Basic Information

Email Address

• Email Address

  sekine.shiori.6ykyoto-u.ac.jp

Professional Memberships

• From 2024, To Present

  日本ミトコンドリア学会
• From 2006, To Present

  生化学会
• From 2006, To Present

  分子生物学会
• From Apr. 2026

  日本薬学会

Academic Degree

• 24 Mar. 2011

  東京大学博士（薬学）
• 24 Mar. 2008

  東京大学修士（薬学）

Academic Resume (Graduate Schools)

• 東京大学, 大学院薬学系研究科生命薬学専攻博士課程, 修了
• 東京大学, 大学院薬学系研究科生命薬学専攻修士課程, 修了

Academic Resume (Undergraduate School/Majors)

• 東京大学, 薬学部薬学科, 卒業

High School

• High School

  Oin Senior High School

Research History

• From Apr. 2026, To Present

  Department of Organelle Signaling, Graduate School of Pharmaceutical Sciences, Kyoto University, Professor
• From Oct. 2025, To Mar. 2026

  Department of Organelle Signaling, Graduate School of Pharmaceutical Sciences, Kyoto University, Professor
• From Jul. 2023, To Mar. 2026

  Aging Institute, Department of Cell Biology, University of Pittsburgh, Assistant Professor (PI)
• From Jan. 2019, To Jun. 2023

  Aging Institute, Department of Medicine, University of Pittsburgh, Assistant Professor (PI)
• From Apr. 2016, To Dec. 2018

  NIH, NINDS, Richard J. Youle Lab, Visiting Research Fellow
• From Feb. 2013, To Mar. 2016

  東京大学大学院薬学系研究科細胞情報学教室, 助教
• From Apr. 2012, To Jan. 2013

  東京大学大学院薬学系研究科細胞情報学教室, 特任助教
• From Apr. 2011, To Mar. 2012

  東京大学大学院薬学系研究科細胞情報学教室, 特任研究員

ID,URL

• ORCID ID

  0000-0001-9962-833X

• J-Global ID

  202301010533489242

• Researcher number

  70612654

• External link

  https://www.shiorilab.net

researchmap URL

• https://researchmap.jp/Shiori_Sekine

Research

Research Topics, Overview of the research

• Research Topics

  Mitochondrial Stress Response

• Overview of the research

  We study how mitochondria sense environmental changes and regulate appropriate cellular responses to identify new therapeutic targets.

Research Interests

• ミトコンドリア、ストレス応答、タンパク質輸送、生体内小分子、オルガネラコミュニケーション、プロテオスタシス

Research Areas

• Life sciences, Molecular biology
• Life sciences, Cell biology

Papers

• A unified mechanism for mitochondrial damage sensing in PINK1-Parkin-mediated mitophagy.

  Julia A Thayer; Jennifer D Petersen; Xiaoping Huang; Luiza M Gruel Budet; James Hawrot; Daniel M Ramos; Shiori Sekine; Yan Li; Michael E Ward; Derek P Narendra

  The EMBO journal, 20 Nov. 2025, Peer-reviewed

  
• Mitophagy mitigates mitochondrial fatty acid β-oxidation deficient cardiomyopathy.

  Nuo Sun; Hayley Barta; Samhita Chaudhuri; Kangxuan Chen; Jiacheng Jin; Hongke Luo; Mingchong Yang; Judith Krigman; Ruohan Zhang; Shridhar Sanghvi; Shiori Sekine; Hannah Sanders; Dominic Kolonay; Mudra Patel; Kedryn Baskin; Harpreet Singh; Pengyi Zhang; Gang Xin; Toren Finkel

  Nature communications, 01 Jul. 2025, Peer-reviewed

  
• Metabolite tunes MDV pathway to maintain mitochondrial fitness.

  Shiori Sekine; Yusuke Sekine

  Molecular cell, 03 Apr. 2025, Invited, Lead author, Corresponding author

  
• OMA1 clears traffic jam in TOM tunnel in mammals.

  Shiori Sekine; Yusuke Sekine

  The Journal of cell biology, 06 May 2024, Invited, Lead author, Corresponding author

  
• A mitochondrial iron-responsive pathway regulated by DELE1.

  Yusuke Sekine; Ryan Houston; Eva-Maria Eckl; Evelyn Fessler; Derek P Narendra; Lucas T Jae; Shiori Sekine

  Molecular cell, 15 Jun. 2023, Peer-reviewed, Corresponding author

  
• TIM23 facilitates PINK1 activation by safeguarding against OMA1-mediated degradation in damaged mitochondria.

