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Shintaku, Hirofumi

Institute for Life and Medical Sciences (LiMe) Professor

Shintaku, Hirofumi
list
    Last Updated :2025/05/24

    Basic Information

    Affiliated programs (koza)

    • Graduate School of Engineering, マイクロエンジニアリング専攻　ナノ生物工学, 教授

    Faculty

    • Faculty of Engineering

    Professional Memberships

    • THE BIOPHYSICAL SOCIETY OF JAPAN
    • THE INSTITUTE OF ELECTRICAL ENGINEERS OF JAPAN
    • THE JAPAN SOCIETY OF MECHANICAL ENGINEERS

    Academic Degree

    • 23 Mar. 2004
      京都大学修士（工学）
    • 25 Sep. 2006
      京都大学博士（工学）

    Academic Resume (Graduate Schools)

    • 京都大学, 大学院工学研究科博士後期課程機械工学専攻, 修了
    • 京都大学, 大学院工学研究科修士課程機械工学専攻, 修了

    Academic Resume (Undergraduate School/Majors)

    • 京都大学, 工学部物理工学科, 卒業

    High School

    • High School

      広島大学附属福山高等学校

    Research History

    • From Sep. 2012, To Sep. 2015
      Stanford University, Department of Mechanical Engineering, Visiting Scholar
    • From Apr. 2023, To Present
      Kyoto University, Institute for Life and Medical Sciences, Professor
    • From Apr. 2018, To Mar. 2025
      RIKEN, Cluster for Pioneering Research, RIKEN Hakubi Team Leader
    • From Apr. 2012, To Mar. 2018
      Kyoto University, Graduate School of Engineering, Assistant Professor
    • From Apr. 2007, To Mar. 2012
      Osaka University, Graduate School of Engineering Science, Assistant Professor
    • From Oct. 2006, To Mar. 2007
      Osaka University, Graduate School of Engineering Science, Research Associate
    • From Apr. 2004, To Sep. 2006
      JSPS, Research Fellow

    ID,URL

    researchmap URL

    list
      Last Updated :2025/05/24

      Research

      Research Interests

      • RNA
      • Single cell
      • Microfluidics
      • MEMS
      • Fluid Engineering

      Research Areas

      • Nanotechnology/Materials, Nanobioscience
      • Life sciences, Biophysics
      • Manufacturing technology (mechanical, electrical/electronic, chemical engineering), Fluid engineering, Microfluidics

