Basic Information

Faculty

• 薬学部

Professional Memberships

• Biophysical Society
• The Japanese Peptide Society
• The Pharmaceutical Society of Japan

Academic Degree

• 薬学修士(京都大学)
• 博士（薬学）(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院薬学研究科修士課程製薬化学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 京都大学, 薬学部薬学科, 卒業

High School

• High School

  大阪府立大手前高校

Research History

• From 2008, To 2009

  京都大学 薬学研究科(研究院), 教授
• From 2004, To 2006

  京都大学 薬学研究科(研究院), 教授
• From 2003, To 2006

  京都大学 薬学研究科, 教授
• From May 2003

  Graduate School of Pharmaceutical Sciences, Kyoto University, Professor
• From 2000, To 2003

  京都大学 生命科学研究科, 助教授
• From 2000, To 2001

  京都大学 大学院・生命科学研究科, 助教授
• From 2001

  京都大学 生命科学, 助教授
• From 2001

  Kyoto University, 助教授
• From Apr. 1999

  Graduate School of Biostudies, Kyoto University, Associate professor
• From 1998

  京都大学 薬学研究科, 助教授
• From Sep. 1997

  Graduate School of Pharmaceutical Siences, Kyoto University, Associate professor
• From 1996, To 1997

  Kyoto University, Faculty of Pharmaceutical Sciences, 助手
• From 1997

  京都大学 大学院・薬学研究科, 助教授
• From 1990, To 1991

  Kyoto University, Faculty of Pharmaceutical Sciences, 助手
• From Oct. 1987

  Faculty of Pharmaceutical Sciences, Kyoto University, Assistant Professor
• From Apr. 1984

  Takeda Chemical Co., Resercher

Profile

• Profile

  I investigate dynamic molecular interactions in biomembranes.

Language of Instruction

• English

ID,URL

• J-Global ID

  200901088027665767

• External link

  http://www.pharm.kyoto-u.ac.jp/yakkai/

Website(s) (URL(s))

• http://www.pharm.kyoto-u.ac.jp/yakkai/

researchmap URL

• https://researchmap.jp/KMatsuzaki

Research

Research Topics, Overview of the research

• Research Topics

  Elucidation of dynamic interactions of proteins and peptides with lipids in membranes

Research Interests

• Physical Pharmaceutical Sciences
• Biophysical Chemistry
• 包括脳ネットワーク
• 統合脳・病態脳
• シス-トランス互変異性
• 細胞内ループ
• フリッププロップ
• ドラックデリバリー
• 脂質
• シャペロン
• 細胞膜透過
• ベクター
• 膜
• 凝集体
• 静電的相互作用
• 細胞透過ペプチド
• アミロイド線維
• 相乗効果
• 脂質膜
• ペプチド
• 超分子
• PGLa
• 膜透過
• β-シート
• コレステロール
• 膜透過性
• 細胞毒性
• マガイニン2
• ガングリオシド
• 抗菌性ペプチド
• マガイニン
• 脂質ラフト
• アルツハイマー病
• アミロイドβ蛋白

Research Areas

• Life sciences, Pharmaceuticals - chemistry and drug development
• Nanotechnology/Materials, Molecular biochemistry
• Life sciences, Pharmaceuticals - analytical and physicochemistry

Papers

• Balance between Association and Dissociation Rate Constants Determines Morphology and Property of Amyloid Fibrils

  Taiga Nakagawa; Daisuke Tsuri; Ichiro Nishii; Naoko Kajimura; Katsumi Matsuzaki; Masaru Hoshino

  The Journal of Physical Chemistry B, 29 Nov. 2024

  
• Helicene-Fluorescein Hybrids: A Reversible Base-triggered (Chir)optical Switch with Sign Inversion of Circularly Polarized Luminescence.

  Sorachi Miwa; Daichi Mizutani; Kenichi Kawano; Katsumi Matsuzaki; Yuuya Nagata; Kazunori Tsubaki; Kiyosei Takasu; Hiroshi Takikawa

  Chemistry (Weinheim an der Bergstrasse, Germany), 30 Jan. 2025

  
• Stable and Minimum Size Solubilization of Membrane Proteins with Cocktails of Phospholipid Analogues

  Mai Takagi; Ayana Nagatani; Kenichi Kawano; Ayami Hata; Azusa Yokoyama; Koichi Hayashida; Haruka Hoshi; Mao Sakurai; Tsuyoshi Oyama; Yusuke Kuroda; Yousuke Yamaoka; Takahiro Fujiwara; Yohei Miyanoiri; Masaru Hoshino; Yoshiaki Yano; Kiyosei Takasu; Katsumi Matsuzaki

  ACS Applied Materials & Interfaces, 07 Nov. 2024

  
• Amyloid Fibril Formation on Neuronal Cells in the Coexistence of Aβ40 and Aβ42

  Mayu Kawaguchi; Kenichi Kawano; Aoi Taniguchi; Atsushi Tanaka; Katsumi Matsuzaki

  ChemBioChem, 25 Sep. 2024

  
• In-Cell FRET Indicates Magainin Peptide Induced Permeabilization of Bacterial Cell Membranes at Lower Peptide-to-Lipid Ratios Relevant to Liposomal Studies

  Takumi Kaji; Yoshiaki Yano; Katsumi Matsuzaki

  ACS Infectious Diseases, 08 Oct. 2021

  
• Extracellular-Vesicle Catch-and-Release Isolation System Using a Net-Charge Invertible Curvature-Sensing Peptide.

  Kenichi Kawano; Yuki Kuzuma; Koichi Yoshio; Kenta Hosokawa; Yuuto Oosugi; Takahiro Fujiwara; Fumiaki Yokoyama; Katsumi Matsuzaki

  Analytical chemistry, 05 Mar. 2024

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• Structural factors governing binding of curvature-sensing peptides to bacterial extracellular vesicles covered with hydrophilic polysaccharide chains

  Kenichi Kawano; Kouhei Kamasaka; Fumiaki Yokoyama; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara; Katsumi Matsuzaki

  Biophysical Chemistry, May 2023

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• Development of Antimicrobial Peptide-Antibiotic Conjugates to Improve the Outer Membrane Permeability of Antibiotics Against Gram-Negative Bacteria.

  Ruka Yamauchi; Kenichi Kawano; Yousuke Yamaoka; Aoi Taniguchi; Yoshiaki Yano; Kiyosei Takasu; Katsumi Matsuzaki

  ACS infectious diseases, 18 Oct. 2022

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• Elucidation of Complex Dynamic Intermolecular Interactions in Membranes

  Katsumi Matsuzaki

  Chem. Pharm. Bull., Jan. 2022, Peer-reviewed, Invited, Lead author, Corresponding author

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• S1h1-1 Interaction of the Archetypical Antimicrobial Peptide Magainin with Membranes : From Classics to Cutting Edge(S1-h1 "Antimicrobial Peptides and Membrane Interactions",Symposia,Abstract,Meeting Program of EABS & BSJ 2006)

  Matsuzaki Katsumi

  Seibutsu Butsuri, 2006

  
• 2I1600 Formation of a membrane-active form of amyloid-beta protein in raft-like lipid environments

  Kakio A.; Nishomoto S.; Kozutsumi Y.; Matsuzaki K.

  Seibutsu Butsuri, 2002

  
• 3P045 Formation of toxci-Aβ-(1-40) fibrils on GM1 ganglioside-containing lipid raft mimicking membranes(Proteins-stability, folding, and other physicochemical properties,Poster Presentations)

  Okada Takuma; Ikeda Keisuke; Matsuzaki Katsumi

  Seibutsu Butsuri, 2007

  
• 1P105 Measurement of thermodynamic parameters for self-association of a transmembrane helix in lipid bilayers containing cholesterol(Membrane proteins,Oral Presentations)

  Yamamoto Arisa; Yano Yoshiaki; Matsuzaki Katsumi

  Seibutsu Butsuri, 2007

  
• 1P104 Design of a soluble transmembrane helix for measurement of water-membrane partitioning(Membrane proteins,Oral Presentations)

  Shimai Norie; Yano Yoshiaki; Matsuzaki Katsumi

  Seibutsu Butsuri, 2007

  
• 2SC04 Aggregation of Alzheimer's Amyloid beta-Protein via Ganglioside Cluster

  Matsuzaki K.

  Seibutsu Butsuri, 2005

  
• 3P121 Effect of hydrophobic mismatch on thermodynamics for self-association of a trasmembrane helix

  Yano Y.; Matsuzaki K.

  Seibutsu Butsuri, 2005

  
• New aspects of interaction between ceramide and glycerophospholipids

  Sato SB; Kurumada S.; Yano Y.; Matsuzaki K.; Kobayashi T.

  Seibutsu Butsuri, 2005

  
• 1P062 Visualization of the interaction between amyloid-beta-protein and GM1-ganglioside

  Wakabayashi M.; Matsuzaki K.

  Seibutsu Butsuri, 2004

  
• 1P115 Measurement of thermodynamic parameters for intervesicular transfer of a transmembrane helix

  Ogura M.; Yano Y.; Matsuzaki K.

  Seibutsu Butsuri, 2004

  
• Measurement of thermodynamic parameters for self-association of a model transmembrane helix in lipid bilayers.

  Yano Y.; Ogura M.; Matsuzaki K.

  Seibutsu Butsuri, 2003

  
• Stability and self aggregation of a model transmembrane helix in lipid bilayers

  Yano Y.; Takemoto T.; Kobayashi S; Ohashi W.; Niwa M.; Futaki S.; Sugiura Y.; Matsuzaki K.

  Seibutsu Butsuri, 2000

  
• Interaction of an hydrophobic peptide with lipid bilayers.

  Matsuzaki K.; Takemoto T.; Yano Y.; Kobayashi S.

  Seibutsu Butsuri, 1999

  
• 2G1648 Construction of the chaperonin-encapsulation system(Protein: Structure 2,The 48th Annual Meeting of the Biophysical Society of Japan)

  Ishino So; Masuhara Yasuhide; Kawata Yasushi; Matsuzaki Katsumi; Hoshino Masaru

  Seibutsu Butsuri, 2011

  
• 1A1312 Mechanism of amyloid formation by Aβ in raft-like membranes containing ganglioside clusters(Biol & Artifi memb 1: Structure & Property, Dynamics,The 49th Annual Meeting of the Biophysical Society of Japan)

  Ikeda Keisuke; Yamaguchi Takahiro; Fukunaga Saori; Hoshino Masaru; Matsuzaki Katsumi

  Seibutsu Butsuri, 2011

  
• 2SB-01 Behaviors of receptors as analyzed by novel fluorescence labeling method for membrane proteins(2SB Frontiers in chemical biology for in-cell biophysics,The 49th Annual Meeting of the Biophysical Society of Japan)

  Matsuzaki Katsumi

  Seibutsu Butsuri, 2011

  
• 3B0924 Thermodynamics of insertion and self-association of a transmembrane helix : A lipophobic intercation by phosphatidylethanolamine(3B Membrane proteins 2,The 49th Annual Meeting of the Biophysical Society of Japan)

  Yano Yoshiaki; Yamamoto Arisa; Ogura Mai; Matsuzaki Katsumi

  Seibutsu Butsuri, 2011

  
• 1P120 1I1240 Fluctuations of interaction between transmembrane helices as detected by single-molecule fluorescence microscopy(Membrane proteins,Oral Presentations,The 48th Annual Meeting of the Biophysical Society of Japan)

  Yano Yoshiaki; Kitani Ryota; Matsuzaki Katsumi

  Seibutsu Butsuri, 2010

  
• 2P-051 Mechanism of amyloid β-protein aggregation mediated by GM1 ganglioside cluster(Protein:Property,The 47th Annual Meeting of the Biophysical Society of Japan)

  Ikeda Keisuke; Hoshino Masaru; Matsuzaki Katsumi

  Seibutsu Butsuri, 2009

  
• 3P-061 A novel method for the structural analysis of self-associating proteins by high-resolution solution NMR spectroscopy(The 46th Annual Meeting of the Biophysical Society of Japan)

  Tanaka Shinji; Kawata Yasushi; Matsuzaki Katsumi; Hoshino Masaru

  Seibutsu Butsuri, 2008

  
• 2H1645 Membrane insertion and dissociation processes of a transmembrane helix

  Yano Yoshiaki; Matsuzaki Katsumi

  Seibutsu Butsuri, 2002

  
• Analysis of GXXXG-mediated Association of Transmembrane Helices as Studied by Single-pair Fluorescence and 2D-IR Spectroscopy

  YANO Yoshiaki; MATSUZAKI Katsumi

  Seibutsu Butsuri, 2017

  
• All-Atom Molecular Dynamics Elucidating Molecular Mechanisms of Single-Transmembrane Model Peptide Dimerization in a Lipid Bilayer

  Hayato Itaya; Kota Kasahara; Qilin Xie; Yoshiaki Yano; Katsumi Matsuzaki; Takuya Takahashi

  ACS Omega, 04 May 2021, Peer-reviewed

  
• Thermodynamic and kinetic stabilities of transmembrane helix bundles as revealed by single-pair FRET analysis: Effects of the number of membrane-spanning segments and cholesterol

  Yoshiaki Yano; Yuta Watanabe; Katsumi Matsuzaki

  Biochimica et Biophysica Acta (BBA) - Biomembranes, Mar. 2021, Peer-reviewed, Corresponding author

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• Improvement of Therapeutic Index by the Combination of Enhanced Peptide Cationicity and Proline Introduction

  Erika Azuma; Naoki Choda; Mayu Odaki; Yoshiaki Yano; Katsumi Matsuzaki

  ACS Infectious Diseases, 14 Aug. 2020, Peer-reviewed, Corresponding author

  
• Aβ–ganglioside interactions in the pathogenesis of Alzheimer's disease

  Katsumi Matsuzaki

  Biochimica et Biophysica Acta (BBA) - Biomembranes, Aug. 2020, Peer-reviewed, Invited, Lead author, Corresponding author

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• Molecular Mechanism of Apoptosis by Amyloid β-Protein Fibrils Formed on Neuronal Cells

  Eri Takada; Kaori Okubo; Yoshiaki Yano; Keiko Iida; Masataka Someda; Akira Hirasawa; Shin Yonehara; Katsumi Matsuzaki

  ACS Chemical Neuroscience, 04 Mar. 2020, Peer-reviewed, Corresponding author

  
• Structural characterization of the N-terminal kinase-interacting domain of an Hsp90-cochaperone Cdc37 by CD and solution NMR spectroscopy.

  Futoshi Ihama; Mami Yamamoto; Chojiro Kojima; Toshimichi Fujiwara; Katsumi Matsuzaki; Yoshihiko Miyata; Masaru Hoshino

  Biochimica et biophysica acta. Proteins and proteomics, Sep. 2019, Peer-reviewed

  
• Meeting Peptides in Kyoto.

  Futaki S; Matsuzaki K; Goto Y

  Chembiochem : a European journal of chemical biology, Aug. 2019, Peer-reviewed

  
• Endowment of pH responsivity to anticancer peptides by introducing 2,3-diaminopropionic acid residues.

  Tanishiki N; Yano Y; Matsuzaki K

  Chembiochem : a European journal of chemical biology, Jun. 2019, Peer-reviewed

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• Live-cell imaging of membrane proteins by a coiled-coil labeling method-Principles and applications.

  Yano Y; Matsuzaki K

  Biochimica et biophysica acta. Biomembranes, May 2019, Peer-reviewed

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• Computational Study on the Assembly of Amyloid β-Peptides in the Hydrophobic Environment.

  Qu L; Fudo S; Matsuzaki K; Hoshino T

  Chemical & pharmaceutical bulletin, 2019, Peer-reviewed

  
• [Fluorescent Peptide Tools for Studying the Self-association of Membrane Proteins].

  Yano Y; Matsuzaki K

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2019, Peer-reviewed

  
• Membrane Permeabilization Mechanisms.

  Matsuzaki K

  Advances in experimental medicine and biology, 2019, Peer-reviewed

  
• Toxic Amyloid Tape: A Novel Mixed Antiparallel/Parallel β-Sheet Structure Formed by Amyloid β-Protein on GM1 Clusters.

  Okada Y; Okubo K; Ikeda K; Yano Y; Hoshino M; Hayashi Y; Kiso Y; Itoh-Watanabe H; Naito A; Matsuzaki K

  ACS chemical neuroscience, Jan. 2019, Peer-reviewed

  
• Analysis of Physicochemical Interaction of Aβ40 with a GM1 Ganglioside-Containing Lipid Membrane

  Majid Vahed; Saburo Neya; Katsumi Matsuzaki; Tyuji Hoshino

  Journal of Physical Chemistry B, 12 Apr. 2018, Peer-reviewed

  
• Not Oligomers but Amyloids are Cytotoxic in the Membrane-Mediated Amyloidogenesis of Amyloid-β Peptides

  Naoya Itoh; Eri Takada; Kaori Okubo; Yoshiaki Yano; Masaru Hoshino; Akira Sasaki; Masataka Kinjo; Katsumi Matsuzaki

  ChemBioChem, 02 Mar. 2018, Peer-reviewed

  
• High performance plasma amyloid-β biomarkers for Alzheimer's disease.

  Akinori Nakamura; Naoki Kaneko; Victor L Villemagne; Takashi Kato; James Doecke; Vincent Doré; Chris Fowler; Qiao-Xin Li; Ralph Martins; Christopher Rowe; Taisuke Tomita; Katsumi Matsuzaki; Kenji Ishii; Kazunari Ishii; Yutaka Arahata; Shinichi Iwamoto; Kengo Ito; Koichi Tanaka; Colin L Masters; Katsuhiko Yanagisawa

  Nature, 08 Feb. 2018, Peer-reviewed

  
• Ganglioside-Mediated Assembly of Amyloid β-Protein: Roles in Alzheimer's Disease

  Katsumi Matsuzaki; Koichi Kato; Katsuhiko Yanagisawa

  Progress in Molecular Biology and Translational Science, 01 Jan. 2018, Peer-reviewed

  
• Simulation Study on Complex Conformations of Aβ₄₂ Peptides on a GM1 Ganglioside-Containing Lipid Membrane.

