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Hasegawa, Emi
Graduate School of Pharmaceutical Sciences, Division of Bioinformatics and Chemical Genomics Associate Professor
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Last Updated :2025/04/29
Basic Information
Faculty
Email Address
Email Address
hasegawa.emi.3s
kyoto-u.ac.jp
Professional Memberships
Academic Degree
Academic Resume (Undergraduate School/Majors)
Research History
- From Jan. 2023, To PresentKyoto University, Graduate School of Pharmaceutical Sciences Division of Bioinformatics and Chemical Genomics, Associate Professor
- From Nov. 2020, To Dec. 2022筑波大学 医学医療系, 助教
- From Sep. 2016, To Dec. 2022University of Tsukuba, International Institute for Integrative Sleep Medicine, 助教
- From Nov. 2015, To Aug. 2016金沢大学大学院 医薬保健学総合研究域, 助教
- From Apr. 2015, To Oct. 2015金沢大学大学院 医薬保健学総合研究科 脳医科学専攻, 分子神経科学・統合生理学, 日本学術振興会特別研究員PD
- From Apr. 2013, To Mar. 2015金沢大学大学院 医薬保健学総合研究科 脳医科学専攻, 分子神経科学・統合生理学, 日本学術振興会特別研究員DC1
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40765955External link
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Last Updated :2025/04/29
Research
Research Interests
Research Areas
Papers
- Identification of angiotensin II-responsive circadian clock gene expression in adrenal zona glomerulosa cells and human adrenocortical H295R cellsTomohiro Otani; Takahito Miyake; Takumi Ota; Daisuke Yarimizu; Yuuki Nakagawa; Iori Murai; Hitoshi Okamura; Emi Hasegawa; Masao DoiFrontiers in Endocrinology, 26 Mar. 2025
- Identification of meibomian gland testosterone metabolites produced by tissue-intrinsic intracrine deactivation activityKhanh Tien Nguyen Pham; Takahito Miyake; Tomo Suzuki; Shigeru Kinoshita; Yuki Hamada; Hikari Uehara; Mamiko Machida; Takeshi Nakajima; Emi Hasegawa; Masao DoiiScience, Feb. 2025
- Size-reduced DREADD derivatives for AAV-assisted multimodal chemogenetic control of neuronal activity and behavior.Takahito Miyake; Kaho Tanaka; Yutsuki Inoue; Yuji Nagai; Reo Nishimura; Takehito Seta; Shumpei Nakagawa; Ken-Ichi Inoue; Emi Hasegawa; Takafumi Minamimoto; Masao DoiCell reports methods, 21 Oct. 2024, Peer-reviewed
- Omeprazole Induces <i>CYP3A4</i> mRNA Expression but Not CYP3A4 Protein Expression in HepaRG CellsYuto Fujita; Takahito Miyake; Xinyan Shao; Yuto Aoki; Emi Hasegawa; Masao DoiBiological and Pharmaceutical Bulletin, 27 Jun. 2024
- Temperature-Dependent Upregulation of Per2 Protein Expression Is Mediated by eIF2α Kinases PERK and PKR through PI3K ActivationXinyan Shao; Takahito Miyake; Yuichi Inoue; Emi Hasegawa; Masao DoiBiological and Pharmaceutical Bulletin, 05 Mar. 2024
- Monoamines Inhibit GABAergic Neurons in Ventrolateral Preoptic Area That Make Direct Synaptic Connections to Hypothalamic Arousal Neurons.Saito YC*; Maejima T*; Nishitani M; Hasegawa E; Yanagawa Y; Mieda M; Sakurai TThe Journal of neuroscience : the official journal of the Society for Neuroscience, Jul. 2018, Peer-reviewed
- Regulation of REM sleep in mice: The role of dopamine and serotonin function in the basolateral amygdalaEmi Hasegawa; Yulong Li; Takeshi SakuraiNeuroscience Research, Sep. 2023
- Connecting the amygdala and dopamine: exploring the mysteries of rapid-eye movement sleepTakeshi Sakurai; Emi HasegawaSLEEP, 15 Jun. 2023
