Basic Information

Academic Degree

• 修士（工学）(京都大学)
• 博士（生命科学）(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院工学研究科修士課程合成・生物化学専攻, 修了
• 京都大学, 大学院生命科学研究科博士課程高次生命科学専攻, 修了

Research History

• From Dec. 2020, To Present

  Kyoto University Graduate School of Biostudies, Associate Professor
• From Dec. 2020, To Present

  Hokkaido University Faculty of Medicine, Visiting Scholar
• From Nov. 2014, To Nov. 2020

  Stanford University, Visiting Scholar/ Visiting Faculty
• From Apr. 2020, To Nov. 2020

  Hokkaido University, Faculty of Medicine, Lecturer
• From Nov. 2016, To Mar. 2020

  Hokkaido University, GI-CoRE/ Faculty of Medicine, Lecturer
• From Apr. 2015, To Nov. 2016

  Hokkaido University, GI-CoRE/ Faculty of Medicine, Assistant Professor
• From May 2010, To Mar. 2015

  Hokkaido University, Faculty of Medicine, Project Assistant Professor
• From Feb. 2008, To May 2010

  Lawrence Berkeley National Laboratory, Postdoctoral Fellow
• From Oct. 2007, To Jan. 2008

  Osaka Bioscience Institute, JSPS Researcher
• From Apr. 2007, To Aug. 2007

  Osaka Bioscience Institute, Researcher

researchmap URL

• https://researchmap.jp/Rab_2021

Research

Research Interests

• Lysosome
• Cell-to-cell communications
• Vesicle trafficking
• Radiation biology
• Cancer invasion/Metastasis
• Tumor microenvironment

Research Areas

• Life sciences, Radiology
• Life sciences, Medical biochemistry
• Life sciences, Cell biology
• Life sciences, Molecular biology

Papers

• Phosphorylation of annexin A2 at serine 25 is required for endothelin-1 stimulated cell proliferation and AKT activation in melanoma cells

  Mazaki Y; Horinouchi T; Onodera Y; Nam JM

  Biochem Biophys Res Commun, Jan. 2025, Peer-reviewed, Last author

  
• The lipid-binding D4 domain of perfringolysin O facilitates the active loading of exogenous cargo into extracellular vesicles

  Opadele AE; Nishioka S; Wu PH; Le QT; Shirato H; Nam JM*; Onodera Y*

  FEBS Letters, Feb. 2024, Peer-reviewed, Corresponding author

  
• Angiogenic inhibitor pre-administration improves the therapeutic effects of immunotherapy.

  Sato M; Maishi N; Hida Y; Yanagawa-Matsuda A; Alam MT; Sakakibara-Konishi J; Nam JM; Onodera Y; Konno S; Hida K

  Cancer Medicine, 19 Feb. 2023, Peer-reviewed

  
• The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation

  Yu L; Maishi N; Akahori E; Hasebe A; Takeda R; Matsuda AY; Hida Y; Nam JM; Onodera Y; Kitagawa Y; Hida K

  Cancer Science, 23 Aug. 2022, Peer-reviewed

  
• The oxidized-LDL/LOX-1 axis in tumor endothelial cells enhances metastasis by recruiting neutrophils and cancer cells

  Tsumita T; Maishi N; Annan DA; Alam MT; Matsuda A; Onodera Y; Nam JM; Hida Y; Hida K

  Int J Cancer, Sep. 2022, Peer-reviewed

  
• A Consistent Protocol Reveals a Large Heterogeneity in the Biological Effectiveness of Proton and Carbon-Ion Beams for Various Sarcoma and Normal-Tissue-Derived Cell Lines.

  Yagi M; Takahashi Y; Minami K; Matsuura T; Nam JM; Onodera Y; Akagi T; Maeda T; Okimoto T; Shirato H; Ogawa K

  Cancers, Apr. 2022, Peer-reviewed

  
• Proteolysis of a histone acetyl reader, ATAD2, induces chemoresistance of cancer cells under severe hypoxia by inhibiting cell cycle progression in S phase.

  Haitani T; Kobayashi M; Koyasu S; Akamatsu S; Suwa T; Onodera Y; Nam JM; Nguyen PTL; Menju T; Date H; Ogawa O; Harada H

  Cancer Lett., Mar. 2022, Peer-reviewed

  
• SPINK1 as a plasma marker for tumor hypoxia and a therapeutic target for radiosensitization

  Suwa T; Kobayashi M; Shirai Y; Nam JM; Tabuchi Y; Takeda N; Akamatsu S; Ogawa O; Mizowaki T; Hammond EM; Harada H

  JCI Insight, 08 Nov. 2021, Peer-reviewed

  Access this paper :

