可能とするデグロンシステムの開発

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 42:Veterinary medical science, animal science, and related fields

  Kyoto University

  成瀬 智恵

  From 09 Jul. 2021, To 31 Mar. 2024, Granted

  デグロン;マウス;プロテインノックダウン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19188/
• Analysis of galactose carbohydrates regulating homing and differentiation of HSC in the bone marrow niche

  Grant-in-Aid for Scientific Research (B)

  Basic Section 42040:Laboratory animal science-related

  Kyoto University

  浅野 雅秀

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  ガラクトース糖鎖;造血幹細胞;ホーミング;血液細胞分化;骨髄ニッチ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02389/
• Development of degron system for cancer therapy

  Grant-in-Aid for Scientific Research (B)

  Basic Section 42040:Laboratory animal science-related

  Kyoto University

  成瀬 智恵

  From 01 Apr. 2020, To 31 Mar. 2024, Granted

  デグロン;マウス;プロテインノックダウン;PD-1

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03171/
• Establishment of new ADHD model mice based on ganglioside deficiency

  Grant-in-Aid for Scientific Research (C)

  Basic Section 42040:Laboratory animal science-related

  Kyoto University

  Toru Yoshihara

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  行動解析;マウス;発達障害;ADHD;ガングリオシド;糖転移酵素;活動性;注意機能;運動制御;大脳皮質;運動機能;体性感覚;注意欠陥・多動性障害;疾患モデル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K06468/
• Establishment of a novel cancer therapy using degron system in mice

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 42:Veterinary medical science, animal science, and related fields

  Kyoto University

  Masahide Asano

  From 29 Jun. 2018, To 31 Mar. 2021, Project Closed

  デグロン;PD-1;マウス;がん免疫療法

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19269/
• Functions of B4galt1 in the homing of hematopoietic stem cells.

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Chie Naruse

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  造血幹細胞;ホーミング;糖鎖;マウス;B4galt1;造血幹細胞分化;β4GalT1;beta4-GalT1;GalT1;応用動物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K07135/
• Attempt to establish totipotent stem cells using degron system

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Kazushi Sugihara

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  デグロン;マウス;ゲノム編集;マウス初期胚発生;デグロンシステム;発生;初期胚;発生・分化;動物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K14594/
• Establishment of new mental disease model mouse by heterochromatin factor HP1 deficiency

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Toru Yoshihara

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  マウス;精神疾患モデル;行動解析;エピジェネティクス;モデルマウス;精神疾患;不安;うつ;情動性;活動性;行動薬理学的解析;薬理学的解析;発現アレイ解析;モデル動物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K07090/
• Study on neurological disorder caused by ganglioside-deficiency and therapeutics by glycolipid supplement

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Masahide Asano

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  ガングリオシド;LacCer合成酵素;ガラクトース転移酵素;神経細胞;軸索;ミエリン鞘;神経幹細胞;糖鎖;脳神経疾患

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H04681/
• Analysis of gut microbiota and gut immunity in the development of IgA nephropathy using its mouse model

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  MASAHIDE ASANO

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  IgA腎症;糖鎖;腸内細菌叢;腸内細菌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K14360/
• The roles of histone modifications in the perinatal period.

  Grant-in-Aid for Scientific Research (C)

  Kyoto University;Kanazawa University

  Chie Naruse

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  マウス;脱メチル化酵素;ホメオティック変異;ヒストン脱メチル化;HP1;神経幹細胞;エピジェネティクス;発生;神経;Hox遺伝子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25430085/
• Analysis of brain functions regulated by histone modification and development of psychiatric disorder animal models

  Grant-in-Aid for Scientific Research (B)

  Kyoto University;Kanazawa University

  Masahide Asano

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  エピジェネティクス;脳神経疾患;行動学;遺伝子改変マウス;脳・神経;遺伝子組換えマウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25290031/
• Identification of novel homing molecules of hematopoietic stem cells and development of efficient bone marrow transfer methods by modifying carbohydrates

  Grant-in-Aid for Challenging Exploratory Research

  Kanazawa University

  Masahide ASANO

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  糖鎖;骨髄幹細胞;骨髄移植;ホーミング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23650232/
• The development and demonstration of methodology to elucidate the sugar chain function and glycosyltransferase knockout mouse phenotype.

