Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医学専攻 遺伝子改変動物学, 助教
• Graduate School of Medicine, 医科学専攻 遺伝子改変動物学, 助教

Academic Degree

• 修士（学術）(放送大学)

ID,URL

• J-Global ID

  201601003883518260

Research

Research Areas

• Life sciences, Laboratory animal science

Papers

• Dynamic interactions between cartilaginous and tendinous/ligamentous primordia during musculoskeletal integration.

  Xinyi Yu; Ryosuke Kawakami; Shinsei Yambe; Yuki Yoshimoto; Takako Sasaki; Shinnosuke Higuchi; Hitomi Watanabe; Haruhiko Akiyama; Shigenori Miura; Kadi Hu; Gen Kondoh; Ramu Sagasaki; Masafumi Inui; Taiji Adachi; Denitsa Docheva; Takeshi Imamura; Chisa Shukunami

  Development (Cambridge, England), 15 Mar. 2025

  
• A feedback amplifier circuit with Notch and E2A orchestrates T-cell fate and suppresses the innate lymphoid cell lineages during thymic ontogeny.

  Kazuko Miyazaki; Kenta Horie; Hitomi Watanabe; Reiko Hidaka; Rinako Hayashi; Norihito Hayatsu; Kentaro Fujiwara; Rei Kuwata; Takuya Uehata; Yotaro Ochi; Makoto Takenaka; Risa Karakida Kawaguchi; Koichi Ikuta; Osamu Takeuchi; Seishi Ogawa; Katsuto Hozumi; Georg A Holländer; Gen Kondoh; Taishin Akiyama; Masaki Miyazaki

  Genes & development, 04 Feb. 2025

  
• CD1530, selective RARγ agonist, facilitates Achilles tendon healing by modulating the healing environment including less chondrification in a mouse model.

  Dilimulati Yimiti; Kenta Uchibe; Minoru Toriyama; Yuta Hayashi; Yasunari Ikuta; Tomoyuki Nakasa; Haruhiko Akiyama; Hitomi Watanabe; Gen Kondoh; Aki Takimoto; Chisa Shukunami; Nobuo Adachi; Shigeru Miyaki

  Journal of orthopaedic research : official publication of the Orthopaedic Research Society, Feb. 2025

  
• 腫瘍内微小環境におけるHIF活性化間質細胞の経時的イメージング

  宮原 瞳; 平野 龍一郎; 渡邊 重明; 渡邊 仁美; 口丸 高弘; 門之園 哲哉; 近藤 玄; 近藤 科江

  JSMI Report, Apr. 2022

  
• TNBC腫瘍における組織常在性間質細胞の解析

  平野 龍一郎; 岡本 浩輝; 新毛 実結; 渡邊 仁美; 近藤 玄; 門之園 哲也; 近藤 科江

  JSMI Report, May 2021

  
• HIF応答性発光イメージングマウスを用いた宿主由来HIF活性化細胞の腫瘍内イメージング

  宮原 瞳; 平野 龍一郎; 口丸 高弘; 門之園 哲哉; 渡邊 仁美; 近藤 玄; 近藤 科江

  JSMI Report, May 2019

  
• A RORE-dependent Intronic Enhancer in the IL-7 Receptor-α Locus Controls Glucose Metabolism via Vγ4+ γδT17 Cells

  Shizue Tani-ichi; David Obwegs; Alice Yoshikawa; Hitomi Watanabe; Satsuki Kitano; Aki Ejima; Shinya Hatano; Hitoshi Miyachi; Guangwei Cui; Akihiro Shimba; Shinya Abe; Shohei Hori; Gen Kondoh; Sagar; Yasunobu Yoshikai; Koichi Ikuta

  The Journal of Immunology, 12 Jun. 2024, Peer-reviewed

  
• A newly identified gene Ahed plays essential roles in murine haematopoiesis.

  Ritsuko Nakai; Takafumi Yokota; Masahiro Tokunaga; Mikiro Takaishi; Tomomasa Yokomizo; Takao Sudo; Henyun Shi; Yoshiaki Yasumizu; Daisuke Okuzaki; Chikara Kokubu; Sachiyo Tanaka; Katsuyoshi Takaoka; Ayako Yamanishi; Junko Yoshida; Hitomi Watanabe; Gen Kondoh; Kyoji Horie; Naoki Hosen; Shigetoshi Sano; Junji Takeda

  Nature communications, 25 Jun. 2024

  
• Transcriptome Analysis by RNA Sequencing of Mouse Embryonic Stem Cells Stocked on International Space Station for 1584 Days in Frozen State after Culture on the Ground.

