Basic Information

Faculty

• 医学部

Academic Degree

• Master of Pharmaceutical Sciences(Kyoto University)
• Doctor of Pharmaceutical Sciences(Kyoto University)

Academic Resume (Graduate Schools)

• Kyoto University, Graduate School of Pharmaceutical Sciences, 修了
• Kyoto University, Graduate School of Pharmaceutical Sciences, 修了

Academic Resume (Undergraduate School/Majors)

• Kyoto University, Faculty of Pharmaceutical Sciences, 卒業

Research History

• From Apr. 2019, To Mar. 2023

  Kyoto University, 大学院医学研究科 人間健康科学系専攻, 准教授
• From Apr. 2022, To Present

  京都大学創発PI
• From Jul. 2016, To Present

  University of Tsukuba, 准教授（兼任、非常勤）
• From Nov. 2017, To Mar. 2019

  Kyoto University, Graduate School of Pharmaceutical Sciences, 特定研究員
• From Nov. 2017, To Mar. 2019

  Kyoto University, 学際融合教育研究推進センター, 特任講師
• From Jul. 2014, To Oct. 2017

  （国） 産業技術総合研究所, 招聘研究員
• From Oct. 2011, To Jun. 2014

  Sanford-Burnham Medical Research Institute, 研究員
• From Apr. 2010, To Mar. 2013

  日本学術振興会, 特別研究員PD
• From Apr. 2008, To Sep. 2011

  Ritsumeikan University, 糖鎖工学研究センター, 研究員

ID,URL

• J-Global ID

  201701017679036930

Website(s) (URL(s))

• http://oka-lab.hs.med.kyoto-u.ac.jp/index.html

researchmap URL

• https://researchmap.jp/zmdgrs

Research

Research Topics, Overview of the research

• Research Topics

  I am working on three main projects: isolation of glycomimetic peptides by phage library screening, development of anti-cancer therapeutics with tumor targeting peptides, development of biomarkers for autoimmune diseases.

• Overview of the research

  In phage display system, random peptides and proteins are displayed on the surface of phage to obtain molecules that bind to target molecules. In our laboratory, we developed a system that combines phage display and next-generation DNA sequencing technology. This allows for global analysis of millions of sequences at one time. Using this technology, we are developing new diagnostics and treatments for intractable diseases such as cancer, allergy and autoimmune diseases. In addition, although carbohydrates are apparently involved in the onset of various diseases, most of the detailed pathogenesis have not been elucidated yet. In our laboratory, we are trying to control carbohydrate-associated diseases using glycomimetic peptides.

Research Interests

• 自己免疫疾患
• 悪性腫瘍標的ペプチド
• ファージディスプレイ
• 糖鎖生物学

Research Areas

• Life sciences, Molecular biology
• Life sciences, Pharmaceuticals - chemistry and drug development
• Nanotechnology/Materials, Chemical biology

Papers

• Annexin A1‐Targeted d‐Peptide‐Monomethyl Auristatin E Conjugate Enhanced Antitumor Effect of Monomethyl Auristatin E for Chemotherapy of Prostate Cancer

  Kai Ozaki; Tohru Yoneyama; Yuka Kubota; Mihoko Sutoh Yoneyama; Motohiro Nonaka; Tomonori Suzuki; Ryuma Tanaka; Chikara Ohyama; Shingo Hatakeyama

  The Prostate, 06 Jul. 2025

  
• Three glutamic acid residues in the cytoplasmic N-terminal tail of long-form GlcAT-P define Golgi-to-ER trafficking.

  Ayaka Okada; Risa Harui; Tomonari Ishida; Katsuaki Higashi; Motohiro Nonaka; Shogo Oka; Jyoji Morise

  Journal of biochemistry, 09 Jun. 2025

  
• Generating a mirror-image monobody targeting MCP-1 via TRAP display and chemical protein synthesis.

  Gosuke Hayashi; Toshinori Naito; Sayaka Miura; Naoya Iwamoto; Yusuke Usui; Mika Bando-Shimizu; Sae Suzuki; Katsuaki Higashi; Motohiro Nonaka; Shinya Oishi; Hiroshi Murakami

  Nature communications, 23 Dec. 2024

  
• Assay method for the lectin activity of mannan-binding protein

  Katsuaki Higashi; Motohiro Nonaka; Nobuko Kawasaki; Toshisuke Kawasaki

  2021

  
• Isolation of mannan-binding protein from human serum (plasma)

  Katsuaki Higashi; Motohiro Nonaka; Nobuko Kawasaki; Toshisuke Kawasaki

  2021

  
• High-affinity mirror-image monobody targeting MCP-1 generated via TRAP display and chemical protein synthesis

  Hiroshi Murakami; Gosuke Hayashi; Toshinori Naito; Sayaka Miura; Naoya Iwamoto; Yusuke Usui; Motohiro Nonaka; Shinya Oishi

  25 Apr. 2024

  
• Chemical Synthesis of Interleukin-6 for Mirror-Image Screening.

  Keisuke Aoki; Kayuu Maeda; Shinsuke Inuki; Hiroaki Ohno; Motohiro Nonaka; Shinya Oishi

  Bioconjugate chemistry, 21 Aug. 2024

  
• Engineering a Low-Immunogenic Mirror-Image VHH against Vascular Endothelial Growth Factor.

  Keisuke Aoki; Katsuaki Higashi; Sakiho Oda; Asako Manabe; Kayuu Maeda; Jyoji Morise; Shogo Oka; Shinsuke Inuki; Hiroaki Ohno; Shinya Oishi; Motohiro Nonaka

  ACS chemical biology, 17 May 2024

  
• Construction of a T7 phage random peptide library by combining seamless cloning with in vitro translation.

  Katsuaki Higashi; Sakiho Oda; Mai Fujii; Fumiya Nishida; Hayato Matsumoto; Jyoji Morise; Shogo Oka; Motohiro Nonaka

  Journal of biochemistry, 20 Dec. 2023

  
• Mirror-Image Single-Domain Antibody for a Novel Nonimmunogenic Drug Scaffold.

  Keisuke Aoki; Asako Manabe; Hiroyuki Kimura; Yohei Katoh; Shinsuke Inuki; Hiroaki Ohno; Motohiro Nonaka; Shinya Oishi

  Bioconjugate chemistry, 15 Nov. 2023

  
• Design and Synthesis of Monobody Variants with Low Immunogenicity.

  Naoya Iwamoto; Yukino Sato; Asako Manabe; Shinsuke Inuki; Hiroaki Ohno; Motohiro Nonaka; Shinya Oishi

  ACS medicinal chemistry letters, 09 Nov. 2023

  
• 【泌尿器科の未来を拓く基礎研究】次世代高精度放射線治療 分子標的ホウ素中性子捕捉療法の開発

  米山 徹; 畠山 真吾; 米山 美穂子; 飛澤 悠葵; 野中 元裕; 鈴木 実; 八戸 慎吾; 大山 力

  泌尿器科, Apr. 2022

  
• Efficient antigen delivery by dendritic cell-targeting peptide via nucleolin confers superior vaccine effects in mice.

