Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医学専攻 免疫制御学, 教授
• Graduate School of Medicine, 医科学専攻 免疫制御学, 教授
• Graduate School of Pharmaceutical Sciences, 薬科学専攻 免疫防御学, 教授

Email Address

• Email Address

  ikuta.koichi.6ckyoto-u.ac.jp

Professional Memberships

• 日本生化学会
• 日本分子生物学会
• 日本免疫学会

Academic Degree

• 医学博士(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院医学研究科博士課程転入学, 修了

Academic Resume (Undergraduate School/Majors)

• 東京大学, 医学部医学科, 卒業

Research History

• From Apr. 2022, To Present

  Kyoto University, Institute for Life and Medical Institute, Professor
• From Oct. 2016, To Mar. 2022

  Kyoto University, Institute for Frontier Life and Medical Sciences, Professor
• From Apr. 2002, To Sep. 2016

  Kyoto University, Institute for Virus Research, Professor
• From Jul. 1996, To Mar. 2002

  Kyoto University, Graduate School of Medicine, Associate Professor
• From Mar. 1992, To Mar. 1997

  The University of Tokyo, Faculty of Medicine, Visiting Associate Professor
• From Jan. 1990, To Feb. 1992

  Stanford University, Howard Hughes Medical Institute, School of Medicine, Research Associate
• From Jan. 1988, To Jan. 1990

  Stanford University, Department of Pathology, School of Medicine, Postdoctoral Fellow
• From May 1987, To Jan. 1988

  Kumamoto University, Research Center for Immunology and Medicine, School of Medicine, Assistant Professor
• From Apr. 1987, To Apr. 1987

  Kyoto University, Hospital, Clinical Fellow

Language of Instruction

• English

ID,URL

• ORCID ID

  0000-0003-1319-1021

• J-Global ID

  200901080152924358

• External link

  https://www2.infront.kyoto-u.ac.jp/Ikuta-Lab/

Website(s) (URL(s))

• https://www2.infront.kyoto-u.ac.jp/Ikuta-Lab/

researchmap URL

• https://researchmap.jp/read0051944

Research

Research Topics, Overview of the research

• Research Topics

  Function of IL-7 receptor (IL-7R) in immune system; regulation of immune response by IL-7R expression; distribution and function of cytokine-producing cells in lymphoid organs; control of immune system by steroid hormones; circadian control of immune system; and sex difference in immunity

• Overview of the research

  I have found that fetal and adult hematopoietic stem cells have different developmental potential to differentiate into lymphocytes. I have also demonstrated that interleukin-7 (IL-7) controls DNA recombination of lymphocyte antigen receptor genes by changing chromatin structures. Based on these findings, I am now pursuing research on development of the immune system and regulation of immune responses by IL-7.

Research Interests

• innate lymphoid cell
• innate-like lymphocyte
• glucocorticoid
• sex hormone
• circadian rhythm
• lymphocyte
• microenvironment
• IL-7 receptor
• cytokine receptor
• cytokine

Research Areas

• Life sciences, Immunology
• Life sciences, Pathobiochemistry
• Life sciences, Medical biochemistry

Papers

• The transcription factor RORα is required for the development of type 1 innate lymphoid cells in adult bone marrow

  Shinya Abe; Moe Kagao; Takuma Asahi; Ryoma Kato; Shizue Tani-ichi; Akihiro Shimba; Riki Ishibashi; Hitoshi Miyachi; Satsuki Kitano; Masaki Miyazaki; Hans-Reimer Rodewald; Fumiko Toyoshima; Koichi Ikuta

  The Journal of Immunology, 13 Mar. 2025

  
• A feedback amplifier circuit with Notch and E2A orchestrates T-cell fate and suppresses the innate lymphoid cell lineages during thymic ontogeny.

  Kazuko Miyazaki; Kenta Horie; Hitomi Watanabe; Reiko Hidaka; Rinako Hayashi; Norihito Hayatsu; Kentaro Fujiwara; Rei Kuwata; Takuya Uehata; Yotaro Ochi; Makoto Takenaka; Risa Karakida Kawaguchi; Koichi Ikuta; Osamu Takeuchi; Seishi Ogawa; Katsuto Hozumi; Georg A Holländer; Gen Kondoh; Taishin Akiyama; Masaki Miyazaki

  Genes & development, 04 Feb. 2025

  
• A Chimeric IL-7Rα/IL-2Rβ Receptor Promotes the Differentiation of T Cell Progenitors into B Cells and Type 2 Innate Lymphoid Cells.

  Akihiro Shimba; Shizue Tani-Ichi; Kyoko Masuda; Guangwei Cui; Satoru Munakata; Shinya Abe; Satsuki Kitano; Hitoshi Miyachi; Hiroshi Kawamoto; Koichi Ikuta

  Journal of immunology (Baltimore, Md. : 1950), 14 Aug. 2024

  
• A RORE-dependent Intronic Enhancer in the IL-7 Receptor-α Locus Controls Glucose Metabolism via Vγ4+ γδT17 Cells

  Shizue Tani-ichi; David Obwegs; Alice Yoshikawa; Hitomi Watanabe; Satsuki Kitano; Aki Ejima; Shinya Hatano; Hitoshi Miyachi; Guangwei Cui; Akihiro Shimba; Shinya Abe; Shohei Hori; Gen Kondoh; Sagar; Yasunobu Yoshikai; Koichi Ikuta

  The Journal of Immunology, 12 Jun. 2024

  
• Control of the Development, Distribution, and Function of Innate-Like Lymphocytes and Innate Lymphoid Cells by the Tissue Microenvironment.

  Koichi Ikuta; Takuma Asahi; Guangwei Cui; Shinya Abe; Daichi Takami

  Advances in experimental medicine and biology, 2024

  
• Insights into the heterogeneity of iNKT cells: tissue-resident and circulating subsets shaped by local microenvironmental cues.

  Guangwei Cui; Shinya Abe; Ryoma Kato; Koichi Ikuta

  Frontiers in immunology, 2024

  
• Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow.

  Shinya Abe; Takuma Asahi; Takahiro Hara; Guangwei Cui; Akihiro Shimba; Shizue Tani-Ichi; Kohei Yamada; Kazuko Miyazaki; Hitoshi Miyachi; Satsuki Kitano; Naotoshi Nakamura; Junichi Kikuta; Alexis Vandenbon; Masaki Miyazaki; Ryo Yamada; Toshiaki Ohteki; Masaru Ishii; Veronika Sexl; Takashi Nagasawa; Koichi Ikuta

  Cell reports, 10 Sep. 2023

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• CD45 alleviates airway inflammation and lung fibrosis by limiting expansion and activation of ILC2s.

  Guangwei Cui; Akihiro Shimba; Jianshi Jin; Nozomi Hojo; Takuma Asahi; Shinya Abe; Aki Ejima; Shinri Okada; Keizo Ohira; Ryoma Kato; Shizue Tani-Ichi; Ryo Yamada; Takashi Ebihara; Katsuyuki Shiroguchi; Koichi Ikuta

  Proceedings of the National Academy of Sciences of the United States of America, 05 Sep. 2023

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• Author Correction: Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies.

  Emily R Kansler; Saïda Dadi; Chirag Krishna; Briana G Nixon; Efstathios G Stamatiades; Ming Liu; Fengshen Kuo; Jing Zhang; Xian Zhang; Kristelle Capistrano; Kyle A Blum; Kate Weiss; Ross M Kedl; Guangwei Cui; Koichi Ikuta; Timothy A Chan; Christina S Leslie; A Ari Hakimi; Ming O Li

  Nature immunology, Aug. 2022

  
• Lung group 2 innate lymphoid cells differentially depend on local IL-7 for their distribution, activation, and maintenance in innate and adaptive immunity-mediated airway inflammation.

  Daichi Takami; Shinya Abe; Akihiro Shimba; Takuma Asahi; Guangwei Cui; Shizue Tani-Ichi; Takahiro Hara; Keishi Miyata; Masashi Ikutani; Kiyoshi Takatsu; Yuichi Oike; Koichi Ikuta

  International immunology, 26 Jul. 2023

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• 肺における2型自然リンパ球の維持と活性化に対するIL-7の機能(Role of local IL-7 in maintenance and activation of lung ILC2)

  高見 大地; 阿部 真也; 榛葉 旭恒; 旭 拓真; 生田 宏一

  日本細胞生物学会大会講演要旨集, Jun. 2020

  
• Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches.

  Takuma Asahi; Shinya Abe; Guangwei Cui; Akihiro Shimba; Tsukasa Nabekura; Hitoshi Miyachi; Satsuki Kitano; Keizo Ohira; Johannes M Dijkstra; Masaki Miyazaki; Akira Shibuya; Hiroshi Ohno; Koichi Ikuta

  eLife, 22 Jun. 2023

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• Retinoic acid receptor activity is required for the maintenance of type 1 innate lymphoid cells

  Takuma Asahi; Shinya Abe; Yuya Tajika; Hans-Reimer Rodewald; Veronika Sexl; Hiroshi Takeshima; Koichi Ikuta

  International Immunology, 08 Dec. 2022, Peer-reviewed, Last author, Corresponding author

  
• Physiological concentrations of glucocorticoids induce pathological DNA double‐strand breaks

  Salma Akter; Akihiro Shimba; Koichi Ikuta; Md. Rasel Al Mahmud; Shintaro Yamada; Hiroyuki Sasanuma; Masataka Tsuda; Masakatsu Sone; Yukio Ago; Kenichi Murai; Hisashi Tanaka; Shunichi Takeda

  Genes to Cells, 07 Dec. 2022, Peer-reviewed

  
• Control of immunity and allergy by steroid hormones

  Koichi Ikuta; Aki Ejima; Shinya Abe; Akihiro Shimba

  Allergology International, Oct. 2022, Invited, Lead author, Corresponding author

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• Interleukin-7 receptor signaling is crucial for enhancer-dependent TCRδ germline transcription mediated through STAT5 recruitment

  Alonso Rodríguez-Caparrós; Shizue Tani-ichi; Áurea Casal; Jennifer López-Ros; Carlos Suñé; Koichi Ikuta; Cristina Hernández-Munain

  Frontiers in Immunology, 19 Aug. 2022, Peer-reviewed

  
• A circulating subset of iNKT cells mediates antitumor and antiviral immunity.

  Guangwei Cui; Akihiro Shimba; Jianshi Jin; Taisaku Ogawa; Yukiko Muramoto; Hitoshi Miyachi; Shinya Abe; Takuma Asahi; Shizue Tani-Ichi; Johannes M Dijkstra; Yayoi Iwamoto; Kirill Kryukov; Yuanbo Zhu; Daichi Takami; Takahiro Hara; Satsuki Kitano; Yan Xu; Hajime Morita; Moyu Zhang; Lynn Zreka; Keishi Miyata; Takashi Kanaya; Shinya Okumura; Takashi Ito; Etsuro Hatano; Yoshimasa Takahashi; Hiroshi Watarai; Yuichi Oike; Tadashi Imanishi; Hiroshi Ohno; Toshiaki Ohteki; Nagahiro Minato; Masato Kubo; Georg A Holländer; Hideki Ueno; Takeshi Noda; Katsuyuki Shiroguchi; Koichi Ikuta

  Science immunology, 28 Oct. 2022, Peer-reviewed, Last author, Corresponding author

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• Androgens Alleviate Allergic Airway Inflammation by Suppressing Cytokine Production in Th2 Cells.

  Aki Ejima; Shinya Abe; Akihiro Shimba; Susumu Sato; Takuya Uehata; Shizue Tani-Ichi; Satoru Munakata; Guangwei Cui; Osamu Takeuchi; Toyohiro Hirai; Shigeaki Kato; Koichi Ikuta

  Journal of immunology (Baltimore, Md. : 1950), 17 Aug. 2022, Peer-reviewed, Last author, Corresponding author

  
• Cytotoxic innate lymphoid cells sense cancer cell-expressed interleukin-15 to suppress human and murine malignancies.

  Emily R Kansler; Saïda Dadi; Chirag Krishna; Briana G Nixon; Efstathios G Stamatiades; Ming Liu; Fengshen Kuo; Jing Zhang; Xian Zhang; Kristelle Capistrano; Kyle A Blum; Kate Weiss; Ross M Kedl; Guangwei Cui; Koichi Ikuta; Timothy A Chan; Christina S Leslie; A Ari Hakimi; Ming O Li

  Nature immunology, Jun. 2022, Peer-reviewed

  
• Estradiol suppresses psoriatic inflammation in mice by regulating neutrophil and macrophage functions.

  Akimasa Adachi; Tetsuya Honda; Gyohei Egawa; Shuto Kanameishi; Riko Takimoto; Toshiya Miyake; Md Razib Hossain; Mayumi Komine; Mamitaro Ohtsuki; Matthias Gunzer; Koichi Ikuta; Kenji Kabashima

  The Journal of allergy and clinical immunology, 04 May 2022, Peer-reviewed

  
• IRF4 deficiency vulnerates B-cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity.

  Dennis Das Gupta; Christoph Paul; Nadine Samel; Maria Bieringer; Daniel Staudenraus; Federico Marini; Hartmann Raifer; Lisa Menke; Lea Hansal; Bärbel Camara; Edith Roth; Patrick Daum; Michael Wanzel; Marco Mernberger; Andrea Nist; Uta-Maria Bauer; Frederik Helmprobst; Malte Buchholz; Katrin Roth; Lorenz Bastian; Alina M Hartmann; Claudia Baldus; Koichi Ikuta; Andreas Neubauer; Andreas Burchert; Hans-Martin Jäck; Matthias Klein; Tobias Bopp; Thorsten Stiewe; Axel Pagenstecher; Michael Lohoff

  Cell death and differentiation, 22 Apr. 2022, Peer-reviewed

  
• Fate of adipocyte progenitors during adipogenesis in mice fed a high-fat diet

  Muhammad Bilal; Allah Nawaz; Tomonobu Kado; Muhammad Rahil Aslam; Yoshiko Igarashi; Ayumi Nishimura; Yoshiyuki Watanabe; Takahide Kuwano; Jianhui Liu; Hiroyuki Miwa; Takumi Era; Koichi Ikuta; Johji Imura; Kunimasa Yagi; Takashi Nakagawa; Shiho Fujisaka; Kazuyuki Tobe

  Molecular Metabolism, Sep. 2021, Peer-reviewed

  
• IL-4-Producing Vγ1+/Vδ6+ γδ T Cells Sustain Germinal Center Reactions in Peyer's Patches of Mice.

  Leon Ullrich; Yvonne Lueder; Anna-Lena Juergens; Anneke Wilharm; Joana Barros-Martins; Anja Bubke; Abdi Demera; Koichi Ikuta; Gwendolyn Elena Patzer; Anika Janssen; Inga Sandrock; Immo Prinz; Francesca Rampoldi

  Frontiers in immunology, 2021, Peer-reviewed

  
• High-throughput identification and quantification of single bacterial cells in the microbiota.

  Jianshi Jin; Reiko Yamamoto; Tadashi Takeuchi; Guangwei Cui; Eiji Miyauchi; Nozomi Hojo; Koichi Ikuta; Hiroshi Ohno; Katsuyuki Shiroguchi

  Nature communications, 22 Feb. 2022, Peer-reviewed

  
• The Roles of IL-7 and IL-15 in Niches for Lymphocyte Progenitors and Immune Cells in Lymphoid Organs.

  Koichi Ikuta; Takahiro Hara; Shinya Abe; Takuma Asahi; Daichi Takami; Guangwei Cui

  Current topics in microbiology and immunology, 2021, Invited

  
• Lymph Node Stromal Cells: Diverse Meshwork Structures Weave Functionally Subdivided Niches.

  Arata Takeuchi; Madoka Ozawa; Guangwei Cui; Koichi Ikuta; Tomoya Katakai

  Current topics in microbiology and immunology, 2021, Invited

  
• Cell wall N-glycan of Candida albicans ameliorates early hyper- and late hypo-immunoreactivity in sepsis

  Masataka Kawakita; Taiki Oyama; Ikuma Shirai; Shuto Tanaka; Kotaro Akaki; Shinya Abe; Takuma Asahi; Guangwei Cui; Fumie Itoh; Masato Sasaki; Nobuyuki Shibata; Koichi Ikuta; Tomomitsu Hatakeyama; Kazuhiko Takahara

  Communications Biology, Dec. 2021, Peer-reviewed

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• Prolonged high-intensity exercise induces fluctuating immune responses to herpes simplex virus infection via glucocorticoids

  Akimasa Adachi; Tetsuya Honda; Teruki Dainichi; Gyohei Egawa; Yosuke Yamamoto; Takashi Nomura; Saeko Nakajima; Atsushi Otsuka; Masamitsu Maekawa; Nariyasu Mano; Naoto Koyanagi; Yasushi Kawaguchi; Toshiaki Ohteki; Takashi Nagasawa; Koichi Ikuta; Akihiko Kitoh; Kenji Kabashima

  Journal of Allergy and Clinical Immunology, May 2021, Peer-reviewed

  
• Generation and characterization of a Meflin-CreERT2 transgenic line for lineage tracing in white adipose tissue

  Takahide Kuwano; Hironori Izumi; Muhammad Rahil Aslam; Yoshiko Igarashi; Muhammad Bilal; Ayumi Nishimura; Yoshiyuki Watanabe; Allah Nawaz; Tomonobu Kado; Koichi Ikuta; Seiji Yamamoto; Masakiyo Sasahara; Shiho Fujisaka; Kunimasa Yagi; Hisashi Mori; Kazuyuki Tobe

  PLOS ONE, 24 Mar. 2021, Peer-reviewed

  
• Control of immunity by glucocorticoids in health and disease

  Akihiro Shimba; Koichi Ikuta

  Seminars in Immunopathology, Dec. 2020, Peer-reviewed, Invited

  
• Immune-enhancing effects of glucocorticoids in response to day–night cycles and stress

  Akihiro Shimba; Koichi Ikuta

  International Immunology, 20 Oct. 2020, Invited

  
• Glucocorticoids regulate circadian rhythm of innate and adaptive immunity

  Akihiro Shimba; Koichi Ikuta

  Frontiers in Immunology, 18 Sep. 2020, Peer-reviewed, Invited

  
• The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells

  Kazuko Miyazaki; Hitomi Watanabe; Genki Yoshikawa; Kenian Chen; Reiko Hidaka; Yuki Aitani; Kai Osawa; Rie Takeda; Yotaro Ochi; Shizue Tani-ichi; Takuya Uehata; Osamu Takeuchi; Koichi Ikuta; Seishi Ogawa; Gen Kondoh; Yin C. Lin; Hiroyuki Ogata; Masaki Miyazaki

  Science Immunology, 04 Sep. 2020, Peer-reviewed

  
• Innate-like CD27+CD45RBhigh γδ T Cells Require TCR Signaling for Homeostasis in Peripheral Lymphoid Organs.