  Kayo Yoshida; Megumi Hada; Masami Hayashi; Akane Kizu; Kohei Kitada; Kiyomi Eguchi-Kasai; Toshiaki Kokubo; Takeshi Teramura; Hiromi Hashizume Suzuki; Hitomi Watanabe; Gen Kondoh; Aiko Nagamatsu; Premkumar Saganti; Masafumi Muratani; Francis A Cucinotta; Takashi Morita

  International journal of molecular sciences, 14 Mar. 2024

  
• Dual-color live imaging unveils stepwise organization of multiple basal body arrays by cytoskeletons.

  Gen Shiratsuchi; Satoshi Konishi; Tomoki Yano; Yuichi Yanagihashi; Shogo Nakayama; Tatsuya Katsuno; Hiroka Kashihara; Hiroo Tanaka; Kazuto Tsukita; Koya Suzuki; Elisa Herawati; Hitomi Watanabe; Toyohiro Hirai; Takeshi Yagi; Gen Kondoh; Shimpei Gotoh; Atsushi Tamura; Sachiko Tsukita

  EMBO reports, Mar. 2024

  
• Notch2 with retinoic acid license IL-23 expression by intestinal EpCAM+ DCIR2+ cDC2s in mice.

  Daiya Ohara; Yusuke Takeuchi; Hitomi Watanabe; Yoonha Lee; Hiroki Mukoyama; Toshiaki Ohteki; Gen Kondoh; Keiji Hirota

  The Journal of experimental medicine, 05 Feb. 2024

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• Regulation of lymphoid-myeloid lineage bias through regnase-1/3-mediated control of Nfkbiz.

  Takuya Uehata; Shinnosuke Yamada; Daisuke Ori; Alexis Vandenbon; Amir Giladi; Adam Jelinski; Yasuhiro Murakawa; Hitomi Watanabe; Kazuhiro Takeuchi; Kazunori Toratani; Takashi Mino; Hisanori Kiryu; Daron M Standley; Tohru Tsujimura; Tomokatsu Ikawa; Gen Kondoh; Markus Landthaler; Hiroshi Kawamoto; Hans-Reimer Rodewald; Ido Amit; Ryo Yamamoto; Masaki Miyazaki; Osamu Takeuchi

  Blood, 18 Jan. 2024

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• Sclerostin modulates mineralization degree and stiffness profile in the fibrocartilaginous enthesis for mechanical tissue integrity.

  Shinsei Yambe; Yuki Yoshimoto; Kazutaka Ikeda; Koichiro Maki; Aki Takimoto; Akihide Tokuyama; Shinnosuke Higuchi; Xinyi Yu; Kenta Uchibe; Shigenori Miura; Hitomi Watanabe; Tetsushi Sakuma; Takashi Yamamoto; Kotaro Tanimoto; Gen Kondoh; Masataka Kasahara; Toshihide Mizoguchi; Denitsa Docheva; Taiji Adachi; Chisa Shukunami

  Frontiers in cell and developmental biology, 2024

  
• Ebf3+ niche-derived CXCL12 is required for the localization and maintenance of hematopoietic stem cells.

  Taichi Nakatani; Tatsuki Sugiyama; Yoshiki Omatsu; Hitomi Watanabe; Gen Kondoh; Takashi Nagasawa

  Nature communications, 25 Oct. 2023

  
• In vivo optical imaging of tumor stromal cells with hypoxia-inducible factor activity.

  Hitomi Miyabara; Ryuichiro Hirano; Shigeaki Watanabe; John Clyde Co Soriano; Hitomi Watanabe; Takahiro Kuchimaru; Nobuo Kitada; Tetsuya Kadonosono; Shojiro A Maki; Gen Kondoh; Shinae Kizaka-Kondoh

  Cancer science, Oct. 2023

  
• Phase separation of an actin nucleator by junctional microtubules regulates epithelial function.