  Vahed M; Neya S; Matsuzaki K; Hoshino T

  Chemical & pharmaceutical bulletin, 2018, Peer-reviewed

  
• Trace amounts of pyroglutaminated Aβ-(3–42) enhance aggregation of Aβ-(1–42) on neuronal membranes at physiological concentrations: FCS analysis of cell surface

  Yoshiaki Yano; An Takeno; Katsumi Matsuzaki

  Biochimica et Biophysica Acta - Biomembranes, 2018, Peer-reviewed

  
• Identification of heteromolecular binding sites in transcription factors Sp1 and TAF4 using high-resolution nuclear magnetic resonance spectroscopy

  Emi Hibino; Rintaro Inoue; Masaaki Sugiyama; Jun Kuwahara; Katsumi Matsuzaki; Masaru Hoshino

  PROTEIN SCIENCE, Nov. 2017, Peer-reviewed

  
• Stoichiometric analysis of oligomeric states of three class-A GPCRs, chemokine-CXCR4, dopamine-D2, and prostaglandin-EP1 receptors, on living cells

  Kenichi Kawano; Tetsuya Yagi; Nozomu Fukada; Yoshiaki Yano; Katsumi Matsuzaki

  JOURNAL OF PEPTIDE SCIENCE, Jul. 2017, Peer-reviewed

  
• Aromaticity of Phenylalanine Residues Is Essential for Amyloid Formation by Alzheimer's Amyloid beta-Peptide

  Mayumi Genji; Yoshiaki Yano; Masaru Hoshino; Katsumi Matsuzaki

  CHEMICAL & PHARMACEUTICAL BULLETIN, Jul. 2017, Peer-reviewed

  
• A pH-dependent charge reversal peptide for cancer targeting

  Naoko Wakabayashi; Yoshiaki Yano; Kenichi Kawano; Katsumi Matsuzaki

  EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Mar. 2017, Peer-reviewed

  
• GXXXG-Mediated Parallel and Antiparallel Dimerization of Transmembrane Helices and Its Inhibition by Cholesterol: Single-Pair FRET and 2D IR Studies

  Yoshiaki Yano; Kotaro Kondo; Yuta Watanabe; Tianqi O. Zhang; Jia-Jung Ho; Shinya Oishi; Nobutaka Fujii; Martin T. Zanni; Katsumi Matsuzaki

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Feb. 2017, Peer-reviewed

  
• Interaction between intrinsically disordered regions in transcription factors Sp1 and TAF4

  Emi Hibino; Rintaro Inoue; Masaaki Sugiyama; Jun Kuwahara; Katsumi Matsuzaki; Masaru Hoshino

  PROTEIN SCIENCE, Nov. 2016, Peer-reviewed

  
• Selective Amine Labeling of Cell Surface Proteins Guided by Coiled-Coil Assembly

  Yoshiaki Yano; Nami Furukawa; Satoshi Ono; Yuki Takeda; Katsumi Matsuzaki

  BIOPOLYMERS, Jul. 2016, Peer-reviewed

  
• Oligomerization-function relationship of EGFR on living cells detected by the coiled-coil labeling and FRET microscopy

  Hirotaka Yamashita; Yoshiaki Yano; Kenichi Kawano; Katsumi Matsuzaki

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Jun. 2015, Peer-reviewed

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• Effects of C-terminal Truncation of Chaperonin GroEL on the Yield of In-cage Folding of the Green Fluorescent Protein

  So Ishino; Yasushi Kawata; Hideki Taguchi; Naoko Kajimura; Katsumi Matsuzaki; Masaru Hoshino

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2015, Peer-reviewed

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• Oligomerization-function relationship of EGFR on living cells detected by the coiled-coil labeling and FRET microscopy.

  Yamashita H; Yano Y; Kawano K; Matsuzaki K

  Biochimica et biophysica acta, Jun. 2015, Peer-reviewed

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• Cholesterol-Induced Lipophobic Interaction between Transmembrane Helices Using Ensemble and Single-Molecule Fluorescence Resonance Energy Transfer

  Yoshiaki Yano; Kotaro Kondo; Ryota Kitani; Arisa Yamamoto; Katsumi Matsuzaki

  BIOCHEMISTRY, Feb. 2015, Peer-reviewed

  
• Comparison between the Aggregation of Human and Rodent Amyloid beta-Proteins in GM1 Ganglioside Clusters

  Hiroshi Ueno; Takahiro Yamaguchi; Saori Fukunaga; Yuki Okada; Yoshiaki Yano; Masaru Hoshino; Katsumi Matsuzaki

  BIOCHEMISTRY, Dec. 2014, Peer-reviewed

  
• How Do Membranes Initiate Alzheimer's Disease? Formation of Toxic Arnyloid Fibrils by the Amyloid beta-Protein on Ganglioside Clusters

  Katsumi Matsuzaki

  ACCOUNTS OF CHEMICAL RESEARCH, Aug. 2014, Peer-reviewed

  
• A Dimer Is the Minimal Proton-Conducting Unit of the Influenza A Virus M2 Channel

  Kenichi Kawano; Yoshiaki Yano; Katsumi Matsuzaki

  JOURNAL OF MOLECULAR BIOLOGY, Jul. 2014, Peer-reviewed

  
• Evaluation of the stability of an SR398/GroES chaperonin complex

  So Ishino; Yasushi Kawata; Takahisa Ikegami; Katsumi Matsuzaki; Masaru Hoshino

  JOURNAL OF BIOCHEMISTRY, May 2014, Peer-reviewed

  
• A Visualization Tool for Oligomerization and Internalization of Membrane Proteins in Living Cells: Coiled-Coil Labeling Method

  Yoshiaki Yano; Kenichi Kawano; Kaoru Omae; Yuki Takeda; Sayaka Matsuzaki; Katsumi Matsuzaki

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Apr. 2014, Peer-reviewed

  
• 1P217 Contributions of GXXXG motif to transmembrane helical interactions as revealed by single molecule FRET(13B. Biological & Artificial membrane: Dynamics,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))

  Kondo Kotaro; Yano Yoshiaki; Matsuzaki Katsumi

  Seibutsu Butsuri, 2014

  
• 3SEA-05 The interaction between transcription factors Sp1 and TAF4 via the intrinsically disordered regions(Frontiers in physical properties of proteins: challenges by young scientists,Symposium,The 52th Annual Meeting of the Biophysical Society of Japan(BSJ2014))

  Hibino Emi; Inoue Rintaro; Sugiyama Masaaki; Kuwahara Jun; Matsuzaki Katsumi; Hoshino Masaru

  Seibutsu Butsuri, 2014

  
• 1P075 Effect of C-terminal truncation of chaperonin GroEL on the yield of an in-cage folding of GFP(01D. Protein : Function,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))

  Ishino So; Kawata Yasushi; Taguchi Hideki; Matsuzaki Katsumi; Hoshino Masaru

  Seibutsu Butsuri, 2014

  
• Effects of pyrenebutyrate on the translocation of arginine-rich cell-penetrating peptides through artificial membranes: Recruiting peptides to the membranes, dissipating liquid-ordered phases, and inducing curvature

  Sayaka Katayama; Ikuhiko Nakase; Yoshiaki Yano; Tomo Murayama; Yasushi Nakata; Katsumi Matsuzaki; Shiroh Futaki

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Sep. 2013, Peer-reviewed

  
• Binding and Aggregation Mechanism of Amyloid beta-Peptides onto the GM1 Ganglioside-Containing Lipid Membrane

  Tyuji Hoshino; Md. Iqbal Mahmood; Kenichi Mori; Katsumi Matsuzaki

  JOURNAL OF PHYSICAL CHEMISTRY B, Jul. 2013, Peer-reviewed

  
• Interaction between soluble Aβ-(1-40) monomer and Aβ-(1-42) fibrils probed by paramagnetic relaxation enhancement

  Takahiro Yamaguchi; Katsumi Matsuzaki; Masaru Hoshino

  FEBS Letters, 18 Mar. 2013, Peer-reviewed

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• Stoichiometric Analysis of Oligomerization of Membrane Proteins on Living Cells Using Coiled-Coil Labeling and Spectral Imaging

  Kenichi Kawano; Yoshiaki Yano; Kaoru Omae; Sayaka Matsuzaki; Katsumi Matsuzaki

  ANALYTICAL CHEMISTRY, Mar. 2013, Peer-reviewed

  
• Image Analysis of Membrane Receptors in Living Cells by Coiled-coil Labeling Method

  YANO Yoshiaki; MATSUZAKI Katsumi

  MEMBRANE, 01 Mar. 2013

  
• 1P297 Development of methods for labeling and oligomerization analysis of membrane proteins in live cells(27. Bioimaging,Poster)

  Yano Yoshiaki; Kawano Kenichi; Omae Kaoru; Mtsuzaki Sayaka; Matsuzaki Katsumi

  Seibutsu Butsuri, 2013

  
• 3SEA-01 Ganglioside Cluster-Mediated Folding and Aggregation of Alzheimer's Amyloid beta-Protein(3SEA Roles of Membrane Interface in amyloidogenesis,Symposium)

  Matsuzaki Katsumi

  Seibutsu Butsuri, 2013

  
• Interaction of Antimicrobial Peptide Magainin 2 with Gangliosides as a Target for Human Cell Binding

  Yu Miyazaki; Megumi Aoki; Yoshiaki Yano; Katsumi Matsuzaki

  BIOCHEMISTRY, Dec. 2012, Peer-reviewed

  
• GM1 Cluster Mediates Formation of Toxic A beta Fibrils by Providing Hydrophobic Environments

  Saori Fukunaga; Hiroshi Ueno; Takahiro Yamaguchi; Yoshiaki Yano; Masaru Hoshino; Katsumi Matsuzaki

  BIOCHEMISTRY, Oct. 2012, Peer-reviewed

  
• Interaction between isolated transcriptional activation domains of Sp1 revealed by heteronuclear magnetic resonance

  Naoko Hiramatsu; Emi Hibino; Katsumi Matsuzaki; Jun Kuwahara; Masaru Hoshino

  PROTEIN SCIENCE, Oct. 2012, Peer-reviewed

  
• Paradoxical Downregulation of CXC Chemokine Receptor 4 Induced by Polyphemusin II-Derived Antagonists

  Ryo Masuda; Shinya Oishi; Noriko Tanahara; Hiroaki Ohno; Akira Hirasawa; Gozoh Tsujimoto; Yoshiaki Yano; Katsumi Matsuzaki; Jean-Marc Navenot; Stephen C. Peiper; Nobutaka Fujii

  BIOCONJUGATE CHEMISTRY, Jun. 2012, Peer-reviewed

  
• Formation of GM1 Ganglioside Clusters on the Lipid Membrane Containing Sphingomyeline and Cholesterol

  Kenichi Mori; Md. Iqbal Mahmood; Saburo Neya; Katsumi Matsuzaki; Tyuji Hoshino

  JOURNAL OF PHYSICAL CHEMISTRY B, May 2012, Peer-reviewed

  
• High-Throughput Analysis of Ligand-Induced Internalization of beta(2)-Adrenoceptors Using the Coiled-Coil Tag-Probe Method

  Yuki Takeda; Yoshiaki Yano; Katsumi Matsuzaki

  ANALYTICAL CHEMISTRY, Feb. 2012, Peer-reviewed

  
• Molecular Mechanism Underlying Initiation of Amyloidogenesis and Its Application to Development of Disease-Modifying Drugs for Alzheimer Disease

  柳澤勝彦; 松崎勝巳; 加藤晃一

  最新医学 、67、138-158 （2012）, 2012

  
• COOLED-COIL TAG-PROBE LABELING METHODS FOR LIVE-CELL IMAGING OF MEMBRANE RECEPTORS

  Yoshiaki Yano; Kenichi Kawano; Kaoru Omae; Katsumi Matsuzaki

  IMAGING AND SPECTROSCOPIC ANALYSIS OF LIVING CELLS: OPTICAL AND SPECTROSCOPIC TECHNIQUES, 2012, Peer-reviewed

  
• Improvement of probe peptides for coiled-coil labeling by introducing phosphoserines

  Satoshi Ono; Yoshiaki Yano; Katsumi Matsuzaki

  BIOPOLYMERS, 2012, Peer-reviewed

  
• Bifunctional Hydrogen-Bond Donors That Bear a Quinazoline or Benzothiadiazine Skeleton for Asymmetric Organocatalysis

  Tsubasa Inokuma; Masaya Furukawa; Takuya Uno; Yusuke Suzuki; Kohzo Yoshida; Yoshiaki Yano; Katsumi Matsuzaki; Yoshiji Takemoto

  CHEMISTRY-A EUROPEAN JOURNAL, Sep. 2011, Peer-reviewed

  
• Thermodynamics of Insertion and Self-Association of a Transmembrane Helix: A Lipophobic Interaction by Phosphatidylethanolamine

  Yoshiaki Yano; Arisa Yamamoto; Mai Ogura; Katsumi Matsuzaki

  BIOCHEMISTRY, Aug. 2011, Peer-reviewed

  
• Mechanism of Amyloid beta-Protein Aggregation Mediated by GM1 Ganglioside Clusters

  Keisuke Ikeda; Takahiro Yamaguchi; Saori Fukunaga; Masaru Hoshino; Katsumi Matsuzaki

  BIOCHEMISTRY, Jul. 2011, Peer-reviewed

  
• Fluorescence ratiometric detection of ligand-induced receptor internalization using extracellular coiled-coil tag-probe labeling

  Yoshiaki Yano; Katsumi Matsuzaki

  FEBS LETTERS, Jul. 2011, Peer-reviewed

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• Lacticin Q-Mediated Selective Toxicity Depending on Physicochemical Features of Membrane Components

  Fuminori Yoneyama; Kanako Ohno; Yuichi Imura; Mengqi Li; Takeshi Zendo; Jiro Nakayama; Katsumi Matsuzaki; Kenji Sonomoto

  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, May 2011, Peer-reviewed

  
• Transient formation of intermediate conformational states of amyloid-beta peptide revealed by heteronuclear magnetic resonance spectroscopy

  Takahiro Yamaguchi; Katsumi Matsuzaki; Masaru Hoshino

  FEBS LETTERS, Apr. 2011, Peer-reviewed

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• A novel hybrid peptide targeting EGFR-expressing cancers

  Masayuki Kohno; Tomohisa Horibe; Mari Haramoto; Yoshiaki Yano; Koji Ohara; Oumi Nakajima; Katsumi Matsuzaki; Koji Kawakami

  EUROPEAN JOURNAL OF CANCER, Mar. 2011, Peer-reviewed

  
• Ganglioside-mediated aggregation of amyloid beta-proteins (A beta): comparison between A beta-(1-42) and A beta-(1-40)

  Mariko Ogawa; Miho Tsukuda; Takahiro Yamaguchi; Keisuke Ikeda; Takuma Okada; Yoshiaki Yano; Masaru Hoshino; Katsumi Matsuzaki

  JOURNAL OF NEUROCHEMISTRY, Mar. 2011, Peer-reviewed

  
• Formation of toxic amyloid fibrils by amyloid β-protein on ganglioside clusters

  Katsumi Matsuzaki

  International Journal of Alzheimer's Disease, 2011, Peer-reviewed

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• A Disulfide-Linked Amyloid-beta Peptide Dimer Forms a Protofibril-like Oligomer through a Distinct Pathway from Amyloid Fibril Formation

  Takahiro Yamaguchi; Hisashi Yagi; Yuji Goto; Katsumi Matsuzaki; Masaru Hoshino

  BIOCHEMISTRY, Aug. 2010, Peer-reviewed

  
• A beta polymerization through interaction with membrane gangliosides

  Katsumi Matsuzaki; Koichi Kato; Katsuhiko Yanagisawa

  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Aug. 2010, Peer-reviewed

  
• Solubility enhancement of hydrophobic compounds by cosolvents: Role of solute hydrophobicity on the solubilization effect

  Yasuhiro Miyako; Nawel Khalef; Katsumi Matsuzaki; Rodolfo Pinal

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Jun. 2010, Peer-reviewed

  
• Ganglioside Cluster-mediated Aggregation and Cytotoxicity of Amyloid beta-Peptide: Molecular Mechanism and Inhibitionl

  Katsumi Matsuzaki

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Apr. 2010, Peer-reviewed

  
• Chaperonin-encapsulation of proteins for NMR

  Shinji Tanaka; Yasushi Kawata; Gottfried Otting; Nicholas E. Dixon; Katsumi Matsuzaki; Masaru Hoshino

  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, Apr. 2010, Peer-reviewed

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• Design of a Soluble Transmembrane Helix for Measurements of Water-Membrane Partitioning

  Yoshiaki Yano; Norie Shimai; Katsumi Matsuzaki

  JOURNAL OF PHYSICAL CHEMISTRY B, Feb. 2010, Peer-reviewed

  
• Visualization of membrane receptor internalization by novel fluorescent labeling method

  Katsumi Matsuzaki; Yoshiaki Yano

  Seikagaku, 2010, Peer-reviewed

  
• Tag-probe labeling methods for live-cell imaging of membrane proteins

  Yoshiaki Yano; Katsumi Matsuzaki

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Oct. 2009, Peer-reviewed

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• Ganglioside-induced amyloid formation by human islet amyloid polypeptide in lipid rafts

  Masaki Wakabayashi; Katsumi Matsuzaki

  FEBS LETTERS, Sep. 2009, Peer-reviewed

  
• Peptide-Lipid Huge Toroidal Pore, a New Antimicrobial Mechanism Mediated by a Lactococcal Bacteriocin, Lacticin Q

  Fuminori Yoneyama; Yuichi Imura; Kanako Ohno; Takeshi Zendo; Jiro Nakayama; Katsumi Matsuzaki; Kenji Sonomoto

  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Aug. 2009, Peer-reviewed

  
• Solution NMR studies of amphibian antimicrobial peptides: Linking structure to function?

  Evan F. Haney; Howard N. Hunter; Katsumi Matsuzaki; Hans J. Vogel

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Aug. 2009, Peer-reviewed

  
• Control of cell selectivity of antimicrobial peptides

  Katsumi Matsuzaki

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Aug. 2009, Peer-reviewed

  
• "Click Peptide": pH-Triggered in Situ Production and Aggregation of Monomer A beta 1-42

  Atsuhiko Taniguchi; Youhei Sohma; Yuta Hirayama; Hidehito Mukai; Tooru Kimura; Yoshio Hayashi; Katsumi Matsuzaki; Yoshiaki Kiso

  CHEMBIOCHEM, Mar. 2009, Peer-reviewed

  
• Lacticin Q, a Lactococcal Bacteriocin, Causes High-Level Membrane Permeability in the Absence of Specific Receptors

  Fuminori Yoneyama; Yuichi Imura; Shiro Ichimasa; Koji Fujita; Takeshi Zendo; Jiro Nakayama; Katsumi Matsuzaki; Kenji Sonomoto

  APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Jan. 2009, Peer-reviewed

  
• 「膜」：「特集にあたって」［３‐１］膜における動的分子間相互作用

  松崎 勝己

  アンサンブル, 2009

  
• Controlled Production of Amyloid beta Peptide from a Photo-Triggered, Water-Soluble Precursor "Click Peptide"

  Atsuhiko Taniguchi; Mariusz Skwarczynski; Youhei Sohma; Takuma Okada; Keisuke Ikeda; Halan Prakash; Hidehito Mukai; Yoshio Hayashi; Tooru Kimura; Shun Hirota; Katsumi Matsuzaki; Yoshiaki Kiso

  CHEMBIOCHEM, Dec. 2008, Peer-reviewed

  
• Magainin 2 in Action: Distinct Modes of Membrane Permeabilization in Living Bacterial and Mammalian Cells

  Yuichi Imura; Naoki Choda; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Dec. 2008, Peer-reviewed

  
• Formation of toxic A beta(1-40) fibrils on GM1 ganglioside-containing membranes mimicking lipid rafts: Polymorphisms in A beta(1-40) fibrils

  Takuma Okada; Keisuke Ikeda; Masaki Wakabayashi; Mariko Ogawa; Katsumi Matsuzaki

  JOURNAL OF MOLECULAR BIOLOGY, Oct. 2008, Peer-reviewed

  
• Development of water-soluble click peptides by use of the O-acyl isopeptide method: in situ production of Alzheimer fs amyloid beta peptide

  Atsuhiko Taniguchi; Youhei Sohma; Mariusz Skwarczynski; Takami Nagano; Takuma Okada; Keisuke Ikeda; Halan Prakash; Hidehito Mukai; Yoshio Hayashi; Tooru Kimura; Shun Hirota; Katsumi Matsuzaki; Yoshiaki Kiso

  JOURNAL OF PEPTIDE SCIENCE, Aug. 2008, Peer-reviewed

  
• Intracellular third loop-C-terminal tail interaction in prostaglandin EP3 beta receptor