  
• Tumor microenvironment and radioresistance

  Suwa T, Kobayashi M, Nam JM, Harada H

  Experimental & Molecular Medicine, 16 Jun. 2021, Peer-reviewed

  
• An Overview of the Recent Development of Anticancer Agents Targeting the HIF‐1 Transcription Factor

  Shirai Y; Chow CC; Kambe G; Suwa T; Kobayashi M; Takahashi I; Harada H; Nam JM

  Cancers, Jun. 2021, Peer-reviewed, Last author, Corresponding author

  
• Inhibition of stromal biglycan promotes normalization of the tumor microenvironment and enhances chemotherapeutic efficacy

  Cong L; Maishi N; Annan DA; Young MF; Morimoto H; Morimoto M; Nam JM; Hida Y; Hida Y

  Breast Cancer Research, May 2021, Peer-reviewed

  
• Lysosomal trafficking mediated by Arl8b and BORC promotes invasion of cancer cells that survive radiation

  Wu PH; Onodera Y*; Giaccia AJ; Le QT; Shimizu S; Shirato H; Nam JM*

  Communications Biology, Dec. 2020, Peer-reviewed, Last author, Corresponding author

  
• The impact of dose delivery time on biological effectiveness in proton irradiation with various biological parameters.

  Kasamatsu K; Matsuura T; Tanaka S; Takao S; Miyamoto N; Nam JM; Shirato H; Shimizu S; Umegaki K

  Medical physics, 11 Jul. 2020, Peer-reviewed

  
• Rab27b contributes to radioresistance and exerts a paracrine effect via epiregulin in glioblastoma

  Nishioka S; Wu PH; Yakabe T; Giaccia AJ; Le QT; Aoyama H; Shimizu S; Shirato H; Onodera Y*; Nam JM*

  Neuro-Oncology Advances, 01 Jan. 2020, Peer-reviewed, Last author, Corresponding author

  
• Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment

  Annan, DA; Maishi, N; Soga T; Dawood; R. Li, C; Kikuchi, H; Hojo, T; Morimoto, M; Kitamura, T; Alam, MT; Minowa, K; Shinohara, N; Nam, JM; Hida, Y; Hida, K

  Cell Communication and Signaling, 19 Dec. 2019, Peer-reviewed

  
• Targeting Integrins in Cancer Nanomedicine: Applications in Cancer Diagnosis and Therapy

  Wu PH; Opadele AE; Onodera Y*; Nam JM*

  Cancers, 13 Nov. 2019, Peer-reviewed, Last author, Corresponding author

  
• Lambda-Carrageenan Enhances the Effects of Radiation Therapy in Cancer Treatment by Suppressing Cancer Cell Invasion and Metastasis through Racgap1 Inhibition

  Wu PH; Onodera Y; Recuenco FC; Giaccia AJ; Le QT; Shimizu S; Shirato H; Nam JM

  Cancers, 16 Aug. 2019, Peer-reviewed, Last author, Corresponding author

  
• Endothelin type B receptor interacts with 78-kDa glucose-regulated protein

  Mazaki Y; Higashi T; Onodera Y; Nam JM; Hashimoto A; Hashimoto S; Horinouchi T; Miwa S

  FEBS Letters, Mar. 2019, Peer-reviewed

  
• Arf6-driven cell invasion is intrinsically linked to TRAK1-mediated mitochondrial anterograde trafficking to avoid oxidative catastrophe.

  Onodera Y; Nam JM; Horikawa M; Shirato H; Sabe H

  Nature Communications, Jul. 2018, Peer-reviewed

  
• Toll-like receptor 3 signal augments radiation-induced tumor growth retardation in a murine model

  Yoshida S; Shime H; Takeda Y; Nam JM; Takashima K; Matsumoto M; Shirato H; Kasahara M; Seya T

  Cancer Science, 01 Apr. 2018, Peer-reviewed

  
• Cell competition with normal epithelial cells promotes apical extrusion of transformed cells through metabolic changes

  Shunsuke Kon; Kojiro Ishibashi; Hiroto Katoh; Sho Kitamoto; Takanobu Shirai; Shinya Tanaka; Mihoko Kajita; Susumu Ishikawa; Hajime Yamauchi; Yuta Yako; Tomoko Kamasaki; Tomohiro Matsumoto; Hirotaka Watanabe; Riku Egami; Ayana Sasaki; Atsuko Nishikawa; Ikumi Kameda; Takeshi Maruyama; Rika Narumi; Tomoko Morita; Yoshiteru Sasaki; Ryosuke Enoki; Sato Honma; Hiromi Imamura; Masanobu Oshima; Tomoyoshi Soga; Jun-ichi Miyazaki; Michael R. Duchen; Jin-Min Nam; Yasuhito Onodera; Shingo Yoshioka; Junichi Kikuta; Masaru Ishii; Masamichi Imajo; Eisuke Nishida; Yoichiro Fujioka; Yusuke Ohba; Toshiro Sato; Yasuyuki Fujita

