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Fukai, Shuya

Graduate School of Science, Division of Chemistry Professor

Fukai, Shuya
list
    Last Updated :2022/08/06

    Basic Information

    Faculty

    • 理学部

    Academic Degree

    • Master of Science(The University of Tokyo)
    • Doctor of Science(The University of Tokyo)

    Research History

    • From Mar. 2020, To Present
      Kyoto University, Department of Chemistry, Graduate School of Science, Professor
    • From Apr. 2018, To Feb. 2020
      The University of Tokyo, Institute for Quantitative Biosciences, Associate Professor
    • From Dec. 2016, To Mar. 2018
      The University of Tokyo, Institute of Molecular and Cellular Biosciences, 准教授
    • From May 2007, To Nov. 2016
      The University of Tokyo, Organization for Synchrotron Radiation Research, 准教授
    • From Apr. 2006, To May 2007
      Tokyo Institute of Technology, Center for Biological Resources and Informatics, 助教授(2007年4月より准教授に名称変更)
    • From Jun. 2003, To Mar. 2006
      Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Department of Biological Information, 助手
    • From Apr. 2002, To Jul. 2003
      Stanford University School of Medicine, Department of Molecular and Cellular Physiology, JSPS Postdoctoral Fellow for Research Abroad

    ID,URL

    researchmap URL

    list
      Last Updated :2022/08/06

      Research

      Research Interests

      • 構造生物化学
      • Structural biological chemistry

      Research Areas

      • Life sciences, Structural biochemistry

      Papers

      • S06A2 Structural insights into the chemical modification in non-coding RNAs(Structural Biology of ncRNA Processing and Function)
        Numata Tomoyuki; Nakanishi Kotaro; Suzuki Yoko; Noma Akiko; Ikeuchi Yoshiho; Suzuki Tsutomu; Fukai Shuya; Ishitani Ryuichiro; Nureki Osamu
        Seibutsu Butsuri, 2007
      • 2P027 The crystal structure analysis of Aquifex aeolicus methionl-tRNA synethetase(29. Protein structure and dynamics (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
        Nakanishi Kotaro; Komoto Yasuhiro; Fukai Shuya; Nureki Osamu
        Seibutsu Butsuri, 2006
      • 1P014 Snapshots of tRNA sulfuration via an adenylated intermediate(1. Protein structure and dynamics (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
        Numata Tomoyuki; Ikeuchi Yoshiho; Fukai Shuya; Suzuki Tsutomu; Nureki Osamu
        Seibutsu Butsuri, 2006
      • 1P358 Structural analysis of the Mammalian Exocyst Complex(13. Membrane transport,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
        Fukai Shuya; Maruyama Yusuke; Shirakawa Ryutaro; Horiuchi Hisanori; Sato Chikara; Nureki Osamu
        Seibutsu Butsuri, 2006
      • 1P357 Crystal structure of yeast Sec2p, a guanine nucleotide exchange factor for yeast Rab GTPase, Sec4p(13. Membrane transport,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
        Sato Yusuke; Shirakawa Ryutaro; Horiuchi Hisanori; Dohmae Naoshi; Fukai Shuya; Nureki Osamu
        Seibutsu Butsuri, 2006
      • 1P356 Crystallization and X-ray diffraction of SecYE translocon from Thermus thermophilus with a Fab fragment(13. Membrane transport,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
        Tsukazaki Tomoya; Mori Hiroyuki; Ishitani Ryuichiro; Fukai Shuya; Perederina Anna; Vassylyev Dmitry G.; Ito Koreaki; Nureki Osamu
        Seibutsu Butsuri, 2006
      • 2P168 Structural Basis of RNA-Dependent Recruitment of Glutamine to the Genetic Code(35. RNA world,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
        Oshikane Hiroyuki; Sheppard Kelly; Nakamura Yuko; Fukai Shuya; Feng Liang; Numata Tomoyuki; Ishitani Ryuichiro; Soll Dieter; Nureki Osamu
        Seibutsu Butsuri, 2006
      • 2P151 Crystallization and preliminary X-ray analysis of the bacterial membrane transporters(34. Membrane protein,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
        Hattori Motoyuki; Tanaka Yoshiki; Fukai Shuya; Ishitani Ryuichiro; Nureki Osamu
        Seibutsu Butsuri, 2006
      • 1P304 Crystal structure of Formin Homology 2 domain of human DAAM1(10. Cytoskeleton,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
        Yamashita Masami; Higashi Tomohito; Sato Yusuke; Shirakawa Ryutaro; Kita Toru; Horiuchi Hisanori; Fukai Shuya; Nureki Osamu
        Seibutsu Butsuri, 2006
      • 3P219 Preparation of the mammalian Exocyst complex for the three-dimensional structure determination
        Fukai S.; Shirakawa R.; Horiuchi H.; Mio K.; Maruyama Y.; Sato C.; Nureki O.
        Seibutsu Butsuri, 2005
      • 3P014 Crystallographic study of yeast Sec2, a guanine nucleotide exchange factor (GEF) for yeast Rab GTPase, Sec4
        Sato Y.; Fukai S.; Nureki O.
        Seibutsu Butsuri, 2005
      • 1P125 Structural basis for anticodon recognition by methionyl-tRNA synthetase
        Nakanishi K.; Ogiso Y.; Nakama T.; Fukai S.; Nureki O.
        Seibutsu Butsuri, 2005
      • Structural change of tRNA (Gm18) methyltransferase by binding of methyl donor analogues.
        Watanabe K; Nureki O; Fukai S; Endo Y; Hori H
        Nucleic acids symposium series (2004), 2005, Peer-reviewed
      • Structural Basis for Specific Recognition and Cleavage of Polyubiquitin Chains
        FUKAI Shuya; SATO Yusuke
        X-RAYS, 28 Feb. 2010
      • Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains (Nature (2008) 455, (358-362))
        Y. Sato; A. Yoshikawa; A. Yamagata; H. Mimura; M. Yamashita; K. Ookata; O. Nureki; K. Iwai; M. Komada; S. Fukai
        Nature, 2008, Peer-reviewed
      • 14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice
        Norihiko Yokoi; Yuko Fukata; Kei Okatsu; Atsushi Yamagata; Yan Liu; Makoto Sanbo; Yuri Miyazaki; Teppei Goto; Manabu Abe; Hidetoshi Kassai; Kenji Sakimura; Dies Meijer; Masumi Hirabayashi; Shuya Fukai; Masaki Fukata
