Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医学専攻 免疫制御, 助教
• Graduate School of Medicine, 医科学専攻 免疫制御, 助教
• Graduate School of Pharmaceutical Sciences, 薬科学専攻 免疫制御学, 助教

Professional Memberships

• From Apr. 2020, To Present

  Japanese Society for Bioinformatics
• 日本分子生物学会

Academic Degree

• 理学修士(京都大学)
• 理学博士(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院理学研究科修士課程植物学専攻, 修了
• 京都大学, 大学院理学研究科博士後期課程植物学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 京都大学, 理学部, 卒業

Language of Instruction

• English

ID,URL

• J-Global ID

  200901039564920721

researchmap URL

• https://researchmap.jp/read0012384

Research

Research Topics, Overview of the research

• Research Topics

  endogenous retrovirus silencing

• Overview of the research

  Histone posttranslational modifications play crucial roles in epigenetic regulation of chromatin structure and function. H3K9me3 is required for the DNA methylation-independent retrovirus silencing in murine ES cells. In non-embryonic cells, however, H3K9me3 is not always necessary for prohibiting retrovirus from derepression.

Research Interests

• ゲノム情報科学
• Bioinfomatics

Research Areas

• Informatics, Human interfaces and interactions
• Informatics, Database science

Papers

• Human retroviral antisense mRNAs are retained in the nuclei of infected cells for viral persistence

  Guangyong Ma; Jun-ichirou Yasunaga; Kazuya Shimura; Keiko Takemoto; Miho Watanabe; Masayuki Amano; Hirotomo Nakata; Benquan Liu; Xiaorui Zuo; Masao Matsuoka

  Proceedings of the National Academy of Sciences, 27 Apr. 2021, Peer-reviewed

  
• Effects of activation of the LINE-1 antisense promoter on the growth of cultured cells

  Tomoyuki Honda; Yuki Nishikawa; Kensuke Nishimura; Da Teng; Keiko Takemoto; Keiji Ueda

  Scientific Reports, Dec. 2020, Peer-reviewed

  
• Identification of a Retroelement-Containing Human Transcript Induced in the Nucleus by Vaccination

  Tomoyuki Honda; Keiko Takemoto; Keiji Ueda

  International Journal of Molecular Sciences, Jun. 2019, Peer-reviewed

  
• A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing

  Masaki Kato; Keiko Takemoto; Yoichi Shinkai

  Nature Communications, Apr. 2018, Peer-reviewed

  Access this paper :

  
• HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT)

  Keiko Yasuma; Jun-ichirou Yasunaga; Keiko Takemoto; Kenji Sugata; Yuichi Mitobe; Norihiro Takenouchi; Masanori Nakagawa; Yutaka Suzuki; Masao Matsuoka

  PLOS PATHOGENS, Jan. 2016, Peer-reviewed

  Access this paper :

  
• Identification of TIGIT as an HBZ-induced gene by genome-wide analyses: its association with evasion of host defense

  Keiko Yasuma; Jun-ichirou Yasunaga; Keiko Takemoto; Kenji Sugata; Norihiro Takenouchi; Masanori Nakagawa; Yutaka Suzuki; Masao Matsuoka

  RETROVIROLOGY, Aug. 2015, Peer-reviewed

  
• Essential roles of the histone methyltransferase ESET in the epigenetic control of neural progenitor cells during development

  Siok-Lay Tan; Miyuki Nishi; Toshiyuki Ohtsuka; Toshiyuki Matsui; Keiko Takemoto; Asuka Kamio-Miura; Hiroyuki Aburatani; Yoichi Shinkai; Ryoichiro Kageyama

  DEVELOPMENT, Oct. 2012, Peer-reviewed

  
• ESET-mediated endogenous retrovirus silencing.