  Teppei Matsuda; Kazuki Misato; Shigeyuki Tamiya; Yasuhiro Akeda; Ikuhiko Nakase; Etsushi Kuroda; Shokichi Takahama; Motohiro Nonaka; Takuya Yamamoto; Michiko N Fukuda; Yasuo Yoshioka

  iScience, 18 Nov. 2022

  
• Characterization of novel antibodies that recognize sialylated keratan sulfate and lacto-N-fucopentaose I on human induced pluripotent cells: comparison with existing antibodies

  Hiromi Nakao; Tomoko Yamaguchi; Kenji Kawabata; Katsuaki Higashi; Motohiro Nonaka; Makoto Tsuiji; Yuko Nagai; Hidenao Toyoda; Yoshiki Yamaguchi; Nobuko Kawasaki; Toshisuke Kawasaki

  Glycobiology, 14 Nov. 2022, Peer-reviewed

  
• Correction to: Tumor vasculature-targeted 10B delivery by an Annexin A1-binding peptide boosts effects of boron neutron capture therapy.

  Tohru Yoneyama; Shingo Hatakeyama; Mihoko Sutoh Yoneyama; Taku Yoshiya; Tsuyoshi Uemura; Takehiro Ishizu; Minoru Suzuki; Shingo Hachinohe; Shintaro Ishiyama; Motohiro Nonaka; Michiko N Fukuda; Chikara Ohyama

  BMC cancer, 29 Jan. 2021, Peer-reviewed

  
• Tumor vasculature-targeted 10B delivery by an Annexin A1-binding peptide boosts effects of boron neutron capture therapy.

  Tohru Yoneyama; Shingo Hatakeyama; Mihoko Sutoh Yoneyama; Taku Yoshiya; Tsuyoshi Uemura; Takehiro Ishizu; Minoru Suzuki; Shingo Hachinohe; Shintaro Ishiyama; Motohiro Nonaka; Michiko N Fukuda; Chikara Ohyama

  BMC cancer, 15 Jan. 2021, Peer-reviewed

  
• Development of an orally-administrable tumor vasculature-targeting therapeutic using annexin A1-binding D-peptides.

  Motohiro Nonaka; Hideaki Mabashi-Asazuma; Donald L Jarvis; Kazuhiko Yamasaki; Tomoya O Akama; Masato Nagaoka; Toshio Sasai; Itsuko Kimura-Takagi; Yoichi Suwa; Takashi Yaegashi; Chun-Teng Huang; Chizuko Nishizawa-Harada; Michiko N Fukuda

  PloS one, 2021, Peer-reviewed

  
• Overcoming the blood-brain barrier by Annexin A1-binding peptide to target brain tumours.

  Motohiro Nonaka; Misa Suzuki-Anekoji; Jun Nakayama; Hideaki Mabashi-Asazuma; Donald L Jarvis; Jiunn-Chern Yeh; Kazuhiko Yamasaki; Tomoya O Akama; Chun-Teng Huang; Alexandre Rosa Campos; Masato Nagaoka; Toshio Sasai; Itsuko Kimura-Takagi; Yoichi Suwa; Takashi Yaegashi; Toshiaki K Shibata; Kazuhiro Sugihara; Chizuko Nishizawa-Harada; Minoru Fukuda; Michiko N Fukuda

  British journal of cancer, Nov. 2020, Peer-reviewed

  
• Distinct Cell Surface Expression Patterns of N-Glycosylation Site Mutants of AMPA-Type Glutamate Receptor under the Homo-Oligomeric Expression Conditions.

  Jyoji Morise; Saki Yamamoto; Ryosuke Midorikawa; Kogo Takamiya; Motohiro Nonaka; Hiromu Takematsu; Shogo Oka

  International journal of molecular sciences, 19 Jul. 2020, Peer-reviewed

  
• Glycan-Dependent and -Independent Dual Recognition between DC-SIGN and Type II Serine Protease MSPL/TMPRSS13 in Colorectal Cancer Cells

  Motohiro Nonaka; Shogo Matsumoto; Bruce Yong Ma; Hiroshi Kido; Nana Kawasaki; Nobuko Kawasaki; Toshisuke Kawasaki

  Applied Sciences, 13 Apr. 2020, Peer-reviewed

  
• Glycoengineering

  Yasuhiro Kajihara; Kenji Yamamoto; Mitsuo Satoh; Shino Manabe; Tatsuya Oda; Osamu Shimomura; Hiroaki Tateno; Jun Hirabayashi; Kazuo Sakurai; Shuji Miyagawa; Katsunori Tanaka; Michiko N. Fukuda; Motohiro Nonaka

  Glycoscience: Basic Science to Applications: Insights from the Japan Consortium for Glycobiology and Glycotechnology (JCGG), 01 Jan. 2019

  
• Function of the glycosyltransferase GnT-V in colitis.

  Motohiro Nonaka

  Journal of gastroenterology, Apr. 2016, Invited

  
• A Cytotoxic Antibody Recognizing Lacto-N-fucopentaose I (LNFP I) on Human Induced Pluripotent Stem (hiPS) Cells.

  Shogo Matsumoto; Hiromi Nakao; Keiko Kawabe; Motohiro Nonaka; Hidenao Toyoda; Yuto Takishima; Kenji Kawabata; Tomoko Yamaguchi; Miho K Furue; Takao Taki; Takeshi Okumura; Yuzo Yamazaki; Shuuichi Nakaya; Nobuko Kawasaki; Toshisuke Kawasaki

  The Journal of biological chemistry, 14 Aug. 2015, Peer-reviewed

  
• Mannan-Binding Protein (Mbp)-Ligand Glycans: Novel Tissue Marker for Colorectal Carcinomas

  Toshisuke Kawasaki; Motohiro Nonaka; Nobuko Kawasaki

  Glycoscience: Biology and Medicine, 01 Jan. 2015, Peer-reviewed

  
• Carbohydrate sequence of the prostate cancer-associated antigen F77 assigned by a mucin O-glycome designer array.

  Chao Gao; Yan Liu; Hongtao Zhang; Yibing Zhang; Michiko N Fukuda; Angelina S Palma; Radoslaw P Kozak; Robert A Childs; Motohiro Nonaka; Zhen Li; Don L Siegel; Peter Hanfland; Donna M Peehl; Wengang Chai; Mark I Greene; Ten Feizi

  The Journal of biological chemistry, 06 Jun. 2014, Peer-reviewed

  
• Determination of carbohydrate structure recognized by prostate-specific F77 monoclonal antibody through expression analysis of glycosyltransferase genes.

