Search for faculty members
Fumihiko Kakizaki
Graduate School of Medicine Program-Specific Assistant Professor
list
Last Updated :2026/09/01
Basic Information
Professional Memberships
- From Jan. 2025, To PresentJapanese Association for Metastasis Research
- From Sep. 2010, To PresentJapanese Cancer Association
Academic Degree
Academic Resume (Graduate Schools)
Research History
- From Oct. 2024, To PresentKyoto University, Graduate School of Medicine, Department of Personalized Cancer Medicine, Assistant Professor (Specially Appointed)
- From Oct. 2019, To Sep. 2024Kyoto University, University Hospital, Institute of Advancement of Clinical and Translational Science, Assistant Professor
- From Apr. 2019, To Sep. 2019Kyo Diagnostics K.K., Employee (Seconded to the Department of Gastrointestinal Surgery, Kyoto University Hospital, as a Collaborative Researcher), 社員（京都大学 医学部附属病院 消化管外科 共同研究員として出向）
- From Apr. 2010, To Mar. 2019Kyoto University, Graduate School of Medicine, Postdoctoral Researcher (Conducted research as a Global COE Researcher, Global COE Specially Appointed Researcher, and AMED Young Researcher)
ID,URL
ORCID ID
J-Global ID
Researcher number
00609076
researchmap URL
list
Last Updated :2026/09/01
Research
Research Interests
Research Areas
- Life sciences, Tumor biology
- Life sciences, Cell biology
- Life sciences, Genomics
- Life sciences, Genetics
- Life sciences, Molecular biology
- Life sciences, Experimental pathology
Papers
- Involvement of tyrosine phosphatase PTPROt in acquired resistance to FGFR inhibitor therapy in colorectal cancer.Shoichi Kitano; Hiroyuki Miyoshi; Takehito Yamamoto; Hiroyuki Matsubara; Tomonori Morimoto; Fumihiko Kakizaki; Kenji Kawada; Kazutaka Obama; Yoshiharu Sakai; Makoto Mark TaketoMolecular cancer therapeutics, 15 Jun. 2026
- Comprehensive Colorectal Cancer Stem Cell Transcriptomic Signatures That Can Predict Patient Prognostic Outcomes.Fumihiko Kakizaki; Hiroyuki Miyoshi; Takehito Yamamoto; Tomonori Morimoto; Hiroyuki Matsubara; Shoichi Kitano; Tadayoshi Yamaura; Hisatsugu Maekawa; J B Brown; Tosiya Shun Sato; Kazutaka Obama; Yoshiharu Sakai; Kenji Kawada; Makoto Mark TaketoCancer science, 31 Oct. 2025, Peer-reviewed
- Monoclonal antibody for phosphorylated TRIO Y2681 that helps predict prognosis of post-operative colorectal cancer patients.Taro Aoyama; Fumihiko Kakizaki; Hiroyuki Miyoshi; Masahiro Sonoshita; Hisatsugu Maekawa; Yoshiro Itatani; Kenji Kawada; Ryo Matsusue; Iwao Ikai; Koki Moriyoshi; Takaki Sakurai; Kazutaka Obama; Tosiya Shun Sato; Yoshiharu Sakai; Makoto Mark TaketoBJC reports, 25 Jul. 2025, Peer-reviewed
- Precision Oncology Framework Using Circulating Tumor CellsFumihiko Kakizaki; Kyoichi Oshiro; Yuya Enoki; Kana Kawanishi; Norikazu Masuda; Hisatsugu Maekawa; Jun Matsubayashi; Masahiro Kawashima; Hiroyuki Miyoshi; Yukitoshi Takemura; Kazutaka ObamaInternational Journal of Molecular Sciences, 10 Jun. 2025, Peer-reviewed, Invited