  Yoshiaki Yano; Takuya Shimbo; Yukihiko Sugimoto; Katsumi Matsuzaki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 2008, Peer-reviewed

  
• Design, synthesis, and biophysical properties of a helical A beta 1-42 analog: Inhibition of fibrillogenesis and cytotoxicity

  Katsumi Matsuzaki; Takuma Okada; Miho Tsukuda; Keisuke Ikeda; Youhei Sohma; Yousuke Chiyomori; Atsuhiko Taniguchi; Setsuko Nakamura; Nui To; Yoshio Hayashi; Yoshiaki Kiso

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 2008, Peer-reviewed

  
• Coiled-coil tag - Probe system for quick labeling of membrane receptors in living cells

  Yoshiaki Yano; Akiko Yano; Shinya Oishi; Yukihiko Sugimoto; Gozoh Tsujimoto; Nobutaka Fujii; Katsumi Matsuzaki

  ACS CHEMICAL BIOLOGY, Jun. 2008, Peer-reviewed

  
• Driving force of binding of amyloid beta-protein to lipid bilayers

  Keisuke Ikeda; Katsumi Matsuzaki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2008, Peer-reviewed

  
• Interaction of a magainin-PGLa hybrid peptide with membranes: Insight into the mechanism of synergism

  Minoru Nishida; Yuichi Imura; Megumi Yamamoto; Satoe Kobayashi; Yoshiaki Yano; Katsumi Matsuzaki

  BIOCHEMISTRY, Dec. 2007, Peer-reviewed

  
• 3P328 Specific fluorescence labeling of membrane receptors in living cells using peptide-peptide interaction(Bioimaging. Behavior. Development and differentiation. Molecular genetics. Others,Oral Presentations)

  Yano Yoshiaki; Yano Akiko; Sugimoto Yukihiko; Matsuzaki Katsumi

  Seibutsu Butsuri, 20 Nov. 2007

  
• Action mechanism of PEGylated magainin 2 analogue peptide

  Yuichi Imura; Minoru Nishida; Katsumi Matsuzaki

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Oct. 2007, Peer-reviewed

  
• Physicochernical interactions of arnyloid-peptide with lipid bilayers

  Katsumi Matsuzaki

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Aug. 2007, Peer-reviewed

  
• Preface to the special issue on amyloidogenic protein-membrane interaction

  Katsumi Matsuzaki

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Aug. 2007, Peer-reviewed

  
• Formation of amyloids by a beta-(1-42) on NGF-differentiated PC12 cells: roles of Gangliosides and cholesterol

  Masaki Wakabayashi; Katsumi Matsuzaki

  JOURNAL OF MOLECULAR BIOLOGY, Aug. 2007, Peer-reviewed

  
• Formation of toxic fibrils of Alzheimer's amyloid beta-protein-(1-40) by monosialoganglioside GM1, a neuronal membrane component

  Takuma Okada; Masaki Wakabayashi; Keisuke Ikeda; Katsumi Matsuzaki

  JOURNAL OF MOLECULAR BIOLOGY, Aug. 2007, Peer-reviewed

  
• Roles of Biomembranes in the Aggregation of Alzheimer's Amyloid β-Protein

  MATSUZAKI Katsumi

  MEMBRANE, 01 Jul. 2007, Peer-reviewed

  
• Action mechanism of tachyplesin I and effects of PEGylation

  Yuichi Imura; Minoru Nishida; Yoshiyuki Ogawa; Yoshinobu Takakura; Katsumi Matsuzaki

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, May 2007, Peer-reviewed

  
• Roles of Biomembranes in the Formation of A.BETA. Amyloid

  松崎勝巳

  細胞工学, 22 Jan. 2007, Peer-reviewed

  
• Formation of toxic fibrils of amyloid beta-protein-(1-40) by monosialoganglioside GM1, a neuronal membrane component

  Takuma Okada; Masaki Wakabayashi; Keisuke Ikeda; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2007, Peer-reviewed

  
• Inhibitors of amyloid beta-protein aggregation mediated by GM1-containing raft-like membranes

  Katsumi Matsuzaki; Taeko Noguch; Masaki Wakabayashi; Keisuke Ikeda; Takuma Okada; Yumiko Ohashi; Masaru Hoshino; Hironobu Naiki

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Jan. 2007, Peer-reviewed

  
• [要修正] 生細胞タンパク質の可視化--蛍光タンパク質からケミカルラベルへ

  松﨑 勝巳

  化学,61, 66-67, 2007, Peer-reviewed

  
• Inhibition of the formation of amyloid beta-protein fibrils using biocompatible nanogels as artificial chaperones

  Keisuke Ikeda; Takuma Okada; Shin-ichi Sawada; Kazunari Akiyoshi; Katsumi Matsuzaki

  FEBS LETTERS, Dec. 2006, Peer-reviewed

  
• 'Click peptide': a novel 'O-acyl isopeptide method' for peptide synthesis and chemical biology-oriented synthesis of amyloid beta peptide analogues

  Youhei Sohma; Atsuhiko Taniguchi; Taku Yoshiya; Yousuke Chiyomori; Fukue Fukao; Setsuko Nakamura; Mariusz Skwarczynski; Takuma Okada; Keisuke Ikeda; Yoshio Hayashi; Tooru Kimura; Shun Hirota; Katsumi Matsuzaki; Yoshiaki Kiso

  JOURNAL OF PEPTIDE SCIENCE, Dec. 2006, Peer-reviewed

  
• Biantennary glycans as well as genetic variants of alpha(1)-acid glycoprotein control the enantioselectivity and binding affinity of oxybutynin

  T Kimura; A Shibukawa; K Matsuzaki

  PHARMACEUTICAL RESEARCH, May 2006, Peer-reviewed

  
• “Click peptide” based on the “O-acyl isopeptide method”: chemical biology-oriented synthesis of a photo-triggered Ab1?42 analogue

  Taniguchi, A; Sohma, Y; Hayashi, Y; Hirota, S; Matsuzaki, K; Kiso, Y

  Seventh Tetrahedron Symposium, 01 Apr. 2006

  
• Measurement of thermodynamic parameters for hydrophobic mismatch 2: Intermembrane transfer of a transmembrane helix

  Y Yano; M Ogura; K Matsuzaki

  BIOCHEMISTRY, Mar. 2006, Peer-reviewed

  
• Measurement of thermodynamic parameters for hydrophobic mismatch 1: Self-association of a transmembrane helix

  Y Yano; K Matsuzaki

  BIOCHEMISTRY, Mar. 2006, Peer-reviewed

  
• "Click peptide" based on the "O-acyl isopeptide method": Control of A beta 1-42 production from a photo-triggered A beta 1-42 analogue

  A Taniguchi; Y Sohma; M Kimura; T Okada; K Ikeda; Y Hayashi; T Kimura; S Hirota; K Matsuzaki; Y Kiso

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jan. 2006, Peer-reviewed

  
• Cross-seeding of wild-type and hereditary variant-type amyloid beta-proteins in the presence of gangliosides

  N Yamamoto; K Matsuzaki; K Yanagisawa

  JOURNAL OF NEUROCHEMISTRY, Nov. 2005, Peer-reviewed

  
• Simultaneous determination of unbound thyroid hormones in human plasma using high performance frontal analysis with electrochemical detection

  T Kimura; K Nakanishi; T Nakagawa; A Shibukawa; K Matsuzaki

  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Jun. 2005, Peer-reviewed

  
• High-performance frontal analysis of the binding of thyroxine enantiomers to human serum albumin

  T Kimura; K Nakanishi; T Nakagawa; A Shibukawa; K Matsuzaki

  PHARMACEUTICAL RESEARCH, Apr. 2005, Peer-reviewed

  
• GM1 ganglioside-mediated accumulation of amyloid beta-protein on cell membranes

  M Wakabayashi; T Okada; Y Kozutsumi; K Matsuzaki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2005, Peer-reviewed

  
• On-line capillary isoelectric focusing-mass spectrometry for quantitative analysis of peptides and proteins

  Y Kuroda; H Yukinaga; M Kitano; T Noguchi; M Nemati; A Shibukawa; T Nakagawa; K Matsuzaki

  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Mar. 2005, Peer-reviewed

  
• Inhibitors of amyloid beta protein aggregation mediated by ganglioside cluster

  T Noguchi; M Wakabayashi; Y Ohashi; K Ikeda; T Okada; H Naiki; K Matsuzaki

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2005, Peer-reviewed

  
• Membrane translocation mechanism of the antimicrobial peptide buforin 2

  S Kobayashi; A Chikushi; S Tougu; Y Imura; M Nishida; Y Yano; K Matsuzaki

  BIOCHEMISTRY, Dec. 2004, Peer-reviewed

  
• A pivotal role of ganglioside in aggregation of amyloid .BETA.-protein

  松崎勝巳; 柳沢勝彦

  蛋白質 核酸 酵素, 10 Nov. 2004, Peer-reviewed

  
• Interaction between amyloid beta-protein aggregates and membranes

  A Kakio; Y Yano; D Takai; Y Kuroda; O Matsumoto; Y Kozutsumi; K Matsuzaki

  JOURNAL OF PEPTIDE SCIENCE, Oct. 2004, Peer-reviewed

  
• Role of positional hydrophobicity in the leishmanicidal activity of magainin 2

  E Guerrero; JM Saugar; K Matsuzaki; L Rivas

  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Aug. 2004, Peer-reviewed

  
• Environment- and mutation-dependent aggregation behavior of Alzheimer amyloid beta-protein

  N Yamamoto; K Hasegawa; K Matsuzaki; H Naiki; K Yanagisawa

  JOURNAL OF NEUROCHEMISTRY, Jul. 2004, Peer-reviewed

  
• A seed for Alzheimer amyloid in the brain

  H Hayashi; N Kimura; H Yamaguchi; K Hasegawa; T Yokoseki; M Shibata; N Yamamoto; M Michikawa; Y Yoshikawa; K Terao; K Matsuzaki; CA Lemere; DJ Selkoe; H Naiki; K Yanagisawa

  JOURNAL OF NEUROSCIENCE, May 2004, Peer-reviewed

  
• 膜におけるAβ重合開始の機構

  松﨑 勝巳

  Molecular Medicine,41, 416-419, 2004, Peer-reviewed

  
• ラフト構造とβアミロイド線維形成

  松﨑 勝巳

  Congnition and Dementia,3/4, 332-337, 2004, Peer-reviewed

  
• Facile synthesis of membrane-embedded peptides utilizing lipid bilayer-assisted chemical ligation

  A Otaka; S Ueda; K Tomita; Y Yano; H Tamamura; K Matsuzaki; N Fujii

  CHEMICAL COMMUNICATIONS, 2004, Peer-reviewed

  
• Measurement of thermodynamic parameters associated with intervesicular transfer of a transmembrane helix

  M Ogura; Y Yano; K Matsuzaki

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2004, Peer-reviewed

  
• Lipid membrane translocation mechanism of the antimicrobial peptide buforin 2

  S Kobayashi; A Chikushi; S Tougu; Y Imura; M Nishida; Y Yano; K Matsuzaki

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2004, Peer-reviewed

  
• Effects of PEGylation on the activity of tachyplesin I

  Y Imura; M Nishida; Y Ogawa; Y Takakura; K Matsuzaki

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2004, Peer-reviewed

  
• Synthesic Studies on 7TM-GPCR (I):Lipid Bilayer Assisted Membrane Peptide Ligation

  Satoshi Ueda; Kenji Tomita; Akira Otaka; Hirokazu Tamamura; Yoshiaki Yano; Katsumi Matsuzaki; Nobutaka Fujii

  Peptide Science 2003, 2004, Peer-reviewed

  
• Amyloid beta-protein (A beta)1-40 protects neurons from damage induced by A beta 1-42 in culture and in rat brain

  K Zou; D Kim; A Kakio; K Byun; JS Gong; J Kim; M Kim; N Sawamura; S Nishimoto; K Matsuzaki; B Lee; K Yanagisawa; M Michikawa

  JOURNAL OF NEUROCHEMISTRY, Nov. 2003, Peer-reviewed

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• Formation of a membrane-active form of amyloid beta-protein in raft-like model membranes

  A Kakio; SI Nishimoto; Y Kozutsumi; K Matsuzaki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2003, Peer-reviewed

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• Cinnamycin (Ro 09-0198) promotes cell binding and toxicity by inducing transbilayer lipid movement

  A Makino; T Baba; K Fujimoto; K Iwamoto; Y Yano; N Terada; S Ohno; SB Sato; A Ohta; M Umeda; K Matsuzaki; T Kobayashi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2003, Peer-reviewed

  
• Translocation of analogues of the antimicrobial peptides magainin and buforin across human cell membranes

  K Takeshima; A Chikushi; KK Lee; S Yonehara; K Matsuzaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2003, Peer-reviewed

  
• 膜タンパク質のフォールディング原理の解明： モデル膜貫通へリックスによるアプローチ

  松﨑 勝巳

  膜,28/ , 70-78, 2003, Peer-reviewed

  
• Elucidation of the Principles of Membrane Protein Folding Using Model Transmembrane Helices.

  Yano Yoshiaki; Matsuzaki Katsumi

  MEMBRANE, 2003

  
• Molecular mechanisms of initiation of amyloid .BETA. protein aggregation.

  松崎勝巳

  神経研究の進歩, 10 Dec. 2002, Peer-reviewed

  
• Membrane insertion and dissociation processes of a model transmembrane helix

  Y Yano; K Matsuzaki

  BIOCHEMISTRY, Oct. 2002, Peer-reviewed

  
• Dimer structure of magainin 2 bound to phospholipid vesicles

  K Wakamatsu; A Takeda; T Tachi; K Matsuzaki

  BIOPOLYMERS, Sep. 2002, Peer-reviewed

  
• Position-dependent hydrophobicity of the antimicrobial magainin peptide affects the mode of peptide-lipid interactions and selective toxicity

  T Tachi; RF Epand; RM Epand; K Matsuzaki

  BIOCHEMISTRY, Aug. 2002, Peer-reviewed

  
• Interactions of amyloid beta-protein with various gangliosides in raft-like membranes: Importance of GM1 ganglioside-bound form as an endogenous seed for Alzheimer amyloid

  A Kakio; S Nishimoto; K Yanagisawa; Y Kozutsumi; K Matsuzaki

  BIOCHEMISTRY, Jun. 2002, Peer-reviewed

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• Specific interactions of the antimicrobial peptide cyclic beta-sheet tachyplesin I with lipopolysaccharides

  Y Hirakura; S Kobayashi; K Matsuzaki

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, May 2002, Peer-reviewed

  
• Topological stability and self-association of a completely hydrophobic model transmembrane helix in lipid bilayers

  Y Yano; T Takemoto; S Kobayashi; H Yasui; H Sakurai; W Ohashi; M Niwa; S Futaki; Y Sugiura; K Matsuzaki

  BIOCHEMISTRY, Mar. 2002, Peer-reviewed

  
• Translocation of Basic Peptides through Human Cell Membranes

  K. Takeshima; A. Chikushi; S Kobayashi; L. Kyung-Kwon; S Yonehara; Akira Otaka; Nobutaka Fujii; K Matsuzaki

  Peptide Science 2001, 01 Mar. 2002, Peer-reviewed

  
• Cholesterol-dependent aggregation of amyloid beta-protein

  K Yanagisawa; K Matsuzaki

  ALZHEIMER'S DISEASE: VASCULAR ETIOLOGY AND PATHOLOGY, 2002, Peer-reviewed

  
• アミロイドβ蛋白質とガングリオシドの相互作用

  松﨑 勝巳

  蛋白質核酸酵素増刊号 生体膜のラフト形成と細胞のシグナリング（五十嵐靖之ほか編）,47/,351-356, 2002, Peer-reviewed

  
• アミロイドβ昼白の凝集開始の分子機能

  松﨑 勝巳

  神経研究の進歩,46/ , 813-817, 2002, Peer-reviewed

  
• Amyloidogenesis and cholesterol

  K Yanagisawa; K Matsuzaki

  MAPPING THE PROGRESS OF ALZHEIMER'S AND PARKINSON'S DISEASE, 2002, Peer-reviewed

  
• Bacteria-selective synergism between the antimicrobial peptides alpha-helical magainin 2 and cyclic beta-sheet tachyplesin I: Toward cocktail therapy

  S Kobayashi; Y Hirakura; K Matsuzaki

  BIOCHEMISTRY, Dec. 2001, Peer-reviewed

  
• Heterodimer formation between the antimicrobial peptides magainin 2 and PGLa in lipid bilayers: A cross-linking study

  T Hara; Y Mitani; K Tanaka; N Uematsu; A Takakura; T Tachi; H Kodama; M Kondo; H Mori; A Otaka; F Nobutaka; K Matsuzaki

  BIOCHEMISTRY, Oct. 2001, Peer-reviewed

  
• Why and how are peptide-lipid interactions utilized for self defence?

  K Matsuzaki

  BIOCHEMICAL SOCIETY TRANSACTIONS, Aug. 2001, Peer-reviewed

  
• Cholesterol-dependent formation of GM1 ganglioside-bound amyloid beta-protein, an endogenous seed for Alzheimer amyloid

  A Kakio; S Nishimoto; K Yanagisawa; Y Kozutsumi; K Matsuzaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2001, Peer-reviewed

  
• Effects of peptide dimerization on pore formation: Antiparallel disulfide-dimerized magainin 2 analogue

  T Hara; H Kodama; M Kondo; K Wakamatsu; A Takeda; T Tachi; K Matsuzaki

  BIOPOLYMERS, Apr. 2001, Peer-reviewed

  
• 抗菌性生体防御ペプチド 作用機構とその応用

  松崎勝巳

  Foods & Food Ingred J Jpn, 01 Jan. 2001, Peer-reviewed

  
• Polar angle as a determinant of amphipathic alpha-helix-lipid interactions: A model peptide study

  N Uematsu; K Matsuzaki

  BIOPHYSICAL JOURNAL, Oct. 2000, Peer-reviewed

  
• Optical characterization of liposomes by right angle light scattering and turbidity measurement

  K Matsuzaki; O Murase; K Sugishita; S Yoneyama; K Akada; M Ueha; A Nakamura; S Kobayashi

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Jul. 2000, Peer-reviewed

  
• Interactions of the novel antimicrobial peptide buforin 2 with lipid bilayers: Proline as a translocation promoting factor

  S Kobayashi; K Takeshima; CB Park; SC Kim; K Matsuzaki

  BIOCHEMISTRY, Jul. 2000, Peer-reviewed

  
• Structure-activity analysis of buforin II, a histone H2A-derived antimicrobial peptide: The proline hinge is responsible for the cell-penetrating ability of buforin II

  CB Park; KS Yi; K Matsuzaki; MS Kim; SC Kim

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jul. 2000, Peer-reviewed

  
• 脂質膜中での生体防御ぺプチド間のヘテロ分子認識に基づく高活性超分子形成

  松﨑 勝巳

  薬学研究の進歩,16/,109-115, 2000, Peer-reviewed

  
• GM1ガングリオシド結合型Aβ-その形成機構と病的意義

  松﨑 勝巳

  最新医学,55/,1596-1600, 2000, Peer-reviewed

  
• 抗菌性ペプチドbuforin2と脂質膜との相互作用

  松﨑 勝巳

  膜,25/,168-170, 2000, Peer-reviewed

  
• Why and how are peptide-lipid interactions utilized for self-defense? Magainins and tachyplesins as archetypes

  K Matsuzaki

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Dec. 1999, Peer-reviewed

  
• Interactions of an antimicrobial peptide, magainin 2, with lipopolysaccharide-containing liposomes as a model for outer membranes of Gram-negative bacteria

  K Matsuzaki; K Sugishita; K Miyajima

  FEBS LETTERS, Apr. 1999, Peer-reviewed

  
• Interactions of amyloid beta-peptide (1-40) with ganglioside-containing membranes

  K Matsuzaki; C Horikiri

  BIOCHEMISTRY, Mar. 1999, Peer-reviewed

  
• Synergism of antimicrobial peptides, magainin 2 and PGLa, in liposomes

  Y Mitani; K Tanaka; K Akada; K Miyajima; N Fujii; M Zasloff; K Matsuzaki

  PEPTIDE SCIENCE - PRESENT AND FUTURE, 1999, Peer-reviewed

  
• Magainins as paradigm for the mode of action of pore forming polypeptides

  K Matsuzaki

  BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON BIOMEMBRANES, Nov. 1998, Peer-reviewed

  
• Molecular assembly. Application and development. Supramolecular composites formation in lipid membranes of biophylaxis peptide.