  NATURE CELL BIOLOGY, May 2017, Peer-reviewed

  
• Nik-related kinase regulates trophoblast proliferation and placental development by modulating AKT phosphorylation

  Morioka Y; Nam JM; Ohashi T

  PLoS ONE, Feb. 2017, Peer-reviewed

  
• Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells

  Wu PH; Onodera Y; Ichikawa Y; Rankin EB; Giaccia AJ; Watanabe Y; Qian W; Hashimoto T; Shirato H; Nam JM*

  Interntional Journal of Nanomedicine, 2017, Peer-reviewed, Last author, Corresponding author

  
• High expression of EPB41L5, an integral component of the Arf6-driven mesenchymal program, correlates with poor prognosis of squamous cell carcinoma of the tongue

  Otsuka Y; Sato H; Oikawa T; Onodera Y; Nam JM; Hashimoto A; Fukunaga K; Hatanaka KC; Hatanaka Y; Matsuno Y; Fukuda S; Sabe H

  Cell Communication and Signaling, Nov. 2016, Peer-reviewed

  
• The Rho guanine nucleotide exchange factor ARHGEF5 promotes tumor malignancy via epithelial-mesenchymal transition

  Y. Komiya; Y. Onodera; M. Kuroiwa; S. Nomimura; Y. Kubo; J. M. Nam; K. Kajiwara; S. Nada; C. Oneyama; H. Sabe; M. Okada

  Oncogenesis, Sep. 2016, Peer-reviewed

  
• Hypoxia: Signaling the Metastatic Cascade

  Rankin EB; Nam JM; Giaccia AJ

  Trends in Cancer, 01 Jun. 2016, Peer-reviewed

  
• Evaluation of the relative biological effectiveness of spot-scanning proton irradiation in vitro

  Maeda K; Yasui H; Matsuura T; Yamamori T; Suzuki M; Nagane M; Nam JM; Inanami O; Shirato H

  Journal of Radiation Research, Jun. 2016, Peer-reviewed

  
• P53-and mevalonate pathway-driven malignancies require Arf6 for metastasis and drug resistance

  Hashimoto A; Oikawa T; Hashimoto S; Sugino H; Yoshikawa A; Otsuka Y; Handa H; Onodera Y; Nam JM; Oneyama C; Okada M; Fukuda M; Sabe H

  Journal of Cell Biology, Apr. 2016, Peer-reviewed

  
• Increased sugar uptake promotes oncogenesis via EPAC/RAP1 and O-GlcNAc pathways

  Onodera Y; Nam JM; Bissell MJ

  Journal of Clinical Investigation, Jan. 2014, Peer-reviewed

  
• Intracellular trafficking of integrins in cancer cells

  Onodera Y; Nam JM; Sabe H

  Pharmacology & Therapeutics, Oct. 2013, Peer-reviewed

  
• Co-Overexpression of GEP100 and AMAP1 Proteins Correlates with Rapid Local Recurrence after Breast Conservative Therapy

  Kinoshita R; Nam JM; Ito YM; Hatanaka KC; Hashimoto A; Handa H; Otsuka Y; Hashimoto S; Onodera Y; Hosoda M; Onodera S; Shimizu S; Tanaka S; Shirato H; Tanino M; Sabe H

  PLoS ONE, Oct. 2013, Peer-reviewed

  
• β1-integrin via NF-κB signaling is essential for acquisition of invasiveness in a model of radiation treated in situ breast cancer

  Jin-Min Nam; Kazi M. Ahmed; Sylvain Costes; Hui Zhang; Yasuhito Onodera; Adam B. Olshen; Kanako C. Hatanaka; Rumiko Kinoshita; Masayori Ishikawa; Hisataka Sabe; Hiroki Shirato; Catherine C. Park

  Breast Cancer Research, 25 Jul. 2013, Peer-reviewed, Lead author

  
• Rab5c promotes AMAP1-PRKD2 complex formation to enhance beta 1 integrin recycling in EGF-induced cancer invasion

  Yasuhito Onodera; Jin-Min Nam; Ari Hashimoto; Jim C. Norman; Hiroki Shirato; Shigeru Hashimoto; Hisataka Sabe

  JOURNAL OF CELL BIOLOGY, Jun. 2012, Peer-reviewed

  
• Breast Cancer Cells in Three-dimensional Culture Display an Enhanced Radioresponse after Coordinate Targeting of Integrin alpha 5 beta 1 and Fibronectin

  Nam JM; Onodera Y; Bissell MJ; Park CC

  Cancer Research, Jul. 2010, Peer-reviewed, Lead author

  
• The EGFR-GEP100-Arf6-AMAP1 Signaling Pathway Specific to Breast Cancer Invasion and Metastasis(dagger)

  Sabe H; Hashimoto S; Morishige M; Ogawa E; Hashimoto A; Nam JM; Miura K; Yano H; Onodera Y

  Traffic, Aug. 2009, Peer-reviewed

  
• EphA2 Engages Git1 to Suppress Arf6 Activity Modulating Epithelial Cell-Cell Contacts

  Miura K; Nam JM; Kojima C; Mochizuki N; Sabe H

  Molecular Biology of the Cell, Apr. 2009, Peer-reviewed

  
• beta 1 integrin targeting to enhance radiation therapy

  Nam JM; Chung Y; Hsu HC; Park CC

  International Journal of Radiation Biology, 2009, Peer-reviewed, Lead author

  
• [Breast neoplasms: invasion and metastasis].