  Shizue Tani-Ichi; Keisuke Wagatsuma; Takahiro Hara; Guangwei Cui; Shinya Abe; Hitoshi Miyachi; Satsuki Kitano; Koichi Ikuta

  Journal of immunology (Baltimore, Md. : 1950), 15 May 2020, Peer-reviewed

  
• Intestinal epithelial cell-derived IL-15 determines local maintenance and maturation of intra-epithelial lymphocytes in the intestine.

  Yuanbo Zhu; Guangwei Cui; Eiji Miyauchi; Yuki Nakanishi; Hisa Mukohira; Akihiro Shimba; Shinya Abe; Shizue Tani-Ichi; Takahiro Hara; Hiroshi Nakase; Tsutomu Chiba; Atsuko Sehara-Fujisawa; Hiroshi Seno; Hiroshi Ohno; Koichi Ikuta

  International immunology, 08 May 2020, Peer-reviewed

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• IL-7R-Dependent Phosphatidylinositol 3-Kinase Competes with the STAT5 Signal to Modulate T Cell Development and Homeostasis.

  Guangwei Cui; Akihiro Shimba; Guangyong Ma; Kazuhiko Takahara; Shizue Tani-Ichi; Yuanbo Zhu; Takuma Asahi; Akifumi Abe; Hitoshi Miyachi; Satsuki Kitano; Takahiro Hara; Jun-Ichirou Yasunaga; Hirotsugu Suwanai; Hisakata Yamada; Masao Matsuoka; Kohjiro Ueki; Yasunobu Yoshikai; Koichi Ikuta

  Journal of immunology (Baltimore, Md. : 1950), 15 Feb. 2020, Peer-reviewed

  
• Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice.

  Hitoshi Inokawa; Yasuhiro Umemura; Akihiro Shimba; Eiryo Kawakami; Nobuya Koike; Yoshiki Tsuchiya; Munehiro Ohashi; Yoichi Minami; Guangwei Cui; Takuma Asahi; Ryutaro Ono; Yuh Sasawaki; Eiichi Konishi; Seung-Hee Yoo; Zheng Chen; Satoshi Teramukai; Koichi Ikuta; Kazuhiro Yagita

  Scientific reports, 13 Feb. 2020, Peer-reviewed

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• Mesenchymal stromal cells in bone marrow express adiponectin and are efficiently targeted by an adiponectin promoter-driven Cre transgene.

  Hisa Mukohira; Takahiro Hara; Shinya Abe; Shizue Tani-Ichi; Atsuko Sehara-Fujisawa; Takashi Nagasawa; Kazuyuki Tobe; Koichi Ikuta

  International immunology, 16 Oct. 2019, Peer-reviewed

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• Notch signaling controls transcription via the recruitment of RUNX1 and MYB to enhancers during T cell development

  Rodríguez-Caparrós, A; García, V; Casal, Á; López-Ros, J; García-Mariscal, A; Tani-ichi, S; Ikuta, K; Hernández-Munain, C

  J. Immunol., 2019, Peer-reviewed

  
• Tissue maintenance of CMV-specific inflationary memory T cells by IL-15

  Nicolas S. Baumann; Nicole Torti; Suzanne P. M. Welten; Isabel Barnstorf; Mariana Borsa; Katharina Pallmer; Jennifer D. Oduro; Luka Cicin-Sain; Koichi Ikuta; Burkhard Ludewig; Annette Oxenius

  PLoS Pathogens, 01 Apr. 2018, Peer-reviewed

  
• Glucocorticoids Drive Diurnal Oscillations in T Cell Distribution and Responses by Inducing Interleukin-7 Receptor and CXCR4.

  Akihiro Shimba; Guangwei Cui; Shizue Tani-Ichi; Makoto Ogawa; Shinya Abe; Fumie Okazaki; Satsuki Kitano; Hitoshi Miyachi; Hisakata Yamada; Takahiro Hara; Yasunobu Yoshikai; Takashi Nagasawa; Günther Schütz; Koichi Ikuta

  Immunity, 20 Feb. 2018, Peer-reviewed

  
• グルココルチコイドと免疫概日リズムが制御する生体防御機構

  榛葉旭恒; 生田宏一

  医学のあゆみ, 2018, Invited

  
• グルココルチコイドによる免疫機能の日内変動の制御

  生田宏一; 榛葉旭恒

  アンチ・エイジング医学, 2018, Invited

  
• High fat diet exacerbates murine psoriatic dermatitis by increasing the number of IL-17-producing gamma delta T cells

  Satoshi Nakamizo; Tetsuya Honda; Akimasa Adachi; Takahiro Nagatake; Jun Kunisawa; Akihiko Kitoh; Atsushi Otsuka; Teruki Dainichi; Takashi Nomura; Florent Ginhoux; Koichi Ikuta; Gyohei Egawa; Kenji Kabashima

  SCIENTIFIC REPORTS, Oct. 2017, Peer-reviewed

  
• Hematopoietic Stem Cell Niches Produce Lineage-Instructive Signals to Control Multipotent Progenitor Differentiation

  Ana Cordeiro Gomes; Takahiro Hara; Vivian Y. Lim; Dietmar Herndler-Brandstetter; Erin Nevius; Tatsuki Sugiyama; Shizue Tani-ichi; Susan Schlenner; Ellen Richie; Hans-Reimer Rodewald; Richard A. Flavell; Takashi Nagasawa; Koichi Ikuta; Joao Pedro Pereira

  IMMUNITY, Dec. 2016, Peer-reviewed

  
• Fibroblastic reticular cells regulate intestinal inflammation via IL-15-mediated control of group 1 ILCs

  Cristina Gil-Cruz; Christian Perez-Shibayama; Lucas Onder; Qian Chai; Jovana Cupovic; Hung -Wei Cheng; Mario Novkovic; Philipp A. Lang; Markus B. Geuking; Kathy D. McCoy; Shinya Abe; Guangwei Cui; Koichi Ikuta; Elke Scandella; Burkhard Ludewig

  NATURE IMMUNOLOGY, Dec. 2016, Peer-reviewed

  
• Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency

  Asuka Terashima; Kazuo Okamoto; Tomoki Nakashima; Shizuo Akira; Koichi Ikuta; Hiroshi Takayanagi

  IMMUNITY, Jun. 2016, Peer-reviewed

  
• Thy1(+)IL-7(+) lymphatic endothelial cells in iBALT provide a survival niche for memory T-helper cells in allergic airway inflammation

  Kenta Shinoda; Kiyoshi Hirahara; Tomohisa Iinuma; Tomomi Ichikawa; Akane S. Suzuki; Kaoru Sugaya; Damon J. Tumes; Heizaburo Yamamoto; Takahiro Hara; Shizue Tani-ichie; Koichi Ikuta; Yoshitaka Okamoto; Toshinori Nakayama

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2016, Peer-reviewed

  
• Control of IL-7 receptor expression by an enhancer

  生田宏一; 阿部昌史; 谷一靖江

  医学のあゆみ, 2016, Peer-reviewed

  
• gamma delta T Cells Shape Preimmune Peripheral B Cell Populations

  Yafei Huang; Andrew Getahun; Ryan A. Heiser; Thiago O. Detanico; Katja Aviszus; Greg A. Kirchenbaum; Tamara L. Casper; Chunjian Huang; M. Kemal Aydintug; Simon R. Carding; Koichi Ikuta; Hua Huang; Lawrence J. Wysocki; John C. Cambier; Rebecca L. O'Brien; Willi K. Born

  JOURNAL OF IMMUNOLOGY, Jan. 2016, Peer-reviewed

  
• Ectopic Aire Expression in the Thymic Cortex Reveals Inherent Properties of Aire as a Tolerogenic Factor within the Medulla

  Hitoshi Nishijima; Satsuki Kitano; Hitoshi Miyachi; Junko Morimoto; Hiroshi Kawano; Fumiko Hirota; Ryoko Morita; Yasuhiro Mouri; Kiyoshi Masuda; Issei Imoto; Koichi Ikuta; Mitsuru Matsumoto

  JOURNAL OF IMMUNOLOGY, Nov. 2015, Peer-reviewed

  
• Hair follicle–derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma

  Takeya Adachi; Tetsuro Kobayashi; Eiji Sugihara; Taketo Yamada; Koichi Ikuta; Stefania Pittaluga; Hideyuki Saya; Masayuki Amagai; Keisuke Nagao

  Nature Medicine, Oct. 2015, Peer-reviewed

  
• An Enhancer of the IL-7 Receptor alpha-Chain Locus Controls IL-7 Receptor Expression and Maintenance of Peripheral T Cells

  Akifumi Abe; Shizue Tani-ichi; Soichiro Shitara; Guangwei Cui; Hisataka Yamada; Hitoshi Miyachi; Satsuki Kitano; Takahiro Hara; Ryo Abe; Yasunobu Yoshikai; Koichi Ikuta

  JOURNAL OF IMMUNOLOGY, Oct. 2015, Peer-reviewed

  
• STAT5 Orchestrates Local Epigenetic Changes for Chromatin Accessibility and Rearrangements by Direct Binding to the TCR gamma Locus

  Keisuke Wagatsuma; Shizue Tani-ichi; Bingfei Liang; Soichiro Shitara; Ko Ishihara; Manabu Abe; Hitoshi Miyachi; Satsuki Kitano; Takahiro Hara; Masanobu Nanno; Hiromichi Ishikawa; Kenji Sakimura; Mitsuyoshi Nakao; Hiroshi Kimura; Koichi Ikuta

  JOURNAL OF IMMUNOLOGY, Aug. 2015, Peer-reviewed

  
• Memory CD8(+) T cells colocalize with IL-7(+) stromal cells in bone marrow and rest in terms of proliferation and transcription

  Oezen Sercan Alp; Sibel Durlanik; Daniel Schulz; Mairi McGrath; Joachim R. Gruen; Marcus Bardua; Koichi Ikuta; Evridiki Sgouroudis; Rene Riedel; Sandra Zehentmeier; Anja E. Hauser; Motokazu Tsuneto; Fritz Melchers; Koji Tokoyoda; Hyun-Dong Chang; Andreas Thiel; Andreas Radbruch

  EUROPEAN JOURNAL OF IMMUNOLOGY, Apr. 2015, Peer-reviewed

  
• 生体内リンパ器官におけるサイトカインニッチの解明

  生田宏一; 崔広為; 原崇裕

  感染・炎症・免疫, 2015, Invited

  
• gamma delta T cells affect IL-4 production and B-cell tolerance

  Yafei Huang; Ryan A. Heiser; Thiago O. Detanico; Andrew Getahun; Greg A. Kirchenbaum; Tamara L. Casper; M. Kemal Aydintug; Simon R. Carding; Koichi Ikuta; Hua Huang; John C. Cambier; Lawrence J. Wysocki; Rebecca L. O'Brien; Willi K. Born

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 2015, Peer-reviewed

  
• A Genome-Wide Analysis Identifies a Notch-RBP-J kappa-IL-7R alpha Axis That Controls IL-17-Producing gamma delta T Cell Homeostasis in Mice

  Masataka Nakamura; Kensuke Shibata; Shinya Hatano; Tetsuya Sato; Yasuyuki Ohkawa; Hisakata Yamada; Koichi Ikuta; Yasunobu Yoshikai

  JOURNAL OF IMMUNOLOGY, Jan. 2015, Peer-reviewed

  
• Characterization of the IL-15 niche in primary and secondary lymphoid organs in vivo.

  Cui G; Hara T; Simmons S; Wagatsuma K; Abe A; Miyachi H; Kitano S; Ishii M; Tani-ichi S; Ikuta K

  Proc Natl Acad Sci USA, Feb. 2014, Peer-reviewed

  
• Characterization of the IL-15 niche in primary and secondary lymphoid organs in vivo

  Guangwei Cui; Takahiro Hara; Szandor Simmons; Keisuke Wagatsuma; Akifumi Abe; Hitoshi Miyachi; Satsuki Kitano; Masaru Ishii; Shizue Tani-ichi; Koichi Ikuta

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 2014, Peer-reviewed

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• Environments of B cell development

  Motokazu Tsuneto; Ekaterina Kajikhina; Katharina Seiler; Andreas Reimer; Julia Tornack; Corinne Bouquet; Szandor Simmons; Marko Knoll; Ingrid Wolf; Koji Tokoyoda; Anja Hauser; Takahiro Hara; Shizue Tani-ichi; Koichi Ikuta; Joachim R. Gruen; Andreas Gruetzkau; Niklas Engels; Juergen Wienands; Yuki Yanagisawa; Kazuo Ohnishi; Fritz Melchers

  IMMUNOLOGY LETTERS, Jan. 2014, Peer-reviewed

  
• Reprint of: Environments of B cell development

  Motokazu Tsuneto; Ekaterina Kajikhina; Katharina Seiler; Andreas Reimer; Julia Tornack; Corinne Bouquet; Szandor Simmons; Marko Knoll; Ingrid Wolf; Koji Tokoyoda; Anja Hauser; Takahiro Hara; Shizue Tani-ichi; Koichi Ikuta; Joachim R. Grün; Andreas Grützkau; Niklas Engels; Jürgen Wienands; Yuki Yanagisawa; Kazuo Ohnishi; Fritz Melchers

  Immunology Letters, 2014, Peer-reviewed

  
• 後期T細胞分化におけるIL-7Rの機能

  谷一靖江; 生田宏一

  医学のあゆみ, 2014, Invited

  
• Transcriptional regulation and function of IL-7 receptor in T cells

  谷一靖江; 原崇裕; 生田宏一

  臨床免疫・アレルギー科, 2014, Invited

  
• IL-15産生細胞の可視化—免疫系の微小環境の解明に期待

  生田宏一; 崔広為

  医学のあゆみ, 2014, Invited

  
• 肝細胞が産生するIL-7の機能

  生田宏一

  医学のあゆみ, 2014, Invited

  
• B-Cell Progenitors and Precursors Change Their Microenvironment in Fetal Liver During Early Development

  Motokazu Tsuneto; Koji Tokoyoda; Ekaterina Kajikhina; Anja E. Hauser; Takahiro Hara; Shizue Tani-ichi; Koichi Ikuta; Fritz Melchers

  STEM CELLS, Dec. 2013, Peer-reviewed

  
• Signal transducer and activator of transcription 3 (Stat3) contributes to T-cell homeostasis by regulating pro-survival Bcl-2 family genes

  Jin-Ku Lee; Cheolhee Won; Eun Hee Yi; Seung-Hyeok Seok; Myoung-Hwan Kim; Sang-Jeong Kim; Myung-Hee Chung; Hyun Gyu Lee; Koichi Ikuta; Sang-Kyu Ye

  IMMUNOLOGY, Nov. 2013, Peer-reviewed

  
• CD49b-dependent establishment of T helper cell memory

  Asami Hanazawa; Koji Hayashizaki; Kenta Shinoda; Hideo Yagita; Ko Okumura; Max Loehning; Takahiro Hara; Shizue Tani-ichi; Koichi Ikuta; Beate Eckes; Andreas Radbruch; Koji Tokoyoda; Toshinori Nakayama

  IMMUNOLOGY AND CELL BIOLOGY, Sep. 2013, Peer-reviewed

  
• Lymphocyte-stromal cell interaction induces IL-7 expression by interferon regulatory factors

  Miho Sekai; Shizue Tani-ichi; Mitsutoshi Yoneyama; Takashi Fujita; Tatsuo Kina; Koichi Ikuta

  Molecular Immunology, Jul. 2013, Peer-reviewed

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• IL-7 Produced by Thymic Epithelial Cells Plays a Major Role in the Development of Thymocytes and TCR gamma delta(+) Intraepithelial Lymphocytes

  Soichiro Shitara; Takahiro Hara; Bingfei Liang; Keisuke Wagatsuma; Saulius Zuklys; Georg A. Hollaender; Hiroshi Nakase; Tsutomu Chiba; Shizue Tani-ichi; Koichi Ikuta

  JOURNAL OF IMMUNOLOGY, Jun. 2013, Peer-reviewed

  
• 肝臓IL-7の新たな機能

  生田宏一; 原崇裕; 谷一靖江

  感染・炎症・免疫, 2013, Invited

  
• IL-7産生細胞のリンパ組織内分布

  原崇裕; 生田宏一

  医学のあゆみ, 2013, Invited

  
• Interleukin-7 receptor controls development and maturation of late stages of thymocyte subpopulations

  Shizue Tani-ichi; Akihiro Shimba; Keisuke Wagatsuma; Hitoshi Miyachi; Satsuki Kitano; Kumiko Imai; Takahiro Hara; Koichi Ikuta

