Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医学専攻 基礎病態学講座病態生物医学分野, 教授

Faculty

• 医学部

Concurrent Affiliation

• Institute for Advanced Study, 物質－細胞統合システム拠点, 連携主任研究者

Professional Memberships

• JAPAN SOCIETY FOR CELL BIOLOGY
• THE JAPANESE SOCIETY OF PATHOLOGY
• 日本ウイルス学会
• 日本癌学会
• 日本生化学会

Academic Degree

• 1987

  Doctor of Phylosopy(The University of Tokyo)

Academic Resume (Graduate Schools)

• The University of Tokyo, Graduate School of Medicine, Division of the The Third Basic Medicine, 修了

Academic Resume (Undergraduate School/Majors)

• The University of Tokyo, Faculty of Medicine, School of Medicine, MD

Research History

• From May 2024, To Present

  CMIC HOLDINGS Co., LTD, Scientific advisor
• From Apr. 2024, To Present

  Kyoto University Graduate School of Medicine, Visiting Professor
• From Apr. 2024, To Present

  Kyoto University Graduate School of Biostudies, Researcher
• From Sep. 2021, To Present

  国立研究開発法人国立循環器病センター, 共創研究育成センター, 建都イメージングサポート拠点長
• From Nov. 2020, To Present

  国立研究開発法人国立循環器病センター, 客員部長
• From Apr. 2018, To Mar. 2023

  Graduate School of Biostudies, Kyoto University, Research Center for Dynamic Living Systems, Director
• From Apr. 2007, To Mar. 2024

  Graduate School of Biostudies, Kyoto University, Laboratory of Bioimaging and Cell Signaling, Professor
• From Apr. 2006, To Mar. 2024

  Kyoto University Graduate School of Medicine, Department of Pathology and Biology of Diseases, Professor
• From Jan. 2001, To Mar. 2006

  Research Institute for Microbial Diseases, Tumor Virology, Professor
• From Oct. 1996, To Dec. 2000

  International Medical Center Japan Research Institute, Department of Pathology, Director
• From Apr. 1996, To Sep. 1996

  National Institute of Infectious Disease, Department of Infectious Pathology, Laboratory Head
• From Apr. 1992, To Mar. 1996

  National Institute of Infectious Disease, Department of Infectious Pathology, Senior Researcher
• From Apr. 1987, To Mar. 1992

  National Institute of Health, Department of Pathology, Researcher
• From Sep. 1988, To Aug. 1990

  The Rockefeller University, Research Assistant

Profile

• Profile

  http://www.fret.lif.kyoto-u.ac.jp/

Language of Instruction

• Japanese
• English

ID,URL

• J-Global ID

  200901048294489836

Website(s) (URL(s))

• http://www.fret.lif.kyoto-u.ac.jp/

researchmap URL

• https://researchmap.jp/michiyuki_matsuda

Research

Research Topics, Overview of the research

• Research Topics

  Our goal is to create a virtual cell, in which we can simulate intracellular signal transduction cascades.

• Overview of the research

  We are visualizing the growth signal trasduction cascades in living cells by using probes based on the principle of Foster resonance energy transfer (FRET). The FRET biosensors are extremely powerful to visualize the spatio-temporal regulation of signal transduction network within cells and to analyze the activities of individual cells within tissues. These FRET videos are also processed to extract parameters that characterize the property of each signaling molecule. We use these parameters obtained in living cells to build kinetic simulation models of growth signal transduction cascades.

Research Areas

• Life sciences, Cell biology, Cell Biology
• Life sciences, Experimental pathology, Experimental Pathology

Papers

• ATP dynamics as a predictor of future podocyte structure and function after acute ischemic kidney injury in female mice

  Masahiro Takahashi; Shinya Yamamoto; Shigenori Yamamoto; Akihiro Okubo; Yasuaki Nakagawa; Koichiro Kuwahara; Taiji Matsusaka; Shingo Fukuma; Masamichi Yamamoto; Michiyuki Matsuda; Motoko Yanagita

  Nature Communications, 22 Nov. 2024

  
• Low-affinity ligands of the epidermal growth factor receptor are long-range signal transmitters during collective cell migration of epithelial cells

  Eriko Deguchi; Shuhao Lin; Daiki Hirayama; Kimiya Matsuda; Akira Tanave; Kenta Sumiyama; Shinya Tsukiji; Tetsuhisa Otani; Mikio Furuse; Alexander Sorkin; Michiyuki Matsuda; Kenta Terai

  26 Sep. 2024

  
• Interplay between medial nuclear stalling and lateral cellular flow underlies cochlear duct spiral morphogenesis

  Mamoru Ishii; Tomoko Tateya; Michiyuki Matsuda; Tsuyoshi Hirashima

  25 Jul. 2020

  
• 【蛍光タンパク質センサー】赤色蛍光タンパクでのFRETプローブ開発

  寺井 健太; 松田 道行

  細胞, Apr. 2023

  
• がん研究におけるイメージング技術の新展開 FRETバイオセンサーを用いた癌研究 情報伝達分子のゆらぎが癌細胞の多様性をもたらす(New development of imaging technique in cancer research Cancer research with FRET biosensors: Fluctuation of signaling molecules causes heterogeneity of cancer cells)

  松田 道行; 幸長 弘子

  日本癌学会総会記事, Oct. 2013

  
• FRETバイオセンサーを用いた癌細胞のトランスクリプトーム解析(Transcriptome of Glioblastoma Cells Sorted with FRET Biosensors)

  幸長 弘子; 平田 英周; 村口 輝行; 平尾 敦; 程 久美子; 松田 道行

  日本細胞生物学会大会講演要旨集, May 2010

  
• 【生体イメージングの最前線-絶え間ない技術革新と生命医科学の新展開】技術・機器の進歩 マウス生体内イメージングに向けたツール開発

  寺井 健太; 松田 道行

  医学のあゆみ, Jul. 2023

  
• 【蛍光タンパク質センサー】赤色蛍光タンパクでのFRETプローブ開発

  寺井 健太; 松田 道行

  細胞, Apr. 2023

  
• MDCK細胞の集団遊走および増殖におけるErbBファミリー受容体の機能の重畳性(Redundant roles of ErbB-family receptors in the collective cell migration and cell growth of MDCK cells)

  松田 樹生也; 平山 大記; 林 抒豪; 真流 玄武; 青木 一洋; 寺井 健太; 日野 直也; 松田 道行

  日本細胞生物学会大会講演要旨集, Jun. 2021

  
• プロテインキナーゼA活性の細胞間制御機構の解析

  渡部 哲也; 寺井 健太; 松田 道行

  日本細胞生物学会大会講演要旨集, Jun. 2020

  
• MDCK細胞系におけるERK活性の伝搬と細胞集団運動に必須のEGFリガンド(EGF ligands are essential for ERK activation wave propagation and collective cell migration in MDCK cell line)

  Lin Shuhao; 日野 直也; 真流 玄武; 岩本 亮; 青木 一洋; 寺井 健太; 松田 道行

  日本細胞生物学会大会講演要旨集, Jun. 2020

  
• がん微小環境におけるインターフェロンγシグナル伝達の生体内イメージング

  田中 泰生; 寺井 健太; 松田 道行

  日本細胞生物学会大会講演要旨集, Jun. 2020

  
• 局所損傷における好中球遊走の生体イメージング

  中西 彬; 松田 道行; 寺井 健太

  日本病理学会会誌, Mar. 2020

  
• がん組織の生体イメージング: 現場を押さえろ! 肺毛細血管におけるNK細胞による転移腫瘍排除過程の可視化(In vivo microscopy of cancer tissues: catch the scene! Visualization of NK cell-mediated elimination of metastatic tumor cells in the pulmonary capillaries)

  一瀬 大志; 寺井 健太; 松田 道行

  日本癌学会総会記事, Sep. 2019

  
• NK細胞におけるERK活性は標的細胞の殺傷に必要である(ERK activation in NK cells is required for killing the target cells)

  一瀬 大志; 寺井 健太; 松田 道行

  日本癌学会総会記事, Sep. 2018

  
• MAGI-1 is required for Rap1 activation upon cell-cell contact and for enhancement of vascular endothelial cadherin-mediated cell adhesion

  A Sakurai; S Fukuhara; A Yamagishi; K Sako; Y Kamioka; M Masuda; Y Nakaoka; N Mochizuki

  MOLECULAR BIOLOGY OF THE CELL, Feb. 2006, Peer-reviewed

  
• Selective inhibition of vascular endothelial growth factor receptor-2 (VEGXR-2) identifies a central role for VEGFR-2 in human aortic endothelial cell responses to VEGF

  A Endo; S Fukuhara; M Masuda; T Ohmori; N Mochizuki

  JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION, 2003, Peer-reviewed

  
• Calcium transients trigger switch-like discharge of prostaglandin E2 in an extracellular signal-regulated kinase-dependent manner

  Tetsuya Watabe; Shinya Yamahira; Kanako Takakura; Dean Thumkeo; Shuh Narumiya; Michiyuki Matsuda; Kenta Terai

  eLife, 26 Jan. 2024

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• Calcium transients trigger switch-like discharge of prostaglandin E2 in an extracellular signal-regulated kinase-dependent manner

  Tetsuya Watabe; Shinya Yamahira; Kanako Takakura; Dean Thumkeo; Shuh Narumiya; Michiyuki Matsuda; Kenta Terai

  eLife, 08 Jan. 2024

  
• Visual quantification of prostaglandin E₂ discharge from a single cell

  Tetsuya Watabe; Shinya Yamahira; Michiyuki Matsuda; Kenta Terai

  Cell Structure and Function, 2023

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• ERK-mediated curvature feedback regulates branching morphogenesis in lung epithelial tissue

  Tsuyoshi Hirashima; Michiyuki Matsuda

  Current Biology, Feb. 2024

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• Visualization of protein kinase activities in living cells

  Aoki, K.; Komatsu, N.; Goto, A.; Matsuda, M.

  Neuromethods, 2012

  
• Activation of Rap1, antagonist to Ras, by Crk C3G

  Hattori, S.; Matsuda, M.

  Japanese Journal of Cancer and Chemotherapy, 1997

  
• The 3rd German-Japanese Joint Workshop. Cell Death in the CNS: Molecules and Programs

  Müller, W.E.G.; Romero, F.J.; Perg; e, G.; Perovic, S.; Graeber, M.B.; Kösel, S.; Egensperger, R.; Schnopp, N.M.; Mehraein, P.; Miura, M.; Okada, M.; Von Holst, A.; Lefcort, F.B.; Rodriguez-Tébar, A.; Michaille, J.-J.; Dhouailly, D.; Bäckström, A.; Ebendal, T.; Rohrer, H.; Sendtner, M.; Michaelidis, T.; Gravel, C.; Götz, R.; Ochs, G.; Toyka, K.V.; Thoenen, H.; Egensperger, R.; Kösel, S.; Mehraein, P.; Graeber, M.B.; Homma, S.; Oppenheim, R.W.; Kwak, S.; Heumann, R.; Narz, F.; Algür, Y.; Bartsch, D.; Hüser, M.; Klinz, F.-J.; Wagner, E.; Berns, H.; Obst, K.; Wahle, P.; Tanaka, H.; Nakamura, M.; Fukushima, M.; Ohta, K.; Jones, L.L.; Banati, R.B.; Raivich, G.; Kreutzberg, G.W.; Reiter, C.; Nie, Z.; Fischbach, K.-F.; Eguchi, Y.; Shimizu, S.; Tsujimoto, Y.; Davies, A.M.; Adu, J.; Middleton, G.; Kuchino, Y.; Kitanaka, C.; Sugiyama, A.; Asai, A.; Gold, R.; Hartung, H.-P.; Matsuoka, I.; Kobayashi, M.; Fujii, M.; Kurihara, K.; Suda, T.; Tanaka, M.; Adachi, M.; Nagata, S.; Hattori, S.; Matsuda, M.; Nakamura, S.; Hamanoue, M.; Machide, M.; Matsumoto, K.; Nakamura, T.; Nakajima, K.; Kohsaka, S.; Wanaka, A.; Imaizumi, K.; Tsuda, M.; Imai, Y.; Tohyama, M.; Takagi, T.; Barde, Y.-A.; Mannherz, H.G.; Rauch, F.; Zanotti, S.; Stephan, H.; Paddenberg, R.; Polzar, B.; Engelmann, H.; Hess, S.; Gottfried, E.

  Journal of Brain Research, 1996

  
• Production of monoclonal antibodies specific to the carboxyl terminal region of the 85 kDa subunit of phosphatidylinositol 3‐kinase: Use of the antibodies in recognition of mutant p85

  DADUANG, S.; NAGATA, S.; MATSUDA, M.; YAMORI, T.; ONODERA, K.; FUKUI, Y.

  Immunology and Cell Biology, 1995

  
• Biological and biochemical activity of v-Crk chimeras containing the SH2/SH3 regions of phosphatidylinositol-specific phospholipase C-γ and Src

  Matsuda, M.; Reichman, C.T.; Hanafusa, H.

  Journal of Virology, 1992

  
• Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins

  Matsuda, M.; Mayer, B.J.; Hanafusa, H.

  Molecular and Cellular Biology, 1991

  
• Binding of transforming protein, P47gag-crk, to a broad range of phosphotyrosine-containing proteins

  Matsuda, M.; Mayer, B.J.; Fukui, Y.; Hanafusa, H.

  Science, 1990

  
• Purification and characterization of P47gag-crk expressed in insect cells

  Matsuda, M.; Marshall, C.P.; Hanafusa, H.

  Journal of Biological Chemistry, 1990

  
• Host range bias of the JC virus mutant enhancer with DNA rearrangement

  Shinohara, T.; Matsuda, M.; Yasui, K.; Yoshiike, K.

  Virology, 1989

  
• Local activation of Rap1 contributes to directional vascular endothelial cell migration accompanied by extension of microtubules on which RAPL, a Rap1-associating molecule, localizes

  H Fujita; S Fukuhara; A Sakurai; A Yamagishi; Y Kamioka; Y Nakaoka; M Masuda; N Mochizuki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2005, Peer-reviewed

  
• EphA4-mediated rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells

  H Ogita; S Kunimoto; Y Kamioka; H Sawa; M Masuda; N Mochizuki

  CIRCULATION RESEARCH, Jul. 2003

  
• Knockout of all ErbB-family genes delineates their roles in proliferation, survival, and migration.

  Kimiya Matsuda; Daiki Hirayama; Naoya Hino; Sota Kuno; Asako Sakaue-Sawano; Atsushi Miyawaki; Michiyuki Matsuda; Kenta Terai

  Journal of cell science, 31 Jul. 2023

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• Stretching the limits of extracellular signal-related kinase (ERK) signaling - Cell mechanosensing to ERK activation.

  Tsuyoshi Hirashima; Naoya Hino; Kazuhiro Aoki; Michiyuki Matsuda

  Current opinion in cell biology, 11 Aug. 2023

  
• Dispensable role of Rac1 and Rac3 after cochlear hair cell specification

  Takashi Nakamura; Hirofumi Sakaguchi; Hiroaki Mohri; Yuzuru Ninoyu; Akihiro Goto; Taro Yamaguchi; Yoshitaka Hishikawa; Michiyuki Matsuda; Naoaki Saito; Takehiko Ueyama

  Journal of Molecular Medicine, 19 May 2023

  
• Biliverdin reductase-A遺伝子欠損による近赤外蛍光タンパク質高輝度化とビリベルジン要求性光遺伝学ツールの光応答性上昇

  小鉢 健樹; 隅山 健太; 松田 道行; 寺井 健太

  日本細胞生物学会大会講演要旨集, Jun. 2020

  
• 組織細胞間コミュニケーションのライブイメージングに資する細胞形態マーカー発現マウスの作成

  今西 彩子; 小松 直貴; 隅山 健太; 松田 道行

  日本細胞生物学会大会講演要旨集, May 2016

  
• In vivo FRET Imaging 分子活性と細胞動態を同時に観察する新しい研究手法

  松田 道行; 水野 礼; 平塚 拓也; 隅山 健太; 坂井 義治; 上岡 裕治

  日本免疫学会総会・学術集会記録, Nov. 2014

  
• Generation of transgenic mice expressing a FRET biosensor, SMART, that responds to necroptosis.

  Shin Murai; Kanako Takakura; Kenta Sumiyama; Kenta Moriwaki; Kenta Terai; Sachiko Komazawa-Sakon; Takao Seki; Yoshifumi Yamaguchi; Tetuo Mikami; Kimi Araki; Masaki Ohmuraya; Michiyuki Matsuda; Hiroyasu Nakano

  Communications biology, 05 Dec. 2022

  
• A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration.

  Naoya Hino; Kimiya Matsuda; Yuya Jikko; Gembu Maryu; Katsuya Sakai; Ryu Imamura; Shinya Tsukiji; Kazuhiro Aoki; Kenta Terai; Tsuyoshi Hirashima; Xavier Trepat; Michiyuki Matsuda

  Developmental cell, 26 Sep. 2022

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• cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells.

  Yuji Fukushima; Keiko Sakamoto; Michiyuki Matsuda; Yasunobu Yoshikai; Hideo Yagita; Daisuke Kitamura; Misaki Chihara; Nagahiro Minato; Masakazu Hattori

  Cell reports, 20 Sep. 2022

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• A FRET biosensor, SMART, monitors necroptosis in renal tubular epithelial cells in a cisplatin-induced kidney injury model

  Shin Murai; Kanako Takakura; Kenta Sumiyama; Kenta Moriwaki; Kenta Terai; Sachiko Komazawa-Sakon; Yoshifumi Yamaguchi; Tetuo Mikami; Kimi Araki; Masaki Ohmuraya; Michiyuki Matsuda; Hiroyasu Nakano

  Commun Biol, 19 Jun. 2022, Peer-reviewed

  
• 2P313 Efficient method for measuring dissociation rates between epidermal growth factor receptor and adaptor proteins in living cells(Native and artificial biomembranes-signal transduction,Poster Presentations)

  Morimatsu Miki; Matsuda Michiyuki

  Seibutsu Butsuri, 2007

  
• Function of the CT10 Retrovirus-Encoded v-crk On-cogene and its Human Homolog.

  Matsuda Michiyuki

  Uirusu, 1994

  
• Visualizing the Signal Transduction in Living Cells

  KUROKAWA Kazuo; MATSUDA Michiyuki

  Seibutsu Butsuri, 25 Feb. 2002

  
• 3K1346 Identification of feedback loops regulating stochastic cell migration by FRET imaging and statistical signal processing(Cell biology 4,The 49th Annual Meeting of the Biophysical Society of Japan)

  Kunida Katsuyuki; Aoki Kazuhiro; Matsuda Michiyuki

  Seibutsu Butsuri, 2011

  
• 1P230 1C1355 Identification of molecular network based on FRET imaging and statistical signal processing in randomly migrating HT1080 cells(Cell biology,Oral Presentations,The 48th Annual Meeting of the Biophysical Society of Japan)

  Kunida Katsuyuki; Aoki Kazuhiro; Matsuda Michiyuki

  Seibutsu Butsuri, 2010

  
• Cell image segmentation by integrating multiple CNNs

  Yuki Hiramatsu; Kazuhiro Hotta; Ayako Imanishi; Michiyuki Matsuda; Kenta Terai

  IEEE Computer Society Conference on Computer Vision and Pattern Recognition Workshops, 13 Dec. 2018

  
• Segmentation of cell membrane and nucleus by improving Pix2pix

  Masaya Sato; Kazuhiro Hotta; Ayako Imanishi; Michiyuki Matsuda; Kenta Terai

  BIOSIGNALS 2018 - 11th International Conference on Bio-Inspired Systems and Signal Processing, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018, 2018

  
• Segmentation of cell membrane and nucleus using branches with different roles in deep neural network

  Tomokazu Murata; Kazuhiro Hotta; Ayako Imanishi; Michiyuki Matsuda; Kenta Terai

  BIOSIGNALS 2018 - 11th International Conference on Bio-Inspired Systems and Signal Processing, Proceedings; Part of 11th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2018, 2018

  
• Cell Image Segmentation by Integrating Multiple CNNs.

  Yuki Hiramatsu; Kazuhiro Hotta; Ayako Imanishi; Michiyuki Matsuda; Kenta Terai

  2018 IEEE Conference on Computer Vision and Pattern Recognition Workshops, 2018

  
• Segmentation of Cell Membrane and Nucleus using Branches with Different Roles in Deep Neural Network.