      Papers

      • マイクロ・ナノ電気穿孔を用いた1細胞ダイナミクス分析
        新宅 博文
        年次大会, 2021
      • Aqueous Two-Phase System(ATPS)による異種モータタンパク質のパターニングとその評価
        中川 倫宏; 大原 駿平; 小寺 秀俊; 新宅 博文; 横川 隆司
        バイオエンジニアリング講演会, Jan. 2018
      • オンチップ血管網での剪断応力知覚による血管新生の評価
        寺岡 佑佳子; 西山 功一; 三浦 岳; 横川 隆司; 中山 雅宗; 梨本 裕司; 中益 朗子; 花田 三四郎; 有馬 勇一郎; 鳥澤 勇介; 新宅 博文; 小寺 秀俊
        バイオエンジニアリング講演会, Jan. 2018
      • 金ナノピラーとSAMを用いた等間隔でのダイニンの配置
        大庭 將太郎; 金子 泰洸ポール; 新宅 博文; 小寺 秀俊; 横川 隆司
        バイオエンジニアリング講演会, Jan. 2018
      • FLUORESCENT OBSERVATION OF ATP BINDING IN KINESIN DRIVEN MICROTUBULE GLIDING USING NANO-SLITS
        Kazuya Fujimoto; Ryota Iino; Michio Tomishige; Hirofunii Shintaku; Hidetoshi Kotera; Ryuji Yokokawa
        2018 IEEE MICRO ELECTRO MECHANICAL SYSTEMS (MEMS), 2018, Peer-reviewed
      • Microtubule Sorting by Persistence Length and Surface Charge Density of Microtubules
        Naoto Isozaki; Hirofumi Shintaku; Hidetoshi Kotera; Taviare L. Hawkins; Jennifer L. Ross; Ryuji Yokokawa
        BIOPHYSICAL JOURNAL, Feb. 2017, Peer-reviewed
      • 一細胞RNA網羅解析に向けたribosomal RNA除去法の開発
        土田 新; 畑 翔太; 横川 隆司; 小寺 秀俊; 新宅 博文
        年次大会, Jan. 2017
      • ナノメートル精度の画像解析を用いた微小管の曲げ剛性と伸長速度の評価
        浮田 一輝; 磯崎 直人; 新宅 博文; 小寺 秀俊; Taviare L. Hawkins; Jennifer L. Ross; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], Jan. 2017, Peer-reviewed
      • 金ナノピラーとSAMによるモータタンパク質パターニング技術の開発
        大庭 將太郎; 金子 泰洸ポール; 新宅 博文; 小寺 秀俊; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], Jan. 2017, Peer-reviewed
      • Linear-shaped Zero Mode Waveguidesの設計・製作とそれを用いたキネシンおよびATPの1分子観察 (第33回「センサ・マイクロマシンと応用システム」シンポジウム受賞論文特集)
        藤本 和也; 森田 有貴; 飯野 亮太; 富重 道雄; 新宅 博文; 小寺 秀俊; 横川 隆司
        電気学会論文誌. E, センサ・マイクロマシン部門誌 = IEEJ transactions on sensors and micromachines, Jan. 2017, Peer-reviewed
      • 3D血管網を用いた剪断応力の知覚と伝達による血管新生評価システム
        寺岡 佑佳子; 中山 雅宗; 梨本 裕司; 中益 朗子; 花田 三四郎; 有馬 勇一郎; 鳥澤 勇介; 新宅 博文; 小寺 秀俊; 西山 功一; 三浦 岳; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], Jan. 2017, Peer-reviewed
      • 分子パターニングを用いたキネシンの協働性の評価
        金子 泰洸ポール; 大庭 將太郎; 新宅 博文; 小寺 秀俊; 横川 隆司; 古田 健也; 大岩 和弘
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], Jan. 2017, Peer-reviewed
      • キネシンによる微小管運動における蛍光ATP結合・解離のLZMWsを用いた1分子観察
        藤本 和也; 飯野 亮太; 富重 道雄; 新宅 博文; 小寺 秀俊; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], Jan. 2017, Peer-reviewed
      • ATPSを用いた異種モータタンパク質の選択的固定とその評価
        中川 倫宏; 大原 駿平; 新宅 博文; 小寺 秀俊; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], Jan. 2017, Peer-reviewed
      • A microfluidic system for integrated analyses on nuclear and cytoplasmic nucleic acids of single cells
        Hirofumi Shintaku
        2017 IEEE 12TH INTERNATIONAL CONFERENCE ON NANO/MICRO ENGINEERED AND MOLECULAR SYSTEMS (NEMS), 2017, Peer-reviewed
      • NANO-PATTERNING OF MOTOR PROTEINS TO CONTROL NUMBER OF KINESIN MOLECULES TRANSPORTING A SINGLE MICROTUBULE
        Taikopaul Kaneko; Hirofumi Shintaku; Hidetoshi Kotera; Ryuji Yokokawa
        30TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2017), 2017, Peer-reviewed
      • LINEAR ZERO MODE WAVEGUIDES FOR THE STUDY OF CHEMO-MECHANICAL COUPLING MECHANISM OF KINESIN
        Kazuya Fujimoto; Yuki Morita; Ryota Iino; Michio Tomishige; Hirofumi Shintaku; Hidetoshi Kotera; Ryuji Yokokawa
        30TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2017), 2017, Peer-reviewed
      • Controlling Gliding Trajectories of Microtubules by Altering Microtubule Flexural Rigidity
        Naoto Isozaki; Scott Erickson; Shintaku Hirofumi; Hidetoshi Kotera; Taviare L. Hawkins; Jennifer L. Ross; Ryuji Yokokawa
        BIOPHYSICAL JOURNAL, Feb. 2016, Peer-reviewed
      • マイクロオリフィスを用いた一細胞RNAおよびDNA同時前処理法
        新宅 博文; 藁谷 卓哉; 小口 祐伴; 上村 想太郎
        年次大会, Jan. 2016
      • 圧力駆動流によるオンチップ血管新生の促進
        中山 雅宗; 梨本 裕司; 國田 樹; 中益 朗子; 鳥澤 勇介; 新宅 博文; 小寺 秀俊; 西山 功一; 三浦 岳; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], Jan. 2016, Peer-reviewed
      • 電荷と曲げ剛性の同時改変による高精度な微小管分離
        磯崎 直人; 新宅 博文; 小寺 秀俊; Taviare L. Hawkins; Jennifer L. Ross; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], Jan. 2016, Peer-reviewed
      • 等速電気泳動を用いた一細胞スケールRNA抽出における効率の評価
        畑 翔太; Atta Mahmoud Nady Abdel-Moez; 横川 隆司; 小寺 秀俊; 新宅 博文
        年次大会, Jan. 2016
      • LZMWを用いたキネシンによるATP加水分解サイクルの可視化
        藤本 和也; 森田 有貴; 飯野 亮太; 富重 道雄; 新宅 博文; 小寺 秀俊; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], Jan. 2016, Peer-reviewed
      • Single-molecule Fluorescence Imaging of Kinesin Using Linear Zero-Mode Waveguides
        Yuki Morita; Kazuya Fujimoto; Ryota Iino; Michio Tomishige; Hirofumi Shintaku; Hidetoshi Kotera; Ryuji Yokokawa
        2016 IEEE SENSORS, 2016, Peer-reviewed
      • ダイナミックマイクロチャネルと数値解析を用いたキネシンによる能動輸送の評価
        藤本 和也; 新宅 博文; 小寺 秀俊; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], Jan. 2015, Peer-reviewed
      • マルチモータ解析のためのマイクロチャネルを用いた異種モータタンパク質の選択的固定
        尾田 文恵; 森田 充樹; 新宅 博文; 小寺 秀俊; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], Jan. 2015, Peer-reviewed
      • J0540101 電気穿孔および等速電気泳動を用いた一細胞cytoplasmic RNA抽出法における純度計測
        畑 翔太; 横川 隆司; 小寺 秀俊; 新宅 博文
        年次大会 : Mechanical Engineering Congress, Japan, Jan. 2015
      • ON-CHIP DETECTION OF WILD 3R, 4R AND MUTANT 4R TAU THROUGH KINESIN-MICROTUBULE BINDING
        S. P. Subramaniyan; M. C. Tarhan; S. L. Karsten; H. Fujita; H. Shintaku; H. Kotera; R. Yokokawa
        2015 28TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2015), 2015, Peer-reviewed
      • MICROTUBULE SORTIING WITHIN A GIVEN ELECTRIC FIELD BY DESIGNING FLEXURAL RIGIDITY
        Naoto Isozaki; Hirofumi Shintaku; Hidetoshi Kotera; Edgar Meyhoefer; Ryuji Yokokawa
        2015 28TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2015), 2015, Peer-reviewed
      • 微小管の運動方向制御のための曲げ剛性設計
        磯崎 直人; 新宅 博文; 小寺 秀俊; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], Jan. 2015, Peer-reviewed
      • A METHOD FOR CONTROLLING MICROTUBULE VELOCITY USING LIGHT IRRADIANCE ON A PATTERNED GOLD SURFACE
        Tasuku Nakahara; Hirofumi Shintaku; Hidetoshi Kotera; Ryuji Yokokawa
        2015 28TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2015), 2015, Peer-reviewed
      • VASCULAR NETWORK FORMATION FOR A LONG-TERM SPHEROID CULTURE BY CO-CULTURING ENDOTHELIAL CELLS AND FIBROBLASTS
        Tomoya Hayashi; Hisako Takigawa-Imamura; Koichi Nishiyama; Hirofumi Shintaku; Hidetoshi Kotera; Takashi Miura; Ryuji Yokokawa
        2015 28TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2015), 2015, Peer-reviewed
      • 動的に形成されるマイクロチャネルによる微小管グライディング制御
        藤本 和也; 新宅 博文; 小寺 秀俊
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], Jan. 2014, Peer-reviewed
      • 微小管の運動方向制御に向けた電気泳動移動度及びキネシン間距離の制御
        安藤 駿; 磯崎 直人; 新宅 博文
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], Jan. 2014, Peer-reviewed
      • 20pm3-PM018 基板上に固定した液滴アレイの電気的結合と分裂
        岡 洸佑; 横川 隆司; 小寺 秀俊; 新宅 博文
        マイクロ・ナノ工学シンポジウム, Jan. 2014
      • 2Bp16 金-ITO微小電極を用いた低電圧電気穿孔による動物細胞への物質送達デバイスの開発(バイオプロセス/センサー,計測工学/セル&ティッシュエンジニアリング,一般講演)
        袴田 和巳; 新宅 博文; 永田 雄志; 藤本 博志; 川野 聡恭; 三宅 淳
        日本生物工学会大会講演要旨集, Jan. 2012
      • ELASTomics: The Integrated Analysis of the Cell Mechanics and the Transcriptome
        SHIOMI Akifumi; KANEKO Taikopaul; NISHIKAWA Kaori; TSUCHIDA Arata; SHINTAKU Hirofumi
        Seibutsu Butsuri, 2025
      • High-throughput fluorescence lifetime imaging flow cytometry.
        Hiroshi Kanno; Kotaro Hiramatsu; Hideharu Mikami; Atsushi Nakayashiki; Shota Yamashita; Arata Nagai; Kohki Okabe; Fan Li; Fei Yin; Keita Tominaga; Omer Faruk Bicer; Ryohei Noma; Bahareh Kiani; Olga Efa; Martin Büscher; Tetsuichi Wazawa; Masahiro Sonoshita; Hirofumi Shintaku; Takeharu Nagai; Sigurd Braun; Jessica P Houston; Sherif Rashad; Kuniyasu Niizuma; Keisuke Goda
        Nature communications, 04 Sep. 2024
      • Live-organismal Transcriptomics
        Hirofumi Shintaku; Kotaro Torii; Keiko Watanabe; Alissa Gordon; Masahiro Yo; Asako Sakaue-Sawano; Atsushi Miyawaki; Kaori Nishikawa; Asuka Takeishi
        09 Jul. 2024
      • High-throughput mechanical phenotyping and transcriptomics of single cells.
        Akifumi Shiomi; Taikopaul Kaneko; Kaori Nishikawa; Arata Tsuchida; Takashi Isoshima; Mayuko Sato; Kiminori Toyooka; Kentaro Doi; Hidekazu Nishikii; Hirofumi Shintaku
        Nature Communications, 17 May 2024
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      • Opto-combinatorial indexing enables high-content transcriptomics by linking cell images and transcriptomes.
        Arata Tsuchida; Taikopaul Kaneko; Kaori Nishikawa; Mayu Kawasaki; Ryuji Yokokawa; Hirofumi Shintaku
        Lab on a chip, 16 Apr. 2024
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      • Replicating shear-mediated self-assembly of spider silk through microfluidics
        Jianming Chen; Arata Tsuchida; Ali D. Malay; Kousuke Tsuchiya; Hiroyasu Masunaga; Yui Tsuji; Mako Kuzumoto; Kenji Urayama; Hirofumi Shintaku; Keiji Numata
        Nature Communications, 15 Jan. 2024
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      • Microfluidic vascular formation model for assessing angiogenic capacities of single islets.
        Yuji Nashimoto; An Konno; Takuto Imaizumi; Kaori Nishikawa; Kosuke Ino; Takeshi Hori; Hirokazu Kaji; Hirofumi Shintaku; Masafumi Goto; Hitoshi Shiku
        Biotechnology and bioengineering, 22 Dec. 2023
      • Secretory GFP reconstitution labeling of neighboring cells interrogates cell–cell interactions in metastatic niches
        Misa Minegishi; Takahiro Kuchimaru; Kaori Nishikawa; Takayuki Isagawa; Satoshi Iwano; Kei Iida; Hiromasa Hara; Shizuka Miura; Marika Sato; Shigeaki Watanabe; Akifumi Shiomi; Yo Mabuchi; Hiroshi Hamana; Hiroyuki Kishi; Tatsuyuki Sato; Daigo Sawaki; Shigeru Sato; Yutaka Hanazono; Atsushi Suzuki; Takahide Kohro; Tetsuya Kadonosono; Tomomi Shimogori; Atsushi Miyawaki; Norihiko Takeda; Hirofumi Shintaku; Shinae Kizaka-Kondoh; Satoshi Nishimura
        Nature Communications, 05 Dec. 2023
      • The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration
        Kotaro Hirano; Masaki Tsuchiya; Akifumi Shiomi; Seiji Takabayashi; Miki Suzuki; Yudai Ishikawa; Yuya Kawano; Yutaka Takabayashi; Kaori Nishikawa; Kohjiro Nagao; Eiji Umemoto; Yasuo Kitajima; Yusuke Ono; Keiko Nonomura; Hirofumi Shintaku; Yasuo Mori; Masato Umeda; Yuji Hara
        Life Science Alliance, Nov. 2022, Peer-reviewed
      • Best practices for reporting throughput in biomedical research.
        Maik Herbig; Akihiro Isozaki; Dino Di Carlo; Jochen Guck; Nao Nitta; Robert Damoiseaux; Shogo Kamikawaji; Eigo Suyama; Hirofumi Shintaku; Angela Ruohao Wu; Itoshi Nikaido; Keisuke Goda
        Nature methods, Jun. 2022
      • Extreme deformability of insect cell membranes is governed by phospholipid scrambling.
        Akifumi Shiomi; Kohjiro Nagao; Nobuhiro Yokota; Masaki Tsuchiya; Utako Kato; Naoto Juni; Yuji Hara; Masayuki X Mori; Yasuo Mori; Kumiko Ui-Tei; Motohide Murate; Toshihide Kobayashi; Yuri Nishino; Atsuo Miyazawa; Akihisa Yamamoto; Ryo Suzuki; Stefan Kaufmann; Motomu Tanaka; Kazuya Tatsumi; Kazuyoshi Nakabe; Hirofumi Shintaku; Semen Yesylevsky; Mikhail Bogdanov; Masato Umeda
        Cell reports, 08 Jun. 2021
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      • NanoSINC-seq dissects the isoform diversity in subcellular compartments of single cells.
        Yusuke Oguchi; Yuka Ozaki; Mahmoud N Abdelmoez; Hirofumi Shintaku
        Science advances, Apr. 2021
      • Targeted permeabilization of the cell wall and extraction of charged molecules from single cells in intact plant clusters using a focused electric field.
        Sangamithirai Subramanian Parimalam; Mahmoud Nady Abdelmoez; Arata Tsuchida; Naoyuki Sotta; Mayuki Tanaka; Takashi Kuromori; Toru Fujiwara; Masami Yokota Hirai; Ryuji Yokokawa; Yusuke Oguchi; Hirofumi Shintaku
        The Analyst, 07 Mar. 2021
      • Development of a sequencing system for spatial decoding of DNA barcode molecules at single-molecule resolution.
        Yusuke Oguchi; Hirofumi Shintaku; Sotaro Uemura
        Communications biology, 18 Dec. 2020
      • Distinct Kinetics in Electrophoretic Extraction of Cytoplasmic RNA from Single Cells.
        Mahmoud N Abdelmoez; Yusuke Oguchi; Yuka Ozaki; Ryuji Yokokawa; Hidetoshi Kotera; Hirofumi Shintaku
        Analytical chemistry, 07 Jan. 2020, Peer-reviewed
      • Different motilities of microtubules driven by kinesin-1 and kinesin-14 motors patterned on nanopillars.
        Taikopaul Kaneko; Ken'ya Furuta; Kazuhiro Oiwa; Hirofumi Shintaku; Hidetoshi Kotera; Ryuji Yokokawa
        Science advances, Jan. 2020, Peer-reviewed
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      • Spatial Patterning of Kinesin-1 and Dynein Motor Proteins in an In Vitro Assay using Aqueous Two-Phase Systems (ATPS).
        Tamanna Ishrat Farhana; Tomohiro Nakagawa; Shumpei Ohara; Hirofumi Shintaku; Hidetoshi Kotera; Ryuji Yokokawa
        Langmuir : the ACS journal of surfaces and colloids, 08 Oct. 2019, Peer-reviewed
      • Transport of microtubules according to the number and spacing of kinesin motors on gold nano-pillars.
        Taikopaul Kaneko; Suguru Ando; Ken'ya Furuta; Kazuhiro Oiwa; Hirofumi Shintaku; Hidetoshi Kotera; Ryuji Yokokawa
        Nanoscale, 28 May 2019, Peer-reviewed
      • Simultaneous Observation of Kinesin-Driven Microtubule Motility and Binding of Adenosine Triphosphate Using Linear Zero-Mode Waveguides.
        Kazuya Fujimoto; Yuki Morita; Ryota Iino; Michio Tomishige; Hirofumi Shintaku; Hidetoshi Kotera; Ryuji Yokokawa
        ACS nano, 26 Dec. 2018, Peer-reviewed
      • Intelligent Image-Activated Cell Sorting.