  Onodera Y; Nam JM

  Nihon Rinsho. Japanese journal of clinical medicine, Jun. 2007, Peer-reviewed

  
• CIN85, a Cbl-interacting protein, is a component of AMAP1-mediated breast cancer invasion machinery

  Nam JM; Onodera Y; Mazaki Y; Miyoshi H; Hashimoto S; Sabe H

  EMBO Journal, Feb. 2007, Peer-reviewed, Lead author

  
• Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2

  Mazaki Y; Hashimoto S; Tsujimura T; Morishige M; Hashimoto A; Aritake K; Yamada A; Nam JM; Kiyonari H; Nakao K; Sabe H

  Nature Immunology, Jul. 2006, Peer-reviewed

  
• Construction of engineered yeast with the ability of binding to cellulose

  Nam JM; Fujita Y; Arai T; Kondo A; Morikawa Y; Okada H; Ueda M; Tanaka A

  Journal of Molecular Catalysis B-Enzymatic, Jun. 2002, Peer-reviewed, Lead author

  

Misc.

• 分泌因子を介した細胞外コミュニケーションによるがん治療抵抗性のメカニズム がんの治療抵抗性における分泌因子の役割

  西岡蒼一郎; 有光妃斗美; 小野寺康仁; NAM Jin-Min

  化学と生物, 2023

  
• Radiation-induced intracellular trafficking and secretory factors

  NAM Jin-Min; 小野寺康仁; WU Ping-Hsiu; 西岡蒼一郎; 白土博樹

  放射線生物研究, 2022

  
• エンドセリンB受容体はGRP78と相互作用する

  真崎雄一; 東恒仁; 堀之内孝広; 橋本あり; 橋本茂; 南ジンミン; 小野寺康仁

  日本分子生物学会年会プログラム・要旨集(Web), 2018

  
• Gold Nanoparticles With RGD Peptide in Radiation Therapy Suppress the Invasion Activity of Breast Cancer Cells

  P. H. Wu; Y. Onodera; Y. Ichikawa; Y. Watanabe; W. Qian; T. Hashimoto; H. Shirato; J. M. Nam

  INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Oct. 2016

  
• Arf6-AMAP1経路によるROS制御は乳癌の放射線抵抗性に寄与する

  小野寺 康仁; 南 ジンミン; 及川 司; 白土 博樹; 佐邊 壽孝

  日本癌学会総会記事, Oct. 2015

  
• 放射線照射後の乳腺上皮細胞の3次元構造維持に関わる分子機序の解析

  南 ジンミン; 小野寺 康仁; 佐邊 壽孝; 白土 博樹

  日本癌学会総会記事, Oct. 2015

  
• SLD repair impact on prolonged proton irradiation with various cell specific parameters

  KASAMATSU Koki; MATSUURA Taeko; MATSUURA Taeko; TAKAO Seishin; TAKAO Seishin; TANAKA Sodai; TANAKA Sodai; MIYAMOTO Naoki; MIYAMOTO Naoki; NAM Jin-Min; SHIRATO Hiroki; SHIRATO Hiroki; UMEGAKI Kikuo; UMEGAKI Kikuo

  日本医学物理学会学術大会報文集, 2020

  
• がん細胞における小胞輸送経路を介したミトコンドリア分布制御と活性酸素および放射線への耐性

  小野寺康仁; 南ジンミン; 白土博樹; 佐邊壽孝

  日本放射線影響学会大会抄録(Web), 2016

  
• Arf6-AMAP1経路によるROS制御は乳癌の放射線抵抗性に寄与する

  小野寺 康仁; 南 ジンミン; 及川 司; 白土 博樹; 佐邊 壽孝

  日本癌学会総会記事, Oct. 2015

  
• 放射線照射後の乳腺上皮細胞の3次元構造維持に関わる分子機序の解析

  南 ジンミン; 小野寺 康仁; 佐邊 壽孝; 白土 博樹

  日本癌学会総会記事, Oct. 2015

  
• The invasion activity after radiation treatment is suppressed by RGD peptide conjugated gold nanoparticles in breast cancer cells

