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Ohgushi, Masatoshi
Institute for Life and Medical Sciences (LiMe) Associate Professor
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Last Updated :2025/06/25
Basic Information
Affiliated programs (koza)
Academic Degree
Research History
- From Apr. 2022, To Present京都大学 医生物学研究所, 発生システム制御分野, 准教授
- From Jan. 2018, To Mar. 2022京都大学 ウイルス・再生医化学研究所, 発生システム制御分野, 准教授
- From Apr. 2016, To Dec. 2017国立研究開発法人理化学研究所 多細胞システム形成研究センター, 立体組織形成研究チーム, 上級研究員
- From Nov. 2014, To Mar. 2016国立研究開発法人理化学研究所 多細胞システム形成研究センター, 多能性幹細胞研究チーム, 上級研究員
- From Oct. 2010, To Nov. 2014独立行政法人理化学研究所 発生・再生科学総合研究センター, 幹細胞研究支援・開発室 ヒト幹細胞研究支援ユニット, 副ユニットリーダー
- From Jun. 2007, To Sep. 2010独立行政法人理化学研究所 発生・再生科学総合研究センター, ヒト幹細胞支援室, 研究員
- From Apr. 2006, To May 2007Kyoto University Graduate School of Biostudies, 産学官連携研究員
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ORCID ID
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Last Updated :2025/06/25
Research
Research Topics, Overview of the research
Research Topics
Characterization and application of human pluripotent stem cellsOverview of the research
Human pluripotent stem cells, including embryonic stem cells and induced pluripotent stem cells, hold hold huge potential as reproductive resources for cell-therapies as well as for drug discovery. In order to further expand thier applications, we are working on detailed analyses of pluripotency and differentiation potency of human pluripotent stem cells.
Research Interests
Research Areas
Papers
- Spatial cell fate manipulation of human pluripotent stem cells by controlling the microenvironment using photocurable hydrogelZhe Wang; Akira Numada; Fumi Wagai; Yusuke Oda; Masatoshi Ohgushi; Koichiro Maki; Taiji Adachi; Mototsugu EirakuDevelopment, 15 Mar. 2024, Peer-reviewed
- Delamination of trophoblast-like syncytia from the amniotic ectodermal analogue in human primed embryonic stem cell-based differentiation model.Masatoshi Ohgushi; Nobuko Taniyama; Alexis Vandenbon; Mototsugu EirakuCell Reports, 21 Jun. 2022, Peer-reviewed, Lead author, Corresponding author
- A Practical Protocol for the Conditional Depletion of Rho Isoforms in Human Embryonic Stem Cells.OGUSHI MasatoshiMethods in Molecular Biology, Jul. 2018, Peer-reviewed, Invited, Lead author, Corresponding author
- A RHO Small GTPase Regulator ABR Secures Mitotic Fidelity in Human Embryonic Stem CellsMasatoshi Ohgushi; Maki Minaguchi; Mototsugu Eiraku; Yoshiki SasaiSTEM CELL REPORTS, Jul. 2017, Peer-reviewed, Lead author, Corresponding author
- Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissueHideya Sakaguchi; Taisuke Kadoshima; Mika Soen; Nobuhiro Narii; Yoshihito Ishida; Masatoshi Ohgushi; Jun Takahashi; Mototsugu Eiraku; Yoshiki SasaiNATURE COMMUNICATIONS, Nov. 2015, Peer-reviewed
- Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem CellsMasatoshi Ohgushi; Maki Minaguchi; Yoshiki SasaiCELL STEM CELL, Oct. 2015, Peer-reviewed, Lead author, Corresponding author
- Feeder-Free Generation and Long-Term Culture of Human Induced Pluripotent Stem Cells Using Pericellular Matrix of Decidua Derived Mesenchymal CellsHayato Fukusumi; Tomoko Shofuda; Daisuke Kanematsu; Atsuyo Yamamoto; Hiroshi Suemizu; Masato Nakamura; Mami Yamasaki; Masatoshi Ohgushi; Yoshiki Sasai; Yonehiro KanemuraPLoS ONE, 31 Jan. 2013, Peer-reviewed