        Nao Nitta; Takeaki Sugimura; Akihiro Isozaki; Hideharu Mikami; Kei Hiraki; Shinya Sakuma; Takanori Iino; Fumihito Arai; Taichiro Endo; Yasuhiro Fujiwaki; Hideya Fukuzawa; Misa Hase; Takeshi Hayakawa; Kotaro Hiramatsu; Yu Hoshino; Mary Inaba; Takuro Ito; Hiroshi Karakawa; Yusuke Kasai; Kenichi Koizumi; SangWook Lee; Cheng Lei; Ming Li; Takanori Maeno; Satoshi Matsusaka; Daichi Murakami; Atsuhiro Nakagawa; Yusuke Oguchi; Minoru Oikawa; Tadataka Ota; Kiyotaka Shiba; Hirofumi Shintaku; Yoshitaka Shirasaki; Kanako Suga; Yuta Suzuki; Nobutake Suzuki; Yo Tanaka; Hiroshi Tezuka; Chihana Toyokawa; Yaxiaer Yalikun; Makoto Yamada; Mai Yamagishi; Takashi Yamano; Atsushi Yasumoto; Yutaka Yatomi; Masayuki Yazawa; Dino Di Carlo; Yoichiroh Hosokawa; Sotaro Uemura; Yasuyuki Ozeki; Keisuke Goda
        Cell, 20 Sep. 2018, Peer-reviewed
      • SINC-seq: correlation of transient gene expressions between nucleus and cytoplasm reflects single-cell physiology.
        Mahmoud N Abdelmoez; Kei Iida; Yusuke Oguchi; Hidekazu Nishikii; Ryuji Yokokawa; Hidetoshi Kotera; Sotaro Uemura; Juan G Santiago; Hirofumi Shintaku
        Genome biology, 06 Jun. 2018, Peer-reviewed
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      • Efficient Production of On-Target Reads for Small RNA Sequencing of Single Cells Using Modified Adapters
        Khnouf, R.; Shore, S.; Han, C.M.; Henderson, J.M.; Munro, S.A.; McCaffrey, A.P.; Shintaku, H.; Santiago, J.G.
        Analytical Chemistry, 2018, Peer-reviewed
      • Electrical Lysis and RNA Extraction from Single Cells Fixed by Dithiobis(succinimidyl propionate)
        Subramanian Parimalam, S.; Oguchi, Y.; Abdelmoez, M.N.; Tsuchida, A.; Ozaki, Y.; Yokokawa, R.; Kotera, H.; Shintaku, H.
        Analytical Chemistry, 2018, Peer-reviewed
      • SINC-seq: Correlation of transient gene expressions between nucleus and cytoplasm reflects single-cell physiology
        Abdelmoez, M.N.; Iida, K.; Oguchi, Y.; Nishikii, H.; Yokokawa, R.; Kotera, H.; Uemura, S.; Santiago, J.G.; Shintaku, H.
        Genome Biology, 2018, Peer-reviewed
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      • Control of molecular shuttles by designing electrical and mechanical properties of microtubules
        Isozaki Naoto; Shintaku Hirofumi; Kotera Hidetoshi; Hawkins Taviare L; Ross Jennifer L; Yokokawa Ryuji
        SCIENCE ROBOTICS, 27 Sep. 2017, Peer-reviewed
      • Design and fabrication of Linear-shaped Zero Mode Waveguides for single molecule observation of kinesin and fluorescent ATP
        Fujimoto, K.; Morita, Y.; Iino, R.; Tomishige, M.; Shintaku, H.; Kotera, H.; Yokokawa, R.
        IEEJ Transactions on Sensors and Micromachines, 2017, Peer-reviewed
      • Microtubule density and landing rate as parameters to analyze tau protein in the MT-kinesin “gliding” assay
        Subramaniyan Parimalam, S.; Tarhan, M.C.; Karsten, S.L.; Fujita, H.; Shintaku, H.; Kotera, H.; Yokokawa, R.
        Sensors and Actuators, B: Chemical, 2017, Peer-reviewed
      • Pneumatically-driven microfluidic device for evaluating active transport by kinesin motor protein
        Fujimoto, K.; Shintaku, H.; Kotera, H.; Yokokawa, R.
        IEEJ Transactions on Sensors and Micromachines, 2016, Peer-reviewed
      • Velocity control of microtubules with high spatial resolution on an au-coated surface with an SU-8 thermal isolation layer
        Nakahara, T.; Shintaku, H.; Kotera, H.; Yokokawa, R.
        IEEJ Transactions on Sensors and Micromachines, 2016, Peer-reviewed
      • On-chip microtubule gliding assay for parallel measurement of tau protein species
        Subramaniyan Parimalam, S.; Tarhan, M.C.; Karsten, S.L.; Fujita, H.; Shintaku, H.; Kotera, H.; Yokokawa, R.
        Lab on a Chip, 2016, Peer-reviewed
      • In situ velocity control of gliding microtubules with temperature monitoring by fluorescence excitation on a patterned gold thin film
        Nakahara, T.; Ikuta, J.; Shintaku, H.; Kotera, H.; Yokokawa, R.
        Materials Research Express, 2015, Peer-reviewed
      • Control of microtubule trajectory within an electric field by altering surface charge density
        Isozaki, N.; Ando, S.; Nakahara, T.; Shintaku, H.; Kotera, H.; Meyhofer, E.; Yokokawa, R.
        Scientific Reports, 2015, Peer-reviewed
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      • Linearisation of λdNA molecules by instantaneous variation of the trapping electrode voltage inside a micro-channel
        Hanasaki, I.; Yukimoto, N.; Uehara, S.; Shintaku, H.; Kawano, S.
        Journal of Physics D: Applied Physics, 2015, Peer-reviewed
      • Dynamic formation of a microchannel array enabling kinesin-driven microtubule transport between separate compartments on a chip
        Fujimoto, K.; Nagai, M.; Shintaku, H.; Kotera, H.; Yokokawa, R.
        Lab on a Chip, 2015, Peer-reviewed
      • Isotachophoresis for fractionation and recovery of cytoplasmic RNA and nucleus from single cells
        Kuriyama, K.; Shintaku, H.; Santiago, J.G.
        Electrophoresis, 2015, Peer-reviewed
      • Increasing Hybridization Rate and Sensitivity of Bead-Based Assays Using Isotachophoresis
        Shintaku Hirofumi; Palko James W.; Sanders Glenn M.; Santiago Juan G.
        Angewandte Chemie, 10 Oct. 2014
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      • Fabrication of a perfusable glass microfluidic channel for microtubule manipulation using an electric field
        Nakahara, T.; Isozaki, N.; Ando, S.; Kamisetty, N.K.; Shintaku, H.; Kotera, H.; Yokokawa, R.
        IEEJ Transactions on Sensors and Micromachines, 2014, Peer-reviewed
      • Measurement of local electric field in microdevices for low-voltage electroporation of adherent cells
        Shintaku, H.; Hakamada, K.; Fujimoto, H.; Nagata, T.; Miyake, J.; Kawano, S.
        Microsystem Technologies, 2014, Peer-reviewed
      • On-chip separation and analysis of RNA and DNA from single cells
        Shintaku, H.; Nishikii, H.; Marshall, L.A.; Kotera, H.; Santiago, J.G.
        Analytical Chemistry, 2014, Peer-reviewed
      • Tug-of-war of microtubule filaments at the boundary of a kinesin-and dynein-patterned surface
        Ikuta, J.; Kamisetty, N.K.; Shintaku, H.; Kotera, H.; Kon, T.; Yokokawa, R.
        Scientific Reports, 2014, Peer-reviewed
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      • Increasing hybridization rate and sensitivity of bead-based assays using isotachophoresis
        Shintaku, H.; Palko, J.W.; Sanders, G.M.; Santiago, J.G.
        Angewandte Chemie - International Edition, 2014, Peer-reviewed
      • Wide-range frequency selectivity in an acoustic sensor fabricated using a microbeam array with non-uniform thickness
        Hirofumi Shintaku; Takayuki Kobayashi; Kazuki Zusho; Hidetoshi Kotera; Satoyuki Kawano
        JOURNAL OF MICROMECHANICS AND MICROENGINEERING, Nov. 2013, Peer-reviewed
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      • Experimental and analytical study approach of artificial basilar membrane prototype (ABMP)
        Harto Tanujaya; Hirofumi Shintaku; Dai Kitagawa; Adianto; Susilodinata; Satoyuki Kawano
        Journal of Engineering and Technological Sciences, 2013, Peer-reviewed
      • Electrically evoked auditory brainstem response by using bionic auditory membrane in guinea Pigs*
        Hirofumi Shintaku; Takatoshi Inaoka; Takayuki Nakagawa; Satoyuki Kawano; Juichi Ito
        Journal of Biomechanical Science and Engineering, 2013, Peer-reviewed
      • A hardware model of the auditory periphery to transduce acoustic signals into neural activity
        Tateno, T.; Nishikawa, J.; Tsuchioka, N.; Shintaku, H.; Kawano, S.
        Frontiers in Neuroengineering, 2013, Peer-reviewed
      • Development of a microfabricated device for low-voltage electropermeabilization of adherent cells
        Hakamada, K.; Shintaku, H.; Nagata, T.; Fujimoto, H.; Kawano, S.; Miyake, J.
        Journal of Bioscience and Bioengineering, 2013, Peer-reviewed
      • Tracking single-particle dynamics via combined optical and electrical sensing.
        Naoya Yukimoto; Makusu Tsutsui; Yuhui He; Hirofumi Shintaku; Shoji Tanaka; Satoyuki Kawano; Tomoji Kawai; Masateru Taniguchi
        Scientific reports, 2013, Peer-reviewed
      • Development of micro-vibrating flow pumps using MEMS technologies
        Osman Omran Osman; Hirofumi Shintaku; Satoyuki Kawano
        MICROFLUIDICS AND NANOFLUIDICS, Nov. 2012, Peer-reviewed
      • Electrokinetic Flow Dynamics of Weakly Aggregated lambda DNA Confined in Nanochannels
        Satoshi Uehara; Hirofumi Shintaku; Satoyuki Kawano
        JOURNAL OF FLUIDS ENGINEERING-TRANSACTIONS OF THE ASME, Dec. 2011, Peer-reviewed
      • Piezoelectric materials mimic the function of the cochlear sensory epithelium.
        Takatoshi Inaoka; Hirofumi Shintaku; Takayuki Nakagawa; Satoyuki Kawano; Hideaki Ogita; Tatsunori Sakamoto; Shinji Hamanishi; Hiroshi Wada; Juichi Ito
        Proceedings of the National Academy of Sciences of the United States of America, 08 Nov. 2011, Peer-reviewed
      • Oxygenation to Bovine Blood in Artificial Heart and Lung Using Vibrating, Flow Pump
        Hirofumi Shintaku; Tsubasa Yonemura; Kazuaki Tsuru; Takashi Isoyama; Tomoyuki Yambe; Satoyuki Kawano
        Experiment and Numerical Analysis Based on Non-Newtonian Model Journal of Fluid Science and Technology, Jun. 2010, Peer-reviewed
      • Development of coarse-graining DNA models for single-nucleotide resolution analysis
        Kentaro Doi; Tomoaki Haga; Hirofumi Shintaku; Satoyuki Kawano
        PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, Jun. 2010, Peer-reviewed
      • Development of piezoelectric acoustic sensor with frequency selectivity for artificial cochlea
        Hirofumi Shintaku; Takayuki Nakagawa; Dai Kitagawa; Harto Tanujaya; Satoyuki Kawano; Juichi Ito
        SENSORS AND ACTUATORS A-PHYSICAL, Mar. 2010, Peer-reviewed
      • Culturing neurons on MEMS fabricated P(VDF-TrFE) films for implantable artificial cochlea
        Hirofumi Shintaku; Takashi Tateno; Nobuyoshi Tsuchioka; Harto Tanujaya; Takayuki Nakagawa; Juichi Ito; Satoyuki Kawano
        Journal of Biomechanical Science and Engineering, 2010, Peer-reviewed
      • Structural and Tensile Properties of Self-Assembled DNA Network on Mica Surface
        Itsuo Hanasaki; Hirofumi Shintaku; Satoshi Matsunami; Satoyuki Kawano
        CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES, Jun. 2009, Peer-reviewed
      • Measurements of Electric Field and Electrokinetic Phenomena Using Two Kinds of Tracer Particles with Different Mobilities
        SHINTAKU Hirofumi; AZUMA Shuji; KAWANO Satoyuki
        JFST, 2009
      • Droplet Transportation on Vertical Parallel Electrodes Using Electrowetting and Interfacial Oscillation
        SHINTAKU Hirofumi; TATARA Yukio; KAWANO Satoyuki
        JFST, 2009
      • Measurements of electric field and electrokinetic phenomena using two kinds of tracer particles with different mobilities
        Hirofumi Shintaku; Shuji Azuma; Satoyuki Kawano
        Nihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B, 2009, Peer-reviewed
      • 移動度の異なるトレーサ粒子を用いた電場と界面動電現象の計測
        新宅博文; 東修士; 川野聡恭
        2009, Peer-reviewed
      • Effects of fluid dynamic stress on fracturing of cell-aggregated tissue during purification for islets of Langerhans transplantation
        H. Shintaku; T. Okitsu; S. Kawano; S. Matsumoto; T. Suzuki; I. Kanno; H. Kotera
        JOURNAL OF PHYSICS D-APPLIED PHYSICS, Jun. 2008, Peer-reviewed
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      • Microbubble formations in MEMS-fabricated rectangular channels: A high-speed observation
        Hirofumi Shintaku; Shosaku Imamura; Satoyuki Kawano
        EXPERIMENTAL THERMAL AND FLUID SCIENCE, Apr. 2008, Peer-reviewed
      • Oxygenation to Bovine Blood in Artificial Heart and Lung Using Vibrating Flow Pump
        SHINTAKU Hirofumi; YONEMURA Tsubasa; ISOYAMA Takashi; YAMBE Tomoyuki; KAWANO Satoyuki
        TRANSACTIONS OF THE JAPAN SOCIETY OF MECHANICAL ENGINEERS Series B, 2008
      • Droplet Transportation on Vertical Parallel Electrodes Using Electrowetting and Interfacial Oscillation
        Hirofumi Shintaku; Yukio Tatara; Satoyuki Kawano
        Nihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B, 2008
      • Improving the performance of a traveling wave micropump for fluid transport in Micro Total Analysis Systems
        Takaaki Suzuki; Isaku Kanno; Hidetoshi Hata; Hirofumi Shintaku; Satoyuki Kawano; Hidetoshi Kotera
        COMPLEX MEDICAL ENGINEERING, 2007, Peer-reviewed
      • Development of Valveless Micropump Piezoelectrically Driven by Traveling Wave(the 14th MAGDA Conference)
        SUZUKI Takaaki; HATA Hidetoshi; SHINTAKU Hirofumi; KANNO Isaku; KOTERA Hidetoshi; Takaaki SUZUKI; Hidetoshi HATA; Hirofumi SHINTAKU; Isaku KANNO; Hidetoshi KOTERA
        Journal of the Japan Society of Applied Electromagnetics and Mechanics, 10 Dec. 2005, Peer-reviewed
      • Development of Valveless Micropump Piezoelectrically Driven by Traveling Wave
        T. Suzuki; H. Hata; H. Shintaku; I. Kanno; H. Kotera
        Journal of the Japan Society of Applied Electromagnetics, vol. 13, pp. 310-315, 2005, Peer-reviewed
      • Development of atomization method in microchannel and its basic characteristics
        Hirofumi Shintaku; Satoyuki Kawano; Takaaki Suzuki; Isaku Kanno; Hidetoshi Kotera
        Nihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B, 2005
      • Characteristics of liquids mixing and mass transfer in passivemixer for μTAS
        Hirofumi Shintaku; Satoyuki Kawano; Isaku Kanno; Hidetoshi Kotera
        Nihon Kikai Gakkai Ronbunshu, B Hen/Transactions of the Japan Society of Mechanical Engineers, Part B, 2005