  P. Wu; Y. Onodera; Y. Ichikawa; Y. Watanabe; W. Qian; T. Hashimoto; H. Shirato; J. Nam

  MOLECULAR BIOLOGY OF THE CELL, 2015

  
• 糖代謝と小胞輸送の相互作用を介したがん形質の誘導

  小野寺康仁; 南ジンミン; 白土博樹; BISSELL Mina; 佐邊壽孝

  がんと代謝研究会プログラム&抄録集, 2015

  
• Arf6-AMAP1経路による酸化還元状態の恒常性維持は乳癌の放射線抵抗性に寄与する(Robust redox homeostasis mediated by Arf6-AMAP1 pathway confers resistance to ionizing radiation in breast cancer)

  小野寺 康仁; 南 ジンミン; 及川 司; 白土 博樹; 佐邊 壽孝

  日本癌学会総会記事, Sep. 2014

  
• 乳癌における放射線照射後の浸潤能獲得過程に関わる分子機序の解析(Analysis of molecular mechanism involved in invasiveness of radiation treated breast cancer cells)

  南 ジンミン; 小野寺 康仁; 佐邊 壽孝; 白土 博樹

  日本癌学会総会記事, Sep. 2014

  
• 癌放射線治療への分子生物学的アプローチ 変異p53が放射線抵抗性に根幹的な間葉型浸潤経路を創出する機構(Toward the improvement of radiotherapy: Approaches from the molecular biological point of view Mechanisms by which oncogenic mutant-p53 generates mesenchymal invasive pathway pivotal to a radiation resis

  佐邊 壽孝; 橋本 あり; 橋本 茂; 小野寺 康仁; 及川 司; Nam Jin-Min; 小根山 千歳; 杉野 弘和; 吉河 歩; 大塚 勇太郎; 半田 悠; 芳野 正修; 岡田 雅人

  日本癌学会総会記事, Oct. 2013

  
• 放射線照射後の乳癌再発に関わるシグナルの解析(Possible mechanisms of non-invasive to invasive phenotypic conversion of breast cancer cells upon radiation)

  南 ジンミン; 小野寺 康仁; 石川 正純; 佐邊 壽孝; 白土 博樹

  日本癌学会総会記事, Oct. 2013

  
• Targeting integrin signaling suppresses invasive recurrence in a three-dimensional model of radiation treated ductal carcinoma in situ

  J-M Nam; K. M. Ahmed; S. Costes; H. Zhang; H. Sabe; H. Shirato; C. C. Park

  CANCER RESEARCH, Dec. 2012

  
• Co-overexpression of GEP100 With EGFR Correlates With Early Recurrence After Breast Conservation Therapy (BCT)

  R. Kinoshita; J. Nam; M. Hosoda; C. Kubota K; M. Tanino; A. Hashimoto; Y. M. Ito; S. Tanaka; H. Sabe; H. Shirato

  INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Nov. 2012

  
• Targeting Beta-1 Integrin Suppresses Invasive Recurrence in a 3-dimensional Model of Radiation Treated Ductal Carcinoma In situ

  J. Nam; K. M. Ahmed; S. Costes; H. Zhang; H. Sabe; H. Shirato; C. C. Park

  INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Nov. 2012

  
• 非浸潤性乳管癌の3次元培養細胞モデルにおける放射線の影響と再発に関わる分子機序の解析(Targeting integrin suppresses invasive recurrence in a 3D model of radiation treated ductal carcinoma in situ)

  南 ジンミン; Kazi Ahmed; Sylvain Costes; Hui Zhang; 佐邊 壽孝; 白土 博樹; Catherine Park

  日本癌学会総会記事, Aug. 2012

  
• 乳癌浸潤に中枢的なArf6経路は変異p53により創出される(Mutant-p53 generates GEP100-Arf6-AMAP1 pathway to promote breast cancer cell invasiveness in response to TGFbeta1)

  橋本 あり; 橋本 茂; 吉河 歩; 杉野 弘和; 半田 悠; 味藤 静; 佐藤 宏紀; 大塚 勇太郎; 芳野 日南子; 南 ジンミン; 小野寺 康仁; 佐邊 壽孝

  日本癌学会総会記事, Aug. 2012

  
• 癌浸潤におけるAMAP1-PRKD2複合体によるインテグリンリサイクリングとその制御機構(beta1 integrin recycling via AMAP1-PRKD2 complex regulated by small GTPases in cancer invasion)

  小野寺 康仁; 南 ジンミン; 橋本 あり; 白土 博樹; 橋本 茂; 佐邊 壽孝

  日本癌学会総会記事, Aug. 2012

  
• 変異p53が癌浸潤転移シグナル経路を創出し活性化する

  橋本あり; 橋本茂; 吉河歩; 杉野弘和; 半田悠; 木下留美子; 畑中佳奈子; 三上修治; 谷野美智枝; 味藤静; 佐藤宏紀; 佐藤宏紀; 大塚勇太郎; 芳野日南子; 加戸由加里; NAM Jin-Min; 小野寺康仁; 田中伸哉; 白土博樹; 佐邊壽孝