  Tomokazu Murata; Kazuhiro Hotta; Ayako Imanishi; Michiyuki Matsuda; Kenta Terai

  Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - Volume 4: BIOSIGNALS(BIOSIGNALS), 2018

  
• Segmentation of Cell Membrane and Nucleus by Improving Pix2pix.

  Masaya Sato; Kazuhiro Hotta; Ayako Imanishi; Michiyuki Matsuda; Kenta Terai

  Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2018) - Volume 4: BIOSIGNALS(BIOSIGNALS), 2018

  
• 1H1710 Lateral Propagation of EGF SIgnaling after Local Stimulation Is Dependent on Receptor Density

  Sawano-Sakaue A.; Takayama Shuichi; Matsuda M.; Miyawaki A.

  Seibutsu Butsuri, 2002

  
• C-type Natriuretic Peptide-induced PKA Activation Promotes Endochondral Bone Formation in Hypertrophic Chondrocytes.

  Keisho Hirota; Tsuyoshi Hirashima; Kazuki Horikawa; Akihiro Yasoda; Michiyuki Matsuda

  Endocrinology, 01 Mar. 2022, Peer-reviewed, Last author

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• Functional visualization of NK cell-mediated killing of metastatic single tumor cells.

  Hiroshi Ichise; Shoko Tsukamoto; Tsuyoshi Hirashima; Yoshinobu Konishi; Choji Oki; Shinya Tsukiji; Satoshi Iwano; Atsushi Miyawaki; Kenta Sumiyama; Kenta Terai; Michiyuki Matsuda

  eLife, 03 Feb. 2022, Peer-reviewed

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• Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration

  Shuhao Lin; Daiki Hirayama; Gembu Maryu; Kimiya Matsuda; Naoya Hino; Eriko Deguchi; Kazuhiro Aoki; Ryo Iwamoto; Kenta Terai; Michiyuki Matsuda

  Life Science Alliance, Jan. 2022, Peer-reviewed

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• A Dual Promoter System to Monitor IFN-γ Signaling in vivo at Single-cell Resolution.

  Taisei Tanaka; Yoshinobu Konishi; Hiroshi Ichise; Shinya Tsukiji; Michiyuki Matsuda; Kenta Terai

  Cell structure and function, 22 Dec. 2021, Peer-reviewed

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• Stalling interkinetic nuclear migration in curved pseudostratified epithelium of developing cochlea

  Mamoru Ishii; Tomoko Tateya; Michiyuki Matsuda; Tsuyoshi Hirashima

  Royal Society Open Science, Dec. 2021, Peer-reviewed

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• Two-photon AMPK and ATP imaging reveals the bias between rods and cones in glycolysis utility.

  Jiazhou He; Masamichi Yamamoto; Kenta Sumiyama; Yumi Konagaya; Kenta Terai; Michiyuki Matsuda; Shinya Sato

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Sep. 2021, Peer-reviewed

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• Intravital Imaging Identifies the VEGF-TXA2 Axis as a Critical Promoter of PGE2 Secretion from Tumor Cells and Immune Evasion.

  Yoshinobu Konishi; Hiroshi Ichise; Tetsuya Watabe; Choji Oki; Shinya Tsukiji; Yoko Hamazaki; Yasuhiro Murakawa; Akifumi Takaori-Kondo; Kenta Terai; Michiyuki Matsuda

  Cancer research, 01 Aug. 2021, Peer-reviewed, Last author

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• Retrograde ERK activation waves drive base-to-apex multicellular flow in murine cochlear duct morphogenesis.

  Mamoru Ishii; Tomoko Tateya; Michiyuki Matsuda; Tsuyoshi Hirashima

  eLife, 05 Mar. 2021, Peer-reviewed

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• Metastatic Single Tumor Cells Evade NK Cell-mediated Killing by Thrombin-mediated Loss of the Activating Ligand CD155/PVR/Necl-5

  Hiroshi Ichise; Shoko Tsukamoto; Tsuyoshi Hirashima; Yoshinobu Konishi; Choji Oki; Shinya Tsukiji; Satoshi Iwano; Atsushi Miyawaki; Kenta Sumiyama; Kenta Terai; Michiyuki Matsuda

  17 Jan. 2021

  
• Visualization of Spatially-Controlled Vasospasm by Sympathetic Nerve-Mediated ROCK Activation.

  Ayako Imanishi; Hiroshi Ichise; Chuyun Fan; Yasuaki Nakagawa; Koichiro Kuwahara; Kenta Sumiyama; Michiyuki Matsuda; Kenta Terai

  The American journal of pathology, Jan. 2021

  
• Spatiotemporal ATP Dynamics during AKI Predict Renal Prognosis.

  Shinya Yamamoto; Masamichi Yamamoto; Jin Nakamura; Akiko Mii; Shigenori Yamamoto; Masahiro Takahashi; Keiichi Kaneko; Eiichiro Uchino; Yuki Sato; Shingo Fukuma; Hiromi Imamura; Michiyuki Matsuda; Motoko Yanagita

  Journal of the American Society of Nephrology : JASN, Dec. 2020

  
• Single-Cell Activation of the cAMP-Signaling Pathway in 3D Tissues with FRET-Assisted Two-Photon Activation of bPAC.

  Tomoaki Kinjo; Tetsuya Watabe; Kenju Kobachi; Kenta Terai; Michiyuki Matsuda

  ACS chemical biology, 20 Nov. 2020

  
• Intravital imaging reveals cell cycle-dependent myogenic cell migration during muscle regeneration.

  Yumi Konagaya; Kanako Takakura; Maina Sogabe; Anjali Bisaria; Chad Liu; Tobias Meyer; Atsuko Sehara-Fujisawa; Michiyuki Matsuda; Kenta Terai

  Cell cycle (Georgetown, Tex.), Nov. 2020

  
• Rhodopsin-mediated light-off-induced protein kinase A activation in mouse rod photoreceptor cells.

  Shinya Sato; Takahiro Yamashita; Michiyuki Matsuda

  Proceedings of the National Academy of Sciences of the United States of America, 27 Oct. 2020

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• Altered G1 signaling order and commitment point in cells proliferating without CDK4/6 activity.

  Chad Liu; Yumi Konagaya; Mingyu Chung; Leighton H Daigh; Yilin Fan; Hee Won Yang; Kenta Terai; Michiyuki Matsuda; Tobias Meyer

  Nature communications, 20 Oct. 2020

  
• Biliverdin Reductase-A Deficiency Brighten and Sensitize Biliverdin-binding Chromoproteins.

  Kenju Kobachi; Sota Kuno; Shinya Sato; Kenta Sumiyama; Michiyuki Matsuda; Kenta Terai

  Cell structure and function, 21 Aug. 2020, Peer-reviewed

  
• Experimental pathology by intravital microscopy and genetically encoded fluorescent biosensors.

  Michiyuki Matsuda; Kenta Terai

  Pathology international, Jul. 2020

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• ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization.

  Naoya Hino; Leone Rossetti; Ariadna Marín-Llauradó; Kazuhiro Aoki; Xavier Trepat; Michiyuki Matsuda; Tsuyoshi Hirashima

  Developmental cell, 22 Jun. 2020, Peer-reviewed

  
• Engineering Orthogonal, Plasma Membrane-Specific SLIPT Systems for Multiplexed Chemical Control of Signaling Pathways in Living Single Cells.

  Akinobu Nakamura; Choji Oki; Kenya Kato; Satoko Fujinuma; Gembu Maryu; Keiko Kuwata; Tatsuyuki Yoshii; Michiyuki Matsuda; Kazuhiro Aoki; Shinya Tsukiji

  ACS chemical biology, 17 Apr. 2020

  
• Booster, a Red-Shifted Genetically Encoded Förster Resonance Energy Transfer (FRET) Biosensor Compatible with Cyan Fluorescent Protein/Yellow Fluorescent Protein-Based FRET Biosensors and Blue Light-Responsive Optogenetic Tools.

  Tetsuya Watabe; Kenta Terai; Kenta Sumiyama; Michiyuki Matsuda

  ACS sensors, 27 Mar. 2020, Peer-reviewed

  
• Serotonin 5-HT4 receptor boosts functional maturation of dendritic spines via RhoA-dependent control of F-actin.

  Yvonne Schill; Monika Bijata; Olga Kopach; Volodymyr Cherkas; Dalia Abdel-Galil; Katrin Böhm; Markus H Schwab; Michiyuki Matsuda; Valerie Compan; Subhadip Basu; Krystian Bijata; Jakub Wlodarczyk; Lucie Bard; Nicholas Cole; Alexander Dityatev; Andre Zeug; Dmitri A Rusakov; Evgeni Ponimaskin

  Communications biology, 14 Feb. 2020

  
• Indispensable role of STIL in the regulation of cancer cell motility through the lamellipodial accumulation of ARHGEF7-PAK1 complex.

  Hideaki Ito; Takumi Tsunoda; Miho Riku; Shingo Inaguma; Akihito Inoko; Hideki Murakami; Hiroshi Ikeda; Michiyuki Matsuda; Kenji Kasai

  Oncogene, Feb. 2020

  
• Incoherent Feedforward Regulation via Sox9 and ERK Underpins Mouse Tracheal Cartilage Development.

  Takuya Yoshida; Michiyuki Matsuda; Tsuyoshi Hirashima

  Frontiers in cell and developmental biology, 2020

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• Two Decades of Genetically Encoded Biosensors Based on Förster Resonance Energy Transfer.

  Kenta Terai; Ayako Imanishi; Chunjie Li; Michiyuki Matsuda

  Cell structure and function, 02 Nov. 2019

  
• 細胞・組織動態解析と数理モデルで解く形態形成の原理 多細胞のパターン形成のメカノケミカルフィードバックモデル

  平島 剛志; 日野 直也; 松田 道行

  日本生化学会大会プログラム・講演要旨集, Sep. 2019, Peer-reviewed

  
• FRET-assisted photoactivation of flavoproteins for in vivo two-photon optogenetics.

  Kinjo T; Terai K; Horita S; Nomura N; Sumiyama K; Togashi K; Iwata S; Matsuda M

  Nature methods, Sep. 2019, Peer-reviewed

  
• Divergent Dynamics and Functions of ERK MAP Kinase Signaling in Development, Homeostasis and Cancer: Lessons from Fluorescent Bioimaging

  Yu Muta; Michiyuki Matsuda; Masamichi Imajo; corresponding author

  Cancers, Apr. 2019, Peer-reviewed

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• An amphipathic helix of vinexin $α$ is necessary for a substrate stiffness-dependent conformational change in vinculin

  Hino Naoya; Ichikawa Takafumi; Kimura Yasuhisa; Matsuda Michiyuki; Ueda Kazumitsu; Kioka Noriyuki

  J Cell Sci, 2019, Peer-reviewed

  
• Single-cell quantification of the concentrations and dissociation constants of endogenous proteins

  Komatsubara, Akira T; Goto, Yuhei; Kondo, Yohei; Matsuda, Michiyuki; Aoki, Kazuhiro

  Journal of Biological Chemistry, 2019, Peer-reviewed

  
• Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine

  Yu Muta; Yoshihisa Fujita; Kenta Sumiyama; Atsuro Sakurai; M. Mark Taketo; Tsutomu Chiba; Hiroshi Seno; Kazuhiro Aoki; Michiyuki Matsuda; Masamichi Imajo

  Nature Communications, 01 Dec. 2018, Peer-reviewed

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• Dynamic MAPK/ERK Activity Sustains Nephron Progenitors through Niche Regulation and Primes Precursors for Differentiation.

  Anneliis Ihermann-Hella; Tsuyoshi Hirashima; Jussi Kupari; Kristen Kurtzeborn; Hao Li; Hyuk Nam Kwon; Cristina Cebrian; Abdul Soofi; Arvydas Dapkunas; Ilkka Miinalainen; Gregory R Dressler; Michiyuki Matsuda; Satu Kuure

  Stem cell reports, 09 Oct. 2018, Peer-reviewed

  
• Dynamic ERK signaling regulation in intestinal tumorigenesis

  Yu Muta; Michiyuki Matsuda; Masamichi Imajo

  Molecular & Cellular Oncology, Sep. 2018, Peer-reviewed

  
• PAR-3 controls endothelial planar polarity and vascular inflammation under laminar flow.

  Hikita T; Mirzapourshafiyi F; Barbacena P; Riddell M; Pasha A; Li M; Kawamura T; Brandes RP; Hirose T; Ohno S; Gerhardt H; Matsuda M; Franco CA; Nakayama M

  EMBO reports, Jul. 2018, Peer-reviewed

  
• A platform of BRET-FRET hybrid biosensors for optogenetics, chemical screening, and in vivo imaging.

  Naoki Komatsu; Kenta Terai; Ayako Imanishi; Yuji Kamioka; Kenta Sumiyama; Takashi Jin; Yasushi Okada; Takeharu Nagai; Michiyuki Matsuda

  Scientific reports, 12 Jun. 2018, Peer-reviewed

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• A novel morphological marker for the analysis of molecular activities at the single-cell level.

  Imanishi A; Murata T; Sato M; Hotta K; Imayoshi I; Matsuda M; Terai K

  Cell structure and function, Jun. 2018, Peer-reviewed

  
• Live-cell imaging with genetically encoded protein kinase activity reporters

  Gembu Maryu; Haruko Miura; Youichi Uda; Akira T. Komatsubara; Michiyuki Matsuda; Kazuhiro Aoki

  Cell Structure and Function, 2018, Peer-reviewed

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• Live-cell FRET imaging reveals a role of extracellular signal-regulated kinase activity dynamics in thymocyte motility

  Konishi Yoshinobu; Terai Kenta; Furuta Yasuhide; Kiyonari Hiroshi; Abe Takaya; Ueda Yoshihiro; Kinashi Tatsuo; Hamazaki Yoko; Takaori-Kondo Akifumi; Matsuda Michiyuki

  iScience, 2018, Peer-reviewed

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• Gliding basal cell migration of the urothelium during wound healing

  Sano, Takeshi; Kobayashi, Takashi; Ogawa, Osamu; Matsuda, Michiyuki

  The American journal of pathology, 2018, Peer-reviewed

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• Cell-to-cell heterogeneity in p38-mediated cross-inhibition of JNK causes stochastic cell death

  Miura Haruko; Kondo Yohei; Matsuda Michiyuki; Aoki Kazuhiro

  Cell reports, 2018, Peer-reviewed

  
• Propagating Wave of ERK Activation Orients Collective Cell Migration

  Kazuhiro Aoki; Yohei Kondo; Honda Naoki; Toru Hiratsuka; Reina E. Itoh; Michiyuki Matsuda

  DEVELOPMENTAL CELL, Nov. 2017, Peer-reviewed

  
• Genetically Encoded Tools for Optical Dissection of the Mammalian Cell Cycle

  Asako Sakaue-Sawano; Masahiro Yo; Naoki Komatsu; Toru Hiratsuka; Takako Kogure; Tetsushi Hoshida; Naoki Goshima; Michiyuki Matsuda; Hiroyuki Miyoshi; Atsushi Miyawaki

  MOLECULAR CELL, Nov. 2017, Peer-reviewed

  
• Efficient synthesis of phycocyanobilin in mammalian cells for optogenetic control of cell signaling

  Youichi Uda; Yuhei Goto; Shigekazu Oda; Takayuki Kohchi; Michiyuki Matsuda; Kazuhiro Aoki

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 2017, Peer-reviewed

  
• A Highly Sensitive FRET Biosensor for AMPK Exhibits Heterogeneous AMPK Responses among Cells and Organs

  Yumi Konagaya; Kenta Terai; Yusuke Hirao; Kanako Takakura; Masamichi Imajo; Yuji Kamioka; Norio Sasaoka; Akira Kakizuka; Kenta Sumiyama; Tomoichiro Asano; Michiyuki Matsuda

  CELL REPORTS, Nov. 2017, Peer-reviewed

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• Live imaging of extracellular signal-regulated kinase and protein kinase A activities during thrombus formation in mice expressing biosensors based on Forster resonance energy transfer

  T. Hiratsuka; T. Sano; H. Kato; N. Komatsu; M. Imajo; Y. Kamioka; K. Sumiyama; F. Banno; T. Miyata; M. Matsuda

  JOURNAL OF THROMBOSIS AND HAEMOSTASIS, Jul. 2017, Peer-reviewed

  
• Intravital Forster resonance energy transfer imaging reveals osteopontin-mediated polymorphonuclear leukocyte activation by tumor cell emboli

  Yuji Kamioka; Kanako Takakura; Kenta Sumiyama; Michiyuki Matsuda

  CANCER SCIENCE, Feb. 2017, Peer-reviewed

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• A FRET Biosensor for ROCK Based on a Consensus Substrate Sequence Identified by KISS Technology

  Chunjie Li; Ayako Imanishi; Naoki Komatsu; Kenta Terai; Mutsuki Amano; Kozo Kaibuchi; Michiyuki Matsuda

  CELL STRUCTURE AND FUNCTION, 2017, Peer-reviewed

  
• Cell Density-Dependent Increase in Tyrosine-Monophosphorylated ERK2 in MDCK Cells Expressing Active Ras or Raf

  Noriyuki Kawabata; Michiyuki Matsuda

  PLOS ONE, Dec. 2016, Peer-reviewed

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• Intravital imaging of mouse urothelium reveals activation of extracellular signal-regulated kinase by stretch-induced intravesical release of ATP

  Takeshi Sano; Takashi Kobayashi; Hiromitsu Negoro; Atsushi Sengiku; Takuya Hiratsuka; Yuji Kamioka; Louis S. Liou; Osamu Ogawa; Michiyuki Matsuda

  Physiological Reports, 01 Nov. 2016, Peer-reviewed

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• Cancer-specific mutations in p53 induce the translation of 160p53 promoting tumorigenesis

  Marco M. Candeias; Masatoshi Hagiwara; Michiyuki Matsuda

  EMBO REPORTS, Nov. 2016, Peer-reviewed

  
• Two New FRET Imaging Measures: Linearly Proportional to and Highly Contrasting the Fraction of Active Molecules

  Masataka Yamao; Kazuhiro Aoki; Naoto Yukinawa; Shin Ishii; Michiyuki Matsuda; Honda Naoki

  PLOS ONE, Oct. 2016, Peer-reviewed

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• Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice.

  Keiko Sakamoto; Yuji Fukushima; Koyu Ito; Michiyuki Matsuda; Shigekazu Nagata; Nagahiro Minato; Masakazu Hattori

  Journal of immunology (Baltimore, Md. : 1950), 15 Sep. 2016, Peer-reviewed

  
• In Vivo FRET Imaging of Tumor Endothelial Cells Highlights a Role of Low PKA Activity in Vascular Hyperpermeability

  Fumio Yamauchi; Yuji Kamioka; Tetsuya Yano; Michiyuki Matsuda

  CANCER RESEARCH, Sep. 2016, Peer-reviewed

  
• Identification of Aging-Associated Gene Expression Signatures That Precede Intestinal Tumorigenesis

  Yoshihisa Okuchi; Masamichi Imajo; Rei Mizuno; Yuji Kamioka; Hiroyuki Miyoshi; Makoto Mark Taketo; Satoshi Nagayama; Yoshiharu Sakai; Michiyuki Matsuda

  PLOS ONE, Sep. 2016, Peer-reviewed

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• Live imaging of transforming growth factor-beta activated kinase 1 activation in Lewis lung carcinoma 3LL cells implanted into syngeneic mice and treated with polyinosinic:polycytidylic acid

  Saori Takaoka; Yuji Kamioka; Kanako Takakura; Ai Baba; Hiroaki Shime; Tsukasa Seya; Michiyuki Matsuda

  CANCER SCIENCE, May 2016, Peer-reviewed

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• Visualization of signaling molecules during neutrophil recruitment in transgenic mice expressing FRET Biosensors

  Mizuno, R.; Kamioka, Y.; Sakai, Y.; Matsuda, M.