  Shiori Akabane; Kiyona Watanabe; Hidetaka Kosako; Shun-Ichi Yamashita; Kohei Nishino; Masahiro Kato; Shiori Sekine; Tomotake Kanki; Noriyuki Matsuda; Toshiya Endo; Toshihiko Oka

  Cell reports, 30 May 2023, Peer-reviewed

  
• Discovery of bactericides as an acute mitochondrial membrane damage inducer.

  Ryan Houston; Yusuke Sekine; Mads B Larsen; Kei Murakami; Steven J Mullett; Stacy G Wendell; Derek P Narendra; Bill B Chen; Shiori Sekine

  Molecular biology of the cell, 01 Nov. 2021, Peer-reviewed, Corresponding author

  
• Thiol-Cleavable Biotin for Chemical and Enzymatic Biotinylation and Its Application to Mitochondrial TurboID Proteomics.

  Haorong Li; Ashley M Frankenfield; Ryan Houston; Shiori Sekine; Ling Hao

  Journal of the American Society for Mass Spectrometry, 01 Sep. 2021, Peer-reviewed

  
• Cellular metabolic stress responses via organelles.

  Yusuke Sekine; Ryan Houston; Shiori Sekine

  Experimental cell research, 01 Mar. 2021, Peer-reviewed, Invited

  
• Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses.

  Ryan Houston; Shiori Sekine; Michael J Calderon; Fayaz Seifuddin; Guanghui Wang; Hiroyuki Kawagishi; Daniela A Malide; Yuesheng Li; Marjan Gucek; Mehdi Pirooznia; Alissa J Nelson; Matthew P Stokes; Jacob Stewart-Ornstein; Steven J Mullett; Stacy G Wendell; Simon C Watkins; Toren Finkel; Yusuke Sekine

  PLoS biology, Nov. 2020, Peer-reviewed

  
• The coupling of translational control and stress responses.

  Ryan Houston; Shiori Sekine; Yusuke Sekine

  Journal of biochemistry, 01 Aug. 2020, Peer-reviewed, Invited

  
• Loss of CHCHD2 and CHCHD10 activates OMA1 peptidase to disrupt mitochondrial cristae phenocopying patient mutations.

  Yi-Ting Liu; Xiaoping Huang; Diana Nguyen; Mario K Shammas; Beverly P Wu; Eszter Dombi; Danielle A Springer; Joanna Poulton; Shiori Sekine; Derek P Narendra

  Human molecular genetics, 03 Jun. 2020, Peer-reviewed

  
• The mitochondrial protein PGAM5 suppresses energy consumption in brown adipocytes by repressing expression of uncoupling protein 1.

  Sho Sugawara; Yusuke Kanamaru; Shiori Sekine; Lila Maekawa; Akinori Takahashi; Tadashi Yamamoto; Kengo Watanabe; Takao Fujisawa; Kazuki Hattori; Hidenori Ichijo

  The Journal of biological chemistry, 24 Apr. 2020, Peer-reviewed

  
• PINK1 import regulation at a crossroad of mitochondrial fate: the molecular mechanisms of PINK1 import.

  Shiori Sekine

  Journal of biochemistry, 01 Mar. 2020, Peer-reviewed, Invited, Lead author, Corresponding author

  
• Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1.

  Shiori Sekine; Chunxin Wang; Dionisia P Sideris; Eric Bunker; Zhe Zhang; Richard J Youle

  Molecular cell, 07 Mar. 2019, Peer-reviewed, Lead author

  
• PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol.

  Shiori Sekine; Richard J Youle

  BMC biology, 10 Jan. 2018, Peer-reviewed, Invited, Lead author

  
• Mitochondrial fission facilitates the selective mitophagy of protein aggregates.

  Jonathon L Burman; Sarah Pickles; Chunxin Wang; Shiori Sekine; Jose Norberto S Vargas; Zhe Zhang; Alice M Youle; Catherine L Nezich; Xufeng Wu; John A Hammer; Richard J Youle

  The Journal of cell biology, 02 Oct. 2017, Peer-reviewed

  
• Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly.

  Apirat Chaikuad; Panagis Filippakopoulos; Sean R Marcsisin; Sarah Picaud; Martin Schröder; Shiori Sekine; Hidenori Ichijo; John R Engen; Kohsuke Takeda; Stefan Knapp

  Structure (London, England : 1993), 05 Jul. 2017, Peer-reviewed

  
• [Mitochondrial proteolysis and its roles in stress responses].

  Shiori Sekine

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2017, Invited, Lead author, Corresponding author

  
• The Ablation of Mitochondrial Protein Phosphatase Pgam5 Confers Resistance Against Metabolic Stress.