  松崎勝巳

  化学工業, Nov. 1998, Peer-reviewed

  
• Mechanism of synergism between antimicrobial peptides magainin 2 and PGLa

  K Matsuzaki; Y Mitani; K Akada; O Murase; S Yoneyama; M Zasloff; K Miyajima

  BIOCHEMISTRY, Oct. 1998, Peer-reviewed

  
• Relationship of membrane curvature to the formation of pores by magainin 2

  K Matsuzaki; K Sugishita; N Ishibe; M Ueha; S Nakata; K Miyajima; RM Epand

  BIOCHEMISTRY, Aug. 1998, Peer-reviewed

  
• Interactions of self-defense pepides with membranes

  MATSUZAKI Katsumi

  Seibutsu Butsuri, 25 Sep. 1997, Peer-reviewed

  
• Membrane permeabilization mechanisms of a cyclic antimicrobial peptide, tachyplesin I, and its linear analog

  K Matsuzaki; S Yoneyama; N Fujii; K Miyajima; K Yamada; Y Kirino; K Anzai

  BIOCHEMISTRY, Aug. 1997, Peer-reviewed

  
• Pore formation and translocation of melittin

  K Matsuzaki; S Yoneyama; K Miyajima

  BIOPHYSICAL JOURNAL, Aug. 1997, Peer-reviewed

  
• Interactions of an antimicrobial peptide, magainin 2, with outer and inner membranes of Gram-negative bacteria

  K Matsuzaki; K Sugishita; M Harada; N Fujii; K Miyajima

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Jul. 1997, Peer-reviewed

  
• Molecular action mechanisms and membrane recognition of membrane-acting antimicrobial peptides

  K Matsuzaki

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, May 1997, Peer-reviewed

  
• Modulation of magainin 2-lipid bilayer interactions by peptide charge

  K Matsuzaki; A Nakamura; O Murase; K Sugishita; N Fujii; K Miyajima

  BIOCHEMISTRY, Feb. 1997, Peer-reviewed

  
• Coupled transbilayer transport of peptides, lipids, and ions mediated by a peptide-lipid supramolecular complex pore

  K Matsuzaki; K Miyajima

  SEIKAGAKU, Feb. 1997, Peer-reviewed

  
• 膜作動性抗菌ペプチドの新しい作用機構:ペプチド-脂質超分子複合体ポア形成

  松﨑 勝巳

  ファルマシア,33/,853, 1997, Peer-reviewed

  
• ペプチドー脂質超分子複合体ポアによるペプチド・脂質・イオンのcoupled transbilayer transport

  松﨑 勝巳

  生化学,69/2,119, 1997, Peer-reviewed

  
• Peptide helicity and membrane surface charge modulate the balance of electrostatic and hydrophobic interactions with lipid bilayers and biological membranes

  M Dathe; M Schumann; T Wieprecht; A Winkler; M Beyermann; E Krause; K Matsuzaki; O Murase; M Bienert

  BIOCHEMISTRY, Sep. 1996, Peer-reviewed

  
• An antimicrobial peptide, magainin 2, induced rapid flip-flop of phospholipids coupled with pore formation and peptide translocation

  K Matsuzaki; O Murase; N Fujii; K Miyajima

  BIOCHEMISTRY, Sep. 1996, Peer-reviewed

  
• Transbilayer transport of ions and lipids coupled with mastoparan X translocation

  K Matsuzaki; S Yoneyama; O Murase; K Miyajima

  BIOCHEMISTRY, Jun. 1996, Peer-reviewed

  
• Action mechanism of a membrane-acting peptide, melittin: Translocation of peptides across lipid membranes

  K Matsuzaki; S Yoneyama; K Miyajima

  PEPTIDE CHEMISTRY 1995, 1996, Peer-reviewed

  
• KINETICS OF PORE FORMATION BY AN ANTIMICROBIAL PEPTIDE, MAGAININ-2, IN PHOSPHOLIPID-BILAYERS

  K MATSUZAKI; O MURASE; K MIYAJIMA

  BIOCHEMISTRY, Oct. 1995, Peer-reviewed

  
• TRANSLOCATION OF A CHANNEL-FORMING ANTIMICROBIAL PEPTIDE, MAGAININ-2, ACROSS LIPID BILAYERS BY FORMING A PORE

  K MATSUZAKI; O MURASE; N FUJII; K MIYAJIMA

  BIOCHEMISTRY, May 1995, Peer-reviewed

  
• MOLECULAR-BASIS FOR MEMBRANE SELECTIVITY OF AN ANTIMICROBIAL PEPTIDE, MAGAININ-2

  K MATSUZAKI; K SUGISHITA; N FUJII; K MIYAJIMA

  BIOCHEMISTRY, Mar. 1995, Peer-reviewed

  
• A NOVEL MECHANISM OF MEMBRANE-ACTING ANTIMICROBIAL PEPTIDES - TRANSLOCATION OF PEPTIDES THROUGH LIPID MEMBRANES

  K MATSUZAKI; S YONEYAMA; O MURASE; N FUJII; K MIYAJIMA

  PEPTIDE CHEMISTRY 1994, 1995, Peer-reviewed

  
• MOLECULAR-PARAMETERS FOR THE ANTI-HUMAN-IMMUNODEFICIENCY-VIRUS ACTIVITY OF T22 ([TYR(5,12),LYS(7)]-POLYPHEMUSIN-II)

  A OTAKA; H TAMAMURA; Y TERAKAWA; M MASUDA; T KODE; T MURAKAMI; H NAKASHIMA; K MATSUZAKI; K MIYAJIMA; T IBUKA; M WAKI; A MATSUMOTO; N YAMAMOTO; N FUJII

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Dec. 1994, Peer-reviewed

  
• EFFECTS OF ABSORPTION ENHANCERS AND LIPID-COMPOSITION ON DRUG PERMEABILITY THROUGH THE MODEL MEMBRANE USING STRATUM-CORNEUM LIPIDS

  K MIYAJIMA; S TANIKAWA; M ASANO; K MATSUZAKI

  CHEMICAL & PHARMACEUTICAL BULLETIN, Jun. 1994, Peer-reviewed

  
• ORIENTATIONAL AND AGGREGATIONAL STATES OF MAGAININ-2 IN PHOSPHOLIPID-BILAYERS

  K MATSUZAKI; O MURASE; H TOKUDA; S FUNAKOSHI; N FUJII; K MIYAJIMA

  BIOCHEMISTRY, Mar. 1994, Peer-reviewed

  
• STRUCTURE-ACTIVITY-RELATIONSHIPS OF T22 ([TYR(5,12), LYS(7)]-POLYPHEMUSIN-II) AS AN ANTI-HIV AGENT

  Y TERAKAWA; H TAMAMURA; A OTAKA; M MASUDA; T KOIDE; K MATSUZAKI; M KURODA; K MIYAJIMA; N FUJII; H NAKASHIMA; Y OSHIRO; N YAMAMOTO; M WAKI; A MATSUMOTO

  PEPTIDE CHEMISTRY 1993, 1994, Peer-reviewed

  
• ROLE OF DISULFIDE LINKAGES IN TACHYPLESIN LIPID INTERACTIONS

  K MATSUZAKI; M NAKAYAMA; M FUKUI; A OTAKA; S FUNAKOSHI; N FUJII; K BESSHO; K MIYAJIMA

  BIOCHEMISTRY, Nov. 1993, Peer-reviewed

  
• PERMEABILIZATION AND MORPHOLOGICAL-CHANGES IN PHOSPHATIDYLGLYCEROL BILAYERS INDUCED BY AN ANTIMICROBIAL PEPTIDE, TACHYPLESIN-I

  K MATSUZAKI; M FUKUI; N FUJII; K MIYAJIMA

  COLLOID AND POLYMER SCIENCE, Sep. 1993, Peer-reviewed

  
• DEVELOPMENT OF A MODEL MEMBRANE SYSTEM USING STRATUM-CORNEUM LIPIDS FOR ESTIMATION OF DRUG SKIN PERMEABILITY

  K MATSUZAKI; T IMAOKA; M ASANO; K MIYAJIMA

  CHEMICAL & PHARMACEUTICAL BULLETIN, Mar. 1993, Peer-reviewed

  
• INTERACTIONS OF C-TERMINAL TRUNCATED MAGAININ-2 WITH LIPID-MEMBRANES

  K MATSUZAKI; O MURASE; S FUNAKOSHI; N FUJII; K MIYAJIMA

  PEPTIDE CHEMISTRY 1992, 1993, Peer-reviewed

  
• ORIENTATION AND AGGREGATION OF MAGAININ IN LIPID BILAYERS

  K MATSUZAKI; O MURASE; H TOKUDA; S FUNAKOSHI; N FUJII; K MIYAJIMA

  PEPTIDE CHEMISTRY 1992, 1993, Peer-reviewed

  
• EFFECTS OF MEMBRANE CHARGE AND TRANSMEMBRANE POTENTIAL ON THE INTERACTIONS OF BETA-SHEET PEPTIDES (TACHYPLESIN-I, DEFENSIN, GRAMICIDIN-S) WITH LIPID BILAYERS

  K MATSUZAKI; M KOMORI; M FUKUI; S FUNAKOSHI; N FUJII; K MIYAJIMA

  PEPTIDE CHEMISTRY 1992, 1993, Peer-reviewed

  
• 脂質膜とペプチドとの相互作用に関する分子論的考察

  松崎勝巳

  膜, Nov. 1992, Peer-reviewed

  
• INTERACTIONS OF TRP-SUBSTITUTED MAGAININS WITH LIPID BILAYERS

  K MATSUZAKI; O MURASE; H TOKUDA; S FUNAKOSHI; N FUJII; K MIYAJIMA

  PEPTIDE CHEMISTRY 1991, 1992, Peer-reviewed

  
• A comparative study on interactions of α-aminoisobutyric acid containing antibiotic peptides, trichopolyn I and hypelcin A with phosphatidylcholine bilayers

  Katsumi Matsuzaki; Takahide Shioyama; Emiko Okamura; Junzo Umemura; Tohru Takenaka; Yoshihisa Takaishi; Teturo Fujita; Koichiro Miyajima

  BBA - Biomembranes, 09 Dec. 1991, Peer-reviewed

  
• A COMPARATIVE-STUDY ON INTERACTIONS OF ALPHA-AMINOISOBUTYRIC-ACID CONTAINING ANTIBIOTIC PEPTIDES, TRICHOPOLYN-I AND HYPELCIN-A WITH PHOSPHATIDYLCHOLINE BILAYERS

  K MATSUZAKI; T SHIOYAMA; E OKAMURA; J UMEMURA; T TAKENAKA; Y TAKAISHI; T FUJITA; K MIYAJIMA

  BIOCHIMICA ET BIOPHYSICA ACTA, Dec. 1991, Peer-reviewed

  
• A COMPARATIVE-STUDY ON INTERACTIONS OF ALPHA-AMINOISOBUTYRIC-ACID CONTAINING ANTIBIOTIC PEPTIDES, TRICHOPOLYN-I AND HYPELCIN-A WITH PHOSPHATIDYLCHOLINE BILAYERS

  K MATSUZAKI; T SHIOYAMA; E OKAMURA; J UMEMURA; T TAKENAKA; Y TAKAISHI; T FUJITA; K MIYAJIMA

  BIOCHIMICA ET BIOPHYSICA ACTA, Dec. 1991, Peer-reviewed

  
• Interactions of an antimicrobial peptide, tachyplesin I, with lipid membranes

  Katsumi Matsuzaki; Masaru Fukui; Nobutaka Fujii; Koichiro Miyajima

  BBA - Biomembranes, 18 Nov. 1991, Peer-reviewed

  
• INTERACTIONS OF AN ANTIMICROBIAL PEPTIDE, TACHYPLESIN-I, WITH LIPID-MEMBRANES

  K MATSUZAKI; M FUKUI; N FUJII; K MIYAJIMA

  BIOCHIMICA ET BIOPHYSICA ACTA, Nov. 1991, Peer-reviewed

  
• INTERACTIONS OF AN ANTIMICROBIAL PEPTIDE, TACHYPLESIN-I, WITH LIPID-MEMBRANES

  K MATSUZAKI; M FUKUI; N FUJII; K MIYAJIMA

  BIOCHIMICA ET BIOPHYSICA ACTA, Nov. 1991, Peer-reviewed

  
• HYPELCIN A, AN ALPHA-AMINOISOBUTYRIC-ACID CONTAINING ANTIBIOTIC PEPTIDE, INDUCED FUSION OF EGG YOLK-L-ALPHA-PHOSPHATIDYLCHOLINE SMALL UNILAMELLAR VESICLES

  K MATSUZAKI; Y TAKAISHI; T FUJITA; K MIYAJIMA

  COLLOID AND POLYMER SCIENCE, Jun. 1991, Peer-reviewed

  
• HYPELCIN A, AN ALPHA-AMINOISOBUTYRIC-ACID CONTAINING ANTIBIOTIC PEPTIDE, INDUCED FUSION OF EGG YOLK-L-ALPHA-PHOSPHATIDYLCHOLINE SMALL UNILAMELLAR VESICLES

  K MATSUZAKI; Y TAKAISHI; T FUJITA; K MIYAJIMA

  COLLOID AND POLYMER SCIENCE, Jun. 1991, Peer-reviewed

  
• Physicochemical determinants for the interactions of magainins 1 and 2 with acidic lipid bilayers

  Katsumi Matsuzaki; Mitsunori Harada; Susumu Funakoshi; Nobutaka Fujii; Koichiro Miyajima

  BBA - Biomembranes, 18 Mar. 1991, Peer-reviewed

  
• PHYSICOCHEMICAL DETERMINANTS FOR THE INTERACTIONS OF MAGAININS-1 AND MAGAININS-2 WITH ACIDIC LIPID BILAYERS

  K MATSUZAKI; M HARADA; S FUNAKOSHI; N FUJII; K MIYAJIMA

  BIOCHIMICA ET BIOPHYSICA ACTA, Mar. 1991, Peer-reviewed

  
• INTERACTIONS OF ANTIMICROBIAL PEPTIDES, MAGAININS, WITH ACIDIC LIPID BILAYERS

  K MATSUZAKI; M HARADA; S FUNAKOSHI; N FUJII; K MIYAJIMA

  PEPTIDE CHEMISTRY 1990, 1991, Peer-reviewed

  
• HYPELCIN-A, AN ALPHA-AMINOISOBUTYRIC-ACID CONTAINING ANTIBIOTIC PEPTIDE, INDUCED PERMEABILITY CHANGE OF PHOSPHATIDYLCHOLINE BILAYERS

  K MATSUZAKI; S NAKAI; T HANDA; Y TAKAISHI; T FUJITA; K MIYAJIMA

  BIOCHEMISTRY, Nov. 1989, Peer-reviewed

  
• Magainin 1-induced leakage of entrapped calcein out of negatively-charged lipid vesicles

  Katsumi Matsuzaki; Mitsunori Harada; Tetsurou Handa; Susumu Funakoshi; Nobutaka Fujii; Haruaki Yajima; Koichiro Miyajima

  BBA - Biomembranes, 19 May 1989, Peer-reviewed

  
• MAGAININ 1-INDUCED LEAKAGE OF ENTRAPPED CALCEIN OUT OF NEGATIVELY-CHARGED LIPID VESICLES

  K MATSUZAKI; M HARADA; T HANDA; S FUNAKOSHI; N FUJII; H YAJIMA; K MIYAJIMA

  BIOCHIMICA ET BIOPHYSICA ACTA, May 1989, Peer-reviewed

  
• A fluorescent probing study on microenvironments in bile salt micelles and bile salt/phosphatidylcholine mixtures in the absence or presence of cholesterol

  Katsumi Matsuzaki; Isao Yokoyama; Hiroaki Komatsu; Tetsurou Handa; Koichiro Miyajima

  BBA - Biomembranes, 28 Apr. 1989, Peer-reviewed

  
• A FLUORESCENT PROBING STUDY ON MICROENVIRONMENTS IN BILE-SALT MICELLES AND BILE-SALT PHOSPHATIDYLCHOLINE MIXTURES IN THE ABSENCE OR PRESENCE OF CHOLESTEROL

  K MATSUZAKI; YOKOYAMA, I; H KOMATSU; T HANDA; K MIYAJIMA

  BIOCHIMICA ET BIOPHYSICA ACTA, Apr. 1989, Peer-reviewed

  
• QUANTITATIVE-ANALYSIS OF HEMOLYTIC ACTION OF LYSOPHOSPHATIDYLCHOLINES INVITRO - EFFECT OF ACYL CHAIN STRUCTURE

  K MATSUZAKI; T HANDA; K MIYAJIMA; Y MIKURA; H SHIMIZU; H TOGUCHI

  CHEMICAL & PHARMACEUTICAL BULLETIN, Nov. 1988, Peer-reviewed

  
• ORIENTATIONS OF A BIFUNCTIONAL MOLECULE, 16-(9-ANTHROYLOXY)PALMITIC ACID, IN MICELLES AND LIPOSOMES

  T HANDA; K MATSUZAKI; M NAKAGAKI

  JOURNAL OF COLLOID AND INTERFACE SCIENCE, Mar. 1987, Peer-reviewed

  
• Mobility of fluorescent probe molecules in lipid bilayer vesicles as studied by steady-state and time-dependent nuclear Overhauser effect measurements in 1H-nuclear magnetic resonance spectroscopy

  Yoshihiro Kuroda; Katsumi Matsuzaki; Tetsurou Handa; Masayuki Nakagaki

  BBA - Biomembranes, 24 Jul. 1986, Peer-reviewed

  
• MOBILITY OF FLUORESCENT-PROBE MOLECULES IN LIPID BILAYER VESICLES AS STUDIED BY STEADY-STATE AND TIME-DEPENDENT NUCLEAR OVERHAUSER EFFECT MEASUREMENTS IN H-1-NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY

  Y KURODA; K MATSUZAKI; T HANDA; M NAKAGAKI

  BIOCHIMICA ET BIOPHYSICA ACTA, Jul. 1986, Peer-reviewed

  
• Effects of Microenvironment on the Fluorescence Yields of Dialkyl-thiacarbocyanines as Sensitizers in Photochemical Reactions

  Tetsurou Handa; Hiroaki Komatsu; Katsumi Matsuzaki; Masayuki Nakagaki

  Nippon Kagaku Kaishi, 1984, Peer-reviewed

  
• EFFECTS OF MICROENVIRONMENT ON THE FLUORESCENCE YIELDS OF DIALKYLTHIACARBOCYANINES AS SENSITIZERS IN PHOTOCHEMICAL-REACTIONS

  T HANDA; H KOMATSU; K MATSUZAKI; M NAKAGAKI

  NIPPON KAGAKU KAISHI, 1984, Peer-reviewed

  

Misc.