  Motohiro Nonaka; Michiko N Fukuda; Chao Gao; Zhen Li; Hongtao Zhang; Mark I Greene; Donna M Peehl; Ten Feizi; Minoru Fukuda

  The Journal of biological chemistry, 06 Jun. 2014, Peer-reviewed

  
• Synthetic di-sulfated iduronic acid attenuates asthmatic response by blocking T-cell recruitment to inflammatory sites.

  Motohiro Nonaka; Xingfeng Bao; Fumiko Matsumura; Sebastian Götze; Jeyakumar Kandasamy; Andrew Kononov; David H Broide; Jun Nakayama; Peter H Seeberger; Minoru Fukuda

  Proceedings of the National Academy of Sciences of the United States of America, 03 Jun. 2014, Peer-reviewed

  
• Mannan-binding protein, a C-type serum lectin, recognizes primary colorectal carcinomas through tumor-associated Lewis glycans.

  Motohiro Nonaka; Hirotsugu Imaeda; Shogo Matsumoto; Bruce Yong Ma; Nobuko Kawasaki; Eiji Mekata; Akira Andoh; Yasuharu Saito; Tohru Tani; Yoshihide Fujiyama; Toshisuke Kawasaki

  Journal of immunology (Baltimore, Md. : 1950), 01 Feb. 2014, Peer-reviewed

  
• Functional assay using lectin gene targeting technologies (over-expression).

  Motohiro Nonaka; Toshisuke Kawasaki

  Methods in molecular biology (Clifton, N.J.), 2014

  
• A novel antibody for human induced pluripotent stem cells and embryonic stem cells recognizes a type of keratan sulfate lacking oversulfated structures.

  Keiko Kawabe; Daiki Tateyama; Hidenao Toyoda; Nana Kawasaki; Noritaka Hashii; Hiromi Nakao; Shogo Matsumoto; Motohiro Nonaka; Hiroko Matsumura; Yoshinori Hirose; Ayaha Morita; Madoka Katayama; Makoto Sakuma; Nobuko Kawasaki; Miho Kusuda Furue; Toshisuke Kawasaki

  Glycobiology, Mar. 2013, Peer-reviewed

  
• Galectin-1 for neuroprotection?

  Motohiro Nonaka; Minoru Fukuda

  Immunity, 24 Aug. 2012, Invited

  
• Dendritic cell-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) recognizes a novel ligand, Mac-2-binding protein, characteristically expressed on human colorectal carcinomas.

  Motohiro Nonaka; Bruce Yong Ma; Hirotsugu Imaeda; Keiko Kawabe; Nobuko Kawasaki; Keiko Hodohara; Nana Kawasaki; Akira Andoh; Yoshihide Fujiyama; Toshisuke Kawasaki

  The Journal of biological chemistry, 24 Jun. 2011, Peer-reviewed

  
• Characterization of the interaction between serum mannan-binding protein and nucleic acid ligands.

  Natsuko Nakamura; Motohiro Nonaka; Bruce Yong Ma; Shogo Matsumoto; Nobuko Kawasaki; Shinji Asano; Toshisuke Kawasaki

  Journal of leukocyte biology, Sep. 2009, Peer-reviewed

  
• The lectin Jacalin induces human B-lymphocyte apoptosis through glycosylation-dependent interaction with CD45.

  Bruce Yong Ma; Kaori Yoshida; Makoto Baba; Motohiro Nonaka; Shogo Matsumoto; Nobuko Kawasaki; Shinji Asano; Toshisuke Kawasaki

  Immunology, Aug. 2009, Peer-reviewed

  
• Colorectal carcinoma-associated carbohydrate recognition tumor-immunological regulation by C-type lectin DC-SIGN

  Motohiro Nonaka; Yong Ma Bruce; Toshisuke Kaswasaki

  Trends in Glycoscience and Glycotechnology, Jul. 2009, Peer-reviewed

  
• Glycosylation-dependent interactions of C-type lectin DC-SIGN with colorectal tumor-associated Lewis glycans impair the function and differentiation of monocyte-derived dendritic cells.

  Motohiro Nonaka; Bruce Yong Ma; Ryuuya Murai; Natsuko Nakamura; Makoto Baba; Nobuko Kawasaki; Keiko Hodohara; Shinji Asano; Toshisuke Kawasaki

  Journal of immunology (Baltimore, Md. : 1950), 01 Mar. 2008, Peer-reviewed

  
• LPS suppresses expression of asialoglycoprotein-binding protein through TLR4 in thioglycolate-elicited peritoneal macrophages.

  Bruce Yong Ma; Mio Kaihama; Motohiro Nonaka; Shogo Oka; Nobuko Kawasaki; Toshisuke Kawasaki

  Glycoconjugate journal, Jul. 2007, Peer-reviewed

  
• Subcellular localization and physiological significance of intracellular mannan-binding protein.

  Motohiro Nonaka; Bruce Yong Ma; Misato Ohtani; Akitsugu Yamamoto; Masayuki Murata; Kiichiro Totani; Yukishige Ito; Keiko Miwa; Wataru Nogami; Nobuko Kawasaki; Toshisuke Kawasaki

  The Journal of biological chemistry, 15 Jun. 2007, Peer-reviewed

  
• Isolation, cloning, and characterization of a novel phosphomannan-binding lectin from porcine serum.

  Bruce Yong Ma; Natsuko Nakamura; Vladimir Dlabac; Haruna Naito; Shinsuke Yamaguchi; Makiko Ishikawa; Motohiro Nonaka; Masaji Ishiguro; Nobuko Kawasaki; Shogo Oka; Toshisuke Kawasaki

  The Journal of biological chemistry, 27 Apr. 2007, Peer-reviewed

  
• Glycosylation-dependent interaction of Jacalin with CD45 induces T lymphocyte activation and Th1/Th2 cytokine secretion.

  Makoto Baba; Bruce Yong Ma; Motohiro Nonaka; Yukari Matsuishi; Makoto Hirano; Natsuko Nakamura; Nana Kawasaki; Nobuko Kawasaki; Toshisuke Kawasaki

  Journal of leukocyte biology, Apr. 2007, Peer-reviewed

  

Misc.