- Editorial: Neurobiology of sleeping behaviorsEmi Hasegawa; Yo Oishi; Daniel Kroeger; Tomomi Tsunematsu; Yves DauvilliersFrontiers in Behavioral Neuroscience, 17 Jan. 2023
- Lateral habenula glutamatergic neurons projecting to the dorsal raphe nucleus promote aggressive arousal in mice.Aki Takahashi; Romain Durand-de Cuttoli; Meghan E Flanigan; Emi Hasegawa; Tomomi Tsunematsu; Hossein Aleyasin; Yoan Cherasse; Ken Miya; Takuya Okada; Kazuko Keino-Masu; Koshiro Mitsui; Long Li; Vishwendra Patel; Robert D Blitzer; Michael Lazarus; Kenji F Tanaka; Akihiro Yamanaka; Takeshi Sakurai; Sonoko Ogawa; Scott J RussoNature communications, 21 Jul. 2022
- Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library.Tsuyoshi Saitoh; Mao Amezawa; Jumpei Horiuchi; Yasuyuki Nagumo; Naoshi Yamamoto; Noriki Kutsumura; Ryuichiro Ohshita; Akihisa Tokuda; Yoko Irukayama-Tomobe; Yasuhiro Ogawa; Yukiko Ishikawa; Emi Hasegawa; Takeshi Sakurai; Yasuo Uchida; Tetsu Sato; Hiroaki Gouda; Ryuji Tanimura; Masashi Yanagisawa; Hiroshi NagaseEuropean journal of medicinal chemistry, 13 Jun. 2022
- Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice.Emi Hasegawa; Ai Miyasaka; Katsuyasu Sakurai; Yoan Cherasse; Yulong Li; Takeshi SakuraiScience (New York, N.Y.), 04 Mar. 2022
- GABA from vasopressin neurons regulates the time at which suprachiasmatic nucleus molecular clocks enable circadian behaviorMaejima, Takashi; Tsuno, Yusuke; Miyazaki, Shota; Tsuneoka, Yousuke; Hasegawa, Emi; Islam, Md Tarikul; Enoki, Ryosuke; Nakamura; Takahiro J; Mieda, MichihiroProceedings of the National Academy of Sciences of the United States of America, Feb. 2021
- A discrete neuronal circuit induces a hibernation-like state in rodentsTakahashi, Tohru M; Sunagawa; Genshiro A; Soya, Shingo; Abe, Manabu; Sakurai, Katsuyasu; Ishikawa, Kiyomi; Yanagisawa, Masashi; Hama, Hiroshi; Hasegawa, Emi; Miyawaki, Atsushi; Sakimura, Kenji; Takahashi, Masayo; Sakurai, TakeshiNature, Jun. 2020
- Large-scale forward genetics screening identifies Trpa1 as a chemosensor for predator odor-evoked innate fear behaviorsYibing Wang; Liqin Cao; Chia-Ying Lee; Tomohiko Matsuo; Kejia Wu; Greg Asher; Lijun Tang; Tsuyoshi Saitoh; Jamie Russell; Daniela Klewe-Nebenius; Li Wang; Shingo Soya; Emi Hasegawa; Yoan Chérasse; Jiamin Zhou; Yuwenbin Li; Tao Wang; Xiaowei Zhan; Chika Miyoshi; Yoko Irukayama; Jie Cao; Julian P. Meeks; Laurent Gautron; Zhiqiang Wang; Katsuyasu Sakurai; Hiromasa Funato; Takeshi Sakurai; Masashi Yanagisawa; Hiroshi Nagase; Reiko Kobayakawa; Ko Kobayakawa; Bruce Beutler; Qinghua LiuNature Communications, 01 Dec. 2018
- Sleep and wakefulness are controlled by ventral medial midbrain/pons GABAergic neurons in miceTakata, Yohko; Oishi, Yo; Zhou, Xu-Zhao; Hasegawa, Emi; Takahashi, Koji; Cherasse, Yoan; Sakurai, Takeshi; Lazarus, MichaelThe Journal of neuroscience, Oct. 2018, Peer-reviewed
- Monoamines Inhibit GABAergic Neurons in Ventrolateral Preoptic Area that make Direct Synaptic Connections to Hypothalamic Arousal NeuronsSaito, Yuki; Maejima, Takashi; Nishitani, Mitsuhiro; Hasegawa, Emi; Yanagawa, Yuchio; Mieda, Michihiro; Sakurai, TakeshiThe Journal of neuroscience : the official journal of the Society for Neuroscience, Jun. 2018, Peer-reviewed
- Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing amygdala activityEmi Hasegawa; Takashi Maejima; Takayuki Yoshida; Olivia A. Masseck; Stefan Herlitze; Mitsuhiro Yoshioka; Takeshi Sakurai; Michihiro MiedaProceedings of the National Academy of Sciences of the United States of America, 25 Apr. 2017, Peer-reviewed
- Fine-Tuning Circadian Rhythms: The Importance of Bmal1 Expression in the Ventral ForebrainMichihiro Mieda; Emi Hasegawa; Nicoletta Kessaris; Takeshi SakuraiFRONTIERS IN NEUROSCIENCE, Feb. 2017, Peer-reviewed
- Cellular Clocks in AVP Neurons of the SCN Are Critical for Interneuronal Coupling Regulating Circadian Behavior RhythmMichihiro Mieda; Daisuke Ono; Emi Hasegawa; Hitoshi Okamoto; Ken-ichi Honma; Sato Honma; Takeshi SakuraiNEURON, Mar. 2015, Peer-reviewed
- Orexin neurons suppress narcolepsy via 2 distinct efferent pathwaysEmi Hasegawa; Masashi Yanagisawa; Takeshi Sakurai; Michihiro MiedaJOURNAL OF CLINICAL INVESTIGATION, Feb. 2014, Peer-reviewed
- GABAergic neurons in the preoptic area send direct inhibitory projections to orexin neuronsYuki C. Saito; Natsuko Tsujino; Emi Hasegawa; Kaori Akashi; Manabu Abe; Michihiro Mieda; Kenji Sakimura; Takeshi SakuraiFRONTIERS IN NEURAL CIRCUITS, Dec. 2013, Peer-reviewed
- Orexin Receptor-1 in the Locus Coeruleus Plays an Important Role in Cue-Dependent Fear Memory ConsolidationShingo Soya; Hirotaka Shoji; Emi Hasegawa; Mari Hondo; Tsuyoshi Miyakawa; Masashi Yanagisawa; Michihiro Mieda; Takeshi SakuraiJOURNAL OF NEUROSCIENCE, Sep. 2013, Peer-reviewed
- Differential Roles of Orexin Receptor-1 and-2 in the Regulation of Non-REM and REM SleepMichihiro Mieda; Emi Hasegawa; Yaz Y. Kisanuki; Christopher M. Sinton; Masashi Yanagisawa; Takeshi SakuraiJOURNAL OF NEUROSCIENCE, Apr. 2011, Peer-reviewed
Presentations
- 睡眠周期の生成における扁桃体とドーパミンの役割第66回日本老年医学会学術集会, Jun. 2024, Invited
- Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in miceEmi Hasegawa第28回日本睡眠学会研究奨励賞受賞講演, Sep. 2023, Invited
- Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in miceEmi HasegawaSleep2023, Jun. 2023, Invited
- Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in miceEmi HasegawaThe 11th Annual WPI-IIIS Symposium, Feb. 2023, Invited
- Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice長谷川, 恵美第268回つくばブレインサイエンス・セミナー, May 2022
- Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice長谷川, 恵美第4回三融会・武田神経科学シンポジウム, Apr. 2022
- Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in miceHasegawa, EmiJST-CREST “Opt Bio” / WPI-IIIS Joint Symposium, Mar. 2022
- Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in miceHasegawa, EmiWPI-IIIS/Fudan University Joint Symposium, Feb. 2022
- 情動脱力発作における扁桃体のドーパミンシグナルの役割長谷川, 恵美第16回GPCR研究会, Nov. 2021
- REM睡眠開始における扁桃体基底外側核のドーパミンシグナルの役割長谷川, 恵美第16回GPCR研究会, Nov. 2021
- REM睡眠開始における扁桃体基底外側核のドーパミンシグナルの役割長谷川, 恵美日本睡眠学会第46回定期学術集会, Sep. 2021
- 1,3,5-Trioxazatriquinane骨格を用いたオレキシン受容体拮抗薬の開発雨澤真櫻; 斉藤毅; 堀内惇平; 大下隆一郎; 山本直司; 南雲康行; 沓村, 憲樹; 石川有紀子; 入鹿山容子; 長谷川恵美; 小川靖裕; 徳田明久; 合田浩明; 谷村隆次; 櫻井武; 柳沢正史; 長瀬博日本ケミカルバイオロジー学会 第15回年会, 21 Jun. 2021, 日本ケミカルバイオロジー学会
- Neural circuits of cataplexy,Hasegawa, EmiWorld sleep 2019, Sep. 2019
- Neural circuits of cataplexyHasegawa, EmiWorld sleep 2019, Sep. 2019
- Dopamine release into the amygdala might be involved in REM-related muscle atoniaHasegawa, EmiAmygdala Function in Emotion, Cognition and Disease Gordon Research Conference, Aug. 2019