  日本分子生物学会年会プログラム・要旨集(Web), 2012

  
• EGF刺激による乳癌細胞浸潤におけるAMAP1の詳細な作用機構(AMAP1 promotes β1 integrin recycling via PRKD2 and Rab5c in EGF-induced invasion of breast cancer cells)

  小野寺 康仁; 南 ジンミン; 橋本 茂; 橋本 あり; 白土 博樹; 佐邊 壽孝

  日本癌学会総会記事, Sep. 2011

  
• 変異p53はArf6活性化経路を介した浸潤獲得形質に必須である(Mutant p53 is essential for TGFβ1-induced breast cancer cell invasiveness via activation of GEP100-Arf6-AMAP1 pathway)

  橋本 あり; 橋本 茂; 大塚 勇太郎; 吉河 歩; 杉野 弘和; 半田 悠; 南 ジンミン; 佐藤 宏紀; 福田 諭; 小野寺 康仁; 佐邊 壽孝

  日本癌学会総会記事, Sep. 2011

  
• 癌の悪性化における糖代謝と小胞輸送の役割(Glucose metabolism and intracellular trafficking in tumor malignancy)

  小野寺 康仁; 南 ジンミン; 橋本 茂; 橋本 あり; 佐邊 壽孝; Bissell Mina

  日本細胞生物学会大会講演要旨集, May 2011

  
• TGFβ1はGEP100-Arf6-AMAP1経路の活性化によりEMTを誘導し、この活性化は癌幹細胞性と関連する(TGFβ1 activates GEP100-Arf6-AMAP1 pathway to induce EMT, and possible relationship of this activation to cancer stemness)

  橋本 あり; 平野 真理子; 谷野 美智枝; 梅本 勉; 小野寺 康仁; 佐藤 宏紀; 木下 留美子; 南 ジンミン; 大塚 勇太郎; 福田 諭; 白土 博樹; 相沢 慎一; 橋本 茂; 田中 伸哉; 佐邊 壽孝

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010

  
• EphA2受容体によるArf6の不活性化と上皮細胞間の接着制御(EphA2 engages Git1 to suppress Arf6 activity and modulate epithelial cell-cell contacts)

  三浦 浩一; Nam Jin-Min; 児島 千恵; 望月 直樹; 佐邊 壽孝

  日本生化学会大会プログラム・講演要旨集, Sep. 2009

  
• セマフォリンシグナル伝達とエフリンシグナル伝達に関する最新の知見 上皮細胞間接触を制御するArf6のGit1による抑制におけるEphA2の関与(Recent advances in semaphorin signaling and ephrin signaling EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts)

  三浦 浩一; Nam Jin-Min; 児島 千恵; 望月 直樹; 佐邊 壽孝

  日本細胞生物学会大会講演要旨集, May 2009

  
• a5b1 integrin mediates survival of breast cancer cells in 3-dimensional culture that can be specifically targeted for therapy

  J-M Nam; H. J. Zhang; Y. Chung; C. C. Park

  CANCER RESEARCH, Jan. 2009

  
• Alpha5beta1 Integrin and Oncofetal Fibronectin are Upregulated in Malignant Breast Cells in Three-dimensional Culture That can be Specifically Targeted for Radiation Therapy

  J. Nam; C. C. Park

  INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2009

  
• 濃度勾配性因子による細胞極性・細胞運動の制御 組織構築、創傷治癒およびがんの浸潤・転移の機構解明を目指して 乳癌浸潤転移におけるEGFR-GEP100-Arf6-AMAP1経路 微小環境との相互作用

  佐邊 壽孝; 橋本 茂; 森重 真毅; 橋本 あり; 小川 栄二; 矢野 元; Nam Jinmin; 小野寺 康仁

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Nov. 2008

  
• 癌浸潤転移における細胞運動のメカニズム 血管新生と癌浸潤に共通なシグナル経路(Molecular mechanisms of cell migration in cancer invasion and metastasis Common usage of an Arf6-GEP100 signaling pathway in angiogenesis and tumor invasion)

  橋本 あり; 橋本 茂; 小川 栄治; 廣瀬 まゆみ; 高島 成二; 森重 真毅; 毛受 暁史; 南 ジンミン; 真崎 雄一; 北風 政史; 渋谷 正史; 佐邊 壽孝

  日本細胞生物学会大会講演要旨集, Jun. 2008

  
• 乳癌浸潤転移におけるEGFR‐GEP100‐Arf6‐AMAP1経路:微小環境との相互作用

  佐邊壽孝; 橋本茂; 森重真毅; 橋本あり; 小川栄二; 矢野元; NAM Jinmin; 小野寺康仁

  生化学, 2008

  
• Git1は、Arf6活性化E-cadherin誘発細胞接着を抑制するために、Nckを介してリガンド活性化EphA2と結合する(Git1 links to ligand-activated EphA2 via Nck to suppress Arf6 activity modulatinq E-cadherin-mediated cell-cell contacts)