  Grant-in-Aid for Scientific Research (C)

  Kanazawa University

  Kazushi SUGIHARA

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  発生工学;遺伝子改変動物;糖鎖生物学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23500493/
• 生殖細胞の発生・分化においてヒストン修飾因子が果たす制御機構の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kanazawa University

  浅野 雅秀

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  発生・分化;生殖細胞;始原生殖細胞;ヒストン修飾;遺伝子改変動物

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-23013012/
• The role of carbohydrates including galactose and sialic acids in higher brain functions

  Grant-in-Aid for Scientific Research (B)

  Kanazawa University

  Masahide ASANO

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  糖鎖;糖転移酵素;高次脳機能;行動実験;遺伝子改変動物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22300142/
• Characterization of AEP/Legumain-deficient mice as a new model of lysosome disease

  Grant-in-Aid for Scientific Research (C)

  Kanazawa University

  Noriyoshi HASHIMOTO

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  血球貪食症候群;リソソーム病;ゴーシェ細胞;遺伝子改変動物;病態モデル;マクロファージ;赤血球;血液疾患

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21500387/
• 始原生殖細胞の初期分化におけるHP1γとヒストン修飾の機能解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kanazawa University

  浅野 雅秀

  From 01 Apr. 2009, To 31 Mar. 2011, Project Closed

  発生・分化;生殖細胞;始原生殖細胞;ヒストン修飾;遺伝子改変動物;始源生殖細胞;エピジェネティクス;細胞周期

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-21028007/
• Genesis and physiologic significance of secretory RAGE-a new vasoprotective factor

  Grant-in-Aid for Scientific Research (B)

  Kanazawa University

  Hiroshi YAMAMOTO

  From 01 Apr. 2007, To 31 Mar. 2011, Project Closed

  RAGE;分泌型バリアント;RNAスプライシング;遺伝子改変動物;アルツハイマー病;LPS誘発ショック;アポトーシス;esRAGE;alternative splicing;糖尿病合併症;デコイ受容体;ノックインマウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390085/
• Development of mouse models for human diseases caused by impaired glycosylation and analysis of their mechanisms

  Grant-in-Aid for Scientific Research (B)

  Kanazawa University

  Masahide ASANO

  From 01 Apr. 2007, To 31 Mar. 2010, Project Closed

  IgA腎症;ネフローゼ;糖鎖;ガラクトース転移酵素;シアル酸生合成;行動解析;骨随移植;ミオパチー;記憶・学習

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19300144/
• Characterization of AEP/Legumain-deficient mice as a model of hemophagocytic syndrome-like disease

  Grant-in-Aid for Scientific Research (C)

  Kanazawa University

  Noriyoshi HASHIMOTO

  From 01 Apr. 2006, To 31 Mar. 2009, Project Closed

  病態モデル;血球貪食症候群;Legumain;AEP;リソソーム蓄積症;プロテアーゼ;リソソーム病;遺伝子改変動物;血液疾患;疾患モデルマウス;レグマイン;実験動物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18500325/
• 生殖細胞のインプリンティングおよび減数分裂におけるHP1γの機能解明

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kanazawa University

  浅野 雅秀

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  生殖細胞;エピジェネティックス;インプリンティング;遺伝子改変マウス;不妊

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18051008/
• β4-ガラクトース転移酵素-I欠損によるIga腎症発症機構の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kanazawa University

  浅野 雅秀

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  IgA腎症;ガラクトース転移酵素;高IgA血症;遺伝子ノックアウトマウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17046005/
• Development of a fundamental technology, which is applicable to drug development and therapeutic applications through analysis of sulfated glycosaminoglycan chains

  Grant-in-Aid for Scientific Research (B)

  KOBE PHARMACEUTICAL UNIVERSITY

  Kazuyuki SUGAHARA

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  コンドロイチン硫酸;デルマタン硫酸;硫酸基転位酵素;先天性脊髄・骨端異形成症;コンドロイチン重合化因子;RNA Interference;神経突起伸長;プレイオトロフィン;硫酸基転移酵素;RNA;先天性脊椎・骨端異形成症;RANi;プライオトロフィン, chondroitin sulfate;dermatan sulfate;sulfotransferase;spondyloepiphysial dysplasia;chondroitin polymerizing factor;RNA intereference;neurite outgrowth;pleiotrpohin

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390026/
• 自己免疫疾患におけるアスパラギンエンドペプチダーゼによる免疫記憶の調節