  Methods in Molecular Biology, 2016, Peer-reviewed

  
• Multiplexed Fluorescence Imaging of ERK and Akt Activities and Cell-cycle Progression

  Gembu Maryu; Michiyuki Matsuda; Kazuhiro Aoki

  CELL STRUCTURE AND FUNCTION, 2016, Peer-reviewed

  
• Distinct predictive performance of Rac1 and Cdc42 in cell migration

  Masataka Yamao; Honda Naoki; Katsuyuki Kunida; Kazuhiro Aoki; Michiyuki Matsuda; Shin Ishii

  SCIENTIFIC REPORTS, Dec. 2015, Peer-reviewed

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• mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells

  Naoki Komatsu; Yoshihisa Fujita; Michiyuki Matsuda; Kazuhiro Aoki

  Oncogene, Nov. 2015, Peer-reviewed

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• mTORC1 upregulation via ERK-dependent gene expression change confers intrinsic resistance to MEK inhibitors in oncogenic KRas-mutant cancer cells

  N. Komatsu; Y. Fujita; M. Matsuda; K. Aoki

  ONCOGENE, Nov. 2015, Peer-reviewed

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• Role of PKA signaling in D2 receptor-expressing neurons in the core of the nucleus accumbens in aversive learning

  Takashi Yamaguchi; Akihiro Goto; Ichiro Nakahara; Satoshi Yawata; Takatoshi Hikida; Michiyuki Matsuda; Kazuo Funabiki; Shigetada Nakanishi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 2015, Peer-reviewed

  
• Quantitative analysis of recombination between YFP and CFP genes of FRET biosensors introduced by lentiviral or retroviral gene transfer

  Akira T. Komatsubara; Michiyuki Matsuda; Kazuhiro Aoki

  SCIENTIFIC REPORTS, Aug. 2015, Peer-reviewed

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• Circuit-dependent striatal PKA and ERK signaling underlies rapid behavioral shift in mating reaction of male mice

  Akihiro Goto; Ichiro Nakahara; Takashi Yamaguchi; Yuji Kamioka; Kenta Sumiyama; Michiyuki Matsuda; Shigetada Nakanishi; Kazuo Funabiki

  Proceedings of the National Academy of Sciences of the United States of America, 26 May 2015, Peer-reviewed

  
• Circuit-dependent striatal PKA and ERK signaling underlies rapid behavioral shift in mating reaction of male mice

  Akihiro Goto; Ichiro Nakahara; Takashi Yamaguchi; Yuji Kamioka; Kenta Sumiyama; Michiyuki Matsuda; Shigetada Nakanishi; Kazuo Funabiki

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2015, Peer-reviewed

  
• Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin beta 1/FAK Signaling

  Eishu Hirata; Maria Romina Girotti; Amaya Viros; Steven Hooper; Bradley Spencer-Dene; Michiyuki Matsuda; James Larkin; Richard Marais; Erik Sahai

  CANCER CELL, Apr. 2015, Peer-reviewed

  
• Heterogeneity in ERK activity as visualized by in vivo FRET imaging of mammary tumor cells developed in MMTV-Neu mice

  Y. Kumagai; H. Naoki; E. Nakasyo; Y. Kamioka; E. Kiyokawa; M. Matsuda

  ONCOGENE, Feb. 2015, Peer-reviewed

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• Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin

  Toru Hiratsuka; Yoshihisa Fujita; Honda Naoki; Kazuhiro Aoki; Yuji Kamioka; Michiyuki Matsuda

  ELIFE, Feb. 2015, Peer-reviewed

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• Cdc42 Mediates Bmp-Induced Sprouting Angiogenesis through Fmnl3-Driven Assembly of Endothelial Filopodia in Zebrafish

  Yuki Wakayama; Shigetomo Fukuhara; Koji Ando; Michiyuki Matsuda; Naoki Mochizuki

  DEVELOPMENTAL CELL, Jan. 2015, Peer-reviewed

  
• In vivo imaging of intracellular signaling molecules: Come/Stop signals of neutrophils during acute inflammation

  Kamioka, Y.; Mizuno, R.; Matsuda, M.

  [Rinshō ketsueki] The Japanese journal of clinical hematology, 2015, Peer-reviewed

  
• PKA modulation of Rac in neuronal cells

  Akihiro Goto; Yuji Kamioka; Michiyuki Matsuda

  FRONTIERS IN CELLULAR NEUROSCIENCE, Oct. 2014, Peer-reviewed

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• Quantitative In Vivo Fluorescence Cross-Correlation Analyses Highlight the Importance of Competitive Effects in the Regulation of Protein-Protein Interactions

  Wakako Sadaie; Yoshie Harada; Michiyuki Matsuda; Kazuhiro Aoki

  MOLECULAR AND CELLULAR BIOLOGY, Sep. 2014, Peer-reviewed

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• Fluorescence resonance energy transfer based quantitative analysis of feedforward and feedback loops in epidermal growth factor receptor signaling and the sensitivity to molecular targeting drugs

  Yoshihisa Fujita; Naoki Komatsu; Michiyuki Matsuda; Kazuhiro Aoki

  FEBS JOURNAL, Jul. 2014, Peer-reviewed

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• In vivo imaging reveals PKA regulation of ERK activity during neutrophil recruitment to inflamed intestines

  Rei Mizuno; Yuji Kamioka; Kenji Kabashima; Masamichi Imajo; Kenta Sumiyama; Eiji Nakasho; Takeshi Ito; Yoko Hamazaki; Yoshihisa Okuchi; Yoshiharu Sakai; Etsuko Kiyokawa; Michiyuki Matsuda

  JOURNAL OF EXPERIMENTAL MEDICINE, Jun. 2014, Peer-reviewed

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• Maintenance of stereocilia and apical junctional complexes by Cdc42 in cochlear hair cells

  Takehiko Ueyama; Hirofumi Sakaguchi; Takashi Nakamura; Akihiro Goto; Shigefumi Morioka; Aya Shimizu; Kazuki Nakao; Yoshitaka Hishikawa; Yuzuru Ninoyu; Hidetoshi Kassai; Shiro Suetsugu; Takehiko Koji; Bernd Fritzsch; Shigenobu Yonemura; Yasuo Hisa; Michiyuki Matsuda; Atsu Aiba; Naoaki Saito

  JOURNAL OF CELL SCIENCE, May 2014, Peer-reviewed

  
• Fluctuation of Rac1 activity is associated with the phenotypic and transcriptional heterogeneity of glioma cells

  Hiroko Yukinaga; Clara Shionyu; Eishu Hirata; Kumiko Ui-Tei; Takeshi Nagashima; Shinji Kondo; Mariko Okada-Hatakeyama; Honda Naoki; Michiyuki Matsuda

  JOURNAL OF CELL SCIENCE, Apr. 2014, Peer-reviewed

  
• Development of a FRET Biosensor with High Specificity for Akt

  Haruko Miura; Michiyuki Matsuda; Kazuhiro Aoki

  CELL STRUCTURE AND FUNCTION, 2014, Peer-reviewed

  
• Cell Cycle-Dependent Rho GTPase Activity Dynamically Regulates Cancer Cell Motility and Invasion In Vivo

  Yoshinori Kagawa; Shinji Matsumoto; Yuji Kamioka; Koshi Mimori; Yoko Naito; Taeko Ishii; Daisuke Okuzaki; Naohiro Nishida; Sakae Maeda; Atsushi Naito; Junichi Kikuta; Keizo Nishikawa; Junichi Nishimura; Naotsugu Haraguchi; Ichiro Takemasa; Tsunekazu Mizushima; Masataka Ikeda; Hirofumi Yamamoto; Mitsugu Sekimoto; Hideshi Ishii; Yuichiro Doki; Michiyuki Matsuda; Akira Kikuchi; Masaki Mori; Masaru Ishii

  PLOS ONE, Dec. 2013, Peer-reviewed

  
• Stochastic ERK activation induced by noise and cell-to-cell propagation regulates cell density-dependent proliferation

  Kazuhiro Aoki; Yuka Kumagai; Atsuro Sakurai; Naoki Komatsu; Yoshihisa Fujita; Clara Shionyu; Michiyuki Matsuda

  Molecular Cell, 21 Nov. 2013, Peer-reviewed

  
• Development of a FRET biosensor with high specificity for Akt

  Haruko Miura; Michiyuki Matsuda; Kazuhiro Aoki

  Cell Structure and Function, 09 Nov. 2013, Peer-reviewed

  
• Fluorescence resonance energy transfer imaging of cell signaling from in vitro to in vivo: Basis of biosensor construction, live imaging, and image processing

  Kazuhiro Aoki; Yuji Kamioka; Michiyuki Matsuda

  Development Growth and Differentiation, May 2013, Peer-reviewed

  
• GDNF and endothelin 3 regulate migration of enteric neural crest-derived cells via protein kinase A and Rac1

  Akihiro Goto; Kenta Sumiyama; Yuji Kamioka; Eiji Nakasyo; Keisuke Ito; Mitsuhiro Iwasaki; Hideki Enomoto; Michiyuki Matsuda

  Journal of Neuroscience, 13 Mar. 2013, Peer-reviewed

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• A Quantitative Model of ERK MAP Kinase Phosphorylation in Crowded Media

  Kazuhiro Aoki; Koichi Takahashi; Kazunari Kaizu; Michiyuki Matsuda

  SCIENTIFIC REPORTS, Mar. 2013, Peer-reviewed

  
• Insufficient ability of Rac1b to perturb cystogenesis.

  Mori, Y.; Yagi, S.; Sakurai, A.; Matsuda, M.; Kiyokawa, E.

  Small GTPases, Jan. 2013, Peer-reviewed

  
• ２光子励起顕微鏡を用いたFRETイメージング

  上岡裕治; 松田道行

  生体の科学, 2013

  
• Chimaerin Suppresses Rac1 Activation at the Apical Membrane to Maintain the Cyst Structure

  Shunsuke Yagi; Michiyuki Matsuda; Etsuko Kiyokawa

  PLOS ONE, Dec. 2012, Peer-reviewed

  
• Activated Ras Protein Accelerates Cell Cycle Progression to Perturb Madin-Darby Canine Kidney Cystogenesis

  Atsuro Sakurai; Michiyuki Matsuda; Etsuko Kiyokawa

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2012, Peer-reviewed

  
• FRETプローブを発現するトランスジェニックマウスを用いたTPAによるERK活性変化のライブイメージング(Chronological imaging of TPA-induced ERK activation in TG mice expressing a FRET biosensor)

  平塚 徹; 野中 太一郎; 木下 和生; 松田 道行

  日本癌学会総会記事, Aug. 2012

  
• FRET imaging and statistical signal processing reveal positive and negative feedback loops regulating the morphology of randomly migrating HT-1080 cells

  Katsuyuki Kunida; Michiyuki Matsuda; Kazuhiro Aoki

  JOURNAL OF CELL SCIENCE, May 2012, Peer-reviewed

  
• Syndecan 4 Regulates FGFR1 Signaling in Endothelial Cells by Directing Macropinocytosis

  Arye Elfenbein; Anthony Lanahan; Theresa X. Zhou; Alisa Yamasaki; Eugene Tkachenko; Michiyuki Matsuda; Michael Simons

  SCIENCE SIGNALING, May 2012, Peer-reviewed

  
• Stable expression of FRET biosensors: A new light in cancer research

  Kazuhiro Aoki; Naoki Komatsu; Eishu Hirata; Yuji Kamioka; Michiyuki Matsuda

  CANCER SCIENCE, Apr. 2012, Peer-reviewed

  
• Suppression of Rac1 activity at the apical membrane of MDCK cells is essential for cyst structure maintenance

  Shunsuke Yagi; Michiyuki Matsuda; Etsuko Kiyokawa

  EMBO REPORTS, Mar. 2012, Peer-reviewed

  
• In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion

  Eishu Hirata; Hiroko Yukinaga; Yuji Kamioka; Yoshiki Arakawa; Susumu Miyamoto; Takaharu Okada; Erik Sahai; Michiyuki Matsuda

  JOURNAL OF CELL SCIENCE, Feb. 2012, Peer-reviewed

  
• Live imaging of protein kinase activities in transgenic mice expressing FRET biosensors

  Yuji Kamioka; Kenta Sumiyama; Rei Mizuno; Yoshiharu Sakai; Eishu Hirata; Etsuko Kiyokawa; Michiyuki Matsuda

  Cell Structure and Function, 2012, Peer-reviewed

  
• Development of an optimized backbone of FRET biosensors for kinases and GTPases

  Naoki Komatsu; Kazuhiro Aoki; Masashi Yamada; Hiroko Yukinaga; Yoshihisa Fujita; Yuji Kamioka; Michiyuki Matsuda

  MOLECULAR BIOLOGY OF THE CELL, Dec. 2011, Peer-reviewed

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• A genetically encoded Forster resonance energy transfer biosensor for two-photon excitation microscopy

  Yuka Kumagai; Yuji Kamioka; Shunsuke Yagi; Michiyuki Matsuda; Etsuko Kiyokawa

  ANALYTICAL BIOCHEMISTRY, Jun. 2011, Peer-reviewed

  
• SH3BP1, an Exocyst-Associated RhoGAP, Inactivates Rac1 at the Front to Drive Cell Motility

  Maria Carla Parrini; Amel Sadou-Dubourgnoux; Kazuhiro Aoki; Katsuyuki Kunida; Marco Biondini; Anastassia Hatzoglou; Patrick Poullet; Etienne Formstecher; Charles Yeaman; Michiyuki Matsuda; Carine Rosse; Jacques Camonis

  MOLECULAR CELL, Jun. 2011, Peer-reviewed

  
• Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP-treated PC12D cells

  Akihiro Goto; Mikio Hoshino; Michiyuki Matsuda; Takeshi Nakamura

  MOLECULAR BIOLOGY OF THE CELL, May 2011, Peer-reviewed

  
• Spatiotemporal Regulation of Small GTPases as Revealed by Probes Based on the Principle of Forster Resonance Energy Transfer (FRET): Implications for Signaling and Pharmacology

  Etsuko Kiyokawa; Kazuhiro Aoki; Takeshi Nakamura; Michiyuki Matsuda

  ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 51, 2011, 2011, Peer-reviewed

  
• 癌と生体イメージング 癌のFRET ライブイメージング FRET live imaging of cancer

  清川悦子; 上岡裕治; 松田道行

  Surgery Frontier, 2011

  
• Heterogeneity of Phosphatidic Acid Levels and Distribution at the Plasma Membrane in Living Cells as Visualized by a Forster Resonance Energy Transfer (FRET) Biosensor

  Teruko Nishioka; Michael A. Frohman; Michiyuki Matsuda; Etsuko Kiyokawa

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2010, Peer-reviewed

  
• Revolving movement of a dynamic cluster of actin filaments during mitosis

  Masaru Mitsushima; Kazuhiro Aoki; Miki Ebisuya; Shigeru Matsumura; Takuya Yamamoto; Michiyuki Matsuda; Fumiko Toyoshima; Eisuke Nishida

  JOURNAL OF CELL BIOLOGY, Nov. 2010, Peer-reviewed

  
• Real-time Fluorescent Resonance Energy Transfer Analysis to Monitor Drug Resistance in Chronic Myelogenous Leukemia

  Ahmet Tunceroglu; Michiyuki Matsuda; Raymond B. Birge

  MOLECULAR CANCER THERAPEUTICS, Nov. 2010, Peer-reviewed

  
• TWO MODES OF GLIOBLASTOMA INVASION: ANALYSIS WITH TWO-PHOTON EXCITATION MICROSCOPY AND FRET IMAGING

  Michiyuki Matsuda; Eishu Hirata; Yoshiki Arakawa; Susumu Miyamoto

  ANNALS OF ONCOLOGY, Nov. 2010, Peer-reviewed

  
• Multiple Decisive Phosphorylation Sites for the Negative Feedback Regulation of SOS1 via ERK

  Yuji Kamioka; Shuhei Yasuda; Yoshihisa Fujita; Kazuhiro Aoki; Michiyuki Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2010, Peer-reviewed

  
• Palmitoylated Ras proteins traffic through recycling endosomes to the plasma membrane during exocytosis

  Ryo Misaki; Miki Morimatsu; Takefumi Uemura; Satoshi Waguri; Eiji Miyoshi; Naoyuki Taniguchi; Michiyuki Matsuda; Tomohiko Taguchi

  JOURNAL OF CELL BIOLOGY, Oct. 2010, Peer-reviewed

  
• Ras and Calcium Signaling Pathways Converge at Raf1 via the Shoc2 Scaffold Protein

  Sayaka Yoshiki; Rie Matsunaga-Udagawa; Kazuhiro Aoki; Yuji Kamioka; Etsuko Kiyokawa; Michiyuki Matsuda

  MOLECULAR BIOLOGY OF THE CELL, Mar. 2010, Peer-reviewed

  
• The Scaffold Protein Shoc2/SUR-8 Accelerates the Interaction of Ras and Raf

  Rie Matsunaga-Udagawa; Yoshihisa Fujita; Sayaka Yoshiki; Kenta Terai; Yuji Kamioka; Etsuko Kiyokawa; Katsuyuki Yugi; Kazuhiro Aoki; Michiyuki Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2010, Peer-reviewed

  
• Dissecting Activation of the PAK1 Kinase at Protrusions in Living Cells

  Maria Carla Parrini; Jacques Camonis; Michiyuki Matsuda; Jean de Gunzburg

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2009, Peer-reviewed

  
• Endogenous tenascin-C enhances glioblastoma invasion with reactive change of surrounding brain tissue

  Eishu Hirata; Yoshiki Arakawa; Mitsuaki Shirahata; Makoto Yamaguchi; Yo Kishi; Takashi Okada; Jun A. Takahashi; Michiyuki Matsuda; Nobuo Hashimoto

  CANCER SCIENCE, Aug. 2009, Peer-reviewed

  
• Suppression of RhoG activity is mediated by a syndecan 4-synectin-RhoGDI1 complex and is reversed by PKC alpha in a Rac1 activation pathway

  Arye Elfenbein; John M. Rhodes; Julia Meller; Martin A. Schwartz; Michiyuki Matsuda; Michael Simons

  JOURNAL OF CELL BIOLOGY, Jul. 2009, Peer-reviewed

  
• Regulation of focal adhesion and cell migration by ANKRD28-DOCK180 interaction

  Etsuko Kiyokawa; Michiyuki Matsuda

  CELL ADHESION & MIGRATION, Jul. 2009, Peer-reviewed

  
• [Activity change of small GTPases Rac1 and Rab5 during phagocytosis].