      Misc.

      • Detection of mutations in the binding domain of tau protein by kinesin-microtubule gliding assay
        S. P. Subramaniyan; M. C. Tarhan; S. L. Karsten; H. Fujita; H. Shintaku; H. Kotera; R. Yokokawa
        Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), 01 Jan. 2014
      • A Low Temperature Bonding Technique for Microfluidic Chip Fabrication Using Soft-Cure Su-8 Sheet,
        H. Shintaku; Y. Hirabayashi; T. Okitsu; S. Kawano; T. Suzuki; I. Kanno; H. Kotera
        Proceedings of Tenth International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2006), pp. 681-683, Tokyo, Japan, Nov,5-9,, 01 Jan. 2006
      • Dielectrophoretic Electrode Array for Optimum Cell Flow in Pressure Driven Flow
        H. Shintaku; S. Kawano; T. Suzuki; I. Kanno; H. Kotera
        Proceedings of Ninth International Conference on Miniaturized Systems for Chemistry and Life Massachusetts, USA, Oct,9-13,, 01 Jan. 2005
      • Visualization and Optimization for Fluid Flow of Traveling Wave Micropump Using Micropiv and Numerical Simulation,
        T. Suzuki; H. Hata; H. Shintaku; I. Kanno; S. Kawano; H. Kotera
        Ninth International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2005), pp. 1108-1110, Boston Marriott Copley Place, Boston, Massachusetts, USA,Oct,9-13,, 01 Jan. 2005
      • Manipulation of microtubles motility using electrical filed on kiensin/dynein coated surfaces
        Nagendra Kumar Kamisetty; Junya Ikuta; Hirofumi Shintaku; Hidetoshi Kotera; Ryuji Yokokawa; Ryuji Yokokawa
        17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, 01 Jan. 2013
      • Microtubule gliding at the boundary of kinesin and dynein patterned surface
        Junya Ikuta; Nagendra K. Kamisetty; Hirofumi Shintaku; Hidetoshi Kotera; Ryuji Yokokawa; Ryuji Yokokawa
        17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, 01 Jan. 2013
      • Microtubule manipulation by an electric field in a fused silica channel
        Tasuku Nakahara; Naoto Isozaki; Suguru Ando; Nagendra K. Kamisetty; Hirofumi Shintaku; Hidetoshi Kotera; Ryuji Yokokawa; Ryuji Yokokawa
        17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, 01 Jan. 2013

