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Fumihiko Kakizaki
Graduate School of Medicine Program-Specific Assistant Professor
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Last Updated :2025/06/14
Basic Information
Professional Memberships
- From Jan. 2025, To PresentJapanese Association for Metastasis Research
- From Sep. 2010, To PresentJapanese Cancer Association
Academic Degree
Academic Resume (Graduate Schools)
Research History
- From Oct. 2024, To PresentKyoto University, Graduate School of Medicine, Program-Specific Assistant Professor
- From Oct. 2019, To Sep. 2024Kyoto University, Hospital, Assistant Professor
- From Apr. 2019, To Sep. 2019Kyoto University, Hospital Gastrointestinal Surgery, 共同研究員（京ダイアグノスティクス株式会社）
- From Mar. 2017, To Apr. 2019Kyoto University, Graduate School of Medicine, AMED young researcher
- From Apr. 2014, To Mar. 2017Kyoto University, Graduate School of Medicine, Doctoral research fellow
- From Apr. 2011, To Mar. 2013Kyoto University, Graduate School of Medicine, Grobal COE program-specific researcher
- From Apr. 2010, To Mar. 2011Kyoto University, Graduate School of Medicine, Grobal COE program researcher
Profile
Profile
Research topic: Spread of disease by instigative cancer cells and the development of therapeutic methods
Research Overview: Normal cells progress to cancer cells via precancerous cells, traversing various pathological changes until ultimately leading to fatal outcomes in humans. This progression is a consequence of interactions between the influences exerted by cancer cells on their surrounding microenvironment and vice versa, spreading systemically. To investigate how cancer cells, originating from patients with diverse genetic backgrounds as well as different lifestyles and habits, develop their pathological characteristics, it is crucial to analyze cancer cells directly collected from each individual. Discovering the unique traits, weaknesses, malignancy, and other aspects of each cancer cell here will serve as leverage for the development of precision medicine through this research.
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ORCID ID
J-Global ID
Researcher number
00609076
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Last Updated :2025/06/14
Research
Research Interests
Research Areas
Papers
- Precision Oncology Framework Using Circulating Tumor CellsFumihiko Kakizaki; Kyoichi Oshiro; Yuya Enoki; Kana Kawanishi; Norikazu Masuda; Hisatsugu Maekawa; Jun Matsubayashi; Masahiro Kawashima; Hiroyuki Miyoshi; Yukitoshi Takemura; Kazutaka ObamaInternational Journal of Molecular Sciences, 10 Jun. 2025, Peer-reviewed, Invited
- Novel and efficient method for culturing patient-derived gastric cancer stem cells.Tomonori Morimoto; Yukitoshi Takemura; Takemitsu Miura; Takehito Yamamoto; Fumihiko Kakizaki; Hideo An; Hisatsugu Maekawa; Tadayoshi Yamaura; Kenji Kawada; Yoshiharu Sakai; Yoshiaki Yuba; Hiroaki Terajima; Kazutaka Obama; Makoto Mark Taketo; Hiroyuki MiyoshiCancer science, 20 May 2023, Peer-reviewed
- Efficacious Combination Drug Treatment for Colorectal Cancer that Overcomes Resistance to KRAS G12C Inhibitors.Hiroyuki Matsubara; Hiroyuki Miyoshi; Fumihiko Kakizaki; Tomonori Morimoto; Kenji Kawada; Takehito Yamamoto; Kazutaka Obama; Yoshiharu Sakai; Makoto Mark TaketoMolecular cancer therapeutics, 10 Feb. 2023, Peer-reviewed