  Kazuto Tsukita; Manabu Kitamata; Hiroka Kashihara; Tomoki Yano; Ikuko Fujiwara; Timothy F Day; Tatsuya Katsuno; Jaewon Kim; Fumiko Takenaga; Hiroo Tanaka; Sungsu Park; Makoto Miyata; Hitomi Watanabe; Gen Kondoh; Ryosuke Takahashi; Atsushi Tamura; Sachiko Tsukita

  Science advances, 15 Feb. 2023

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• Synchronization of the ovulation and copulation timings increased the number of in vivo fertilized oocytes in superovulated female mice

  Satohiro Nakao; Kotono Ito; Chihiro Sugahara; Hitomi Watanabe; Gen Kondoh; Naomi Nakagata; Toru Takeo

  PLoS One, 07 Feb. 2023, Peer-reviewed

  
• Tissue-resident macrophages are major tumor-associated macrophage resources, contributing to early TNBC development, recurrence, and metastases.

  Ryuichiro Hirano; Koki Okamoto; Miyu Shinke; Marika Sato; Shigeaki Watanabe; Hitomi Watanabe; Gen Kondoh; Tetsuya Kadonosono; Shinae Kizaka-Kondoh

  Communications biology, 03 Feb. 2023

  
• Dimethyl-α-cyclodextrin induces capacitation by removing phospholipids from the plasma membrane of mouse sperm

  Satohiro Nakao; Kotono Ito; Kazuhito Sakoh; Kenji Takemoto; Hitomi Watanabe; Gen Kondoh; Tetsumi Irie; Naomi Nakagata; Toru Takeo

  Biology of Reproduction, 01 Feb. 2023

  
• Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells

  Yoshiki Omatsu; Shota Aiba; Tomonori Maeta; Kei Higaki; Kazunari Aoki; Hitomi Watanabe; Gen Kondoh; Riko Nishimura; Shu Takeda; Ung-il Chung; Takashi Nagasawa

  Nature Communications, Dec. 2022

  
• Comparison of biological measurement and physical estimates of space radiation in the International Space Station.

  Kayo Yoshida; Megumi Hada; Akane Kizu; Kohei Kitada; Kiyomi Eguchi-Kasai; Toshiaki Kokubo; Takeshi Teramura; Sachiko Yano; Hiromi Hashizume Suzuki; Hitomi Watanabe; Gen Kondoh; Aiko Nagamatsu; Premkumar Saganti; Francis A Cucinotta; Takashi Morita

  Heliyon, Aug. 2022

  
• A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis

  Toshinori Nakagawa; David J. Jörg; Hitomi Watanabe; Seiya Mizuno; Seungmin Han; Tatsuro Ikeda; Yoshiki Omatsu; Keiko Nishimura; Miyako Fujita; Satoru Takahashi; Gen Kondoh; Benjamin D. Simons; Shosei Yoshida; Takashi Nagasawa

  Cell Reports, Oct. 2021

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• Dispensable roles of Gsdmd and Ripk3 in sustaining IL-1β production and chronic inflammation in Th17-mediated autoimmune arthritis.

  Yusuke Takeuchi; Daiya Ohara; Hitomi Watanabe; Noriko Sakaguchi; Shimon Sakaguchi; Gen Kondoh; Akio Morinobu; Tsuneyo Mimori; Keiji Hirota

  Scientific reports, 21 Sep. 2021

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• Distinct Foxp3 enhancer elements coordinate development, maintenance, and function of regulatory T cells

  Ryoji Kawakami; Yohko Kitagawa; Kelvin Y. Chen; Masaya Arai; Daiya Ohara; Yamami Nakamura; Keiko Yasuda; Motonao Osaki; Norihisa Mikami; Caleb A. Lareau; Hitomi Watanabe; Gen Kondoh; Keiji Hirota; Naganari Ohkura; Shimon Sakaguchi

  Immunity, May 2021

  
• ABCA13 dysfunction associated with psychiatric disorders causes impaired cholesterol trafficking.