- レム睡眠関連脱力発作における扁桃体へのドーパミン放出の影響長谷川, 恵美第42回日本神経科学大会, Jul. 2019
- Orexin System In Fear Memory FormationSoya, Shingo; Shoji, Hirotaka; Hasegawa, Emi; Hondo, Mari; Miyakawa, Tsuyoshi; Yanagisawa, Masashi; Mieda, Michihiro; Sakurai, TakeshiFENS forum, Aug. 2014
- Orexin Receptor-1 in the Locus Coeruleus Plays an Important Role in Cue-Dependent Fear Memory ConsolidationShingo, Soya; Shoji, hirotaka; Emi, Hasegawa; Mari, Hondo; Tsuyoshi, Miyakawa; Masashi, Yanagisawa; Michihiro, Mieda; Takeshi, sakuraiSfN meeting, Nov. 2013
Books and Other Publications
- 睡眠学百科事典Joint work, ナルコレプシー動物モデル丸善出版, Jun. 2024
- レム睡眠の開始機構－睡眠周期の生成に関するドーパミンと扁桃体の新たな役割長谷川恵美, Single work, P1303-1308Brain and Nerve・医学書院, Nov. 2022
- 睡眠／覚醒調節の謎に挑む：明らかになったレム睡眠の開始におけるドーパミンと扁桃体の役割長谷川, 恵美Neuro Logica, May 2022
- オレキシン：覚醒の安定化機構長谷川, 恵美月刊医学総合誌「Progress in Medicine」ライフサイエンス, Dec. 2021
- オレキシンシステムによる睡眠・覚醒制御機構長谷川, 恵美FOOD STYLE 21（食品の機能と健康を考える科学情報誌）, Sep. 2020
- ナルコレプシーの病態：オレキシンニューロンの下流でナルコレプシー症状抑制に関与している神経経路の探索長谷川, 恵美『分子精神医学』第73号、先端医学社, Oct. 2018
- オレキシンニューロンの下流でナルコレプシー症状抑制に関与している神経経路長谷川, 恵美医学のあゆみ、医歯薬出版株式会社, Dec. 2017
- オレキシン産生神経細胞は2つの異なる神経経路でナルコレプシーを抑制する長谷川, 恵美実験医学、羊土社, Nov. 2014
Awards
- 07 Apr. 2023令和５年度 科学技術分野の文部科学大臣表彰 若手科学者賞
- 16 Sep. 2023第28回 日本睡眠学会睡眠研究奨励賞
- 02 Aug. 20232023年度 日本神経科学学会奨励賞
- 19 Apr. 2023令和5年度科学技術分野文部科学大臣表彰（若手科学者賞）
- 03 Feb. 2023第15回（2023年度）井上リサーチアウォード
- 16 Sep. 2019World Sleep 2019 Young Investigator Award
- 16 Jul. 2018FENS-IBRO/PERC travel gran in FENS Forum 2018 Berlin
- 12 Feb. 2018第34回（2017年度）井上研究奨励賞
- 14 Dec. 2015Optogenetics 2015 Poster Award
- 14 Sep. 2015ASIA(Asian Forum on Chronobiology in 2015) Travel Grant
- 26 Jun. 2015第13回 高安賞最優秀論文賞
- 24 Mar. 2014GRC Award
- 17 Sep. 2012ESRS2012 Travel Grant
- 23 Mar. 2012平成23年度 金沢大学大学院医学系研究科医科学専攻優秀論文賞
External funds: Kakenhi
- REM睡眠開始における扁桃体基底外側核のドーパミンシグナルの役割の解明Grant-in-Aid for Scientific Research (C)Basic Section 48020:Physiology-relatedKyoto University長谷川 恵美From 01 Apr. 2022, To 31 Mar. 2025, Grantedレム睡眠;ドーパミン;扁桃体;マウス;睡眠
- The analysis of neural pathways in arousal maintenance and behavioral alteration under orexinGrant-in-Aid for Early-Career ScientistsBasic Section 46030:Function of nervous system-relatedUniversity of TsukubaEmi HasegawaFrom 01 Apr. 2018, To 31 Mar. 2022, Project Closed睡眠;ドーパミン;扁桃体;オレキシン;カタプレキシー;ファイバーフォトメトリー法;in vivoレコーディングシステム;睡眠・覚醒;報酬系;ナルコレプシー;光遺伝学的手法;マルチユニット記録;覚醒・睡眠
- Elucidation of sleep-regulatory mechanisms by the reward systemGrant-in-Aid for Scientific Research (B)Basic Section 46020:Anatomy and histopathology of nervous system-relatedUniversity of TsukubaYo OishiFrom 01 Apr. 2018, To 31 Mar. 2023, Project Closed睡眠;GABA;腹側被蓋野;覚醒;マウス;ドーパミン;化学遺伝学;VTA;VMP
- The neurophysiological analysis of neuronal type selective in the circadian clockGrant-in-Aid for Young Scientists (B)University of TsukubaEmi HASEGAWAFrom 01 Apr. 2016, To 31 Mar. 2018, Project Closed中枢概日時計;視交叉上核（SCN）;電気生理学的特性;GABA受容体;パッチクランプ法;神経科学;生理学
- Analysis of sleep-wake regulatory system by optogenetics featuring cone opsins.Grant-in-Aid for Scientific Research (C)Kanazawa UniversityTakashi MaejimaFrom 01 Apr. 2015, To 31 Mar. 2018, Project Closed睡眠・覚醒;光遺伝学;錐体オプシン;オレキシン;セロトニン;ノルアドレナリン;ヒスタミン
list
Last Updated :2025/04/29
Education
Teaching subject(s)