- Chemosensitivity of Patient-Derived Cancer Stem Cells Identifies Colorectal Cancer Patients with Potential Benefit from FGFR Inhibitor TherapyTakehito Yamamoto; Hiroyuki Miyoshi; Fumihiko Kakizaki; Hisatsugu Maekawa; Tadayoshi Yamaura; Tomonori Morimoto; Toshiro Katayama; Kenji Kawada; Yoshiharu Sakai; M. Mark TaketoCancers, 22 Jul. 2020, Peer-reviewed
- Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells.Tadayoshi Yamaura; Hiroyuki Miyoshi; Hisatsugu Maekawa; Tomonori Morimoto; Takehito Yamamoto; Fumihiko Kakizaki; Koichiro Higasa; Kenji Kawada; Fumihiko Matsuda; Yoshiharu Sakai; M Mark TaketoOncotarget, 25 Dec. 2018, Peer-reviewed
- An improved method for culturing patient-derived colorectal cancer spheroids.Hiroyuki Miyoshi; Hisatsugu Maekawa; Fumihiko Kakizaki; Tadayoshi Yamaura; Kenji Kawada; Yoshiharu Sakai; M Mark TaketoOncotarget, 24 Apr. 2018, Peer-reviewed
- Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancerYoshiyuki Okada; Masahiro Sonoshita; Fumihiko Kakizaki; Naoki Aoyama; Yoshiro Itatani; Masayuki Uegaki; Hiromasa Sakamoto; Takashi Kobayashi; Takahiro Inoue; Tomomi Kamba; Akira Suzuki; Osamu Ogawa; M. Mark TaketoCancer Science, 01 Apr. 2017, Peer-reviewed
- Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2Fumihiko Kakizaki; Masahiro Sonoshita; Hiroyuki Miyoshi; Yoshiro Itatani; Shinji Ito; Kenji Kawada; Yoshiharu Sakai; M. Mark TaketoCANCER SCIENCE, Nov. 2016, Peer-reviewed
- Characterization of Aes nuclear foci in colorectal cancer cellsYoshiro Itatani; Masahiro Sonoshita; Fumihiko Kakizaki; Katsuya Okawa; Stefano Stifani; Hideaki Itoh; Yoshiharu Sakai; M. Mark TaketoJOURNAL OF BIOCHEMISTRY, Jan. 2016, Peer-reviewed
- Id2 deletion attenuates Apc-deficient ileal tumor formation.Kyoko Biyajima; Fumihiko Kakizaki; Xiaodong Shen; Kentaro Mori; Manabu Sugai; M Mark Taketo; Yoshifumi YokotaBiology open, 10 Jul. 2015, Peer-reviewed
- Promotion of Colorectal Cancer Invasion and Metastasis through Activation of NOTCH-DAB1-ABL-RHOGEF Protein TRIOMasahiro Sonoshita; Yoshiro Itatani; Fumihiko Kakizaki; Kenji Sakimura; Toshio Terashima; Yu Katsuyama; Yoshiharu Sakai; M. Mark TaketoCANCER DISCOVERY, Feb. 2015, Peer-reviewed
- Loss of SMAD4 From Colorectal Cancer Cells Promotes CCL15 Expression to Recruit CCR1(+) Myeloid Cells and Facilitate Liver MetastasisYoshiro Itatani; Kenji Kawada; Teruaki Fujishita; Fumihiko Kakizaki; Hideyo Hirai; Takuya Matsumoto; Masayoshi Iwamoto; Susumu Inamoto; Etsuro Hatano; Suguru Hasegawa; Taira Maekawa; Shinji Uemoto; Yoshiharu Sakai; Makoto Mark TaketoGASTROENTEROLOGY, Nov. 2013, Peer-reviewed
- Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch SignalingMasahiro Sonoshita; Masahiro Aoki; Haruhiko Fuwa; Koji Aoki; Hisahiro Hosogi; Yoshiharu Sakai; Hiroki Hashida; Arimichi Takabayashi; Makoto Sasaki; Sylvie Robine; Kazuyuki Itoh; Kiyoko Yoshioka; Fumihiko Kakizaki; Takanori Kitamura; Masanobu Oshima; Makoto Mark TaketoCANCER CELL, Jan. 2011, Peer-reviewed
- Suppression of Colonic Polyposis by Homeoprotein CDX2 through its Nontranscriptional Function that Stabilizes p27(Kip1)Koji Aoki; Fumihiko Kakizaki; Hiromi Sakashita; Toshiaki Manabe; Masahiro Aoki; Makoto M. TaketoCANCER RESEARCH, Jan. 2011, Peer-reviewed
- CDX Transcription Factors Positively Regulate Expression of Solute Carrier Family 5, Member 8 in the Colonic EpitheliumFumihiko Kakizaki; Koji Aoki; Hiroyuki Miyoshi; Nancy Carrasco; Masahiro Aoki; Makoto M. TaketoGASTROENTEROLOGY, Feb. 2010, Peer-reviewed
Misc.