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 2013, Peer-reviewed

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• Role of Hepatocyte-Derived IL-7 in Maintenance of Intrahepatic NKT Cells and T Cells and Development of B Cells in Fetal Liver

  Bingfei Liang; Takahiro Hara; Keisuke Wagatsuma; Jia Zhang; Kazushige Maki; Hitoshi Miyachi; Satsuki Kitano; Chihiro Yabe-Nishimura; Shizue Tani-ichi; Koichi Ikuta

  JOURNAL OF IMMUNOLOGY, Nov. 2012, Peer-reviewed

  
• Identification of IL-7-Producing Cells in Primary and Secondary Lymphoid Organs Using IL-7-GFP Knock-In Mice

  Takahiro Hara; Soichiro Shitara; Kumiko Imai; Hitoshi Miyachi; Satsuki Kitano; Hisayuki Yao; Shizue Tani-ichi; Koichi Ikuta

  JOURNAL OF IMMUNOLOGY, Aug. 2012, Peer-reviewed

  
• Regulation of αβ TCR and γδ TCR expression in thymus

  谷一 靖江; 生田 宏一

  Clinical immunology & allergology, Sep. 2011, Peer-reviewed

  
• Cytokines produced by thymic epithelial cells and control of T cell development

  生田 宏一; 原 崇裕; 谷一 靖江

  Clinical immunology & allergology, Sep. 2011, Peer-reviewed

  
• The pre-TCR signal induces transcriptional silencing of the TCR gamma locus by reducing the recruitment of STAT5 and Runx to transcriptional enhancers

  Shizue Tani-ichi; Masanobu Satake; Koichi Ikuta

  INTERNATIONAL IMMUNOLOGY, Sep. 2011, Peer-reviewed

  
• Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy (vol 208, pg 491, 2011)

  Yuting Ma; Laetitia Aymeric; Clara Locher; Stephen R. Mattarollo; Nicolas F. Delahaye; Pablo Pereira; Laurent Boucontet; Lionel Apetoh; Francois Ghiringhelli; Noelia Casares; Juan Jose Lasarte; Goro Matsuzaki; Koichi Ikuta; Bernard Ryffel; Kamel Benlagha; Antoine Tesniere; Nicolas Ibrahim; Julie Dechanet-Merville; Nathalie Chaput; Mark J. Smyth; Guido Kroemer; Laurence Zitvogel

  JOURNAL OF EXPERIMENTAL MEDICINE, Apr. 2011, Peer-reviewed

  
• Contribution of IL-17-producing gamma delta T cells to the efficacy of anticancer chemotherapy

  Yuting Ma; Laetitia Aymeric; Clara Locher; Stephen R. Mattarollo; Nicolas F. Delahaye; Pablo Pereira; Laurent Boucontet; Lionel Apetoh; Francois Ghiringhelli; Noelia Casares; Juan Jose Lasarte; Goro Matsuzaki; Koichi Ikuta; Bernard Ryffel; Kamel Benlagha; Antoine Tesniere; Nicolas Ibrahim; Julie Dechanet-Merville; Nathalie Chaput; Mark J. Smyth; Guido Kroemer; Laurence Zitvogel

  JOURNAL OF EXPERIMENTAL MEDICINE, Mar. 2011, Peer-reviewed

  
• Upregulated IL-7 Receptor alpha Expression on Colitogenic Memory CD4(+) T Cells May Participate in the Development and Persistence of Chronic Colitis

  Tamako Shinohara; Yasuhiro Nemoto; Takanori Kanai; Kaori Kameyama; Ryuichi Okamoto; Kiichiro Tsuchiya; Tetsuya Nakamura; Teruji Totsuka; Koichi Ikuta; Mamoru Watanabe

  JOURNAL OF IMMUNOLOGY, Feb. 2011, Peer-reviewed

  
• エピジェネティクスと免疫疾患

  生田宏一

  MEDCHEM NEWS 、第21 巻、第4 号、pp24- 26 、2011, 2011, Peer-reviewed

  
• Accessibility control of TCR V-gamma region by STAT5

  Shizue Tani-ichi; Hai-Chon Lee; Sang-Kyu Ye; Koichi Ikuta

  INTERNATIONAL IMMUNOLOGY, Aug. 2010, Peer-reviewed

  
• Essential Role of IL-17A in the Formation of a Mycobacterial Infection-Induced Granuloma in the Lung

  Yuko Okamoto Yoshida; Masayuki Umemura; Ayano Yahagi; Rebecca L. O'Brien; Koichi Ikuta; Kenji Kishihara; Hiromitsu Hara; Susumu Nakae; Yoichiro Iwakura; Goro Matsuzaki

  JOURNAL OF IMMUNOLOGY, Apr. 2010, Peer-reviewed

  
• クロマチン構造変換による免疫系の多偸腫獲得機構

  生田宏一

  神戸膠原病研究会, 神戸, 10 月22 日,2010., 2010, Peer-reviewed

  
• Dual role for Id2 in chemical carcinogen-induced skin tumorigenesis

  Atsushi Tokuriki; Tomonori Iyoda; Kayo Inaba; Koichi Ikuta; Shinji Fujimoto; Masanobu Kumakiri; Yoshifumi Yokota

  CARCINOGENESIS, Sep. 2009, Peer-reviewed

  
• Activation of the mouse TCR gamma enhancers by STAT5

  Shizue Tani-ichi; Masanobu Satake; Koichi Ikuta

  INTERNATIONAL IMMUNOLOGY, Sep. 2009, Peer-reviewed

  
• Cutting edge: Inhibition of NF-kappa B-mediated TSLP expression by retinoid X receptor

  Hai-Chon Lee; Mark B. Headley; Masanori Iseki; Koichi Ikuta; Steven F. Ziegler

  JOURNAL OF IMMUNOLOGY, Oct. 2008, Peer-reviewed

  
• IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver.

  Satoru Hamada; Masayuki Umemura; Takeru Shiono; Kensho Tanaka; Ayano Yahagi; M Dilara Begum; Kiyotetsu Oshiro; Yuko Okamoto; Hisami Watanabe; Kazuyoshi Kawakami; Christina Roark; Willi K Born; Rebecca O'Brien; Koichi Ikuta; Hiromichi Ishikawa; Susumu Nakae; Yoichiro Iwakura; Takao Ohta; Goro Matsuzaki

  Journal of immunology (Baltimore, Md. : 1950), 01 Sep. 2008, Peer-reviewed

  
• MEK1/2 induces STAT5-mediated germline transcription of the TCR gamma locus in response to IL-7R signaling

  Kazushige Maki; Koichi Ikuta

  JOURNAL OF IMMUNOLOGY, Jul. 2008, Peer-reviewed

  
• Physical and functional interactions between STAT5 and Runx transcription factors

  Shinya Ogawa; Masanobu Satake; Koichi Ikuta

  JOURNAL OF BIOCHEMISTRY, May 2008, Peer-reviewed

  
• Transcriptional activation of mouse TCR J gamma 4 germline promoter by STAT5

  Naomi Masui; Shizue Tani-ichi; Kazushige Maki; Koichi Ikuta

  MOLECULAR IMMUNOLOGY, Feb. 2008, Peer-reviewed

  
• A reporter assay for Stat5-dependent promoters without cytokine stimulation

  Tsuguto Toda; Hiroyuki Wada; Shinya Ogawa; Shizue Tani-ichi; Koichi Ikuta

  ANALYTICAL BIOCHEMISTRY, Jan. 2008, Peer-reviewed

  
• Induction of the IL-7 receptor alpha chain in mouse peripheral B cells by glucocorticoids

  Hirofumi Shibata; Shizue Tani-ichi; Hai-Chon Lee; Kazushige Maki; Koichi Ikuta

  IMMUNOLOGY LETTERS, Jul. 2007, Peer-reviewed

  
• Accumulation of gamma/delta T cells in the lungs and their roles in neutrophil-mediated host defense against pneumococcal infection

  Chikara Nakasone; Natsuo Yamamoto; Masashi Nakamatsu; Takeshi Kinjo; Kazuya Miyagi; Kaori Uezu; Kiwamu Nakamura; Futoshi Higa; Hiromichi Ishikawa; Rebecca L. O'Brien; Koichi Ikuta; Mitsuo Kaku; Jiro Fujita; Kazuyoshi Kawakami

  MICROBES AND INFECTION, Mar. 2007, Peer-reviewed

  
• Recombination control of the lymphocyte antigen receptor genes by chromatin structural changes

  生田宏一; 谷一靖江

  蛋白質 核酸 酵素, 10 Nov. 2006, Peer-reviewed

  
• Regulatory role of gamma delta T cells in the recruitment of CD4(+) and CD8(+) T cells to lung and subsequent pulmonary fibrosis

  Philip L. Simonian; Christina L. Roark; Fernando Diaz del Valle; Brent E. Palmer; Ivor S. Douglas; Koichi Ikuta; Willi K. Born; Rebecca L. O'Brien; Andrew P. Fontenot

  JOURNAL OF IMMUNOLOGY, Oct. 2006, Peer-reviewed

  
• The 20th IUBMB International Congress in Kyoto

  K Ikuta; R Kageyama; T Honjo

  IUBMB LIFE, May 2006, Peer-reviewed

  
• Transcriptional regulation of the mouse IL-7 receptor a promoter by glucocorticoid receptor

  HC Lee; H Shibata; S Ogawa; K Maki; K Ikuta

  JOURNAL OF IMMUNOLOGY, Jun. 2005, Peer-reviewed

  
• Transcriptional regulation of the mouse interleukin-2 receptor beta chain gene by Ets and Egr-1

  SK Ye; TJ Kim; SS Won; TJ Yoon; TK Park; YC Yoo; YN Kim; HC Lee; K Ikuta; MH Chung; KH Lee

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2005, Peer-reviewed

  
• インターロイキン７レセプターによるリンパ球抗原受容体遺伝子の組換えの制 御機構

  生田宏一

  神戸大学医学研究科大学院講義、神戸、6 月14 日、2005., 2005, Peer-reviewed

  
• CD8 T 細胞の分化におけるSTAT5 の機能

  小川伸哉; 真木一茂; 生田宏一

  免疫コロキ ウム、有馬、2 月21 日、2005., 2005, Peer-reviewed

  
• Generation of a transgenic animal model of hyperthyroid Graves' disease

  M Kim-Saijo; T Akamizu; K Ikuta; Y Iida; K Ohmori; K Matsubara; Y Matsuda; M Suzuki; F Matsuda; K Nakao

  EUROPEAN JOURNAL OF IMMUNOLOGY, Sep. 2003, Peer-reviewed

  
• Elimination of local macrophages in intestine prevents chronic colitis in interleukin-10-deficient mice

  N Watanabe; K Ikuta; K Okazaki; H Nakase; Y Tabata; M Matsuura; H Tamaki; C Kawanami; T Honjo; T Chiba

  DIGESTIVE DISEASES AND SCIENCES, Feb. 2003, Peer-reviewed

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• Activation and differentiation of autoreactive B-1 cells by interleukin 10 induce autoimmune hemolytic anemia in Fas-deficient antierythrocyte immunoglobulin transgenic mice

  N Watanabe; K Ikuta; S Nisitani; T Chiba; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, Jul. 2002, Peer-reviewed

  
• Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision

  H Han; K Tanigaki; N Yamamoto; K Kuroda; M Yoshimoto; T Nakahata; K Ikuta; T Honjo

  INTERNATIONAL IMMUNOLOGY, Jun. 2002, Peer-reviewed

  
• MHC class I-dependent V gamma 4(+) pulmonary T cells regulate alpha beta T cell-independent airway responsiveness

  M Lahn; A Kanehiro; K Takeda; J Terry; YS Hahn; MK Aydintug; A Konowal; K Ikuta; RL O'Brien; EW Gelfand; WK Born

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jun. 2002, Peer-reviewed

  
• Seeding of dendritic epidermal T cells in the neonatal skin is reduced in 129 strain of mice

  HC Lee; K Tomiyama; SK Ye; K Kawai; K Ikuta

  IMMUNOLOGY LETTERS, May 2002, Peer-reviewed

  
• Accessibility control of the TCR gamma locus by the IL-7 receptor

  K. Ikuta; S.K. Ye; H.C. Lee

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2002, Peer-reviewed

  
• The IL-7 receptor controls the accessibility of the TCR gamma locus by Stat5 and histone acetylation

  SK Ye; Y Agata; HC Lee; H Kurooka; T Kitamura; A Shimizu; T Honjo; K Ikuta

  IMMUNITY, Nov. 2001, Peer-reviewed

  
• In situ class switching and differentiation to IgA-producing cells in the gut lamina propria

  S Fagarasan; K Kinoshita; M Muramatsu; K Ikuta; T Honjo

  NATURE, Oct. 2001, Peer-reviewed

  
• Differential roles of cytokine receptors in the development of epidermal gamma delta T cells

  SK Ye; K Maki; HC Lee; A Ito; K Kawai; H Suzuki; TW Mak; YH Chien; T Honjo; K Ikuta

  JOURNAL OF IMMUNOLOGY, Aug. 2001, Peer-reviewed

  
• Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis

  Y Ohba; K Ikuta; A Ogura; J Matsuda; N Mochizuki; K Nagashima; K Kurokawa; BJ Mayer; K Maki; J Miyazaki; M Matsuda

  EMBO JOURNAL, Jul. 2001, Peer-reviewed

  
• Induction of germline transcription in the human TCRγ locus by STAT51

  H. C. Lee; S. K. Ye; T. Honjo; K. Ikuta

  Journal of Immunology, 01 Jul. 2001, Peer-reviewed

  
• Histone acetylation determines the developmentally regulated accessibility for T cell receptor gamma gene recombination

  Y Agata; T Katakai; SK Ye; M Sugai; H Gonda; T Honjo; K Ikuta; A Shimizu

  JOURNAL OF EXPERIMENTAL MEDICINE, Apr. 2001, Peer-reviewed

  
• Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis

  K Honda; H Nakano; H Yoshida; S Nishikawa; P Rennert; K Ikuta; M Tamechika; K Yamaguchi; T Fukumoto; T Chiba; SI Nishikawa

  JOURNAL OF EXPERIMENTAL MEDICINE, Mar. 2001, Peer-reviewed

  
• Role of the IL-7 receptor in gamma-delta T cell development

  K Ikuta; HC Lee; SK Ye

  GAMMA-DELTA T CELLS, 2001, Peer-reviewed

  
• Migration and differentiation of autoreactive B-1 cells induced by activated gamma/delta T cells in antierythrocyte immunoglobulin transgenic mice

  N Watanabe; K Ikuta; S Fagarasan; S Yazumi; T Chiba; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, Dec. 2000, Peer-reviewed

  
• Depletion of a gamma delta T cell subset can increase host resistance to a bacterial infection

  RL O'Brien; Yin, X; SA Huber; K Ikuta; WK Born

  JOURNAL OF IMMUNOLOGY, Dec. 2000, Peer-reviewed

  
• Increased frequency of surface IgA-positive plasma cells in the intestinal lamina propria and decreased IgA excretion in hyper IgA, (HIGA) mice, a murine model of IgA nephropathy with hyperserum IgA

  T Kamata; F Nogaki; S Fagarasan; T Sakiyama; N Kobayashi; S Miyawaki; K Ikuta; E Muso; H Yoshida; S Sasayama; T Honjo

  JOURNAL OF IMMUNOLOGY, Aug. 2000, Peer-reviewed

  
• Alymphoplasia (aly)-type nuclear factor kappa B-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system

  S Fagarasan; R Shinkura; T Kamata; F Nogaki; K Ikuta; K Tashiro; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, May 2000, Peer-reviewed

  
• The monoclonal antibody TER-119 recognizes a molecule associated with glycophorin A and specifically marks the late stages of murine erythroid lineage

  T Kina; K Ikuta; E Takayama; K Wada; AS Majumdar; IL Weissman; Y Katsura

  BRITISH JOURNAL OF HAEMATOLOGY, May 2000, Peer-reviewed

  
• Mechanism of B1 cell differentiation and migration in GALT

  S Fagarasan; R Shinkura; T Kamata; F Nogaki; K Ikuta; T Honjo

  B 1 LYMPHOCYTES IN B CELL NEOPLASIA, 2000, Peer-reviewed

  
• STAT5 as a molecular regulator of proliferation, differentiation and apoptosis in hematopoietic cells

  T Nosaka; T Kawashima; K Misawa; K Ikuta; ALF Mui; T Kitamura

  EMBO JOURNAL, Sep. 1999, Peer-reviewed

  
• Induction of germline transcription in the TCR gamma locus by Stat5: Implications for accessibility control by the IL-7 receptor

  SK Ye; K Maki; T Kitamura; S Sunaga; K Akashi; J Domen; IL Weissman; T Honjo; K Ikuta

  IMMUNITY, Aug. 1999, Peer-reviewed

  
• Expression levels of B cell surface immunoglobulin regulate efficiency of allelic exclusion and size of autoreactive B-1 cell compartment

  N Watanabe; S Nisitani; K Ikuta; M Suzuki; T Chiba; T Honjo

  JOURNAL OF EXPERIMENTAL MEDICINE, Aug. 1999, Peer-reviewed

  
• Requirement of IL-5 for induction of autoimmune hemolytic anemia in anti-red blood cell autoantibody transgenic mice

  T Sakiyama; K Ikuta; S Nisitani; K Takatsu; T Honjo

  INTERNATIONAL IMMUNOLOGY, Jun. 1999, Peer-reviewed

  
• IL-7 receptor alpha(+) CD3(-) cells in the embryonic intestine induces the organizing center of Peyer's patches

  H Yoshida; K Honda; R Shinkura; S Adachi; S Nishikawa; K Maki; K Ikuta; S Nishikawa