• T7ファージによるVHH抗体提示ライブラリーの構築と鏡像VHH抗体の開発

  前田佳夕; 青木啓輔; 大野浩章; 森瀬譲二; 岡昌吾; 大石真也; 野中元裕

  日本生化学会大会(Web), 2023

  
• NODマウスを用いた自己抗原エピトープ模倣ペプチドの取得

  松本隼杜; 東克暁; 森瀬譲二; 岡昌吾; 野中元裕

  日本生化学会大会(Web), 2023

  
• T7ファージライブラリーの新規作製法の開発

  東克暁; 小田幸穂; 森瀬譲二; 岡昌吾; 野中元裕

  日本生化学会大会(Web), 2023

  
• Ferチロシンキナーゼは前立腺癌細胞のα-dystroglycanのラミニン結合糖鎖発現を介して細胞遊走能を制御する(Fer tyrosine kinase regulates prostate cancer cell motility through alpha-dystroglycan glycosylation)

  米山 徹; 飛澤 悠葵; 野中 元裕; 大山 力; Courtneidge Sara; 福田 穰

  日本生化学会大会プログラム・講演要旨集, Dec. 2012

  
• Intracellular mannan-binding protein and its physiological significance

  M Nonaka; BY Ma; M Ohtani; K Miwa; A Yamamoto; M Murata; Y Ito; N Kawasaki; S Oka; T Kawasaki

  GLYCOBIOLOGY, Nov. 2005

  
• Carbohydrate mimetic peptides as anti-cancer therapeutics

  Motohiro Nonaka

  Trends in Glycoscience and Glycotechnology, 2021

  
• 糖鎖模倣ペプチドを用いた悪性脳腫瘍治療

  野中元裕

  日本糖質学会年会要旨集, 2019

  
• アレルギー疾患の化学療法を目指したファージディスプレイ戦略

  野中元裕

  天然薬物の開発と応用シンポジウム講演要旨集, 2018

  
• 糖鎖模倣ペプチドによる悪性脳腫瘍治療薬の開発

  福田道子; 野中元裕

  技術情報協会, 2017

  
• Expression and function of poly-n-acetyllactosamine type glycans in cancer

  Motohiro Nonaka; Minoru Fukuda

  Glycosignals in Cancer: Mechanisms of Malignant Phenotypes, 01 Jan. 2016

  
• Characterization of the interaction between N-terminal annexin A1 residue and tumor-targeting carbohydrate-mimetic IF7 peptide

  Motohiro Nonaka; Toshio Sasai; Masato Nagaoka; Michiko N. Fukuda

  GLYCOBIOLOGY, Nov. 2015

  
• Laminin binding glycan depletion on alpha-dystroglycan in prostate cancer cells promotes epithelial-mesenchymal transition and enhances tumor formation

  Tohru Yoneyama; Shingo Hatakeyama; Yuki Tobisawa; Motohiro Nonaka; Chikara Ohyama; Minoru Fukuda

  GLYCOBIOLOGY, Nov. 2014

  
• Targeted drug delivery to brain tumor vasculature by carbohydrate mimetic peptide in mouse glioma model

  Misa Suzuki-Anekoji; Jiunn-Chern Yeh; Masatomo Kawakubo; Motohiro Nonaka; Toshiaki K. Shibata; Kazuhiro Sugihara; Jun Nakayama; Minoru Fukuda; Michiko N. Fukuda

  GLYCOBIOLOGY, Nov. 2014

  
• Overcoming blood-brain barrier by targeted drug delivery to brain tumor vasculature with carbohydrate mimetic peptide in mouse glioma model

  Misa Suzuki-Anekoji; Jiunn-Chern Yeh; Motohiro Nonaka; Toshiaki Shibata; Jun Nakayama; Tomoya Akama; Kazuhiro Sugihara; Minoru Fukuda; Michiko Fukuda

  FASEB JOURNAL, Apr. 2014

  
• Role of heparan sulfate in intestinal normal and cancer stem cells

  Motohiro Nonaka; Jun Nakayama; Minoru Fukuda

  FASEB JOURNAL, Apr. 2014

  
• Role of soluble heparan sulfate proteoglycans in sepsis

  Motohiro Nonaka; Jamey Marth; Masaya Yamaguchi; Douglas Heithoff; Jeffrey Smith; Qiongyu Chen; Dzung Le; Michael Mahan; Victor Nizet; Minoru Fukuda

  GLYCOBIOLOGY, Nov. 2013

  
• Fer tyrosine kinase regulates breast and prostate cancer cell motility through alpha-dystroglycan glycosylation

  Tohru Yoneyama; Motohiro Nonaka; Chikara Ohyama; Sara Courtneidge; Minoru Fukuda

  GLYCOBIOLOGY, Nov. 2012

  
• Fer tyrosine kinase down-regulates alpha-dystroglycan glycosylation in C2C12 myotube cells

  Motohiro Nonaka; Tohru Yoneyama; Misa Suzuki-Anekoji; Minoru Fukuda

  GLYCOBIOLOGY, Nov. 2012

  
• Mac-2BP Expressed on Human Colon Carcinomas is a Novel Ligand for DC-Sign

  Motohiro Nonaka; Bruce Yong Ma; Shogo Matsumoto; Keiko Yamaguchi; Nobuko Kawasaki; Toshisuke Kawasaki

  GLYCOBIOLOGY, Nov. 2010

  
• Interaction of Serum Mannan-Binding Protein and Nucleic Acids

  Motohiro Nonaka; Bruce Y. Ma; Shogo Matsumoto; Nobuko Kawasaki; Toshisuke Kawasaki

  GLYCOBIOLOGY, Nov. 2009

  
• 【ますます重要になる細胞周辺環境(細胞ニッチ)の最新科学技術 細胞の生存、増殖、機能のコントロールから創薬研究、再生医療まで】 細胞周辺環境のための生物医学 糖鎖認識レセプターによる糖鎖シグナルの制御

  野中 元裕; Ma Bruce Yong; 川嵜 敏祐

  遺伝子医学MOOK, Aug. 2009

  
• Functional Recognition of Colorectal Tumor-associated Lewis Glycans by C-type Lectin DC-SIGN

  Motohiro Nonaka; Bruce Yong Ma; Nobuko Kawasaki; Toshisuke Kawasaki

  GLYCOBIOLOGY, Nov. 2008

  
• Carbohydrate recognition and immune regulation by dendritic-cell lection

  野中 元裕; Yong Ma Bruce; 川嵜 敏祐

  Protein, nucleic acid and enzyme, Sep. 2008

  
• Functional implication of intracellular mannan-binding protein

  M Nonaka; BY Ma; M Ohtani; K Miwa; T Nakagawa; S Oka; N Kawasaki; A Yamamoto; T Kawasaki

  GLYCOBIOLOGY, Nov. 2004

  
• 糖鎖ミメティクスを用いた、がんの治療法研究

  野中 元裕

  Trends in Glycoscience and Glycotechnology, May 2021

  
• 【IBD免疫の更なる理解をめざして!】IBD病態理解に役立つ糖鎖機能の基礎

  野中 元裕

  IBD Research, Mar. 2017

  

Presentations

• Identification of binding peptides against IgE from human myeloma U266 cells

  M. Nonaka; M.N. Fukuda; H. Kakeya

  The 9th Japan-Korea Chemical Biology Symposium (Incheon, Korea), 2018

  
• Drug delivery to malignant brain tumor by a peptide specific to Annexin A1

  M. Nonaka; H. Kakeya; M.N. Fukuda

  30th EORTC-NCI-AACR Symposium (Dublin, Ireland), 2018

  
• アレルギー疾患の化学療法を目指したファージディスプレイ戦略（奨励研究賞受賞講演）

  野中元裕

  日本薬学会生薬天然物部会, 2018

  
• 糖鎖模倣ペプチドによる脳腫瘍治療

  野中元裕

  第14回臨床糖鎖研究会, 2018

  
• Identification of carbohydrate-mimetic D-amino acid peptides by peptide-display library screening as chemotherapy for malignant brain tumors