  Mitsuhiro Nakato; Naoko Shiranaga; Maiko Tomioka; Hitomi Watanabe; Junko Kurisu; Mineko Kengaku; Naoko Komura; Hiromune Ando; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  The Journal of biological chemistry, 2021

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• Circadian key component CLOCK/BMAL1 interferes with segmentation clock in mouse embryonic organoids

  Yasuhiro Umemura; Nobuya Koike; Yoshiki Tsuchiya; Hitomi Watanabe; Gen Kondoh; Ryoichiro Kageyama; Kazuhiro Yagita

  31 Oct. 2020

  
• Foxp3+ Regulatory T Cells Inhibit CCl4-Induced Liver Inflammation and Fibrosis by Regulating Tissue Cellular Immunity

  Yoshinobu Ikeno; Daiya Ohara; Yusuke Takeuchi; Hitomi Watanabe; Gen Kondoh; Kojiro Taura; Shinji Uemoto; Keiji Hirota

  Frontiers in Immunology, 15 Oct. 2020

  
• Strain-Dependent Prion Infection in Mice Expressing Prion Protein with Deletion of Central Residues 91-106.

  Keiji Uchiyama; Hironori Miyata; Yoshitaka Yamaguchi; Morikazu Imamura; Mariya Okazaki; Agriani Dini Pasiana; Junji Chida; Hideyuki Hara; Ryuichiro Atarashi; Hitomi Watanabe; Gen Kondoh; Suehiro Sakaguchi

  International journal of molecular sciences, 01 Oct. 2020

  
• The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells

  Kazuko Miyazaki; Hitomi Watanabe; Genki Yoshikawa; Kenian Chen; Reiko Hidaka; Yuki Aitani; Kai Osawa; Rie Takeda; Yotaro Ochi; Shizue Tani-ichi; Takuya Uehata; Osamu Takeuchi; Koichi Ikuta; Seishi Ogawa; Gen Kondoh; Yin C. Lin; Hiroyuki Ogata; Masaki Miyazaki

  Science Immunology, 04 Sep. 2020

  
• Successful selection of mouse sperm with high viability and fertility using microfluidics chip cell sorter.

  Satohiro Nakao; Toru Takeo; Hitomi Watanabe; Gen Kondoh; Naomi Nakagata

  Scientific reports, 01 Jun. 2020, Peer-reviewed

  
• Enhanced homologous recombination by the modulation of targeting vector ends.

  Shinji Hirotsune; Hiroshi Kiyonari; Mingyue Jin; Kanako Kumamoto; Kayo Yoshida; Miki Shinohara; Hitomi Watanabe; Anthony Wynshaw-Boris; Fumio Matsuzaki

  Scientific reports, 13 Feb. 2020, Peer-reviewed

  
• The N-Terminal Polybasic Region of Prion Protein Is Crucial in Prion Pathogenesis Independently of the Octapeptide Repeat Region.

  Nandita Rani Das; Hironori Miyata; Hideyuki Hara; Junji Chida; Keiji Uchiyama; Kentaro Masujin; Hitomi Watanabe; Gen Kondoh; Suehiro Sakaguchi

  Molecular neurobiology, Feb. 2020, Peer-reviewed

  
• Dephosphorylation of protamine 2 at serine 56 is crucial for murine sperm maturation in vivo.

  Itoh K; Kondoh G; Miyachi H; Sugai M; Kaneko Y; Kitano S; Watanabe H; Maeda R; Imura A; Liu Y; Ito C; Itohara S; Toshimori K; Fujita J

  Sci Signal., Mar. 2019, Peer-reviewed

  
• Differential transactivation of the upstream aggrecan enhancer regulated by PAX1/9 depends on SOX9-driven transactivation.

  Takimoto A; Kokubu C; Watanabe H; Sakuma T; Yamamoto T; Kondoh G; Hiraki Y; Shukunami C

  Sci Rep., Mar. 2019, Peer-reviewed

  
• Satb1 regulates the effector program of encephalitogenic tissue Th17 cells in chronic inflammation.

  Yasuda K; Kitagawa Y; Kawakami R; Isaka Y; Watanabe H; Kondoh G; Kohwi-Shigematsu T; Sakaguchi S; Hirota K

  Nat Commun., Feb. 2019, Peer-reviewed

  
• 細胞分化異常に起因する癌における概日時計の破綻

  梅村 康浩; 大橋 宗洋; 小池 宣也; 土谷 佳樹; 稲田 裕; 渡邊 仁美; 田中 智子; 南 陽一; 浮村 理; 三木 恒治; 田尻 達郎; 近藤 玄; 山田 泰広; 八木田 和弘

  日本生化学会大会プログラム・講演要旨集, Sep. 2018

  
• An inflammatory cellular cascade of autoimmune Th17 cells, GM-CSF-producing ILC2 and synoviocytes in the development of autoimmune arthritis

  Hirota, K; Ito, Y; Hashimoto, M; Watanabe, H; Kondoh, G; Tanaka, A; Yasuda, K; Kopf, M; Potocnik, AJ; Stockinger, B; Sakaguchi, N; Sakaguchi, S

  Immunity, Jun. 2018, Peer-reviewed

  
• Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis.