        Cell Reports, Dec. 2021, Peer-reviewed
      • Structural basis for specific recognition of K6-linked polyubiquitin chains by the TAB2 NZF domain
        Yanjun Li; Kei Okatsu; Shuya Fukai; Yusuke Sato
        Biophysical Journal, Jul. 2021, Peer-reviewed
      • Canonical versus non-canonical transsynaptic signaling of neuroligin 3 tunes development of sociality in mice
        Tomoyuki Yoshida; Atsushi Yamagata; Ayako Imai; Juhyon Kim; Hironori Izumi; Shogo Nakashima; Tomoko Shiroshima; Asami Maeda; Shiho Iwasawa-Okamoto; Kenji Azechi; Fumina Osaka; Takashi Saitoh; Katsumi Maenaka; Takashi Shimada; Yuko Fukata; Masaki Fukata; Jumpei Matsumoto; Hisao Nishijo; Keizo Takao; Shinji Tanaka; Shigeo Okabe; Katsuhiko Tabuchi; Takeshi Uemura; Masayoshi Mishina; Hisashi Mori; Shuya Fukai
        Nature Communications, Mar. 2021, Peer-reviewed, Corresponding author
      • LGI1–ADAM22–MAGUK configures transsynaptic nanoalignment for synaptic transmission and epilepsy prevention
        Yuko Fukata; Xiumin Chen; Satomi Chiken; Yoko Hirano; Atsushi Yamagata; Hiroki Inahashi; Makoto Sanbo; Hiromi Sano; Teppei Goto; Masumi Hirabayashi; Hans-Christian Kornau; Harald Prüss; Atsushi Nambu; Shuya Fukai; Roger A. Nicoll; Masaki Fukata
        Proceedings of the National Academy of Sciences, 19 Jan. 2021, Peer-reviewed
      • A Human DUB Protein Array for Clarification of Linkage Specificity of Polyubiquitin Chain and Application to Evaluation of Its Inhibitors
        Hirotaka Takahashi; Satoshi Yamanaka; Shohei Kuwada; Kana Higaki; Kohki Kido; Yusuke Sato; Shuya Fukai; Fuminori Tokunaga; Tatsuya Sawasaki
        Biomedicines, 04 Jun. 2020, Peer-reviewed, Invited
      • Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses.
        Oikawa D; Sato Y; Ohtake F; Komakura K; Hanada K; Sugawara K; Terawaki S; Mizukami Y; Phuong HT; Iio K; Obika S; Fukushi M; Irie T; Tsuruta D; Sakamoto S; Tanaka K; Saeki Y; Fukai S; Tokunaga F.
        Communications Biology, Apr. 2020, Peer-reviewed
      • Subquinocin, a small molecule inhibitor of CYLD and USP-family deubiquitinating enzymes, promotes NF-κB signaling.
        Satoshi Yamanaka; Yusuke Sato; Daisuke Oikawa; Eiji Goto; Shuya Fukai; Fuminori Tokunaga; Hirotaka Takahashi; Tatsuya Sawasaki
        Biochemical and biophysical research communications, 26 Mar. 2020, Peer-reviewed
      • A SNARE geranylgeranyltransferase essential for the organization of the Golgi apparatus.
        Ryutaro Shirakawa; Sakurako Goto-Ito; Kota Goto; Shonosuke Wakayama; Haremaru Kubo; Natsumi Sakata; Duc Anh Trinh; Atsushi Yamagata; Yusuke Sato; Hiroshi Masumoto; Jinglei Cheng; Toyoshi Fujimoto; Shuya Fukai; Hisanori Horiuchi
        The EMBO journal, 03 Mar. 2020, Peer-reviewed, Corresponding author
      • Structural insights into selective interaction between type IIa receptor protein tyrosine phosphatases and Liprin-α.
        Maiko Wakita; Atsushi Yamagata; Tomoko Shiroshima; Hironori Izumi; Asami Maeda; Mizuki Sendo; Ayako Imai; Keiko Kubota; Sakurako Goto-Ito; Yusuke Sato; Hisashi Mori; Tomoyuki Yoshida; Shuya Fukai
        Nature communications, 31 Jan. 2020, Peer-reviewed, Last author, Corresponding author
      • Structural insights into ubiquitin recognition and Ufd1 interaction of Npl4.
        Yusuke Sato; Hikaru Tsuchiya; Atsushi Yamagata; Kei Okatsu; Keiji Tanaka; Yasushi Saeki; Shuya Fukai
        Nature communications, 13 Dec. 2019, Peer-reviewed
      • Structural basis of ubiquitin recognition by the winged-helix domain of Cockayne syndrome group B protein.
        Tomio S Takahashi; Yusuke Sato; Atsushi Yamagata; Sakurako Goto-Ito; Masafumi Saijo; Shuya Fukai
        Nucleic acids research, 23 Apr. 2019, Peer-reviewed
      • Structural basis of guanine nucleotide exchange for Rab11 by SH3BP5.
        Sakurako Goto-Ito; Nobukatsu Morooka; Atsushi Yamagata; Yusuke Sato; Ken Sato; Shuya Fukai
        Life science alliance, Apr. 2019, Peer-reviewed
      • Crystal structure of the central and the C-terminal RNase domains of colicin D implicated its translocation pathway through inner membrane of target cell.
        Chang JW; Sato Y; Ogawa T; Arakawa T; Fukai S; Fushinobu S; Masaki H
        Journal of biochemistry, Nov. 2018, Peer-reviewed
      • Structural insights into modulation and selectivity of transsynaptic neurexin-LRRTM interaction.
        Atsushi Yamagata; Sakurako Goto-Ito; Yusuke Sato; Tomoko Shiroshima; Asami Maeda; Masahiko Watanabe; Takashi Saitoh; Katsumi Maenaka; Tohru Terada; Tomoyuki Yoshida; Takeshi Uemura; Shuya Fukai
        Nature communications, 27 Sep. 2018, Peer-reviewed
      • Structural insights into ubiquitin phosphorylation by PINK1.
        Okatsu K; Sato Y; Yamano K; Matsuda N; Negishi L; Takahashi A; Yamagata A; Goto-Ito S; Mishima M; Ito Y; Oka T; Tanaka K; Fukai S
        Scientific reports, Jul. 2018, Peer-reviewed
      • Structural basis of epilepsy-related ligand–receptor complex LGI1–ADAM22
        Atsushi Yamagata; Yuri Miyazaki; Norihiko Yokoi; Hideki Shigematsu; Yusuke Sato; Sakurako Goto-Ito; Asami Maeda; Teppei Goto; Makoto Sanbo; Masumi Hirabayashi; Mikako Shirouzu; Yuko Fukata; Masaki Fukata; Shuya Fukai
        Nature Communications, 18 Apr. 2018, Peer-reviewed, Last author, Corresponding author
      • Structural basis of trans-synaptic interactions between PTPδ and SALMs for inducing synapse formation
        Sakurako Goto-Ito; Atsushi Yamagata; Yusuke Sato; Takeshi Uemura; Tomoko Shiroshima; Asami Maeda; Ayako Imai; Hisashi Mori; Tomoyuki Yoshida; Shuya Fukai
        Nature Communications, 18 Jan. 2018, Peer-reviewed
      • Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168
        Tomio S. Takahashi; Yoshihiro Hirade; Aya Toma; Yusuke Sato; Atsushi Yamagata; Sakurako Goto-Ito; Akiko Tomita; Shinichiro Nakada; Shuya Fukai