      Presentations

      • ナノ界面動電現象を利用した1細胞RNA動態解析
        新宅博文
        第24回日本再生医療学会総会，シンポジウム「４次元解析から明らかになる細胞の動態」, 21 Mar. 2025, Invited
      • 浸潤能の異なる乳がん細胞が示す力学的拘束に対する応答の多様性
        近藤 桂祐; 野﨑 佳司; 峯岸 美紗; 新宅 博文
        日本機械学会関西支部 2024年度関西学生会卒業研究発表講演会, 18 Mar. 2025
      • 時空間トランスクリプトミクスのための極微量流体制御装置の開発
        村井 潤一; 金子 泰洸ポール; 峯岸 美紗; 新宅 博文
        日本機械学会関西支部 2024年度関西学生会卒業研究発表講演会, 18 Mar. 2025
      • Nano-electrokinetic transcriptomics empowers the phenotyping of single cells
        Hirofumi Shintaku
        International;KNU G-LAMP;Symposium on Transcriptomics, 20 Feb. 2025, Invited
      • Molecular mechanisms behind the dormant state of cancer cells in a mechanical microenvironment
        Keiji Nozaki; Misa Minegishi; Mahmoud N. Abdelmoez; Kaori Nishikawa; Hirofumi Shintaku
        Global Young Scientist Summit 2025, 06 Jan. 2025
      • Nano-electrokinetic transcriptomics to link gene expressions to single-cell behaviors
        Hirofumi Shintaku
        Human Cell Atlas Asia General Meeting, 03 Dec. 2024, Invited
      • 力学的制約による乳がん細胞の増殖状態から休眠状態へ至るダイナミクスの分子機構
        峯岸 美紗; 野﨑 佳司; アブデルモエズ マハムド; 西川 香里; 新宅 博文
        第15回マイクロ・ナノ工学シンポジウム, 27 Nov. 2024, Invited
      • 細胞の力学特性と遺伝子発現の統合解析法
        塩見 晃史; 金子 泰洸ポール; 西川 香里; 土田 新; Dino Di Carlo; 新宅 博文
        第15回マイクロ・ナノ工学シンポジウム, 27 Nov. 2024
      • 分泌・再構成型蛍光標識技術を用いたがん近傍組織細胞の詳細解析
        峯岸 美紗; 新宅 博文; 口丸 高弘
        第11回JCRベーシックリサーチカンファレンス, 15 Nov. 2024, Invited
      • Nanoscale electrokinetics empowers mechano phenotyping of single cells
        Hirofumi Shintaku
        Lab-on-a-Chip, Microfluidics, & Organ-on-a-Chip Asia 2024, 07 Nov. 2024, Invited
      • Opto-combinatorial indexing reveals the distinct transcriptomic responses associated with paclitaxel-induced multinuclear formation by linking cellular images and transcriptomes
        Arata Tsuchida; Taikopaul Kaneko; Kaori Nishikawa; Mayu Kawasaki; Hirofumi Shintaku
        The 30th East Asia Joint Symposium, 29 Oct. 2024, Invited
      • Nanoelectrokinetics dissects dynamic functions of single cells
        Hirofumi Shintaku
        the Hong Kong University of Science and Technology, 01 Nov. 2024, Invited
      • Expanding the capacity of opto-combinatorial indexing for multimodal single-cell analysis
        Arata Tsuchida; Taikopaul Kaneko; Kaori Nishikawa; Mayu Kawasaki; Hirofumi Shintaku
        The 28th International Conference on Miniaturized Systems for Chemistry and Life Sciences -Micro-Total Analysis Systems (µTAS 2024), 13 Oct. 2024
      • Tools for analyzing cancer cell interactions with their surrounding microenvironments
        Misa Minegishi; Keiji Nozaki; Kaori Nishikawa; Takahiro Kuchimaru; Hirofumi Shintaku
        The 19th International Symposium of the Institute Network for Biomedical Sciences, 10 Oct. 2024, Invited
      • ナノ界面動電現象を活用した1細胞機能とmRNA発現の接続
        新宅 博文
        第44回キャピラリー電気泳動シンポジウム (SCE2024), 10 Oct. 2024, Invited
      • Integration of mechanical phenotyping and transcriptomics by ELASTomics and MECHANOmics
        Akifumi Shiomi; Taikopaul Kaneko; Kaori Nishikawa; Dino Di Carlo; Hirofumi Shintaku
        The 52nd Naito Conference, 01 Oct. 2024
      • マイクロハイドロゲルの力学的制約により休眠誘導されたがん細胞の大規模解析
        野﨑 佳司; 峯岸 美紗; 西川 香里; 新宅 博文
        日本機械学会 2024年度年次大会, 10 Sep. 2024
      • Mechanical phenotyping of single cells via nano-electrokinetics
        Hirofumi Shintaku
        ASM Chapter Seminar, University of Central Florida, 26 Aug. 2024, Invited
      • Linking single-cell behaviors to transcriptomics via nano-electrokinetics
        Hirofumi Shintaku
        RNA Club, University of Florida, 22 Aug. 2024, Invited
      • Linking cellular behaviors to transcriptomics at single-cell resolution
        Hirofumi Shintaku
        The 19th International Workshop on Biomaterials in Interface Science, Interface Summer Seminar, 05 Aug. 2024, Invited
      • Microfluidic valve technology produces microchannel array to evaluate kinesin-driven molecular transport
        K. Fujimoto; H. Shintaku; H. Kotera; R. Yokokawa
        18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014, 2014, Chemical and Biological Microsystems Society
      • オンチップ血管網での剪断応力知覚による血管新生の評価
        寺岡 佑佳子; 西山 功一; 三浦 岳; 横川 隆司; 中山 雅宗; 梨本 裕司; 中益 朗子; 花田 三四郎; 有馬 勇一郎; 鳥澤 勇介; 新宅 博文; 小寺 秀俊
        バイオエンジニアリング講演会, Jan. 2018, 一般社団法人 日本機械学会
      • 金ナノピラーとSAMを用いた等間隔でのダイニンの配置
        大庭 將太郎; 金子 泰洸ポール; 新宅 博文; 小寺 秀俊; 横川 隆司
        バイオエンジニアリング講演会, Jan. 2018, 一般社団法人 日本機械学会
      • Microtubule Sorting by Persistence Length and Surface Charge Density of Microtubules
        Naoto Isozaki; Hirofumi Shintaku; Hidetoshi Kotera; Taviare L. Hawkins; Jennifer L. Ross; Ryuji Yokokawa
        BIOPHYSICAL JOURNAL, Feb. 2017, CELL PRESS
      • Sorting of molecular shuttles by designing electrical and mechanical properties of microtubules
        Naoto Isozaki; Hirofumi Shintaku; Hidetoshi Kotera; Taviare L. Hawkins; Jennifer L. Ross; Ryuji Yokokawa
        Feb. 2017, Cold Spring Harbor Laboratory
      • A METHOD FOR CONTROLLING MICROTUBULE VELOCITY USING LIGHT IRRADIANCE ON A PATTERNED GOLD SURFACE
        Tasuku Nakahara; Hirofumi Shintaku; Hidetoshi Kotera; Ryuji Yokokawa
        2015 28TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2015), 2015, IEEE
      • VASCULAR NETWORK FORMATION FOR A LONG-TERM SPHEROID CULTURE BY CO-CULTURING ENDOTHELIAL CELLS AND FIBROBLASTS
        Tomoya Hayashi; Hisako Takigawa-Imamura; Koichi Nishiyama; Hirofumi Shintaku; Hidetoshi Kotera; Takashi Miura; Ryuji Yokokawa
        2015 28TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2015), 2015, IEEE
      • MICROTUBULE SORTIING WITHIN A GIVEN ELECTRIC FIELD BY DESIGNING FLEXURAL RIGIDITY
        Naoto Isozaki; Hirofumi Shintaku; Hidetoshi Kotera; Edgar Meyhoefer; Ryuji Yokokawa
        2015 28TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2015), 2015, IEEE
      • 微小管の運動方向制御に向けた電気泳動移動度及びキネシン間距離の制御
        安藤 駿; 磯崎 直人; 新宅 博文
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], Jan. 2014, Institute of Electrical Engineers of Japan
      • 動的に形成されるマイクロチャネルによる微小管グライディング制御
        藤本 和也; 新宅 博文; 小寺 秀俊
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], Jan. 2014, Institute of Electrical Engineers of Japan
      • Combined analysis of static and dynamic cell-mechanics with unbiased transcriptomics for thousands of single cells
        Akifumi Shiomi; Taikopaul Kaneko; Kaori Nishikawa; Dino Di Carlo; Hirofumi Shintaku
        the 21st IUPAB and 62nd BSJ Joint Congress 2024, 24 Jun. 2024
      • A high-throughput analysis of cancer-cell dormancy under mechanical confinement with micro-hydrogel beads
        Misa Minegishi; Keiji Nozaki; Kaori Nishikawa; Hirofumi Shintaku
        21st IUPAB and 62nd BSJ Joint Congress 2024 (IUPAB 2024), 25 Jun. 2024, Invited
      • Profiling proliferation phenotype of cancer cells under micro-mechanical confinement with cytometry and sequencing
        Keiji Nozaki; Misa Minegishi; Kaori Nishikawa; Hirofumi Shintaku
        International Symposium on Mechanical Control of Biological Self-organization, 17 Jun. 2024
      • Combined analysis of static and dynamic cell mechanics with unbiased transcriptomics for thousands of single cells
        Akifumi Shiomi; Taikopaul Kaneko; Kaori Nishikawa; Hirofumi Shintaku
        International Symposium on Mechanical Control of Biological Self-organization, 17 Jun. 2024
      • Profiling transcriptomic responses to chemical perturbation by opto-combinatorial indexing
        Arata Tsuchida; Taikopaul Kaneko; Kaori Nishikawa; Mayu Kawasaki; Hirofumi Shintaku
        Serendipity Symposium 2024, 10 Mar. 2024
      • A large-scale analysis of dormant cancer cells under mechanical confinement by micro-hydrogel
        Keiji Nozaki; Misa Minegishi; Kaori Nishikawa; Hirofumi Shintaku
        Serendipity Symposium 2024, 10 Mar. 2024
      • Optically color-coded beads for multiplexed co-profiling of image-based phenotype and transcriptome
        Taikopaul Kaneko; Arata Tsuchida; Mayu Kawasaki; Kaori Nishikawa; Hirofumi Shintaku
        Serendipity Symposium 2024, 10 Mar. 2024
      • Isotachophoresis-based RNA extraction from fixed single cells
        Subramanian Parimalam Sangamithirai; Yusuke Oguchi; Mahmoud N. Abdelmoez; Arata Tsuchida; Yuka Ozaki; Ryuji Yokokawa; Hidetoshi Kotera; Hirofumi Shintaku
        The Proceedings of the Symposium on Micro-Nano Science and Technology, 2018, Japan Society of Mechanical Engineers
      • Sprouting from on-chip vascular networks by a pressure-driven flow
        Masamune Nakayama; Yuji Nashimoto; Itsuki Kunita; Akiko Nakamasu; Yu Suke Torisawa; Hirofumi Shintaku; Hidetoshi Kotera; Koichi Nishiyama; Takashi Miura; Ryuji Yokokawa
        20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016, 2016
      • Micro- and nanoscale electrokinetics for single-cell multimodal analyses
        Hirofumi Shintaku
        µTAStic, 02 Feb. 2024, Invited
      • Nanopore electroporation enables profiling cell surface tension and gene expression at single-cell resolution
        Hirofumi Shintaku; Akifumi Shiomi; Taikopaul Kaneko; Kaori, Nishikawa
        The 61th Annual Meeting of the Biophysical Society of Japan, 15 Nov. 2023, Invited
      • Micro- and nanoscale electroporation for single-cell multiomics
        Hirofumi Shintaku
        The 29th EAJS -East Asia Joint Symposium, 25 Oct. 2023, Invited
      • Microgels for a large-scale screening and longitudinal observations of cancer cell dormancy
        Misa Minegishi; Hirofumi Shintaku
        The 27th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2023), Oct. 2023
      • ELASTomics: High-throughput mechanical phenotyping and transcriptomics of single cells
        Akifumi Shiomi; Taikopaul Kaneko; Kaori Nishikawa; Hirofumi Shintaku
        The 27th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2023, Oct. 2023
      • Micro- and nanoscale electroporation for single-cell multiomics: live organismal transcriptomics
        Kotaro Torii; Keiko Watanabe; Kaori Nishikawa; Asuka Takeishi; Hirofumi Shintaku
        Physics and Chemistry of Microfluidics, Gordon Research Conference, Jul. 2023
      • ELASTomics: Combined analysis of mechanical phenotype of cellular surface and transcriptome at single-cell resolution
        Akifumi Shiomi; Taikopaul Kaneko; Kaori Nishikawa; Hirofumi Shintaku
        Physics and Chemistry of Microfluidics Gordon Research Seminar, Jul. 2023
      • Opto-combinatorial indexing enables high content transcriptomics by linking cell images and the whole transcriptome
        Arata Tsuchida; Taikopaul Kaneko; Mayu Kawasaki; Kaori Nishikawa; Hirofumi Shintaku
        Physics and Chemistry of Microfluidics, Gordon Research Conference, Jul. 2023
      • 圧力駆動流によるオンチップ血管新生の促進—Angiogenic Sprouting from On-Chip Vascular Networks by a Pressure-Driven Flow
        中山 雅宗; 梨本 裕司; 國田 樹; 中益 朗子; 鳥澤 勇介; 新宅 博文; 小寺 秀俊; 西山 功一; 三浦 岳; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], Oct. 2016, Institute of Electrical Engineers of Japan
      • Detection of mutations in the binding domain of tau protein by kinesin-microtubule gliding assay
        S. P. Subramaniyan; M. C. Tarhan; S. L. Karsten; H. Fujita; H. Shintaku; H. Kotera; R. Yokokawa
        Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), 01 Jan. 2014
      • Manipulation of microtubles motility using electrical filed on kiensin/dynein coated surfaces
        Nagendra Kumar Kamisetty; Junya Ikuta; Hirofumi Shintaku; Hidetoshi Kotera; Ryuji Yokokawa; Ryuji Yokokawa
        17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, 01 Jan. 2013
      • Microtubule gliding at the boundary of kinesin and dynein patterned surface
        Junya Ikuta; Nagendra K. Kamisetty; Hirofumi Shintaku; Hidetoshi Kotera; Ryuji Yokokawa; Ryuji Yokokawa
        17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, 01 Jan. 2013
      • Microtubule manipulation by an electric field in a fused silica channel
        Tasuku Nakahara; Naoto Isozaki; Suguru Ando; Nagendra K. Kamisetty; Hirofumi Shintaku; Hidetoshi Kotera; Ryuji Yokokawa; Ryuji Yokokawa
        17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, 01 Jan. 2013
      • A Low Temperature Bonding Technique for Microfluidic Chip Fabrication Using Soft-Cure Su-8 Sheet,
        H. Shintaku; Y. Hirabayashi; T. Okitsu; S. Kawano; T. Suzuki; I. Kanno; H. Kotera
        Proceedings of Tenth International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2006), pp. 681-683, Tokyo, Japan, Nov,5-9,, 01 Jan. 2006
      • Dielectrophoretic Electrode Array for Optimum Cell Flow in Pressure Driven Flow
        H. Shintaku; S. Kawano; T. Suzuki; I. Kanno; H. Kotera
        Proceedings of Ninth International Conference on Miniaturized Systems for Chemistry and Life Massachusetts, USA, Oct,9-13,, 01 Jan. 2005
      • Visualization and Optimization for Fluid Flow of Traveling Wave Micropump Using Micropiv and Numerical Simulation,
        T. Suzuki; H. Hata; H. Shintaku; I. Kanno; S. Kawano; H. Kotera
        Ninth International Conference on Miniaturized Systems for Chemistry and Life Sciences (microTAS2005), pp. 1108-1110, Boston Marriott Copley Place, Boston, Massachusetts, USA,Oct,9-13,, 01 Jan. 2005
      • Development of image analysis with nanometer resolution for evaluation of the flexural rigidity and the growth rate of microtubules
        浮田 一輝; 磯崎 直人; 新宅 博文; 小寺 秀俊; Hawkins Taviare L; Ross Jennifer L; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], 31 Oct. 2017
      • Development of a nano-patterning of motor proteins by integration of Au nano-pillars and SAM
        大庭 將太郎; 金子 泰洸ポール; 新宅 博文; 小寺 秀俊; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], 31 Oct. 2017
      • Selective immobilization of different motor proteins by using Aqueous Two-Phase System(ATPS)
        中川 倫宏; 大原 駿平; 新宅 博文; 小寺 秀俊; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], 31 Oct. 2017
      • Evaluation of Angiogenesis on 3D Vasculature through Detection and Transduction of Shear Stress
        寺岡 佑佳子; 中山 雅宗; 梨本 裕司; 中益 朗子; 花田 三四郎; 有馬 勇一郎; 鳥澤 勇介; 新宅 博文; 小寺 秀俊; 西山 功一; 三浦 岳; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], 31 Oct. 2017
      • Single molecule observation of fluorescent labelled ATP in microtubule gliding motility using LZMWs
        藤本 和也; 飯野 亮太; 富重 道雄; 新宅 博文; 小寺 秀俊; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], 31 Oct. 2017
      • Evaluating collective motion of kinesins using a nano-patterning
        金子 泰洸ポール; 大庭 將太郎; 新宅 博文; 小寺 秀俊; 横川 隆司; 古田 健也; 大岩 和弘
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], 31 Oct. 2017
      • NANO-PATTERNING OF MOTOR PROTEINS TO CONTROL NUMBER OF KINESIN MOLECULES TRANSPORTING A SINGLE MICROTUBULE
        Taikopaul Kaneko; Hirofumi Shintaku; Hidetoshi Kotera; Ryuji Yokokawa
        30TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2017), 2017, IEEE
      • LINEAR ZERO MODE WAVEGUIDES FOR THE STUDY OF CHEMO-MECHANICAL COUPLING MECHANISM OF KINESIN
        Kazuya Fujimoto; Yuki Morita; Ryota Iino; Michio Tomishige; Hirofumi Shintaku; Hidetoshi Kotera; Ryuji Yokokawa
        30TH IEEE INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2017), 2017, IEEE
      • Angiogenic Sprouting from On-Chip Vascular Networks by a Pressure-Driven Flow
        中山 雅宗; 梨本 裕司; 國田 樹; 中益 朗子; 鳥澤 勇介; 新宅 博文; 小寺 秀俊; 西山 功一; 三浦 岳; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], 02 Oct. 2016
      • High-precision Microtubule Sorting by Designing Electrical Charge and Flexural Rigidity
        磯崎 直人; 新宅 博文; 小寺 秀俊; Hawkins Taviare L; Ross Jennifer L; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], 02 Oct. 2016
      • Visualization of ATP hydrolysis cycle of kinesin in LZMW
        藤本 和也; 森田 有貴; 飯野 亮太; 富重 道雄; 新宅 博文; 小寺 秀俊; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], 02 Oct. 2016
      • Selective patterning of kinesin and dynein by microchannel for multi-motor study