  Hirota K; Hashimoto M; Ito Y; Matsuura M; Ito H; Tanaka M; Watanabe H; Kondoh G; Tanaka A; Yasuda K; Kopf M; Potocnik AJ; Stockinger B; Sakaguchi N; Sakaguchi S

  Immunity, May 2018, Peer-reviewed

  
• PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.

  Mami Morita; Taku Sato; Miyuki Nomura; Yoshimi Sakamoto; Yui Inoue; Ryota Tanaka; Shigemi Ito; Koreyuki Kurosawa; Kazunori Yamaguchi; Yuki Sugiura; Hiroshi Takizaki; Yoji Yamashita; Ryuichi Katakura; Ikuro Sato; Masaaki Kawai; Yoshinori Okada; Hitomi Watanabe; Gen Kondoh; Shoko Matsumoto; Ayako Kishimoto; Miki Obata; Masaki Matsumoto; Tatsuro Fukuhara; Hozumi Motohashi; Makoto Suematsu; Masaaki Komatsu; Keiichi I Nakayama; Toshio Watanabe; Tomoyoshi Soga; Hiroshi Shima; Makoto Maemondo; Nobuhiro Tanuma

  Cancer cell, 12 Mar. 2018, Peer-reviewed

  
• Stem cell niche-specific Ebf3 maintains the bone marrow cavity

  Masanari Seike; Yoshiki Omatsu; Hitomi Watanabe; Gen Kondoh; Takashi Nagasawa

  Genes and Development, 01 Mar. 2018, Peer-reviewed

  
• Disruption of circadian clockwork in in vivo reprogramming-induced mouse kidney tumors

  Munehiro Ohashi; Yasuhiro Umemura; Nobuya Koike; Yoshiki Tsuchiya; Yutaka Inada; Hitomi Watanabe; Tomoko Tanaka; Yoichi Minami; Osamu Ukimura; Tsuneharu Miki; Tatsuro Tajiri; Gen Kondoh; Yasuhiro Yamada; Kazuhiro Yagita

  Genes to Cells, 01 Feb. 2018, Peer-reviewed

  
• Scleraxis is a transcriptional activator that regulates the expression of Tenomodulin, a marker of mature tenocytes and ligamentocytes.

  Shukunami C; Takimoto A; Nishizaki Y; Yoshimoto Y; Tanaka S; Miura S; Watanabe H; Sakuma T; Yamamoto T; Kondoh G; Hiraki Y

  Sci Rep., Feb. 2018, Peer-reviewed

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• Novel adherent CD11b⁺ Gr-1⁺ tumor-infiltrating cells initiate an immunosuppressive tumor microenvironment

  Takuya Tsubaki; Tetsuya Kadonosono; Shimon Sakurai; Tadashi Shiozawa; Toshiki Goto; Shiori Sakai; Takahiro Kuchimaru; Takeharu Sakamoto; Hitomi Watanabe; Gen Kondoh; Shinae Kizaka-Kondoh

  Oncotarget, 2018, Peer-reviewed

  
• PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice

  Ayako L. Mochizuki; Ami Katanaya; Eri Hayashi; Mihoko Hosokawa; Emiko Moribe; Akira Motegi; Masamichi Ishiai; Minoru Takata; Gen Kondoh; Hitomi Watanabe; Norio Nakatsuji; Shinichiro Chuma

  MOLECULAR AND CELLULAR BIOLOGY, Dec. 2017, Peer-reviewed

  
• Prion Protein Devoid of the Octapeptide Repeat Region Delays Bovine Spongiform Encephalopathy Pathogenesis in Mice.