  Takeshi Nakamura; Masahiro Kitano; Michio Nakaya; Shigekazu Nagata; Michiyuki Matsuda

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Jun. 2009, Peer-reviewed

  
• A clathrin-dependent pathway leads to KRas signaling on late endosomes en route to lysosomes

  Albert Lu; Francesc Tebar; Blanca Alvarez-Moya; Cristina Lopez-Alcala; Maria Calvo; Carlos Enrich; Neus Agell; Takeshi Nakamura; Michiyuki Matsuda; Oriol Bachs

  JOURNAL OF CELL BIOLOGY, Mar. 2009, Peer-reviewed

  
• Human Mena Associates with Rac1 Small GTPase in Glioblastoma Cell Lines

  Morihiro Higashi; Chieko Ishikawa; Jianyong Yu; Akihiro Toyoda; Hidetada Kawana; Kazuo Kurokawa; Michiyuki Matsuda; Motoo Kitagawa; Kenichi Harigaya

  PLOS ONE, Mar. 2009, Peer-reviewed

  
• Ankyrin repeat domain 28 (ANKRD28), a novel binding partner of DOCK180, promotes cell migration by regulating focal adhesion formation

  Mitsuhiro Tachibana; Etsuko Kiyokawa; Shigeo Hara; Shun-ichiro Iemura; Tohru Natsume; Toshiaki Manabe; Michiyuki Matsuda

  EXPERIMENTAL CELL RESEARCH, Mar. 2009, Peer-reviewed

  
• On the Synchrony of Morphological and Molecular Signaling Events in Cell Migration

  Justin Dauwels; Yuki Tsukada; Yuichi Sakumura; Shin Ishii; Kazuhiro Aoki; Takeshi Nakamura; Michiyuki Matsuda; Francois Vialatte; Andrzej Cichocki

  ADVANCES IN NEURO-INFORMATION PROCESSING, PT I, 2009, Peer-reviewed

  
• In vivo imaging of signal transduction cascades with probes based on Förster Resonance Energy Transfer (FRET)

  Takeshi Nakamura; Michiyuki Matsuda

  Current Protocols in Cell Biology, 2009, Peer-reviewed

  
• Visualization of small GTPase activity with fluorescence resonance energy transfer-based biosensors

  Kazuhiro Aoki; Michiyuki Matsuda

  NATURE PROTOCOLS, 2009, Peer-reviewed

  
• Quantification of Local Morphodynamics and Local GTPase Activity by Edge Evolution Tracking

  Yuki Tsukada; Kazuhiro Aoki; Takeshi Nakamura; Yuichi Sakumura; Michiyuki Matsuda; Shin Ishii

  PLOS COMPUTATIONAL BIOLOGY, Nov. 2008, Peer-reviewed

  
• Rapid Turnover Rate of Phosphoinositides at the Front of Migrating MDCK Cells

  Teruko Nishioka; Kazuhiro Aoki; Kazuhiro Hikake; Hisayoshi Yoshizaki; Etsuko Kiyokawa; Michiyuki Matsuda

  MOLECULAR BIOLOGY OF THE CELL, Oct. 2008, Peer-reviewed

  
• The DHR1 domain of DOCK180 binds to SNX5 and regulates cation-independent mannose 6-phosphate receptor transport

  Shigeo Hara; Etsuko Kiyokawa; Shun-ichiro Iemura; Tohru Natsume; Thomas Wassmer; Peter J. Cullen; Hiroshi Hiai; Michiyuki Matsuda

  MOLECULAR BIOLOGY OF THE CELL, Sep. 2008, Peer-reviewed

  
• FRET imaging and in silico simulation: analysis of the signaling network of nerve growth factor-induced neuritogenesis

  Takeshi Nakamura; Kazuhiro Aoki; Michiyuki Matsuda

  BRAIN CELL BIOLOGY, Aug. 2008, Peer-reviewed

  
• Phosphorylation and activation of the Rac1 and Cdc42 GEF Asef in A431 cells stimulated by EGF

  Reina E. Itoh; Etsuko Kiyokawa; Kazuhiro Aoki; Teruko Nishioka; Tetsu Akiyama; Michiyuki Matsuda

  JOURNAL OF CELL SCIENCE, Aug. 2008, Peer-reviewed

  
• Visualization of growth signal transduction cascades in living cells with genetically encoded probes based on Forster resonance energy transfer

  Kazuhiro Aoki; Etsuko Kiyokawa; Takeshi Nakamura; Michiyuki Matsuda

  PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Jun. 2008, Peer-reviewed

  
• Imaging of Rab5 activity identifies essential regulators for phagosome maturation

  Masahiro Kitano; Michio Nakaya; Takeshi Nakamura; Shigekazu Nagata; Michiyuki Matsuda

  NATURE, May 2008, Peer-reviewed

  
• Mutation of Dock5, a member of the guanine exchange factor Dock180 superfamily, in the rupture of lens cataract mouse

  Natsue Omi; Etsuko Kiyokawa; Michiyuki Matsuda; Kazuo Kinoshita; Shuichi Yamada; Kazumi Yamada; Yoshibumi Matsushima; Yun Wang; Jun Kawai; Masanori Suzuki; Yoshihide Hayashizaki; Hiroshi Hiai

  EXPERIMENTAL EYE RESEARCH, May 2008, Peer-reviewed

  
• Rap1-PDZ-GEF1 interacts with a neurotrophin receptor at late endosomes, leading to sustained activation of Rap1 and ERK and neurite outgrowth

  Shu Hisata; Toshiaki Sakisaka; Takeshi Baba; Tomohiro Yamada; Kazubiro Aoki; Mlchiyuki Matsuda; Yoshimi Takai

  JOURNAL OF CELL BIOLOGY, Aug. 2007, Peer-reviewed

  
• アンキリンリピートドメイン28(ANKRD28)[新規DOCK180結合因子]は、細胞遊走を制御する(Ankyrin repeat domain 28 (ANKRD28), a novel binding partner of DOCK180, regulates cell migration)

  橘 充弘; 清川 悦子; 原 重雄; 真鍋 俊明; 松田 道行

  日本癌学会総会記事, Aug. 2007

  
• DOCK180はSNX5相互作用を介してカチオン非依存性マンノース-6-リン酸受容体輸送を制御する(DOCK180 regulates cation-independent mannose-6-phosphate receptor transport through SNX5 interaction)

  原 重雄; 清川 悦子; 橘 充弘; 松田 道行

  日本癌学会総会記事, Aug. 2007

  
• An essential role for the SHIP2-dependent negative feedback loop in neuritogenesis of nerve growth factor-stimulated PC12 cells

  Kazuhiro Aoki; Takeshi Nakamura; Takanari Inoue; Tobias Meyer; Michiyuki Matsuda

  JOURNAL OF CELL BIOLOGY, Jun. 2007, Peer-reviewed

  
• R-ras regulates exocytosis by Rgl2/Rlf-mediated activation of RalA on endosomes

  Akiyuki Takaya; Takahiro Kamio; Michitaka Masuda; Naoki Mochizuki; Hirofumi Sawa; Mami Sato; Kazuo Nagashima; Akiko Mizutani; Akira Matsuno; Etsuko Kiyokawa; Michiyuki Matsuda

  MOLECULAR BIOLOGY OF THE CELL, May 2007, Peer-reviewed

  
• Differential ras activation between caveolae/raft and non-raft Microdomains

  Takashi Fukano; Asako Sawano; Yusuke Ohba; Michiyuki Matsuda; Atsushi Miyawaki

  CELL STRUCTURE AND FUNCTION, 2007, Peer-reviewed

  
• Akt-PDK1 complex mediates epidermal growth factor-induced membrane protrusion through Ral activation

  Hisayoshi Yoshizaki; Naoki Mochizuki; Yukiko Gotoh; Michiyuki Matsuda

  MOLECULAR BIOLOGY OF THE CELL, Jan. 2007, Peer-reviewed

  
• Purification and characterization of Heteroscorpine-1 (HS-1) toxin from Heterometrus laoticus scorpion venom

  Nunthawun Uawonggul; Sompong Thammasirirak; Arunrat Chaveerach; Tarinee Arkaravichien; Wandee Bunyatratchata; Wipaporn Ruangjirachuporn; Pornpimol Jearranaiprepame; Takeshi Nakamura; Michiyuki Matsuda; Michimoto Kobayashi; Seisuke Hattori; Sakda Daduang

  TOXICON, Jan. 2007, Peer-reviewed

  
• Regulation of RaIA GTPase by phosphatidylinositol 3-kinase as visualized by FRET probes

  H. Yoshizaki; K. Aoki; T. Nakamura; M. Matsuda

  BIOCHEMICAL SOCIETY TRANSACTIONS, Nov. 2006, Peer-reviewed

  
• The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-Src

  Norikazu Yamana; Yoshiki Arakawa; Tomohiro Nishino; Kazuo Kurokawa; Masahiro Tanji; Reina E. Itoh; James Monypenny; Toshimasa Ishizaki; Haruhiko Bito; Kazuhiko Nozaki; Nobuo Hashimoto; Michiyuki Matsuda; Shuh Narumiya

  MOLECULAR AND CELLULAR BIOLOGY, Sep. 2006, Peer-reviewed

  
• GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion

  Kazuho Kawase; Takeshi Nakamura; Akiyuki Takaya; Kazuhiro Aoki; Kazuhiko Namikawa; Hiroshi Kiyama; Shuichiro Inagaki; Hiroshi Takemoto; Alan R. Saltiel; Michiyuki Matsuda

  DEVELOPMENTAL CELL, Sep. 2006, Peer-reviewed

  
• The amino-terminal B-Raf-specific region mediates calcium-dependent homo- and hetero-dimerization of Raf

  Kenta Terai; Michiyuki Matsuda

  EMBO JOURNAL, Aug. 2006, Peer-reviewed

  
• Dynamics of the Ras/ERK MAPK cascade as monitored by fluorescent probes

  A Fujioka; K Terai; RE Itoh; K Aoki; T Nakamura; S Kuroda; E Nishida; M Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2006, Peer-reviewed

  
• Activity of Rho-family G proteins as visualized with FRET-based probes

  H. Yoshizak; N. Mochizuki; M. Matsuda

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme., 2006, Peer-reviewed

  
• Fluorescence (Forster) resonance energy transfer imaging of oncogene activity in living cells

  E Kiyokawa; S Hara; T Nakamura; M Matsuda

  CANCER SCIENCE, Jan. 2006, Peer-reviewed

  
• Analysis of the spatiotemporal activation of rho GTPases using Raichu probes

  T Nakamura; K Kurokawa; E Kiyokawa; M Matsuda

  METHODS IN ENZYMOLOGY, VOL 406, REGULATORS AND EFFECTORS OF SMALL GTPASES: RHO FAMILY, 2006, Peer-reviewed

  
• Monitoring spatio-temporal regulation of Ras and Rho GTPases with GFP-based FRET probes

  T Nakamura; K Aoki; M Matsuda

  METHODS, Oct. 2005, Peer-reviewed

  
• FRET imaging in nerve growth cones reveals a high level of RhoA activity within the peripheral domain

  T Nakamura; K Aoki; M Matsuda

  MOLECULAR BRAIN RESEARCH, Oct. 2005, Peer-reviewed

  
• Localized RhoA activation as a requirement for the induction of membrane ruffling

  K Kurokawa; M Matsuda

  MOLECULAR BIOLOGY OF THE CELL, Sep. 2005, Peer-reviewed

  
• Spatiotemporal regulation of the Pak1 kinase

  MC Parrini; M Matsuda; J de Gunzburg

  BIOCHEMICAL SOCIETY TRANSACTIONS, Aug. 2005, Peer-reviewed

  
• Mechanism and role of localized activation of Rho-family GTPases in growth factor-stimulated fibroblasts and neuronal cells

  K Kurokawa; T Nakamura; K Aoki; M Matsuda

  BIOCHEMICAL SOCIETY TRANSACTIONS, Aug. 2005, Peer-reviewed

  
• A FRET-based probe for epidermal growth factor receptor bound non-covalently to a pair of synthetic amphipathic helixes

  RE Itoh; K Kurokawa; A Fujioka; A Sharma; BJ Mayer; M Matsuda

  EXPERIMENTAL CELL RESEARCH, Jul. 2005, Peer-reviewed

  
• Local phosphatidylinositol 3,4,5-trisphosphate accumulation recruits Vav2 and Vav3 to activate Rac1/Cdc42 and initiate neurite outgrowth in nerve growth factor-stimulated PC12 cells

  K Aoki; T Nakamura; K Fujikawa; M Matsuda

  MOLECULAR BIOLOGY OF THE CELL, May 2005, Peer-reviewed

  
• Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-alpha induction

  S Uematsu; S Sato; M Yamamoto; T Hirotani; H Kato; F Takeshita; M Matsuda; C Coban; KJ Ishii; T Kawai; O Takeuchi; S Akira

  JOURNAL OF EXPERIMENTAL MEDICINE, Mar. 2005, Peer-reviewed

  
• Ras binding opens c-Raf to expose the docking site for mitogen-activated protein kinase kinase

  K Terai; M Matsuda

  EMBO REPORTS, Mar. 2005, Peer-reviewed

  
• Involvement of the c-Src-Crk-C3G-Rap1 signaling in the nectin-induced activation of Cdc42 and formation of adherens junctions

  T Fukuyama; H Ogita; T Kawakatsu; T Fukuhara; T Yamada; T Sato; K Shimizu; T Nakamura; M Matsuda; Y Takai

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2005, Peer-reviewed

  
• Cell type-specific regulation of RhoA activity during cytokinesis

  H Yoshizaki; Y Ohba; MC Parrini; NG Dulyaninova; AR Bresnick; N Mochizuki; M Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2004, Peer-reviewed

  
• Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

  T Kawai; S Sato; KJ Ishii; C Coban; H Hemmi; M Yamamoto; K Terai; M Matsuda; J Inoue; S Uematsu; O Takeuchi; S Akira

  NATURE IMMUNOLOGY, Oct. 2004, Peer-reviewed

  
• STAT3 noncell-autonomously controls planar cell polarity during zebrafish convergence and extension

  C Miyagi; S Yamashita; Y Ohba; H Yoshizaki; M Matsuda; T Hirano

  JOURNAL OF CELL BIOLOGY, Sep. 2004, Peer-reviewed

  
• A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis

  Y Kamioka; S Fukuhara; H Sawa; J Nagashima; M Masuda; M Matsuda; N Mochizuki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2004, Peer-reviewed

  
• Roles played by a subset of integrin signaling molecules in cadherin-based cell-cell adhesion

  H Yano; Y Mazaki; K Kurokawa; SK Hanks; M Matsuda; H Sabe

  JOURNAL OF CELL BIOLOGY, Jul. 2004, Peer-reviewed

  
• RalA activation at nascent lamellipodia of epidermal growth factor-stimulated Cos7 cells and migrating Madin-Darby canine kidney Cells

  A Takaya; Y Ohba; K Kurokawa; M Matsuda

  MOLECULAR BIOLOGY OF THE CELL, Jun. 2004, Peer-reviewed

  
• Coactivation of Rad1 and Cdc42 at lamellipodia and membrane ruffles induced by epidermal growth factor

  K Kurokawa; RE Itoh; H Yoshizaki; Y Ohba; T Nakamura; M Matsuda

  MOLECULAR BIOLOGY OF THE CELL, Mar. 2004, Peer-reviewed

  
• A novel role of nectins in inhibition of the e-cadherin-induced activation of Rac and formation of cell-cell adherens junctions

  T Hoshino; K Shimizu; T Honda; T Kawakatsu; T Fukuyama; T Nakamura; M Matsuda; Y Takai

  MOLECULAR BIOLOGY OF THE CELL, Mar. 2004, Peer-reviewed

  
• Spatio-temporal regulation of Rac1 and Cdc42 activity during nerve growth factor-induced neurite outgrowth in PC12 cells

  K Aoki; T Nakamura; M Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2004, Peer-reviewed

  
• Visualization of signal transduction of Ras

  Y Ohba; M Matsuda

  SEIKAGAKU, Jan. 2004, Peer-reviewed

  
• Visualizing the signal transduction pathways in living cells with GFP-based FRET probes

  K Kurokawa; A Takaya; K Terai; A Fujioka; M Matsuda

  ACTA HISTOCHEMICA ET CYTOCHEMICA, 2004, Peer-reviewed

  
• Activity of Rho-family GTPases during cell division as visualized with FRET-based probes

  H Yoshizaki; Y Ohba; K Kurokawa; RE Itoh; T Nakamura; N Mochizuki; K Nagashima; M Matsuda

  JOURNAL OF CELL BIOLOGY, Jul. 2003, Peer-reviewed

  
• Cdc42 and Rac small G proteins activated by trans- interactions of nectins are involved in activation of c-Jun N-terminal kinase, but not in association of nectins and cadherin to form adherens junctions, in fibroblasts

  T Honda; K Shimizu; T Kawakatsu; A Fukuhara; K Irie; T Nakamura; M Matsuda; Y Takai

  GENES TO CELLS, May 2003, Peer-reviewed

  
• Mechanism of the spatio-temporal regulation of Ras and Rap1

  Y Ohba; K Kurokawa; M Matsuda

  EMBO JOURNAL, Feb. 2003, Peer-reviewed

  
• Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation

  A Sakakibara; Y Ohba; K Kurokawa; M Matsuda; S Hattori

  JOURNAL OF CELL SCIENCE, Dec. 2002, Peer-reviewed

  
• Adaptor protein Crk is required for ephrin-B1-induced membrane ruffling and focal complex assembly of human aortic endothelial cells

  KI Nagashima; A Endo; H Ogita; A Kawana; A Yamagishi; A Kitabatake; M Matsuda; N Mochizuki

  MOLECULAR BIOLOGY OF THE CELL, Dec. 2002, Peer-reviewed

  
• Activation of Rac and Cdc42 video imaged by fluorescent resonance energy transfer-based single-molecule probes in the membrane of living cells

  RE Itoh; K Kurokawa; Y Ohba; H Yoshizaki; N Mochizuki; M Matsuda

  MOLECULAR AND CELLULAR BIOLOGY, Sep. 2002, Peer-reviewed

  
• Lateral propagation of EGF signaling after local stimulation is dependent on receptor density

  A Sawano; S Takayama; M Matsuda; A Miyawaki

  DEVELOPMENTAL CELL, Aug. 2002, Peer-reviewed

  
• A mammalian two-hybrid screening system for inhibitors of interaction between HIV Nef and the cellular tyrosine kinase Hck

  Y Murakami; H Fukazawa; T Kobatake; S Yamagoe; Y Takebe; M Tobiume; M Matsuda; Y Uehara

  ANTIVIRAL RESEARCH, Jul. 2002, Peer-reviewed

  
• Sphingosine 1-phosphate induces membrane ruffling and increases motility of human umbilical vein endothelial cells via vascular endothelial growth factor receptor and CrkII

  A Endo; KI Nagashima; H Kurose; S Mochizuki; M Matsuda; N Mochizuki

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2002, Peer-reviewed

  
• Inefficient enhancement of viral infectivity and CD4 downregulation by human immunodeficiency virus type 1 nef from Japanese long-term nonprogressors

  M Tobiume; M Takahoko; T Yamada; M Tatsumi; A Iwamoto; M Matsuda

  JOURNAL OF VIROLOGY, Jun. 2002, Peer-reviewed

  
• Establishment of a MAGI-derived indicator cell line that detects the Nef enhancement of HIV-1 infectivity with high sensitivity

  M Tobium; M Takahoko; M Tatsumi; M Matsuda

  JOURNAL OF VIROLOGICAL METHODS, Sep. 2001, Peer-reviewed

  
• A pair of fluorescent resonance energy transfer-based probes for tyrosine phosphorylation of the CrkII adaptor protein in vivo

  K Kurokawa; N Mochizuki; Y Ohba; H Mizuno; A Miyawaki; M Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2001, Peer-reviewed

  
• Requirement for C3G-dependent Rap1 activation for cell adhesion and embryogenesis

  Y Ohba; K Ikuta; A Ogura; J Matsuda; N Mochizuki; K Nagashima; K Kurokawa; BJ Mayer; K Maki; J Miyazaki; M Matsuda

  EMBO JOURNAL, Jul. 2001, Peer-reviewed

  
• Infectious DNA clone of HIV type 1 A/G recombinant (CRF02_AG) replicable in peripheral blood mononuclear cells

  M Takahoko; M Tobiume; K Ishikawa; W Ampofo; N Yamamoto; M Matsuda; M Tatsumi

  AIDS RESEARCH AND HUMAN RETROVIRUSES, Jul. 2001, Peer-reviewed

  
• Spatio-temporal images of growth-factor-induced activation of Ras and Rap1

  N Mochizuki; S Yamashita; K Kurokawa; Y Ohba; T Nagai; A Miyawaki; M Matsuda

  NATURE, Jun. 2001, Peer-reviewed

  
• Membrane recruitment of DOCK180 by binding to Ptdlns(3,4,5)P-3

  S Kobayashi; T Shirai; E Kiyokawa; N Mochizuki; M Matsuda; Y Fukui

  BIOCHEMICAL JOURNAL, Feb. 2001, Peer-reviewed

  
• Requirement of Nef for HIV-1 infectivity is biased by the expression levels of Env in the virus-producing cells and CD4 in the target cells

  M Tobiume; K Tokunaga; E Kiyokawa; M Takahoko; N Mochizuki; M Tatsumi; M Matsuda

  ARCHIVES OF VIROLOGY, 2001, Peer-reviewed

  
• CalDAG-GEFIII activation of Ras, R-Ras, and Rap1

  S Yamashita; N Mochizuki; Y Ohba; M Tobiume; Y Okada; H Sawa; K Nagashima; M Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2000, Peer-reviewed

  
• Rap2 as a slowly responding molecular switch in the Rap1 signaling cascade

  Y Ohba; N Mochizuki; K Matsuo; S Yamashita; M Nakaya; Y Hashimoto; M Hamaguchi; T Kurata; K Nagashima; M Matsuda

  MOLECULAR AND CELLULAR BIOLOGY, Aug. 2000, Peer-reviewed

  
• Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3

  Y Ohba; N Mochizuki; S Yamashita; AM Chan; JW Schrader; S Hattori; K Nagashima; M Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2000, Peer-reviewed

  
• Crk activation of JNK via C3G and R-Ras

  N Mochizuki; Y Ohba; S Kobayashi; N Otsuka; AM Graybiel; S Tanaka; M Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2000, Peer-reviewed

  
• Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation

  T Matsumoto; K Yokote; A Take; M Takemoto; S Asaumi; Y Hashimoto; M Matsuda; Y Saito; S Mori

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2000, Peer-reviewed

  
• Non-adherent cell-specific expression of DOCK2, a member of the human CDM-family proteins

  H Nishihara; S Kobayashi; Y Hashimoto; F Ohba; N Mochizuki; T Kurata; K Nagashima; M Matsuda

  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, Nov. 1999, Peer-reviewed

  
• Epidermal growth factor-dependent dissociation of CrkII proto-oncogene product from the epidermal growth factor receptor in human glioma cells

  H Katayama; Y Hashimoto; E Kiyokawa; M Nakaya; A Sakamoto; R Machinami; T Kurata; N Mochizuki; M Matsuda

  JAPANESE JOURNAL OF CANCER RESEARCH, Oct. 1999, Peer-reviewed

  
• An infectious DNA clone of HIV type 1 subtype C

  N Mochizuki; N Otsuka; K Matsuo; T Shiino; A Kojima; T Kurata; K Sakai; N Yamamoto; S Isomura; TN Dhole; Y Takebe; M Matsuda; M Tatsumi