  M. Nonaka; M. Suzuki-Anekoji; O. Akama; J. Nakayama; M.N. Fukuda

  Society for Glycobiology, annual meeting (Portland, USA), 2017

  
• 悪性腫瘍血管表面に特異的に結合するペプチドによる癌治療

  野中元裕; 福田道子

  慶応大第二回橋渡し研究加速ネットワークプログラムシンポジウム, 2017

  
• 糖鎖模倣ペプチドを用いた悪性脳腫瘍の治療戦略

  野中元裕; 赤間智也; 中山淳; 福田道子

  第36回日本糖質学会年会, 2017

  
• 悪性腫瘍標的ペプチドによる脳腫瘍治療

  野中元裕; 福田道子

  第76回日本癌学会学術総会, 2017

  
• 血管脳関門突破を可能にするペプチド創薬: 脳腫瘍抗がん剤への挑戦

  野中元裕; 鈴木-姉小路美沙; 福田道子

  第89回日本薬理学会年会, 2016

  
• ヒトiPS細胞表面のLacto‐N‐fucopentaose 1を認識する細胞傷害性マーカー抗体

  川嵜敏祐; 松本尚悟; 中尾広美; 野中元裕; 豊田英尚; 川端健二; 瀧孝雄; 川嵜伸子

  日本糖質学会年会要旨集, 01 Jul. 2015

  
• Characterization of the interaction between N-terminal annexin A1 residue and tumor-targeting carbohydrate-mimetic IF7 peptide.

  M. Nonaka; T. Sasai; M Nagaoka; N. Fukuda

  Society for Glycobiology, annual meeting (San Francisco, USA), 2015

  
• 糖鎖模倣ペプチドによる悪性腫瘍血管標的抗癌剤

  福田道子; 鈴木-姉小路美沙; 野中元裕

  第34回日本糖質学会年会, 2015

  
• がん研究と癌治療薬における糖鎖模倣ペプチド

  福田道子; 鈴木-姉小路美沙; 野中元裕

  第74回日本癌学会学術総会, 2015

  
• Role of Heparan Sulfate in Intestinal Normal and Cancer Stem Cells

  M. Nonaka; J. Nakayama; M. Fukuda

  Experimental Biology (San Diego, USA), 2014

  
• Overcoming blood-brain barrier by targeted drug delivery to brain tumor vasculature with carbohydrate mimetic peptide in mouse glioma model

  M. Anekoji; J. Yeh; M Nonaka; T. K. Shibata; J. Nakayama; T. Akama; K. Sugihara; M. Fukuda; M. N. Fukuda

  Experimental Biology (San Diego, USA), 2014

  
• Targeted drug delivery to brain tumor vasculature by carbohydrate mimetic peptide in mouse glioma model.

  M. Anekoji; J. Yeh; M. Kawakubo; M Nonaka; T. K. Shibata; K. Sugihara; J. Nakayama; M. Fukuda; M. N. Fukuda

  Society for Glycobiology and the Japanese Society of Carbohydrate Research 2014 Joint Annual Meeting (Hawaii, USA), 2014

  
• Distinct roles of heparan sulfate proteoglycans in sepsis

  M. Nonaka; M. Yamaguchi; Q. Chen; V. Nizet; D. Le; M. Fukuda

  17th Annual San Diego Glycobiology Symposium (San Diego, USA), 2014

  
• ヒトiPS/ESマーカーとしての新規糖鎖認識抗体

  松本尚悟; 中尾広美; 野中元裕; 川端健二; 古江(楠田)美保; 滝嶌佑人; 豊田英尚; 川嵜伸子; 川嵜敏祐

  日本生化学会大会(Web), Sep. 2013

  
• マンナン結合タンパク質(MBP)はがん関連糖鎖抗原を介して結腸がん細胞を特異的に認識する

  川嵜敏祐; 野中元裕; 今枝広丞; YONG Ma Bruce; 川嵜伸子; 谷徹; 安藤朗; 藤山佳秀

  補体シンポジウム講演集, Jul. 2013

  
• Role of soluble heparan sulfate proteoglycans in sepsis.

  M. Nonaka; J. Marth; M. Yamaguchi; D. Heithoff; Q. Chen; D. Le; M. Mahan; V. Nizet; M. Fukuda

  Society for Glycobiology, annual meeting (Florida, USA), 2013

  
• Involvement of soluble heparan sulfate proteoglycan in coagulation system during sepsis

  M. Nonaka; M. Yamaguchi; Q. Chen; V. Nizet; D. Le; M. Fukuda

  16th Annual San Diego Glycobiology Symposium(San Diego, USA), 2013

  
• チロシンキナーゼFerによる糖鎖調節と癌遊走促進機構

  野中元裕

  第32回日本糖質学会年会, 2013

  
• Ferチロシンキナーゼは前立腺癌細胞のα-dystroglycanのラミニン結合糖鎖発現を介して細胞遊走能を制御する(Fer tyrosine kinase regulates prostate cancer cell motility through alpha-dystroglycan glycosylation)

  米山 徹; 飛澤 悠葵; 野中 元裕; 大山 力; Courtneidge Sara; 福田 穰

  日本生化学会大会プログラム・講演要旨集, Dec. 2012

  
• ヒトiPS細胞上のケラタン硫酸鎖を認識する新規単クローン抗体の性質

  松本尚悟; 中尾広美; 河邊圭子; 館山大揮; 廣瀬佳則; 森田彩葉; 野中元裕; 川崎ナナ; 橋井則貴; 川嵜伸子; 古江(楠田)美保; 豊田英尚; 川嵜敏祐

  日本糖質学会年会要旨集, 31 Aug. 2012

  
• Fer tyrosine kinase regulates breast and prostate cancer cell motility through α-dystroglycan glycosylation.

  T. Yoneyama; ○M. Nonaka; C. Ohyama; S. Courtneidge; M. Fukuda

  Society for Glycobiology, annual meeting (San Diego, USA), 2012

  
• Fer tyrosine kinase downregulates α-dystroglycan glycosylation in C2C12 myotube cells.

  M. Nonaka; T. Yoneyama; M. Anekoji; M. Fukuda

  Society for Glycobiology, annual meeting (San Diego, USA), 2012

  
• Colorectal carcinoma cells induce dysfunction of dendritic cells through glycosylation-dependent interactions between tumor-associated glycans and DC-SIGN.