  三浦 浩一; Nam Jin-Min; 佐邊 壽孝

  日本癌学会総会記事, Aug. 2007

  
• 癌浸潤及び血管新生におけるArf6活性化の意義(Common usage of Arf6-signaling pathway in tumor invasion and angiogenesis)

  橋本 あり; 南 ジンミン; 森重 真毅; 毛受 暁史; 橋本 茂; 渋谷 正史; 佐邊 壽孝

  日本癌学会総会記事, Aug. 2007

  
• CIN85, a Cbl-interacting multiadaptor protein, is a component of AMAP1-mediated breast cancer invasion machinery.

  J. Nam; Y. Onodera; Y. Mazaki; H. Miyoshi; S. Hashimoto; H. Sabe

  Nat. Immunol., 2007

  
• 乳癌細胞の浸潤におけるAMAP1のユビキチン化の役割(Property of AMAP1 to be monoubiquitinated via binding with CIN85 and Cbl is crucial for breast cancer invasive activity)

  Nam Jin-Min; 小野寺 康仁; 橋本 茂; 佐邊 壽孝

  日本癌学会総会記事, Sep. 2006

  

Books and Other Publications

• がんの放射線治療とインテグリンシグナル

  南璡旼; 山川 健介; OPADELE Emmanuel Abayomi; 呉 秉修; 白𡈽 博樹; 小野寺 康仁

  放射線生物研究, Jun. 2023

  
• 分泌因子を介した細胞外コミュニケーションによるがん治療抵抗性のメカニズム

  西岡蒼一郎; 有光妃斗美; 小野寺康仁; 南璡旼

  化学と生物, May 2023

  
• Invasion/Metastasis

  Yasuhito Onodera; Jin-Min NAM

  日本臨床, 2007

  
• リソソームとがん浸潤

  南ジンミン,呉ピンシユウ; 小野寺康仁

  生体の科学, Jun. 2022

  
• 放射線影響による細胞外微小環境のリモデリングを担う小胞輸送のメカニズムの解明

  南璡旼

  放影協ニュース, Apr. 2022

  
• 放射線により誘導される細胞内小胞輸送と分泌因子

  南璡旼; 小野寺康仁; 吳秉修; 西岡蒼一郎; 白𡈽博樹

  放射線生物研究, Dec. 2021

  

Awards

• 16 Sep. 2022

  日本放射線影響学会, 日本放射線影響学会女性研究者顕彰・岩崎民子賞

  「放射線影響による細胞外コミュニケーションを担う小胞輸送のメカニズム」

  南 璡旼

  放射線科学の領域で継続的に研究活動を行い、その研究活動によって放射線科学領域の研究の活性化と日本放射線影響学会の発展に顕著な貢献をした女性研究者に対して授与される。
• 25 Feb. 2022

  放射線影響協会, 放射線影響研究奨励賞

  「放射線影響による細胞外微小環境のリモデリングを担う小胞輸送メカニズムの解明」

  南 璡旼

  放射線科学研究の分野において活発な研究活動を行い、将来性のある若手研究者に対して授与される。

External funds: Kakenhi

• がんの治療抵抗性を克服する～分泌因子と細胞間相互作用を標的にしたアプローチ～

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))

  Basic Section 52040:Radiological sciences-related

  Kyoto University

  Nam JinMin

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  がん;浸潤;分泌因子;小胞輸送;細胞間コミュニケーション

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21KK0278/
• Analysis of cell-to-cell communication to identify novel targets of radiotherapy

  Grant-in-Aid for Scientific Research (C)

  Basic Section 52040:Radiological sciences-related

  Kyoto University;Hokkaido University

  Jin-Min Nam

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  放射線;小胞輸送;パラクライン;細胞間コミュニケーション;エクソソーム;がん細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K08140/
• Research and development about helium and proton hybrid system with proton CT and Immuno-radiotherapy

  Grant-in-Aid for Scientific Research (B)

  Basic Section 52040:Radiological sciences-related

  Hokkaido University

  白土 博樹

  From 01 Apr. 2019, To 31 Mar. 2024, Granted

  陽子線;ヘリウム線;免疫賦活照射;低LET;PD-1機能;ヘリウム線治療;陽子線CT;免疫放射線治療;4次元分割照射;ヘリウム;PD-L1阻害;PD-1;免疫賦活;リアルタイム適合照射

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03591/
• Molecular targets to suppress microenvironment changes and invasive cancer recurrence after radiotherapy

  Grant-in-Aid for Scientific Research (C)