  AIDS RESEARCH AND HUMAN RETROVIRUSES, Sep. 1999, Peer-reviewed

  
• Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i)

  N Mochizuki; Y Ohba; E Kiyokawa; T Kurata; T Murakami; T Ozaki; A Kitabatake; K Nagashima; M Matsuda

  NATURE, Aug. 1999, Peer-reviewed

  
• Activation of C3G guanine nucleotide exchange factor for Rap1 by phosphorylation of tyrosine 504

  T Ichiba; Y Hashimoto; M Nakaya; Y Kuraishi; S Tanaka; T Kurata; N Mochizuki; M Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 1999, Peer-reviewed

  
• The cellular kinase binding motifs (PxxP and RR) in human immunodeficiency virus type 1 Nef protein are dispensable for producer-cell-dependent enhancement of viral entry

  K Tokunaga; K Ikuta; A Adachi; M Matsuda; T Kurata; A Kojima

  VIROLOGY, May 1999, Peer-reviewed

  
• A family of cAMP-binding proteins that directly activate Rap1

  H Kawasaki; GM Springett; N Mochizuki; S Toki; M Nakaya; M Matsuda; DE Housman; AM Graybiel

  SCIENCE, Dec. 1998, Peer-reviewed

  
• Activation of Rac1 by a Crk SH3-binding protein, DOCK180

  E Kiyokawa; Y Hashimoto; S Kobayashi; H Sugimura; T Kurata; M Matsuda

  GENES & DEVELOPMENT, Nov. 1998, Peer-reviewed

  
• Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex

  E Kiyokawa; Y Hashimoto; T Kurata; H Sugimura; M Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 1998, Peer-reviewed

  
• Inhibition of human immunodeficiency virus type 1 virion entry by dominant-negative Hck

  K Tokunaga; E Kiyokawa; M Nakaya; N Otsuka; A Kojima; T Kurata; M Matsuda

  JOURNAL OF VIROLOGY, Jul. 1998, Peer-reviewed

  
• Phosphorylation of CrkII adaptor protein at tyrosine 221 by epidermal growth factor receptor

  Y Hashimoto; H Katayama; E Kiyokawa; S Ota; T Kurata; N Gotoh; N Otsuka; M Shibata; M Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 1998, Peer-reviewed

  
• Insulin regulates the dynamic balance between Ras and Rap1 signaling by coordinating the assembly states of the Grb2-SOS and CrkII-C3G complexes

  S Okada; M Matsuda; M Anafi; T Pawson; JE Pessin

  EMBO JOURNAL, May 1998, Peer-reviewed

  
• Constitutive association of EGF receptor with the CrkII-23 mutant that inhibits transformation of NRK cells by EGF and TGF-beta

  S Ota; S Kizaka-Kondoh; Y Hashimoto; H Nishihara; K Nagashima; T Kurata; H Okayama; M Matsuda

  CELLULAR SIGNALLING, Apr. 1998, Peer-reviewed

  
• Enhancement of guanine-nucleotide exchange activity of C3G for Rap1 by the expression of Crk, CrkL, and Grb2

  T Ichiba; Y Kuraishi; O Sakai; S Nagata; J Groffen; T Kurata; S Hattori; M Matsuda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 1997, Peer-reviewed

  
• Activation of R-Ras by Ras-guanine nucleotide-releasing factor

  T Gotoh; Y Niino; M Tokuda; O Hatase; S Nakamura; M Matsuda; S Hattori

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 1997, Peer-reviewed

  
• Role of Crk oncogene product in physiologic signaling

  E Kiyokawa; N Mochizuki; T Kurata; M Matsuda

  CRITICAL REVIEWS IN ONCOGENESIS, 1997, Peer-reviewed

  
• B cell antigen receptor signaling induces the formation of complexes containing the Crk adapter proteins

  RJ Ingham; DL Krebs; SM Barbazuk; CW Turck; H Hirai; M Matsuda; MR Gold

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1996, Peer-reviewed

  
• Emerging components of the Crk oncogene product: The first identified adaptor protein

  M Matsuda; T Kurata

  CELLULAR SIGNALLING, Aug. 1996, Peer-reviewed

  
• Chromosomal mapping of the gene encoding DOCK180, a major Crk-binding protein, to 10q26.13-q26.3 by fluorescence in situ hybridization

  S Takai; H Hasegawa; E Kiyokawa; K Yamada; T Kurata; M Matsuda

  GENOMICS, Jul. 1996, Peer-reviewed

  
• Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins

  M Matsuda; S Ota; R Tanimura; H Nakamura; K Matuoka; T Takenawa; K Nagashima; T Kurata

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 1996, Peer-reviewed

  
• DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane

  H Hasegawa; E Kiyokawa; S Tanaka; K Nagashima; N Gotoh; M Shibuya; T Kurata; M Matsuda

  MOLECULAR AND CELLULAR BIOLOGY, Apr. 1996, Peer-reviewed

  
• Molecular analysis of phosphorylated tyrosine-binding proteins in the transduction of proliferation and differentiation signals

  K Nagashima; S Tanaka; S Ota; H Hasegawa; M Matsuda

  BRAIN TUMOR, 1996, Peer-reviewed

  
• Ras signal transduction pathways in PC12 cells.

  S Hattori; M Matsuda; S Nakamura

  JOURNAL OF BRAIN RESEARCH-JOURNAL FUR HIRNFORSCHUNG, 1996, Peer-reviewed

  
• IDENTIFICATION OF RAP1 AS A TARGET FOR THE CRK SH3 DOMAIN-BINDING GUANINE NUCLEOTIDE-RELEASING FACTOR C3G

  T GOTOH; S HATTORI; S NAKAMURA; H KITAYAMA; M NODA; Y TAKAI; K KAIBUCHI; H MATSUI; O HATASE; H TAKAHASHI; T KURATA; M MATSUDA

  MOLECULAR AND CELLULAR BIOLOGY, Dec. 1995, Peer-reviewed

  
• MAPPING OF THE HUMAN C3G GENE CODING A GUANINE-NUCLEOTIDE RELEASING PROTEIN FOR RAS FAMILY TO 9Q34.3 BY FLUORESCENCE IN-SITU HYBRIDIZATION

  S TAKAI; M TANAKA; H SUGIMURA; K YAMADA; Y NAITO; KINO, I; M MATSUDA

  HUMAN GENETICS, Nov. 1994, Peer-reviewed

  
• CRK PROTEIN BINDS TO 2 GUANINE NUCLEOTIDE-RELEASING PROTEINS FOR THE RAS FAMILY AND MODULATES NERVE GROWTH FACTOR-INDUCED ACTIVATION OF RAS IN PC12 CELLS

  M MATSUDA; Y HASHIMOTO; K MUROYA; H HASEGAWA; T KURATA; S TANAKA; S NAKAMURA; S HATTORI

  MOLECULAR AND CELLULAR BIOLOGY, Aug. 1994, Peer-reviewed

  
• BK VIRUS-INFECTION OF THE HUMAN URINARY-TRACT

  T SHINOHARA; M MATSUDA; SH CHENG; J MARSHALL; M FUJITA; K NAGASHIMA

  JOURNAL OF MEDICAL VIROLOGY, Dec. 1993, Peer-reviewed

  
• BOTH THE SH2 AND SH3 DOMAINS OF HUMAN CRK PROTEIN ARE REQUIRED FOR NEURONAL DIFFERENTIATION OF PC12 CELLS

  S TANAKA; S HATTORI; T KURATA; K NAGASHIMA; Y FUKUI; S NAKAMURA; M MATSUDA

  MOLECULAR AND CELLULAR BIOLOGY, Jul. 1993, Peer-reviewed

  
• INSULIN STIMULATES ASSOCIATION OF INSULIN-RECEPTOR SUBSTRATE-1 WITH THE PROTEIN ABUNDANT SRC HOMOLOGY GROWTH-FACTOR RECEPTOR-BOUND PROTEIN-2

  K TOBE; K MATUOKA; H TAMEMOTO; K UEKI; Y KABURAGI; S ASAI; T NOGUCHI; M MATSUDA; S TANAKA; S HATTORI; Y FUKUI; Y AKANUMA; Y YAZAKI; T TAKENAWA; T KADOWAKI

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 1993, Peer-reviewed

  
• STRUCTURE OF 85-KDA SUBUNIT OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE ANALYZED BY USING MONOCLONAL-ANTIBODIES

  S TANAKA; M MATSUDA; S NAGATA; T KURATA; K NAGASHIMA; Y SHIZAWA; Y FUKUI

  JAPANESE JOURNAL OF CANCER RESEARCH, Mar. 1993, Peer-reviewed

  
• STRUCTURAL REQUIREMENT OF CRK SH2 REGION FOR BINDING TO PHOSPHOTYROSINE-CONTAINING PROTEINS - EVIDENCE FROM REACTIVITY TO MONOCLONAL-ANTIBODIES

  M MATSUDA; S NAGATA; S TANAKA; K NAGASHIMA; T KURATA

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 1993, Peer-reviewed

  
• 2 SPECIES OF HUMAN CRK CDNA ENCODE PROTEINS WITH DISTINCT BIOLOGICAL-ACTIVITIES

  M MATSUDA; S TANAKA; S NAGATA; A KOJIMA; T KURATA; M SHIBUYA

  MOLECULAR AND CELLULAR BIOLOGY, Aug. 1992, Peer-reviewed

  
• A GLYCOPROTEIN IN THE PLASMA-MEMBRANE MATRIX AS A MAJOR POTENTIAL SUBSTRATE OF P60V-SRC

  M HAMAGUCHI; M MATSUDA; H HANAFUSA

  MOLECULAR AND CELLULAR BIOLOGY, Feb. 1990, Peer-reviewed

  
• ORIGIN OF THE MEDULLOBLASTOMA EXPERIMENTALLY INDUCED BY HUMAN POLYOMAVIRUS JC

  M MATSUDA; K YASUI; K NAGASHIMA; W MORI

  JOURNAL OF THE NATIONAL CANCER INSTITUTE, Sep. 1987, Peer-reviewed

  
• CYTOPLASMIC TUBULAR INCLUSION IN GANGLIONEUROMA

  M MATSUDA; K NAGASHIMA

  ACTA NEUROPATHOLOGICA, 1984, Peer-reviewed

  

Misc.

• FRETバイオセンサーを用いたin vitroおよびin vivo imaging—In vitro and in vivo imaging with FRET biosensors

  小長谷 有美; 寺井 健太; 松田 道行

  臨床免疫・アレルギー科 = Clinical immunology & allergology / 臨床免疫・アレルギー科編集委員会 編, Apr. 2018

  
• Cell Signal Manipulation in Living Mice by SLIPT

  田原海; 吉川優; 高倉加奈子; 寺井健太; 松田道行; 松田道行; 築地真也

  日本化学会春季年会講演予稿集(Web), 2024

  
• 肝細胞増殖因子による先導細胞運命決定の機序の解明

  寺井健太; 日野直也; 松田樹生也; 松田道行

  金沢大学がん進展制御研究所がんの転移・薬剤耐性に関わる先導的共同研究拠点, 2023

  
• p53によるATMのフィードバック制御:FRETバイオセンサーを用いた解析

  林亜里香; 後藤明弘; 隅山健太; 松田道行; 松田道行; CANDEIAS Marco

  日本分子生物学会年会プログラム・要旨集(Web), 2012

  
• Analysis of the hepatocyte growth factor receptor in regeneration and oncogenesis of the liver

  K. Annen; T. Nojima; Y. Hata; J. Uchino; S. Tanaka; M. Matsuda; E. Tahara; K. Nagashima

  General and Diagnostic Pathology, 1995

  
• FRETバイオセンサー—グリア細胞内・細胞外情報伝達の可視化

  松田 道行; 幸長 弘子

  ファルマシア, 2022

  
• SMART Tgマウスを用いた急性腎障害によるネクロプトーシスのin vivo FRET解析

  村井晋; 隅山健太; 森脇健太; 高倉加奈子; 山口良文; 駒澤幸子; 寺井健太; 松田道行; 中野裕康

  日本Cell Death学会学術集会プログラム抄録集, 2022

  
• ライブイメージングによる内軟骨性骨化におけるCNP/GC-Bシグナルの時空間的制御機構の解析

  廣田圭昭; 八十田明宏; 松田道行

  日本内分泌学会雑誌, 2022

  
• Regulation of C3G Activity by Tyrosine Phosphorylation

  NAKAYA Mie; ICHIBA Tamotu; HASHIMOTO Yuko; OTSUKA Naomi; KURATA Takeshi; MATUDA Mitiyuki

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• CRK-SH3結合性ヌクレオチド交換因子C3Gの機能解析

  服部 成介; 松田 道行

  日本分子生物学会年会プログラム・講演要旨集, Aug. 1996

  
• Ras/ERK MAPKカスケードのダイナミクス

  藤岡亜紀; 寺井健太; 伊藤玲奈; 青木一洋; 中村岳史; 黒田真也; 西田栄介; 松田道行

  日本分子生物学会年会講演要旨集, 2005

  
• FRETを用いた蛋白間相互作用解析

  寺井健太; 松田道行

  分子呼吸器病, 2005

  
• FRETを用いたc-Raf-1の構造変化解析

  寺井健太; 松田道行

  日本癌学会総会記事, 2004

  
• FRETを利用したRafの制御機序の時空間的解析

  寺井健太; 松田道行

  日本癌学会総会記事, 2003

  
• FRETを用いたc-Raf-1の構造変化解析

  寺井健太; 松田道行

  日本分子生物学会年会プログラム・講演要旨集, 2003

  
• Acquisition of spatio-temporal activities of small GTPases

  清川 悦子; 八木 俊輔; 松田 道行

  Cell technology, Dec. 2009

  
• 細胞内シグナル伝達のFRETプローブによる可視化 (特集 がんの光イメージング)

  中村 岳史; 松田 道行

  メディカルバイオ, Nov. 2007

  
• 目で見るバイオ

  樋掛 和宏; 吉崎 尚良; 松田 道行

  バイオサイエンスとインダストリー = Bioscience & industry, 01 Jan. 2006

  
• Visualizing the signal transduction molecules by FRET-based probes

  HIKAKE Kazuhiro; YOSHIZAKI Hisayoshi; MATSUDA MICHIYUKI

  Bioscience & industry, 01 Jan. 2006

  
• Nipponのアダプター分子, Crk

  松田 道行; 平井 久丸; 近藤 科江; 田中 伸哉

  日本分子生物学会年会プログラム・講演要旨集, Aug. 1996

  
• Crk及びCrk SH3結合蛋白による細胞の形態変化の解析

  橋本 裕子; 清川 悦子; 倉田 毅; 松田 道行

  日本分子生物学会年会プログラム・講演要旨集, 01 Aug. 1996

  
• Blo-imaging of the activation of signaling molecules and cytoskeletal molecules

  Mochizuki Naoki; Matsuda Michiyuki; Miyawaki Atsushi

  Circulation journal : official journal of the Japanese Circulation Society, 31 Mar. 2002

  
• 【感染現象 その理解の深化から疾患制御への展望】生体防御機構研究の新展開 貪食過程における低分子量G蛋白質Rac1とRab5の活性変化

  中村 岳史; 北野 正寛; 仲矢 道雄; 長田 重一; 松田 道行

  蛋白質・核酸・酵素, Jun. 2009

  
• Rab5活性のイメージングにより同定されたファゴソーム成熟に必須の制御因子

  北野 正寛; 仲矢 道雄; 中村 岳史; 長田 重一; 松田 道行

  細胞工学, Aug. 2008

  
• Shedding of Necl-5 Causes Evasion of NK Cell Surveillance

  塚本祥子; 一瀬大志; 寺井健太; 松田道行; 松田道行

  日本細胞生物学会大会(Web), 2021

  
• 次世代病理技術講座 第11回 生体イメージングに基づく実験病理学

  寺井健太; 松田道行

  病理と臨床, 2020

  
• 腫瘍免疫のライブイメージング

  松田道行; 松田道行; 一瀬大志; 小西義延; 小西義延; 寺井健太

  日本癌治療学会学術集会(Web), 2020

  
• フェルスター共鳴エネルギー移動の原理に基づく二光子励起用光遺伝学ツールの開発

  金城智章; 寺井健太; 堀田彰一朗; 野村紀通; 隅山健太; 岩田想; 松田道行; 松田道行

  日本細胞生物学会大会(Web), 2019

  
• クラス別学習による細胞画像セグメンテーション

  松月大輔; 堀田一弘; 平松侑樹; 松田道行; 寺井健太; 今西彩子

  日本医用画像工学会大会予稿集(CD-ROM), 2018

  
• ライブイメージングに資する4次元ヒストロジーの創生

  今西彩子; 佐藤雅也; 寺井健太; 隅山健太; 堀田一弘; 松田道行

  日本細胞生物学会大会(Web), 2017

  
• Unleashing mechanical constraint switches growth factor signaling dynamics underlying leader cell specification during collective cell migration

  日野直也; 松田樹生也; 真流玄武; 酒井克也; 酒井克也; 今村龍; 今村龍; 青木一洋; 寺井健太; 平島剛志; 平島剛志; 松本邦夫; 松本邦夫; 松田道行; 松田道行

  日本細胞生物学会大会(Web), 2021

  
• Development of multicolor split-fluorescent proteins labeling techniqe

  石井衛; 寺井健太; 松田道行; 松田道行

  日本細胞生物学会大会(Web), 2021

  
• Development of phycocyanobilin biosynthesizing mice for optogenetic manipulation by red/far-red light

  小鉢健樹; 隅山健太; 青木一洋; 松田道行; 寺井健太

  日本細胞生物学会大会(Web), 2021

  
• Unique extracellular dynamics of EGFR ligands expressed in MDCK cells

  出口英梨子; LIN Shuhao; 岩本亮; 寺井健太; 松田道行

  日本細胞生物学会大会(Web), 2021

  
• イメージングを用いた肺転移防御における免疫逃避機構の解明

  塚本祥子; 一瀬大志; 寺井健太; 松田道行; 松田道行

  日本癌学会学術総会抄録集(Web), 2021

  
• Intercellular communication in vasospasm

  寺井健太; 今西彩子; FAN Chuyun; 松田道行

  日本病理学会会誌, 2021

  
• Molecular activity biosensors based on Foerster resonance energy transfer

  寺井健太; 松田道行

  Optronics, 2021

  
• Visualization of the Receptor Tyrosine kinase (RTK)/Ras/mitogen activated protein (MAP) kinase signaling pathway

  松田道行; 寺井健太

  日本癌学会学術総会抄録集(Web), 2020

  
• Gq-protein-coupled receptor signaling in tumor cells promotes cancer immune evasion

  寺井健太; 小西義延; 松田道行

  日本癌学会学術総会抄録集(Web), 2020

  
• Redundant roles of EGF ligands in the propagation of ERK activation wave and collective cell migration of MDCK cells

  LIN Shuhao; 平山大記; 日野直也; 真流玄武; 岩本亮; 青木一洋; 寺井健太; 松田道行; 松田道行

  日本分子生物学会年会プログラム・要旨集(Web), 2020

  
• 集団細胞遊走における細胞層の自由端依存的なHGF感受性上昇による先導細胞の運命決定

  日野直也; 真流玄武; 青木一洋; 寺井健太; 平島剛志; 平島剛志; 松田道行; 松田道行

  日本分子生物学会年会プログラム・要旨集(Web), 2020

  
• 細胞の集団遊走におけるErbBファミリーの機能

  松田樹生也; 真流玄武; 平山大記; 日野直也; 青木一洋; 寺井健太; 松田道行; 松田道行

  日本分子生物学会年会プログラム・要旨集(Web), 2020

  
• ライブイメージングによるマウスクモ膜下出血時の分子活性

  范楚芸; 今西彩子; 松田道行; 松田道行; 寺井健太

  日本分子生物学会年会プログラム・要旨集(Web), 2020

  
• 肺におけるがん細胞のNK細胞回避機構

  塚本祥子; 一瀬大志; 寺井健太; 松田道行; 松田道行

  日本分子生物学会年会プログラム・要旨集(Web), 2020

  
• プロスタグランジンE2はプロテインキナーゼAの同心円状活性化を引き起こす

  渡部哲也; 寺井健太; 松田道行; 松田道行

  日本分子生物学会年会プログラム・要旨集(Web), 2020

  
• ビリベルジン還元酵素欠損マウスによる近赤外イメージングおよび光遺伝学

  小鉢健樹; 隅山健太; 松田道行; 松田道行; 寺井健太

  日本分子生物学会年会プログラム・要旨集(Web), 2020

  
• The establishment of a tumor microenvironment by tumor derived prostanoids

  寺井健太; 小西義延; 松田道行

  日本病理学会会誌, 2020

  
• Visualization of NK cell-mediated elimination of metastatic tumor cells in the pulmonary capillaries