  Shiori Sekine; Akari Yao; Kazuki Hattori; Sho Sugawara; Isao Naguro; Masato Koike; Yasuo Uchiyama; Kohsuke Takeda; Hidenori Ichijo

  EBioMedicine, Mar. 2016, Peer-reviewed, Lead author

  
• KLHDC10 Deficiency Protects Mice against TNFα-Induced Systemic Inflammation.

  Namiko Yamaguchi; Shiori Sekine; Isao Naguro; Yusuke Sekine; Hidenori Ichijo

  PloS one, 2016, Peer-reviewed

  
• Apoptosis Signal-regulating Kinase 1 (ASK1)-p38 Pathway-dependent Cytoplasmic Translocation of the Orphan Nuclear Receptor NR4A2 Is Required for Oxidative Stress-induced Necrosis.

  Takeshi Watanabe; Shiori Sekine; Isao Naguro; Yusuke Sekine; Hidenori Ichijo

  The Journal of biological chemistry, 24 Apr. 2015, Peer-reviewed

  
• Mitochondrial proteolysis: its emerging roles in stress responses.

  Shiori Sekine; Hidenori Ichijo

  Biochimica et biophysica acta, Feb. 2015, Peer-reviewed, Invited, Lead author

  
• Rhomboid protease PARL mediates the mitochondrial membrane potential loss-induced cleavage of PGAM5.

  Shiori Sekine; Yusuke Kanamaru; Masato Koike; Ayako Nishihara; Masahiro Okada; Hideyuki Kinoshita; Miki Kamiyama; Junichi Maruyama; Yasuo Uchiyama; Naotada Ishihara; Kohsuke Takeda; Hidenori Ichijo

  The Journal of biological chemistry, 05 Oct. 2012, Peer-reviewed, Lead author

  
• The phosphorylation-dependent regulation of mitochondrial proteins in stress responses.

  Yusuke Kanamaru; Shiori Sekine; Hidenori Ichijo; Kohsuke Takeda

  Journal of signal transduction, 2012, Peer-reviewed

  
• Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1.

  Kohsuke Takeda; Yoshiko Komuro; Teruyuki Hayakawa; Haruka Oguchi; Yosuke Ishida; Shiori Murakami; Takuya Noguchi; Hideyuki Kinoshita; Yusuke Sekine; Shun-ichiro Iemura; Tohru Natsume; Hidenori Ichijo

  Proceedings of the National Academy of Sciences of the United States of America, 28 Jul. 2009, Peer-reviewed

  
• Stress signaling in cancer.

  Shiori Murakami; Takuya Noguchi; Kohsuke Takeda; Hidenori Ichijo

  Cancer science, Oct. 2007, Peer-reviewed, Invited, Lead author

  
• Involvement of ROS-dependent activation of ASK1-p38 pathway in ATP-induced apoptosis in macrophage

  Takuya Noguchi; Shiori Murakami; Hisashi Fukutomi; Kohsuke Takeda; Hidenori Ichijo

  MOLECULAR BIOTECHNOLOGY, Sep. 2007, Peer-reviewed

  
• ASK1-dependent recruitment and activation of macrophages induce hair growth in skin wounds.

  Nao Osaka; Takumi Takahashi; Shiori Murakami; Atsushi Matsuzawa; Takuya Noguchi; Takeshi Fujiwara; Hiroyuki Aburatani; Keiji Moriyama; Kohsuke Takeda; Hidenori Ichijo

  The Journal of cell biology, 26 Mar. 2007, Peer-reviewed

  

Presentations

• Mitochondrial Import-Coupled Stress Response

  Sekine S.

  TokyoMito 2025, 01 Sep. 2025

  
• Mitochondrial Import-Coupled Stress Response

  Sekine S.

  OsakaMito 2025, 29 Aug. 2025

  
• Mitochondria-based Iron Monitoring Pathway and Its Role in Erythroid Survival

  Sekine S

  Gordon Research Conference, Erythropoiesis: Cellular and Molecular Mechanisms, Pathogenesis, and Clinical Translation, 09 Jun. 2025

  
• Mitochondria-based Iron Monitoring Pathway regulated by DELE1 import

  Sekine S

  Cell Symposia, Metabolites: Organellar communication in health and disease, 12 May 2025

  
• The tug-of-war of mitochondrial proteins as a sensing mechanism for stress and small biomolecules

  Sekine S

  UTAH-OSAKA MITO 2025, 23 Apr. 2025

  
• Mitochondria-based Iron Monitoring Pathway

  Sekine S

  第97回 日本生化学会, 08 Nov. 2024

  
• Mitochondria-based Iron Monitoring Pathway

  Sekine S

  FASEB conference, Trace Elements in Biology and Medicine, 11 Jun. 2024

  
• Mitochondrial Import-Coupled Stress Response

  Sekine S

  1st PittCell conference, 02 May 2024

  
• A mitochondrial iron-responsive pathway regulated by DELE1 import

  Sekine S

  第46回 日本分子生物学会, 06 Dec. 2023

  
• Mitochondrial Import-Coupled Stress Response ~ A fine system to signal from mitochondria to the cytosol~

  Sekine S

  10th Translational Research in Mitochondria/Metabolism in Aging and Disease (TRiMAD) Conference, 17 Nov. 2023

  
• Discovery of novel mitochondrial stressor that induces acute mitochondrial membrane perturbation.