• O-アシルイソペプチド法を基盤としたPhoto-Triggered“Click Peptide”の開発:Chemical Biologyを指向した新規Aβ1-42アナログの創製

  谷口敦彦; 相馬洋平; 木村麻衣子; 岡田琢磨; 池田恵介; 林良雄; 木村徹; 広田俊; 広田俊; 松崎勝巳; 木曽良明

  日本薬学会年会要旨集, 2006

  
• ガングリオシドクラスターを介したアミロイドβタンパク質(Aβ)の凝集:Aβ-(1-40)とAβ-(1-42)の比較

  小川麻里子; 佃実保; 山口貴宏; 池田恵介; 岡田琢磨; 矢野義明; 星野大; 松崎勝巳

  生体膜と薬物の相互作用シンポジウム講演要旨集, 2010

  
• Click peptide:アルツハイマー病関連アミロイドβペプチドを産生する水溶性プレカーサーアナログ

  谷口敦彦; 相馬洋平; 相馬洋平; SKWARCZYNSKI Mariusz; SKWARCZYNSKI Mariusz; 平山雄太; 岡田琢磨; 池田恵介; PRAKASH Halan; 向井秀仁; 木村徹; 林良雄; 林良雄; 廣田俊; 松崎勝巳; 木曽良明

  日本薬学会年会要旨集, 2009

  
• ラフト様脂質膜存在下で形成されたアミロイドβ蛋白質線維の構造解析

  池田恵介; 矢野義明; 星野大; 松崎勝巳

  日本薬学会年会要旨集, 2006

  
• Formation of Toxic Fibrils by Alzheimer's Amyloid-β on Neuronal Cell Membranes

  松﨑 勝巳

  化學工業, Nov. 2014

  
• Control of Antimicrobial Peptide Target by Introducing Proline and Positive Charges

  CHODA Naoki; IMURA Yuichi; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2009

  
• 3Fa05 Antimicrobial mechanism of lacticin Q, a bacteriocin from lactic acid bacteria

  YONEYAMA Fuminori; IMURA Yuichi; OHNO Kanako; ZENDO Takeshi; NAKAYAMA Jiro; MATSUZAKI Katsumi; SONOMOTO Kenji

  日本生物工学会大会講演要旨集, 2008

  
• Aggregation of Alzheimer's Amyloid β-Protein in Lipid Rafts

  MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2007

  
• Action Mechanism of a PEGylated Magainin Analogue Peptide

  IMURA Yuichi; NISHIDA Minoru; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2006

  
• Modulation of Magainin 2-Lipid Bilayer Interactions by Peptide Charge

  MATSUZAKI Katsumi; NAKAMURA Akemi; MURASE Osamu; SUGISHITA Ken-ichi; FUJII Nobutaka; MIYAJIMA Koichiro

  Peptide chemistry : proceedings of the ... Symposium on Peptide Chemistry, 01 Oct. 1996

  
• アラメチシンにおける電位依存性チャンネルのゲーティング機構

  松崎 勝巳

  ファルマシア, 01 Jan. 1993

  
• Association-dissociation kinetics for dimerization of transmembrane helices as detected by single molecule fluorescence spectroscopy

  YANO Yoshiaki; KITANI Ryota; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011

  
• Internalization and oligomerization of membrane receptors in living cells as detected by novel coiled-coil fluorescence labeling methods

  MATSUZAKI Katsumi; OMAE Kaoru; YANO Yoshiaki

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011

  
• Elucidation of Membrane Protein Folding Using Model Transmembrane Helices

  YANO Yoshiaki; OGURA Mai; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2007

  
• "Click Peptide" : the "O-Acyl Isopeptide Method" for Peptide Synthesis and Development of Chemical Biology-Oriented Aβ Analogues

  TANIGUCHI Atsuhiko; SOHMA Youhei; YOSHIYA Taku; FUKAO Fukue; NAKAMURA Setsuko; CHIYOMORI Yousuke; HAYASHI Yoshio; KIMURA Tooru; HIROTA Shun; MATSUZAKI Katsumi; KISO Yoshiaki

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2007

  
• アミロイドβ蛋白質重合とガングリオシド (神経糖鎖生物学) -- (糖鎖と神経・筋疾患,病態モデル)

  松崎 勝巳; 柳澤 勝彦

  蛋白質核酸酵素, Nov. 2004

  
• Visualizing Internalization of Membrane Receptors Using New Fluorescence Labeling Method

  YANO Yoshiaki; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2009

  
• Click Peptide by Use of the O-Acyl Isopeptide Method : Production of Amyloid β Peptide from Water-Soluble Analogue

  TANIGUCHI Atsuhiko; SOHMA Youhei; SKWARCZYNSKI Mariusz; OKADA Takuma; IEDA Keisuke; PRAKASH Halan; MUKAI Hidehito; KIMURA Tooru; HAYASHI Yoshio; HIROTA Shun; MATSUZAKI Katsumi; KISO Yoshiaki

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2009

  
• 水溶液中とラフト様脂質膜中で形成されるアミロイドβタンパク質凝集体の比較 (第25回生体膜と薬物の相互作用シンポジウム--ダイナミックインターフェイスとしての生体膜 講演要旨集)

  垣尾 敦子; 矢野 義明; 松崎 勝巳

  薬学雑誌, 13 Nov. 2003

  
• 膜貫通ヘリックスの脂質間移行熱力学量の計測 (第26回 生体膜と薬物の相互作用シンポジウム 講演要旨集)

  小倉 まい; 矢野 義明; 松崎 勝巳

  薬学雑誌, 25 Nov. 2004

  
• Stability and Self-Association of a Model Transmembrane Helix in Lipid Bilayers

  YANO Yoshiaki; TAKEMOTO Tomokazu; KOBAYASHI Satoe; OHASHI Wakana; NIWA Miki; FUTAKI Shiroh; SUGIURA Yukio; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2001

  
• Interaction between a Novel Antimicrobial Peptide Buforin 2 and Lipid Bilayers

  KOBAYASHI Satoe; TAKESHIMA Kenta; KIM Sun Chang; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2000

  
• Effects of Peptide Dimerization on Pore Formation : Antiparallel Disulfide-Dimerized Magainin 2 Analog

  HARA Toshiaki; KODAMA Hiroaki; KONDO Michio; WAKAMATSU Kaori; TAKEDA Akemi; TACHI Tomoya; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2001

  
• Interactions of a Membrane-Spanning Model Peptide with Lipid Bilayers

  MATSUZAKI Katsumi; TAKEMOTO Tomokazu; YANO Yoshiaki; KOBAYASHI Satoe

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2000

  
• Comparison between Amyloid beta-Protein Aggregates Formed in Aqueous Solution and Raft-like Membranes

  KAKIO Atsuko; YANO Yoshiaki; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2004

  
• Improvement of Probe Peptides for Coiled-Coil Labeling by Introducing Phosphoserines

  ONO Satoshi; YANO Yoshiaki; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2012

  
• Lipophobic Interaction : Lipid-Induced Association of Transmembrane Helices

  YANO Yoshiaki; YAMAMOTO Arisa; OGURA Mai; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2012

  
• Mechanism of Amyloid β-Protein Aggregation Mediated by GM1 Ganglioside Clusters

  MATSUZAKI Katsumi; IKEDA Keisuke; YAMAGUCHI Takahiro; FUKUNAGA Saori; HOSHINO Masaru

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2012

  
• Low-Polarity Environment is Important for the Formation of Toxic Amyloid β Aggregates

  FUKUNAGA Saori; YAMAGUCHI Takahiro; YANO Yoshiaki; HOSHINO Masaru; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2012

  
• GM1 Ganglioside-Mediated Accumulation of Amyloid β-Protein on Cell Membranes

  WAKABAYASHI Masaki; NOBUCHI Taeko; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2006

  
• Inhibition of Amyloid β Peptide Fibril Formation by Hydrogel Nanoparticles

  IKEDA Keisuke; SAWADA Shinichi; AKIYOSHI Kazunari; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2006

  
• Membrane-bound conformation of magainin 2

  Takeda A.; Wakamatsu K.; Matsuzaki K.

  Biophysics, 07 Sep. 1998

  
• Mechanism of synergism between antimicrobial peptides, magainin 2 and PGLa.

  Matsuzaki K.; Mitani Y.; Tanaka K.; Miyajima K.

  Biophysics, 07 Sep. 1998

  
• INTERACTIONS OF AN ANTIMICROBIAL PEPTIDE, TACHYPLESIN I, WITH LIPID MEMBRANES

  MATSUZAKI Katsumi; FUKUI Masaru; FUJII Nobutaka; MIYAJIMA Koichiro

  Journal of pharmacobio-dynamics, Mar. 1991

  
• アミロイドβ蛋白質とガングリオシドとの相互作用 (マイクロドメイン形成と細胞のシグナリング--スフィンゴ脂質の新しい生物機能) -- (第1部 膜ドメインと生物機能)

  松崎 勝巳

  蛋白質核酸酵素, Mar. 2002

  
• PEPTIDE-BASED LIPOSOME-CELL FUSION SYSTEM FOR CELLULAR DELIVERY OF LIPOSOMAL COMPONENTS

  N. Fukada; Y. Yano; K. Matsuzaki

  JOURNAL OF PEPTIDE SCIENCE, Sep. 2016

  
• The 3G Condiments, Garlic, Ginger, and Green Onion, Exhibit Synergistic Antibacterial effects

  望月 達人; 河野 健一; 矢野 義明; 松崎 勝巳

  ELCAS Journal, Mar. 2016

  Access this misc :

  
• Relationship between Aggregation of Amyloid-beta Protein on Cells and Cytotoxicity

  Naoya Itoh; Eri Takada; Yoshiaki Yano; Masaru Hoshino; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Feb. 2016

  
• Glutamine-rich activation domain of transcription factor Sp1-biochemical activity and structure

  Jun Kuwahara; Chisana Uwatoko; Emi Hibino; Katsumi Matsuzaki; Masaru Hoshino

  PROTEIN SCIENCE, Oct. 2015

  
• Identification of toxic A beta aggregates and cross seeding between A beta 40 and A beta 42 on neuronal cells

  N. Itoh; E. Takada; Y. Yano; M. Hoshino; K. Matsuzaki

  EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Jul. 2015

  
• The Presence of Antiparallel Beta-Sheets in Toxic Fibrils Formed by ABeta on GM1 Clusters

  Yuki Okada; Hiroshi Ueno; Yoshiaki Yano; Masaru Hoshino; Hikari Itoh-Watanabe; Akira Naito; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2015

  
• Single-Molecule FRET Detection of GXXXG-Mediated Transmembrane Helix-Helix Interactions

  Yoshiaki Yano; Kotaro Kondo; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2015

  
• The Amantadine-Resistant S31N Mutant of Influenza a Virus M2 Protein Stably Forms a Dimer on the Living Cells

  Kenichi Kawano; Yoshiaki Yano; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2014

  
• Dimer is a Minimal Functional Unit of Influenza a Virus M2 Channel on Living Cells

  Kenichi Kawano; Yoshiaki Yano; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2014

  
• Influenza A virus M2 protein forms a dimeric channel in biomembranes

  K. Kawano; Y. Yano; K. Matsuzaki

  EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Jul. 2013

  
• Detection of Oligomerization of Membrane Proteins using Coiled-Coil Tag-Probe Labeling Method and In-Cell Fluorescence Spectroscopy

  Kenichi Kawano; Kaoru Omae; Sayaka Matsuzaki; Yoshiaki Yano; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2013

  
• Interaction of Magainin 2 with Gangliosides as a Target for Human Cell Binding

  Yu Miyazaki; Yoshiaki Yano; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2013

  
• Oligomeric States of Full Length Influenza a Virus M2 Proteins on Biological Membranes

  Ken-ichi Kawano; Sayaka Matsuzaki; Kaoru Oomae; Yoshiaki Yano; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2013

  
• 膜タンパク質変性作用の少ない可溶化剤の開発

  HAYASHIDA KOICHI; MOGI YUZO; YAMAOKA YOSUKE; TAKASU KIYOSEI; YANO YOSHIAKI; MATSUZAKI KATSUMI

  日本薬学会年会要旨集(CD-ROM), 2013

  
• Association-Dissociation Dynamics of Transmembrane Helices as Detected by Single-Molecule Fluorescence Microscopy

  Yoshiaki Yano; Ryota Kitani; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2012

  
• 水素結合ドナー型有機触媒を用いたアルキノエートの異性化によるアレノエートの不斉合成

  宇野卓矢; 猪熊 翼; 古川雅也; 吉田耕三; 鈴木雄介; 矢野義明; 松崎勝巳; 竹本佳司

  第37回反応と合成の進歩シンポジウム, Nov. 2011, Peer-reviewed

  
• 新規水素結合ドナー型触媒の開発

  猪熊 翼; 古川雅也; 宇野卓矢; 鈴木雄介; 吉田耕三; 矢野義明; 松崎勝巳; 竹本佳司

  第61回日本薬学会近畿支部大会, Oct. 2011, Peer-reviewed

  
• Mechanism of amyloid formation by A beta in raft-like membranes containing ganglioside clusters

  Keisuke Ikeda; Takahiro Yamaguchi; Saori Fukunaga; Masaru Hoshino; Katsumi Matsuzaki

  EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Aug. 2011

  
• Synthesis and Application of Fluorescent SDF-1 Derivatives

  Ryo Masuda; Shinya Oishi; Noriko Tanahara; Hiroaki Ohno; Akira Hirasawa; Gozoh Tsujimoto; Yoshiaki Yano; Katsumi Matsuzaki; Nobutaka Fujii

  BIOPOLYMERS, 2011

  
• 蛍光標識CXCR4受容体リガンドの創製と応用

  MASUDA RYO; OISHI SHIN'YA; TANAHARA NORIKO; ONO HIROAKI; HIRASAWA AKIRA; TSUJIMOTO GOZO; YANO YOSHIAKI; MATSUZAKI KATSUMI; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 18 Oct. 2010

  
• A novel EGFR-targeted hybrid peptide can overcome the resistance of cancer cells to tyrosine kinase inhibitors

  河野 雅之; 堀部 智久; 矢野 良昭; 松崎 勝巳; 川上 浩司

  「第69回日本癌学会学術総会」 2010年9月22－24日, 大阪., Sep. 2010

  
• Oligomerization of Membrane Receptors: FRET Analysis Using Coiled-Coil Tag-Probe Labeling and Spectral Imaging

  Yoshiaki Yano; Kaoru Omae; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2010

  
• Roles of Lys and Arg in the Activity of Antimicrobial Peptides

  Naoki Choda; Yoshiaki Yano; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2010

  
• 新規EGF受容体標的化ハイブリッドペプチドの発見と癌細胞死メカニズムの探索

  河野 雅之; 堀部 智久; 原本 真理; 矢野 義明; 中島 央美; 松崎 勝巳; 川上 浩司

  「第46回ペプチド討論会（日本ペプチド学会）」. 2009年11月5日、北九州., Nov. 2009

  
• Click peptide: In situ production of Alzheimer's disease-related amyloid beta peptide from water-soluble precursor analogs

  Atsuhiko Taniguchi; Youhei Sohma; Mariusz Skwarczynski; Yuta Hirayama; Takuma Okada; Keisuke Ikeda; Halan Prakash; Hidehito Mukai; Tooru Kimura; Yoshio Hayashi; Shun Hirota; Katsumi Matsuzaki; Yoshiaki Kiso

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2009

  
• "CLICK PEPTIDE" BASED ON "O-ACYL ISOPEPTIDE METHOD": IN SITU PRODUCTION OF MONOMER AMYLOID beta PEPTIDE FROM WATER-SOLUBLE PRECURSOR ANALOGUES

  A. Taniguchi; Y. Sohma; M. Skwarczynski; Y. Hirayama; T. Okada; K. Ikeda; H. Prakash; H. Mukai; T. Kimura; Y. Hayashi; S. Hirota; K. Matsuzaki; Y. Kiso

  BIOPOLYMERS, 2009

  
• 新規生細胞膜受容体蛍光ラベル法:コイルドコイルタグ‐プローブペア

  YANO YOSHIAKI; YANO AKIKO; OISHI SHIN'YA; SUGIMOTO YUKIHIKO; TSUJIMOTO GOZO; FUJII NOBUTAKA; MATSUZAKI KATSUMI

  日本薬学会年会要旨集, 05 Mar. 2008

  
• Specific Fluorescence Labeling of Membrane Receptors in Living Cells using Coiled-coil Tag

  YANO Yoshiaki; YANO Akiko; OISHI Shinya; SUGIMOTO Yukihiko; TSUJIMOTO Gozoh; FUJII Nobutaka; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2008

  
• Properties of Intracellular Fragment Peptides of Mouse Prostaglandin E_2 Receptor EP3 Isoform

  SHIMBO Takuya; YANO Yoshiaki; OISHI Shinya; FUJII Nobutaka; SUGIMOTO Yukihiko; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2008

  
• Formation of Toxic Aβ-(1-40) Fibrils on GM1 Ganglioside-containing Membranes Mimicking Lipid Rafts

  OKADA Takuma; IKEDA Keisuke; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2008

  
• モデル膜貫通ヘリックスの膜への分配の熱力学に対する,脂質頭部の電荷,膜流動性,側方圧の影響

  矢野義明; 小倉まい; 吉村優一; 松崎勝巳

  日本薬学会年会要旨集, 05 Mar. 2007

  
• Interaction of magainin with living mammalian cells

  Yuichi Imura; Naoki Choda; Nobutaka Fujii; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2007

  
• Click peptide: Chemical biology-oriented synthesis of Alzheimer's amyloid beta peptide 1-42 analogues

  A. Taniguchi; Y. Sohma; M. Kimura; M. Skwarczynski; T. Nagano; T. Okada; K. Ikeda; Y. Hayashi; T. Kimura; S. Hirota; K. Matsuzaki; Y. Kiso

  BIOPOLYMERS, 2007

  
• Specific fluorescence labeling of membrane receptors in living cells using peptide-peptide interaction

  Yoshiaki Yano; Akiko Yano; Yukihiko Sugimoto; Katsumi Matsuzaki

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2007

  
• Effects of headgroup charge, lateral pressure, and rigidity of lipid bilayers on thermodynamics of membrane partitioning of a model transmembrane helix

  Yoshiaki Yano; Mai Ogura; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2007

  
• アミロイドーシス発症の分子機構解明を目指して：現状と展望，夢

  後藤 祐児; 桑田 一夫; 関島 良樹; 田中 元雅; 内木 宏延; 永井 義隆; 松崎 勝巳; 樋口 京一

  細胞工学, 2007

  
• "Click peptide": A novel "O-acyl isopeptide method" for peptide synthesis and chemical biology-oriented synthesis of Alzheimer's disease-related A beta analogues

  Y. Sohma; A. Taniguchi; Y. Chiyomori; F. Fukao; T. Yoshiya; M. Kimura; T. Okada; K. Ikeda; Y. Hayashi; T. Kimura; S. Hirota; K. Matsuzaki; Y. Kiso

  JOURNAL OF PEPTIDE SCIENCE, 2006

  
• Photo-triggered "click peptide" based on the "O-acyl isopeptide method": Controlled production of amyloid beta peptide (A beta) 1-42

  A. Taniguchi; Y. Sohma; M. Kimura; T. Okada; K. Ikeda; Y. Hayashi; T. Kimura; S. Hirota; K. Matsuzaki; Y. Kiso

  JOURNAL OF PEPTIDE SCIENCE, 2006

  
• Structural analysis of amyloid-ß protein fibrils formed in raft-like model membranes.