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kanazawa University

  浅野 雅秀

  From 01 Apr. 2004, To 31 Mar. 2005, Project Closed

  アスパラギンエンドペプチダーゼ;抗原プロセッシング;抗原提示;実験的自己免疫性脳脊髄炎;ミエリン塩基性タンパク質;脾臓肥大

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16043221/
• ORC4変異マウスを用いた個体レベルでの細胞周期研究

  Grant-in-Aid for Exploratory Research

  Kanazawa University

  浅野 雅秀

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  複製開始点認識複合体;Orc4;トランスジェニックマウス;胚性幹細胞;DNA複製;細胞周期;遺伝子トラップ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15657045/
• Functional analysis of carbohydrate antigens in chemically induced tumor cells derived from beta-1,4-galactosyltransferase-I knockout mice

  Grant-in-Aid for Scientific Research (C)

  Kanazawa University

  Noriyoshi HASHIMOTO

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  糖転移酵素遺伝子;糖鎖抗原;癌特異抗原;基幹糖鎖構造;ガラクトース;ノックアウトマウス;化学発癌, Carbohydrate;Knockout mice;Galactosyltransferase;Tumor antigen;Galactose;Chemical carcinogen;Skin tumor;Malignancy

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15500298/
• 改良遺伝子トラップ法による新規発生制御遺伝子の単離と機能解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kanazawa University

  浅野 雅秀

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  遺伝子トラップ;発生制御転写因子;アデノウイルスベクター;初期発生;原腸陥入;中胚葉誘導

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14034218/
• Elucidation of individual roles of the galactosyl|ransferase gene family using gene knockout mice

  Grant-in-Aid for Scientific Research (B)

  Kanazawa University

  Masahide ASANO

  From 01 Apr. 2001, To 31 Mar. 2004, Project Closed

  糖鎖;ノックアウトマウス;ガラクトース転移酵素;セレクチン;炎症反応;皮膚創傷治癒;胎生致死;糖転移酵素遺伝子;ガラクトース糖鎖;遅延型過敏症;コンジェニックマウス, Carbohydrate;Knockout mice;Galactosyltransferase;Selectins;Inflammation;Skin wound healing;Embryonic lethal

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13480280/
• Analysis of the biosynthetic mechanism and functions of glycosaminogycans by manipulating the genes encoding biosynthetic enzymes.

  Grant-in-Aid for Scientific Research (B)

  Kobe Pharmaceutical University

  Kazuyuki SUGAHARA

  From 01 Apr. 2001, To 31 Mar. 2004, Project Closed

  グリコサミノグリカン;ヘパラン硫酸;コンドロイチン硫酸;糖転移酵素;硫酸基転移酵素;コンドロイチン合成酵素;コンドロイチン重合因子;RNAi;ガン抑制遺伝子;EXT;プロテオグリカン;線虫;糖転位酵素;グルクロン酸転位酵素;ショウジョウバエ;シンデカン;グルクロン酸転移酵素;N-アセチルガラクトサミン転移酵素, glycosaminoglycan;heparan sulfate;chondroitin sulfate;glycosyltransferase;sulfotransferase;chondroitin synthase;chondroitin polymerizing factor;RNAi

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13470493/
• 糖転移酵素遺伝子欠損マウスを用いた発癌・転移における糖鎖機能の解析

  Grant-in-Aid for Scientific Research on Priority Areas (C)

  Biological Sciences

  Kanazawa University

  浅野 雅秀

  From 01 Apr. 2001, To 31 Mar. 2002, Project Closed

  糖転移酵素遺伝子;腫瘍糖鎖抗原;基幹糖鎖構造;ルイス抗原;浸潤・転移

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13216038/
• 改良遺伝子トラップ法による新規発生制御遺伝子の単離と機能解析

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Biological Sciences

  Kanazawa University

  浅野 雅秀

  From 01 Apr. 2001, To 31 Mar. 2002, Project Closed

  遺伝子トラップ;発生制御転写因子;原腸陥入;中胚葉誘導;アデノウイルスベクター

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13045014/
• 糖転移酵素遺伝子欠損マウスを用いた発癌・転移における糖鎖機能の解析

  Grant-in-Aid for Scientific Research on Priority Areas (C)

  Biological Sciences

  Kanazawa University

  浅野 雅秀

  From 01 Apr. 2000, To 31 Mar. 2001, Project Closed

  糖転移酵素遺伝子;腫瘍抗原;シアリルLe^x;メチルコラントレン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12215036/
• ガラクトース転移酵素遺伝子ノックアウトマウスを用いた糖鎖機能の解析