  INTERNATIONAL IMMUNOLOGY, May 1999, Peer-reviewed

  
• Alymphoplasia is caused by a point mutation in the mouse gene encoding nf-κb-inducing kinase

  Reiko Shinkura; Kazuhiro Kitada; Fumihiko Matsuda; Kei Tashiro; Koichi Ikuta; Misao Suzuki; Katsumi Kogishi; Tadao Serikawa; Tasuku Honjo

  Nature Genetics, May 1999, Peer-reviewed

  
• Antigen-driven clonal accumulation of peritoneal gamma delta T cells in vivo

  Y Kodaira; K Ikuta; S Tanaka; K Yokomuro

  IMMUNOLOGICAL INVESTIGATIONS, 1999, Peer-reviewed

  
• 免疫グロブリン遺伝子の組換え制御におけるプレB細胞レセプターとIL-7レセプターの役割

  真木一茂; 永田喜三郎; 北村ふじ子; 生田宏一; 烏山一

  日本免疫学会総会・学術集会記録, 1999

  
• Impaired anaphylactic responses with intact sensitivity to endotoxin in mice lacking a platelet-activating factor receptor

  S Ishii; T Kuwaki; T Nagase; K Maki; F Tashiro; S Sunaga; WH Cao; K Kume; Y Fukuchi; K Ikuta; J Miyazaki; M Kumada; T Shimizu

  JOURNAL OF EXPERIMENTAL MEDICINE, Jun. 1998, Peer-reviewed

  
• Essential role of IL-7 receptor alpha in the formation of Peyer's patch anlage

  S Adachi; H Yoshida; K Honda; K Maki; K Saijo; K Ikuta; T Saito; S Nishikawa

  INTERNATIONAL IMMUNOLOGY, Jan. 1998, Peer-reviewed

  
• Role of cytosolic phospholipase A(2) in allergic response and parturition

  N Uozumi; K Kume; T Nagase; N Nakatani; S Ishii; F Tashiro; Y Komagata; K Maki; K Ikuta; Y Ouchi; J Miyazaki; T Shimizu

  NATURE, Dec. 1997, Peer-reviewed

  
• Increased B-lymphopoiesis by interleukin 7 induces bone loss in mice with intact ovarian function: Similarity to estrogen deficiency

  C Miyaura; Y Onoe; M Inada; K Maki; K Ikuta; M Ito; T Suda

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 1997, Peer-reviewed

  
• Murine interleukin 4 transgenic heart allograft survival prolonged with down-regulation of the TH1 cytokine mRNA in grafts

  T Takeuchi; T Ueki; S Sunaga; K Ikuta; Y Sasaki; BX Li; N Moriyama; J Miyazaki; K Kawabe

  TRANSPLANTATION, Jul. 1997, Peer-reviewed

  
• Developmentally ordered V-J recombination in mouse T cell receptor gamma locus is not perturbed by targeted deletion of the V gamma 4 gene

  S Sunaga; K Maki; Y Komagata; J Miyazaki; K Ikuta

  JOURNAL OF IMMUNOLOGY, May 1997, Peer-reviewed

  
• Efficient removal of loxP-flanked DNA sequences in a gene-targeted locus by transient expression of cre recombinase in fertilized eggs

  Shinji Sunaga; Kazushige Maki; Yoshinori Komagata; Koichi Ikuta; Jun-Ichi Miyazaki

  Molecular Reproduction and Development, Feb. 1997, Peer-reviewed

  
• Myeloid differentiation is impaired in transgenic mice with targeted expression of a dominant negative form of retinoid X receptor beta

  S Sunaga; K Maki; E Lagasse; JCG Blanco; K Ozato; J Miyazaki; K Ikuta

  BRITISH JOURNAL OF HAEMATOLOGY, Jan. 1997, Peer-reviewed

  
• Heterogeneity of gamma delta T cells in the mouse liver

  Y Kodaira; K Ikuta; S Tanaka; JI Miyazaki; K Yokomuro

  CELLS OF THE HEPATIC SINUSOID, VOL 6, 1997, Peer-reviewed

  
• Bronchial hyperreactivity, increased endotoxin lethality and melanocytic tumorigenesis in transgenic mice overexpressing platelet-activating factor receptor

  S Ishii; T Nagase; F Tashiro; K Ikuta; S Sato; Waga, I; K Kume; J Miyazaki; T Shimizu

  EMBO JOURNAL, Jan. 1997, Peer-reviewed

  
• The V-J recombination of T cell receptor-gamma genes is blocked in interleukin-7 receptor-deficient mice

  K Maki; S Sunaga; K Ikuta

  JOURNAL OF EXPERIMENTAL MEDICINE, Dec. 1996, Peer-reviewed

  
• Identification of novel lymphoid tissues in murine intestinal mucosa where clusters of c-kit(+) IL-7R(+) Thy1(+) lympho-hemopoietic progenitors develop

  Y Kanamori; K Ishimaru; M Nanno; K Maki; K Ikuta; H Nariuchi; H Ishikawa

  JOURNAL OF EXPERIMENTAL MEDICINE, Oct. 1996, Peer-reviewed

  
• Preferential requirement of CD3 zeta-mediated signals for development of immature rather than mature thymocytes

  T Aoe; Y Okamoto; H Arase; K Ikuta; J Miyazaki; S Ono; M Otuji; H Ohno; S Miyatake; T Saito

  INTERNATIONAL IMMUNOLOGY, Jul. 1996, Peer-reviewed

  
• Interleukin 7 receptor-deficient mice lack gamma delta T cells

  K Maki; S Sunaga; Y Komagata; Y Kodaira; A Mabuchi; H Karasuyama; K Yokomuro; J Miyazaki; K Ikuta

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jul. 1996, Peer-reviewed

  
• Clonal prevalence of T cells infiltrating into the pancreas of prediabetic non-obese diabetic mice

  Y Komagata; K Masuko; F Tashiro; T Kato; K Ikuta; K Nishioka; K Ito; J Miyazaki; K Yamamoto

  INTERNATIONAL IMMUNOLOGY, Jun. 1996, Peer-reviewed

  
• Heterogeneity of N insertion capacity in fetal hematopoietic stem cells

  Y Komagata; IL Weissman; K Ikuta

  INTERNATIONAL IMMUNOLOGY, Jun. 1996, Peer-reviewed

  
• Defective B-l cell development and impaired immunity against Angiostrongylus cantonensis in IL-5R alpha-deficient mice

  T Yoshida; K Ikuta; H Sugaya; K Maki; M Takagi; H Kanazawa; S Sunaga; T Kinashi; K Yoshimura; J Miyazaki; S Takaki; K Takatsu

  IMMUNITY, May 1996, Peer-reviewed

  
• Developmental heterogeneity of V gamma 1.1 T cells in the mouse liver

  Y Kodaira; K Yokomuro; S Tanaka; JI Miyazaki; K Ikuta

  IMMUNOLOGY, Feb. 1996, Peer-reviewed

  
• INHIBITION OF PANCREATIC BETA-CELL GLUCOKINASE BY ANTISENSE RNA EXPRESSION IN TRANSGENIC MICE - MOUSE STRAIN-DEPENDENT ALTERATION OF GLUCOSE-TOLERANCE

  H ISHIHARA; F TASHIRO; K IKUTA; T ASANO; H KATAGIRI; K INUKAI; M KIKUCHI; Y YAZAKI; Y OKA; J MIYAZAKI

  FEBS LETTERS, Sep. 1995, Peer-reviewed

  
• FUNCTIONAL-HETEROGENEITY IS ASSOCIATED WITH THE CELL-CYCLE STATUS OF MURINE HEMATOPOIETIC STEM-CELLS

  WH FLEMING; EJ ALPERN; N UCHIDA; K IKUTA; GJ SPANGRUDE; IL WEISSMAN

  JOURNAL OF CELL BIOLOGY, Aug. 1993, Peer-reviewed

  
• STEEL FACTOR INFLUENCES THE DISTRIBUTION AND ACTIVITY OF MURINE HEMATOPOIETIC STEM-CELLS INVIVO

  WH FLEMING; EJ ALPERN; N UCHIDA; K IKUTA; IL WEISSMAN

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Apr. 1993, Peer-reviewed

  
• T lymphocyte development from fetal hematopoietic stem cells

  K. Ikuta; I.L. Weissman

  Seminars in Developmental Biology, 1993, Peer-reviewed

  
• DEVELOPMENT OF GAMMA-DELTA T-CELL SUBSETS FROM FETAL HEMATOPOIETIC STEM-CELLS

  K IKUTA; T KINA; MACNEIL, I; N UCHIDA; B PEAULT; YH CHIEN; IL WEISSMAN

  ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, May 1992, Peer-reviewed

  
• EVIDENCE THAT HEMATOPOIETIC STEM-CELLS EXPRESS MOUSE C-KIT BUT DO NOT DEPEND ON STEEL FACTOR FOR THEIR GENERATION

  K IKUTA; IL WEISSMAN

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 1992, Peer-reviewed

  
• LYMPHOCYTE DEVELOPMENT FROM STEM-CELLS

  K IKUTA; N UCHIDA; J FRIEDMAN; IL WEISSMAN

  ANNUAL REVIEW OF IMMUNOLOGY, 1992, Peer-reviewed

  
• DEVELOPMENT OF GAMMA-DELTA T-CELL SUBSETS FROM FETAL HEMATOPOIETIC STEM-CELLS

  K IKUTA; T KINA; MACNEIL, I; N UCHIDA; B PEAULT; YH CHIEN; IL WEISSMAN

  CD5 B CELLS IN DEVELOPMENT AND DISEASE, 1992, Peer-reviewed

  
• THE JUNCTIONAL MODIFICATIONS OF A T-CELL RECEPTOR GAMMA-CHAIN ARE DETERMINED AT THE LEVEL OF THYMIC PRECURSORS

  K IKUTA; IL WEISSMAN

  JOURNAL OF EXPERIMENTAL MEDICINE, Nov. 1991, Peer-reviewed

  
• MOUSE HEMATOPOIETIC STEM-CELLS

  GJ SPANGRUDE; L SMITH; N UCHIDA; K IKUTA; S HEIMFELD; J FRIEDMAN; IL WEISSMAN

  BLOOD, Sep. 1991, Peer-reviewed

  
• MOUSE HEMATOPOIETIC STEM-CELLS AND THE INTERACTION OF C-KIT RECEPTOR AND STEEL FACTOR

  K IKUTA; DE INGOLIA; J FRIEDMAN; S HEIMFELD; IL WEISSMAN

  INTERNATIONAL JOURNAL OF CELL CLONING, Sep. 1991, Peer-reviewed

  
• A DEVELOPMENTAL SWITCH IN THYMIC LYMPHOCYTE MATURATION POTENTIAL OCCURS AT THE LEVEL OF HEMATOPOIETIC STEM-CELLS

  K IKUTA; T KINA; MACNEIL, I; N UCHIDA; B PEAULT; YH CHIEN; IL WEISSMAN

  CELL, Sep. 1990, Peer-reviewed

  
• STEPWISE PROGRESSION OF B-CELL MALIGNANCY OCCURRED IN A BONE-MARROW STROMAL CELL-DEPENDENT PRE-B-CELL CLONE

  M OGAWA; K IKUTA; Y KATSURA; S NISHIKAWA

  LEUKEMIA, Apr. 1989, Peer-reviewed

  
• B-CELL ONTOGENY IN MURINE EMBRYO STUDIED BY A CULTURE SYSTEM WITH THE MONOLAYER OF A STROMAL CELL CLONE, ST2 - B-CELL PROGENITOR DEVELOPS 1ST IN THE EMBRYONAL BODY RATHER THAN IN THE YOLK-SAC

  M OGAWA; S NISHIKAWA; K IKUTA; F YAMAMURA; M NAITO; K TAKAHASHI; S NISHIKAWA

  EMBO JOURNAL, May 1988, Peer-reviewed

  
• EVIDENCE FOR THE INTERLEUKIN-2 DEPENDENT EXPANSION OF LEUKEMIC-CELLS IN ADULT T-CELL LEUKEMIA

  M MAEDA; N ARIMA; Y DAITOKU; M KASHIHARA; H OKAMOTO; T UCHIYAMA; K SHIRONO; M MATSUOKA; T HATTORI; K TAKATSUKI; K IKUTA; A SHIMIZU; T HONJO; J YODOI

  BLOOD, Nov. 1987, Peer-reviewed

  
• HUMAN-LYMPHOCYTE FC RECEPTOR FOR IGE - SEQUENCE HOMOLOGY OF ITS CLONED CDNA WITH ANIMAL LECTINS

  K IKUTA; M TAKAMI; CW KIM; T HONJO; T MIYOSHI; Y TAGAYA; T KAWABE; J YODOI

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 1987, Peer-reviewed

  
• EXPRESSION AND REARRANGEMENT OF THE ALPHA-CHAIN, BETA-CHAIN, AND GAMMA-CHAIN GENES OF THE T-CELL RECEPTOR IN CLONED MURINE LARGE ANTIGRANULOCYTES LYMPHOCYTE LINES - NO CORRELATION WITH THE CYTOTOXIC SPECTRUM

  K IKUTA; M HATTORI; K WAKE; S KANO; T HONJO; J YODOI; N MINATO

  JOURNAL OF EXPERIMENTAL MEDICINE, Aug. 1986, Peer-reviewed

  
• A JOINING-DIVERSITY-JOINING COMPLEX GENERATED BY INVERSION MECHANISM AND A VARIABLE-DIVERSITY COMPLEX IN THE BETA-CHAIN GENE OF THE HUMAN T-CELL RECEPTOR

  K IKUTA; T OGURA; A SHIMIZU; T HONJO

  NUCLEIC ACIDS RESEARCH, Jun. 1986, Peer-reviewed

  
• ORIGIN OF HUMAN T-LYMPHOTROPHIC VIRUS-I-POSITIVE T-CELL LINES IN ADULT T-CELL LEUKEMIA - ANALYSIS OF T-CELL RECEPTOR GENE REARRANGEMENT

  M MAEDA; A SHIMIZU; K IKUTA; H OKAMOTO; M KASHIHARA; T UCHIYAMA; T HONJO; J YODOI

  JOURNAL OF EXPERIMENTAL MEDICINE, 1985, Peer-reviewed

  
• RAT LYMPHOID-CELL LINES PRODUCING HUMAN T-CELL LEUKEMIA-VIRUS .2. CONSTITUTIVE EXPRESSION OF RAT INTERLEUKIN-2 RECEPTOR

  J YODOI; M OKADA; Y TAGAYA; K TESHIGAWARA; K FUKUI; N ISHIDA; KI IKUTA; M MAEDA; T HONJO; H OSAWA; T DIAMANTSTEIN; M TATENO; T YOSHIKI

  JOURNAL OF EXPERIMENTAL MEDICINE, 1985, Peer-reviewed

  
• LOW-FREQUENCY OF SOMATIC MUTATION IN BETA-CHAIN VARIABLE REGION GENES OF HUMAN T-CELL RECEPTORS

  K IKUTA; T OGURA; A SHIMIZU; T HONJO

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, Peer-reviewed

  

Misc.

• 肝臓内IL-15産生性微小環境による1型自然リンパ球を介した抗腫瘍免疫の制御

  旭拓真; 榛葉旭恒; 崔広為; 阿部真也; 生田宏一

  日本分子生物学会年会プログラム・要旨集(Web), 2020

  
• Pleiotropic Effects of Glucocorticoids on the Immune System in Circadian Rhythm and Stress

  Akihiro Shimba; Aki Ejima; Koichi Ikuta

  Frontiers in Immunology, 08 Oct. 2021

  
• 〈Basic Science〉γδT細胞による生体制御 γδT細胞の恒常性維持機構

  谷一靖江; 生田宏一

  炎症と免疫, 2022

  
• 転写因子によるTCR Vγ遺伝子の組換え制御機構

  谷一靖江; 縣保年; 生田宏一

  日本免疫学会総会・学術集会記録, 2006

  
• IL-7レセプターとStat5によるT細胞抗原受容体γ鎖遺伝子座の制御

  生田宏一; 谷一靖江

  日本分子生物学会年会講演要旨集, 2005

  
• STAT5によるTCRγ鎖V領域の組換え誘導機構

  谷一靖江; LEE Hai-chon; 生田宏一

  日本免疫学会総会・学術集会記録, 2005

  
• Circulating iNKT cells mediate antiviral and antitumor immunity

  CUI Guangwei; 生田宏一

  医学のあゆみ, 2023

  
• Influence of vitamin A deficiency on the mouse gut microbiota revealed by our newly developed method,“BarBIQ”

  山本れいこ; JIN Jianshi; CUI Guangwei; 竹内直志; 宮内栄治; 北條望; 大野博司; 大野博司; 生田宏一; 城口克之

  腸内細菌学雑誌, 2022

  
• 【免疫系の概日リズム】グルココルチコイドによる免疫応答能の概日制御

  榛葉 旭恒; 生田 宏一

  医学のあゆみ, Apr. 2022

  
• 【γδT細胞による生体制御】γδT細胞の恒常性維持機構

  谷一 靖江; 生田 宏一

  炎症と免疫, Apr. 2022

  
• Tリンパ球の分化と機能におけるIL-7受容体シグナルの役割

  崔 広為; 谷一 靖江; 生田 宏一

  生化学, Dec. 2021, Invited

  Access this misc :

  
• IL-7とγδT細胞の分化

  生田 宏一

  Minophagen Medical Review, Nov. 2006

  
• クロマチン構造変換によるリンパ球抗原受容体遺伝子の組換え制御機構

  生田 宏一

  生化学, Jan. 2004

  
• ヒストン修飾によるリンパ球分化の制御

  生田 宏一

  臨床免疫, Dec. 2003

  
• 【免疫2003】免疫細胞のシグナル伝達 IL-7レセプターによるTCRγ遺伝子座の組換えの制御

  生田 宏一; ぜい 相奎; 李 海天

  Molecular Medicine, Dec. 2002

  
• 【免疫研究の最前線 高次複雑系免疫システムの包括的理解をめざして】リンパ球分化の分子メカニズム IL-7レセプターによるTCRγ遺伝子座のaccessibility調節機構