        Nature Communications, 12 Jan. 2018, Peer-reviewed
      • Structural basis for specific cleavage of Lys6-linked polyubiquitin chains by USP30.
        Yusuke Sato; Kei Okatsu; Yasushi Saeki; Koji Yamano; Noriyuki Matsuda; Ai Kaiho; Atsushi Yamagata; Sakurako Goto-Ito; Minoru Ishikawa; Yuichi Hashimoto; Keiji Tanaka; Shuya Fukai
        Nature structural & molecular biology, Nov. 2017, Peer-reviewed
      • Structural basis for CRMP2-induced axonal microtubule formation
        Shinsuke Niwa; Fumio Nakamura; Yuri Tomabechi; Mari Aoki; Hideki Shigematsu; Takashi Matsumoto; Atsushi Yamagata; Shuya Fukai; Nobutaka Hirokawa; Yoshio Goshima; Mikako Shirouzu; Ryo Nitta
        Scientific Reports, Sep. 2017, Peer-reviewed
      • Structural basis of the interaction between Topoisomerase III beta and the TDRD3 auxiliary factor
        Sakurako Goto-Ito; Atsushi Yamagata; Tomio S. Takahashi; Yusuke Sato; Shuya Fukai
        SCIENTIFIC REPORTS, Feb. 2017, Peer-reviewed
      • Crystal structure of Sec10, a subunit of the exocyst complex
        Jianxing Chen; Atsushi Yamagata; Keiko Kubota; Yusuke Sato; Sakurako Goto-Ito; Shuya Fukai
        Scientific Reports, Jan. 2017, Peer-reviewed
      • Distinct Roles for the N- and C-terminal Regions of M-Sec in Plasma Membrane Deformation during Tunneling Nanotube Formation
        Shunsuke Kimura; Masami Yamashita; Megumi Yamakami-Kimura; Yusuke Sato; Atsushi Yamagata; Yoshihiro Kobashigawa; Fuyuhiko Inagaki; Takako Amada; Koji Hase; Toshihiko Iwanaga; Hiroshi Ohno; Shuya Fukai
        Scientific Reports, Sep. 2016, Peer-reviewed
      • Structure of Slitrk2-PTP delta complex reveals mechanisms for splicing-dependent trans-synaptic adhesion
        Atsushi Yamagata; Yusuke Sato; Sakurako Goto-Ito; Takeshi Uemura; Asami Maeda; Tomoko Shiroshima; Tomoyuki Yoshida; Shuya Fukai
        Scientific Reports, May 2015, Peer-reviewed
      • Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation
        Atsushi Yamagata; Tomoyuki Yoshida; Yusuke Sato; Sakurako Goto-Ito; Takeshi Uemura; Asami Maeda; Tomoko Shiroshima; Shiho Iwasawa-Okamoto; Hisashi Mori; Masayoshi Mishina; Shuya Fukai
        NATURE COMMUNICATIONS, Apr. 2015, Peer-reviewed
      • Structures of CYLD USP with Met1-or Lys63-linked diubiquitin reveal mechanisms for dual specificity
        Yusuke Sato; Eiji Goto; Yuri Shibata; Yuji Kubota; Atsushi Yamagata; Sakurako Goto-Ito; Keiko Kubota; Jun-ichiro Inoue; Mutsuhiro Takekawa; Fuminori Tokunaga; Shuya Fukai
        NATURE STRUCTURAL & MOLECULAR BIOLOGY, Mar. 2015, Peer-reviewed
      • Structural Basis for Ubiquitin Recognition by Ubiquitin-Binding Zinc Finger of FAAP20
        Aya Toma; Tomio S. Takahashi; Yusuke Sato; Atsushi Yamagata; Sakurako Goto-Ito; Shinichiro Nakada; Atsuhiko Fukuto; Yasunori Horikoshi; Satoshi Tashiro; Shuya Fukai
        PLOS ONE, Mar. 2015, Peer-reviewed
      • Switching and emergence of CTL epitopes in HIV-1 infection
        Chungyong Han; Ai Kawana-Tachikawa; Akihisa Shimizu; Dayong Zhu; Hitomi Nakamura; Eisuke Adachi; Tadashi Kikuchi; Michiko Koga; Tomohiko Koibuchi; George F. Gao; Yusuke Sato; Atsushi Yamagata; Eric Martin; Shuya Fukai; Zabrina L. Brumme; Aikichi Iwamoto
        RETROVIROLOGY, May 2014, Peer-reviewed
      • Core Structures of Ubiquitin Dictate Its Dynamics and Function
        Shuya Fukai
        JOURNAL OF MOLECULAR BIOLOGY, Apr. 2014, Peer-reviewed
      • Structure of TCR and antigen complexes at an immunodominant CTL epitope in HIV-1 infection
        Akihisa Shimizu; Ai Kawana-Tachikawa; Atsushi Yamagata; Chungyong Han; Dayong Zhu; Yusuke Sato; Hitomi Nakamura; Tomohiko Koibuchi; Jonathan Carlson; Eric Martin; Chanson J. Brumme; Yi Shi; George F. Gao; Zabrina L. Brumme; Shuya Fukai; Aikichi Iwamoto
        SCIENTIFIC REPORTS, Nov. 2013, Peer-reviewed
      • Get1 Stabilizes an Open Dimer Conformation of Get3 ATPase by Binding Two Distinct Interfaces
        Keiko Kubota; Atsushi Yamagata; Yusuke Sato; Sakurako Goto-Ito; Shuya Fukai
        JOURNAL OF MOLECULAR BIOLOGY, Sep. 2012, Peer-reviewed
      • Molecular Basis of Lys-63-linked Polyubiquitination Inhibition by the Interaction between Human Deubiquitinating Enzyme OTUB1 and Ubiquitin-conjugating Enzyme UBC13
        Yusuke Sato; Atsushi Yamagata; Sakurako Goto-Ito; Keiko Kubota; Rikako Miyamoto; Shinichiro Nakada; Shuya Fukai
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2012, Peer-reviewed
      • Specific recognition of linear ubiquitin chains by the Npl4 zinc finger (NZF) domain of the HOIL-1L subunit of the linear ubiquitin chain assembly complex
        Yusuke Sato; Hiroaki Fujita; Azusa Yoshikawa; Masami Yamashita; Atsushi Yamagata; Stephen E. Kaiser; Kazuhiro Iwai; Shuya Fukai
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 2011, Peer-reviewed
      • Structure and function of a membrane component SecDF that enhances protein export
        Tomoya Tsukazaki; Hiroyuki Mori; Yuka Echizen; Ryuichiro Ishitani; Shuya Fukai; Takeshi Tanaka; Anna Perederina; Dmitry G. Vassylyev; Toshiyuki Kohno; Andres D. Maturana; Koreaki Ito; Osamu Nureki
        NATURE, Jun. 2011, Peer-reviewed
      • Structural basis for the Rho- and phosphoinositide-dependent localization of the exocyst subunit Sec3
        Masami Yamashita; Kazuo Kurokawa; Yusuke Sato; Atsushi Yamagata; Hisatoshi Mimura; Azusa Yoshikawa; Ken Sato; Akihiko Nakano; Shuya Fukai
        NATURE STRUCTURAL & MOLECULAR BIOLOGY, Feb. 2010, Peer-reviewed
      • Structural insight into the membrane insertion of tail-anchored proteins by Get3
        Atsushi Yamagata; Hisatoshi Mimura; Yusuke Sato; Masami Yamashita; Azusa Yoshikawa; Shuya Fukai
        GENES TO CELLS, Jan. 2010, Peer-reviewed
      • Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3