  M. Nonaka; B. Y. Ma; N. Kawasaki; T. Kawasaki

  98th Indian Science Congress (Chennai, India), 2011

  
• C-type lectin DC-SIGN interacts with Mac-2 binding protein expressed on colorectal carcinoma through tumor-associated Lewis glycans

  M. Nonaka; B. Y. Ma; N. Kawasaki; T. Kawasaki

  16th European Carbohydrate Symposium, (Sorrent, Italy), 2011

  
• ヒト大腸がん組織におけるマンナン結合タンパク質リガンドの発現

  野中元裕; 今枝広丞; 河邊圭子; 川嵜伸子; 安藤朗; 藤山佳秀; 谷徹; 川嵜敏祐

  第30回日本糖質学会年会, 2011

  
• Mac-2BP expressed on human colon carcinomas is a novel ligand for DC-SIGN

  M. Nonaka; B. Y. Ma; S. Matsumoto; K. Yamaguchi; N. Kawasaki; T. Kawasaki

  Society for Glycobiology, annual meeting (Florida, USA), 2010

  
• C-Type Lectin DC-SIGN Recognizes Its Novel Ligand Mac-2 Binding Protein Through Colorectal Cancer-Associated Glycans

  M. Nonaka; B. Y. Ma; S. Matsumoto; N. Kawasaki; T. Kawasaki

  25th International Carbohydrate Symposium (Makuhari, Japan), 2010

  
• C-Type lectin DC-SIGN interacts with Mac-2BP expressed on human colon tumors

  野中元裕; Ma Bruce Yong; 山口圭子; 川嵜伸子; 川嵜敏祐

  第33回日本分子生物学会年会・第83回日本生化学会大会合同大会, 2010

  
• CD26/DPPIVの糖鎖構造と酵素活性に関する研究

  山口圭子; 大坪和明; 荒川健司; KHOO Kay‐Hooi; 川崎ナナ; 中尾広美; 野中元裕; MA Bruce Yong; 川嵜伸子; 川嵜敏祐

  生化学, 25 Sep. 2009

  
• Characteristic recognition and biological significance of the interaction between serum mannan-binding protein and nucleic acids

  M. Nonaka; B. Y. Ma; S. Matsumoto; N. Kawasaki; T. Kawasaki

  21st IUBMB & 12th FAOBMB International Congress of Biochemistry and Molecular Biology (Shanghai, 2009), 2009

  
• Characteristic interaction of serum mannan-binding protein with nucleic acids

  M. Nonaka; B. Y. Ma; S. Matsumoto; N. Kawasaki; T. Kawasaki

  Society for Glycobiology, annual meeting, (San Diego, USA), 2009

  
• 血清型マンナン結合タンパク質による核酸の認識とその意義

  野中元裕; Ma Bruce Yong; 中村奈都子; 松本尚悟; 川嵜伸子; 川嵜敏祐

  第29回日本糖質学会年会, 2009

  
• 血清型マンナン結合タンパク質と核酸の相互作用の解析とその生物学的意義

  野中元裕; Ma Bruce Yong; 松本尚悟; 川嵜伸子; 川嵜敏祐

  第82回日本生化学会大会, 2009

  
• Functional Implications for C-type Lectin DC-SIGN Recognizing Colorectal Tumor-Associated Lewis Glycans

  M. Nonaka; B. Y. Ma; N. Kawasaki; T. Kawasaki

  The 23rd International Lectin Conference (Interlec-23) (Edinburgh, Scotland), 2008

  
• Functional Recognition of Colorectal Tumor-associated Lewis Glycans by C-type Lectin DC-SIGN

  M. Nonaka; B. Y. Ma; N. Kawasaki; T. Kawasaki

  Society for Glycobiology, annual meeting (Fort Worth, USA), 2008

  
• Jacalin-induced diverse immune responses through glycosylation-dependent interaction with CD45 on lymphocytes

  M. Nonaka; B. Y. Ma; N. Kawasaki; T. Kawasaki

  8th Human Disease Glycomics/ Proteome Initiative (HGPI) meeting, (Fort Worth, USA), 2008

  
• CD45を標的とするJacalinによるBリンパ球のアポトーシスの誘導

  松本尚悟; Ma BY; 野中元裕; 吉田香織; 馬場亮人; 川嵜伸子; 浅野真司; 川嵜敏祐

  第28回日本糖質学会年会, 2008

  
• レクチンJacalinによるBリンパ球のアポトーシスの誘導

  Ma BY; 野中元裕; 川嵜敏祐

  第38回日本免疫学会総会・学術集会, 2008

  
• 樹状細胞C型レクチンDC-SIGNによる結腸がん細胞表面糖鎖の認識と腫瘍免疫の調節機構

  野中元裕; Ma BY; 川嵜伸子; 川嵜敏祐

  第31回日本分子生物学会年会、第81回日本生化学会大会合同大会（BMB2008）, 2008

  
• DC-SIGN Binding to Colorectal Carcinoma Induces Dysfunction of Monocyte-Derived Dendritic Cells

  M. Nonaka; B. Y. Ma; R. Murai; N. Kawasaki; T. Kawasaki

  The 27th Sapporo Cancer Seminar International Symposium (Sapporo, Japan), 2007

  
• Glycosylation-Dependent Binding of DC-SIGN to Colorectal Tumor-Associated Glycans Impairs the Function and Maturation of Monocyte-Derived Dendritic Cells

  M. Nonaka; B. Y. Ma; R. Murai; N. Kawasaki; T. Kawasaki

  XIX International Symposium on Glycoconjugates (Cairns, Australia), 2007

  
• DC-SIGNによる結腸がん表面糖鎖の認識とその免疫生物学的意義

  野中元裕; Ma BY; 村井竜也; 川嵜伸子; 川嵜敏祐

  第27回日本糖質学会年会, 2007

  
• Glycosylation-Dependent Interaction of DC-SIGN with Colorectal Carcinoma-associated Glycans Induces Dysfunction of Monocyte-Derived Dendritic Cells