  Keisuke Ikeda; Yoshiaki Yano; Masaru Hoshino; Kazuhiro Hasegawa; Hironobu Naiki; Youhei Sohma; Yoshio Hayashi; Yoshiaki Kiso; Katsumi Matsuzaki

  Peptide Science 2006, 2006

  
• Inhibition of amyloid ß-protein Aß-(1-42) induced cytotoxicity by helical Aß analog.

  Miho Tsukuda; Takuma Okada; Masaki Wakabayashi; Youhei Sohma; Yousuke Chiyomori; Yoshio Hayashi; Yoshiaki Kiso; Katsumi Matsuzaki

  Peptide Science 2006, 2006

  
• “Click peptide” based on the “O-acyl isopeptide method”: development of chemical biology-oriented Alzheimer’s disease-related Aß1-42 analogues.

  Youhei Sohma; Atsuhiko Taniguchi; Maiko Kimura; Yousuke Chiyomori; Fukue Fukao; Takuma Okada; Keisuke Ikeda; Yoshio Hayashi; Tooru Kimura; Shun Hirota; Katsumi Matsuzaki; Yoshiaki Kiso

  Peptide Science 2005, 2006

  
• Thermodynamics of Hydrophobic Mismatch for Transmembrane Helix-Helix and Helix-Lipid Interactions

  YANO Yoshiaki; OGURA Mai; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2005

  
• Peptide-Membrane Interactions in Biological Sciences : Antimicrobial Peptides and Alzheimer's beta-Amyloid Peptides as Paradigms

  MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2005

  
• Thermodynamics of hydrophobic mismatch: A model peptide study

  Y Yano; M Ogura; K Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2005

  
• Membrane Insertion and Dissociation Processes of a Model Transmembrane Helix

  YANO Yoshiaki; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Feb. 2003

  
• Formation of a membrane-active form of amyloid beta-protein (A beta) via lipid raft.

  A Kakio; K Matsuzaki

  BIOPHYSICAL JOURNAL, Feb. 2003

  
• 痴呆研究と創薬の展望 アルツハイマー病中核病変とコレステロール

  柳澤 勝彦; 道川 誠; 范 企文; 澤村 直哉; 松崎 勝巳

  基礎老化研究, Apr. 2002

  
• Ganglioside-mediated formation of Alzheimer amyloid in raft-like membranes: A plausible onset mechanism of Alzheimer's disease.

  K Matsuzaki; A Kakio; K Yanagisawa

  BIOPHYSICAL JOURNAL, Jan. 2002

  
• Intervesicular transfer kinetics of a model transmembrane helix

  Y Yano; K Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2002

  
• 脂質代謝とアルツハイマー病の分子病理

  柳澤 勝彦; 道川 誠; 林 秀樹; 澤村 直哉; 松崎 勝巳

  神経化学, Sep. 2001

  
• Stability and self association of a model transmembrane helix in lipid bilayers

  Y Yano; T Takemoto; S Kobayashi; W Ohashi; M Niwa; S Futaki; Y Sugiura; K Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2001

  
• Interactions of an antimicrobial peptide, buforin 2, with lipid bilayers.

  K Matsuzaki; S Kobayashi; K Takeshima; SC Kim

  BIOPHYSICAL JOURNAL, Jan. 2000

  
• Supramolecular complex formation between magainin 2 and PGLa in lipid bilayers.

  K Matsuzaki; Y Mitani; K Tanaka; A Yamada

  BIOPHYSICAL JOURNAL, Jan. 1999

  
• Effects of polar angle on the interactions of model amphipathic helical peptides with lipid bilayers.

  K Matsuzaki; N Uematsu

  BIOPHYSICAL JOURNAL, Jan. 1999

  
• Relationship of membrane curvature to the formation of pores by magainin.

  K Matsuzaki; K Sugishita; N Ishibe; M Ueha; S Nakata; K Miyajima; RM Epand

  BIOPHYSICAL JOURNAL, Feb. 1998

  
• Transbilayer traffic of ions and lipids coupled to mastoparan X translocation

  K Matsuzaki; S Yoneyama; K Miyajima

  BIOPHYSICAL JOURNAL, Feb. 1996

  
• WHY MAGAININ PEPTIDES CAN DISCRIMINATE BETWEEN BACTERIAL AND ERYTHROCYTE-MEMBRANES

  K MATSUZAKI; K SUGISHITA; N FUJII; K MIYAJIMA

  BIOPHYSICAL JOURNAL, Feb. 1994

  

Presentations

• 神経細胞膜を介したアミロイドβタンパク質の凝集・毒性発現機構

  松崎 勝巳

  日本薬学会第144年会, 30 Mar. 2024, Invited

  
• 新規リン脂質誘導体による可溶化GPCRのリガンド結合能評価

  星遥華; 河野健一; 藤原敬宏; 黒田悠介; 山岡庸介; 高須清誠; 松崎勝巳

  日本薬学会第144年会, 30 Mar. 2024

  
• 低pH応答抗がん性ペプチドと薬物コンジュゲート体の選択的抗がん活性

  谷口 葵; 河野 健一; 松崎 勝巳

  日本薬学会第144年会, 30 Mar. 2024

  
• 曲率認識ぺプチドによるエクソソーム膜へのアルギニンペプチド修飾と細胞内導入促進

  中坊 美穂; 河野 健一; 藤原 大佑; 道上 雅孝; 松崎 勝巳; 藤井 郁雄; 中瀬 生彦

  日本薬学会第144年会, 30 Mar. 2024

  
• リン脂質誘導体カクテルによる膜タンパク質の小サイズでの安定な可溶化

  松崎 勝巳; 高木 麻衣; 秦 綾美; 長谷 綾菜; 横山 あずさ; 林田 幸一; 星 遥華; 山崎 大資; 大山 侃志; 河野 健一; 黒田 悠介; 山岡 庸介; 星野 大; 矢野 義明; 高須 清誠

  日本薬学会第144年会, 29 Mar. 2024, Invited

  
• 曲率認識ペプチドを用いた新規手法で単離した細胞外小胞の機能性評価

  河野 健一; 葛馬 佑樹; 吉尾 航一; 細川 健太; 大杉 悠斗; 藤原 敬宏; 横山 文秋; 松﨑 勝巳

  日本薬学会第144年会, 31 Mar. 2024

  
• 膜曲率認識ペプチドを利用したエクソソーム膜修飾技術の開発とDDS応用

  中坊美穂; 河野健一; 藤原大佑; 道上雅孝; 服部能英; 切畑光統; 松崎勝巳; 藤井郁雄; 中瀬生彦

  第1回 関西生物物理学研究会, 18 Mar. 2024

  
• 曲率認識ペプチドを利用したエクソソーム膜修飾とDDSへの応用

  中坊 美穂; 河野 健一; 藤原 大佑; 道上 雅孝; 松崎 勝巳; 藤井 郁雄; 中瀬 生彦

  第38回関西地区ペプチドセミナー, 09 Dec. 2023

  
• 曲率認識ペプチドを利用したエクソソーム膜修飾と細胞内導入への応用

  中坊 美穂; 河野 健一; 藤原 大佑; 道上 雅孝; 松崎 勝巳; 藤井 郁雄; 中瀬 生彦

  BioMedical Forum2024, 05 Dec. 2023

  
• 電荷反転型曲率認識ペプチドを用いた細胞外小胞の簡便な回収法の開発

  河野健一; 葛馬佑樹; 藤原敬宏; 横山文秋; 松﨑勝巳

  「日本膜学会第45年会」・「膜シンポジウム2023」合同大会, 20 Nov. 2023

  
• Curvature-sensing peptides enhancing cancer cellular uptake of extracellular vesicles

  Kenta Hosokawa; Kenichi Kawano; Katsumi Matsuzaki

  第60回ペプチド討論会, 09 Nov. 2023

  
• Extracellular-vesicle catch-and-release isolation system using a pH-dependent EV-binding curvature- sensing peptide

  Kenichi Kawano; Yuki Kuzuma; Takahiro Fujiwara; Fumiaki Yokoyama; Katsumi Matsuzaki

  第60回ペプチド討論会, 09 Nov. 2023

  
• 糖鎖に覆われた細胞外小胞膜に結合する曲率認識ペプチドの構造的柔軟性の重要さ

  河野健一; 釜阪紘平; 横山文秋; 川本純; 小川拓哉; 栗原達夫; 松崎勝巳

  第44回生体膜と薬物の相互作用シンポジウム, 20 Oct. 2023

  
• 神経細胞膜上における Aβ40 と 42 共存下での線維形成機構

  川口真由; 河野健一; 松崎勝巳

  第44回生体膜と薬物の相互作用シンポジウム, 19 Oct. 2023

  
• 低分泌型細菌株に由来する細胞外小胞検出への適用に向けた二量体化曲率認識ペプチドの開発

  河野 健一; 葛馬 佑樹; 山岡 庸介; 高須 清誠; 松﨑 勝巳

  日本薬学会第143年会, 28 Mar. 2023

  
• 細胞外小胞の単離に向けた新規pH応答性曲率認識ペプチドの設計

  葛馬 佑樹; 河野 健一; 松崎 勝巳

  日本薬学会第143年会, 28 Mar. 2023

  
• Mechanisms by which lipids shape and functionalize peptides and proteins

  Katsumi Matsuzaki

  The 59th Japanese Peptide Symposium, 28 Oct. 2022, Invited

  
• Structural factors governing vesicle detection of curvature-sensing peptides

  Kenichi Kawano; Fumiaki Yokoyama; Kouhei Kamasaka; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara; Katsumi Matsuzaki

  The 59th Japanese Peptide Symposium, 27 Oct. 2022

  
• Development of pH-responsive anticancer peptides

  Aoi Taniguchi; Kenichi Kawano; Katsumi Matsuzaki

  The 59th Japanese Peptide Symposium, 26 Oct. 2022

  
• 膜を標的とする抗菌性ペプチドの作用機構と創薬への展開

  松崎勝巳

  第43回 生体膜と薬物の相互作用シンポジウム, 06 Oct. 2022, Invited

  
• N末端置換型曲率認識ペプチドによる細胞外小胞の高感度検出

  河野健一; 葛馬佑樹; 横山文秋; 釜坂紘平; 小川拓哉; 川本純; 栗原達夫; 二木史朗; 松崎勝巳

  日本薬学会第142年会, 26 Mar. 2022

  
• 抗菌性ペプチドmagaininが細菌細胞膜とリポソーム膜の透過性を亢進するペプチド／脂質比は同じである：In-cell FRETによる研究

  鍛冶拓実; 矢野義明; 松崎勝巳

  日本薬学会第142年会, 26 Mar. 2022

  
• 生細胞膜中で形成されるアミロイドβタンパク質線維の構造解析

  角友登; 河野健一; 矢野義明; 星野大; 松崎勝巳

  第42回生体膜と薬物の相互作用シンポジウム, 28 Oct. 2021

  
• Development of antimicrobial peptide-antibiotic conjugates for improved antimicrobial activity

  Ruka Yamauchi; Kenichi Kawano; Daigo Kajiwara; Yousuke Yamaoka; Yoshiaki Yano; Kiyosei Takasu; Katsumi Matsuzaki

  第58回ペプチド討論会, 20 Oct. 2021

  
• Development of a novel pair of coiled-coils for GPCR heterooligomer detection

  Jun Takano; Yoshiaki Yano; Katsumi Matsuzaki

  日本薬学会第141年会, 27 Mar. 2021

  
• Elucidation of complex dynamic intermolecular interactions in membranes

  Katsumi Matsuzaki

  日本薬学会第141年会, 27 Mar. 2021, Invited

  
• Interplay between amino acid sequences and lipid compositions in the GXXXG-mediated self-association of transmembrane helices as revealed by single-pair FRET

  Yoshiaki Yano; Takayuki Morise; Katsumi Matsuzaki

  第57回ペプチド討論会, 10 Nov. 2020

  
• EFFECTS OF DIMERIZATION OF ANTIMICROBIAL PEPTIDES ON ANTIMICROBIAL ACTIVITY AND LPS NEUTRALIZATION

  Mayu Odaki; Yoshiaki Yano; Katsumi Matsuzak

  第57回ペプチド討論会, 10 Nov. 2020

  
• Interaction between Mint3 and FIH-1 analyzed by high-resolution NMR

  Ryo Maeda; Satoru Nagatoishi; Kouhei Tsumoto; Katsumi Matsuzaki; Masaru Hoshino

  第20回日本蛋白質科学会年会, 28 Jul. 2020

  
• Single-pair FRET measurement of transmembrane helices

  Yoshiaki Yano; Takayuki Morise; Katsumi Matsuzak

  日本薬学会第140年会, 27 Mar. 2020

  
• INTERPLAY BETWEEN AMINO ACID SEQUENCES AND LIPID COMPOSITIONS IN THE GXXXG-MEDIATED PARALLEL SELF-ASSOCIATION OF TRANSMEMBRANE HELICES AS REVEALED BY SINGLE-PAIR FRET

  Katsumi Matsuzaki

  64th of Annual Meeting of the Biophysical Society, 18 Feb. 2020

  
• How does Aβ self-aggregate on and exert toxicity against neuronal cells?

  Katsumi Matsuzaki

  International Symposium on Pathomechanisms of Amyloid Diseases, 18 Dec. 2019, Invited

  
• Development of a novel coiled–coil labeling method for heterooligomer detection

  Jun Takano; Yoshiaki Yano; Katsumi matsuzaki

  第56回ペプチド討論会, 23 Oct. 2019

  
• 神経細胞膜上で形成するアミロイド・タンパク質線維によるアポトーシス誘導機構の解明

  矢野 義明; 大久保 薫; 高田 絵里; 染田 真孝; 飯田 桂子; 平澤 明; 米原 伸; 松崎 勝巳

  第41回生体膜と薬物の相互作用シンポジウム, 19 Oct. 2019

  
• アスパラギン間 相互作用に基づく新規コイルドコイルラベル法の開発

  高野 淳; 矢野 義明; 松崎 勝巳

  第17回 フィジカルファーマフォーラム, 02 Sep. 2019

  
• Comparison between Abeta-(1–40) and Abeta-(1–42) in terms of membrane interactions and their cross interactions

  Katsumi Matsuzaki

  Joint 12th EBSA 10th ICBP-IUPAP Biophysics Congress, 21 Jul. 2019

  
• GM1 cluster as a platform of formation of toxic amyloid fibrils by Alzheimer’s Ab

  Katsumi Matsuzaki

  DFG Tagung Membrane Lipids, 10 May 2019

  
• Toxic Ab amyloids formed on neuronal membranes: their mechanism of formation and structure

  Katsumi Matsuzaki

  日本薬学会第139年会, 23 Mar. 2019, Invited

  
• 生細胞でのアミロイド前駆体蛋白質、C99中間体の会合機構の解明

  高坂 徹; 上山 和輝; 矢野 義明; 松崎 勝巳

  日本薬学会第139年会, 22 Mar. 2019

  
• Toxic amyloid tape: A novel mixed antiparallel/parallel b-sheet structure formed by Ab on GM1 clusters

  katsumi matsuzaki

  63rd Biophysical Society Annual Meeting, 03 Mar. 2019

  
• Monitoring aggregation and cytotoxicity by amyloid beta peptide on neuronal cells

  Katsumi Matsuzaki

  International Symposium on Pathomechanisms of Amyloid Diseases, 21 Dec. 2018, Invited

  
• Toxic Amyloid Fibrils Formed by Amylid beta-Peptide on Neuronal membranes: Their Mechanism of Formation and Structure

  Katsumi Matsuzaki

  10th International peptide Symposium, 07 Dec. 2018, Invited

  
• Endowment of pH Responsivity to Anti-Cancer Peptides by Introducing Unnatural Amino Acid Residues

  Naoto Tanishiki; Yoshiaki Yano; Katsumi Matsuzaki

  10th International peptide Symposium, 06 Dec. 2018

  
• Single-Pair FRET Measurement of GXXXG-Mediated Transmembrane Helix Associations-the Effects of Surrounding Residues-

  Takayuki Morise; Yoshiaki Yano; Katsumi Matsuzaki

  10th International peptide Symposium, 05 Dec. 2018

  
• Development of Peptide-Anchored Planar Lipid Bilayers

  Yusuke Higashi; Yoshiaki Yano; Katsumi Matsuzaki

  10th International peptide Symposium, 04 Dec. 2018

  
• Mechanism of Self-Association of Amyloid Precursor Protein and C99 in Living Cells

  Toru Kosaka; Yoshiaki Yano; Katsumi Matsuzaki

  10th International peptide Symposium, 04 Dec. 2018

  
• 生体膜神経細胞膜におけるアミロイドβタンパク質の毒性発現機構の 解明

  矢野 義明; 大久保 薫; 高田 絵里; 染田 真孝; 飯田 桂子; 平澤 明; 米原 伸; 松崎 勝巳

  第40回生体膜と薬物の相互作用シンポジウム, Oct. 2018

  
• 膜貫通ヘリックス会合のsingle-pair蛍光測定-GXXGモチーフにおけるグリシン残基の数及び位置の影響-

  森瀬 敬之; 矢野 義明; 松崎 勝巳

  第16回次世代を担う若手のためのフィジカル・ファーマフォーラム, Sep. 2018

  
• 非天然アミノ酸残基の導入による膜破壊ペプチドへのpH応答性の付与

  谷舗 直人; 矢野 義明; 松崎 勝巳

  日本薬学会第138年会, Mar. 2018

  
• 生体膜上で凝集したアミロイドβペプチドの毒性はオリゴマーではなく線維によって引きおこされる

  伊藤 直也; 高田 絵里; 大久保 薫; 矢野 義明; 星野 大; 佐々木 章; 金城 政孝; 松崎 勝巳

  日本薬学会第138年会, Mar. 2018

  
• Pyroglutaminated Aβ-(3–42) enhances aggregation of amyloid β-peptide on neuronal membranes at physiological concentrations: A FCS analysis

  Yoshiaki Yano; An Takeno; Katsumi Matsuzaki

  62nd Biophysical Society Annual Meeting, 19 Feb. 2018

  
• Improvement of the therapeutic index of antimicrobial peptides based on magainin 2

  東恵利華; 矢野義明; 松崎勝巳

  第54回ペプチド討論会, Nov. 2017

  
• Phenylalanine to cyclohexylalanine substitution inhibits amyloid formation by Alzheimer's amyloid beta-peptide

  源治万裕心; 矢野義明; 星野大; 松崎勝巳

  第54回ペプチド討論会, Nov. 2017

  
• Poline residue promotes self-association of transmembrane helices

  上原淳; 矢野義明; 松崎勝巳

  第54回ペプチド討論会, Nov. 2017

  
• Pyroglutaminatedアミロイドβ-(3-42)ペプチドによる生理的濃度のアミロイドβの凝集促進：細胞表面でのFCS解析

  矢野義明; 武野安; 松崎勝巳

  第39回生体膜と薬物の相互作用シンポジウム, Oct. 2017

  
• Formation of toxic fibrils by amyloid β-protein mediated by GM1 ganglioside on neuronal membranes