        Yusuke Sato; Azusa Yoshikawa; Masami Yamashita; Atsushi Yamagata; Shuya Fukai
        EMBO JOURNAL, Dec. 2009, Peer-reviewed
      • Mechanism for the definition of elongation and termination by the class II CCA-adding enzyme
        Yukimatsu Toh; Daijiro Takeshita; Tomoyuki Numata; Shuya Fukai; Osamu Nureki; Kozo Tomita
        EMBO JOURNAL, Nov. 2009, Peer-reviewed
      • Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin
        Azusa Yoshikawa; Yusuke Sato; Masami Yamashita; Hisatoshi Mimura; Atsushi Yamagata; Shuya Fukai
        FEBS LETTERS, Oct. 2009, Peer-reviewed
      • Tuberous Sclerosis Tumor Suppressor Complex-like Complexes Act as GTPase-activating Proteins for Ral GTPases
        Ryutaro Shirakawa; Shuya Fukai; Mitsunori Kawato; Tomohito Higashi; Hirokazu Kondo; Tomoyuki Ikeda; Ei Nakayama; Katsuya Okawa; Osamu Nureki; Takeshi Kimura; Toru Kita; Hisanori Horiuchi
        JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2009, Peer-reviewed
      • Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80
        Yusuke Sato; Azusa Yoshikawa; Hisatoshi Mimura; Masami Yamashita; Atsushi Yamagata; Shuya Fukai
        EMBO JOURNAL, Aug. 2009, Peer-reviewed
      • Crystallization and preliminary X-ray diffraction analysis of GCIP/HHM transcriptional regulator
        Azusa Seto; Hiroaki Ikushima; Toshiyasu Suzuki; Yusuke Sato; Shuya Fukai; Keiko Yuki; Keiji Miyazawa; Kohei Miyazono; Ryuichiro Ishitani; Osamu Nureki
        ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Jan. 2009, Peer-reviewed
      • Conformational transition of Sec machinery inferred from bacterial SecYE structures
        Tomoya Tsukazaki; Hiroyuki Mori; Shuya Fukai; Ryuichiro Ishitani; Takaharu Mori; Naoshi Dohmae; Anna Perederina; Yuji Sugita; Dmitry G. Vassylyev; Koreaki Ito; Osamu Nureki
        NATURE, Oct. 2008, Peer-reviewed
      • Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains
        Yusuke Sato; Azusa Yoshikawa; Atsushi Yamagata; Hisatoshi Mimura; Masami Yamashita; Kayoko Ookata; Osamu Nureki; Kazuhiro Iwai; Masayuki Komada; Shuya Fukai
        NATURE, Sep. 2008, Peer-reviewed
      • Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and daam1, in platelets
        Tomohito Higashi; Tomoyuki Ikeda; Ryutaro Shirakawa; Hirokazu Kondo; Mitsunori Kawato; Masahito Horiguchi; Tomohiko Okuda; Katsuya Okawa; Shuya Fukai; Osamu Nureki; Toru Kita; Hisanori Horiuchi
        JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2008, Peer-reviewed
      • Regulation of platelet dense granule secretion by the Ral GTPase-exocyst pathway
        Mitsunori Kawato; Ryutaro Shirakawa; Hirokazu Kondo; Tomohito Higashi; Tomoyuki Ikeda; Katsuya Okawa; Shuya Fukai; Osamu Nureki; Toru Kita; Hisanori Horiuchi
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2008, Peer-reviewed
      • Crystal structure of human DAAM1 formin homology 2 domain
        Masami Yamashita; Tomohito Higashi; Shiro Suetsugu; Yusuke Sato; Tomoyuki Ikeda; Ryutaro Shirakawa; Toru Kita; Tadaomi Takenawa; Hisanori Horiuchi; Shuya Fukai; Osamu Nureki
        GENES TO CELLS, Nov. 2007, Peer-reviewed
      • Crystallization and preliminary X-ray diffraction analysis of the cytosolic domain of the Mg2+ transporter MgtE
        Yoshiki Tanaka; Motoyuki Hattori; Shuya Fukai; Ryuichiro Ishitania; Osamu Nureki
        ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Aug. 2007, Peer-reviewed
      • Crystallization and preliminary X-ray diffraction analysis of the full-length Mg2+ transporter MgtE
        Motoyuki Hattori; Yoshiki Tanaka; Shuya Fukai; Ryuichiro Ishitani; Osamu Nureki
        ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Aug. 2007, Peer-reviewed
      • Crystal structure of the MgtE Mg2+ transporter
        Motoyuki Hattori; Yoshiki Tanaka; Shuya Fukai; Ryuichiro Ishitani; Osamu Nureki
        NATURE, Aug. 2007, Peer-reviewed
      • Crystallization and crystallographic analysis of yeast Sec2p, a guanine nucleotide-exchange factor for the yeast Rab GTPase Sec4p
        Yusuke Sato; Shuya Fukai; Osamu Nureki
        ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Jul. 2007, Peer-reviewed
      • Crystal structure of the Sec4p-Sec2p complex in the nucleotide exchanging intermediate state
        Yusuke Sato; Shuya Fukai; Ryuichiro Ishitani; Osamu Nureki
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2007, Peer-reviewed
      • Asymmetric coiled-coil structure with guanine nucleotide exchange activity
        Yusuke Sato; Ryutaro Shirakawa; Hisanori Horiuchi; Naoshi Dohmae; Shuya Fukai; Osamu Nureki
        STRUCTURE, Feb. 2007, Peer-reviewed
      • Crystal structures of leucyl/phenylalanyl-tRNA-protein transferase and its complex with an aminoacyl-tRNA analog
        Kyoko Suto; Yoshihiro Shimizu; Kazunori Watanabe; Takuya Ueda; Shuya Fukai; Osamu Nureki; Kozo Tomita
        EMBO JOURNAL, Dec. 2006, Peer-reviewed
      • Functional categorization of the conserved basic amino acid residues in TrmH (tRNA (Gm18) methyltansferase) enzymes
        Kazunori Watanabe; Osamu Nureki; Shuya Fukai; Yaeta Endo; Hiroyuki Hori
        JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2006, Peer-reviewed
      • Complete crystallographic analysis of the dynamics of CCA sequence addition
        Kozo Tomita; Ryuichiro Ishitani; Shuya Fukai; Osamu Nureki
        NATURE, Oct. 2006, Peer-reviewed
      • Snapshots of tRNA sulphuration via an adenylated intermediate
        Tomoyuki Numata; Yoshiho Ikeuchi; Shuya Fukai; Tsutomu Suzuki; Osamu Nureki
        NATURE, Jul. 2006, Peer-reviewed
      • Structural basis of RNA-dependent recruitment of glutamine to the genetic code
        H Oshikane; K Sheppard; S Fukai; Y Nakamura; R Ishitani; T Numata; RL Sherrer; L Feng; E Schmitt; M Panvert; S Blanquet; Y Mechulam; D Soll; O Nureki