- Self-formation of functional adenohypophysis in three-dimensional cultureHidetaka Suga; Taisuke Kadoshima; Maki Minaguchi; Masatoshi Ohgushi; Mika Soen; Tokushige Nakano; Nozomu Takata; Takafumi Wataya; Keiko Muguruma; Hiroyuki Miyoshi; Shigenobu Yonemura; Yutaka Oiso; Yoshiki SasaiNATURE, Dec. 2011, Peer-reviewed
- Lonely death dance of human pluripotent stem cells: ROCKing between metastable cell statesMasatoshi Ohgushi; Yoshiki SasaiTRENDS IN CELL BIOLOGY, May 2011, Peer-reviewed, Invited, Lead author
- Intrinsic transition of embryonic stem-cell differentiation into neural progenitors.Daisuke Kamiya; Satoe Banno; Noriaki Sasai; Masatoshi Ohgushi; Hidehiko Inomata; Kiichi Watanabe; Masako Kawada; Rieko Yakura; Hiroshi Kiyonari; Kazuki Nakao; Lars Martin Jakt; Shin-ichi Nishikawa; Yoshiki SasaiNature, 24 Feb. 2011, Peer-reviewed
- Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem CellsMasatoshi Ohgushi; Michiru Matsumura; Mototsugu Eiraku; Kazuhiro Murakami; Toshihiro Aramaki; Ayaka Nishiyama; Keiko Muguruma; Tokushige Nakano; Hidetaka Suga; Mono Ueno; Toshimasa Ishizaki; Hirofumi Suemori; Shuh Narumiya; Hitoshi Niwa; Yoshiki SasaiCELL STEM CELL, Aug. 2010, Peer-reviewed, Lead author
- Pericellular Matrix of Decidua-Derived Mesenchymal Cells: A Potent Human-Derived Substrate for the Maintenance Culture of Human ES CellsTomoko Nagase; Morio Ueno; Michiru Matsumura; Keiko Muguruma; Masatoshi Ohgushi; Naomi Kondo; Daisuke Kanematsu; Yonehiro Kanemura; Yoshiki SasaiDEVELOPMENTAL DYNAMICS, May 2009, Peer-reviewed
- Bridging the gap from frog research to human therapy: A tale of neural differentiation in Xenopus animal caps and human pluripotent cellsYoshiki Sasai; Masatoshi Ogushi; Tomoko Nagase; Satoshi AndoDEVELOPMENT GROWTH & DIFFERENTIATION, Jun. 2008, Peer-reviewed
- 細胞死の生物学 アポトーシスシグナルからみえてきた新しい生理機能 TGF‐βによる細胞死制御と生理機構大串雅俊; 黒木俊介; 米原伸バイオニクス, Mar. 2007, Invited
- Transforming growth factor beta-dependent sequential activation of Smad, Bim, and caspase-9 mediates physiological apoptosis in gastric epithelial cellsM Ohgushi; S Kuroki; H Fukamachi; LA O'Reilly; K Kuida; A Strasser; S YoneharaMOLECULAR AND CELLULAR BIOLOGY, Nov. 2005, Peer-reviewed, Lead author
- FR901228 induces tumor regression associated with induction of Fas ligand and activation of Fas signaling in human osteosarcoma cellsT Imai; S Adachi; K Nishijo; M Ohgushi; M Okada; T Yasumi; K Watanabe; R Nishikomori; T Nakayama; S Yonehara; J Toguchida; T NakahataONCOGENE, Dec. 2003, Peer-reviewed
Misc.
- 培養細胞と医療(基礎研究) ヒト脱落膜由来細胞の細胞外マトリクスを用いたヒトES細胞の維持培養法長瀬 朋子; 上野 盛夫; 松村 みちる; 六車 恵子; 大串 雅俊; 近藤 直実; 兼松 大介; 金村 米博; 笹井 芳樹組織培養研究, Mar. 2009
External funds: Kakenhi
- Exporing role of cell-cell communication in human embryonic stem cellsGrant-in-Aid for Scientific Research (C)Kyoto UniversityMasatoshi OhgushiFrom 01 Apr. 2017, To 31 Mar. 2020, Project ClosedヒトES細胞;多能性;細胞間接着;セマフォリン;ゲノム編集;シグナル伝達;ヒト多能性幹細胞;細胞間コミュニケーション
- Chromosome stability by Rho-family small GTPase regulator in human embryonic stem cellsGrant-in-Aid for Young Scientists (B)Institute of Physical and Chemical ResearchOhgushi MasatoshiFrom 01 Apr. 2014, To 31 Mar. 2017, Project ClosedヒトES細胞;染色体安定性;Rhoシグナル経路;多能性幹細胞;ゲノム不安定性;ヒト多能性幹細胞;異数染色体