  野中元裕; Ma BY

  第37回日本免疫学会総会・学術集会, 2007

  
• C型レクチンによる核酸認識とその免疫学的意義

  松本尚悟; Ma BY; 中村奈都子; 野中元裕; 川嵜伸子; 浅野真司; 川嵜敏祐

  第30回日本分子生物学会年会、第80回日本生化学会大会合同大会（BMB2007）, 2007

  
• The Physiological Significance of Intracellular Mannan-Binding Protein

  M. Nonaka; B. Y. Ma; M. Ohtani; A. Yamamoto; M. Murata; Y. Ito; N. Kawasaki; S. Oka; T. Kawasaki

  20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress (Kyoto, Japan), 2006

  
• Intracellular Mannan-Binding Protein and its Physiological Significance

  M. Nonaka; B. Y. Ma; M. Ohtani; K. Miwa; A. Yamamoto; M. Murata; Y. Ito; N. Kawasaki; S. Oka; T. Kawasaki

  Society for Glycobiology, annual meeting (Boston, USA), 2005

  
• Subcellular localization of I-MBP and its functional implication

  T. Kawasaki; M. Nonaka; M. Ohtani; A. Ymamamoto; S. Oka; B. Y. Ma

  GLYCO XVIII International Symposium Glyco-conjugates (Firenze, Italy), 2005

  
• I-MBPによる糖タンパク質の品質管理に関する研究

  大谷美里; Ma BY; 野中元裕; 三輪佳子; 山本章嗣; 村田昌之; 川嵜伸子; 岡昌吾; 川嵜敏祐

  第25回日本糖質学会年会, 2005

  
• 細胞内マンナン結合タンパク質とその生理的意義

  Ma BY; 野中元裕; 大谷美里; 山本章嗣; 村田昌之; 三角佳生; 三輪佳子; 川嵜伸子; 岡昌吾; 川嵜敏祐

  第25回日本糖質学会年会, 2005

  
• 新規ブタ血清ホスホマンナン結合タンパク質の補体活性化および糖鎖特異性

  中村奈都子; Ma BY; Dlabac V; 石黒正路; 山口晋右; 石川麻喜子; 野中元裕; 川嵜伸子; 岡昌吾; 川嵜敏祐

  第78回日本生化学会大会, 2005

  
• Functional Implication of the Subcellular Localization of L-MBP

  B. Y. Ma; W. Nogami; M. Ohtani; T. Nakagawa; M. Nonaka; N. Kawasaki; T. Kawasaki

  Interlec 21, 21st International Lectin Meeting (Shounan, Japan), 2004

  
• Functional Implication of Intracellular Mannan-Binding Protein

  M. Nonaka; B. Y. Ma; M. Ohtani; K. Miwa; T. Nakagawa; S. Oka; N. Kawasaki; A. Yamamoto; T. Kawasaki

  US/Japan Glyco 2004-Joint Meeting of the Society for Glycobiology and Japanese Society of Carbohydrate Research (Hawaii, USA), 2004

  
• MBP依存的細胞性細胞障害作用の分子機構

  野中元裕; 中川知明; 三輪佳子; 野上渉; 馬永; 川嵜敏祐

  第53回日本薬学会近畿支部大会, 2003

  

External funds: Kakenhi

• Development of Screening Platform for Mirror-image Antibody-like Scaffolds

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Kyoto Pharmaceutical University

  Shinya Oishi

  From 30 Jul. 2020, To 31 Mar. 2023, Project Closed

  スクリーニング;抗体様分子;鏡像型タンパク質;創薬;モダリティ;ケモカイン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21252/
• The regulatory mechanism of macrophage phagocytosis by secretory hemprotein neudesin

  Grant-in-Aid for Scientific Research (C)

  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related

  Kobe Pharmaceutical University

  Yoshiaki NAKAYAMA

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  赤血球代謝;マクロファージ;サイトカイン;貪食受容体;Neudesin;一酸化窒素;炎症;JAK/STAT1;赤血球;Jak/Stat;貪食;ヘムタンパク質;赤血球貪食

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07060/
• Regulation of immune system by mimetic peptides

  Grant-in-Aid for Scientific Research (C)

  Basic Section 37030:Chemical biology-related

  Kyoto University

  Motohiro Nonaka

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  ファージディスプレイ;自己免疫疾患;自己抗体;エピトープ;ペプチド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K05732/
• Optimization of Endometriosis-Targeted Therapeutic Peptide Using Cynomolgus Monkey

  Grant-in-Aid for Scientific Research (B)

  Basic Section 42040:Laboratory animal science-related

  Azabu University;Shiga University of Medical Science

  Shinichiro Nakamura

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  子宮内膜症;ペプチド療法;カニクイザル;ペプチド創薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02362/
• Development of IgE-producing B-cell targeting peptide to treat pollen allergy

  Grant-in-Aid for Young Scientists (B)

  Kyoto University;National Institute of Advanced Industrial Science and Technology

  Motohiro Nonaka

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  アレルギー;ファージディスプレイ;花粉症;薬学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18917/
• 糖鎖認識受容体による免疫応答の制御機構

  Grant-in-Aid for Scientific Research (C)

  Ritsumeikan University

  MA Bruce Yong;MA BruceYong

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  C型レクチン;糖鎖リガンド;腫瘍免疫;樹状細胞;糖鎖シグナル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21590543/
• Immune regulatory effect of C-type lectin DC-SIGN on colorectal tumors

  Grant-in-Aid for Young Scientists (Start-up)

  Ritsumeikan University

  Motohiro NONAKA

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  樹状細胞;結腸がん;免疫制御;DC-SIGN;MBP;DNA;ファゴサイトーシス;アポトーシス;Jacalin;B細胞;CD45

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20890255/
• Development of mirror-image antibody-like scaffolds and their applications

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related

  Kyoto Pharmaceutical University

  大石 真也

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  鏡像型タンパク質;抗体様分子;医薬品探索;スクリーニング;モダリティ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H02747/
• Development of antibody-mimetic libraries by CDR grafting

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 47:Pharmaceutical sciences and related fields

  Kyoto University

  野中 元裕

  From 30 Jun. 2022, To 31 Mar. 2025, Granted

  Nanobody;抗体;CDR;ファージディスプレイ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19376/
• Development of a low-molecular-weight antibody library and its application in mirror-image screening

  Grant-in-Aid for Scientific Research (B)

  Basic Section 37010:Bio-related chemistry

  Kyoto University

  野中 元裕

  From 01 Apr. 2024, To 31 Mar. 2028, Granted

  ファージディスプレイ;ペプチド;抗体;免疫原性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K01628/
• Development of mirror-image antibody-like scaffolds and their applications

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related

  Kyoto Pharmaceutical University

  大石 真也

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  鏡像型タンパク質;抗体様分子;医薬品探索;スクリーニング;モダリティ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24010/
• Identification of neoantigens promoting inflammaging

  Grant-in-Aid for Challenging Research (Pioneering)

  Medium-sized Section 49:Pathology, infection/immunology, and related fields

  Kyoto University

  茶本 健司

  From 28 Jun. 2024, To 31 Mar. 2027, Granted

  自己免疫;ファージディスプレイ;ネオ抗原

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K21286/
• RNA編集技術を用いたファージ連続進化法の開発

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Kyoto University

  野中 元裕

  From 27 Jun. 2025, To 31 Mar. 2027, Adopted

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K22309/

Education

Teaching subject(s)

• From 01 Apr. 2025, To 31 Mar. 2026

  Fundamental Chemical Experiments

  N308, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Introduction to Human Health Sciences I

  3201, Spring, Faculty of Medicine, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Experimental Practice in Biochemistry

  8008, Fall, Faculty of Medicine, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Clinical Pharmacy and Pharmacology

  3219, Spring, Faculty of Medicine, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Introduction to Human Health Sciences II

  3202, Spring, Faculty of Medicine, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Practice of Clinical Chemistry

  8024, Fall, Faculty of Medicine, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Molecular cell biology training

  8010, Fall, Faculty of Medicine, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Seminar of Molecular Basic Medical Science

  M427, Fall, Graduate School of Medicine, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Lecture of Molecular Basic Medical Science

  M426, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Biochemistry

  8007, Fall, Faculty of Medicine, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Clinical Chemistry II