        SCIENCE, Jun. 2006, Peer-reviewed
      • Crystallization and preliminary X-ray analysis of the tRNA thiolation enzyme MnmA from Escherichia coli complexed with tRNA(Glu)
        T Numata; Y Ikeuchi; S Fukai; H Adachi; H Matsumura; K Takano; S Murakami; T Inoue; Y Mori; T Sasaki; T Suzuki; O Nureki
        ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Apr. 2006, Peer-reviewed
      • Purification, crystallization and preliminary X-ray diffraction of SecDF, a translocon-associated membrane protein, from Thermus thermophilus
        T Tsukazaki; H Mori; S Fukai; T Numata; A Perederina; H Adachi; H Matsumura; K Takano; S Murakami; T Inoue; Y Mori; T Sasaki; DG Vassylyev; O Nureki; K Ito
        ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Apr. 2006, Peer-reviewed
      • Structural basis for sulfur relay to RNA mediated by heterohexameric TusBCD complex
        T Numata; S Fukai; Y Ikeuchi; T Suzuki; O Nureki
        STRUCTURE, Feb. 2006, Peer-reviewed
      • Structural basis for anticodon recognition by methionyl-tRNA synthetase
        K Nakanishi; Y Ogiso; T Nakama; S Fukai; O Nureki
        NATURE STRUCTURAL & MOLECULAR BIOLOGY, Oct. 2005, Peer-reviewed
      • Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain
        K Nakanishi; S Fukai; Y Ikeuchi; A Soma; Y Sekine; T Suzuki; O Nureki
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2005, Peer-reviewed
      • Roles of conserved amino acid sequence motifs in the SpoU (TrmH) RNA methyltransferase family
        K Watanabe; O Nureki; S Fukai; R Ishii; H Okamoto; S Yokoyama; Y Endo; H Hori
        JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2005, Peer-reviewed
      • Structural basis for template-independent RNA polymerization
        K Tomita; S Fukai; R Ishitani; T Ueda; N Takeuchi; DG Vassylyev; O Nureki
        NATURE, Aug. 2004, Peer-reviewed, Lead author
      • Deep knot structure for construction of active site and cofactor binding site of tRNA modification enzyme
        O Nureki; K Watanabe; S Fukai; R Ishii; Y Endo; H Hori; S Yokoyama
        STRUCTURE, Apr. 2004, Peer-reviewed
      • A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase
        Y Kise; SW Lee; SG Park; S Fukai; T Sengoku; R Ishii; S Yokoyama; S Kim; O Nureki
        NATURE STRUCTURAL & MOLECULAR BIOLOGY, Feb. 2004, Peer-reviewed
      • Crystal structures of the CP1 domain from Thermus thermophilus isoleucyl-tRNA synthetase and its complex with L-valine
        R Fukunaga; S Fukai; R Ishitani; O Nureki; S Yokoyama
        JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2004, Peer-reviewed
      • A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase
        Yoshiaki Kise; Sang Won Lee; Sang Gyu Park; Shuya Fukai; Toru Sengoku; Ryohei Ishii; Shigeyuki Yokoyama; Sunghoon Kim; Osamu Nureki
        Nature Structural and Molecular Biology, Feb. 2004, Peer-reviewed
      • Structural basis of the interaction between RalA and Sec5, a subunit of the sec6/8 complex
        S Fukai; HT Matern; Jagath, JR; RH Scheller; AT Brunger
        EMBO JOURNAL, Jul. 2003, Peer-reviewed, Lead author
      • Mechanism of molecular interactions for tRNA(Val) recognition by valyl-tRNA synthetase
        S Fukai; O Nureki; S Sekine; A Shimada; DG Vassylyev; S Yokoyama
        RNA-A PUBLICATION OF THE RNA SOCIETY, Jan. 2003, Peer-reviewed
      • Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains
        H Ogiso; R Ishitani; O Nureki; S Fukai; M Yamanaka; JH Kim; K Saito; A Sakamoto; M Inoue; M Shirouzu; S Yokoyama
        CELL, Sep. 2002, Peer-reviewed
      • Crystal structure of the homologous-pairing domain from the human Rad52 recombinase in the undecameric form
        W Kagawa; H Kurumizaka; R Ishitani; S Fukai; O Nureki; T Shibata; S Yokoyama
        MOLECULAR CELL, Aug. 2002, Peer-reviewed
      • Crystal structure of archaeosine tRNA-guanine transglycosylase
        R Ishitani; O Nureki; S Fukai; T Kijimoto; N Nameki; M Watanabe; H Kondo; M Sekine; N Okada; S Nishimura; S Yokoyama
        JOURNAL OF MOLECULAR BIOLOGY, May 2002, Peer-reviewed
      • Mutational separation of two pathways for editing by a class I tRNA synthetase
        TL Hendrickson; TK Nomanbhoy; de Crecy-Lagard, V; S Fukai; O Nureki; S Yokoyama; P Schimmel
        MOLECULAR CELL, Feb. 2002, Peer-reviewed
      • Crystal structure of the CENP-B protein-DNA complex: the DNA-binding domains of CENP-B induce kinks in the CENP-B box DNA
        Y Tanaka; O Nureki; H Kurumizaka; S Fukai; S Kawaguchi; M Ikuta; J Iwahara; T Okazaki; S Yokoyama
        EMBO JOURNAL, Dec. 2001, Peer-reviewed
      • Crystal structure of human AUH protein, a single-stranded RNA binding homolog of enoyl-CoA hydratase
        K Kurimoto; S Fukai; O Nureki; Y Muto; S Yokoyama
        STRUCTURE, Dec. 2001, Peer-reviewed
      • Structural basis for double-sieve discrimination of L-valine from L-isoleucine and L-threonine by the complex of tRNA(Val) and valyl-tRNA synthetase
        S Fukai; O Nureki; S Sekine; A Shimada; JS Tao; DG Vassylyev; S Yokoyama
        CELL, Nov. 2000, Peer-reviewed
      • Enzyme structure with two catalytic sites for double-sieve selection of substrate
        O Nureki; DG Vassylyev; M Tateno; A Shimada; T Nakama; S Fukai; M Konno; TL Hendrickson; P Schimmel; S Yokoyama
        SCIENCE, Apr. 1998, Peer-reviewed
      • Neurexins play a crucial role in cerebellar granule cell survival by organizing autocrine machinery for neurotrophins
        Takeshi Uemura; Emi Suzuki-Kouyama; Shiori Kawase; Taiga Kurihara; Misato Yasumura; Tomoyuki Yoshida; Shuya Fukai; Maya Yamazaki; Peng Fei; Manabu Abe; Masahiko Watanabe; Kenji Sakimura; Masayoshi Mishina; Katsuhiko Tabuchi
        Cell Reports, Apr. 2022, Peer-reviewed