- Novel and efficient method for culturing patient-derived gastric cancer stem cells.Tomonori Morimoto; Yukitoshi Takemura; Takemitsu Miura; Takehito Yamamoto; Fumihiko Kakizaki; Hideo An; Hisatsugu Maekawa; Tadayoshi Yamaura; Kenji Kawada; Yoshiharu Sakai; Yoshiaki Yuba; Hiroaki Terajima; Kazutaka Obama; Makoto Mark Taketo; Hiroyuki MiyoshiCancer science, 20 May 2023, Peer-reviewed
- Efficacious Combination Drug Treatment for Colorectal Cancer that Overcomes Resistance to KRAS G12C Inhibitors.Hiroyuki Matsubara; Hiroyuki Miyoshi; Fumihiko Kakizaki; Tomonori Morimoto; Kenji Kawada; Takehito Yamamoto; Kazutaka Obama; Yoshiharu Sakai; Makoto Mark TaketoMolecular cancer therapeutics, 10 Feb. 2023, Peer-reviewed
- Chemosensitivity of Patient-Derived Cancer Stem Cells Identifies Colorectal Cancer Patients with Potential Benefit from FGFR Inhibitor TherapyTakehito Yamamoto; Hiroyuki Miyoshi; Fumihiko Kakizaki; Hisatsugu Maekawa; Tadayoshi Yamaura; Tomonori Morimoto; Toshiro Katayama; Kenji Kawada; Yoshiharu Sakai; M. Mark TaketoCancers, 22 Jul. 2020, Peer-reviewed
- Accurate diagnosis of mismatch repair deficiency in colorectal cancer using high-quality DNA samples from cultured stem cells.Tadayoshi Yamaura; Hiroyuki Miyoshi; Hisatsugu Maekawa; Tomonori Morimoto; Takehito Yamamoto; Fumihiko Kakizaki; Koichiro Higasa; Kenji Kawada; Fumihiko Matsuda; Yoshiharu Sakai; M Mark TaketoOncotarget, 25 Dec. 2018, Peer-reviewed
- An improved method for culturing patient-derived colorectal cancer spheroids.Hiroyuki Miyoshi; Hisatsugu Maekawa; Fumihiko Kakizaki; Tadayoshi Yamaura; Kenji Kawada; Yoshiharu Sakai; M Mark TaketoOncotarget, 24 Apr. 2018, Peer-reviewed
- Amino-terminal enhancer of split gene AES encodes a tumor and metastasis suppressor of prostate cancerYoshiyuki Okada; Masahiro Sonoshita; Fumihiko Kakizaki; Naoki Aoyama; Yoshiro Itatani; Masayuki Uegaki; Hiromasa Sakamoto; Takashi Kobayashi; Takahiro Inoue; Tomomi Kamba; Akira Suzuki; Osamu Ogawa; M. Mark TaketoCancer Science, 01 Apr. 2017, Peer-reviewed
- Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2Fumihiko Kakizaki; Masahiro Sonoshita; Hiroyuki Miyoshi; Yoshiro Itatani; Shinji Ito; Kenji Kawada; Yoshiharu Sakai; M. Mark TaketoCANCER SCIENCE, Nov. 2016, Peer-reviewed
- Characterization of Aes nuclear foci in colorectal cancer cellsYoshiro Itatani; Masahiro Sonoshita; Fumihiko Kakizaki; Katsuya Okawa; Stefano Stifani; Hideaki Itoh; Yoshiharu Sakai; M. Mark TaketoJOURNAL OF BIOCHEMISTRY, Jan. 2016, Peer-reviewed
- Id2 deletion attenuates Apc-deficient ileal tumor formation.Kyoko Biyajima; Fumihiko Kakizaki; Xiaodong Shen; Kentaro Mori; Manabu Sugai; M Mark Taketo; Yoshifumi YokotaBiology open, 10 Jul. 2015, Peer-reviewed