  Hara H; Miyata H; Das NR; Chida J; Yoshimochi T; Uchiyama K; Watanabe H; Kondoh G; Yokoyama T; Sakaguchi S

  J Virol., Dec. 2017, Peer-reviewed

  
• 細胞分化異常が引き起こすマウス・ヒト悪性腫瘍では概日リズム分子機構が破綻している

  大橋 宗洋; 梅村 康浩; 小池 宣也; 南 陽一; 渡邊 仁美; 田中 智子; 本郷 文弥; 三木 恒治; 浮村 理; 田尻 達郎; 近藤 玄; 山田 泰広; 八木田 和弘

  日本癌学会総会記事, Sep. 2017

  
• Effects of prion protein devoid of the N-terminal residues 25-50 on prion pathogenesis in mice

  Nandita Rani Das; Hironori Miyata; Hideyuki Hara; Keiji Uchiyama; Junji Chida; Masashi Yano; Hitomi Watanabe; Gen Kondoh; Suehiro Sakaguchi

  ARCHIVES OF VIROLOGY, Jul. 2017, Peer-reviewed

  
• Scleraxis is required for maturation of tissue domains for proper integration of the musculoskeletal system

  Yuki Yoshimoto; Aki Takimoto; Hitomi Watanabe; Yuji Hiraki; Gen Kondoh; Chisa Shukunami

  SCIENTIFIC REPORTS, Mar. 2017, Peer-reviewed

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• Lipid raft dynamics linked to sperm competency for fertilization in mice.

  Hitomi Watanabe; Rie Takeda; Keiji Hirota; Gen Kondoh

  Genes Cells., Mar. 2017, Peer-reviewed

  
• マウス精子成熟における遺伝的背景の影響について

  渡邊 仁美; 竹田 理恵; 廣田 圭司; 近藤 玄

  日本IVF学会雑誌, 2017, Peer-reviewed

  
• Disruption of MeCP2 attenuates circadian rhythm in CRISPR/Cas9-based Rett syndrome model mouse

  Yoshiki Tsuchiya; Yoichi Minami; Yasuhiro Umemura; Hitomi Watanabe; Daisuke Ono; Wataru Nakamura; Tomoyuki Takahashi; Sato Honma; Gen Kondoh; Toyojiro Matsuishi; Kazuhiro Yagita

  GENES TO CELLS, Dec. 2015, Peer-reviewed

  
• Lipocalin 2 binds to membrane phosphatidylethanolamine to induce lipid raft movement in a PKA-dependent manner and modulates sperm maturation

  Hitomi Watanabe; Toru Takeo; Hiromasa Tojo; Kazuhito Sakoh; Thorsten Berger; Naomi Nakagata; Tak W. Mak; Gen Kondoh

  Development (Cambridge), 2014, Peer-reviewed

  
• 哺乳類の概日リズム表現型のES細胞ベース評価システム(ES cell-based evaluation system of circadian phenotypes in mammals)

  梅村 康浩; 吉田 純子; 和田 雅史; 土谷 佳樹; 南 陽一; 渡邊 仁美; 近藤 玄; 竹田 潤二; 井之川 仁; 堀江 恭二; 八木田 和弘

  日本生化学会大会プログラム・講演要旨集, Sep. 2013

  
• An In Vitro ES Cell-Based Clock Recapitulation Assay Model Identifies CK2 alpha as an Endogenous Clock Regulator

  Yasuhiro Umemura; Junko Yoshida; Masashi Wada; Yoshiki Tsuchiya; Yoichi Minami; Hitomi Watanabe; Gen Kondoh; Junji Takeda; Hitoshi Inokawa; Kyoji Horie; Kazuhiro Yagita

  PLOS ONE, Jun. 2013, Peer-reviewed

  
• Detection of the Onset of Ischemia and Carcinogenesis by Hypoxia-Inducible Transcription Factor-Based In Vivo Bioluminescence Imaging

  Tetsuya Kadonosono; Takahiro Kuchimaru; Shuichi Yamada; Yumi Takahashi; Atsushi Murakami; Taeko Tani; Hitomi Watanabe; Tomoharu Tanaka; Kiichi Hirota; Masahiro Inoue; Tetsuya Tsukamoto; Takeshi Toyoda; Koji Urano; Kazuhiko Machida; Tomoo Eto; Tomoyuki Ogura; Hideki Tsutsumi; Mamoru Ito; Masahiro Hiraoka; Gen Kondoh; Shinae Kizaka-Kondoh

  PLOS ONE, Nov. 2011, Peer-reviewed

  
• Mouse sperm undergo GPI-anchored protein release associated with lipid raft reorganization and acrosome reaction to acquire fertility

  Hitomi Watanabe; Gen Kondoh

  JOURNAL OF CELL SCIENCE, Aug. 2011, Peer-reviewed

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• Testicular Angiotensin-converting enzyme with different glycan modification: characterization on glycosylphosphatidylinositol-anchored protein releasing and dipeptidase activities.