        尾田 文恵; 森田 充樹; 新宅 博文; 小寺 秀俊; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], 28 Oct. 2015
      • Evaluation of kinesin bead assay driven transport in dynamic microchannel and numerical analysis
        藤本 和也; 新宅 博文; 小寺 秀俊; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], 28 Oct. 2015
      • Design of Microtubule Flexural Rigidity for Controlling Microtubule Gliding Directions
        磯崎 直人; 新宅 博文; 小寺 秀俊; 横川 隆司
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], 28 Oct. 2015
      • J0540101 Purity of cytoplasmic RNA extracted from single cells via electrical lysis and isotachophoresis
        HATA Shota; YOKOKAWA Ryuji; KOTERA Hidetoshi; SHINTAKU Hirofumi
        The Proceedings of Mechanical Engineering Congress, Japan, 2015
      • Control of MT gliding in dynamically formed micro channels
        藤本 和也; 新宅 博文; 小寺 秀俊
        「センサ・マイクロマシンと応用システム」シンポジウム論文集 電気学会センサ・マイクロマシン部門 [編], 20 Oct. 2014
      • 20pm3-PM018 Electrocoalescence and breakup of droplet array on a substrate
        Oka Kosuke; Yokokawa Ryuji; Kotera Hidetoshi; Shintaku Hirofumi
        The Proceedings of the Symposium on Micro-Nano Science and Technology, 2014
      • 6AM2-D-3 Preconcentration of macromolecules for efficient on-chip cell electroporation
        Juri Yuko; Yokokawa Ryuji; Kotera Hidetoshi; Shintaku Hirofumi
        The Proceedings of the Symposium on Micro-Nano Science and Technology, 2013
      • J026023 Estimating trajectories by measuring electrophoretic mobility of MTs
        ANDO Suguru; ISOZAKI Naoto; NAKAHARA Tasuku; SHINTAKU Hirofumi; KOTERA Hidetoshi; YOKOKAWA Ryuji
        The Proceedings of Mechanical Engineering Congress, Japan, 2013
      • J026022 Visualization of Molecular Transfer to Cell Organelle in On-Chip Electroporation Using Focused Electric Field
        KAJIMOTO Takao; OKA Kosuke; SHINTAKU Hirofumi; YOKOKAWA Ryuji; KOTERA Hidetoshi
        The Proceedings of Mechanical Engineering Congress, Japan, 2013
      • J161044 Development of a micro fluidic device for visualization of mass transfer through cell membranes induced by electroporation
        KAJIMOTO Takao; OKONOGI Atsuhito; SUZUKI Takaaki; SHINTAKU Hirofumi; YOKOKAWA Ryuji; KOTERA Hidetoshi
        The Proceedings of Mechanical Engineering Congress, Japan, 2012
      • J161043 Micro-Device for Light-Induced Stimulation on Cells via Light-Responsive Proteins
        JURI Yuko; KOMAI Shoji; OKONOGI Atsuhiko; OHOKA Masataka; TATSUMI Kazuya; SHINTAKU Hirofumi; YOKOKAWA Ryuji; KOTERA Hidetoshi
        The Proceedings of Mechanical Engineering Congress, Japan, 2012
      • J161035 Observation of molecular transport and binding driven by motor proteins
        FUJIMOTO Kazuya; KITAMURA Masuto; YOKOKAWA Masatoshi; SHINTAKU Hirofumi; KOTERA Hidetoshi; YOKOKAWA Ryuji
        The Proceedings of Mechanical Engineering Congress, Japan, 2012
      • J161034 Manipulation of MTs docking to the surface modified by heterogeneous proteins
        Ikuta Junya; Kumar Kamisetty Nagendra; Shintaku Hirofumi; Kotera Hidetoshi; Yokokawa Ryuji
        The Proceedings of Mechanical Engineering Congress, Japan, 2012
      • OS3-1-6 Visualization of Translocation of Macromolecules through Cell Membrane Induced by Electroporation Using Field Focusing
        Kajimoto Takao; Shintaku Hirofumi; Yokokawa Ryuji; Kotera Hidetoshi
        The Proceedings of the Symposium on Micro-Nano Science and Technology, 2012
      • 0707 Effects of cell electroporation using focused electric field on organelle
        TECHAUMNAT Boonchai
        The Proceedings of the Fluids engineering conference, 2012
      • 2Bp16 Development of Low voltage electroporation device using Au-ITO electrode for adherent cell
        Hakamada Kazumi; Shintaku Hirofumi; Nagata Takeshi; Fujimoto Hiroshi; Kawano Satoyuki; Miyake Jun
        日本生物工学会大会講演要旨集, 2012
      • 9E-09 Development of microfluidic systems for localized chemical stimulation to neural networks
        TSUCHIOKA Nobuyoshi; SHINTAKU Hirohumi; KAWANO Satoyuki
        The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2011
      • 8E-18 Measuring responses of multielectrode bionic auditory membrane to time dependent sound
        KANBE Toshiya; SHINTAKU Hirofumi; KAWANO Satoyuki
        The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2011
      • (13)MEMS流体デバイスによる界面現象の制御と計測に関する研究(研究奨励,日本機械学会賞〔2009年度(平成21年度)審査経過報告〕)
        新宅 博文
        日本機械学会誌, 2010
      • 1509 Electrophoretic phenomena of long DNAs in confined nano spaces
        UEHARA Satoshi; SHINTAKU Hirohumi; KAWANO Satoyuki
        The Proceedings of the Fluids engineering conference, 2010
      • T0501-5-6 Effect of external electric field on self-assembled structure of poly(dA)・poly(dT) DNA
        KAKIZAKI Toshiya; AKAMATSU Shingo; DOI Kentaro; SHINTAKU Hirohumi; KAGAYA Yoichi; KAWANO Satoyuki
        The Proceedings of Mechanical Engineering Congress, Japan, 2010
      • T0501-5-5 Experimental and Theoretical Studies on Vibration Dynamics of MEMS Acoustic Sensor for Novel Artificial Cochleae
        Shintaku Hirofumi; Kawano Satoyuki
        The Proceedings of Mechanical Engineering Congress, Japan, 2010
      • T0501-5-4 Measurement and Modeling of DNA's Flow Dynamics under Confinement in a Nanochannel
        Uehara Satoshi; Shintaku Hirofumi; Kawano Satoyuki
        The Proceedings of Mechanical Engineering Congress, Japan, 2010
      • 0824 Analysis of Vibrating Amplitude and Electric Signal on MEMS Device of Artificial Cochlea
        Tanujaya Harto; Shintaku Hirofumi; Kanbe Toshiya; Nakamoto Yohei; Kawano Satoyuki; Nakagawa Takayuki; Ito Juichi
        The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2010
      • M6-3 Flow dynamics of long DNA under electric field in nanochannel (M6 Bio Sensor and System)
        Shintaku Hirofumi; Uehara Satoshi; Kawano Satoyuki
        The Proceedings of the Symposium on Micro-Nano Science and Technology, 2009
      • M6-2 In vivo investigation on stimulating performances of MEMS fabricated basilar membrane for artificial cochlea using guinea pig (M6 Bio Sensor and System)
        NAKAMOTO Yohei; SHINTAKU Hirofumi; INAOKA Takatoshi; NAKAGAWA Takayuki; ITO Juichi; KAWANO Satoyuki
        The Proceedings of the Symposium on Micro-Nano Science and Technology, 2009
      • 109 Dynamics of Contact Lines and Angles on Droplet Transportation Using Vertical Parallel Electrodes
        新宅 博文; 多田羅 晋生; 川野 聡恭
        The Proceedings of Conference of Kansai Branch, 2009
      • T0502-3-3 Nanoscale flow control of biomacromolecules using micro transparent electrode
        SHINTAKU Hirofumi; KAWANO Satoyuki
        The Proceedings of Mechanical Engineering Congress, Japan, 2009
      • T0502-3-2 Flow visualization of biomacromolecules in nanochannel
        Uehara Satoshi; Shintaku Hirofumi; Kawano Satoyuki
        The Proceedings of Mechanical Engineering Congress, Japan, 2009
      • T0502-1-4 Development of novel MEMS fabricated artificial cochlea using thin piezoelectric polymer film
        KANBE Toshiya; SHINTAKU Hirofumi; KAWANO Satoyuki
        The Proceedings of Mechanical Engineering Congress, Japan, 2009
      • T0502-1-3 Investigation on characteristics of MEMS fabricated artificial basilar membrane in guinea pig cochlea
        NAKAMOTO Yohei; SHINTAKU Hirofumi; KAWANO Satoyuki
        The Proceedings of Mechanical Engineering Congress, Japan, 2009
      • 0902 Measurement of Electrokinetic Phenomena in Microchannel with Transparent Electrodes
        SHINTAKU Hirofumi; KAWANO Satoyuki
        The Proceedings of the Fluids engineering conference, 2009
      • 637 Fluid dynamical effect on vibration of basilar membrane for artificial cochlea
        KITAGAWA Dai; SHINTAKU Hirofumi; KAWANO Satoyuki
        The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2009
      • 335 Fluid dynamical analysis on contact line and angle in droplet-based μTAS
        TATARA Yukio; SHINTAKU Hirofumi; KAWANO Satoyuki
        The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2009
      • 302 Electric measurement of biomacromolecules using electrode embedded nanochannel
        SHINTAKU Hirofumi; UEHARA Satoshi; KAWANO Satoyuki
        The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2009
      • 1010 Experimental Analysis of Electroosmotic Flow in Microchannel with Bifurcating Channel
        AZUMA Shuji; SHINTAKU Hirofumi; KAWANO Satoyuki
        The Proceedings of Conference of Kansai Branch, 2008
      • 502 Development of an artificial cochlea using piezoelectric material and its basic characteristics
        KITAGAWA Dai; SHINTAKU Hirofumi; KAWANO Satoyuki
        The Proceedings of Conference of Kansai Branch, 2008
      • 352 Characteristics of vibration and frequency selectivity of artificial basilar membrane
        KITAGAWA Dai; SHINTAKU Hirofumi; KAWANO Satoyuki
        The Proceedings of Mechanical Engineering Congress, Japan, 2008
      • 351 Vibration analysis of piezoelectric artificial basilar membrane
        NAKAMOTO Yohei; SHINTAKU Hirofumi; KAWANO Satoyuki
        The Proceedings of Mechanical Engineering Congress, Japan, 2008
      • Mathematical model for droplet transportation using interfacial oscillation and electrowetting
        TATARA Yukio; SHINTAKU Hirofumi; KAWANO Satoyuki
        微粒化シンポジウム講演論文集 = Symposium (ILASS-Japan) on Atomization, 19 Dec. 2007
      • 心停止ドナー新鮮膵島移植のための膵島分離法の開発と臨床応用
        興津 輝; 松本 慎一; 岩永 康裕; 川口 義弥; 川口 道也; 野口 洋文; 永田 英生; 新宅 博文; 小寺 秀俊; 和田 洋巳; 上本 伸二
        日本外科学会雑誌, 10 Mar. 2007
      • 1101 Effects of overlapped electric double layer and interfacial charge on ionic transport phenomena(2)
        Shintaku Hirofumi; Kawano Satoyuki
        The Proceedings of the Fluids engineering conference, 2007
      • 1101 Effects of overlapped electric double layer and interfacial charge on ionic transport phenomena(1)
        Shintaku Hirofumi; Kawano Satoyuki
        The Proceedings of the Fluids engineering conference, 2007
      • 201 Numerical Analysis of Electroosmotic Flow in Microchannel with Bifurcating Channel
        AZUMA Shuji; SHINTAKU Hirofumi; KAWANO Satoyuki
        The Proceedings of Conference of Kansai Branch, 2007
      • 213 CFD Study on Control of Oxigen Concentration in Vibrating Flow Blood Pump for Artificial Heart
        YONEMURA Tsubasa; KAWANO Satoyuki; Shintaku Hirofumi; ISOYAMA Takashi; YAMAIE Tomoyuki
        The Proceedings of Conference of Kansai Branch, 2007
      • 203 Development of Droplet Transporting Method using Electrowetting-Based Actuation
        TATARA Yukio; SHINTAKU Hirofumi; KAWANO Satoyuki
        The Proceedings of Conference of Kansai Branch, 2007
      • 204 Numerical Analysis of Liquid Flow in Microchannel with Superhydrophobic Surface
        KITAGAWA Dai; SHINTAKU Hirofumi; KAWANO Satoyuki
        The Proceedings of Conference of Kansai Branch, 2007
      • 210 Development of theoretical model for micro bubble generation in MEMS-fabricated microchannel
        IMAMURA Shosaku; SHINTAKU Hirofumi; KAWANO Satoyuki
        The Proceedings of Conference of Kansai Branch, 2007
      • 202 Numerical analysis of solute concentration control on a wall of micro-channel
        NISHIKAWA Akihisa; HANASAKI Itsuo; SHINTAKU Hirofumi; KAWANO Satoyuki
        The Proceedings of Conference of Kansai Branch, 2007
      • 1103 Development of resin-based cell separation chip using ultrasonic radiation force
        Hirabayashi Yasutoshi; Shintaku Hirofumi; Suzuki Takaaki; Kanno Isaku; Kotera Hidetoshi
        IIP, 2007
      • 1431 Effects of electric double layer and elecrokinetic potential on nano liquid flows
        SHINTAKU Hirofumi; KAWANO Satoyuki
        The Proceedings of Mechanical Engineering Congress, Japan, 2007
      • 3320 Study on cell separation method using ultrasonic radiation pressure
        Hirabayashi Yasutoshi; Shintaku Hirofumi; Suzuki Takaaki; Kanno Isaku; Kotera Hidetoshi
        The Proceedings of Mechanical Engineering Congress, Japan, 2007
      • Analysis of shear stress on the living tissue in microchannels
        SHINTAKU Hirofumi; OKITSU Teru; KAWANO Satoyuki; SUZUKI Takaaki; KANNO Isaku; KANI Kohei; HORINAKA Junichi; TAKIGAWA Toshikazu; MATSUMOTO Shinichi; KOTERA Hidetoshi
        電気学会研究会資料. BMS, バイオ・マイクロシステム研究会 = The papers of Technical Meeting on Bio Micro Systems, IEE Japan, 15 May 2006
      • 820 Fracture of living cells in the cell separation process(2)
        Shintaku Hirofumi; Kawano Satoyuki; Suzuki Takaaki; Kanno Isaku; Kotera Hidetoshi
        The Proceedings of the Fluids engineering conference, 2006
      • 820 Fracture of living cells in the cell separation process(1)
        Shintaku Hirofumi; Kawano Satoyuki; Suzuki Takaaki; Kanno Isaku; Kotera Hidetoshi
        The Proceedings of the Fluids engineering conference, 2006
      • 806 Atomization Method of Polymer Gel Using Microchannel(2)
        KUWABARA Takeo; SHINTAKU Hirofumi; KAWANO Satoyuki; SUZUKI Takaaki; KANNO Isaku; KOTERA Hidetoshi
        The Proceedings of the Fluids engineering conference, 2006
      • 806 Atomization Method of Polymer Gel Using Microchannel(1)
        KUWABARA Takeo; SHINTAKU Hirofumi; KAWANO Satoyuki; SUZUKI Takaaki; KANNO Isaku; KOTERA Hidetoshi
        The Proceedings of the Fluids engineering conference, 2006
      • 5515 Development of Micro Gel Beads Generation for Cell Transplants
        Kuwabara Takeo; Shintaku Hirofumi; Suzuki Takaaki; Kanno Isaku; Kotera Hidetoshi
        The Proceedings of Mechanical Engineering Congress, Japan, 2006
      • 5510 Development of density dependent cell sorter using ultrasonic standing wave
        Hirabayashi Yasutoshi; Shintaku Hirofumi; Suzuki Takaaki; Kanno Isaku; Kotera Hidetoshi
        The Proceedings of Mechanical Engineering Congress, Japan, 2006
      • 745 Evaluation of dynamic damage on islets during purification process
        SHINTAKU Hirofumi; OKITSU Teru; MATSUMOTO Shinichi; KAWANO Satoyuki; SUZUKI Takaaki; KANNO Isaku; KOTERA Hidetoshi
        The Proceedings of Mechanical Engineering Congress, Japan, 2006
      • 259 Development of PZT/SUS unimorph microactuator and its application for traveling wave micropump
        SUZUKI Takaaki; NAGAO Taka; HATA Hidetoshi; SHINTAKU Hirofumi; KANNO Isaku; KOTERA Hidetoshi
        DD, 2005
      • 109 Visualization Method for Cylindrical Droplet Formation in Microchannel
        Shintaku Hirofumi; Kawano Satoyuki; Kuwabara Takeo; Suzuki Takaaki; Kanno Isaku; Kotera Hidetoshi
        The Proceedings of Mechanical Engineering Congress, Japan, 2005
      • 1119 Development of micro atomizer and its computer aided design
        SHINTAKU Hirofumi; KAWANO Satoyuki; SUZUKI Takaaki; KANNO Isaku; KOTERA Hidetoshi
        IIP, 2005
      • 1119 Development of micro atomizer based on theoretical approach
        SHINTAKU Hirofumi; KAWANO Satoyuki; SUZUKI Takaaki; KANNO Isaku; KOTERA Hidetoshi
        The Proceedings of Conference of Kansai Branch, 2005
      • Optimization of droplet generating method in a microchannel based on instability theory
        SHINTAKU Hirofumi; KAWANO Satoyuki; YAMAJI Yusuke; KANNO Isaku; KOTERA Hidetoshi
        The Proceedings of Mechanical Engineering Congress, Japan, 2004
      • Micro liquid mixing using pulsating flow at extremely low Reynolds numbers
        SHINTAKU Hirofumi; KAWANO Satoyuki; KANNO Isaku; KOTERA Hidetoshi
        The Proceedings of Mechanical Engineering Congress, Japan, 2004
      • Computer aided design of passive mixer for μTAS
        SHINTAKU Hirofumi; KAWANO Satoyuki; KANNO Isaku; KOTERA Hidetoshi
        The Proceedings of Mechanical Engineering Congress, Japan, 2003
      • A passive micromixer based on instability theory of interfacial wave growth
        SHINTAKU Hirofumi; KAWANO Satoyuki; KANNO Isaku; KOTERA Hidetoshi
        The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2003