- Promotion of Colorectal Cancer Invasion and Metastasis through Activation of NOTCH-DAB1-ABL-RHOGEF Protein TRIOMasahiro Sonoshita; Yoshiro Itatani; Fumihiko Kakizaki; Kenji Sakimura; Toshio Terashima; Yu Katsuyama; Yoshiharu Sakai; M. Mark TaketoCANCER DISCOVERY, Feb. 2015, Peer-reviewed
- Loss of SMAD4 From Colorectal Cancer Cells Promotes CCL15 Expression to Recruit CCR1(+) Myeloid Cells and Facilitate Liver MetastasisYoshiro Itatani; Kenji Kawada; Teruaki Fujishita; Fumihiko Kakizaki; Hideyo Hirai; Takuya Matsumoto; Masayoshi Iwamoto; Susumu Inamoto; Etsuro Hatano; Suguru Hasegawa; Taira Maekawa; Shinji Uemoto; Yoshiharu Sakai; Makoto Mark TaketoGASTROENTEROLOGY, Nov. 2013, Peer-reviewed
- Suppression of Colon Cancer Metastasis by Aes through Inhibition of Notch SignalingMasahiro Sonoshita; Masahiro Aoki; Haruhiko Fuwa; Koji Aoki; Hisahiro Hosogi; Yoshiharu Sakai; Hiroki Hashida; Arimichi Takabayashi; Makoto Sasaki; Sylvie Robine; Kazuyuki Itoh; Kiyoko Yoshioka; Fumihiko Kakizaki; Takanori Kitamura; Masanobu Oshima; Makoto Mark TaketoCANCER CELL, Jan. 2011, Peer-reviewed
- Suppression of Colonic Polyposis by Homeoprotein CDX2 through its Nontranscriptional Function that Stabilizes p27(Kip1)Koji Aoki; Fumihiko Kakizaki; Hiromi Sakashita; Toshiaki Manabe; Masahiro Aoki; Makoto M. TaketoCANCER RESEARCH, Jan. 2011, Peer-reviewed
- CDX Transcription Factors Positively Regulate Expression of Solute Carrier Family 5, Member 8 in the Colonic EpitheliumFumihiko Kakizaki; Koji Aoki; Hiroyuki Miyoshi; Nancy Carrasco; Masahiro Aoki; Makoto M. TaketoGASTROENTEROLOGY, Feb. 2010, Peer-reviewed
Misc.
- Japan Biodesign Association The Biodesigner Work Shop Completion (Organizer AMED)Dec. 2017
- AMINO-TERMINAL ENHANCER OF SPLIT/AES IS A TUMOR AND METASTASIS SUPPRESSOR OF PROSTATE CANCERYoshiyuki Okada; Fumihiko Kakizaki; Masayuki Uegaki; Takayuki Goto; Takeshi Yoshikawa; Naoki Terada; Takashi Kobayashi; Takahiro Inoue; Osamu Ogawa; Makoto TaketoJOURNAL OF UROLOGY, Apr. 2014
- SSSA-3-3 CCL15-CCRI axisによる大腸癌肝転移機序と,CCR1阻害薬による肝転移抑制への期待(SSSA Surgical Science and State of the Art,第113回日本外科学会定期学術集会)板谷 喜朗; 河田 健二; 藤下 晃章; 柿崎 文彦; 平位 秀世; 松本 卓也; 波多野 悦朗; 坂井 義治; 上本 伸二; 武藤 誠日本外科学会雑誌, 05 Mar. 2013
- 基礎と臨床消化器病学のレビュー 大腸癌マウスモデル—Mouse models of colon cancer青木 正博; 美谷島 杏子; 柿崎 文彦Review of gastroenterology & clinical gastroenterology and hepatology, Aug. 2009
Presentations
- Development of a Diagnostic Method Using Circulating Tumor Cells (CTCs)Fumihiko Kakizaki; Kyoichi Oshiro; Yuya Enoki; Masahiro Kawashima; Kana Kawanishi; Takehito Yamamoto; Jun Matsubayashi; Norikazu Masuda; Hiroyuki Miyoshi; Yukitoshi Takemura; Kazutaka ObamaJapanese Society of the Study of Liquid Biopsy, 06 Feb. 2026
- Ongoing Efforts for Long-Term Expansion of Circulating Tumor 10614 Cells (CTCs)Fumihiko Kakizaki; Kyoichi Oshiro; Yuya Enoki; Kana Kawanishi; Norikazu Masuda; Hisatsugu Maekawa; Jun Matsubayashi; Masahiro Kawashima; Hiroyuki Miyoshi; Yukitoshi Takemura; Kazutaka ObamaThe 84th Annual Meeting of the Japanese Cancer Association, 25 Sep. 2025