  Kondoh G; Watanabe H; Tashima Y; Maeda Y; Kinoshita T

  J Biochem., Nov. 2008, Peer-reviewed

  
• Dipeptidase-inactivated tACE action in vivo: selective inhibition of sperm-zona pellucida binding in the mouse.

  Deguchi E; Tani T; Watanabe H; Yamada S; Kondoh G

  Biol Reprod., Jul. 2007, Peer-reviewed

  

Misc.

• 新規遺伝子AhedはRNAスプライシングを通じて造血に必須な役割を果たす

  中井 りつこ; 横田 貴史; 徳永 正浩; 高石 樹朗; 数藤 孝雄; 施 亨韻; 安水 良明; 奥崎 大介; 國府 力; 田中 幸代; 高岡 勝吉; 山西 絢子; 吉田 純子; 渡邊 仁美; 近藤 玄; 堀江 恭二; 保仙 直毅; 佐野 栄紀; 竹田 潤二

  日本血液学会学術集会, Oct. 2023

  
• Inflammatory circuit of Th17 cells, fibroblast-like synoviocytes, and ILCs in the development of autoimmune arthritis

  K. Hirota; Y. Ito; M. Hashimoto; H. Watanabe; G. Kondoh; A. Tanaka; K. Yasuda; M. Kopf; A. J. Potocnik; B. Stockinger; N. Sakaguchi; S. Sakaguchi

  EUROPEAN JOURNAL OF IMMUNOLOGY, Aug. 2016

  
• 分子生物学的アプローチによる運動器研究の新展開 転写因子Scleraxisは筋骨格系を連結する組織の成熟を制御する

  吉本 由紀; 滝本 晶; 渡邊 仁美; 近藤 玄; 佐久間 哲史; 山本 卓; 開 祐司; 宿南 知佐

  生命科学系学会合同年次大会, Dec. 2017

  
• 概日時計コア因子CLOCK/BMAL1による体節時計振動への干渉作用

  梅村康浩; 小池宣也; 土谷佳樹; 渡邊仁美; 近藤玄; 影山龍一郎; 影山龍一郎; 八木田和弘

  日本生理学雑誌(Web), 2022

  
• マウス精子受精能とラフト局在変化の相関性

  渡邊仁美; 竹田理恵; 廣田圭司; 近藤玄

  日本実験動物学会総会講演要旨集, 27 Apr. 2018

  
• マウス精子成熟における遺伝的背景の影響について

  渡邊仁美; 竹田理恵; 廣田圭司; 近藤玄

  日本IVF学会雑誌, 16 Sep. 2016

  
• マウス雌生殖器内における精子膜変化と受精能獲得

  近藤玄; 渡邊仁美; 竹尾透; 中潟直己

  第57 回日本生 殖医学会学術講演会・総会2012，長崎市．, 2012, Peer-reviewed

  
• マウス雌生殖路内における精子膜変化

  渡邊 仁美; 近藤 玄

  第14 回日本IVF 学会、2011、東京都。（優秀 発表賞受賞）, 2011, Peer-reviewed

  
• マウス精子におけるGPI アンカー型タンパク質遊離と受精能獲得との相関

  渡邊仁美; 折橋郁; 近藤玄

  第57 回日本実験動物学会，2010.5.12~5.14，京都市．, 2010, Peer-reviewed

  
• Lipid raft mobility-associated GPI-anchored protein release for sperm capacitation \nin mouse.