      Misc.

      • Mechanism for the specific cleavage of Lys63-linked polyubiquitin chains
        佐藤 裕介; 深井 周也
        生体の科学, Nov. 2009
      • 遺伝子点変異による精神神経疾患の発症機構解明 シナプスオーガナイザー遺伝子点変異導入マウスを用いた神経発達障害発症機構の解明
        吉田 知之; 山形 敦史; 田端 彩子; 和泉 宏謙; 城島 知子; 金 主賢; 深田 優子; 深田 正紀; 高雄 啓三; 森 寿; 深井 周也
        日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, Sep. 2017
      • 1SE55 Structural insight into meeting and parting complexes of proteins and RNA(s)
        Numata T.; Fukai S.; Oshikane Y.; Nakamura Y.; Suzuki T.; Nureki O.
        Seibutsu Butsuri, 2005
      • ユビキチン・コード:細胞内の最も難解な暗号を読む USP30によるLys6結合型ユビキチン鎖特異的切断機構の構造的基盤
        佐藤 裕介; 尾勝 圭; 佐伯 泰; 山野 晃史; 松田 憲之; 海保 愛; 山形 敦史; 伊藤 桜子; 石川 稔; 橋本 祐一; 田中 啓二; 深井 周也
        生命科学系学会合同年次大会, Dec. 2017
      • Roles of type IIa receptor protein tyrosine phosphatases as synaptic organizers
        Shuya Fukai; Tomoyuki Yoshida
        The FEBS Journal, 10 Dec. 2020, Peer-reviewed, Invited, Lead author, Corresponding author
      • Frontiers in structural biology of synaptic adhesion molecules
        Shuya Fukai
        Journal of Japanese Biochemical Society, Apr. 2020, Peer-reviewed, Invited
      • Trans-scale understanding of cellular communications: neuronal synapse development
        Shuya Fukai
        実験医学, Mar. 2020, Peer-reviewed, Invited
      • Insights into the mechanisms of epilepsy from structural biology of LGI1-ADAM22.
        Atsushi Yamagata; Shuya Fukai
        Cellular and molecular life sciences : CMLS, Jan. 2020, Peer-reviewed
      • Structural insights into leucine-rich repeat-containing synaptic cleft molecules.
        Atsushi Yamagata; Shuya Fukai
        Current opinion in structural biology, Feb. 2019, Peer-reviewed
      • Structural basis of synaptic organizer complexes for inducing synapse formation in the central nervous system
        深井周也; 山形敦史
        生化学, Jun. 2016, Peer-reviewed, Invited
      • 神経細胞間シナプス形成とその調節メカニズム
        山形敦史; 深井周也
        日本結晶学会誌, Oct. 2015, Peer-reviewed, Invited
      • シナプス形成を誘導する膜受容体の機能と構造
        深井周也; 植村 健; 吉田知之
        実験医学 増刊, 2014
      • The regulation of cell function by linkage-specific polyubiquitin binding
        Yusuke Sato; Shuya Fukai
        Seikagaku, 2012, Peer-reviewed
      • Mechanism for de-ubiquitination of K 63-linked polyubiquitin chains
        Shuya Fukai
        Seikagaku, 2009, Peer-reviewed
      • Expectation for the cell-free synthesis of the multisubunit complex towards the three-dimensional structure determination
        Shuya Fukai
        SEIKAGAKU, Mar. 2007, Peer-reviewed
      • 古細菌のグルタミン翻訳系にかかわる酵素類の結晶構造解析
        石谷隆一郎; 押鐘浩之; 大森淳彦; SHEPPARD Kelly; 渡邉信久; 深井周也; SOLL Dieter; 濡木理
        生化学, 2007