  8023, Fall, Faculty of Medicine, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Clinical Chemistry I

  8022, Spring, Faculty of Medicine, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Special Seminar of Multidisciplinary Medical Sciences

  M456, Year-long, Graduate School of Medicine, 8
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Seminar of Molecular Basic Medical Science

  D426, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Lecture of Molecular Basic Medical Science

  D425, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Methods in Molecular Basic Medical Science

  M428, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Research of Molecular Basic Medical Science

  D427, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Practice in Biochemistry

  8008, Fall, Faculty of Medicine, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Special Seminar of Multidisciplinary Medical Sciences

  M456, Year-long, Graduate School of Medicine, 8
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Seminar of Molecular Basic Medical Science

  D426, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Lecture of Molecular Basic Medical Science

  D425, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Methods in Molecular Basic Medical Science

  M428, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Research of Molecular Basic Medical Science

  D427, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Fundamental Chemical Experiments

  N308, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Biochemistry and Neutrition

  3221, Spring, Faculty of Medicine, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Molecular cell biology training

  8010, Fall, Faculty of Medicine, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Seminar of Molecular Basic Medical Science

  M427, Fall, Graduate School of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Lecture of Molecular Basic Medical Science

  M426, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Molecule cellular biology

  8009, Fall, Faculty of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Special Seminar of Multidisciplinary Medical Sciences

  M456, Year-long, Graduate School of Medicine, 8
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Seminar of Molecular Basic Medical Science

  D426, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Lecture of Molecular Basic Medical Science

  D425, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Methods in Molecular Basic Medical Science

  M428, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Research of Molecular Basic Medical Science

  D427, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Special Seminar of Multidisciplinary Medical Sciences

  M456, Year-long, Graduate School of Medicine, 8
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Seminar of Molecular Basic Medical Science

  M427, Fall, Graduate School of Medicine, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Lecture of Molecular Basic Medical Science

  D425, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Methods in Molecular Basic Medical Science

  M428, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Seminar of Molecular Basic Medical Science

  D426, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Molecule cellular biology

  8009, Fall, Faculty of Medicine, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Research of Molecular Basic Medical Science

  D427, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Biochemistry and Neutrition

  3221, Spring, Faculty of Medicine, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Molecular cell biology training

  8010, Fall, Faculty of Medicine, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Fundamental Chemical Experiments

  N308, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Lecture of Molecular Basic Medical Science

  M426, Spring, Graduate School of Medicine, 2
• From Apr. 2018, To Mar. 2019

  Pharmaceutical Laboratory 2 : Organic Chemistry

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Molecule cellular biology

  Fall, 医学部（人間健康科学科）
• From Apr. 2019, To Mar. 2020

  Molecular cell biology training

  Fall, 医学部（人間健康科学科）
• From Apr. 2019, To Mar. 2020

  Fundamental Chemical Experiments

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Biochemistry and Neutrition

  Spring, 医学部（人間健康科学科）
• From Apr. 2019, To Mar. 2020

  Pharmaceutical Laboratory 2 : Organic Chemistry

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Molecule cellular biology

  Fall, 医学部（人間健康科学科）
• From Apr. 2020, To Mar. 2021

  Molecular cell biology training

  Fall, 医学部（人間健康科学科）
• From Apr. 2020, To Mar. 2021

  Fundamental Chemical Experiments

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Advanced methods in Basic Laboratory Science

  Year-long, 医学研究科（人間健康科学系専攻）
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Science Seminar

  Fall, 医学研究科（人間健康科学系専攻）
• From Apr. 2020, To Mar. 2021

  Advanced Basic Laboratory Science Research

  Year-long, 医学研究科（人間健康科学系専攻）
• From Apr. 2020, To Mar. 2021

  Advanced Basic Laboratory Science

  Spring, 医学研究科（人間健康科学系専攻）
• From Apr. 2020, To Mar. 2021

  Advanced Basic Laboratory Science

  Year-long, 医学研究科（人間健康科学系専攻）
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Science Seminar

  Year-long, 医学研究科（人間健康科学系専攻）
• From Apr. 2020, To Mar. 2021

  Biochemistry and Neutrition

  Spring, 医学部（人間健康科学科）
• From Apr. 2021, To Mar. 2022

  Advanced Seminar of Molecular Basic Medical Science

  Fall, 医学研究科（人間健康科学系専攻）
• From Apr. 2021, To Mar. 2022

  Advanced Research of Molecular Basic Medical Science

  Year-long, 医学研究科（人間健康科学系専攻）
• From Apr. 2021, To Mar. 2022

  Advanced Lecture of Molecular Basic Medical Science

  Spring, 医学研究科（人間健康科学系専攻）
• From Apr. 2021, To Mar. 2022

  Advanced Lecture of Molecular Basic Medical Science

  Year-long, 医学研究科（人間健康科学系専攻）
• From Apr. 2021, To Mar. 2022

  Advanced Seminar of Molecular Basic Medical Science

  Year-long, 医学研究科（人間健康科学系専攻）
• From Apr. 2021, To Mar. 2022

  Molecule cellular biology

  Fall, 医学部（人間健康科学科）
• From Apr. 2021, To Mar. 2022

  Molecular cell biology training

  Fall, 医学部（人間健康科学科）
• From Apr. 2021, To Mar. 2022

  Fundamental Chemical Experiments

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Biochemistry and Neutrition

  Spring, 医学部（人間健康科学科）
• From Apr. 2021, To Mar. 2022

  Special Seminar of Multidisciplinary Medical Sciences

  Year-long, 医学研究科（人間健康科学系専攻）

Participation in PhD Defense

• Analysis of Molecular Changes and Features in Rat Knee Osteoarthritis Cartilage: Progress From Cellular Changes to Structural Damage

  ZHAO ZIXI, Graduate School of Medicine, Sub-chief Examiner

  24 Mar. 2025

Administration

School management (title, position)

• From 01 Apr. 2025, To 31 Mar. 2026

  国際高等教育院 企画評価専門委員会 化学部会
• From 01 Oct. 2024, To 30 Sep. 2026

  組換えDNA実験安全委員会 委員
• From 01 Jan. 2024, To 31 Dec. 2024

  オープンキャンパス委員会 委員
• From 01 Apr. 2022, To 31 Mar. 2023

  国際高等教育院 企画評価専門委員会 化学部会 委員
• From 01 Apr. 2020, To 31 Mar. 2021

  国際高等教育院 企画評価専門委員会 化学部会 委員
• From 01 Apr. 2021, To 31 Mar. 2022

  国際高等教育院 企画評価専門委員会 化学部会 委員

Faculty management (title, position)

• From 01 Apr. 2025, To 31 Mar. 2027

  病院構内実験排水系管理委員会_委員
• From 01 Apr. 2023, To 31 Mar. 2024

  教務・教育委員会委員
• From 01 Apr. 2021, To 31 Mar. 2023

  病院構内実験排水系管理委員会委員