  Kondoh G; Watanabe H; Orihashi H

  11th International Symposium on Spermatology（. 2010. 6. 24～6.29, Okinawa, Japan）, 2010, Peer-reviewed

  
• マウス精子におけるGPI アンカー型タンパク質動態の追跡と受精能獲得との相関．

  近藤玄; 渡邊仁美; 折橋郁

  第32 回日本分子生物学会，2009.12.9～12.12，横浜市．, 2009, Peer-reviewed

  
• マウス精子におけるGPI アンカー型タンパク質動態を追跡するためのレポーターマウスの作出と解析

  渡邊仁美; 谷妙子; 村上惇; 折橋郁; 近藤玄

  第56回日本実験動物学会，2009.5.14～5.16，さいたま市．, 2009, Peer-reviewed

  
• 精巣型アンギオテンシン変換酵素の糖鎖修飾と機能

  近藤玄; 渡邊仁美; 田嶌優子; 前田裕輔; 木下タロウ

  第55回日本実験動物学会総会（2008.5.15-17．仙台市）, 2008, Peer-reviewed

  
• ジペプシダーゼ欠損型アンギオテンシン変換酵素（ACE）を用いた精子機能解析

  近藤玄; 出口央士; 谷妙子; 渡邊仁美; 山田秀一

  第30 回日本分子生物学会・第80 日本生化学会合同大会（2007. 12.11－12.15，横浜市）, 2007, Peer-reviewed

  
• ペプチダーゼ欠損型アンギオテンシン変換酵素 （ACE）の機能解析

  出口央士; 渡邊仁美; 吉田佳世; 森田隆; 山田秀一; 近藤玄

  第53 回日本実験動物学会（2006.5.11）神戸市, 2006, Peer-reviewed

  

Presentations

• 精子受精能獲得過程における精子膜変化

  渡邊 仁美

  第4回 雄性生殖研究会, 09 Mar. 2024, Invited

  
• マウス精子受精能とラフト局在変化の相関性

  渡邊 仁美

  日本実験動物学会総会, 16 May 2018

  
• マウス精子成熟における遺伝的背景の影響について

  渡邊 仁美

  生殖工学研究会, 02 Dec. 2017

  
• マウス精子成熟における遺伝的背景における影響について

  渡邊 仁美

  関西実験動物研究会, 01 Dec. 2017

  
• 精子成熟因子としての自然免疫因子リポカリン2

  渡邊 仁美; 竹尾 透; 東城 博雅; 酒勾 一仁; 中潟 直己; Tak Mak; 近藤 玄

  第61回日本実験動物学会総会, 15 May 2014

  
• リポカリン2による雌生殖路内における精子成熟機構の解明

  渡邊 仁美; 竹尾 透; 東城 博雅; 酒勾 一仁; 中潟 直己; 近藤 玄

  第60回 日本実験動物学会総会, 15 May 2013

  
• マウス雌生殖器内における精子膜変化

  渡邊 仁美; 近藤 玄

  日本IVF学会, 23 Oct. 2011

  
• マウス雌生殖器内における精子膜変化

  渡邊 仁美; 近藤 玄

  日本実験動物学会総会, 25 May 2011

  

Awards

• 23 Oct. 2011

  IVF学会, 優秀賞

External funds: Kakenhi

• Male regulation of pregnancy revealed by a novel GPI-anchored protein

  Grant-in-Aid for Early-Career Scientists

  Basic Section 42030:Animal life science-related

  Kyoto University

  Hitomi Watanabe

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  受精;精子;精子表面タンパク質;体外受精;マウス;GPIアンカー型タンパク質;精子機能;妊娠制御;マウス精子;精子運動性解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K15691/
• Reconstruction of human immune system in mice

  Grant-in-Aid for Scientific Research (B)

  Basic Section 42040:Laboratory animal science-related

  Osaka University

  Junji Takeda

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  細胞融合;ヒト化マウス;マウスES細胞;HLA(MHC);HLA;マウス ES細胞;HLA遺伝子座;ヒト免疫系の再構築;遺伝子組み換え

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03147/
• Sperm maturation induced by immunocompetent cells and symbiotic bacteria

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Hitomi Watanabe

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  精子;Lipocalin2;免疫担当細胞;常在細菌叢;性ホルモン制御;精子活性化;子宮粘膜;RAG2依存性免疫細胞;インヒビン;卵巣腫瘍;卵巣由来分泌因子;Ｌｃｎ２;免疫細胞;生殖ホルモン;Lcn2;受精メカニズム;精子成熟化シグナル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K21098/

Administration

Faculty management (title, position)

• From 01 Apr. 2023, To 31 Mar. 2024

  病原体安全管理委員会　委員
• From 01 May 2022, To 30 Apr. 2024

  衛生管理者
• From 01 May 2022, To 31 Mar. 2024

  安全衛生委員会　委員
• From 01 Oct. 2016

  化学物質管理委員会　委員