  Tan S; Takemoto K; Matsui T; Kageyama R; Shinkai Y

  63rd Fujihara Seminar 京都, 2012 年7月31 日, 2012, Peer-reviewed

  
• Developmental changes in the spatial expression of genes involved in myosin function in Dictyostelium

  M Maeda; H Kuwayama; M Yokoyama; K Nishio; T Morio; H Urushihara; M Katoh; Y Tanaka; T Saito; H Ochiai; K Takemoto; H Yasukawa; Takeuchi, I

  DEVELOPMENTAL BIOLOGY, Jul. 2000, Peer-reviewed

  
• Evolutionary instability of operon structures disclosed by sequence comparisons of complete microbial genomes

  T Itoh; K Takemoto; H Mori; T Gojobori

  MOLECULAR BIOLOGY AND EVOLUTION, Mar. 1999, Peer-reviewed

  
• Large-scale analysis of Dictyostelium cDNA : toward understanding the mechanism of multicellular organization

  MORIO,Takahiro; URUSHIHARA,Hideko; MIZUNO,Hideaki; YOSHINO,Ryuji; MITRA,Biswa Nath; PI,Min; SATO,Tomihiro; SAITO,Tamao; OCHIAI,Hiroshi; YOSHIDA,Motonobu; YASUKAWA,Hiroo; UGAWA,Yoshihiro; TAKEMOTO,Keiko; WILLIAMS,Feffrey; MAEDA,Miniko; TAKEUCHI,Ikuo; TANAKA,Yoshimasa

  日本分子生物学会年会プログラム・講演要旨集, Dec. 1998

  
• 多細胞体構築機構のゲノム的基礎 : 細胞性粘菌cDNAの大規模解析

  MITRA,Biswa Nath; PI,Min; WILLIAMS,Jeffrey

  日本植物学会大会研究発表記録 = Proceedings of the annual meeting of the Botanical Society of Japan, Sep. 1998

  
• The Dictyostelium developmental cDNA project: Generation and analysis of expressed sequence tags from the first-finger stage of development

  Takahiro Morio; Hideko Urushihara; Tamao Saito; Yoshihiro Ugawa; Hideaki Mizuno; Motonobu Yoshida; Ryuji Yoshino; Biswa Nath Mitra; Min Pi; Tomihiro Sato; Keiko Takemoto; Hiroo Yasukawa; Jeffrey Williams; Mineko Maeda; Ikuo Takeuchi; Hiroshi Ochiai; Yoshimasa Tanaka

  DNA Research, 1998, Peer-reviewed

  
• Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features

  Yoshihiro Yamamoto; Hiroji Aiba; Tomoya Baba; Kouji Hayashi; Toshifumi Inada; Katumi Isono; Takeshi Itoh; Sigenobu Kimura; Masanari Kitagawa; Kozo Makino; Takeyoshi Miki; Nobutaka Mitsuhashi; Kiyoshi Mizobuchi; Hirotada Mori; Shinsuke Nakade; Yoshikazu Nakamura; Hiroko Nashimoto; Taku Oshima; Satoshi Oyama; Noriko Saito; Gen-Ichi Sampei; Yu-Ji Satoh; Suharnan Sivasundaram; Hideaki Tagami; Hideyuki Takahashi; Jun-Ichi Takeda; Keiko Takemoto; Kazuyuki Uehara; Chieko Wada; Sayaka Yamagata; Takashi Horiuchi

  DNA Research, 1997, Peer-reviewed

  
• A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map

  T. Oshima; H. Aiba; T. Baba; K. Fujita; K. Hayashi; A. Honjo; K. Ikemoto; T. Inada; T. Itoh; M. Kajihara; K. Kanai; K. Kashimoto; S. Kimura; M. Kitagawa; K. Makino; S. Masuda; T. Miki; K. Mizobuchi; H. Mori; K. Motomura; Y. Nakamura; H. Nashimoto; Y. Nishio; N. Saito; G.-I. Sampei; Y. Seki; H. Tagami; K. Takemoto; C. Wada; Y. Yamamoto; M. Yano; T. Horiuchi

  DNA Research, 1996, Peer-reviewed

  
• A 570-kb DNA sequence of the escherichia coli K-12 genome corresponding to the 28.0-40.1 min region on the linkage map

  H. Aiba; T. Baba; K. Hayashi; T. Inada; K. Isono; T. Itoh; H. Kasai; K. Kashimoto; S. Kimura; M. Kitakawa; M. Kitagawa; K. Making; T. Miki; K. Mizobuchi; H. Mori; T. Mori; K. Motomura; S. Nakade; Y. Nakamura; H. Nashimoto; Y. Nishio; T. Oshima; N. Saito; G.-I. Sampei; Y. Seki; S. Sivasundaram; H. Tagami; J.-I. Takeda; K. Takemoto; Y. Takeuchi; C. Wada; Y. Yamamoto; T. Horiuchi