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kanazawa University

  浅野 雅秀

  From 01 Apr. 2000, To 31 Mar. 2001, Project Closed

  ガラクトース転移酵素;ノックアウトマウス;胎生致死;胎盤形成

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12033202/
• A trial to generate recipient mice which support the development of human hematopoietic stem cells to T-lymphocytes

  Grant-in-Aid for Scientific Research (C)

  The University of Tokyo

  Katsuko SUDO

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  ケモカイン;SDF-1;トランスジェニックマウス;血液幹細胞, transgenic mice;SDF-1;stem cell;scid mice

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11680818/
• ガラクトース転移酵素遺伝子ノックアウトマウスを用いた糖鎖機能の解析

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kanazawa University

  浅野 雅秀

  From 01 Apr. 1999, To 31 Mar. 2000, Project Closed

  ガラクトース転移酵素;ノックアウトマウス;胎生致死;セレクチン;遅延型接触過敏症反応

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11159202/
• ヒトT細胞白血病ウイルスによる自己免疫発症機構の解析

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  The University of Tokyo

  岩倉 洋一郎

  From 01 Apr. 1999, To 31 Mar. 2000, Project Closed

  HTLV-I;トランスジェニックマウス;慢性関節炎;IL-1;IL-1レセプターアンタゴニスト;自己免疫

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11148209/
• インターフェロン・サイトカインの抗癌作用の研究

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  The University of Tokyo

  岩倉 洋一郎

  From 01 Apr. 1999, To 31 Mar. 2000, Project Closed

  発癌;インターフェロン;サイトカイン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11140218/
• Functional analysis of IL-1 in immune and stress responses using gene knockout mice

  Grant-in-Aid for Scientific Research (C)

  Kanazawa University;The University of Tokyo

  Masahide ASANO

  From 01 Apr. 1998, To 31 Mar. 2001, Project Closed

  IL-1;ノックアウトマウス;炎症反応;抗体産生;接触過敏症反応;関節リウマチ;ストレス応答;アポトーシス;T細胞フライミング;細菌誘導性肝炎;ディファレンシャル・ディスプレイ;エンドトキシンショック, IL-1;Knockout mice;Inflammation;Antibody Production;Contact Hypersensitivity;RheumatoidArthritis;Stress Response;Apoptosis

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670298/
• Development of rheumatoid arthritis models using transgenic technique

  Grant-in-Aid for Scientific Research (B).

  The University of Tokyo

  Yoichiro IWAKURA

  From 01 Apr. 1998, To 31 Mar. 2001, Project Closed

  関節リウマチ;トランスジェニックマウス;ノックアウトマウス;HTLV-I;IL-1;IL-6;自己免疫;病態モデルマウス;疾患モデル;サイトカイン;HTLV-I-Tgマウス;コンジェニック;IL-1レセプターアンタゴニスト, Rheumatoid arthritis;transgenic mice;knockout mice;HTLV-I;IL-1;IL-6;antoimmune disease;model mice

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10558120/
• 発生工学的手法によるエイズ制圧の試み

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Biological Sciences

  The University of Tokyo

  岩倉 洋一郎

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  エイズ;トランスジェニックマウス;サイトカイン;HIV;ノックアウトマウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10180205/
• ガラクトース転移酵素遺伝子ノックアウトマウスを用いた糖鎖機能の解析

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  The University of Tokyo

  浅野 雅秀

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  ノックアウトマウス;ガラクトース転移酵素;セレクチン;成長遅延

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10178201/
• ヒトT細胞白血病ウイルスによる自己免疫発症機構の解析

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  The University of Tokyo

  岩倉 洋一郎

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  HTLV-I;関節リウマチ;自己免疫疾患;サイトカイン;IL-1;IL-6;コラーゲン誘導関節炎

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10167203/
• ヒト細胞白血病ウィルスによる自己免疫症機構の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  The University of Tokyo

  岩倉 洋一郎

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  HTLV-I;関節リウマチ;自己免疫;コラーゲン誘導関節炎;サイトカイン;ノックアウトマウス;IL-1;IL-6

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09271207/
• インターフェロンによるアポトーシスの誘導と発がん抑制

  Grant-in-Aid for Scientific Research on Priority Areas

  The University of Tokyo

  岩倉 洋一郎

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  ノックアウトマウス;IFN-γ;B16メラノーマ;IFN-γレセプター