  生田 宏一; ぜい 相奎; 李 海天

  蛋白質・核酸・酵素, Dec. 2002

  
• ヒストンのアセチル化による抗原レセプター遺伝子組換え制御

  縣 保年; 生田 宏一

  臨床免疫, Dec. 2001

  
• 免疫組織 IL-7レセプターシグナルによるTCRγ遺伝子座の組換え制御

  生田 宏一; ぜい 相奎; 李 海天; 縣 保年

  Annual Review免疫, Dec. 2001

  
• Genetic Disease 先天性免疫不全症の分子遺伝学

  生田 宏一

  遺伝子医学, Nov. 2001

  
• TCR遺伝子再構成におけるgermline転写の役割

  生田 宏一; ぜい 相奎; 李 海天

  臨床免疫, Oct. 2001

  
• 【クロマチン修飾と構造変換】クロマチン修飾とリモデリングによる抗原レセプター遺伝子組換え制御

  縣 保年; 生田 宏一

  実験医学, Oct. 2001

  
• 【抗原レセプター遺伝子の再構成とクラススイッチの制御機構】IL-7レセプターシグナルによるTCRγ遺伝子再構成の制御

  生田 宏一; ぜい 相奎; 李 海天

  実験医学, Mar. 2001

  
• 【DNA修復機構】DNA修復酵素によるリンパ球抗原受容体遺伝子の多様性獲得機構

  生田 宏一; Ye Sang-Kyu; Lee Hai-Chon

  細胞工学, Sep. 2000

  
• 【T細胞の分化をめぐって】TCR遺伝子再構成の誘導機構

  生田 宏一

  臨床免疫, Mar. 2000

  
• 【臨床遺伝子学'99 免疫研究の最前線】リンパ球の発生・分化 IL-7受容体によるTCRγ遺伝子組換えの調節

  生田 宏一

  最新医学, Sep. 1999

  
• 【生体応答学の新展開】免疫応答 液性免疫応答

  生田 宏一

  医学のあゆみ, May 1999

  
• 【胸腺T細胞の分化をめぐって】T細胞レセプター遺伝子の再構成とIL-7シグナル

  生田 宏一

  臨床免疫, Mar. 1999

  
• IL-7とγδT細胞の分化

  生田 宏一

  アレルギー科, Feb. 1999

  
• 【免疫系の再構築とその制御】初期分化機構

  生田 宏一

  血液・免疫・腫瘍, Jan. 1999

  
• 【T細胞レセプター遺伝子の再構成】TCR遺伝子再構成とIL-7レセプターシグナル

  生田 宏一; Kyu Ye Sang; 真木 一茂

  臨床免疫, Sep. 1998

  
• 【遺伝子異常と骨代謝】遺伝子異常の解析法 疾患モデルとしてのトランスジェニック動物

  須永 真司; 生田 宏一

  腎と骨代謝, Jul. 1998

  
• IL-7とT細胞レセプター遺伝子再構成

  生田 宏一

  臨床免疫, May 1998

  
• 【免疫反応の最前線 NK T細胞とγδT細胞】γδT細胞の分化

  生田 宏一; 須永 真司; 真木 一茂

  炎症と免疫, Oct. 1997

  
• サイトカインと免疫調節 IL-7レセプター欠損マウスとγδT細胞の分化

  生田 宏一; 真木 一茂; 須永 真司

  Molecular Medicine, Sep. 1997

  
• IL-7レセプターのノックアウトマウス

  生田 宏一; 真木 一茂; 須永 真司

  免疫Immunology Frontier, Jun. 1997

  
• 肝関連リンパ球 肝に分布するγδT細胞のheterogeneityの解析

  小平 祐造; 生田 宏一; 馬渕 綾子; 田中 茂夫; 横室 公三

  肝類洞壁細胞研究の進歩, Apr. 1997

  
• c-mpl遺伝子と造血幹細胞分化

  須永 真司; 生田 宏一

  最新医学, Nov. 1996

  
• T細胞レセプター遺伝子再構成の年齢による変化

  生田 宏一

  臨床免疫, Nov. 1993

  
• γδ型T細胞の分化

  生田 宏一

  免疫Immunology Frontier, Feb. 1993

  
• 造血幹細胞の個体発生とγδ型細胞の分化

  生田 宏一

  Medical Immunology, Aug. 1992

  
• 胎児期造血幹細胞からのγδ型T細胞の分化

  生田 宏一

  細胞工学, Jul. 1992

  
• リンパ球のホーミング・レセプター

  生田 宏一

  Medical Immunology, Sep. 1990

  
• 造血幹細胞の鈍化 マウス全能性造血幹細胞の単離と動物モデルを用いたヒト造血幹細胞研究の可能性

  並川 玲子; 生田 宏一; 金島 秀人

  実験医学, Oct. 1989

  
• 全能性造血幹細胞の純化

  生田 宏一

  生体防御, Oct. 1989

  
• FcεRの構造と発現調節

  河辺 拓己; 高見 正明; 生田 宏一

  最新医学, Apr. 1987

  
• 免疫応答の多様性を支えるしくみ T細胞抗原受容体の多様性発現機構

  生田 宏一; 本庶 佑

  化学と生物, Jan. 1986

  
• 成人T細胞性白血病(ATL)に由来するT細胞株の起源 T細胞抗原受容体遺伝子を用いたクローン解析

  前田 道之; 清水 章; 生田 宏一

  Medical Immunology, Nov. 1985

  
• P108 血小板活性化因子(PAF)受容体トランスジェニックマウス : PAFの心血管系に対する作用

  中島 敏明; 瀬崎 和典; 山下 武志; 小俣 政男; 石井 聡; 和賀 巌; 清水 孝雄; 田代 文; 生田 宏一; 宮崎 純一

  Japanese circulation journal, 01 Mar. 1995

  
• ヒストンアセチル化によるTCRγ遺伝子V-J組換えの制御機構

  縣 保年; 片貝 智哉; Ye Sang-Kyu; 生田 宏一; 清水 章

  日本免疫学会総会・学術集会記録, Nov. 2000

  
• T細胞の維持と免疫応答におけるIL-7受容体の発現制御と機能

  榛葉旭恒; 生田宏一

  臨床免疫・アレルギー科, 25 Sep. 2020, Invited

  
• グルココルチコイドによる免疫応答の日内変動制御

  榛葉旭恒; 生田宏一

  感染・炎症・免疫, 2019, Invited

  
• グルココルチコイドによる正負の免疫制御

  榛葉旭恒; 生田宏一

  生体の科学, 2019, Invited

  
• 概日リズムが制御する免疫応答の日内変動と炎症疾患

  榛葉旭恒; 生田宏一

  実験医学, 2019, Invited

  
• Osteoblasts mediate immunosuppression during sepsis by regulating lymphopoiesis

  Asuka Terashima; Kazuo Okamoto; Tomoki Nakashima; Koichi Ikuta; Hiroshi Takayanagi

  CYTOKINE, Dec. 2017

  
• Glucocorticoids Drive Circadian Changes in T-Cell Homing and Response via IL-7 Receptor

  Akihiro Shimba; Koichi Ikuta

  JOURNAL OF IMMUNOLOGY, May 2017

  
• Competitive signaling between STAT5 and PI3K of the IL-7R modulates T cell development and homeostasis in vivo

  G. Cui; A. Shimba; S. Tani-ichi; T. Hara; K. Ikuta

  EUROPEAN JOURNAL OF IMMUNOLOGY, Aug. 2016

  
• Role of TCR gamma enhancer 'E gamma 4' for the development and function of gamma delta T cells

  S. Tani-ichi; K. Ikuta

  EUROPEAN JOURNAL OF IMMUNOLOGY, Aug. 2016

  
• Hematopoietic stem cell niches control multipotent progenitor differentiation

  Joao P. Pereira; Vivian Lim; Ana Gomes; Takahiro Hara; Dietmar Herndler-Brandstetter; Richard A. Flavell; Takashi Nagasawa; Koichi Ikuta

  JOURNAL OF IMMUNOLOGY, May 2016

  
• 肝臓IL-7の新たな機能

  生田宏一; 原崇裕; 谷一靖江

  感染 炎症 免疫, 2014

  
• STAT5によるTCRγ遺伝子座の組換え制御機構

  生田宏一; 谷一靖江

  医学のあゆみ, 2011

  
• Role of the IL-7 receptor in γδT-cell development from hematopoietic stem cells.

  Koichi Ikuta; Shizue Tani-ichi

  Hematopoietic Stem Cell Biology, Humana Press Inc., 2009

  
• 自然免疫リンパ球を介した肺炎球菌感染初期防御におけるIFN-γの役割

  八田 益充; 仲松 正司; 仲宗根 力; 仲村 究; 宮里 明子; 藤田 次郎; 賀来 満夫; 川上 和義; 谷口 克; 中山 俊憲; 生田 宏一; O'Brien Rebecca L

  感染症学雑誌, Jan. 2007

  
• クロマチン構造変換によるリンパ球 抗原受容体遺伝子の組換え制御

  生田宏一; 谷一靖江

  蛋白質 核酸 酵素, 2006

  
• 細菌感染症と宿主応答 自然免疫 肺炎球菌感染により活性化されたNKT細胞とγδT細胞におけるIFN-γ産生の解析

  八田益充; 仲松正司; 仲宗根力; 中村究; 宮里明子; 藤田次郎; 中山俊憲; 谷口克; 生田宏一; 賀来満夫; 川上和義

  日本免疫学会総会・学術集会記録, 2006

  
• Elimination of local macrophages in the intestine prevents chronic colitis in interleukin-10 deficient mice

  N Watanabe; K Ikuta; K Okazaki; H Nakase; Y Tabata; M Matsuura; H Tamaki; T Honjo; T Chiba

  GASTROENTEROLOGY, Apr. 2002

  
• ヒストンアセチル化によるV(D)J組換えのaccessibility制御機構

  県保年; YE S‐K; 片貝智哉; 菅井学; 権田裕之; 本庶佑; 生田宏一; 清水章

  日本分子生物学会年会プログラム・講演要旨集, 25 Nov. 2000

  
• Increased resistance to bacterial infection in mice lacking V gamma 1+gamma delta T cells.

  RL O'Brien; EK Pflum; Yin, X; A Konoval; SA Huber; K Ikuta; WK Born

  FASEB JOURNAL, Apr. 2000

  
• Differentiation and migration of B1 cells in GALT

  S Fagarasan; R Shinkura; T Kamata; F Nogaki; K Ikuta; T Honjo

  FASEB JOURNAL, Apr. 2000

  
• Murine IL-4 transgenic heart allograft survival was prolonged with downregulation of TH1 cytokine mRNAs in grafts.

  T Takeuchi; K Ikuta; T Ueki; Y Sasaki; N Moriyama; K Kawabe; J Miyazaki

  JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Sep. 1996

  
• 発生工学によるPAF受容体の機能の解析

  石井 聡; 粂 和彦; 和泉 孝志; 清水 孝雄; 長瀬 隆英; 福地 義之助; 桑木 共之; 熊田 衛; 田代 文; 生田 宏一; 宮崎 純一; 野間 正名

  日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

  
• PCR-SSCP analysis of clonotypes of infiltrating T cells into NOD mouse pancreas.

  田代文; 駒形嘉紀; 増子佳世; 生田宏一; 加藤智啓; 伊藤幸治; 西岡久寿樹; 山本一彦; 宮崎純一

  日本免疫学会総会・学術集会記録, Oct. 1994

  
• PCR-SSCP analysis of clonotypes of T cells infiltrating into NOD mouse pancreas.

  駒形嘉紀; 増子佳世; 生田宏一; 加藤智啓; 伊藤幸治; 西岡久寿樹; 山本一彦; 宮崎純一

  日本免疫学会総会・学術集会記録, Oct. 1993

  

Presentations

• ストレスはグルココルチコイドを介してTh17細胞の分化を促進し腸炎を増悪させる

  榛葉旭恒; 生田宏一

  Kyoto T Cell Conference 第30回学術集会, 09 Oct. 2021

  
• ステロイドホルモンによる免疫機能とアレルギーの制御

  生田宏一; 榛葉旭恒; 江島亜希

  日本アレルギー学会学術集会、JSA-JSI Joint Session, 08 Oct. 2021

  
• 胎児肝臓に由来する1型自然リンパ球の同定

  旭拓真; 阿部真也; 崔広為; 榛葉旭恒; 生田宏一

  Kyoto T Cell Conference 第30回学術集会, 08 Oct. 2021

  
• Circadian control of immunity by glucocorticoid

  Ikuta, K; Shimba, A

  第43回日本分子生物学会年会, 03 Dec. 2020, Invited

  
• 免疫学の視点からコロナ時代を見る

  生田宏一

  東京大学医学部 医学序論連続講座シリーズXX「医の原点」, 01 Oct. 2020, Invited

  
• Thymic IL-15 niche controls anti-tumor immunity by regulating a novel subset of iNKT cells

  Cui, G; Ikuta, K

  第48回日本免疫学会学術集会, 13 Dec. 2019

  
• Role of local IL-7 in maintenance of ILC2s

  Takami, D; Abe, S; Shimba, A; Asahi, T; Zhu, Y; Ejima, A; Tani-ichi, S; Hara, T; Cui, G; Ikuta, K

  第48回日本免疫学会学術集会, 13 Dec. 2019

  
• The cytokine-producing immune microenvironment for innate lymphocytes

  Ikuta, K; Cui, G; Abe, S; Asahi, T; Hara, T

  第48回日本免疫学会学術集会, 13 Dec. 2019, Invited

  
• Control of immunity by glucocorticoids

  Shimba, A; Ikuta, K

  第48回日本免疫学会学術集会, 12 Dec. 2019, Invited

  
• Estrogens suppress T cell production by a TEC-dependent mechanism

  Abe, S; Ejima, A; Shimba, A; Mori, M; Cui, G; Asahi, T; Takami, D; Hara, T; Tani-ichi, S; Ikuta, K

  第48回日本免疫学会学術集会, 11 Dec. 2019

  
• Function of IL-7Ralpha in regulatory T cells

  Tani-ichi, S; Mukohira, H; Hara, T; Ikuta, K

  第48回日本免疫学会学術集会, 11 Dec. 2019

  
• 気管支喘息においてアンドロゲンはTh2細胞分化を抑制することで症状を緩和する

  江島亜希; 岡崎史恵; 榛葉旭恒; 生田宏一

  第42回日本分子生物学会年会, 06 Dec. 2019

  
• グルココルチコイドによるT細胞応答の概日制御

  生田宏一; 榛葉旭恒

  第42回日本分子生物学会年会, 03 Dec. 2019, Invited

  
• マウス喘息モデルにおける性ステロイドホルモンの影響の解析

  江島亜希; 岡崎史恵; 榛葉旭恒; 生田宏一

  第41回日本分子生物学会年会, 30 Nov. 2019

  
• NK細胞の分化を支持するIL-15産生性骨髄微小環境の解明

  阿部真也; 原崇裕; 崔広為; 生田宏一

  Kyoto T Cell Conference 第29回学術集会, 08 Jun. 2019

  
• 制御性T細胞におけるIL-7レセプターの役割

  谷一靖江; 生田宏一

  Kyoto T Cell Conference 第29回学術集会, 07 Jun. 2019

  
• The effects of sex steroid hormones in the mouse model of asthma

  Ejima, A; Okazaki, F; Shimba, A; Ikuta, K

  The 17th International Student Seminar, 06 Mar. 2019

  
• Analysis on IL7- and IL15-producing microenvironment in the lung

  Takami, D; Abe, S; Ikuta, K

  The 17th International Student Seminar, 06 Mar. 2019

  
• Local IL-15 dependency of liver-resident ILC1

  Asahi, T; Shimba, A; Cui, G; Abe, S; Ikuta, K

  The 17th International Student Seminar, 06 Mar. 2019

  
• Intestinal epithelial cell-derived IL-15 supports the homeostasis of intraepithelial lymphocytes

  Zhu, Y; Cui, G; Shimba, A; Abe, S; Hara, T; Tani-ichi, S; Ikuta, K

  第47回日本免疫学会学術集会, 12 Dec. 2018

  
• CXCL12-expressing bone marrow stromal cells express adiponectin and are targeted by Adipoq-Cre transgene

  Mukohira, H; Hara, T; Tani-ichi, S; Ikuta, K

  第47回日本免疫学会学術集会, 10 Dec. 2018

  
• Hematopoietic cell-derived IL-15 supports the development and maintenance of NK, NKT and memory CD8 T cells in bone marrow

  Abe, S; Hara, T; Cui, G; Asahi, T; Ikuta, K

  第47回日本免疫学会学術集会, 10 Dec. 2018

  
• Local IL-15 dependency of liver-resident ILC1

  Asahi, T; Shimba, A; Cui, G; Abe, S; Zhu, Y; Ejima, A; Takami, D; Tani-ichi, S; Hara, T; Ikuta, K

  第47回日本免疫学会学術集会, 10 Dec. 2018

  
• Intestinal epithelial cell-derived IL-15 supports the homeostasis of intraepithelial lymphocytes

  Zhu, Y; Cui, G; Ikuta, K

  The 25th East Asia Joint Symposium on Biomedical Research, 26 Oct. 2018

  
• Competition between STAT5 and PI3K of IL-7R modulates T cell development and homeostasis