- Heterogeneity of Circulating Tumor Cells (CTC)Fumihiko Kakizaki; Kyoichi Oshiro; Kana Kawanishi; Norikazu Masuda; Hisatsugu Maekawa; Jun Matsubayashi; Masahiro Kawashima; Hiroyuki Miyoshi; Yukitoshi Takemura; Kazutaka ObamaThe 34th Annual Meeting of the Japanese Association for Metastasis Research, 19 Jun. 2025
- Colorectal Cancer Stem Cell Transcriptome Can Affect Patient Prognostic OutcomeFumihiko Kakizaki; Makoto Mark TaketoThe Eighth JCA-AACR Special Joint Conference, 29 Jun. 2024
- Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2Fumihiko Kakizaki; Masahiro Sonoshita; Hiroyuki Miyoshi; Yoshiro Itatani; Shinji Ito; Kenji Kawada; Yoshiharu Sakai; M. Mark TaketoThe 76th Annual Meeting of Japanese Cancer Association, 28 Sep. 2017
- Expression of metastasis suppressor gene AES driven by a Yin Yang (YY) element in a CpG island promoter and transcription factor YY2Fumihiko KakizakiThe 2nd AMED Cancer Young Resercher Workshop, 29 Nov. 2016
- Transcription factor CDXs positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium (SLC5A8)Fumihiko KakizakiThe 33rd Annual Meeting of the Molecular Biology Society of Japan, 09 Dec. 2010
- Transcription factor CDXs positively regulate expression of solute carrier family 5, member 8 in the colonic epithelium (SLC5A8)Fumihiko KakizakiThe 69st Annual Meeting of the Japanese Cancer Association, 23 Sep. 2010
- Transcription factor CDXs regulate expression of solute carrier family 5, member 8 in the colonic epithelium (SLC5A8)Fumihiko KakizakiThe 31st Annual Meeting of the Molecular Biology Society of Japan, 09 Dec. 2008
- Transcription factor CDXs regulate a candidate tumor suppressor gene SLC5A8Fumihiko KakizakiThe 9th Cancer Specific Group Young Researcher Workshop, Sep. 2008
- A male sterile mutation, ms(2)n55, affects sperm utilization by female, sperm entry into the egg and the male pronuclear formation.Kakizaki, F; Hara, M; Ohsako, T; Yamamoto, M46th A. Dros. Res. Conf., Mar. 2005
Awards
External funds: Kakenhi
- Studies on metastasis of colorectal cancer stem cells using clinical materials and mouse modelsGrant-in-Aid for Scientific Research (C)Basic Section 49030:Experimental pathology-relatedKyoto UniversityKakizaki FumihikoFrom 01 Apr. 2021, To 31 Mar. 2024, Project Closedがん幹細胞;TRIO;予後不良;大腸がん;がん転移;転移;マウスモデル
- Studies on digestive system cancer metastasis using mouse modelsGrant-in-Aid for Scientific Research (A)Kyoto UniversityMakoto TAKETOFrom 01 Apr. 2013, To 31 Mar. 2016, Project Closed消化器がん;浸潤;転移;予後マーカー;AES;NOTCH;ABL;TRIO;がん;消化器;ケモカイン;Notchシグナル;TGF-betaシグナル;予後診断;がん転移
- Studies on mechanisms of metastasis in colorectal cancer stem cell subtypes using mouse models and clinical materialsGrant-in-Aid for Scientific Research (C)Basic Section 49030:Experimental pathology-relatedKyoto University柿崎 文彦From 01 Apr. 2024, To 31 Mar. 2027, Granted転移;病理像;トランスクリプトーム;細胞機能;タンパクリン酸化;がん転移;がん幹細胞;マウスモデル;予後不良