  Sekine S

  第94回 日本生化学会, 2021

  
• Molecular Mechanisms of Stress-Dependent PINK1 Import Regulation.

  Sekine S

  Gordon Research Conference, Protein Transport Across Cell Membranes, 2020

  
• PINK1 import regulation at a crossroad of mitochondrial fate.

  Sekine S

  第42回 日本分子生物学会, 2019

  
• Stress-dependent PINK1 import regulation.

  Sekine S

  1st International YoungMito Meeting, 2018

  
• PARL-mediated cleavage of PGAM5 in stress responses.

  Sekine S

  EMBO workshop Mitochondrial Quality Control, 2017

  
• The Analysis of stress response in mitochondria.

  Sekine S

  第89回 日本薬理学会, 2016

  

Books and Other Publications

• マイトファジー：オートファゴソーム・リソソーム形成機構

  関根史織

  実験医学：ユビキチン化を介したオルガネロファジー（羊土社）, 2017

  
• ミトコンドリア局在型プロテインホスファターゼPGAM5とストレス応答

  医学のあゆみ：ストレスシグナルと疾患―細胞恒常性維持機構の破綻と病態（医歯薬出版）, 2015

  
• 生体内のROS管理の破綻とがん形成

  関根史織; 一條秀憲

  実験医学増刊号：in vivo実験医学によるヒト疾患解明の最前線（羊土社）, 2012

  
• ASK1のシグナル伝達

  村上史織; 野口拓也; 一條秀憲

  神経変性疾患のサイエンス（南山堂）, 2007

  

External funds: Kakenhi

• Molecular dissection of mitochondrial stress response

  Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)

  Biological Science

  Kyoto University

  関根 史織

  From 15 Feb. 2026, To 31 Mar. 2029, Granted

  ミトコンドリア;ストレス応答;シグナル伝達;タンパク質輸送;プロテオスタシス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K24922/
• Signal transduction by redox sensor molecules

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Osaka University

  Hiroaki Miki

  From 10 Jul. 2014, To 31 Mar. 2019, Project Closed

  シグナル伝達;ストレス

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-26111007/
• Homeostasis Regulation via Stress Signaling and its Molecular Basis for Drug Development

  Grant-in-Aid for Scientific Research (S)

  The University of Tokyo

  Hidenori ICHIJO

  From 31 May 2013, To 31 Mar. 2018, Project Closed

  ASK1;ASKファミリー;酸化ストレス;浸透圧ストレス;小胞体ストレス;ミトコンドリアストレス;シグナル伝達;ストレス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25221302/

Education

Teaching subject(s)

• From 01 Apr. 2026, To 31 Mar. 2027

  Early Research Exposure

  C504, Fall, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Introduction Seminar for Research Training B

  C506, Fall, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Introduction Seminar for Research Training A

  C505, Fall, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Early Research Exposure

  C504, Spring, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Laboratory Practice in Basic Molecular Biology

  4204, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2026, To 31 Mar. 2027

  Research Training(Organelle Signaling)

  D182, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2026, To 31 Mar. 2027

  Research Training(Organelle Signaling)

  E830, Year-long, Faculty of Pharmaceutical Sciences, 14
• From 01 Apr. 2026, To 31 Mar. 2027

  Biological Chemistry 1 (Biomolecules)

  A201, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Biological Chemistry 1 (Biomolecules)

  C201, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Research in Basic Molecular Biology

  3204, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2026, To 31 Mar. 2027

  Pharmaceutical Laboratory IV : Biochemistry and Microbiology

  C906, Fall, Faculty of Pharmaceutical Sciences, 3
• From 01 Apr. 2026, To 31 Mar. 2027

  Introduction to Pharmaceutical Biochemistry

  8103, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Basic Molecular Biology Seminar

  2304, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Introduction to Modern Life Sciences for Drug Discovery

  1027, Spring, Graduate School of Pharmaceutical Sciences, 2

Administration

School management (title, position)

• From 01 Apr. 2026, To 31 Mar. 2028

  京都大学大学院教育支援機構ＳＰＲＩＮＧプログラム　健康・医療・生命分野選考委員会 委員