- Molecular analyses of cellular adhesion-dependent survival signal pathway in human pluripitent cellsGrant-in-Aid for Young Scientists (B)The Institute of Physical and Chemical ResearchMasatoshi OHGUSHIFrom 01 Apr. 2011, To 31 Mar. 2013, Project Closed多能性幹細胞;シグナル伝達;細胞間接着;細胞死;発生・分化
- 幹細胞を用いた羊膜前駆細胞の発生機序と細胞特性解析Grant-in-Aid for Scientific Research (B)Basic Section 42030:Animal life science-relatedKyoto University大串 雅俊From 01 Apr. 2022, To 31 Mar. 2025, GrantedヒトES細胞;胚体外組織;羊膜外胚葉;栄養外胚葉
- 幹細胞を用いた羊膜前駆細胞の発生機序と細胞特性解析Grant-in-Aid for Scientific Research (B)Basic Section 42030:Animal life science-relatedKyoto University大串 雅俊From 01 Apr. 2022, To 31 Mar. 2025, GrantedヒトES細胞;胚体外組織;羊膜外胚葉;栄養外胚葉
- ヒト特有の非栄養外胚葉系譜胎盤細胞の検証と性状解析Grant-in-Aid for Challenging Research (Exploratory)Medium-sized Section 48:Biomedical structure and function and related fieldsKyoto University大串 雅俊From 28 Jun. 2024, To 31 Mar. 2027, GrantedヒトES細胞;羊膜外胚葉;栄養外胚葉
list
Last Updated :2025/06/25
Education
Teaching subject(s)
- From 01 Apr. 2025, To 31 Mar. 2026創成化学実験Ⅰ・Ⅱ（創成化学）Year-long, 工学部
- From 01 Apr. 2025, To 31 Mar. 2026Chemical Biology7129, Fall, Faculty of Engineering, 2
- From 01 Apr. 2025, To 31 Mar. 2026Life and Medical Sciences, Adv.H665, Spring, Graduate School of Engineering, 1.5
- From 01 Apr. 2025, To 31 Mar. 2026Life and Medical SciencesH663, Spring, Graduate School of Engineering, 1.5
- From 01 Apr. 2024, To 31 Mar. 2025Chemical Biology7129, Fall, Faculty of Engineering, 2
- From 01 Apr. 2024, To 31 Mar. 2025ILAS SeminarZ001, Spring, Institute for Liberal Arts and Sciences, 2
- From 01 Apr. 2024, To 31 Mar. 2025Life and Medical SciencesH663, Spring, Graduate School of Engineering, 1.5
- From 01 Apr. 2024, To 31 Mar. 2025Life and Medical Sciences, Adv.H665, Spring, Graduate School of Engineering, 1.5
- From 01 Apr. 2023, To 31 Mar. 2024Chemical Biology7129, Fall, Faculty of Engineering, 2
- From 01 Apr. 2023, To 31 Mar. 2024Life and Medical Sciences, Adv.H665, Spring, Graduate School of Engineering, 1.5
- From 01 Apr. 2023, To 31 Mar. 2024Life and Medical SciencesH663, Spring, Graduate School of Engineering, 1.5
- From 01 Apr. 2022, To 31 Mar. 2023Life and Medical Sciences, Adv.H665, Spring, Graduate School of Engineering, 1.5
- From 01 Apr. 2022, To 31 Mar. 2023Life and Medical SciencesH663, Spring, Graduate School of Engineering, 1.5
- From 01 Apr. 2022, To 31 Mar. 2023Chemical Biology7129, Fall, Faculty of Engineering, 2
- From Apr. 2018, To Mar. 2019Chemical BiologyFall, 工学部
- From Apr. 2018, To Mar. 2019Life and Medical SciencesSpring, 工学研究科
- From Apr. 2018, To Mar. 2019Life and Medical Sciences, Adv.Spring, 工学研究科
- From Apr. 2019, To Mar. 2020Chemical BiologyFall, 工学部
- From Apr. 2019, To Mar. 2020Life and Medical SciencesSpring, 工学研究科
- From Apr. 2019, To Mar. 2020Life and Medical Sciences, Adv.Spring, 工学研究科
- From Apr. 2020, To Mar. 2021ILAS Seminar :Seminar on Developmental Biology and Regenerative MedicineSpring, 全学共通科目
- From Apr. 2020, To Mar. 2021Chemical BiologyFall, 工学部
- From Apr. 2020, To Mar. 2021Life and Medical SciencesSpring, 工学研究科
- From Apr. 2020, To Mar. 2021Life and Medical Sciences, Adv.Spring, 工学研究科
- From Apr. 2021, To Mar. 2022Chemical BiologyFall, 工学部
- From Apr. 2021, To Mar. 2022Life and Medical SciencesSpring, 工学研究科
- From Apr. 2021, To Mar. 2022Life and Medical Sciences, Adv.Spring, 工学研究科