- Japan Biodesign Association The Biodesigner Work Shop Completion (Organizer AMED)Dec. 2017
- AMINO-TERMINAL ENHANCER OF SPLIT/AES IS A TUMOR AND METASTASIS SUPPRESSOR OF PROSTATE CANCERYoshiyuki Okada; Fumihiko Kakizaki; Masayuki Uegaki; Takayuki Goto; Takeshi Yoshikawa; Naoki Terada; Takashi Kobayashi; Takahiro Inoue; Osamu Ogawa; Makoto TaketoJOURNAL OF UROLOGY, Apr. 2014
- SSSA-3-3 CCL15-CCRI axisによる大腸癌肝転移機序と,CCR1阻害薬による肝転移抑制への期待(SSSA Surgical Science and State of the Art,第113回日本外科学会定期学術集会)板谷 喜朗; 河田 健二; 藤下 晃章; 柿崎 文彦; 平位 秀世; 松本 卓也; 波多野 悦朗; 坂井 義治; 上本 伸二; 武藤 誠日本外科学会雑誌, 05 Mar. 2013
- 基礎と臨床消化器病学のレビュー 大腸癌マウスモデル—Mouse models of colon cancer青木 正博; 美谷島 杏子; 柿崎 文彦Review of gastroenterology & clinical gastroenterology and hepatology, Aug. 2009
Presentations
- Colorectal Cancer Stem Cell Transcriptome Can Affect Patient Prognostic OutcomeFumihiko KakizakiThe Eighth JCA-AACR Special Joint Conference, 29 Jun. 2024
- Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2Fumihiko KakizakiThe 76th Annual Meeting of Japanese Cancer Association, 28 Sep. 2017
- Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2Fumihiko KakizakiThe 2nd AMED Cancer Young Resercher Workshop, 29 Nov. 2016
- Transcription factor CDXs positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium (SLC5A8)Fumihiko KakizakiThe 33rd Annual Meeting of the Molecular Biology Society of Japan, 09 Dec. 2010
- Transcription factor CDXs positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium (SLC5A8)Fumihiko KakizakiThe 69st Annual Meeting of the Japanese Cancer Association, 23 Sep. 2010
- Transcription factor CDXs regulate expression of solute carrier family 5, member 8 in the colonic epithelium (SLC5A8)Fumihiko KakizakiThe 31st Annual Meeting of the Molecular Biology Society of Japan, 09 Dec. 2008
- Transcription factor CDXs regulate a candidate tumor suppressor gene SLC5A8Fumihiko KakizakiThe 9th Cancer Specific Group Young Researcher Workshop, Sep. 2008
- A male sterile mutation, ms(2)n55, affects sperm utilization by female, sperm entry into the egg and the male pronuclear formation.Kakizaki, F; Hara, M; Ohsako, T; Yamamoto, M46th A. Dros. Res. Conf., Mar. 2005
Awards
External funds: Kakenhi
- Studies on metastasis of colorectal cancer stem cells using clinical materials and mouse modelsGrant-in-Aid for Scientific Research (C)Basic Section 49030:Experimental pathology-relatedKyoto UniversityKakizaki FumihikoFrom 01 Apr. 2021, To 31 Mar. 2024, Project Closedがん幹細胞;TRIO;予後不良;大腸がん;がん転移;転移;マウスモデル
- Studies on digestive system cancer metastasis using mouse modelsGrant-in-Aid for Scientific Research (A)Kyoto UniversityMakoto TAKETOFrom 01 Apr. 2013, To 31 Mar. 2016, Project Closed消化器がん;浸潤;転移;予後マーカー;AES;NOTCH;ABL;TRIO;がん;消化器;ケモカイン;Notchシグナル;TGF-betaシグナル;予後診断;がん転移
- Studies on mechanisms of metastasis in colorectal cancer stem cell subtypes using mouse models and clinical materialsGrant-in-Aid for Scientific Research (C)Basic Section 49030:Experimental pathology-relatedKyoto University柿崎 文彦From 01 Apr. 2024, To 31 Mar. 2027, Grantedがん転移;がん幹細胞;マウスモデル;予後不良;トランスクリプトーム