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09253211/
• サイトカイン研究のための遺伝子改変マウスライブラリーの作製

  Grant-in-Aid for Scientific Research (A)

  The University of Tokyo

  岩倉 洋一郎

  From 01 Apr. 1996, To 31 Mar. 1999, Project Closed

  トランスジェニックマウス;ノックアウトマウス;IL-1α;IL-1β;IFN-γ;IL-6;HTLV-I;関節リウマチ;IL-1レセプターアンタゴニスト;HTLV-L Tgマウス;HIV-Tgマウス;HTLV-I Tgマウス;IL-12;HTLV-I-Tgマウス;HIV-I-Tgマウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08408037/
• ヒトT細胞白血病ウイルスによる自己免疫発症機構の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  The University of Tokyo

  岩倉 洋一郎

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  HTLV-I;関節リウマチ;自己免疫;サイトカイン;ノックアウトマウス;コラーゲン誘導関節炎

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08282212/
• 標的遺伝子組み換え法によるサイトカインの炎症反応における役割の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  The University of Tokyo

  岩倉 洋一郎

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  標的遺伝子組み換え;ノックアウトマウス;サイトカイン;インターロイキン1;インターフェロンγ;エンドトキシンショック;炎症性発熱;ConA誘導肝炎

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08252203/
• 標的遺伝子組換えによるガラクトシルトランスフェラーゼ遺伝子の発生過程での機能解析

  Grant-in-Aid for Encouragement of Young Scientists (A)

  The University of Tokyo

  浅野 雅秀

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  標的遺伝子組換え;遺伝子欠損マウス;糖転移酵素;ガラクトシルトランスフェラーゼ;角化亢進症;細胞増殖;二糖類分解酵素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07780649/
• 標的遺伝子組み換え法を用いたサイトカインの生理機能の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  The University of Tokyo

  岩倉 洋一郎

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  標的遺伝子組換え;遺伝子欠損マウス;サイトカイン;インターロイキン-1;インターフェロン;エンドトキシンショック;ConA肝炎

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07260204/
• 標的組換えによるガラクトシルトランスフェラーゼ遺伝子の発生過程での機能解析

  Grant-in-Aid for Encouragement of Young Scientists (A)

  The University of Tokyo

  浅野 雅秀

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  標的遺伝子組換え;遺伝子欠損マウス;糖転移酸素;ガラクトシルトランスフェラーゼ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06780606/
• 標的遺伝子組換え法を用いたサイトカインの生理機能の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  The University of Tokyo

  岩倉 洋一郎

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  標的遺伝子組換え;遺伝子欠損マウス;サイトカイン;インターフェロン;インターロイキン-1

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06268205/
• 脆弱な大脳皮質ニューロンによる生命維持機構の障害

  Grant-in-Aid for Scientific Research (C)

  Basic Section 42040:Laboratory animal science-related

  Kyoto University

  吉原 亨

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  マウス;糖鎖;ガングリオシド;脳機能;行動解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K06054/
• ゲノム編集技術による、シリアンハムスターおよびラットにおける早期老化モデルの創出

  Grant-in-Aid for Scientific Research (C)

  Basic Section 59040:Nutrition science and health science-related

  Kyoto University

  椛嶋 克哉

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  シリアンハムスター;ラット;ゲノム編集;老化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K10935/
• 終脳特異的なガングリオシド欠損が脳発達に及ぼす影響の解析

  Grant-in-Aid for Scientific Research (C)

  Basic Section 42040:Laboratory animal science-related

  Kyoto University

  配島 旭

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  ガングリオシド;脳発達

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K09298/

External funds: others

• ラットリソースの収集・保存・提供 (2022年度分)

  文部科学省, 研究開発施設共用等促進費補助金

  From 01 Apr. 2022, To 31 Mar. 2023

  分担
• ラットリソースの収集・保存・提供 (2021年度分)

  文部科学省, 研究開発施設共用等促進費補助金

  From 01 Apr. 2021, To 31 Mar. 2022

  代表
• ラット生殖工学基盤技術開発によるリソース保存の効率化と新規利用者の拡大 (2021年度分)

  文部科学省, 医療研究開発推進事業費補助金(令和2年度繰越分)