      Presentations

      • ユビキチンリガーゼUBE3Aは26Sプロテアソームの負の調節因子である
        土屋光; 尾勝圭; 田中啓二; 深井周也; 佐伯泰
        日本分子生物学会年会プログラム・要旨集(Web), 2020
      • PINK1 activation by its unconventional localization to the outer mitochondrial membrane
        尾勝圭; 松田憲之; 深井周也
        日本分子生物学会年会プログラム・要旨集(Web), 2019
      • 大腸菌のtRNAArgを切断するリボヌクレアーゼ毒素,コリシンDの分子構造解析
        張榮維; 佐藤裕介; 小川哲弘; 荒川孝俊; 伏信進矢; 深井周也; 正木春彦
        日本蛋白質科学会年会プログラム・要旨集, 2017
      • USP30によるLys6結合型ユビキチン鎖特異的切断機構の構造的基盤
        佐藤裕介; 尾勝圭; 佐伯泰; 山野晃史; 松田憲之; 海保愛; 山形敦史; 伊藤桜子; 石川稔; 橋本祐一; 田中啓二; 深井周也
        日本生化学会大会(Web), 2017
      • 3S2-3 Crystal structure of bacterial Sec translocon(3S2 Structural basis for membrane-mediated transport and signal conversion,The 46th Annual Meeting of the Biophysical Society of Japan)
        Tsukazaki Tomoya; Mori Hiroyuki; Fukai Shuya; Ishitani Ryuichiro; Perederina Anna; Vassylyev Dmitry G.; Ito Koreaki; Nureki Osamu
        Seibutsu Butsuri, 2008, The Biophysical Society of Japan General Incorporated Association
      • 1P-033 Crystal structures of the cytosolic domain of the Mg^<2+> transporter MgtE(The 46th Annual Meeting of the Biophysical Society of Japan)
        Tanaka Yoshiki; Hattori Motoyuki; Fukai Shuya; Ishitani Ryuichiro; Nureki Osamu
        Seibutsu Butsuri, 2008, The Biophysical Society of Japan General Incorporated Association
      • Structural biology of enzyme families that ensure the fidelity of protein biosynthesis
        Nureki O.; Shirouzu M.; Shimada A.; Nakama T.; Fukai S.; Ishitani R.; Hashimoto K.; Vassylyev Dmitry G.; Yokoyama S.
        Seibutsu Butsuri, 2000, The Biophysical Society of Japan General Incorporated Association
      • Crystal structure of isolcucyl-tRNA synthetase with two cat alytic sites for double-sieve amino-acid selection
        Nureki O.; Vassylyev D.G.; Tateno M.; Shimada M.; Nalama T.; Fukai S.; Konno M.; Hendrickson T.L.; Schimmel P.; Yokoyama S.
        Biophysics, 07 Sep. 1998, The Biophysical Society of Japan General Incorporated Association
      • ケモテクノロジーが拓くユビキチンニューフロンティア ヒトDUBアレイ技術を用いたUSP特異的阻害剤の開発
        高橋 宏隆; 山中 聡士; 桑田 翔平; 檜垣 佳奈; 佐藤 裕介; 深井 周也; 徳永 文稔; 澤崎 達也
        日本生化学会大会プログラム・講演要旨集, Sep. 2020, (公社)日本生化学会
      • コムギ無細胞タンパク質合成系を基盤としたヒト脱ユビキチン化酵素タンパク質アレイの作製と応用
        高橋宏隆; 山中聡士; 後藤栄治; 及川大輔; 佐藤裕介; 深井周也; 徳永文稔; 澤崎達也
        日本病態プロテアーゼ学会学術集会プログラム抄録集, 2019
      • Npl4によるユビキチン鎖認識およびUfd1結合様式の構造基盤
        佐藤裕介; 土屋光; 田中啓二; 佐伯泰; 深井周也
        日本細胞生物学会大会(Web), 2019
      • コムギ無細胞系を用いて作製したヒト脱ユビキチン化酵素(DUB)プロテインアレイによるポリユビキチン鎖基質特異性解析とDUB阻害剤の選択性評価
        高橋宏隆; 山中聡士; 桑田翔平; 後藤栄治; 今井賢一郎; 富井健太郎; 佐藤裕介; 深井周也; 徳永文稔; 澤崎達也
        日本分子生物学会年会プログラム・要旨集(Web), 2018
      • ユビキチン・コード:細胞内の最も難解な暗号を読む USP30によるLys6結合型ユビキチン鎖特異的切断機構の構造的基盤
        佐藤 裕介; 尾勝 圭; 佐伯 泰; 山野 晃史; 松田 憲之; 海保 愛; 山形 敦史; 伊藤 桜子; 石川 稔; 橋本 祐一; 田中 啓二; 深井 周也
        生命科学系学会合同年次大会, Dec. 2017, 生命科学系学会合同年次大会運営事務局
      • 遺伝子点変異による精神神経疾患の発症機構解明 シナプスオーガナイザー遺伝子点変異導入マウスを用いた神経発達障害発症機構の解明
        吉田 知之; 山形 敦史; 田端 彩子; 和泉 宏謙; 城島 知子; 金 主賢; 深田 優子; 深田 正紀; 高雄 啓三; 森 寿; 深井 周也
        日本生物学的精神医学会・日本神経精神薬理学会合同年会プログラム・抄録集, Sep. 2017, 日本生物学的精神医学会・日本神経精神薬理学会
      • 2SEA-06 Comments from the point of view of structural biology(2SEA Biophysical views in structural cell biology,Symposium,The 51th Annual Meeting of the Biophysical Society of Japan)
        Fukai Shuya
        Seibutsu Butsuri, 2013, The Biophysical Society of Japan General Incorporated Association
      • Secトランスロコンと共に機能するSecDF膜蛋白質の結晶構造
        塚崎智也; 森博幸; 越前友香; 石谷隆一郎; 深井周也; PEREDERINA Anna; VASSYLYEV; Dmitry G; 田中剛史; 河野俊之; 伊藤維昭; 濡木理
        日本蛋白質科学会年会プログラム・要旨集, 15 May 2010
      • Crystal structure of SecDF, a Sec translocon-associated membrane protein.
        Tsukazaki T; Mori H; Echizen Y; Ishitani R; Fukai S; Tanaka T; Perederina A; Vassylyev D G; Kohno H; Echizen Y; Ishitani R; Fukai S; Tanaka T; Perederina A; Vassylyev D G; Kohno T; Ito K; Nureki O
        The 3rd International Symposium on Protein Community, Nara, September 13-16, 2010, 2010