  Cui, G; Ikuta, K

  The 25th East Asia Joint Symposium on Biomedical Research, 26 Oct. 2018

  
• Glucocorticoids drive diurnal homing and response of T cells by inducing IL-7R and CXCR4

  生田宏一

  徳島大学医学研究科大学院セミナー, 27 Sep. 2018

  
• 胸腺内IL-15産生性免疫微小環境の機能解析

  崔広為; 生田宏一

  Kyoto T Cell Conference 第28回学術集会, 15 Jun. 2018

  
• Glucocorticoids drive diurnal oscillation in T cell distribution and response by inducing interleukin-7 receptor and chemokine receptor CXCR4

  Shimba, A; Cui, G; Tani-ichi, S; Ikuta, K

  The 16th International Student Seminar, 01 Mar. 2018

  
• Glucocorticoids drive diurnal homing and response of T cells by inducing IL-7R and CXCR4

  生田宏一

  福井大学医学研究科大学院セミナー, 19 Jan. 2018

  
• Competition between STAT5 and PI3K of the IL-7R modulates T cell and type 2 ILC development in vivo

  Cui, G; Shimba, A; Zhu, Y; Tani-ichi, S; Hara, T; Ikuta, K

  第46回日本免疫学会学術集会, 14 Dec. 2017

  
• Glucocorticoids drive diurnal changes in distribution and response of T cells via IL-7 receptor expression

  Shimba, A; Cui, G; Ikuta, K

  第46回日本免疫学会学術集会, 14 Dec. 2017

  
• Exploring the signals upregulating IL-7Ra expression via NFkB activation in T cells

  Tani-ichi, S; Ikuta, K

  第46回日本免疫学会学術集会, 14 Dec. 2017

  
• グルココルチコイドはIL-7受容体の発現を介してT細胞の体内分布および活性化の日内変動を制御する

  岡崎史恵; 榛葉旭恒; 崔広為; 生田宏一

  ConBio2017（生命科学系学会合同年次大会）, 06 Dec. 2017, Invited

  
• Osteoblasts mediate immunosuppression during sepsis by regulating lymphopoiesis

  Terashima, A; Okamoto, K; Nakashima, T; Ikuta, K; Takayanagi, H

  The 5th Annual Meeting of the International Cytokine and Interferon Society, 30 Oct. 2017

  
• Glucocorticoids drive diurnal homing and response of T cells via IL-7R expression

  生田宏一

  東京理科大学生命医科学研究所セミナー, 02 Aug. 2017, Invited

  
• IL-7Ra signaling upregulates growth hormone signaling-related gene in naive T cells

  Tani-ichi, S; Ikuta, K

  Keystone Symposium: Integrating Metabolism and Immunity, 01 Jun. 2017

  
• Glucocorticoids drive circadian changes in T-cell homing and response via IL-7 receptor

  Shimba, A; Ikuta, K

  Immunology 2017 (AAI), 15 May 2017

  
• Regulation of IL-7 receptor expression by a proximal enhancer

  Shimba, A; Cui, G; Tani-ichi, S; Hara, T; Ikuta, K

  KTCC 2017, 16 Mar. 2017

  
• Competitive signaling between STAT5 and PI3K of IL-7R modulates T cell development and homeostasis in vivo

  Cui, G; Shimba, A; Tani-ichi, S; Hara, T; Ikuta, K

  KTCC 2017, 16 Mar. 2017

  
• Identification of bone marrow IL-7 niche critical for B lymphopoiesis

  Hara, T; Ikuta, K

  KTCC 2017, 16 Mar. 2017

  
• Roles of IL-7 in development and response of the immune system.

  Ikuta, K

  The 11th International Symposium of the Institute Network, 27 Jan. 2017

  
• Immunodeficiency caused by sepsis-induced osteoblast ablation

  寺島明日香; 岡本一男; 審良静男; 生田宏一; 高柳広

  第45回日本免疫学会学術集会, Dec. 2016

  
• Local function of the IL-15 niche in thymus

  崔広為; 榛葉旭恒; 阿部真也; 朱媛博; 向平妃沙; 谷一靖江; 原崇裕; 生田宏一

  第45回日本免疫学会学術集会, Dec. 2016

  
• Identification of IL-15 niche for NK cells in bone marrow

  阿部真也; 原崇裕; 崔広為; 生田宏一

  第45回日本免疫学会学術集会, Dec. 2016

  
• Role of glucocorticoids in T cell homeostasis and T cell response

  榛葉旭恒; 崔広為; 阿部真也; 朱媛博; 向平妃沙; 谷一靖江; 原崇裕; 生田宏一

  The 23rd East Asia Joint Symposium, Oct. 2016

  
• Visualizing the immune microenvironment by reporter mice

  生田宏一

  富山大学医学研究科大学院セミナー, Oct. 2016

  
• Role of TCRγ enhancer ‘Eγ4’ for the development and function of γδ T cells

  谷一靖江; 生田宏一

  International Congress of Immunology 2016, Aug. 2016

  
• Roles of IL-7 in development and response of the immune system

  生田宏一

  サバンチ大学セミナー, Jun. 2016

  
• 骨髄におけるリンパ球分化を制御するIL-7産生ストローマ細胞の同定

  原崇裕; 生田宏一

  第26回Kyoto T Cell Conference, May 2016

  
• Competitive balance between STAT5 and PI3K signaling pathways of IL-7R modulates T cell development and homeostasis in vivo

  崔広為; 榛葉旭恒; 朱媛博; 小川真; 谷一靖江; 原崇裕; 生田宏一

  第26回Kyoto T Cell Conference, May 2016

  
• 腸管関連リンパ組織におけるIL-7ニッチの同定と特徴

  阿部真也; 原崇裕; 生田宏一

  BMB2015, Dec. 2015

  
• Regulation of IL-7R expression in dendritic cells

  谷一靖江; 生田宏一

  第44回日本免疫学会学術集会, Nov. 2015

  
• Differential roles of IL-7 and IL-2 receptor signals in lymphocyte differentiation and development revealed by IL-7Rα/IL-2Rβ chimera knock-in mice

  榛葉旭恒; 谷一靖江; 増田喬子; 崔広為; 小川真; 阿部真也; 原崇裕; 河本宏; 生田宏一

  第44回日本免疫学会学術集会, Nov. 2015

  
• STAT5 and PI3K signals of the IL-7R play differential roles in T cell development and homeostasis revealed by novel IL-7Rα mutant mice

  崔広為; 榛葉旭恒; 谷一靖江; 小川真; 阿部真也; 原崇裕; 生田宏一

  第44回日本免疫学会学術集会, Nov. 2015

  
• Identification and characterization of IL-7 niche in gut-associated lymphoid tissue

  原崇裕; 生田宏一

  第44回日本免疫学会学術集会, Nov. 2015

  
• Characterization of the IL-15 niche in vivo

  Cui, G; Hara, T; Simmons, S; Ishii, M; Tani-ichi, S; Ikuta, K

  The 6th FIMSA Congress, Jul. 2015

  
• グルココルチコイドはIL-7Rを誘導し、CXCR4を介したT細胞体内分布の日内変動を制御する

  榛葉旭恒; 谷一靖江; 生田宏一

  第25回Kyoto T Cell Conference, May 2015

  
• 末梢組織でのガンマデルタT細胞維持におけるTCRシグナルの必要性

  谷一靖江; 生田宏一

  第24回Kyoto T Cell Conference, May 2014

  
• 免疫微小環境の可視化と機能解析

  生田宏一

  第1回免疫代謝セミナー、富山、2014年7月31日, 2014

  
• Visualizing immune microenvironment by reporter mice

  生田宏一

  徳島大学疾患酵素学研究センターセミナー、徳島、2014年1月16日, 2014

  
• Distribution and function of IL-7- and IL-15-expressing cells in intestines

  原崇裕; 崔広為; 生田宏一

  第43回日本免疫学会学術集会、京都、2014年12月12日, 2014

  
• Approaches to identify Aire-regulated non-tissue-restricted antigen genes by the ectopic expression of Aire in thymic cortex

  西嶋仁; 森本純子; 毛利安宏; 河野弘; 生田宏一; 松本満

  第43回日本免疫学会学術集会、京都、2014年12月10日, 2014

  
• Differential roles of IL-7 and IL-2 receptor signals in lymphocyte development and maintenance revealed by IL-7Rα/IL-2Rβ chimera knock-in mice

  榛葉旭恒; 谷一靖江; 増田喬子; 原崇裕; 河本宏; 生田宏一

  第43回日本免疫学会学術集会、京都、2014年12月10日, 2014

  
• Identification and characterization of IL-15-expressing cells in vivo

  Cui, G; Hara, T; Simmons, S; Wagatsuma, K; Abe, A; Ishii, M; Tani-ichi, S; Ikuta, K

  The 9th International Symposium of the Institute Network, Osaka, June 19, 2014

  
• Distribution and function of IL-7-expressing cells in intestines

  原崇裕; 崔広為; 設楽宗一朗; 生田宏一

  第42回日本免疫学会学術集会、千葉、2013年12月11日, 2013

  
• Notch-RBP-Jκ-IL-7Rα pathway plays a pivotal role in the maintenance of IL-17-producing γδ T cells

  中村真隆; 柴田健輔; 山田久方; 生田宏一; 吉開泰信

  第42回日本免疫学会学術集会、千葉、2013年12月11日, 2013

  
• Role of a TCRγ enhancer, Eγ4, in differentiation and function of γδ T cell subsets

  谷一靖江; 我妻慶祐; 生田宏一

  第42回日本免疫学会学術集会、千葉、2013年12月11日, 2013

  
• Distribution and function of IL-7-expressing cells in large intestine

  Hara, T; Ikuta, K

  The 4th Workshop on Synthetic Immunology, Kyoto, November 16, 2013

  
• Identification and characterization of the IL-15-expressing cells in vivo

  Cui, G; Hara, T; Simmons, S; Wagatsuma, K; Tani-ichi, S; Ishii, M; Ikuta, K

  The 20th East Asia Joint Symposium on Global Medical Science for the 22th Century, Tokyo, November 7, 2013

  
• Visualizing the immune microenvironment by reporter mice

  Ikuta, K; Cui, G; Shitara, S; Liang, B; Tani-ichi, S; Hara, T

  The 20th East Asia Joint Symposium on Global Medical Science for the 22th Century, Tokyo, November 7, 2013

  
• Distribution and function of IL-7-expressing cells in the intestinal tissues

  Hara, T; Ikuta, K

  The 8th International Symposium of the Institute Network, Kyoto, June 27, 2013

  
• Differential roles of Jγ promoters and Eγ enhancers in controlling chromatin accessibility of the TCRγ locus by STAT5

  Wagatsuma, K; Tani-ichi, S; Shimba, A; Liang, B; Shitara, S; Hara, T; Ikuta, K

  The 6th International Workshop of Kyoto T Cell Conference 2013, Kyoto, June 4-5, 2013

  
• Visualization and characterization of IL-7- and IL-15-expressing cells in vivo

  Hara, T; Cui, G; Shitara, S; Tani-ichi, S; Ikuta, K

  The 6th International Workshop of Kyoto T Cell Conference 2013, Kyoto, June 4-5, 2013

  
• Visualization of the immune microenvironment by reporter mice

  Ikuta, K; Cui, G; Shitara, S; Liang, B; Tani-ichi, S; Hara, T

  The 6th International Workshop of Kyoto T Cell Conference 2013, Kyoto, June 7, 2013

  
• STAT5 motifs in the T cell receptor Jγ promoters control the local chromatin accessibility and rearrangements of the Jγ gene segments

  Wagatsuma, K; Tani-ichi, S; Liang, B; Shitara, S; Miyachi, H; Kitano, S; Kimura, H; Hara, T; Ikuta, K

  The 11th International Student Seminar, Kyoto, March 5-6, 2013

  
• Interleukin-7 produced by thymic epithelial cells plays a major role in the development of thymocytes and TCRγδ+ intraepithelial lymphocytes

  Shitara, S; Hara, T; Liang, B; Wagatsuma, K; Tani-ichi, S; Ikuta, K

  The 11th International Student Seminar, Kyoto, March 5-6, 2013

  
• Differential role of IL-7 and IL-2 receptor signals in development and maintenance of lymphocytes revealed by IL-7Rα/IL-2Rβ chimera knock-in mouse

  Shimba, A; Tani-ichi, S; Ikuta, K

  The 11th International Student Seminar, Kyoto, March 5-6, 2013

  
• Requirement of Aire expression within thymic medulla but not cortex for establishing self-tolerance

  西嶋仁; 森本純子; 毛利安宏; 西川裕美子; 生田宏一; 松本満

  第42回日本免疫学会学術集会、千葉、2013年12月11日, 2013

  
• Notch-RBP-JK-IL-7 receptor alpha axis is essential for the maintenance of IL- 17-producing ys T cells

  柴田健輔; 中村真隆; 山田久方; 生田宏一; 吉開泰信

  第41 回 日本免疫学会学術集会、神戸、2012 年12 月7 日, 2012

  
• Interleukin-7 produced by thymic epithelial cells controls development and maturation of thymocytes

  設楽宗一朗; 原崇裕; 生田宏一

  第41 回日本免疫学会学術集会、神戸、2012 年12 月6 日, 2012

  
• Visualization and characterization of IL-15-expressing cells in vivo by IL-15-CFP knock-in mice

  崔広為; 原崇裕; 我妻慶祐; 生田宏一

  第41 回日本免疫学会学術集会、神戸、2012 年12 月5 日, 2012

  
• Enhancers control locus-wide accessibility of the TCRy locus in vivo

  我妻慶祐; 谷一靖江; 生田宏一

  第41 回日本免疫学会学術集会、神戸、2012 年12 月5日, 2012

  
• Local function of IL-7 produced by hepatocytes.

  Liang B; Hara T; Wagatsuma K; Shitara S; Tani-ichi S; Ikuta K

  The 10th International Student Seminar, Kyoto, March 5-8, 2012 ・, 2012

  
• Distribution and function of IL-7-producing cells in lymphoid organs.

  Ikuta K; Hara T; Liang B; Cui G; Wagatsuma K; Tani-ichi S

  The Global COE Liaison Laboratory regular seminar, Kumamoto, July 18, 2012 ., 2012

  
• NFkB とAP-1 シグナルはCNS を介してIL-7R の発現レベルを制御する

  谷一靖江; 生田宏一

  第22 回Kyoto T Cell Conference 、京都、2012 年7 月6 日, 2012

  
• Distribution and function of IL-7-expressing cells in lymphoid organs.

  生田宏一

  岐阜大学医学研究科大学院セミナー, 岐阜, 2011年9月9日, 2011

  
• STAT motifs in Jγ promoters are essential for Vγ-Jγ rearrangements of Jγ gene segments.

  Wagatsuma K; Tani-ichi S; Ikuta K

  The 9th International Student Seminar, Kyoto, March 7-9, 2011., 2011

  
• リンパ管内皮細胞が産生するIL-7 は末梢T 細胞の組織分布を制御する

  原崇裕; 生田宏一

  第40 回日本免疫学会学術集会、千葉、2011 年11 月28 日, 2011

  
• JY プロモーターのSTAT モチーフ はJY 遺伝子断片のV-J 組換えに必須である

  我妻慶祐; 谷一靖江; 梁冰霏; 設楽宗一朗; 生田宏一

  第40 回日本免疫学会学術集会、千葉、 2011 年11 月27 日, 2011

  
• 腸管上皮内Y6T 細胞は胸腺に由来する

  設楽宗一朗; 梁冰霏; 原崇裕; 我妻慶祐; 生田宏一

  第40 回日本免疫学会学術集会、千葉、2011 年11 月27 日, 2011

  
• T 細胞分化後期におけるIL- フレセプターの役割

  谷一靖江; 生田宏一

  第40 回日本免疫学会学術集会、千葉、2011 年11 月27 日, 2011

  
• STAT5 はTCRJy プロモーターのSTAT モチーフを介してJY 遺伝子の組換えを制御する

  我妻慶祐; 谷一靖江; 梁冰霏; 生田宏一

  第84 回日本生化学会大会、京都、2011 年 9 月24 日, 2011

  
• 小腸上皮内Y6T 細胞は胸腺に由来する

  設楽宗一朗; 梁冰霏; 原崇裕; 生田宏一

  第21 回Kyoto T Cell Conference 、京都、2011 年6 月11 日, 2011

  
• T 細胞分化の後期におけるIL-7R の機能

  谷一靖江; 生田宏一

  第21 回Kyoto T Cell Conference 、京都、2011 年6 月10 日, 2011

  
• IL-7Ra 鎖遺伝子の近位エンハンサーは末梢T 細胞のIL- 7R の発現を制御する

  阿部昌史; 谷一靖江; 生田宏一

  第21 回Kyoto T Cell Conference 、京都、2011 年6 月10 日, 2011

  
• IL-7 signal controls differentiation of CD8 T cells and maintenance of peripheral T cells.

  Abe A; Tani-ichi S; Ikuta K

  The 14th International Congress of Immunology, Kobe, August 25, 2010, 2010

  
• リンパ組織におけるIL-7 産生細胞の分布と機能

  生田宏一

  三重大学医学研究科大学院セミナー, 津, 12 月14 日,2010., 2010

  
• Accessibility of the TCRy locus by a chromatin remodeling factor BRG1.