  From 01 Apr. 2021, To 31 Mar. 2022

  代表
• ラットリソースの収集・保存・提供 （平成29年度分）

  医療研究開発推進事業費補助金

  From 01 Apr. 2017, To 31 Mar. 2018

  浅野 雅秀
• ラットリソースの収集・保存・提供 （平成30年度分）

  医療研究開発推進事業費補助金

  From 01 Apr. 2018, To 31 Mar. 2019

  浅野 雅秀
• ラットリソースの収集・保存・提供 （2019年度分）

  医療研究開発推進事業費補助金

  From 01 Apr. 2019, To 31 Mar. 2020

  浅野　雅秀
• ラット生殖工学基盤技術開発によるリソース保存の効率化と新規利用者の拡大 （2019年度分）

  医療研究開発推進事業費補助金

  From 01 Apr. 2019, To 31 Mar. 2020

  浅野 雅秀
• ラットリソースの収集・保存・提供 （2020年度分）

  医療研究開発推進事業費補助金

  From 01 Apr. 2020, To 31 Mar. 2021

  浅野　雅秀
• ラット生殖工学基盤技術開発によるリソース保存の効率化と新規利用者の拡大 （2020年度分）

  医療研究開発推進事業費補助金

  From 01 Apr. 2020, To 31 Mar. 2021

  浅野　雅秀

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Physiology

  W641, Fall, Graduate School of Engineering, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Animal Science

  8030, Spring, Faculty of Medicine, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Animal Science

  8030, Spring, Faculty of Medicine, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Physiology I

  E006, Fall, Graduate School of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physiology

  B007, Fall, Faculty of Medicine, 3.5
• From 01 Apr. 2023, To 31 Mar. 2024

  Physiology II

  E007, Fall, Graduate School of Medicine, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Animal Science

  8030, Spring, Faculty of Medicine, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Animal Science

  L060, Fall, Faculty of Medicine, 0
• From Apr. 2015, To Mar. 2016

  Laboratory Animal Science

  Fall, 医学部
• From Apr. 2015, To Mar. 2016

  Laboratory Animal Science

  Fall, 医学研究科
• From Apr. 2016, To Mar. 2017

  Laboratory Animal Science

  Fall, 医学部
• From Apr. 2016, To Mar. 2017

  Laboratory Animal Science

  Fall, 医学研究科
• From Apr. 2017, To Mar. 2018

  Laboratory Animal Science

  Fall, 医学部
• From Apr. 2018, To Mar. 2019

  Laboratory Animal Science

  Fall, 医学部
• From Apr. 2019, To Mar. 2020

  Laboratory Animal Science

  Fall, 医学部
• From Apr. 2019, To Mar. 2020

  Laboratory Animal Science

  Spring, 医学部（人間健康科学科）
• From Apr. 2020, To Mar. 2021

  Laboratory Animal Science

  Fall, 医学部
• From Apr. 2020, To Mar. 2021

  Laboratory Animal Science

  Spring, 医学部（人間健康科学科）
• From Apr. 2020, To Mar. 2021

  Physiology II

  Fall, 医学研究科
• From Apr. 2020, To Mar. 2021

  Physiology I

  Fall, 医学研究科
• From Apr. 2020, To Mar. 2021

  Physiology

  Fall, 医学研究科
• From Apr. 2021, To Mar. 2022

  Laboratory Animal Science

  Fall, 医学部
• From Apr. 2021, To Mar. 2022

  Laboratory Animal Science

  Spring, 医学部（人間健康科学科）

Participation in PhD Defense

• Versican provides the provisional matrix for uterine spiral artery dilation and fetal growth

  SAGAE YUSUKE, Graduate School of Medicine, Chief Examiner

  24 Jul. 2023
• Individual identification of inbred medaka based on characteristic melanophore spot patterns on the head

  MORIZUMI HAJIME, Graduate School of Medicine, Sub-chief Examiner

  23 May 2023
• Bioresorbable poly (L-lactic acid) flow diverter versus cobalt-chromium flow diverter: in vitro and in vivo analysis

  SASAKI NATSUHI, Graduate School of Medicine, Sub-chief Examiner

  24 Nov. 2023
• AMPK activation reverts mouse epiblast stem cells to naive state

  LIU YAJING, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Dynamic metabolic changes observed in an LPS-induced systemic inflammation rat model using continuous long-term indirect calorimetry experiments

  MURATA SATORU, Graduate School of Medicine, Sub-chief Examiner

  24 Nov. 2023
• Inhibition of VEGF receptors induces pituitary apoplexy: an experimental study in mice

  SUGITA YOSHITO, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Flavonoid Nobiletin Attenuates Cyclophosphamide-Induced Cystitis in Mice through Mechanisms That Involve Inhibition of IL-1β Induced Connexin 43 Upregulation and Gap Junction　Communication in Urothelial Cells