      Industrial Property Rights

      • 特許第6288778号, 特願2014-545765, ポンプおよび送液方法
        川野 聡恭; 新宅 博文; モサ オスマン; オムラン オスマン; 平田 基徳
      • WO2017-131216, JP2017003069, 生体高分子分画用チップ、それを用いた生体高分子の分画方法、および生体高分子の分析方法
        新宅 博文; 藁谷 卓哉; 上村 想太郎; 小口 祐伴
      • 特表2017-505610, 特願2016-546015, 電気泳動技術を用いた単一細胞からのRNA及びDNAの同時抽出及び分離
        サンティアゴ; ファン、 ジー; 新宅 博文
      • 特許第6029056号, 特開2014-045937, 特願2012-191109, 人工感覚上皮
        川野 聡恭; 伊藤 壽一; 中川 隆之; 新宅 博文
      • WO2014-073638, JP2013080240, ポンプおよび送液方法
        川野 聡恭; 新宅 博文; モサ オスマン; オムラン オスマン; 平田 基徳
      • 特開2014-068612, 特願2012-218223, 高分子の伸長方法および高分子伸長装置
        川野 聡恭; 新宅 博文; 雪本 直哉; 上原 聡司; 谷口 正輝; 川合 知二
      • 特開2014-045937, 特願2012-191109, 人工感覚上皮
        川野 聡恭; 伊藤 壽一; 中川 隆之; 新宅 博文