- From 01 Apr. 2024, To 31 Mar. 2025Research Proposal Writing Practice A8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2024, To 31 Mar. 2025Pharmaceutical Laboratory Coaching Practice B8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2024, To 31 Mar. 2025Pharmaceutical Laboratory Coaching Practice A8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2024, To 31 Mar. 2025Research Proposal Writing Practice B8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2024, To 31 Mar. 2025Physiology 1 (Anatomical Physiology)A301, Fall, Faculty of Pharmaceutical Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025Physiology 4 (Genomic medicine)A304, Spring, Faculty of Pharmaceutical Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025Physiology III (Clinical Physiology)C304, Spring, Faculty of Pharmaceutical Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025Physiology I (Basic Physiology)C301, Fall, Faculty of Pharmaceutical Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025Seminar on Critical Reading of Scientific Papers B8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025Seminar on Critical Reading of Scientific Papers A8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025Medicinal Frontier Science Research A8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2024, To 31 Mar. 2025Pharmaceutical Laboratory III : Pharmaceutics and PharmacologyC905, Fall, Faculty of Pharmaceutical Sciences, 3
- From 01 Apr. 2024, To 31 Mar. 2025Medicinal Frontier Science Research B8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2023, To 31 Mar. 2024Research Proposal Writing Practice B8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2023, To 31 Mar. 2024Research Proposal Writing Practice A8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2023, To 31 Mar. 2024Pharmaceutical Laboratory Coaching Practice B8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2023, To 31 Mar. 2024Pharmaceutical Laboratory Coaching Practice A8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
- From 01 Apr. 2023, To 31 Mar. 2024Research in Systems Biology & Drug Dicovery5301, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2023, To 31 Mar. 2024Medicinal Frontier Science Research B8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2023, To 31 Mar. 2024Medicinal Frontier Science Research A8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
- From 01 Apr. 2023, To 31 Mar. 2024Seminar on Critical Reading of Scientific Papers B8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
- From 01 Apr. 2023, To 31 Mar. 2024Seminar on Critical Reading of Scientific Papers A8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
- From 01 Apr. 2023, To 31 Mar. 2024Advanced Methods in Systems Biology & Drug Discovery5501, Year-long, Graduate School of Pharmaceutical Sciences, 2
- From 01 Apr. 2023, To 31 Mar. 2024Physiology 1 (Anatomical Physiology)A301, Fall, Faculty of Pharmaceutical Sciences, 2
- From 01 Apr. 2023, To 31 Mar. 2024Physiology III (Clinical Physiology)C304, Spring, Faculty of Pharmaceutical Sciences, 2
- From 01 Apr. 2023, To 31 Mar. 2024Physiology I (Basic Physiology)C301, Fall, Faculty of Pharmaceutical Sciences, 2
- From 01 Apr. 2023, To 31 Mar. 2024Physiology 4 (Genomic medicine)A304, Spring, Faculty of Pharmaceutical Sciences, 2