  Sumi C; Tani-ichi S; Ikuta K

  The 7th International Student Seminar, Kyoto, March 12, 2009 ・, 2009

  
• IL-7 産生ストローマ細胞のリンパ組織内分布

  原崇裕; 谷一靖江; 梁冰霏; 生田宏一

  第39 回日本免疫学会学術集会、大阪、12 月3 日、2009., 2009

  
• 胸線上皮細胞が産生するIL-7 の局所的役割

  生田宏一; 原崇裕; 梁冰霏; 谷一靖江

  第 39 回日本免疫学会学術集会、大阪、12 月2 日、2009., 2009

  
• BrglによるTCRy 遺伝子座の制御

  角知代; 谷一靖江; 生田宏一

  第5 回京都大学ウイル ス研究所学術交流会、京都, 22 Dec. 2008

  
• Stat5 によるTCRy 遺伝子座エンハンサー領域の制御

  谷一靖江; 佐竹正延; 生田宏一

  第 38 回日本免疫学会学術集会、京都、２００８年１２月２日, 2008

  
• Production of IL-7 by lymphocyte-stromal cell crosstalk

  SEKAI Miho; KINA Tatsuo; IKUTA Koichi

  第37 回日本免疫学会総会・学術集会（2007.11.20－22．東京）, 2007

  
• Control of the TCRγ Locus Accessibility by Stat5 and Histone Modifications.

  Ikuta. K

  The 14th East Asia Joint Symposium on Biomedical Research. The Institute of Medical Science, the University of Tokyo, Tokyo, November 13, 2007., 2007

  
• 転写因子IRF によるストローマ細胞のIL-7 産生機構

  瀬海美穂; 喜納辰夫; 生田宏一

  第17 回Kyoto T Cell Conference 学術集会（2007.6.15－16．京都）, 2007

  
• リンパ球とストローマ細胞の相互作用によるIL-7 の産 生誘導機構

  瀬海美穂; 喜納辰夫; 生田宏一

  第4 回京都大学ウイルス研究所学術交流会、京都、12 月20 日、2007., 2007

  
• Regulation of TCRy enhancer element by Stat5

  谷一靖江; 生田宏一

  第30 回日本分子生物学会年会/ 第80 回日本生化学会大会合同大会、横浜、12 月14 日、2007., 2007

  
• Bone marrow transplantation with newborn thymus grafts can rescue superlethally irradiated mice: possible role of IL-7-dependent mechanism.

  Hosaka N; Miyake T; Cui W; Nishida A; Takagi T; Inaba M; Ikuta K; Ikehara S

  第36 回日本免疫学会学術集会, 大阪, 12月12日, 2006., 2006

  
• Id2-deficient mice are susceptible to skin tumorigenesis but resistant to tumor proliferation.

  Tokuriki A; Ikuta K; Yokota Y

  The 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress, Kyoto, June 22, 2006., 2006

  
• 転写因子STAT 5 とRUNX ファミリーの会合と相互抑制

  小川伸哉; 佐竹正延; 生田宏一

  第3 回京都大 学ウイルス研究所学術交流会、京都、12 月21 日、2006, 2006

  
• I L7R シグナルによるMEK を介したTCRy 遺伝子座のVJ組換え制御機構の解析.

  真木一茂; 生田宏一

  第36 回日本免疫学会学術集会、大阪、12 月13 日、2006., 2006

  
• 肺炎球菌感染により活性化されたNKT 細胞とY6T 細胞におけるIFN-y 産生の解析

  八田益充; 仲松正司; 仲宗根力; 中村究; 宮里明子; 藤田次郎; 中山悛憲; 谷口克; 生田宏一; 賀来満夫; 川上和義

  第36 回日本免疫学会学術集会ワークショップ, 大阪,12 月12 日, 2006, 2006

  
• マウス樹状細胞におけるI L7 とTSLP の機能

  生田宏一

  第36 回日本免疫学会学術集会ワークショツ プ、大阪、12 月13 日、2006., 2006

  
• 転写因子によるTCR VY 遺伝子の組換え制御機構

  谷一靖江; 生田宏一

  第36 回日本免疫学会学術集会, 大阪,12 月12日, 2006., 2006

  
• グルココルチコイドによる未梢B 細胞のインターロイキンフ レセプター再発現機構の解析

  柴田寛文; 真木一茂; 生田宏一

  第2 回生命科学研究科・ウイルス研究所学生フェスティバル, 京都,10 月19 日, 2006., 2006

  
• 転写因子によるVy 遺伝子の特異的組換え制御機構

  谷一靖江; 林聡子; 玉置信行; 小寺香里; 坂本修士; 縣保年; 生田宏一

  第16 回Kyoto T Cell Conference 、京都,6 月3 日, 2006., 2006

  
• The IL-7 receptor controls the accessibility of the TCRγ locus by MAPK pathway

  Maki K; Hayashi S; Ikuta K

  The 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress, Kyoto, June 21, 2006., 2006

  
• Role of IL-7 receptor during lymphocyte development.

  Lee H. C; Shibata H; Ogawa S; Maki K; Ikuta K

  The 2nd RCAI Workshop "Epigenetic Regulation during Immune System Development", Yokohama, April 15, 2005., 2005

  
• Regulation of IL-7 receptor expression during T cell development.

  Ogawa S; Shibata H; Lee H. C; Maki K; Ikuta K

  The 4th International Workshop of Kyoto T Cell Conference, Kyoto, April 8, 2005., 2005

  
• TCRγ locus の組換えにおける転写因子STAT5 の関与

  谷一靖江; 生田宏一

  第2 回京都 大学ウイルス研究所学術交流会、京都、12 月16 日、2005., 2005

  
• STAT5 によるTCRγ 鎖V 領域の組換え誘導機構

  谷一靖江; 李海天; 生田宏一

  第35 回 日本免疫学会学術集会、横浜、12 月14 日、2005., 2005

  
• IL-7R シグナルによるMAP キナーゼを介したTCRγ 遺伝子座のV-J 組換え制御機構の解析

  真木一茂; 生田宏一

  第35 回日本免疫学会学術集会 ワークショップ、横浜、12 月 14 日、2005, 2005

  
• 肺炎球菌気道感染初期防御におけるγδ T 細胞の役割

  仲宗根力; 山本夏男; 仲松正司; 金城武士; 比嘉太; 石川博通; O'BRIEN Rebecca L; 生田 宏一; 藤田次郎; 川上和義

  第 35 回日本免疫学会学術集会 ワークショップ、横浜、12 月13 日、2005, 2005

  
• 免疫系の多様性獲得機構—エピジェネティクスでどこまでわかったのか

  生田宏一

  第 45 回 生化学若い研究者の会 夏の学校、シンポジウム、京都、8 月20 日、2005, 2005

  

Books and Other Publications

• Role of the IL-7 receptor in γδ T-cell development from hematopoietic stem cells

  Ikuta, K; Tani-ichi, S

  In “Hematopoietic Stem Cell Biology”. Kondo, M., ed. Humana Press Inc. pp143-159, 2009, Not refereed

  
• Developmental potential of fetal hematopoietic stem cells.

  Ikuta, K; Komagata, Y, Contributor

  In " Hematopoietic stem cells: Biology and therapeutic applications". Levitt, D. J., and Mertelsmann, R. eds. pp69-83., 1995, Not refereed

  

Awards

• 2002

  Japanese Society for Immunology, Japanese Society for Immunology Prize
• 2002

  日本免疫学会, 日本免疫学会賞

External funds: Kakenhi

• Induction of autoimmune diseases by glucocorticoids

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 49:Pathology, infection/immunology, and related fields

  Kyoto University

  Koichi IKUTA

  From 30 Jul. 2020, To 31 Mar. 2022, Project Closed

  グルココルチコイド;自己免疫疾患;Th17細胞;実験的自己免疫性脳脊髄炎;関節リウマチ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21525/
• IL-15-producing microenvironment supporting innate lymphoid cells and its role in diseases

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49070:Immunology-related

  Kyoto University

  Koichi Ikuta

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  自然免疫;サイトカイン;微小環境;IL-15;腫瘍免疫

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03501/
• Control of dynamics and function of T cells by glucocorticoids via IL-7 receptor expression

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Koichi Ikuta

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  ステロイド;T細胞;IL-7;概日リズム;内分泌系;適応免疫;糖質コルチコイド;免疫学;内科;感染症;生理学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15288/
• Control of innate immune cells, chronic inflammation and infection by cytokine-producing immune microenvironment

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Koichi IKUTA

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  リンパ球;生体分子;発生・分化;サイトカイン;ストローマ細胞;NK細胞;自然リンパ球;免疫学;感染症;リンパ組織;Tリンパ球;Bリンパ球;骨芽細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05172/
• サイトカイン産生性免疫微小環境の機能解析

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  生田 宏一

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  サイトカイン;リンパ組織;Tリンパ球;Bリンパ球;NK細胞;自然リンパ球;ストローマ細胞;骨芽細胞;免疫学;感染症;生体分子;発生・分化

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-15H01153/
• ＩＬ－１５産生性ストローマ細胞の局所機能の解明

  Grant-in-Aid for JSPS Fellows

  Kyoto University

  生田 宏一

  From 24 Apr. 2015, To 31 Mar. 2017, Project Closed

  サイトカイン;リンパ組織;Tリンパ球;NK細胞;NKT細胞;ストローマ細胞;血管内皮細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15F15114/
• Distribution and function of IL-15-producing cells in vivo

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Koichi IKUTA

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  免疫細胞;微小環境;サイトカイン;ストローマ細胞;IL-15;免疫組織

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460589/
• サイトカイン産生性免疫微小環境の可視化と機能解析

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  生田 宏一

  From 01 Apr. 2013, To 31 Mar. 2015, Project Closed

  免疫学;免疫組織;微小環境;サイトカイン;ストローマ細胞;IL-15

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-25111504/
• Distribution and function of IL-7-producing cells

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Koichi IKUTA

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  サイトカイン;IL-7;ストローマ細胞;小腸上皮内リンパ球;γδ T細胞;インターロイキン7;リンパ組織;遺伝子改変マウス;胸腺;NKT細胞;胸腺上皮細胞;GFP;T細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590531/
• Analysis of IL-7 receptor and application for biological protection

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Kazushige MAKI

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  サイトカイン;シグナル伝達;γδT細胞;グルココルチコイド;γδ T細胞;樹状細胞, Cytokine;Signal transduction;γδ T cell;Glucocorticold

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18580309/
• IL-7レセプターを指標としたB細胞記憶形成機構の解明

  Grant-in-Aid for Exploratory Research

  Kyoto University

  生田 宏一

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  インターロイキン;IL-7;IL-7レセプター;B細胞;グルココルチコイド;転写;免疫応答

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17659141/
• Role of IL-7 receptor in selection and memory formation of T cells

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Koichi IKUTA

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  T細胞;インターロイキン;IL-7;IL-レセプター;樹状細胞;免疫応答;補助刺激分子;IL-7レセプター, T cell;interleukin;IL-7;IL-7 receptor;dendritic cell;immune response;costimulatory molecule

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390143/
• IL-7レセプターの発現制御による免疫監視システムの形成と維持機構

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  生田 宏一

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  インターロイキン;IL-7;IL-7レセプター;樹状細胞;免疫応答;補助刺激分子;IL-7 レセプター

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17047021/
• IL-7レセプターの発現制御による免疫監視システムの形成と維持機構

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  生田 宏一

  From 01 Apr. 2004, To 31 Mar. 2005, Project Closed

  サイトカインレセプター;インターロイキン7;T細胞;T細胞抗原受容体;転写;グルココルチコイド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16043229/
• 転写因子Ikarosによる胸線T細胞の細胞周期と細胞死の制御

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  生田 宏一

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  サイトカインレセプター;インターロイキン7;T細胞;T細胞抗原受容体;転写;グルココルチコイド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16026217/
• リンパ系前駆細胞の生成過程におけるIL-7レセプターの機能

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  生田 宏一

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  サイトカインレセプター;インターロイキン7;T細胞;T細胞抗原受容体;転写;グルココルチコイド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15039218/
• 獲得免疫の成立過程におけるIL-7レセプターの機能

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  生田 宏一

  From 01 Apr. 2003, To 31 Mar. 2004, Project Closed

  サイトカインレセプター;インターロイキン7;T細胞;T細胞抗原受容体;転写

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15019046/
• ヒストン・メチル化によるTCRβ遺伝子座の対立遺伝子排除の制御

  Grant-in-Aid for Exploratory Research

  Kyoto University

  生田 宏一

  From 01 Apr. 2002, To 31 Mar. 2003, Project Closed

  サイトカインレセプター;Stat;γδT細胞;T細胞抗原受容体;シグナル伝達;DNA組換え;ヒストンアセチル化;転写共役因子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14657079/
• A transgenic model of Gcaves disease bearing human autoantibody genes

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Takashi AKAMIZU

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  バセドウ病;甲状腺機能亢進症;トランスジェニックマウス;TSHレセプター;トランスジェニックマウル;TSHレセプター抗体, Grave's disease;Autoimmune thyroid disease;Transgenic mouse;TSH receptor

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14370326/
• Recombination control of lymphocyte antigen receptor loci by chromati modification

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Koichi IKUTA

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  サイトカインレセプター;Stat;γδT細胞;T細胞抗原受容体;シグナル伝達;DNA組換え;ヒストンアセチル化;転写共役因子;サイトカイン;ヒストン修飾;クロマチン;サイトカインレセプタ, cytokine;Stat;γδ T cell;T cell antigen receptor;signal transduction;DNA recombination;histone modification;chromatin

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14370056/
• T細胞分化におけるIL-7レセプターによる細胞周期と細胞死の制御

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  生田 宏一

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  サイトカインレセプター;インターロイキン7;T細胞;T細胞抗原受容体;転写;シグナル伝達

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14033222/
• 獲得免疫の成立過程におけるIL-7レセプターの機能

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  生田 宏一

  From 01 Apr. 2002, To 31 Mar. 2003, Project Closed

  サイトカインレセプター;インターロイキン7;T細胞;T細胞抗原受容体;転写;シグナル伝達

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14021050/
• リンパ球の初期分化を誘導・制御するシグナル伝達機構

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tokyo Medical and Dental University

  烏山 一

  From 01 Apr. 2000, To 31 Mar. 2003, Project Closed

  B細胞分化;チロシンリン酸化;Btk;Sab;T細胞レセプター遺伝子;ヒストンアセチル化;抗原提示細胞;Ly49Q;シグナル伝達;PLCγ2;IL-7レセプター;マクロファージ活性化;プレB細胞レセプター;BLNK;サイトカイン;STAT;NK細胞;CD94

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12051243/
• Induction mechanism of V-J recombination by signaling molecules of the IL-7 receptor

  Grant-in-Aid for Scientific Research (B).

  KYOTO UNIVERSITY

  Koichi IKUTA

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  サイトカインレセプター;Stat;γδT細胞;シグナル伝達;DNA組換え;ヒストンアセチル化;転写共役因子;レトロウイルス;STAT;レトロウィルス, cytokine receptor;Stat;γδT cell;signal transduction;DNA recombination;histone acetylation;transcriptional coactivator;retrovirus

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11694264/
• Functional analysis of intracellular signaling molecules in T cell differentiation by IL-7 receptor-deficient mice

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Koichi IKUTA

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  サイトカインレセプター;Stat;γδT細胞;シグナル伝達;DNA組換え;ヒストンアセチル化;転写共役因子;レトロウイルス;STAT;レトロウィルス, cytokine receptor;Stat;γδ T cell;signal transduction;DNA recombination;histone acetylation;transcriptional coactivator;retrovirus

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11670317/
• IL-クレセプターによるTCRγ遺伝子のV-J組み換え誘導機構

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kyoto University

  生田 宏一

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  サイトカインレセプター;STAT;γδT細胞;シグナル伝達;レトロウィルス;DNA組換え;T細胞レセプター

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11148212/
• 造血細胞の遺伝子操作

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Biological Sciences

  Jichi Medical University

  小澤 敬也

  From 01 Apr. 1998, To 31 Mar. 2002, Project Closed

  遺伝子治療;造血幹細胞;選択的増幅遺伝子;コモンマーモセット;レトロウイルスベクター;突然変異マウス;サイトカインレセプター;トランスポゾンシステム;コンディショナルターゲティング;サイトカイン;V-J組換え;発作性夜間血色素尿症(PNH);ジーンターゲティング;ケモカイン;クローン優位性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10181105/
• IL-7レセプターによるTCRγ遺伝子のV-J組換え誘導機構

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kyoto University

  生田 宏一

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  STAT;サイトカインレセプター;V-J組換え;転写誘導

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10167209/
• Analysis of lymphpcyte differentiation and growth mechanism by IL-7 receptor deficient mice

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Koichi IKUTA

  From 01 Apr. 1997, To 31 Mar. 1999, Project Closed

  サイトカインレセプター;Bcl-2;γδT細胞;トランスジェニックマウス;サイトカイン;T細胞, IL-7 receptor;Bcl-2;gammadelta T cell;transgenic mouse

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09836005/
• IL-7レセプター欠失マウスによるリンパ球初期分化機構の解析

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  生田 宏一

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  サイトカイン;レセプター;標的遺伝子組み換え;T細胞;トランスジェニックマウス;胸腺

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08839004/
• マウス発生工学によるc-mplとトロンボポイエチンを介した巨核球増殖機構の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  The University of Tokyo

  生田 宏一

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  癌遺伝子;巨核球;トロンボポイエチン;トランスジェニックマウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07272211/
• 胚幹細胞への欠失変異導入法の開発

  Grant-in-Aid for Scientific Research on Priority Areas

  Tohoku University

  宮崎 純一

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  ノックアウトマウス;ジーンターゲッティング;ES細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07260201/
• 標的遺伝子組み換えと胚盤胞相補法によるサイトカイン受容体遺伝子の機能解析

  Grant-in-Aid for General Scientific Research (C)

  The University of Tokyo

  生田 宏一

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  IL-7レセプター;標的遺伝子組み換え;マウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06670345/
• 標的遺伝子組み換えによる造血幹細胞の新しい受容体型癌遺伝子c-mplの解析