  KONO JIN, Graduate School of Medicine, Chief Examiner

  23 Mar. 2023
• Establishment of a radiation-induced vocal fold fibrosis mouse model

  TANIGAMI YUKI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• ARID1A loss-of-function induces CpG island methylator phenotype

  YAMADA HARUMI, Graduate School of Medicine, Sub-chief Examiner

  26 Sep. 2022
• NRSF-GNAO1 Pathway Contributes to the Regulation of Cardiac Ca2+ Homeostasis

  INAZUMI HIDEAKI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• DNA methyltransferase 3B plays a protective role against hepatocarcinogenesis caused by chronic inflammation via maintaining mitochondrial homeostasis

  IGUCHI ERIKO, Graduate School of Medicine, Sub-chief Examiner

  26 Jul. 2021
• Glucocorticoids suppress fibroblast apoptosis in an in vitro thermal injury model

  MATSUURA YOSHITAKA　, Graduate School of Medicine, Sub-chief Examiner

  24 Nov. 2021

Administration

School management (title, position)

• From 01 Apr. 2023, To 31 Mar. 2025

  動物実験施設 施設長
• From 01 Apr. 2015, To 30 Sep. 2018

  京都大学動物実験委員会 委員
• From 01 Apr. 2016, To 31 Mar. 2019

  研究倫理・安全推進委員会 委員
• From 01 Apr. 2015, To 31 Mar. 2019

  動物実験施設長
• From 01 Apr. 2015, To 31 Mar. 2021

  動物実験施設長
• From 01 Apr. 2019, To 31 Mar. 2021

  研究倫理・安全推進委員会 委員
• From 01 Oct. 2018, To 30 Sep. 2020

  京都大学動物実験委員会 委員長
• From 01 Apr. 2021, To 31 Mar. 2023

  動物実験施設　施設長
• From 01 Apr. 2021, To 31 Mar. 2023

  研究倫理・安全推進委員会 委員
• From 01 Oct. 2020, To 30 Sep. 2022

  京都大学動物実験委員会 委員長

Faculty management (title, position)

• From 01 Oct. 2022, To 30 Sep. 2024

  京都大学医学研究科・医学部動物実験委員会
• From 01 Oct. 2022, To 30 Sep. 2024

  京都大学医薬系総合研究棟管理運営委員会委員
• From 01 Apr. 2015, To 30 Sep. 2020

  動物実験委員会
• From 01 Apr. 2015, To 31 Mar. 2021

  動物実験施設管理委員会
• From 01 Apr. 2015

  医学研究支援センター運営委員会
• From 01 Apr. 2015

  バイオ・フロンティア・プラットフォーム運営委員会
• To 30 Sep. 2017

  医学研究科運営委員会
• From 01 Oct. 2016, To 30 Sep. 2020

  京都大学医薬系総合研究棟管理運営委員会
• From 01 Dec. 2016, To 30 Nov. 2020

  京都大学分子生物実験研究棟管理運営委員会
• 将来計画検討委員会
• From 01 Apr. 2019, To 31 Mar. 2021

  医学図書館運営委員会
• From 01 Nov. 2018, To 31 Oct. 2020

  教授選考方針検討委員会基礎系検討委員会
• 放射線障害防止委員会
• From 01 Oct. 2020, To 30 Sep. 2022

  動物実験委員会委員
• From 01 Oct. 2020, To 30 Sep. 2022

  医薬系総合研究棟管理委員会委員
• From 01 Oct. 2020, To 31 Mar. 2022

  病原体等安全管理委員会委員
• From 01 Dec. 2020, To 30 Nov. 2022

  京都大学分子生物実験研究棟管理運営委員会委員

Academic, Social Contribution

Committee Memberships

• From 2018, To Present

  理事, 日本実験動物学会
• From 2016, To 2017

  評議員, 日本実験動物学会
• From 2010, To 2015

  理事, 日本実験動物学会
• From 2012, To 2013

  会長, 国立大学法人動物実験施設協議会
• From 2010, To 2011

  副会長, 国立大学法人動物実験施設協議会
• From 2002, To 2007

  評議員, 日本実験動物学会
• From 2004, To 2005

  副会長, 国立大学法人動物実験施設協議会