      Awards

      • 14 Mar. 2025
        理化学研究所, 理研梅峰賞
        細胞の力学特性と遺伝子発現の統合解析法の開発, Japan, Japan society
        塩見晃史, 新宅博文, 金子泰洸ポール, 西川香里
      • 28 Feb. 2025
        中谷賞奨励賞(公益財団法人中谷財団)
      • 01 Aug. 2011
        第１回大阪大学功績賞（研究部門）
      • 22 Oct. 2014
        日本機械学会ﾏｲｸﾛ･ﾅﾉ工学部門 優秀講演論文表彰
      • 23 Apr. 2010
        日本機械学会奨励賞（研究）
      • 16 Mar. 2010
        優秀講演奨励賞（日本機械学会ＩＩＰ部門）
      • 01 Nov. 2006
        日本ＡＥＭ学会論文賞
      • 06 Mar. 2016
        第1回合田ﾌﾟﾛｸﾞﾗﾑ ImPACT ｾﾚﾝﾃﾞｨﾋﾟﾃｨ賞
      • 20 Aug. 2018
        シスメックス賞
      • 01 Feb. 2022
        優秀講演論文表彰（日本機械学会　マイクロ・ナノ工学部門）

      External funds: Kakenhi

      • Elucidation of the physiological role of heterogeneous hepatocytes and its application to drug discovery and medicine
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 90:Biomedical engineering and related fields
        The University of Tokyo
        Yasuyuki Sakai
        From 09 Jul. 2021, To 31 Mar. 2023, Project Closed
        肝細胞;創薬支援デバイス;肝機能;多核;ゾネーション
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19885/
      • Measurement of single-cell dynamics with nanoelectroporation
        Grant-in-Aid for Challenging Research (Pioneering)
        Medium-sized Section 28:Nano/micro science and related fields
        Kyoto University;Institute of Physical and Chemical Research
        Hirofumi Shintaku
        From 09 Jul. 2021, To 31 Mar. 2024, Project Closed
        1細胞;RNA-sequencing;マイクロ流体工学;オミクス;電気泳動;造血幹細胞
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K18194/
      • The dynamics of RNA transport in single cells
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 28:Nano/micro science and related fields
        Institute of Physical and Chemical Research
        Hirofumi Shintaku
        From 28 Jun. 2019, To 31 Mar. 2021, Project Closed
        1細胞;RNA;次世代シーケンス解析;マイクロ流体;分子バーコード;ナノポアシーケンサー;転写後制御;トランスクリプト;電気泳動;マイクロ流体工学;RNA-sequencing;細胞内小器官
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22121/
      • Electrophoretic analysis on cytoplasmic molecules and organelles in single cells using microfluidic fractionation
        Grant-in-Aid for Scientific Research (B)
        Basic Section 19010:Fluid engineering-related
        Institute of Physical and Chemical Research
        Hirofumi Shintaku
        From 01 Apr. 2019, To 31 Mar. 2022, Project Closed
        1細胞;RNA;次世代シーケンス解析;マイクロ流体;分子バーコード;電気泳動;マイクロ流体工学;RNA-sequencing;細胞内小器官;電気穿孔
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H02072/
      • Simultaneous extraction and analyses of RNA and DNA from single cells
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        HIROFUMI SHINTAKU
        From 01 Apr. 2014, To 31 Mar. 2017, Project Closed
        マイクロ流路;電気泳動;一細胞;RNA;DNA;シークエンシング;電気穿孔;前処理;マイクロ流体;動電現象;等速電気泳動法;タンパク;PCR
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26630052/
      • Double-face culture system for application of alveolar epithelial cells induced from human iPS cells
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Ito Isao
        From 01 Apr. 2014, To 31 Mar. 2017, Project Closed
        iPS細胞;肺胞上皮細胞;気道上皮細胞;肺前駆細胞;ナノファイバー;呼吸器疾患;肺気腫;再生医学;線毛上皮細胞;血管内皮細胞;ES細胞;nanofiber;microfluidics
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293199/
      • Micro and nano electroporation for direct delivery of molecules to cell nucleus
        Grant-in-Aid for Scientific Research (B)
        Institute of Physical and Chemical Research;Kyoto University
        Hirofumi Shintaku
        From 01 Apr. 2014, To 31 Mar. 2019, Project Closed
        RNA;DNA;電気泳動;マイクロ流体システム;シーケンシング;1細胞;電気穿孔;マイクロ流路;動電現象;生体高分子;細胞;一細胞;マイクロ流体;物質輸送
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26289035/
      • Development of U-shaped Microchannel for High Precise Fluid Measurement
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University;Osaka University
        Hirofumi SHINTAKU
        From 01 Apr. 2011, To 31 Mar. 2013, Project Closed
        流体計測;マイクロ流体;MEMS;微小流路;生体計測
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23656140/
      • Numerical Study on Interaction Integral for Improvement of QMD
        Grant-in-Aid for Challenging Exploratory Research
        Osaka University
        Kentaro DOI
        From 01 Apr. 2011, To 31 Mar. 2013, Project Closed
        分子流体力学;量子分子動力学;数値積分法;原子・分子物理;流体工学;量子力学;分子動力学
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23656139/
      • Visualization techniques for electrokinetic flow dynamics in confined nanospace
        Grant-in-Aid for Young Scientists (A)
        Kyoto University;Osaka University
        Hirofumi SHINTAKU
        From 01 Apr. 2010, To 31 Mar. 2014, Project Closed
        界面動電現象;ナノ制限空間;生体高分子;1分子計測;MEMS流体;一分子計測;マイクロ・ナノ流体;可視化;MEMS;DNAシーケンシング
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22686021/
      • Development of scientific principles on quantum molecular dynamics in confined nano-spaces
        Grant-in-Aid for Scientific Research (A)
        Osaka University
        SATOYUKI KAWANO
        From 01 Apr. 2010, To 31 Mar. 2015, Project Closed
        量子・分子流動ダイナミクス;制限ナノ空間;マイクロ・ナノデバイス;表面・界面;分子流体工学;分子流体力学;バイオナノ流動ダイナミクス;DNAシーケシング;イオンチャネル;次世代電池;人工臓器;環境工学;神経科学;DNAシークエンシング
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22246022/
      • Development of Single Molecule Analysis and Mathematical Model for Biomacromolecules Flowing Near Solid-liquid Interface
        Grant-in-Aid for Young Scientists (B)
        Osaka University
        Hirofumi SHINTAKU
        From 01 Apr. 2007, To 31 Mar. 2010, Project Closed
        バイオ流体工学;ナノバイオ;界面動電位;壁面効果;1分子計測;生体高分子微小流路;電場計測;電気二重層;生体高分子;微小流路;界面
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19760117/
      • Development of islet isolation technique to minimize tissue injury by applying nanotechnology
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Teru OKITSU
        From 01 Apr. 2007, To 31 Mar. 2010, Project Closed
        移植外科学;膵島移植;膵島分離;ナノテクノロジー;膵臓消化;ナノバブル;溶存酸素;シラス多孔質ガラス膜;膵島純化;せん断;粘度
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390333/
      • Integrated single-cell analysis of phenotype and gene expression
        Grant-in-Aid for Scientific Research (B)
        Basic Section 28050:Nano/micro-systems-related
        Kyoto University
        新宅 博文
        From 01 Apr. 2024, To 31 Mar. 2027, Granted
        1細胞;マイクロ流体工学;電気泳動;RNA-sequencing
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K01318/
      list
        Last Updated :2025/05/24

        Education

        Teaching subject(s)

        • From 01 Apr. 2024, To 31 Mar. 2025
          Biomechanical Engineering
          5301, Fall, Faculty of Engineering, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Introduction to Engineering Science A
          5110, Fall, Faculty of Engineering, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          ILAS Seminar
          Z001, Spring, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Biomechanical Engineering
          5301, Fall, Faculty of Engineering, 2

        Participation in PhD Defense

        • 骨形態形成における多細胞動態の連続体力学解析
          YOKOYAMA YUKA, Graduate School of Engineering, Sub-chief Examiner
          25 Mar. 2024

        Student achievements: Awards

        • 日本機械学会奨励賞（研究）
          塩見晃史, 日本機械学会, 24 Apr. 2025
        • 理研梅峰賞
          塩見晃史，新宅博文，金子泰洸ポール，西川香里, 理化学研究所, 14 Mar. 2025
        • 日本機械学会若手優秀講演フェロー賞
          野﨑佳司, 日本機械学会, 16 Dec. 2024
        • 若手優秀講演表彰
          峯岸美紗, 日本機械学会 マイクロ・ナノ工学部門, 16 Dec. 2024
        • ファイナリスト認定証
          塩見晃史, 日本機械学会 マイクロ・ナノ工学部門, 27 Nov. 2024
        • Outstanding Young Scientist TOMY Award
          Taikopaul Kaneko, The 30th East Asia Joint Symposium, 31 Oct. 2024
        • The Poster Award
          Misa Minegishi, the 19th International Symposium of the Institute Network for Biomedical Sciences in Sendai, 12 Oct. 2024
        • ポスター賞
          金子泰洸ポール, 京都大学 医生物学研究所2024年度リトリート, 03 Sep. 2024
        • YORC発表賞
          峯岸美紗, JST-CREST 多細胞 若手の会 2024, 27 Aug. 2024
        • YORC発表賞
          塩見晃史, JST-CREST 多細胞 若手の会 2024, 27 Aug. 2024
        • IUPAB2024 Student and Early Career Researcher Poster Award
          Akifumi Shiomi, IUPAB2024, 28 Jun. 2024
        • 若手招待講演賞
          峯岸美紗, 日本生物物理学会, 27 Jun. 2024
        • Best Poster Award
          Taikopaul Kaneko, Serendipity Symposium, 13 Mar. 2024
        • 桜舞賞 研究奨励賞
          峯岸美紗, 理化学研究所, 12 Mar. 2024
        • ポスター賞
          金子泰洸ポール, 理化学研究所　第27回 異分野交流の夕べ, 22 Feb. 2024
        • Recognition of the outstanding poster
          Taikopaul Kaneko, 2023 Physics and Chemistry of Microfluidics,, Gordon Research Conference, 08 Jul. 2023
        list
          Last Updated :2025/05/24

          Administration

          Faculty management (title, position)

          • From 01 Apr. 2024
            共同利用機器等委員会　委員長
          • From 01 Apr. 2023, To 31 Mar. 2024
            共同利用機器等委員会　委員
          • From 01 Apr. 2023, To 31 Mar. 2024
            化学物質管理委員会　委員
          • From 01 Apr. 2023
            再生実験動物施設飼育室施設運営委員会　委員

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