  Katsumi Matsuzaki

  International Symposium on Protein Misfolding Diseases, 02 Aug. 2017, Invited

  
• Mechanisms of abnormal aggregation and toxicity of amyloid β-protein on neuronal membranes

  Katsumi Matsuzaki

  19th IUPAC Congress/11th EBSA Congress, 20 Jul. 2017, Invited

  
• Mechanisms of abnormal aggregation and toxicity of Alzheimer's amyloid β-protein on neuronal membranes

  Katsumi Matsuzaki

  Gordon Research Conference Membrane Protein Folding, 07 Jun. 2017, Invited

  
• Mechanisms of abnormal aggregation and toxicity of Alzheimer’s amyloid β-protein on neuronal membranes

  katsumi matsuzaki

  日本薬学会第137年会, Mar. 2017

  
• Molecular basis on mechanisms of action and cell selectivity of membrane-acting peptides

  katsumi matsuzaki

  日本薬学会第137年会, Mar. 2017

  
• magainin 2をベースとした抗菌性ペプチドの治療係数向上の試み

  東 恵利華; 矢野 義明; 松崎 勝巳

  日本薬学会第137年会, Mar. 2017

  
• 膜貫通3-helix bundle形成の1分子FRET測定

  矢野 義明; 渡邊 由宇太; 松崎 勝巳

  日本薬学会第137年会, Mar. 2017

  
• 生細胞におけるアミロイド前駆体タンパク質の会合状態・会合制御因子の解明

  矢野義明; 上山和輝; 松崎勝巳

  第38回生体膜と薬物の相互作用シンポジウム, Nov. 2016

  
• GXXXGモチーフによる膜貫通ヘリックスの二量体形成：会合トポロジー制御下での一分子FRET研究

  矢野義明; 渡邊由宇太; 松崎勝巳

  第54回日本生物物理学会年会, Nov. 2016

  
• Single-molecule observation of transient association of transmembrane helices: roles of GXXXG motif, number of membrane spanning, and cholesterol

  松崎勝巳

  第53回ペプチド討論会, Oct. 2016

  
• Stoichiometric analysis of oligomeric states of three class-A GPCRs, chemokine-CXCR4, dopamine-D2, and prostaglandin-EP1 receptors, on living cells

  河野健一; 八木徹哉; 矢野義明; 松崎勝巳

  第53回ペプチド討論会, Oct. 2016

  
• PEPTIDE–BASED LIPOSOME–CELL FUSION SYSTEM FOR CELLULAR DELIVERY OF LIPOSOMAL COMPONENTS

  Nozomu Fukada; Yoshiaki Yano; Katsumi Matsuzaki

  34th European Peptide Symposium/8th International Peptide Symposium, 06 Sep. 2016

  
• 一分子蛍光測定法を用いた二回膜貫通ヘリックス会合駆動力の測定

  渡邊由宇太; 近藤小太郎; 矢野義明; 松崎勝巳

  第 14 回次世代を担う若手のためのフィジカル・ファーマフォーラム, Aug. 2016

  
• How do membranes initiate Alzheimer's Disease? Formation of toxic amyloid fibrils by the amyloid beta-protein

  Katsumi Matsuzaki

  CECAM Workshop Multiscale modeling of biomolecular aggregation and protein-membrane interactions in amyloid diseases, 12 Jul. 2016, Invited

  
• 膜タンパク質研究の新ツール：coiled-coil標識法

  松崎勝巳

  油化学関連シンポジウムin姫路, Jun. 2016

  
• アミロイド前駆体タンパク質の会合制御ドメインの解明

  上山和輝; 矢野義明; 松崎勝巳

  日本薬学会第136年会, Mar. 2016

  
• 二回膜貫通ヘリックス間相互作用の一分子蛍光測定に用いるモデルペプチドの合成

  渡邊由宇太; 近藤小太郎; 矢野義明; 松崎勝巳

  日本薬学会第136年会, Mar. 2016

  
• Relationship between aggregation of amyloid-β protein on cells and cytotoxicity

  Naoya Itoh; Eri Takada; Yoshiaki Yano; Masaru Hoshino; Katsumi Matsuzaki

  60th Biophysical Society Annual Meeting, 29 Feb. 2016

  
• 細胞膜上におけるアミロイドβタンパク質の凝集状態と細胞毒性との関係

  高田絵里; 伊藤直也; 矢野義明; 星野大; 飯田桂子; 平澤明; 松崎勝巳

  第37回生体膜と薬物の相互作用シンポジウム, Nov. 2015

  
• TOXIC AMYLOID TAPE: NOVEL MIXED ANTIPARALLEL/PARALLEL β-SHEET STRUCTURE FORMED BY Aβ ON GM1 CLUSTERS

  Yuki Okada; Keisuke Ikeda; Yoshiaki Yano; Masaru Hoshino; Yoshio Hayashi; Yoshiaki Kiso; Hikari Itoh-Watanabe; Akira Naito; Katsumi Matsuzaki

  第52回ペプチド討論会, Nov. 2015

  
• 毒性型アミロイドテープ： GM1 クラスター上で形成される新規Aβ 逆平行／平行混合β シート構造

  岡田祐貴; 池田恵介; 矢野義明; 星野大; 林良雄; 木曽良明; 伊藤ー渡邊ひかり; 内藤晶; 松崎勝巳

  第53回日本生物物理学会年会, Sep. 2015

  
• Identification of toxic Aβ aggregates and cross seeding between Aβ40 and Aβ42 on neuronal cells

  Naoya Itoh; Eri Takada; Yoshiaki Yano; Masaru Hoshino; Katsumi Matsuzaki

  The 10th EBSA European Biophysics Congress, 22 Jul. 2015

  
• Novel structure of toxic amyloid fibrils formed by Aβ on GM1 clusters

  Yuki Okada; Hiroshi Ueno; Yoshiaki Yano; Masaru Hoshino; Hikari Itoh-Watanabe; Akira Naito; Katsumi Matsuzaki

  The 24th American Peptide Symposium, 21 Jun. 2015

  
• Sp1とTAF4の天然変性領域を介した相互作用の解析

  松崎 勝巳

  第13回日本蛋白質科学会年会, Jun. 2015

  
• 生細胞におけるアミロイド前駆体タンパク質の会合状態解析

  上山和輝; 矢野義明; 松崎勝巳

  日本薬学会第135年会, Mar. 2015

  
• 共有結合型コイルドコイルラベル法の確立とグリコフォリンAの会合状態解析

  古川奈美; 矢野義明; 小野智史; 松崎勝巳

  日本薬学会第135年会, Mar. 2015

  
• The presence of antiparallel beta-sheets in toxic fibrils formed by abeta on GM1 clusters

  Yuki Okada; Hiroshi Ueno; Yoshiaki Yano; Masaru Hoshino; Hilari-Itoh-Watanabe; Akira Naito; Katsumi Matsuzaki

  Biophysical society 59th annual meeting, 11 Feb. 2015

  
• Single-molecule FRET detection of GXXXG-mediated transmembrnae helical interactions

  Yoshiaki Yano; Kotaro Kondo; Katsumi Matsuzaki

  Biophysical society 59th annual meeting, 11 Feb. 2015

  
• マイクロアレイを用いたアミロイドbeta蛋白質による細胞死メカニズムの考察

  高田絵里; 岡田祐貴; 矢野義明; 星野大; 飯田桂子; 平澤明; 松崎勝巳

  第36回生体膜と薬物の相互作用シンポジウム, Nov. 2014

  
• ガングリオシドクラスターを介して形成される毒性型アミロイドbeta蛋白質線維の構造解析

  岡田祐貴; 矢野義明; 星野大; 松崎勝巳

  第36回生体膜と薬物の相互作用シンポジウム, Nov. 2014

  
• 新規小分子ラベル法とin-cell FRETを用いた膜タンパク質の会合状態の定量的解析

  河野健一; 矢野義明; 大前薫; 松崎紗矢香; 松崎勝巳

  第64回日本薬学会近畿支部大会, Oct. 2014

  
• Aggregation of amyloid beta-peptides on GM1 ganglioside-express cell membranes

  Naoya Ito; Yoshiaki Yano; Katsumi Matsuzaki

  第51回ペプチド討論会, Oct. 2014

  
• Contributions of GXXXG motif to transmembrane helix-helix interactions as revealed by single molecule FRET

  近藤小太郎; 矢野義明; 松崎勝巳

  第52回日本生物物理学会, Sep. 2014

  
• Effect of C-terminal truncation of chaperonine GroEL on the yield of an in-cage folding of GFP

  So Ishino; Yasushi Kawata; Hideki Taguchi; Katsumi Matsuzaki; Masaru Hoshino

  第52回日本生物物理学会, Sep. 2014

  
• The interaction between transcription factors Sp1 and TAF4 via the intrinsically disordered regions

  Emi Hibino; Rintaro Inoue; Masaaki Sugiyama; Jun Kuwahara; Katsumi Matsuzaki

  第52回日本生物物理学会, Sep. 2014

  
• 一分子蛍光測定法を用いた、膜貫通ヘリックス間相互作用へのGXXXGモチーフの寄与の解析

  近藤小太郎; 矢野義明; 松崎勝巳

  第12回次世代を担う若手のためのフィジカル・ファーマフォーラム, Jul. 2014

  
• Dimer is a minimal functional unit of influena A virus M2 channel on Living cells

  Kenichi Kawano; Yoshiaki Yano; Katsumi Matsuzaki

  Biophysical society 58th annual meeting, 16 Feb. 2014

  
• The amantadine-resistant S31N mutant of influenza A virus M2 proteins stably forms a dimer on living cells

  Kenichi Kawano; Yoshiaki Yano; Katsumi Matsuzaki

  Biophysical society 58th annual meeting, 16 Feb. 2014

  
• コイルドコイルラベル法を用いた生細胞での上皮成長因子受容体多量体形成の検出

  山下博隆; 河野健一; 矢野義明; 松崎勝巳

  第35回生体膜と薬物の相互作用シンポジウム, Nov. 2013

  
• Dimer is a minimal functional unit for influenza A virus M2 channel on biomembrane

  Kenichi Kawano; Yoshiaki Yano; Katsumi Matsuzaki

  第50回ペプチド討論会, Nov. 2013

  
• コイルドコイル蛍光ラベル法を用いた生細胞での上皮成長因子受容体多量体形成の検出

  山下博隆; 河野健一; 矢野義明; 松崎勝巳

  第11回次世代を担う若手のためのフィジカル・ファーマフォーラム, Aug. 2013

  
• Revisiting the stability of an SR398/GroES chaperonin complex

  石野聡; 松崎勝巳; 星野大

  第13回日本蛋白質科学会年会, Jun. 2013

  
• 転写因子Sp1とTAF4の天然変性領域を介した相互作用の解析

  日比野絵美; 桑原淳; 松崎勝巳; 星野大

  第13回日本蛋白質科学会年会, Jun. 2013

  
• GM1 cluster mediated-aggregation of alzheimer’s amyloid β-protein

  Katsumi Matsuzaki

  Biophysical Society Membrane Protein Folding Meeting, 21 May 2013

  
• 膜タンパク質変成作用の少ない可溶化剤の開発

  林田幸一; 茂木雄三; 山岡庸介; 高須清誠; 矢野義明; 松崎勝巳

  日本薬学会第133年会, Mar. 2013

  
• Oligomeric states of full length influenza A virus M2 proteins on biological membranes

  Kenichi Kawano; Sayaka Matsuzaki; Kaoru Omae; Yoshiaki Yano; Katsumi Matsuzaki

  Biophysical society 57th annual meeting, 03 Feb. 2013

  
• Detection of Oligomerization of Membrane Proteins using Coiled-Coil Tag-Probe Labeling Method and In-Cell Fluorescence Spectroscopy

  Kenichi Kawano; Kaoru Omae; Sayaka Matsuzaki; Yoshiaki Yano; Katsumi Matsuzaki

  Biophysical society 57th annual meeting, 03 Feb. 2013

  
• Single-Pair FRET Measurement of GXXXG-Mediated Transmembrane Helix Associations-the Effects of Surrounding Residues-

  Takayuki Morise; Yoshiaki Yano; Katsumi Matsuzaki

  10th International peptide Symposium, 05 Dec. 2012

  
• インフルエンザAウイルスM2プロトンチャネルの生体膜中における会合状態

  河野健一; 松崎紗矢香; 大前薫; 矢野義明; 松崎勝巳

  第34回生体膜と薬物の相互作用シンポジウム, Nov. 2012

  
• 膜貫通ヘリッククス会合―解離過程のリアルタイム1分子蛍光観測

  矢野義明; 木谷亮太; 松崎勝巳

  第34回生体膜と薬物の相互作用シンポジウム, Nov. 2012

  
• Mechanism of antiviral amantadine resistance of influenza A virus M2 proton channel

  Kenichi Kawano; Sayaka Matsuzaki; Kaoru Omae; Yoshiaki Yano; Katsumi Matsuzaki

  第49回ペプチド討論会, Nov. 2012

  
• Analysis of oligomeric state of beta2 adrenergic receptors on living cell surface

  Yoshiaki Yano; Kenichi Kawano; Kaoru Omae; Sayak Matsuzaki; Katsumi Matsuzaki

  第49回ペプチド討論会, Nov. 2012

  
• Comparoson of aggregation of rat and human amyloid beta-peptides mediated by GM1 ganglioside clusters

  Hiroshi Ueno; Takahiro Yamaguchi; Saori Fukunaga; Masaru Hoshino; Katsumi Matsuzaki

  第49回ペプチド討論会, Nov. 2012

  
• インフルエンザAウィルスM2プロトンチャネルの抗ウィルス薬アマンタジン耐性メカニズム

  河野健一; 松崎紗矢香; 大前薫; 矢野義明; 松崎勝巳

  第10回次世代を担う若手のためのフィジカル・ファーマフォーラム, Aug. 2012

  
• Stoichiometric analysis of oligomerization of membrane proteins on living cell surface

  Kenichi Kawano; Kaoru Omae; Sayaka Matsuzaki; Yoshiaki Yano; Katsumi Matsuzaki

  The 7th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceuticl Sciences for Young Scientists, 23 May 2012

  
• M2プロトンチャネルのpH依存的会合状態の変化

  河野健一; 大前薫; 松崎紗矢香; 矢野義明; 松崎勝巳

  日本薬学会第132年会, Mar. 2012

  
• Association-dissociation dynamics of transmembrane helices as detected by single-molecule fluorescence microscopy

  Yoshiaki Yano; Ryota Kitani; Katsumi Matsuzaki

  Biophysical society 56th annual meeting, 26 Feb. 2012

  
• Family A GPCRの受容体活性化に会合体形成は本当に必要か

  河野健一; 大前薫; 松崎紗矢香; 矢野義明; 松崎勝巳

  第33回生体膜と薬物の相互作用シンポジウム, Nov. 2011

  
• Yoshiaki Yano, Arisa Yamamoto, mai Ogura, Katsumi Matsuzaki

  Yoshiaki Yano; Arisa Yamamoto; mai Ogura; Katsumi Matsuzaki

  第49回日本生物物理学会, Sep. 2011

  
• Family A GPCRの受容体活性に会合体形成は本当に必要か

  河野健一; 大前薫; 矢野義明; 松崎勝巳

  第9回次世代を担う若手のためのフィジカル・ファーマフォーラム, Sep. 2011

  
• 転写因子Sp1の転写活性化ドメイン間相互作用の解明

  平松直子; 日比野絵美; 松崎勝巳; 桑原淳; 星野大

  第9回次世代を担う若手のためのフィジカル・ファーマフォーラム, Sep. 2011

  
• 疎脂性相互作用：脂質により誘起される膜貫通ヘリックス間相互作用

  矢野義明; 山本亜梨沙; 小倉まい; 木谷亮太; 松崎勝巳

  第9回次世代を担う若手のためのフィジカル・ファーマフォーラム, Sep. 2011

  
• Improvement of probe peptides for coiled-coil labeling introducing phosphopeptides

  Satoshi Ono; Yoshiaki Yano; katsumi Matsuzaki

  第48回ペプチド討論会, Sep. 2011

  
• Low-polarity environment is important for the formation of toxic amyloid beta aggreagates

  Saori Fukunaga; Takahiro yamaguchi; Yoshiaki Yano; Masaru Hoshino; Katsumi Matsuzaki

  第48回ペプチド討論会, Sep. 2011

  
• Lipophobic interaction: lipid-induced association of transmembrane helices

  Yoshiaki Yano; Arisa Yamamoto; Mai Ogura; Katsumi Matsuzaki

  第48回ペプチド討論会, Sep. 2011

  
• コイルドコイル蛍光ラベル法を用いた生細胞膜受容体の内在化・会合のイメージング解析

  矢野義明; 竹田有希; 河野健一; 大前薫; 松崎勝巳

  日本ケミカルバイオロジー学会第6回年会, May 2011

  
• 新規小分子蛍光ラベル法を用いたbeta2アドレナリン受容体の生体膜における会合状態の解析

  河野健一; 矢野義明; 松崎勝巳

  日本ケミカルバイオロジー学会第6回年会, May 2011

  
• 新規蛍光ラベル法による受容体内在化を指標としたリガンドスクリーニング法の開発

  竹田有希; 矢野義明; 松崎勝巳

  日本薬学会第131年会, Mar. 2011

  
• 抗菌性ペプチドmagainin2のGM1ガングリオシドとの相互作用

  宮崎優; 矢野義明; 松崎勝巳

  日本薬学会第131年会, Mar. 2011

  

Books and Other Publications

• アミロイドβペプチドとアルツハイマー病：神経細胞膜の役割

  松崎勝巳

  CSJ Current Review 39 生体分子と疾患 ヘルスサイエンスの切り札としての化学（日本化学会編）、156–161、化学同人, 25 Aug. 2021

  
• Antimicrobial peptides : basics for clinical application

  松崎 勝巳

  Springer, 2019, Not refereed

  Find Kyoto University's collection of books :

  
• Coiled-coil tag-probe labeling methods for live-cell imaging of membrane receptors