  一瀬大志; 寺井健太; 松田道行; 松田道行

  日本癌学会学術総会抄録集(Web), 2019

  
• 長波長蛍光タンパク質を用いたFRETバイオセンサーの開発

  渡部哲也; 松田道行; 松田道行; 寺井健太

  日本分子生物学会年会プログラム・要旨集(Web), 2019

  
• 抗腫瘍免疫応答の可視化

  寺井健太; 一瀬大志; 松田道行; 松田道行

  日本病理学会会誌, 2019

  
• 蛍光生体イメージングの最前線

  寺井健太; 松田道行

  月刊細胞, 2018

  
• タンパク質・核酸の分子修飾 II.細胞質/オルガネラでの分子修飾 細胞内シグナル リン酸化(セリオ/スレオニン)

  寺井健太; 松田道行

  生体の科学, 2018

  
• FRETバイオセンサーを用いたin vitroおよびin vivo imaging

  小長谷有美; 寺井健太; 松田道行

  月刊臨床免疫・アレルギー科, 2018

  
• Motesanib（VEGFR阻害薬）は血管内皮細胞PKAを活性化し血管透過性を抑制する

  松田道行

  がん分子標的治療, Sep. 2017

  
• Visualization of signal transduction by FRET imaging

  寺井 健太; 松田 道行

  医学のあゆみ, 29 Jul. 2017

  
• Intercellular propagation of ERK MAP kinase signal transduction

  青木 一洋; 平塚 徹; 松田 道行

  生体の科学, Mar. 2016

  
• 輝く : 日本人による発見と新規開発(Vol.25)SH2ドメインを介するチロシンリン酸化依存性蛋白質間相互作用

  松田 道行

  医学のあゆみ, 27 Feb. 2016

  
• 細胞シグナル操作法 I.分子からみたシグナル操作法 2.Gタンパク質 Ras/Rap

  小松直貴; 松田道行

  生体の科学, Oct. 2015, Invited

  
• Visualization of ERK and PKA activities in the tumor microenvironment comprising of lung-metastasized 4T1 murine breast tumor cells

  Yuji Kamioka; Michiyuki Matsuda

  CANCER RESEARCH, Jan. 2015

  
• システム神経科学スプリングスクール2015開催報告

  中江 健; 松田 道行; 石井 信; 本田 直樹; 浦久保 秀俊; 山尾 将隆; 近藤 洋平; 塚田 祐基; 小山 雅典; 村上 陽平; 松田 哲也

  日本神経回路学会誌, 2015

  
• Constitutively-active HRAS suppresses stochastic Erk activity pulses in Madin-Darby canine kidney cells

  Noriyuki Kawabata; Michiyuki Matsuda

  MOLECULAR CANCER RESEARCH, Dec. 2014

  
• Inner ear hair cell-specific Cdc42-KO mice demonstrate progressive hearing loss by impaired actin turnover in stereocilia and apical junctions

  Takashi Nakamura; Takehiko Ueyama; Hirofumi Sakaguchi; Akihiro Goto; Shigefumi Morioka; Shigenobu Yonemura; Yasuo Hisa; Michiyuki Matsuda; Atsu Aiba; Naoaki Satio

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014

  
• In vivo imaging of ERK activity of mouse breast cancer cells reveals heterogeneity in response to anti-cancer drugs and tumor forming capacity

  Yuka Kumagai; Michiyuki Matsuda

  CANCER RESEARCH, Oct. 2013

  
• Analysis of molecular mechanisms underlying colon cancer development by 3D culture system

  Atsuro Sakurai; Masamichi Imajo; Michiyuki Matsuda

  CANCER RESEARCH, Oct. 2013

  
• ポストゲノムプロジェクトとオーミクス研究の潮流 8.蛍光生体イメージングを用いてがん細胞の個性に迫る

  幸長弘子; 青木一洋; 松田道行

  実験医学, 10 Sep. 2013

  
• Visual Screening with Live Cell Fluorescence Imaging

  八木 俊輔; 川越 鳴海; 松田 道行

  細胞工学, 2013

  
• Live imaging of transgenic mice expressing FRET biosensors

  Yuji Kamioka; Kenta Sumiyama; Rei Mizuno; Michiyuki Matsuda

  Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, 2013, Peer-reviewed

  
• 「蛍光生物学」の最前線 5‐1 FRETバイオセンサーの最近の進歩

  青木一洋; 松田道行

  Dojin News, 05 Apr. 2012

  
• Visualization of signal transduction by FRET biosensors in living cells

  水野 礼; 清川 悦子; 松田 道行

  最新医学, Oct. 2011

  
• Processive phosphorylation of ERK MAP kinase in mammalian cells

  Kazuhiro Aokia; Masashi Yamada; Katsuyuki Kunida; Shuhei Yasuda; Michiyuki Matsuda

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2011, Peer-reviewed

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• Rho-Family GTPase Activity in Invading Mammary Tumor Cells Visualized by Two-Photon Excitation Laser Scanning Microscopy

  Y. Kamioka; M. Matsuda

  CANCER RESEARCH, Dec. 2010

  
• 二光子励起蛍光顕微鏡及びFRET imagingを用いたグリオブラストーマ浸潤機構の解析(Analysis of glioblastoma invasion by two-photon excitation fluorescence microscopy and FRET microscopy)

  平田 英周; 幸長 弘子; 荒川 芳輝; 宮本 享; 松田 道行

  日本癌学会総会記事, Aug. 2010

  
• 二光子励起蛍光顕微鏡によるglioblastoma浸潤機構のin vivo解析

  荒川 芳輝; 平田 英周; 宮本 享; 松田 道行

  Brain Tumor Pathology, May 2010

  
• Rap1B plays an instructive role in neuronal polarization through RalA and Nore1A in addition to PI3-kinase

  Takeshi Nakamura; Akihiro Goto; Michiyuki Matsuda; Tatsuo Kinashi

  NEUROSCIENCE RESEARCH, 2010

  
• FRET analysis of differences in signaling mechanism between dbcAMP- and NGF-induced neuritogenesis in PC12D cells

  Akihiro Goto; Takeshi Nakamura; Mikio Hoshino; Michiyuki Matsuda

  NEUROSCIENCE RESEARCH, 2010

  
• Rho‐family GTPaseによるグリオブラストーマ浸潤制御

  平田英周; 幸長弘子; 荒川芳輝; 宮本享; 松田道行

  日本脳腫瘍学会プログラム・抄録集, 2010

  
• 二光子励起蛍光顕微鏡及びFRET imagingを用いたグリオブラストーマ浸潤機構の解析(Analysis of glioblastoma invasion by two-photon excitation fluorescence microscopy and FRET microscopy)

  平田 英周; 荒川 芳輝; 松田 道行

  日本癌学会総会記事, Aug. 2009

  
• SPATIOTEMPORAL ACTIVATION OF Rac1 FOR ENGULFMENT OF APOPTOTIC CELLS

  Michio Nakaya; Masahiro Kitano; Michiyuki Matsuda; Shigekazu Nagata

  JOURNAL OF PHYSIOLOGICAL SCIENCES, 2009

  
• Differences in signaling mechanism and morphological change between dbcAMP- and NGF-induced neuritogenesis in PC12D cells

  Akihiro Goto; Takeshi Nakamura; Michiyuki Matsuda

  NEUROSCIENCE RESEARCH, 2009

  
• 二光子励起蛍光顕微鏡及びFRET imagingを用いたグリオブラストーマ浸潤機構の解析

  平田英周; 荒川芳輝; 宮本享; 松田道行

  日本脳腫瘍学会プログラム・抄録集, 2009

  
• FRET imaging and in silico analysis of nerve growth factor-induced neurite outgrowth

  T. Nakamura; K. Aoki; M. Matsuda

  INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, Dec. 2008

  
• Spatiotemporal activation of Rac1 for engulfment of apoptotic cells

  Michio Nakaya; Masahiro Kitano; Michiyuki Matsuda; Shigekazu Nagata

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jul. 2008, Peer-reviewed

  
• Analysis of signal transduction of neuritogenesis using FRET imaging

  中村 岳史; 青木 一洋; 松田 道行

  The Cell, Apr. 2008

  
• FRET imaging and in silico analysis of NGF-induced neurite outgrowth signaling

  Takeshi Nakamura; Kazuhiro Aoki; Michiyuki Matsuda

  NEUROSCIENCE RESEARCH, 2008

  
• FRETの基礎と応用(D.GFPイメージング)

  中村 岳史; 青木 一洋; 松田 道行

  組織細胞化学, 10 Jul. 2007

  
• 蛋白質の時空間情報--シミュレーション構築のための必須パラメータを求めて (第1土曜特集 システム生物医学) -- (システム生物医学のための方法論)

  松田 道行; 青木 一洋

  医学のあゆみ, 02 Dec. 2006

  
• 細胞遊走・浸潤におけるRho/mDia1情報伝達系の制御

  山名 則和; 荒川 芳輝; 西野 共逹; 黒川 量雄; 丹治 正大; ジェームズ・モニペニー; 石崎 敏理; 尾藤 晴彦; 野崎 和彦; 橋本 信夫; 松田 道行; 成宮 周

  日本癌学会総会記事, Sep. 2006

  
• FRETプローブによるシグナル伝達分子の時空間的解析 (特集 プロテオミクスの細胞機能解析への挑戦)

  青木 一洋; 松田 道行

  細胞工学, Jun. 2006

  
• RhoファミリーG蛋白質の活性化イメージング (細胞骨格と接着) -- (Rhoファミリー)

  吉崎 尚良; 望月 直樹; 松田 道行

  蛋白質核酸酵素, May 2006

  
• Dynamics of Rho-family G proteins as visualized with FRET-based probes

  YOSHIZAKI Hisayoshi; AOKI Kazuhiro; MOCHIZUKI Naoki; MATSUDA Michiyuki

  Folia Pharmacologica Japonica, 01 Aug. 2005

  
• Localized RhoA activation as a requirement for the induction of membrane ruffling

  Kazuo Kurokawa; Michiyuki Matsuda

  CELL STRUCTURE AND FUNCTION, Jun. 2005

  
• Development of FRET-based probes for r-ras activation and R-Ras activation at Early/Recycling Endosomes

  Akiyuki Takaya; Takahiro Kamio; Michitaka Masuda; Naoki Mochizuki; Hirofumi Sawa; Mami Satoh; Kazuo Nagashim; Akiko Mizutani; Akira Matsuno; Michiyuki Matsuda

  CELL STRUCTURE AND FUNCTION, Jun. 2005

  
• Spatio-temporal regulation of RhoA activity in living cells

  K Kurokawa; M Matsuda

  MOLECULAR BIOLOGY OF THE CELL, Nov. 2004

  
• A novel dynamin-associating molecule, formin-binding protein 17, induces tubular membrane invaginations and participates in endocytosis

  Y Kamioka; S Fukuhara; M Masuda; H Sawa; K Nagashima; M Matsuda; N Mochizuki

  MOLECULAR BIOLOGY OF THE CELL, Nov. 2004

  
• Local accumulation of PIP3 at plasma membrane recruits Vav2/Vav3 to activate Rac1/Cdc42 and to initiate outgrowth in NGF-stimulated PC12 cells

  K Aoki; T Nakamura; M Matsuda

  MOLECULAR BIOLOGY OF THE CELL, Nov. 2004

  
• Roles played by a subset of integrin-signaling molecules in cadherin-based cell-cell adhesion

  Hajime Yano; Yuichi Mazaki; Kazuo Kurokawa; Steven Hanks; Michiyuki Matsuda; Hisataka Sabe

  CELL STRUCTURE AND FUNCTION, May 2004

  
• Signal transduction pathways as visualized by GFP-based FRET probes

  Michiyuki Matsuda

  CELL STRUCTURE AND FUNCTION, May 2004

  
• RalA activation at nascent lamellipodia of EGF-stimulated Cos7 cells and migrating MDCK cells

  Akiyuki Takaya; Yusuke Ohba; Kazuo Kurokawa; Michiyuki Matsuda

  CELL STRUCTURE AND FUNCTION, May 2004

  
• ネクチンによる細胞間接着の形成機構(II):Vav2の機能と作用機構

  福山泰平; 清水一也; 福原達朗; 川勝智生; 南有紀子; 中村岳史; 松田道行; 高井義美

  日本分子生物学会年会プログラム・講演要旨集, 25 Nov. 2003

  
• ネクチンによる細胞間接着の形成機構(I):c‐Srcの機能と作用機構

  川勝智生; 清水一也; 福原達朗; 福山泰平; 山田知広; 中村岳史; 松田道行; 高井義美

  日本分子生物学会年会プログラム・講演要旨集, 25 Nov. 2003

  
• ネクチン(2):E‐カドヘリン依存性細胞間接着形成の制御機構

  星野崇; 清水一也; 本田知之; 川勝智生; 福山泰平; 中村岳史; 松田道行; 高井義美

  日本癌学会総会記事, 25 Aug. 2003

  
• 浮遊細胞特異的に発現するCDM‐family蛋白 DOCK2の機能の解析

  前田才恵; 西原広史; 田中伸哉; 松田道行; 沢洋文; 長嶋和郎

  日本分子生物学会年会プログラム・講演要旨集, 25 Nov. 2000

  
• Activation of the ERK/MAPK pathway by an isoform of Rap1gap associated with G alpha I

  N Mochizuki; Y Ohba; K Nagashima; A Endo; M Matsuda

  CIRCULATION, Oct. 2000

  
• 腫よう組織における前癌遺伝子産物CRKの発現と細胞増殖能に関する分子病理学的解析

  西原広史; 田中伸哉; 清水道生; 沢洋文; 松田道行; 長嶋和郎

  Jpn J Cancer Res, 01 Sep. 2000

  
• ヒト腫よう組織における前癌遺伝子産物Crkの発現解析 免疫組織学的検討及びPCR‐SSCP法を用いた遺伝子変異の解析

  西原広史; 田中伸哉; 松田道行; 清水道生; 長嶋和郎

  日本病理学会会誌, 10 Mar. 2000

  
• A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia (vol 95, pg 13278, 1998)

  H Kawasaki; GM Springett; S Toki; JJ Canales; P Harlan; JP Blumenstiel; EJ Chen; IA Bany; N Mochizuki; A Ashbacher; M Matsuda; DE Housman; AM Graybiel

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 1999

  
• The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway

  F Dolfi; M Garcia-Guzman; M Ojaniemi; H Nakamura; M Matsuda; K Vuori

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 1998, Peer-reviewed

  
• Infectivity of HIV

  MATSUDA Michiyuki

  計測と制御 = Journal of the Society of Instrument and Control Engineers, Oct. 1998

  
• A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

  H Kawasaki; GM Sprihtgett; S Toki; JJ Canales; P Harlan; JP Blumenstiel; EJ Chen; IA Bany; N Mochizuki; A Ashbacher; M Matsuda; DE Housman; AM Graybiel

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 1998, Peer-reviewed

  
• CrkII signals from epidermal growth factor receptor to Ras

  S KizakaKondoh; M Matsuda; H Okayama

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 1996, Peer-reviewed

  
• HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE - ENHANCEMENT OF ACTIVITY BY INTERACTION WITH CELLULAR TOPOISOMERASE-I

  H TAKAHASHI; M MATSUDA; A KOJIMA; T SATA; T ANDOH; T KURATA; K NAGASHIMA; WW HALL

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jun. 1995, Peer-reviewed

  
• C3G, A GUANINE NUCLEOTIDE-RELEASING PROTEIN EXPRESSED UBIQUITOUSLY, BINDS TO THE SRC HOMOLOGY-3 DOMAINS OF CRK AND GRB2 ASH PROTEINS

  S TANAKA; T MORISHITA; Y HASHIMOTO; S HATTORI; S NAKAMURA; M SHIBUYA; K MATUOKA; T TAKENAWA; T KURATA; K NAGASHIMA; M MATSUDA

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Apr. 1994, Peer-reviewed

  

Presentations

• Cell-to-cell communications as visualized by FRET biosensors

  Michiyuki Matsuda

  Research Seminar, Center for Molecular Medicine, UMC Utrecht, 12 Oct. 2022, Invited

  
• Redundant and specific roles of epidermal growth factor receptors and their ligands in collective cell migration

  Michiyuki Matsuda

  IMPRS Distinguished Guests Seminar Series, 11 Oct. 2022, Invited

  
• The Quantitative Landscape of ERK MAPK Signal Dynamics in Patient-Derived Pancreatic Cancer Organoids

  Shoko Tsukamoto; Akihito Machinaga; Nobuyuki Kakiuchi; Seishi Ogawa; Hiroshi Seno; Shigeki Higashiyama; Michiyuki Matsuda; Toru Hiratsuka

  The 7th JCA-AACR Special Joint Conference, 08 Jul. 2022

  
• Split蛍光タンパク質を用いた多重蛍光ラベル技術

  石井衛; 金城智章; 寺井健太; 松田道行

  第74回日本細胞生物学会大会, 28 Jun. 2022

  
• EXTRACELLULAR DYNAMICS OF EGFR LIGANDS CONTROLS THE INTERCELLULAR PROPAGATION OF ERK ACTIVATION

  Eriko Deguchi; Lin Shuhao; Kimiya Matsuda; Daiki Hirayama; Shinya Tsukiji; Kenta Terai; Michiyuki Matsuda

  FASEB The Protein Kinases and Phosphorylation Conference: Mechanisms to Therapeutics, 20 Jun. 2022

  
• 細胞間情報伝達の可視化に基づく 病態解明

  松田道行

  第29回肝細胞研究会, 25 Aug. 2022, Invited

  
• FRET バイオセンサーを使った細胞間コミュニケーションの可視化

  松田 道行

  学術変革領域研究（A） 新興硫黄生物学が拓く生命原理変革（硫黄生物学） 第2回 領域会議, 06 Aug. 2022, Invited

  
• FRETバイオセンサーと蛍光寿命顕微鏡

  松田道行

  LEICA Webセミナー, 19 Oct. 2021

  
• 「実写版」はたらく細胞

  松田道行

  第１２回形態科学シンポジウム：生命科学の魅力を語る高校生のための集い 〜分子と細胞を観る楽しさ〜, 20 Aug. 2021, Invited

  
• 生体イメージングを用いた腫瘍細胞内カルシウムシグナルによる微小環境形成機構の解析

  寺井健太; 小西義延; 松田道行

  42回炎症再生医学会, 07 Jul. 2021

  
• 肺転移がん細胞におけるNecl-5の欠損は免疫回避の一因である

  塚本 祥子; 一瀬 大志; 寺井 健太; 松田 道行

  第73回 日本細胞生物学会大会, 29 Jun. 2021

  
• MDCK細胞の集団遊走および増殖におけるErbBファミリー受容体の機能の重畳性

  松田樹生也; 平山大記; 林 抒豪; 真流玄武; 青木一洋; 寺井健太; 日野直也; 松田道行

  第73回日本細胞生物学会大会, 29 Jun. 2021

  
• MDCK細胞に発現するEGFRリガンドの分子特徴的な細胞外動態

  出口英梨子、林 抒豪、岩本亮、寺井健太、松田道行

  第73回日本細胞生物学会大会, 29 Jun. 2021

  
• Intercellular communication during collective cell migration

  Michiyuki Matsuda

  2021 INSIDE (Insights in Signaling Dynamics and Encoding), 03 Jun. 2021, Invited

  
• FRETバイオセンサーを使った細胞間コミュニケーションの可視化

  松田道行

  大阪大学・ニコンイメージングセンターオー プン記念シリーズセミナー第5回, 15 Mar. 2021, Invited

  
• Intravital imaging identifies VEGF-TXA2 axis as a critical promoter of ​PGE2 secretion from tumor cells and immune evasion

  Yoshinobu Konishi; Hiroshi Ichise; Tetsuya Watabe; Choji Oki; Shinya Tsukiji; Yoko Hamazaki; Yasuhiro Murakawa; Akifumi Takaori-Kondo; Kenta Terai, MD; Michiyuki Matsuda

  The virtual meeting Tumor Metabolism and the Microenvironment, 25 Jan. 2021

  
• ERK activation waves mediated by intercellular mechanical forces underlie long-range guidance for collective cell migration