  Grant-in-Aid for Scientific Research on Priority Areas

  The University of Tokyo

  生田 宏一

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  標的遺伝子組み換え;サイトカイン・レセプター;マウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06280209/
• 胎児期造血幹細胞のストローマ細胞による増幅と分化能の変化

  Grant-in-Aid for Scientific Research on Priority Areas

  The University of Tokyo

  生田 宏一

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  造血幹細胞;胎児胸腺器官培養;T細胞レセプター;RT-PCR;N配列

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06277205/
• 胚幹細胞への欠失変異導入法の開発

  Grant-in-Aid for Scientific Research on Priority Areas

  Tohoku University

  宮崎 純一

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  標的組み換え法;胚幹細胞;ノックアウトマウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06268204/
• 造血幹細胞レベルでのT細胞レセプターN配列挿入の調節機構

  Grant-in-Aid for General Scientific Research (C)

  The University of Tokyo

  生田 宏一

  From 01 Apr. 1993, To 31 Mar. 1994, Project Closed

  造血幹細胞;T細胞レセプター;γδ型T細胞;N配列;胸腺;PCR

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05807027/
• 胚幹細胞への欠失変異導入法の開発

  Grant-in-Aid for Scientific Research on Priority Areas

  The University of Tokyo

  宮崎 純一

  From 01 Apr. 1993, To 31 Mar. 1994, Project Closed

  胚幹細胞;ジーンターゲッティング;変異導入

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05275204/
• Control of immune response and tissue homeostasis by novel IL-15-dependent subsets of innate lymphocytes and lymphoid cells

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49070:Immunology-related

  Kyoto University

  生田 宏一

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  自然免疫;サイトカイン;微小環境;腫瘍免疫;抗ウイルス免疫応答

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02735/
• Control of immune response and tissue homeostasis by novel IL-15-dependent innate lymphocytes

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49070:Immunology-related

  Kyoto University

  生田 宏一

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  自然免疫;サイトカイン;微小環境;腫瘍免疫;抗ウイルス免疫応答

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27426/
• The mechanism how adipose tissue M2 macrophages regulate insulin sensitivity

  Grant-in-Aid for Scientific Research (B)

  Basic Section 54040:Metabolism and endocrinology-related

  University of Toyama

  戸邉 一之

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  2型糖尿病;インスリン抵抗性;肥満;M2マクロファージ;脂質関連マクロファージ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02502/

External funds: others

• argeting transcription factor binding sites of the interleukin 7 receptor gene using genome editing

  二国間交流事業共同研究・セミナー

  From 01 Apr. 2015, To 31 Mar. 2016

  生田　宏一
• Targeting transcription factor binding sites of the interleukin 7 receptor gene using genome editing

  二国間交流事業共同研究・セミナー

  From 01 Apr. 2016, To 31 Mar. 2017

  生田　宏一
• Targeting transcription factor binding sites of the interleukin 7 receptor gene using genome editing

  二国間交流事業共同研究・セミナー

  From 01 Apr. 2017, To 31 Aug. 2017

  生田　宏一
• ゲノム改変によるインターロイキン７レセプター発現制御機構の解析 （平成29年度分）

  二国間交流事業共同研究・セミナー

  From 01 Apr. 2017, To 31 Mar. 2018

  生田 宏一

Education

Teaching subject(s)

• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Basic Molecular Biology

  4204, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Basic Molecular Biology

  4204, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Immunology, Allergy and Infection (Practice)

  P006, Year-long, Graduate School of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Immunology, Allergy and Infection (Practice for Master Program)

  E039, Year-long, Graduate School of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Immunology I

  8014, Fall, Faculty of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Basic Molecular Biology

  3204, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Basic Molecular Biology

  3204, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Immunology, Allergy and Infection (Seminar)

  P005, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Immunology, Allergy and Infection (Seminar for Master Program)

  E038, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Infection and Host Defense I

  C216, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Infection and Host Defense 2

  A217, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Infection and Host Defense 1

  A216, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Infection and Host Defense II

  C217, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Molecular Biology Seminar

  2304, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Molecular Biology Seminar

  2304, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Biological Chemistry

  1207, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Biological Chemistry

  1207, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Immunology, Allergy and Infection (Practice for Master Program)

  E039, Year-long, Graduate School of Medicine, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Immunology, Allergy and Infection (Seminar for Master Program)

  E038, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Infection and Host Defense 2

  A217, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Infection and Host Defense 1

  A216, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Basic Molecular Biology

  3204, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Pharmaceutical Biochemistry

  8103, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Immunology I

  8014, Fall, Faculty of Medicine, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Practice in Basic Molecular Biology

  4204, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Immunology, Allergy and Infection (Seminar)

  P005, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Modern Life Sciences for Drug Discovery

  1027, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Infection and Host Defense I

  C216, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Molecular Biology Seminar

  2304, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Immunology, Allergy and Infection (Practice)

  P006, Year-long, Graduate School of Medicine, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Molecular Genetics II

  3726, Spring, Faculty of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Infection and Host Defense II

  C217, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Laboratory Techniques in Biological Chemistry

  1207, Spring, Graduate School of Pharmaceutical Sciences, 2
• From Apr. 2011, To Mar. 2012

  分子遺伝学II

  Spring, 理学部
• From Apr. 2011, To Mar. 2012

  Virus and Life Science

  Fall, 全学共通科目
• From Apr. 2011, To Mar. 2012

  The Front Line of Life Science Research I

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2012, To Mar. 2013

  Virus and Life Science

  Fall, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2013, To Mar. 2014

  Virus and Life Science

  Fall, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2014, To Mar. 2015

  Virus and Life Science

  Fall, 全学共通科目
• From Apr. 2014, To Mar. 2015

  The Front Line of Life Science Research I

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  The Front Line of Life Science Research II

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2015, To Mar. 2016

  Virus and Life Science

  Fall, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Immunology, Allergy and Infection (Practice)

  Year-long, 医学研究科
• From Apr. 2016, To Mar. 2017

  Immunology, Allergy and Infection (Seminar)

  Year-long, 医学研究科
• From Apr. 2016, To Mar. 2017

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2017, To Mar. 2018

  Immunology, Allergy and Infection (Practice)

  Year-long, 医学研究科
• From Apr. 2017, To Mar. 2018

  Immunology, Allergy and Infection (Seminar)

  Year-long, 医学研究科
• From Apr. 2017, To Mar. 2018

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2017, To Mar. 2018

  Infection and Host Defense 1

  Spring, 薬学部
• From Apr. 2018, To Mar. 2019

  Immunology I

  Fall, 医学部（人間健康科学科）
• From Apr. 2018, To Mar. 2019

  Immunology, Allergy and Infection (Practice)

  Year-long, 医学研究科
• From Apr. 2018, To Mar. 2019

  Immunology, Allergy and Infection (Seminar)

  Year-long, 医学研究科
• From Apr. 2018, To Mar. 2019

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2018, To Mar. 2019

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Introduction in Medical Science

  Spring, 医学研究科
• From Apr. 2018, To Mar. 2019

  Infection and Host Defense 1

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Immunology II

  Spring, 医学部（人間健康科学科）
• From Apr. 2019, To Mar. 2020

  Immunology I

  Fall, 医学部（人間健康科学科）
• From Apr. 2019, To Mar. 2020

  Immunology, Allergy and Infection (Practice for Master Program)

  Year-long, 医学研究科
• From Apr. 2019, To Mar. 2020

  Immunology, Allergy and Infection (Seminar for Master Program)

  Year-long, 医学研究科
• From Apr. 2019, To Mar. 2020

  Immunology, Allergy and Infection (Practice)

  Year-long, 医学研究科
• From Apr. 2019, To Mar. 2020

  Immunology, Allergy and Infection (Seminar)

  Year-long, 医学研究科
• From Apr. 2019, To Mar. 2020

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2019, To Mar. 2020

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Infection and Host Defense II (Immunology and Virology)

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Infection and Host Defense 1

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Infection and Host Defense 2

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Infection and Host Defense I (Microbiology and Virology)

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Immunology II

  Spring, 医学部（人間健康科学科）
• From Apr. 2020, To Mar. 2021

  Immunology I

  Fall, 医学部（人間健康科学科）
• From Apr. 2020, To Mar. 2021

  Immunology, Allergy and Infection (Practice for Master Program)

  Year-long, 医学研究科
• From Apr. 2020, To Mar. 2021

  Immunology, Allergy and Infection (Seminar for Master Program)

  Year-long, 医学研究科
• From Apr. 2020, To Mar. 2021

  Immunology, Allergy and Infection (Practice)

  Year-long, 医学研究科
• From Apr. 2020, To Mar. 2021

  Immunology, Allergy and Infection (Seminar)

  Year-long, 医学研究科
• From Apr. 2020, To Mar. 2021

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2020, To Mar. 2021

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Infection and Host Defense II (Immunology and Virology)

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Infection and Host Defense 1

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Infection and Host Defense 2

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Infection and Host Defense I (Microbiology and Virology)

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From 01 Apr. 2020, To 31 Mar. 2021

  B8免疫学

  医学研究科
• From Apr. 2021, To Mar. 2022

  Immunology II

  Spring, 医学部（人間健康科学科）
• From Apr. 2021, To Mar. 2022

  Immunology I

  Fall, 医学部（人間健康科学科）
• From Apr. 2021, To Mar. 2022

  Immunology, Allergy and Infection (Practice for Master Program)

  Year-long, 医学研究科
• From Apr. 2021, To Mar. 2022

  Immunology, Allergy and Infection (Seminar for Master Program)

  Year-long, 医学研究科
• From Apr. 2021, To Mar. 2022

  Immunology, Allergy and Infection (Practice)

  Year-long, 医学研究科
• From Apr. 2021, To Mar. 2022

  Immunology, Allergy and Infection (Seminar)

  Year-long, 医学研究科
• From Apr. 2021, To Mar. 2022

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2021, To Mar. 2022

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Laboratory Practice in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Basic Molecular Biology

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Molecular Biology Seminar

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Biological Chemistry

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Biological Chemistry

  Fall, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Infection and Host Defense I

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Infection and Host Defense II

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Infection and Host Defense 1

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Infection and Host Defense 2

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科

Participation in PhD Defense

• 気道炎症における2型自然リンパ球の維持及び活性化に対する局所インターロイキン7の機能に関する研究

  TAKAMI DAICHI, Graduate School of Pharmaceutical Sciences, Chief Examiner

  23 Mar. 2023
• ATM suppresses c-Myc overexpression in the mammary epithelium in response to estrogen

  Rifat Ara Najnin, Graduate School of Medicine, Chief Examiner

  23 Mar. 2023
• Self-assembling small-molecule adjuvants as antigen nano-carriers

  Shuyu Jin, Graduate School of Medicine, Chief Examiner

  23 Mar. 2023
• Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation

  ISA MASAHIKO, Graduate School of Medicine, Chief Examiner

  23 Mar. 2023
• 臨床ビッグデータ解析及び薬理学的実証によるジペプチジルペプチダーゼ4阻害薬誘発類天疱瘡抑制法の創出

  NOZAWA KEISUKE, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2023
• シングルセルトランスクリプトーム解析を駆使したウイルス感染に対する動物種特異的自然免疫応答の同定

  ASO HIROFUMI, Graduate School of Pharmaceutical Sciences, Chief Examiner

  23 Mar. 2023
• Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase

  IIBUSHI JUNPEI, Graduate School of Medicine, Chief Examiner

  23 Mar. 2023
• 血管性認知障害におけるグリア細胞の病態生理学的役割の解明

  KAKAE MASASHI, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2023
• オリゴデンドロサイト前駆細胞の制御機構および病態時の機能に関する研究

  OHASHI KANA, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2023
• ABIN1 is a signal‐induced autophagy receptor that attenuates NF‐kB activation by recognizing linear ubiquitin chains

  SHINKAWA YUTAKA, Graduate School of Medicine, Chief Examiner

  26 Sep. 2022
• Role of the RNA binding protein Musashi2 in myogenesis

  Wang Ruochong, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  26 Sep. 2022
• Circadian rhythm affects the magnitude of contact hypersensitivity response in mice

  MIYAKE TOSHIYA, Graduate School of Medicine, Chief Examiner

  25 Jul. 2022
• Alteration of the immune environment in bone marrow from children with recurrent B cell precursor acute lymphoblastic leukemia

  MIKAMI TAKASHI, Graduate School of Medicine, Sub-chief Examiner

  23 May 2022
• Increased expression of programmed cell death ligand 1 and galectin 9 in transplant recipients who achieved tolerance after immunosuppression withdrawal

  NGUYEN HAI NAM, Graduate School of Medicine, Chief Examiner

  23 Mar. 2022
• High programmed death ligand 1 expression in carcinomatous components predicts a poor prognosis in pulmonary pleomorphic carcinoma

  NOGUCHI MISA, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• Identification of CXCL12-abundant reticular cells in human adult bone marrow

  AOKI KAZUNARI, Graduate School of Medicine, Chief Examiner

  24 Sep. 2021
• CCL2-CCR2 signaling in the skin drives surfactant-induced irritant contact dermatitis via IL-1β-mediated neutrophil accumulation

  SHIBUYA RINTARO, Graduate School of Medicine, Sub-chief Examiner

  24 Nov. 2021

Student achievements: Awards

• 井上研究奨励賞

  Sang-Kyu Ye, 井上科学振興財団, 2003
• 井上研究奨励賞

  榛葉旭恒, 井上科学振興財団, 04 Feb. 2019

Administration

School management (title, position)

• From 01 Apr. 2022, To 31 Mar. 2024

  大学評価委員会点検・評価実行委員会 委員
• From 01 Apr. 2022, To 31 Mar. 2024

  大学評価委員会 委員
• From 01 Apr. 2008, To 30 Sep. 2010

  京都大学動物実験委員会 委員
• From 01 Apr. 2008, To 31 Mar. 2009

  放射性同位元素等管理委員会 委員
• From 01 Apr. 2011, To 31 Mar. 2013

  図書館協議会　協議員
• From 01 Apr. 2011, To 31 Mar. 2013

  医学図書館運営委員会　委員
• 次世代研究者育成センター専門委員会　委員
• From 01 Apr. 2011, To 31 Mar. 2013

  ウイルス研究所衛生管理者
• From 01 Jul. 2013, To 30 Jun. 2015

  国際交流委員会 委員
• From 21 Apr. 2015, To 13 May 2015

  京都大学研究公正推進委員会　研究データ保存のルール制定の作業部会
• From 16 May 2017

  研究活動上の行動規範に関する検討ワーキンググループ 委員
• From 16 May 2017, To 31 Mar. 2018

  研究活動上の行動規範に関する検討ワーキンググループ 委員
• From 01 Apr. 2018, To 31 Mar. 2020

  京都大学研究戦略タスクフォース　プログラムオフィサー
• From 01 Oct. 2016, To 30 Sep. 2018

  医学研究科運営委員会
• From 01 Jul. 2017, To 30 Jun. 2018

  京都大学白眉センター伯楽会議　委員
• From 28 Oct. 2020, To 30 Sep. 2022

  研究戦略タスクフォース プログラムオフィサー

Faculty management (title, position)

• From 01 Apr. 2023

  自己点検・評価委員会　委員
• From 01 Apr. 2022

  業績評価委員会　委員
• From 01 Jul. 2021

  感染症モデル研究センター運営委員会 委員
• From 01 Apr. 2014

  共同利用機器等委員会　委員
• From 01 Apr. 2021, To 31 Mar. 2022

  自己点検・評価委員会　委員長
• From 01 Oct. 2016

  人権委員会　委員
• From 01 Oct. 2016

  動物実験委員会　委員
• From 01 Apr. 2018, To 31 Mar. 2022

  ウイルス・再生医科学研究所　副所長
• From 01 Apr. 2009, To 31 Mar. 2013

  広報委員会　委員
• From 01 Apr. 2011, To 31 Mar. 2012

  職員等配置検討委員会　委員
• From 01 Apr. 2010, To 31 Mar. 2012

  図書委員会　委員長
• From 27 Sep. 1993, To 31 Mar. 1995

  コンピュータ・ネットワーク委員会　委員
• From 01 Apr. 2010, To 31 Mar. 2012

  自己点検・評価委員会　委員
• From 01 Apr. 2010, To 31 Mar. 2012

  動物実験委員会　委員
• From 01 Apr. 2011, To 31 Mar. 2012

  共同利用機器等委員会　委員
• From 01 Apr. 2010, To 31 Mar. 2012

  霊長類小委員会
• From 01 Apr. 2011, To 31 Mar. 2013

  病原体安全管理委員会　委員
• From 01 Apr. 2011, To 31 Mar. 2013

  安全衛生委員会　委員
• From 01 Apr. 2014, To 31 Mar. 2021

  予算委員会　委員
• From 01 Apr. 2013, To 31 Mar. 2015

  教育委員会　委員
• From 01 Apr. 2014, To 31 Mar. 2016

  動物実験委員会　委員長
• From 01 Apr. 2015, To 31 Mar. 2017

  職員等配置検討委員会　委員
• From 01 Apr. 2014, To 31 Mar. 2016

  図書委員会　委員
• From 01 Apr. 2014, To 31 Mar. 2018

  自己点検・評価委員会　委員
• 安全衛生委員会　委員
• From 01 Oct. 2016, To 30 Jun. 2021

  ウイルス動物実験専門委員会　委員
• From 01 Oct. 2016, To 31 Mar. 2018

  （旧ウイルス研）共同利用機器等委員会　委員

Academic, Social Contribution

Committee Memberships

• From 2003, To Present

  評議員, 日本生化学会
• From 1997, To Present

  評議員, 日本免疫学会
• From 2005, To 2010

  学会のあり方検討委員会委員, 日本免疫学会
• From 2000, To 2005

  教育推進委員会委員, 日本免疫学会