  Yoshiaki Yano; Kenichi Kawano; Kaoru Omae; Katsumi Matsuzaki\t

  Methods in Enzymology, 504, 355-370, 2012, Not refereed

  
• 新規蛍光標識法を用いた創薬ターゲット膜受容体のイメージング解析

  松崎勝巳; 矢野義明

  ナノバイオ技術と最新創薬応用研究 、35-39、メディカルドゥ, 2012, Not refereed

  
• 特異的蛍光ラベル法による生細胞での受容体イメージング

  松﨑 勝巳

  薬学分析科学の最前線,170-171, 2009, Not refereed

  
• 生体防御の仕組みを利用して抗菌剤を創る：平成版がまの油の話

  松﨑 勝巳

  新しい薬をどう創るか 創薬研究の最前線,第8章, 2007, Not refereed

  
• 脂質膜ポリペプチド相互作用

  松﨑 勝巳

  生物物理学ハンドブック,第3章8節, 2007, Not refereed

  
• （SBO 19）生体膜の立体構造を規定する相互作用について、説明できる。

  松﨑 勝巳

  物理系薬学（Ⅲ．生体分子・化学物質の構造決定）,106-209, 2006, Not refereed

  
• ガングリオシドクラスターを介したアルツハイマーβ‐アミロイドタンパク質の凝集

  松﨑 勝巳

  未来を拓く糖質科学,244-246, 2005, Not refereed

  
• ペプチドとリポソームの相互作用

  松﨑 勝巳

  リポソーム応用の新展開 〜人工細胞の開発に向けて〜,167-175, 2005, Not refereed

  
• 抗菌性ペプチドとinnate immunity

  松﨑 勝巳

  Annual Review 免疫 2005,１,177-182, 2004, Not refereed

  
• LIPID RAFT AS A NIDUS FOR THE CONFORMATIONAL ALTERNATION AND THE AGGREGATION OF ALZHEIMER'S AMYLOID β-PROTEIN

  松﨑 勝巳

  Nova Biomedical,6,151-166, 2003, Not refereed

  
• Development of Novel Antimicrobial Agents : Emerging Strategies

  松﨑 勝巳

  Horizon Scientific Press,, 2001, Not refereed

  
• 生命薬学テキストシリーズ「物理化学」

  松﨑 勝巳

  共立出版,, 1999, Not refereed

  
• Biomembrane Structures

  松﨑 勝巳

  IOS Press,/,205, 1998, Not refereed

  
• 薬学の機器分析

  松﨑 勝巳

  広川書店,/,195, 1991, Not refereed

  

Industrial Property Rights

• 特許5182671, コイルドコイルを利用した膜タンパク質標識方法

  

Awards

• 1991

  日本薬学会近畿支部, 日本薬学会近畿支部奨励賞
• 1996

  日本ペプチド学会, 日本ペプチド学会奨励賞
• 1997

  日本薬学会, 日本薬学会奨励賞
• 25 Nov. 2011

  Boehringer Ingelheim, ベルツ賞１等賞
• 26 Mar. 2021

  The Pharmaceutical Society of Japan, The Pharmaceutical Society of Japan Award
• 27 Oct. 2022

  The Japanese Peptide Society, JPS Award

  Mechanisms by which lipids shape and functionalize peptides and proteins, Japan, Japan society

External funds: Kakenhi

• In-cell分光法によるアミロイドβ産生制御機構・構造変化の解明と創薬

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related

  Kyoto University

  松崎 勝巳

  From 01 Apr. 2021, To 31 Mar. 2025, Granted

  アルツハイマー病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02615/
• High resolution NMR structure determination of membrane proteins using novel phospholipid analogs

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 47:Pharmaceutical sciences and related fields

  Kyoto University

  Katsumi Matsuzaki

  From 28 Jun. 2019, To 31 Mar. 2021, Project Closed

  膜タンパク質;高分解能NMR;可溶化剤

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22493/
• Development of a small-sized labeling method for membrane proteins and its application for heterooligomer analysis

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related

  Kyoto University

  Katsumi Matsuzaki

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  膜タンパク質;蛍光イメージング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02561/
• Novel Phospholipid Analogs for NMR Structural Determination of Membrane Proteins

  Grant-in-Aid for Challenging Research (Exploratory)

  Kyoto University

  Katsumi Matsuzaki

  From 30 Jun. 2017, To 31 Mar. 2019, Project Closed

  膜タンパク質;高分解能NMR;可溶化剤;ＮＭＲ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19485/
• Development of a novel fluorescent labeling method for detecting heterooligomers of membrane proteins on living cells

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Matsuzaki Katsumi

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  蛍光イメージング;膜タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04636/
• Development of phospholipid analogs for stable solubilization of membrane proteins and application for high resolution NMR analysis

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Katsumi Matsuzaki

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  膜タンパク質;可溶化剤;脂質ナノディスク;無細胞合成

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670012/
• Association dynamics of transemrbane helices detected by single-molecle FRET

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Yoshiaki Yano

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  膜タンパク質フォールディング;モデル膜貫通へリックス;一分子FRET;膜貫通ヘリックス;一分子計測;モデル膜貫通ヘリックス;一分子蛍光エネルギー移動

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460034/
• Development of novel nano discs for structural analysis of membrane proteins

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Katsumi MATSUZAKI

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  膜蛋白質;可溶化剤;膜タンパク質;蛋白質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659016/
• Application of novel labeling method for membrane proteins to aggregational analysis and its sophistication

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Katsumi MATSUZAKI

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  膜タンパク質;オリゴマー化;蛍光イメージング;クロスリンク;イメージング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24390009/
• Visualization and analysis of receptor oligomerization in living cells by using novel fluorescence labeling method

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Katsumi MATSUZAKI

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  蛍光イメージング;GPCR;オリゴマー化;βアドレナリン受容体;蛍光励起エネルギー移動;コンフォメーション変化;β2アドレナリン受容体;グルタミン酸受容体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390007/
• 抗菌性ペプチドをベースとした世界初のエンドトキシンショック治療薬の開発

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  松崎 勝巳

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  エンドトキシンショック;抗菌性ペプチド;リポ多糖;ポリエチレングリコール;タキプレシンI;細胞毒性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20659005/
• 膜透過型細胞内ループを用いたGPCRのGタンパク質活性化機構解明

  Grant-in-Aid for Exploratory Research

  Kyoto University

  松崎 勝巳

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  GPCR;細胞内ループ;膜透過性;アルキル化;抗菌性ペプチド;膜透過ペプチド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17651125/
• GM1結合型アミロイドβ蛋白の構造解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  松崎 勝巳

  From 01 Apr. 2005, To 31 Mar. 2006, Project Closed

  アルツハイマー病;アミロイドβ蛋白;脂質ラフト;ガングリオシド;凝集阻害;線維構造

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17025022/
• アミロイドβ蛋白の凝集開始初期過程の高感度解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  松崎 勝巳

  From 01 Apr. 2004, To 31 Mar. 2005, Project Closed

  アルツハイマー病;アミロイドβ蛋白;脂質ラフト;ガングリオシド;コレステロール;細胞毒性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16015258/
• 脂質ラフトにおける膜活性型アミロイドβ蛋白の形成と防御

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  松崎 勝巳

  From 01 Apr. 2003, To 31 Mar. 2004, Project Closed

  アルツハイマー病;アミロイドβ蛋白;脂質ラフト;ガングリオシド;β-シート;凝集体;細胞毒性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15016058/
• ELUCIDATION OF THE MECHANISM OF EFFECTIVE MEMBRANE PERMEATION OF BUFORIN 2 AND ITS APPLICATION TO VECTOR FOR INTRACELLULAR DRUG DELIVERY

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Katsumi MATSUZAKI

  From 01 Apr. 2002, To 31 Mar. 2005, Project Closed

  抗菌性ペプチド;ブフォリン2;膜透過;静電反発;ペプチド-脂質超分子複合体ポア;マガイニン2;両親媒性ヘリックス;細胞透過ペプチド;プロリン;シス-トランス互変異性;濃度依存性;曲率;細胞膜透過;薬物キャリアー;ベクター;細胞内移行;ドラックデリバリー;細胞毒性, ANTIMICROBIAL PEPTIDE;BUFORIN 2;TRANSLOCATION;ELECTROSTATIC REPULSION;PEPTIDE-LIPID SUPRAMOLECULAR COMPLEX PORE;MAGAININ 2;AMPHIPATHIC HELIX;CELL PENETRATING PEPTIDE

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14572091/
• ラフト様脂質環境におけるアミロイドβ蛋白の凝集機構の解明と凝集体の特性解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  松崎 勝巳

  From 01 Apr. 2002, To 31 Mar. 2003, Project Closed

  アルツハイマー病;アミロイドβ蛋白;アミロイド線維;脂質ラフト;ガングリオシド;β-シート;シャペロン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14017048/
• 膜環境下で形成される異種生体防御ペプチド間の希少高活性超分子

  Grant-in-Aid for Scientific Research on Priority Areas

  Science and Engineering

  Kyoto University

  松崎 勝巳

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  抗菌性ペプチド;マガイニン;PGLa;相乗効果;溶血性;超分子;生体防御ペプチド;マガイニン2;分子認識;α-ヘリックス;脂質膜

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13024244/
• An investigation into molecular mechanism underlying Aβ assembly

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  National Institute for Longevity Sciences

  Katsuhiko YANAGISAWA

  From 01 Apr. 2000, To 31 Mar. 2005, Project Closed

  アルツハイマー病;アミロイド蛋白;ガングリオシド;アポリポ蛋白E;シナプス;マイクロドメイン;遺伝子変異型;遺伝的変異型;アミロイドβ蛋白;老人斑;GM1ガングリオシド;コレステロール, Alzheimer's disease;amyloid β-protein;ganglioside;apolipoprotein F.;synapse;microdomain;hereditary variant

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12210022/
• 細胞質分裂に関与するスフィンゴ脂質シグナリング

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  小堤 保則

  From 01 Apr. 2000, To 31 Mar. 2005, Project Closed

  サイコシン;多核;細胞内小器官;細胞質分裂;スフィンゴ脂質;MSS4;PI4,5P2;Rom2;リソソーム;初期エンドソーム;アセチル化;Krabbe病;Globoid cell;glactosylsphimgosine;多核細胞;酵母;ISP-1;krabbe病;Globoid cells;galactosylsphingosine;COS細胞;プロテインキナーゼ;リン酸化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12140202/
• 脂質膜中での生体防御ペプチド間のヘテロ分子認識に基づく高活性超分子形成

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Kyoto University

  松崎 勝巳;松ざき 勝巳

  From 01 Apr. 1997, To 31 Mar. 1999, Project Closed

  抗菌性ペプチド;マガイニン2;PGLa;相乗効果;超分子;膜透過性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09771946/
• 生体防御ペプチドをリ-ドとした選択毒性の高い抗菌性ペプチドの創製

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Kyoto University

  松崎 勝巳

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  抗菌剤;グラム陰性菌;マガイニン;ペプチド;静電的相互作用;膜

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08772061/
• ペプチド-脂質超分子複合体ポアによるペプチド・イオン・脂質の共役膜輸送

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  松崎 勝己

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  ペプチド;脂質;超分子複合体;マガイニン;マストパラン;フリッププロップ;膜透過

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08219223/
• Interactions of antibiotic peptides with lipid membranes

  Grant-in-Aid for General Scientific Research (B)

  Kyoto University

  Koichiro MIYAJIMA

  From 01 Apr. 1990, To 31 Mar. 1992, Project Closed

  ヒペルシン;トリコポリン;マガイニン;タキプレシン;脂質膜;膜透過性;コンホメ-ション;配向;タチプレシン, Hypelcin;Trichopolyn;Magainin;Tachyplesin;Lipid membrane;Membrane permeability;Conformation;Orientation

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02453144/
• 新規リン脂質誘導体可溶化剤を用いた革新的膜タンパク質研究プラットホームの構築

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 47:Pharmaceutical sciences and related fields

  Kyoto University

  松崎 勝巳

  From 30 Jun. 2023, To 31 Mar. 2025, Granted

  膜タンパク質可溶化;膜タンパク質;可溶化剤

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K18184/
• In-cell分光法によるアミロイドβ産生制御機構・構造変化の解明と創薬

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related

  Kyoto University

  松崎 勝巳

  From 01 Apr. 2021, To 31 Mar. 2025, Granted

  アルツハイマー病;アミロイドβ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K21355/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Sciences and Ethics

  U129, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  4202, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Physical Chemistry for Drug Discovery B

  8202, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Physical Chemistry for Drug Discovery A

  8201, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Training(Pharmaceutical and Biomedical Analysis)

  D133, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar in Basic Biophysical Chemistry

  2302, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Physical Chemistry for Drug Discovery

  1217, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Physical Chemistry for Drug Discovery

  8101, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Pharmaceutical Sciences II

  6006, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Laboratory Techniques in Physical Chemistry

  1206, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Basic Physical Chemistry II

  1212, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Basic Physical Chemistry I

  1211, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Laboratory Techniques in Physical Chemistry

  1206, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Physical Chemistry 2 (Electro- and Interface- Chemistry)

  A102, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Physical Chemistry 4 (Biophysical Chemistry)

  A104, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Physical Chemistry IV (Biophysical Chemistry)

  C104, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Physical Chemistry II (Electro- and Nano- Chemistry)

  C102, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Basic Biophysical Chemistry

  3202, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Sciences and Ethics

  U129, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Physical Chemistry for Drug Discovery B

  8202, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  4202, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Pharmaceutical and Biomedical Analysis)

  D133, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Pharmaceutical and Biomedical Analysis)

  B804, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Pharmaceutical and Biomedical Analysis)

  E804, Year-long, Faculty of Pharmaceutical Sciences, 14
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Basic Biophysical Chemistry

  3202, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Pharmaceutical and Biomedical Analysis)

  8133, Year-long, Faculty of Pharmaceutical Sciences, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Physical Chemistry II (Electro- and Nano- Chemistry)

  C102, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physical Chemistry 4 (Biophysical Chemistry)

  A104, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physical Chemistry 2 (Electro- and Interface- Chemistry)

  A102, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physical Chemistry IV (Biophysical Chemistry)

  C104, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Physical Chemistry

  1206, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Physical Chemistry

  1206, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar in Basic Biophysical Chemistry

  2302, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Physical Chemistry for Drug Discovery

  1217, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Basic Physical Chemistry II

  1212, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Physical Chemistry for Drug Discovery

  8101, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Pharmaceutical Sciences II

  6006, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  4202, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar in Basic Biophysical Chemistry

  2302, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Physical Chemistry IV (Biophysical Chemistry)

  C104, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Pharmaceutical Sciences and Ethics

  U129, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Basic Biophysical Chemistry

  3202, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Pharmaceutical and Biomedical Analysis)

  8133, Year-long, Faculty of Pharmaceutical Sciences, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Laboratory Techniques in Physical Chemistry

  1206, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Pharmaceutical and Biomedical Analysis)

  B804, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Basic Physical Chemistry I

  1211, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Physical Chemistry 4 (Biophysical Chemistry)

  A104, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Physical Chemistry for Drug Discovery

  8101, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Physical Chemistry for Drug Discovery

  1217, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Physical Chemistry II (Electro- and Nano- Chemistry)

  C102, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Physical Chemistry for Drug Discovery A

  8201, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Pharmaceutical and Biomedical Analysis)

  D133, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Physical Chemistry 2 (Electro- and Interface- Chemistry)

  A102, Spring, Faculty of Pharmaceutical Sciences, 2
• From Apr. 2011, To Mar. 2012

  分析学Ｉ（薬品生物分析学）

  Spring, 薬学部
• From Apr. 2011, To Mar. 2012

  生物物理化学

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  特別実習（薬品機能解析学）

  Year-long, 薬学部
• From Apr. 2011, To Mar. 2012

  物理化学４（生物物理化学）

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  分析化学１（薬品分析化学）

  Spring, 薬学部
• From Apr. 2011, To Mar. 2012

  創薬物理化学エクササイズ１

  Spring, 薬学部
• From Apr. 2011, To Mar. 2012

  特別実習[薬品機能解析学]

  Year-long, 薬学部
• From Apr. 2011, To Mar. 2012

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Introduction to Basic Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Advanced Basic Physical Chemistry II

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Laboratory Practice in Basic Analytical Chemistry and

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  An Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Medicinal Physical Chemistry Exercise 2

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Physical Sciences for Drug Discovery

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  doctoral program

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  doctoral program

  Fall, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Introduction to Basic Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Advanced Basic Physical Chemistry I

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Physical Chemistry II (Electro-and Interface-Chemistry)

  Spring, 薬学部
• From Apr. 2012, To Mar. 2013

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Physical Chemistry 2 (Electro- and Interface- Chemistry)

  Spring, 薬学部
• From Apr. 2012, To Mar. 2013

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2012, To Mar. 2013

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2012, To Mar. 2013

  Biophysical Chemistry

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  An Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2013, To Mar. 2014

  Physical Chemistry 2 (Electro- and Interface- Chemistry)

  Spring, 薬学部
• From Apr. 2013, To Mar. 2014

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2013, To Mar. 2014

  Medicinal Physical Chemistry Exercise 2

  Fall, 薬学部
• From Apr. 2013, To Mar. 2014

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2013, To Mar. 2014

  Introduction to Basic Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Advanced Basic Physical Chemistry II

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  doctoral program

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  doctoral program

  Fall, 薬学研究科
• From Apr. 2013, To Mar. 2014

  An Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Physical Sciences for Drug Discovery

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2014, To Mar. 2015

  Physical Chemistry 2 (Electro- and Interface- Chemistry)

  Spring, 薬学部
• From Apr. 2014, To Mar. 2015

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2014, To Mar. 2015

  Medicinal Physical Chemistry Exercise 2

  Fall, 薬学部
• From Apr. 2014, To Mar. 2015

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2014, To Mar. 2015

  Introduction to Basic Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Basic Physical Chemistry I

  Spring, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  An Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Physical Sciences for Drug Discovery

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Medicinal Physical Chemistry Exercise 2

  Fall, 薬学部
• From Apr. 2015, To Mar. 2016

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Introduction to Basic Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Basic Physical Chemistry II

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2015, To Mar. 2016

  Physical Chemistry 2 (Electro- and Interface- Chemistry)

  Spring, 薬学部
• From Apr. 2015, To Mar. 2016

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2015, To Mar. 2016

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2015, To Mar. 2016

  An Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Medicinal Physical Chemistry Exercise 2

  Fall, 薬学部
• From Apr. 2016, To Mar. 2017

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Introduction to Basic Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Basic Physical Chemistry I

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2016, To Mar. 2017

  Physical Chemistry 2 (Electro- and Interface- Chemistry)

  Spring, 薬学部
• From Apr. 2016, To Mar. 2017

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2016, To Mar. 2017

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2016, To Mar. 2017

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Medicinal Physical Chemistry Exercise 2

  Fall, 薬学部
• From Apr. 2017, To Mar. 2018

  Introduction to Physical Chemistry for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Basic Physical Chemistry II

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2017, To Mar. 2018

  Physical Chemistry 2 (Electro- and Interface- Chemistry)

  Spring, 薬学部
• From Apr. 2017, To Mar. 2018

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2017, To Mar. 2018

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2017, To Mar. 2018

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Medicinal Physical Chemistry Exercise 2

  Fall, 薬学部
• From Apr. 2018, To Mar. 2019

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Basic Physical Chemistry I

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2018, To Mar. 2019

  Physical Chemistry 2 (Electro- and Interface- Chemistry)

  Spring, 薬学部
• From Apr. 2018, To Mar. 2019

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Medicinal Physical Chemistry Exercise 2

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Medicinal Physical Chemistry Seminar

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Basic Physical Chemistry II

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Physical Chemistry II (Electro- and Nano- Chemistry)

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Physical Chemistry IV (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Physical Chemistry 2 (Electro- and Interface- Chemistry)

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Medicinal Physical Chemistry Exercise 2

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Medicinal Physical Chemistry Seminar

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Basic Physical Chemistry I

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Physical Chemistry II (Electro- and Nano- Chemistry)

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Physical Chemistry IV (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Physical Chemistry 2 (Electro and Interface Chemistry)

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Physical Chemistry

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Physical Chemistry

  Fall, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Basic Physical Chemistry II

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Laboratory Practice in Basic Analytical Chemistry and Structural Biology

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Seminar in Basic Biophysical Chemistry

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Physical Chemistry II (Electro- and Nano- Chemistry)

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Physical Chemistry IV (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Physical Chemistry 4 (Biophysical Chemistry)

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Physical Chemistry 2 (Electro and Interface Chemistry)

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Research Training(Pharmaceutical and Biomedical Analysis)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科