  Hokkaido University

  JinMin Nam

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  放射線;癌浸潤;小胞輸送;インテグリン;がん微小環境;がん細胞;浸潤;癌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10380/
• Radiosensitization by mitochondrial ROS amplification

  Grant-in-Aid for Young Scientists (A)

  Hokkaido University

  Yasuhito Onodera

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  ミトコンドリア;活性酸素;放射線;小胞輸送;インテグリン;活性酸素種;がん

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H05674/
• Possible molecular mechanisms of normal cells and invasive breast cancer cells after radiation treatment

  Grant-in-Aid for Young Scientists (B)

  Hokkaido University

  JINMIN NAM

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  放射線;乳癌;３次元培養;3次元培養

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25861050/
• Analysis of the molecular mechanism of radiation induced invasiveness

  Grant-in-Aid for Young Scientists (B)

  Hokkaido University

  JinMin NAM

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  放射線;乳癌;浸潤;インテグリン;3次元培養

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791376/
• Research for Real-time Tracking Medical Science

  Grant-in-Aid for Scientific Research (A)

  Hokkaido University

  Hiroki SHIRATO

  From 01 Apr. 2009, To 31 Mar. 2013, Project Closed

  放射線治療;動体追跡;医学研究;生体の動き;細胞遊走;胃癌;低酸素細胞;量子線シミュレーション;電子線トラック解析;モンテカルロ法;プラスチック檢出器;体幹部定位放射線照射;非線形最適化;プラスチック検出器

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21249065/
• 放射線治療効果向上を目指した新規細胞標的～インフルエンサー・セルの探索～

  Grant-in-Aid for Scientific Research (B)

  Basic Section 52040:Radiological sciences-related

  Kyoto University

  Nam JinMin

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  がん;小胞輸送;がん微小環境;細胞外コミュニケーション;分泌因子;放射線治療;細胞間コミュニケーション

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H03023/
• Optimization of cancer treatment based on intra-tumor metabolic geometry

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

  Medium-sized Section 50:Oncology and related fields

  Hokkaido University

  小野寺 康仁

  From 07 Oct. 2021, To 31 Mar. 2026, Granted

  放射線治療;がん代謝;代謝協調;微小環境;代謝;放射線;細胞間相互作用

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21KK0140/
• Mechanisms of altered glycosylation and increased radioresistance due to metabolic heterogeneity within tumors

  Grant-in-Aid for Scientific Research (B)

  Basic Section 52040:Radiological sciences-related

  Hokkaido University

  小野寺 康仁

  From 01 Apr. 2023, To 31 Mar. 2027, Granted

  放射線治療;がん代謝;糖鎖

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02847/
• 放射線治療効果向上を目指した新規細胞標的～インフルエンサー・セルの探索～

  Grant-in-Aid for Scientific Research (B)

  Basic Section 52040:Radiological sciences-related

  Kyoto University

  Nam JinMin

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  がん;小胞輸送;がん微小環境;細胞外コミュニケーション;分泌因子;放射線治療;細胞間コミュニケーション

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24284/
• Mechanisms of altered glycosylation and increased radioresistance due to metabolic heterogeneity within tumors

  Grant-in-Aid for Scientific Research (B)

  Basic Section 52040:Radiological sciences-related

  Hokkaido University

  小野寺 康仁

  From 01 Apr. 2023, To 31 Mar. 2027, Granted

  放射線;糖代謝;相互作用;糖鎖修飾;放射線治療;がん代謝;糖鎖

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27538/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Experiments in Systemic Life Sciences

  5013, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Experiments in Systemic Life Sciences

  5013, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Molecular and Cell Biology I

  1016, Spring, Graduate School of Biostudies, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Experiments in Systemic Life Sciences

  5013, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Experiments in Systemic Life Sciences

  5013, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Molecular and Cell Biology I

  1016, Spring, Graduate School of Biostudies, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Experiments in Systemic Life Sciences

  5013, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Molecular and Cell Biology I

  1016, Spring, Graduate School of Biostudies, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Experiments in Systemic Life Sciences

  5013, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From Apr. 2021, To Mar. 2022

  Advanced Molecular and Cell Biology I

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科

Part-time lecturer

• From 01 Aug. 2023, To 30 Sep. 2023

  北海道大学
• From 01 Aug. 2022, To 31 Aug. 2022

  北海道大学, 医理工学院

Administration

Faculty management (title, position)

• From 01 Apr. 2023, To 31 Mar. 2025

  医学図書館図書連絡委員会
• From 01 Apr. 2023

  ダイバーシティ推進委員会
• From 01 Apr. 2022

  人権委員会
• From 01 Apr. 2021, To 31 Mar. 2023

  男女共同参画推進アクションプラン推進委員会　委員
• From 01 Apr. 2021, To 31 Mar. 2023

  医学図書館図書連絡委員会　委員