  Naoya Hino; Michiyuki Matsuda; Tsuyoshi Hirashima

  ASCB｜EMBO 2019 meeting, 07 Dec. 2020

  
• 肺におけるがん細胞のNK細胞回避機構

  Shoko Tsukamoto; Hiroshi Ichise; Kenta Terai; Michiyuki Matsuda

  第43回 日本分子生物学会年会, 02 Dec. 2020

  
• Redundant roles of EGF ligands in the propagation of ERK activation wave and collective cell migration of MDCK cells

  LIN SHUHAO; Kenta Terai; Michiyuki Matsuda

  The 43rd Annual Meeting of the Molecular Biology Society of Japan, 02 Dec. 2020

  
• High resolution live imaging revealed photoreceptor-specific response to metabolic challenge and unexpected metabolic regulation by lactate

  Jiazhou He; Shinya Sato; Masamichi Yamamoto; Michiyuki Matsuda

  The 43rd Annual Meeting of the Molecular Biology Society of Japan, 02 Dec. 2020

  
• HB-EGF distribution and physiological function in the intercellular communication

  Eriko Deguchi; Ryo Iwamoto; Kenta Terai; Michiyuki Matsuda

  第43回日本分子生物学会年会, 02 Dec. 2020

  
• Enhanced fluorescence of near-infrared fluorescent proteins by the deficiency of biliverdin reductase-A gene in vivo

  Kenju Kobachi; Kenta Sumiyama; Michiyuki Matsuda; Kenta Terai

  第43回日本分子生物学会年会, 02 Dec. 2020

  
• Radial spread of Protein kinase A activation is mediated by Prostaglandin E2

  渡部 哲也; 寺井 健太; 松田 道行

  第43回日本分子生物学会年会, 02 Dec. 2020

  
• Analysis of protein kinase A regulation by C-type natriuretic peptide in endochondral ossification

  Keisho Hirota; Akihiro Yasoda; Michiyuki Matsuda

  第43回 日本分子生物学会年会, 02 Dec. 2020

  
• Leader cell specification mediated by free edge-dependent HGF-sensitization during collective cell migration

  日野直也; 真流玄武; 青木一洋; 寺井健太; 平島剛志; 松田道行

  第43回日本分子生物学会年会, 02 Dec. 2020

  
• Gq-protein-coupled receptor signaling in tumor cells promotes cancer immune evasion

  Kenta Terai; Yoshinobu Konishi; Hiroshi Ichise; Tetsuya Watabe; Yukari Sando; Takefumi Kondo; Choji Oki; Shinya Tsukiji; Yoko Hamazaki; Yasuhiro Murakawa; Akifumi Takaori-Kondo; Michiyuki Matsuda

  AACR Virtual Special Conference on Tumor Heterogeneity: From Single Cells to Clinical Impact, 17 Sep. 2020

  
• Rhodopsin-mediated Light-off-induced Protein Kinase A Activation in Mouse Rod Photoreceptor Cells. （邦題：マウス桿体視細胞においてロドプシンを介するが光オフで生じるプロテインキナーゼAの活性化）

  佐藤慎哉; 山下高廣; 松田道行

  第58回日本生物物理学会年会, 16 Sep. 2020

  
• Biliverdin reductase-A遺伝子欠損マウスにおける近赤外蛍光タンパク質の蛍光強度上昇

  小鉢健樹; 隅山健太; 松田道行; 寺井健太

  2020年度若手支援技術講習会, 11 Sep. 2020

  
• Dynamic change of molecules and inflammatory cells in vasospasm induced by subarachnoid hemorrhage

  Fan Chuyun; Kenta Terai; Michiyuki Matsuda

  ABiS International Symposium, 17 Feb. 2020

  
• Development of FRET biosensors comprised of longer wavelength fluorescence proteins

  LIN SHUHAO; Kenta Terai; Michiyuki Matsuda

  ABiS International Symposium, 17 Feb. 2020

  
• Visualization of immune surveillance by NK cells against metastatic tumor cells within the pulmonary capillaries

  Hiroshi Ichise; Kenta Terai; Michiyuki Matsuda

  日本免疫学会, 11 Dec. 2019

  
• Development of FRET biosensors comprising long wavelength fluorescent proteins

  渡部 哲也; 松田 道行; 寺井 健太

  第42回日本分子生物学会年会, 03 Dec. 2019

  
• 多光子顕微鏡観察で見出された光照射後の暗黒下で起こる 視細胞PKA活性化

  佐藤慎哉; 松田道行

  異分野融合による次世代光生物学研究会, 07 Nov. 2019

  
• "Whole-organ imaging for cochlear duct morphogenesis – Differential growth hypothesis for bending force generation"

  Mamoru Ishii; Tsuyoshi Hirashima; Michiyuki Matsuda

  Resonance Bio International Symposium, 30 Oct. 2019

  
• Enhanced fluorescence of near-infrared fluorescent proteins by the deficiency of biliverdin reductase-A gene in vivo

  Kenju Kobachi; Kenta Terai; Michiyuki Matsuda

  Resonance Bio International Symposium, 30 Oct. 2019

  
• Cancer cell-derived prostanoids shape the pro-tumor microenvironment, enhancing calcium signaling in cancer cells

  Yoshinobu Konishi; Kenta Terai; Michiyuki Matsuda

  Resonance Bio International Symposium, 30 Oct. 2019

  
• Real-time evaluation of ROCK activation by a Förster resonance energy transfer-based biosensor during vasospasm in living mice

  Ayako Imanishi; Kenta Sumiyama; Michiyuki Matsuda; Kenta Terai

  EMBO_Seeing is Believing, 09 Oct. 2019

  
• Visualization of immune surveillance by NK cells against metastatic tumor cells within the pulmonary capillaries

  Hiroshi Ichise; Kenta Terai; Michiyuki Matsuda

  The 18th Meeting of Society for natural immunity, 30 Sep. 2019

  
• Visualization of rapid elimination of hematogenous metastatic tumor cells by NK cells in the lung

  Hiroshi Ichise; Kenta Terai; Michiyuki Matsuda

  日本癌学会, 26 Sep. 2019

  
• ERK activation waves mediated by intercellular mechanical signals during collective cell migration

  Naoya Hino; Xavier Trepat; Michiyuki Matsuda; Tsuyoshi Hirashima

  第57回日本生物物理学会年会, 24 Sep. 2019

  
• Mechano-chemical coupling via ERK signal for repetitive branching morphogenesis of lung epithelial sheet

  Tsuyoshi Hirashima; Takuya Yoshida; Michiyuki Matsuda

  EMBL Symposium: Mechanical Forces in Development, 03 Jul. 2019

  
• Resonance between FRET-biosensors and optogenetic tools

  Kenta Terai

  第71回日本細胞生物学会大会, 24 Jun. 2019

  
• Identification of EGF-Family ligands and ErbB-family receptors required for Collective Cell Migration of MDCK cells.

  Daiki Hirayama; Naoya Hino; Tsuyoshi Hirashima; Kazuhiro Aoki; Gembu Maryu; Iwamoto Ryo; Kenta Terai; Michiyuki Matsuda

  第71回日本細胞生物学会大会, 24 Jun. 2019

  
• Control of AMP-Activated Protein Kinase by Optogenetic Protein Clustering

  Kenju Kobachi; Kenta Terai; Michiyuki Matsuda

  "第19回日本蛋白質学会年会 第71回日本細胞生物学会大会 合同年次大会", 24 Jun. 2019

  
• "フェルスター共鳴エネルギー移動の原理に基づくニ光子励起用光遺伝学ツールの開発 "

  金城 智章; 寺井 健太; 堀田 彰一朗; 野村 紀通; 隅山 健太; 岩田 想; 富樫かおり; 松田 道行

  第19回日本蛋白質科学会年会/第71回日本細胞生物学会大会 合同年次大会, 23 Jun. 2019

  
• Förster resonance energy transfer-assisted photoactivation of CRY2 for the optical control of protein interactions by two-photon excitation microscopy

  Tomoaki Kinjo; Kenta Terai; Shoichiro Horita; Norimichi Nomura; Kenta Sumiyama; Kaori Togashi; So Iwata; Michiyuki Matsuda

  Next Generation Protein Therapeutics & Bioconjugates Summit, 18 Jun. 2019

  
• マウスの桿体視細胞が光でProtein Kinase Aを活性化する仕組みは何なのか？

  佐藤慎哉; 松田道行

  日本動物学会近畿支部 春の発表会, 11 May 2019

  
• Visualization of an anti-tumor immune response

  寺井健太; 一瀬大志; 松田道行

  第108回日本病理学会総会, 09 May 2019

  
• Control of AMP-activated protein kinase by optogenetic protein clustering

  Kenju Kobachi; Kenta Terai; Michiyuki Matsuda

  18th International Joint Mini-symposium on molecular and cell biology, 02 May 2019

  
• ERK activation waves mediated by intercellular mechanical signaling during collective cell migration

  Naoya Hino; Michiyuki Matsuda; Tsuyoshi Hirashima

  17th International Student Seminar, 06 Mar. 2019

  
• Cell cycle-dependent myoblast migration during muscle regeneration.

  Yumi Konagaya; Kenta Terai; Michiyuki Matsuda

  17th International Student Seminar, 06 Mar. 2019

  
• A Challenge of Generating Distal Tips in Developing Lung by Optogenetic Control of ERK

  Takuya Yoshida; Michiyuki Matsuda; Tsuyoshi Hirashima

  17th International Student Seminar, 06 Mar. 2019

  
• Investigation for Functions of EGF Family ligands in Collective Cell Migration.

  Daiki Hirayama; Kenta Terai; Michiyuki Matsuda

  "The 66th NIBB Conference ABiS International Symposium", 17 Feb. 2019

  
• Control of AMP-Activated Protein Kinase by Optogenetic Protein Clustering

  Kenju Kobachi; Kenta Terai; Michiyuki Matsuda

  "The 66th NIBB Conference ABiS International Symposium ", 17 Feb. 2019

  
• FRETバイオセンサーと光遺伝学の両立

  寺井健太

  "平成30年度【先端モデル動物支援プラットフォーム】成果発表会 ", 30 Jan. 2019

  
• 腸上皮における細胞増殖シグナルの動態とその生理的意義

  今城 正道; 牟田 優; 松田 道行

  文部科学省 科学研究費補助金 新学術領域研究（研究領域提案型）細胞社会ダイバーシティーの統合的解明と制御 第3回公開シンポジウム「1細胞統合解析を駆使した組織内ダイバーシティー解明への挑戦」,, 15 Jan. 2019

  
• 二光子顕微鏡によるマウス単離網膜での一細胞キナーゼ活性測定

  佐藤慎哉; 松田道行

  第89回日本動物学会札幌大会（中止）→東京大学での代替行事, 09 Dec. 2018

  
• Live-cell FRET imaging reveals a role of ERK activity dynamics in thymocyte motility

  Yoshinobu Konishi; Kenta Terai; Takaya Abe; Yoko Hamazaki; Akifumi Takaori-Kondo; Michiyuki Matsud

  "The 60th American Society of Hematology Annual Meeting and Exhibition ", 01 Dec. 2018

  
• "ERK活性を介したメカノ・ケミカルフィードバック制御による肺上皮の分岐形態形成 "

  平島剛志; 吉田琢; 哉; 松田道行

  日本分子生物学会, 28 Nov. 2018

  
• Development of FRET biosensors comprised of longer wavelength fluorescence proteins

  Tetsuya Watabe; Kenta Terai; Michiyuki Matsuda

  International Meeting on Optical Biosensors, 15 Nov. 2018

  
• The strength of ERK activation in NK cells correlates with the fate of conjugated target cells.

  Hiroshi Ichise; Kenta Terai; Michiyuki Matsuda

  日本癌学会, 27 Sep. 2018

  
• "FRETバイオセンサーを用いたin vivoイメージングで紐解く血管平滑筋収縮におけるROCK活性の動態 "

  今西彩子; 寺井健太; 松田道行

  "平成30年度【先端モデル動物支援プラットフォーム】若手支援技術講習会 ", 06 Sep. 2018

  
• Live imaging of extracellular signal-regulated kinase and protein kinase A activities during thrombus formation in mice expressing biosensors based on Förster resonance energy transfer

  T. HIRATSUKA; T. SANO; H. KATO; N; KOMATSU; M. IMAJO; Y. KAMIOKA; K. SUMIYAMA; F . BANNO; T. MIYATA; M. MATSUDA

  "平成30年度【先端モデル動物支援プラットフォーム】成果発表会 ", 27 Jul. 2018

  
• Development of a cryptochrome-based optogenetic dimerizer for two-photon excitation based on Förster resonance energy transfer

  Tomoaki Kinjo; Kenta Terai; Michiyuki Matsuda

  Optogenetic Approaches to Understanding Neural Circuits and Behavior, 16 Jul. 2018

  
• Timelapse FRET imaging reveals the correlation between the strength of ERK activation in NK cells and the fate of conjugated target cells.

  Hiroshi Ichise; Kenta Terai; Michiyuki Matsuda

  The 17th Meeting of Society for natural immunity, 28 May 2018

  

Books and Other Publications

Industrial Property Rights

• 特許第3842729号, WO2002-014373, JP2001006967, 低分子量GTP結合タンパク質の活性モニタータンパク質

  松田 道行

  
• 特開平7-250687, 特願平6-069861, ヒトアデノシン5’-ホスホ硫酸キナーゼのDNA断片及びDNAプローブ

  松田 道行; 恩田 昌明; 中島 宏

  
• 特開平6-253886, 特願平4-260215, CRKタンパクに対するモノクローナル抗体と、この 抗体を産生するハイブリドーマ株

  松田 道行; 倉田 毅

  
• 特許第2786068号, 特開平6-253886, 特願平4-260215, CRKタンパクに対するモノクローナル抗体と、この抗体を産生するハイブリドーマ株

  松田 道行; 倉田 毅

  
• 特許第2937757号, 特開平7-051073, 特願平6-130699, C3G蛋白遺伝子のcDNA

  松田 道行; 倉田 毅

  
• ヒトアデノシン5’-ホスホ硫酸キナーゼのDNA断片およびDNAプローブ

  
• 特許第3053539号, 特開平8-196277, 特願平7-006775, DOCK180蛋白遺伝子のcDNA

  松田 道行; 倉田 毅

  
• 特開2003-024078, 特願2001-218756, 三量体型G蛋白質の活性モニター分子

  松田 道行; 望月 直樹

  

Awards

• 29 Apr. 2023

  紫綬褒章
• 15 Nov. 2008

  SGH Foundation, Sagawa Cancer Research Grant Award
• 28 Oct. 2011

  Mochida Memorial Foundation for Medical and Pharmaceutical Research, Mochida Academic Award
• 16 Feb. 2018

  Nakatani Foundation, Nakatani Prize
• 10 May 2019

  The Japanese Society of Pathology, Japan Pathology Award

Media Coverage

• 肺へ転移 隠れて免疫逃避

  読売新聞, 夕刊8ページ, 10 Mar. 2022, Paper

  
• 分子活性化の伝搬解明

  日刊工業新聞, 18ページ, 04 Jun. 2020, Paper

  

External funds: Kakenhi

• Visualization of interglial signal transduction

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  松田 道行

  From 19 Nov. 2020, To 31 Mar. 2025, Granted

  上皮細胞増殖因子;FRETバイオセンサー;ERKマップキナーゼ;細胞集団運;グリア;多光子顕微鏡;近赤外蛍光タンパク質;ERK MAPキナーゼ;細胞間情報伝達;ERK;マップキナーゼ;蛍光タンパク質;蛍光イメージング;FRET;バイオセンサー

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-20H05898/
• Glia decoding: deciphering information critical for brain-body interactions

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  The University of Tokyo

  岡部 繁男

  From 19 Nov. 2020, To 31 Mar. 2025, Granted

  グリア;イメージング;神経回路;脳末梢連関;体内環境

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-20H05894/
• Collective cell migration by activation wave of growth factor signal transduction cascade

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields

  Kyoto University

  松田 道行

  From 01 Apr. 2019, To 31 Mar. 2024, Granted

  上皮細胞増殖因子;FRETバイオセンサー;ERKマップキナーゼ;細胞集団運動;ERK;マップキナーゼ;上皮細胞増殖因子受容体;ERK　MAPキナーゼ;細胞生物学;顕微鏡;バイオセンサー;細胞運動

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H00993/
• Advanced Bioimaging Support

  Grant-in-Aid for Scientific Research on Innovative Areas ― Platforms for Advanced Technologies and Research Resources

  National Institute for Physiological Sciences

  Masanobu KANO

  From 01 Apr. 2016, To 31 Mar. 2022, Project Closed

  イメージング;光学顕微鏡;電子顕微鏡;磁気共鳴画像;画像解析;トレーニング;支援活動;科研費取得者;科研費;機能的磁気共鳴画像

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H06280/
• Accelerating international cooperative researches

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Institute of Physical and Chemical Research

  Atsushi Miyawaki

  From 06 Nov. 2015, To 31 Mar. 2021, Project Closed

  バイオイメージング;画像処理;ワークショップ;シンポジウム;顕微鏡技術;FRET;ケミカルバイオロジー;画像解析

  https://kaken.nii.ac.jp/grant/KAKENHI-INTERNATIONAL-15K21746/
• Live imaging of cell-to-cell communication

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  MICHIYUKI MATSUDA

  From 29 Jun. 2015, To 31 Mar. 2020, Project Closed

  蛍光イメージング;蛍光顕微鏡;バイオセンサー;上皮細胞増殖因子;FRET;PKA;ERK;蛍光タンパク質;筋再生;イメージング;細胞生物学;再生;蛍光バイオセンサー;BRET;生体イメージング;発光イメージング;FRETバイオセンサー;分子プローブ;蛍光共鳴エネルギー移動;タンパク質リン酸化酵素;ＦＲＥＴバイオセンサー

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-15H05949/
• Resonance Biology for Innovative Bioimaging

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Institute of Physical and Chemical Research

  Atsushi Miyawaki

  From 29 Jun. 2015, To 31 Mar. 2020, Project Closed

  バイオイメージング;蛍光・発光タンパク質;蛍光色素;多光子顕微鏡;画像処理;蛍光・発光たんぱく質;細胞周期;顕微鏡技術

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-15H05947/
• In vivo imaging with FRET mice

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Michiyuki Matsuda

  From 01 Apr. 2015, To 31 Mar. 2019, Project Closed

  蛍光プローブ;組織形態マーカー;FRETバイオセンサー;機械学習;ROCK;蛍光イメージング;血管収縮;イメージング;透明化;FRET;トランスジェニックマウス;ERK MAPキナーゼ;細胞増殖;蛍光タンパク質;多光子顕微鏡

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H02397/
• Analysis of antitumor immunity induced by vaccinia virus with in vivo imaging

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Yoshiki Arakawa

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  悪性脳腫瘍;ワクシニアウイルス;生体イメージング;腫瘍免疫;免疫誘導;ウイルス治療;悪性グリオーマ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25462254/
• 生きたマウスでｐ５３からＡＴＭへのフィードバックループの動態を解析する

  Grant-in-Aid for JSPS Fellows

  Kyoto University

  松田 道行

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  p53;ATM;Cancer;FRET

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12F02415/
• Mutli-dimensional fluorescence live imaging of cellular function and molecular activity

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Kyoto University

  From 23 Jun. 2010, To 31 Mar. 2015

  https://kaken.nii.ac.jp/grant/KAKENHI-AREA-3204/
• Multidimendional FRET imaging of intracellular signal transduction

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  Michiyuki Matsuda

  From 01 Apr. 2010, To 31 Mar. 2016, Project Closed

  がん;二光子イメージング;フレットイメージング;蛍光タンパク質;バイオセンサー;FRETイメージング;FRET;蛍光共鳴エネルギー移動;生体イメージング;蛍光イメージング;神経発生;トランスジェニックマウス;Rac1;二光子顕微鏡;FRETバイオセンサー;Cdc42;MDCK細胞;脳腫瘍

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22113002/
• Multi-dimensional fluorescent live imaging of cellular functions and molecular activities

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  Matsuda MICHIYUKI

  From 01 Apr. 2010, To 31 Mar. 2016, Project Closed

  蛍光イメージング;蛍光顕微鏡;細胞生物学;蛍光タンパク質;蛍光プローブ;細胞生物;がん;蛍光生体イメージング;国際情報交換;国際研究者交流;ライブイメージング;ケミカルバイオロジー;生体イメージング;二光子顕微鏡;超解像度イメージング;緑色蛍光タンパク質;FRET

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-22113001/
• Spatio-temporal analysis of small GTPases involved in vesicular trafficking by fluorescence imaging