  DNA Research, 1996, Peer-reviewed

  
• A 460-kb DNA sequence of the escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map

  T. Itoh; H. Aiba; T. Baba; K. Hayashi; T. Inada; K. Isono; H. Kasai; S. Kimura; M. Kitakawa; M. Kitagawa; K. Making; T. Miki; K. Mizobuchi; H. Mori; T. Mori; K. Motomura; S. Nakade; Y. Nakamura; H. Nashimoto; Y. Nishio; T. Oshima; N. Saito; G.-I. Sampei; Y. Seki; S. Sivasundaram; H. Tagami; J.-I. Takeda; K. Takemoto; C. Wada; Y. Yamamoto; T. Horiuchi

  DNA Research, 1996, Peer-reviewed

  
• CAMP REGULATION OF THE EXPRESSION OF PRESPORE-SPECIFIC GENES, SP96 AND DP87, IN DISAGGREGATED SLUG CELLS OF DICTYOSTELIUM-DISCOIDEUM

  K TAKEMOTO; TAKEUCHI, I; M TASAKA

  CELL DIFFERENTIATION AND DEVELOPMENT, Aug. 1990, Peer-reviewed

  
• THE ORIGIN OF PRESPORE VACUOLES IN DICTYOSTELIUM-DISCOIDEUM CELLS AS ANALYZED BY ELECTRON-MICROSCOPIC IMMUNOCYTOCHEMISTRY AND AUTORADIOGRAPHY

  K TAKEMOTO; A YAMAMOTO; TAKEUCHI, I

  JOURNAL OF CELL SCIENCE, 1985, Peer-reviewed

  

Misc.

• Mechanism for endogenous retrovirus silencing and innate immune responses

  TAKEMOTO Keiko

  第41回日本分子生物学会年会, Nov. 2018

  
• Mechinism for endogenous retrovirus silencing in MEF by histone methyltransferase Setdb1

  Keiko Takemoto; Masaki Kato; Yoichi Shinkai

  Annual meeting of the Molecular Biology, Dec. 2017

  
• Silencing of endogenous retroviruses (ERVs) mediated by Setdb1

  Masaki Kato; Keiko Takemoto; Siok-Lay Tan; Ryoichiro Kageyama; Yoichi Shinkai

  GENES & GENETIC SYSTEMS, Dec. 2015

  
• セルトリ細胞の成熟とそのエピゲノム変化の解析

  竹本 経緯子

  平成26年度酵素学研究拠点共同利用・共同研究報告書, Jul. 2015

  
• 内在性レトロウイルスのエピジェネティックな発現制御と配列特異性

  竹本 経緯子

  NGS現場の会第4回研究会 ポスター発表, 2015

  
• Silencing of endogenous retroviruses (ERVs) mediated by SetDB/Eset

  Masaki KATO; Keiko TAKEMOTO; Siok-Lay TAN; Ryoichiro KAGEYAMA; Yoichi SHINKAI

  RIKEN EPIGENETICS in KOBE, Feb. 2014

  
• H3K9メチル化による内在性レトロウイルスの制御

  竹本 経緯子

  NGS現場の会第3回研究会ポスター発表, Sep. 2013

  
• Roles of ESET in epigenetic regulation of developing cortex.

  SiokLay Tan; Miyuki Nichi; Toshiyuki Ohtsuka; Toshiyuki Matsui; Keiko Takemoto; Asuka Miura-Kamio; Hiroyuki Aburatani; Yoichi Shinkai; Ryoichiro Kageyama

  RIKEN CDB Symposium “Epigenetic Landscape in Development and Diseases", 神戸, 3月14日-3月16日, 2011., 2011, Peer-reviewed