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Michiyuki MATSUDA

  From 01 Apr. 2007, To 31 Mar. 2011, Project Closed

  FRET;G蛋白;R-Ras;Rab5;Rac;Ral;アポトーシス;小胞輸送;バイオセンサー;Rac1;SH3BP1;Exocyst

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19209008/
• The core unit supporting research, communication, network and young scientists in the cancer research field

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Japanese Foundation For Cancer Research

  Takuro NAKAMURA

  From 01 Apr. 2005, To 31 Mar. 2010, Project Closed

  国際交流;若手支援;広報支援;青少年育成;広報活動

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17012024/
• Analysis on the spatio-temporal regulation of cellular oncogenesis

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University;Osaka University

  Michiyuki MATSUDA

  From 01 Apr. 2005, To 31 Mar. 2010, Project Closed

  がん;FRETバイオセンサー;蛍光イメージング;システム生物学;細胞増殖因子;がん遺伝子;上皮細胞増殖因子;Ras;MAPキナーゼ;Shoc2;FRET;細胞増殖;Rac1;イノシトールリン脂質;Asef;G蛋白;セリンスレオニンキナーゼ;Akt;PI3キナーゼ;Raf;transformation;signal;transduction;simulation;細胞増殖情報伝達系;シミュレーション;FRETプローブ;MEK;ERK

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17012014/
• New Frontiers of Cancer Sciences

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The University of Tokyo

  Tadatsugu TANIGUCHI

  From 01 Apr. 2005, To 31 Mar. 2010, Project Closed

  情報科学;がん免疫;構造生物学;発生と発がん;シグナル伝達

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17012004/
• Spatiotemporal regulation of Rho-family GTPases

  Grant-in-Aid for Scientific Research (B)

  Kyoto University;Osaka University

  Michiyuki MATSUDA

  From 01 Apr. 2004, To 31 Mar. 2007, Project Closed

  Rho;Rac;Cdc42;GFP;FRET;TC10;全反射蛍光顕微鏡;小胞輸送;FRETプローブ;上皮細胞増殖因子, Rho;Rac;Cdc42;GFP;FRET

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390078/
• Imaging of Ras-MAP kinase signal transduction cascade

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Osaka University

  Michiyuki MATSUDA

  From 01 Apr. 2004, To 31 Mar. 2005, Project Closed

  Ras;MAPK;Raf;シミュレーション, Ras;MAPK;Raf;Simulation

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16025201/
• Rasファミリー活性化因子の多様性からのゲノム進化の検討

  Grant-in-Aid for Scientific Research on Priority Areas (C)

  Biological Sciences

  Research Institute, International Medical Center of Japan

  望月 直樹

  From 01 Apr. 2000, To 31 Mar. 2001, Project Closed

  ゲノム;Ras;GDP;GTP交換因子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12206085/
• 低分子量G蛋白が細胞膜で情報を受け取るメカニズムの可視化

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Osaka University;Research Institute, International Medical Center of Japan

  松田 道行

  From 01 Apr. 1999, To 31 Mar. 2004, Project Closed

  Ras;FRET;Rapl;G蛋白;低分子量G蛋白;イメージング;Rap1;GFP

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11242209/
• Cross talk between oncogene and ant-oncogene via the Crk oncogene product

  Grant-in-Aid for Scientific Research (B)

  Osaka University;Research Institute, International Medical Center of Japan

  Michiyuki MATSUDA

  From 01 Apr. 1999, To 31 Mar. 2002, Project Closed

  Crk;FRET;蛍光共鳴エネルギー移動;細胞内情報伝達;アダプター蛋白質;Ras;Rapl;バイオテクノロジー;上皮細胞増殖因子;リン酸化;Rap2;グアニンヌクレオチド交換因子;GTP水解促進酵素;C3G;癌遺伝子;癌抑制遺伝子, Crk;FRET;fluorescent resonance energy transfer;signal transduction;adaptor protein;Ras;Rap1;biotechnology

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10470064/
• チロシンキナーゼおよびG蛋白によるHIV感染性の制御機構

  Grant-in-Aid for Scientific Research on Priority Areas

  Research Institute, International Medical Center of Japan

  松田 道行

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  HIV;Hck;Src;チロシンキナーゼ;Nef

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09258231/
• 低分子量G蛋白質による細胞の増殖、運動の制御機構

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Hiroshima University

  菊池 章

  From 01 Apr. 1997, To 31 Mar. 2000, Project Closed

  発がん;転移;低分子量G蛋白質;Ras;Rho;酵母;Ral;RasGRF1;GAP1m;CalDAGI;cAMP-GEF;PLD;細胞増殖;細胞運動

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09254103/
• Analysis of Oncogenesis by CRK, an Adaptor-type Oncogene

  Grant-in-Aid for Scientific Research (C)

  Research Institute, International Medical Center of Japan

  Micheyuki MATSUDA

  From 01 Apr. 1996, To 31 Mar. 1999, Project Closed

  CRK;C3G;Rap1;上皮細胞増殖因子;HIV;Hck;Src;チロシンキナーゼ;Nef;DOCK180;アダプター分子, CRK;C3G;Rap1;Epidermal growth factor

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08670266/
• CRK前癌遺伝子産物に結合する信号伝達下流因子の解析

  Grant-in-Aid for Encouragement of Young Scientists (A)

  国立予防衛生研究所

  松田 道行

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  CRK;チロシンキナーゼ;SH3領域

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07770174/
• 遺伝子導入動物を用いたRas活性化因子C3Gの解析

  Grant-in-Aid for Scientific Research on Priority Areas

  国立予防衛生研究所

  松田 道行

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  Ras;Rapl;CRK;チロシンキナーゼ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07272248/
• Ras蛋白を活性化するグアニンヌクレオチド交換因子の単離とその解析

  Grant-in-Aid for Encouragement of Young Scientists (A)

  国立予防衛生研究所

  松田 道行

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  CRK;Ras;Sos;C3G;チロシンキナーゼ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06770178/
• Phosphorylation of the Epstein-Barr virus BZLF1 immediate-early gene product (ZEBRA)

  Grant-in-Aid for General Scientific Research (B)

  National Institute of Health

  Takashi SAIRENJI

  From 01 Apr. 1994, To 31 Mar. 1996, Project Closed

  EBウイルス;EBV前初期遺伝子蛋白(ZEBRA);EBV活性化;EBV遺伝子発現;ZEBRA分子の多様性;IL-10;ZEBRAモノクローナル抗体;EBV遺伝子BCRF1蛋白;EBウイルス(EBV);EBV 前初期遺伝子蛋白(ZEBRA);ZEBRAのリン酸化, Epstein-Barr virus (EBV);BZLF1;BZLF1 promotor;EBV activation;EBV+T cell line;Second messengers;Chronic fatigue syndrome;Autibody response to human herpesviruses

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06454213/
• 増殖因子からの信号伝達を担うCRK蛋白の下流因子の同定

  Grant-in-Aid for Scientific Research on Priority Areas

  国立予防衛生研究所

  松田 道行

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  チロシンキナーゼ;Ras;CRK

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06281266/
• B細胞シグナル伝達と潜伏EBウイルスの活性化機構

  Grant-in-Aid for Scientific Research on Priority Areas

  国立予防衛生研究所

  西連寺 剛

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  EBウイルス(EBV);B細胞シグナル伝達;B細胞表面免疫グロブリン(sIg);BZLF1プロモーター;細胞内潜伏EBV;EBV潜伏感染T細胞株;vIL-10;EBV活性化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06280248/
• CRK遺伝子を介する細胞内信号伝達の機構

  Grant-in-Aid for Encouragement of Young Scientists (A)

  国立予防衛生研究所

  松田 道行

  From 01 Apr. 1993, To 31 Mar. 1994, Project Closed

  チロシンキナーゼ;CRK遺伝子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05770166/
• HIV感染の発症に関与するウイルス(特にヘルペス群)の役割について

  Grant-in-Aid for Scientific Research on Priority Areas

  国立予防衛生研究所

  倉田 毅

  From 01 Apr. 1992, To 31 Mar. 1993, Project Closed

  HIV感染;HHV6;EBV

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04269109/
• HIV感染の発症に関与するウイルス(特にヘルペス群)の役割について

  Grant-in-Aid for Scientific Research on Priority Areas

  国立予防衛生研究所

  倉田 毅

  From 01 Apr. 1991, To 31 Mar. 1992, Project Closed

  エイズ;PGL;EBV;HHV6;潜状感染;再活性化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03219109/
• HIV感染者の産生するJCウイルスの遺伝子構造とPML異常発生との相関

  Grant-in-Aid for Scientific Research on Priority Areas

  Tokyo Metropolitan Institute for Neuroscience

  保井 孝太郎

  From 01 Apr. 1991, To 31 Mar. 1992, Project Closed

  エイズ;PML;JCウィルス;進行性多巣性白質脳症;HIV;制御領域遺伝子;エンハンサ-;AIDS;調節領域遺伝子;遺伝子変異

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02235215/
• JCウイルスによる小脳髄芽腫の誘発と小脳分化の相関

  Grant-in-Aid for Cancer Research

  Tokyo Metropolitan Institute for Neuroscience

  保井 孝太郎

  From 01 Apr. 1987, To 31 Mar. 1988, Project Closed

  JCウイルス;小脳髄芽腫;神経細胞分化;promotorーenhancer;T抗原

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62015096/
• Advanced Bioimaging Support

  Grant-in-Aid for Transformative Research Areas (platforms for Advanced Technologies and Research Resources)

  National Institute for Physiological Sciences

  鍋倉 淳一

  From 01 Apr. 2022, To 31 Mar. 2028, Granted

  バイオイメージング;光学顕微鏡支援;電子顕微鏡支援;磁気共鳴画像支援;画像解析支援;トレーニング;科研費課題;Global BioImaging (GBI)

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H04926/

External funds: others

• 多次元定量イメージングに基づく数理モデルを用いた動的生命システムの革新的研究体系の開発・教育拠点

  文部科学省 創薬等ライフサイエンス研究支援基盤事業

  From 2012, To 2016

  松田　道行
• 多次元定量イメージングに基づく数理モデルを用いた動的生命システムの革新的研究体系の開発・教育拠点 （平成26年度分）

  文部科学省 創薬等ライフサイエンス研究支援基盤事業

  From 01 Apr. 2014, To 31 Mar. 2015

  松田　道行
• 多次元定量イメージングに基づく数理モデルを用いた動的生命システムの革新的研究体系の開発・教育拠点 （平成27年度分）

  文部科学省 医療研究開発推進事業費補助金

  From 01 Apr. 2015, To 31 Mar. 2016

  松田　道行
• 多次元定量イメージングに基づく数理モデルを用いた動的生命システムの革新的研究体系の開発・教育拠点 （平成28年度分）

  医療研究開発推進事業費補助金

  From 01 Apr. 2016, To 31 Mar. 2017

  松田　道行

Education

Teaching subject(s)

• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Course in Studies on Signal Transduction

  1029, Fall, Graduate School of Biostudies, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  General Pathology

  B014, Spring, Faculty of Medicine, 2.5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  General Pathology II

  E012, Spring, Graduate School of Medicine, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Experiments in Systemic Life Sciences

  5013, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Experiments in Systemic Life Sciences

  5013, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Systems Biology

  8213, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Systems Biology

  8213, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  General Pathology

  B014, Spring, Faculty of Medicine, 2.5
• From 01 Apr. 2022, To 31 Mar. 2023

  Cell, Developmental and Systems Biology (Seminar for Master Program)

  E054, Year-long, Graduate School of Medicine, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Biology and Life Science

  N484, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Experiments in Systemic Life Sciences

  5013, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  General Pathology

  L150, Spring, Faculty of Medicine, 0
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Experiments in Systemic Life Sciences

  5013, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Course in Studies on Signal Transduction

  1029, Fall, Graduate School of Biostudies, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Cell, Developmental and Systems Biologys (Practice for Master Program)

  E055, Year-long, Graduate School of Medicine, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  General Pathology II

  E012, Spring, Graduate School of Medicine, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  General Pathology

  M008, Spring, Graduate School of Medicine, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Cell, Developmental and Systems Biology (Practice)

  P030, Year-long, Graduate School of Medicine, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Cell, Developmental and Systems Biology (Seminar)

  P029, Year-long, Graduate School of Medicine, 4
• General Pathology
• From Apr. 2011, To Mar. 2012

  病理学　II

  Spring, 医学研究科
• From Apr. 2011, To Mar. 2012

  病理学

  Spring, 医学研究科
• From Apr. 2011, To Mar. 2012

  発生・細胞生物学（演習）

  Year-long, 医学研究科
• From Apr. 2011, To Mar. 2012

  発生・細胞生物学（実習）

  Year-long, 医学研究科
• From Apr. 2011, To Mar. 2012

  Perspectives on Life Science A

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Perspectives on Life Science A

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  General Pathology

  Year-long, 医学研究科
• From Apr. 2012, To Mar. 2013

  General Pathology II

  Spring, 医学研究科
• From Apr. 2012, To Mar. 2013

  Cell and Developmental Biology(Practice)

  Year-long, 医学研究科
• From Apr. 2012, To Mar. 2013

  Cell and Developmental Biology(Seminar)

  Year-long, 医学研究科
• From Apr. 2013, To Mar. 2014

  General Pathology

  Spring, 医学部
• From Apr. 2013, To Mar. 2014

  General Pathology II

  Spring, 医学研究科
• From Apr. 2013, To Mar. 2014

  General Pathology

  Spring, 医学研究科
• From Apr. 2013, To Mar. 2014

  発生・細胞生物学・システム生物学（演習）

  Year-long, 医学研究科
• From Apr. 2013, To Mar. 2014

  発生・細胞生物学・システム生物学（実習）

  Year-long, 医学研究科
• From Apr. 2013, To Mar. 2014

  Advanced Course in Studies on Signal Transduction

  Fall, 生命科学研究科
• From Apr. 2013, To Mar. 2014

  Study of Life Science I

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  General Pathology

  Spring, 医学部
• From Apr. 2014, To Mar. 2015

  General Pathology II

  Spring, 医学研究科
• From Apr. 2014, To Mar. 2015

  General Pathology

  Spring, 医学研究科
• From Apr. 2014, To Mar. 2015

  Cell, Developmental and Systems Biology (Seminar)

  Year-long, 医学研究科
• From Apr. 2014, To Mar. 2015

  Cell, Developmental and Systems Biology (Practice)

  Year-long, 医学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Course in Studies on Signal Transduction

  Fall, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Experimental Course and Seminar l

  Year-long, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Experimental Course and Seminar 2

  Year-long, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Experimental Course and Seminar 2

  Year-long, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Experiments in Systemic Life Sciences

  Year-long, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Molecular and Cellular Biology

  Fall, 総合生存学館
• From Apr. 2014, To Mar. 2015

  Study of Life Science I

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  General Pathology

  Spring, 医学部
• From Apr. 2015, To Mar. 2016

  Advanced Course in Studies on Signal Transduction

  Spring, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Molecular and Cellular Biology

  Fall, 総合生存学館
• From Apr. 2015, To Mar. 2016

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Study of Life Science I

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  General Pathology

  Spring, 医学研究科
• From Apr. 2015, To Mar. 2016

  General Pathology II

  Spring, 医学研究科
• From Apr. 2015, To Mar. 2016

  Cell, Developmental and Systems Biology (Practice)

  Year-long, 医学研究科
• From Apr. 2015, To Mar. 2016

  Cell, Developmental and Systems Biology (Seminar)

  Year-long, 医学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  General Pathology

  Spring, 医学部
• From Apr. 2016, To Mar. 2017

  Advanced Course in Studies on Signal Transduction

  Spring, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Molecular and Cellular Biology

  Fall, 総合生存学館
• From Apr. 2016, To Mar. 2017

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Introduction to Biology and Life Science

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  General Pathology

  Spring, 医学研究科
• From Apr. 2016, To Mar. 2017

  General Pathology II

  Spring, 医学研究科
• From Apr. 2016, To Mar. 2017

  Cell, Developmental and Systems Biology (Practice)

  Year-long, 医学研究科
• From Apr. 2016, To Mar. 2017

  Cell, Developmental and Systems Biology (Seminar)

  Year-long, 医学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  General Pathology

  Spring, 医学部
• From Apr. 2017, To Mar. 2018

  Advanced Course in Studies on Signal Transduction

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Molecular and Cellular Biology

  Fall, 総合生存学館
• From Apr. 2017, To Mar. 2018

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  General Pathology

  Spring, 医学研究科
• From Apr. 2017, To Mar. 2018

  General Pathology II

  Spring, 医学研究科
• From Apr. 2017, To Mar. 2018

  Cell, Developmental and Systems Biology (Practice)

  Year-long, 医学研究科
• From Apr. 2017, To Mar. 2018

  Cell, Developmental and Systems Biology (Seminar)

  Year-long, 医学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  General Pathology

  Spring, 医学部
• From Apr. 2018, To Mar. 2019

  General Pathology

  Spring, 医学部
• From Apr. 2018, To Mar. 2019

  Advanced Course in Studies on Signal Transduction

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar A

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar A

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar B

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar B

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar C

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar C

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar D

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar D

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Introduction to Biology and Life Science

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  General Pathology

  Spring, 医学研究科
• From Apr. 2018, To Mar. 2019

  General Pathology II

  Spring, 医学研究科
• From Apr. 2018, To Mar. 2019

  Cell, Developmental and Systems Biology (Practice)

  Year-long, 医学研究科
• From Apr. 2018, To Mar. 2019

  Cell, Developmental and Systems Biology (Seminar)

  Year-long, 医学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  General Pathology

  Spring, 医学部
• From Apr. 2019, To Mar. 2020

  General Pathology

  Spring, 医学部
• From Apr. 2019, To Mar. 2020

  Advanced Course in Studies on Signal Transduction

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar A

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar A

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar B

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar B

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar C

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar C

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar D

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar D

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  General Pathology

  Spring, 医学研究科
• From Apr. 2019, To Mar. 2020

  General Pathology II

  Spring, 医学研究科
• From Apr. 2019, To Mar. 2020

  Cell, Developmental and Systems Biologys (Practice for Master Program)

  Year-long, 医学研究科
• From Apr. 2019, To Mar. 2020

  Cell, Developmental and Systems Biology (Seminar for Master Program)

  Year-long, 医学研究科
• From Apr. 2019, To Mar. 2020

  Cell, Developmental and Systems Biology (Practice)

  Year-long, 医学研究科
• From Apr. 2019, To Mar. 2020

  Cell, Developmental and Systems Biology (Seminar)

  Year-long, 医学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  General Pathology

  Spring, 医学部
• From Apr. 2020, To Mar. 2021

  General Pathology

  Spring, 医学部
• From Apr. 2020, To Mar. 2021

  Advanced Course in Studies on Signal Transduction

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Introduction to Biology and Life Science

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  General Pathology

  Spring, 医学研究科
• From Apr. 2020, To Mar. 2021

  General Pathology II

  Spring, 医学研究科
• From Apr. 2020, To Mar. 2021

  Cell, Developmental and Systems Biologys (Practice for Master Program)

  Year-long, 医学研究科
• From Apr. 2020, To Mar. 2021

  Cell, Developmental and Systems Biology (Seminar for Master Program)

  Year-long, 医学研究科
• From Apr. 2020, To Mar. 2021

  Cell, Developmental and Systems Biology (Practice)

  Year-long, 医学研究科
• From Apr. 2020, To Mar. 2021

  Cell, Developmental and Systems Biology (Seminar)

  Year-long, 医学研究科
• From Apr. 2021, To Mar. 2022

  General Pathology

  Spring, 医学部
• From Apr. 2021, To Mar. 2022

  General Pathology

  Spring, 医学部
• From Apr. 2021, To Mar. 2022

  Advanced Course in Studies on Signal Transduction

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Experiments in Integrated Life Sciences

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Experiments in Integrated Life Sciences

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  General Pathology

  Spring, 医学研究科
• From Apr. 2021, To Mar. 2022

  General Pathology II

  Spring, 医学研究科
• From Apr. 2021, To Mar. 2022

  Cell, Developmental and Systems Biologys (Practice for Master Program)

  Year-long, 医学研究科
• From Apr. 2021, To Mar. 2022

  Cell, Developmental and Systems Biology (Seminar for Master Program)

  Year-long, 医学研究科
• From Apr. 2021, To Mar. 2022

  Cell, Developmental and Systems Biology (Practice)

  Year-long, 医学研究科
• From Apr. 2021, To Mar. 2022

  Cell, Developmental and Systems Biology (Seminar)

  Year-long, 医学研究科