  
• 大腸菌ゲノムにおけるオペロン構造の解析

  竹本経緯子; 伊藤剛; 森浩禎

  日本分子生物学会年会プログラム・講演要旨集, Dec. 1997, Peer-reviewed

  
• 微生物ゲノムにおけるオペロン構造の保存性の比較

  伊藤剛; 竹本経緯子; 森浩禎; 五条堀孝

  日本遺伝学会大会プログラム・予稿集, Nov. 1997, Peer-reviewed

  
• Sequence Analysis of Escherichia coli Genome

  竹本 経緯子

  E. coli and Small Genomes,, 1997, Peer-reviewed

  
• Evolutionary Instability of Operon Structures in Complete Microbial Genomes

  竹本 経緯子

  Annual meeting of the Genetics society of Japan,, 1997, Peer-reviewed

  
• Analysis of Operon Structure in E. coli Genome

  竹本 経緯子

  Annual meeting of the Molecular Biology society of Japan,, 1997, Peer-reviewed

  
• 類似性による大腸菌ORFのグループ化及び他種バクテリアとの比較

  竹本 経緯子

  第19回日本分子生物会学会ポスター発表,, 1996, Peer-reviewed

  
• 大腸菌ゲノム解析の現状

  竹本 経緯子

  第19回日本分子生物学会ポスター発表,, 1996, Peer-reviewed

  
• Clustering and Evolutional Analysis of E. coli Proteins

  竹本 経緯子

  Genome Informatics Workshop,, 1996, Peer-reviewed

  
• 大腸菌ゲノムにおけるオペロンの構造機能解析

  竹本経為子; 矢野実; 伊藤剛; 梶原美和子; 森浩禎

  日本分子生物学会年会プログラム・講演要旨集, Nov. 1995, Peer-reviewed

  
• 大腸菌ゲノムにおけるオペロンの構造機能解析

  竹本 経緯子

  第18回日本分子生物学会ポスター発表,, 1995, Peer-reviewed

  
• Clustering of all known and predicted open reading frames of Escherichia coli K12.

  竹本 経緯子

  Proceedings Genome Informatics Workshop,, 1995, Peer-reviewed

  
• 大腸菌ゲノムプロジェクトの現状-染色体0-12分領域の構造

  竹本 経緯子

  第17回日本分子生物学会ポスター発表,, 1994, Peer-reviewed

  
• Construction and analysis of Escherichia coli genome database

  竹本 経緯子

  Genome Informatics Workshop,, 1994, Peer-reviewed

  

Works

• 第16回日本分子生物学会ポスター発表:大腸菌デノムデータベースの構築

  From 1993

  
• 第31回生物物理学会 口頭発表:大腸菌ゲノムデータベースの構築:DNAデータベースの整理及び整列化

  From 1993

  
• Annual meeting of the Molecular Biology society of Japan ; Constraction of Escherichia coli genome database

  From 1993

  
• Annual meeting of the Biophysical society of Japan ; Constraction of Escherichia coli genome database ; Compilation of DNA sequence data

  From 1993

  

External funds: Kakenhi

• Elucidating the significance of amplified expression of endogenous retrotransposon in autoimmune/autoinflammatory diseases

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49030:Experimental pathology-related

  The University of Tokyo

  Takuma Shibata

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  TLR7;トランスポゾン;自己炎症性疾患;自己免疫疾患;細胞増殖;レトロトランスポゾン;Toll Like Receptor;内在性レトロトランスポゾン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03451/
• Molecular mechanism of epigenetic regulation of mammalian sex differentiation

  Grant-in-Aid for Scientific Research (A)

  The University of Tokushima

  Makoto TACHIBANA

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  ヒストン;メチル化;性決定;ヒストン修飾;エピジェネティクス;性分化;エピゲノム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26250037/

External funds: others

• Construction of database for Escherichia coli genome
• Dictyostelium discoideum cDNA project

Administration

School management (title, position)

• From 01 Apr. 2009

  情報セキュリティ技術責任者
• From 01 Apr. 2011, To 31 Mar. 2013

  情報環境機構KUINS利用負担金検討委員会　委員
• 部局情報システム技術責任者
• 部局情報システム連絡責任者
• KUINS利用負担金検討委員会　委員

Faculty management (title, position)

• From 01 Apr. 2010, To 31 Mar. 2012

  情報セキュリティ委員会　委員
• From 01 Apr. 2011, To 31 Mar. 2017

  人権委員会　委員
• From 01 Apr. 2014

  情報セキュリティ委員会　委員