      • 細菌型Secトランスロコンの構造から明らかとなったタンパク質膜透過装置の構造変化
        塚崎智也; 森博幸; 深井周也; 石谷隆一郎; 森貴治; 堂前直; PEREDERINA Anna; 杉田有治; VASSYLYEV; Dmitry G; 伊藤維昭; 濡木理
        日本蛋白質科学会年会プログラム・要旨集, 24 Apr. 2009
      • 細菌型Secトランスロコンの構造から明らかとなったタンパク質膜透過装置の構造変化
        塚崎智也; 森博幸; 深井周也; 石谷隆一郎; 森貴治; 堂前直; PEREDERINA Anna; 杉田有治; VASSYLYEV Dmitry G.; 伊藤維昭; 濡木理
        日本蛋白質科学会年会プログラム・要旨集, 2009
      • 細菌型Sec トランスロコン腹合体の結晶構析
        Tsukazaki, T; Mori, H; Fukai, S; Ishitani, R; Perederina, A; Vassylyev, D. G; Ito, K; Nureki
        第46 回日本生物物理学会、福岡、2008 年12 月 3-5 日, 2008
      • Crystal structure of T. thermophilus Sec translocon with an Fab fragment implies a translocation-initiating state of SecY.
        Tsukazaki T; Mori H; Fukai S; Ishitani R; Mori T; Dohmae N; Perederina A; Sugita Y; Vassylyev D. G; Ito K; Nureki O
        シンポジウム 「タンパク機発現システム - シャペロンからトランスロケーターまで」 第 回日本分子生物学会年会、第 回日本生化学会大会 合同大会 神戸 2008 年12月9-12 日, 2008
      • S06A2 Structural insights into the chemical modification in non-coding RNAs(Structural Biology of ncRNA Processing and Function)
        Numata Tomoyuki; Nakanishi Kotaro; Suzuki Yoko; Noma Akiko; Ikeuchi Yoshiho; Suzuki Tsutomu; Fukai Shuya; Ishitani Ryuichiro; Nureki Osamu
        Biophysics, 20 Nov. 2007, The Biophysical Society of Japan
      • 1P014 Snapshots of tRNA sulfuration via an adenylated intermediate(1. Protein structure and dynamics (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
        Numata Tomoyuki; Ikeuchi Yoshiho; Fukai Shuya; Suzuki Tsutomu; Nureki Osamu
        Biophysics, 01 Oct. 2006, The Biophysical Society of Japan
      • 高度好熱菌由来トランスロコン関連膜タンパク質SecDFの精製・結晶化ならびにX線回折
        塚崎智也; 森博幸; 深井周也; 沼田倫征; PEREDERINA Anna; 安達宏昭; 松村浩由; 高野和文; 村上聡; 井上豪; 森勇介; 佐々木孝友; VASSYLYEV; Dmitry G; 濡木理; 伊藤維昭
        日本蛋白質科学会年会プログラム・要旨集, 31 Mar. 2006
      • タンパク3000プロジェクト「転写・翻訳」拠点の成果(23)-メタン菌特有システイニル及びセレノシステイニルtRNA形成機構の立体構造解析
        荒磯裕平; 押鐘浩之; 深井周也; SALAZAR Juan; YUAN Jing; SOLL Dieter; 濡木理
        日本蛋白質科学会年会プログラム・要旨集, 2006
      • タンパク3000プロジェクト「転写・翻訳」拠点の成果(21)-古細菌特有アミノ基転移酵素GatDE/tRNA複合体の立体構造解析
        押鐘浩之; 中村裕子; 深井周也; 石谷隆一郎; SHEPPARD Kelly; FENG Liang; SOLL Dieter; 濡木理
        日本蛋白質科学会年会プログラム・要旨集, 2006
      • 3P219 Preparation of the mammalian Exocyst complex for the three-dimensional structure determination
        Fukai S; Shirakawa R; Horiuchi H; Mio K; Maruyama Y; Sato C; Nureki O
        Biophysics, 19 Oct. 2005, The Biophysical Society of Japan
      • Structural change of tRNA (Gm18) methyltransferase by binding of methyl donor analogues.
        Watanabe K; Nureki O; Fukai S; Endo Y; Hori H
        Nucleic acids symposium series (2004), 2005
      • Structural analysis of Thermus thermophilus protein translocation complexes.
        Tsukazaki T; Mori H; Peredrerina A; Vassylyev D. G; Fukai S; Nureki O; Ito K
        International Symposium on Life of Proteins. Maturation, Translocation and Quality Control in the Cell. 10.30-11.3, Awajisima, Hyogo, Japan, 2005, 2005
      • 2P060 Crystal structure of TilS : implications for reaction mechanism
        Nakanishi K; Fukai S; Ikeuchi Y; Soma A; Suzuki T; Nureki O
        Seibutsu Butsuri, 2004, The Biophysical Society of Japan General Incorporated Association
      • 2P059 Crystallization of the TsuBCD complex
        Numata N; Fukai S; Ikeuchi Y; Suzuki T; Nureki O
        Seibutsu Butsuri, 2004, The Biophysical Society of Japan General Incorporated Association
      • The Activation Mechanism of the Epidermal Growth Factor Receptor
        SAITO Kazuki; OGISO Hideo; ISHITANI Ryuichiro; NUREKI Osamu; FUKAI Shuya; YAMANAKA Mari; KIM Jae-Hoon; SHIROUZU Mikako; YOKOYAMA Shigeyuki
        Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Feb. 2003
      • Structural basis for amino acid and tRNA recognition by class I aminoacyl-tRNA synthetases
        O Nureki; S Fukai; S Sekine; A Shimada; T Terada; T Nakama; M Shirouzu; DG Vassylyev; S Yokoyama
        COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 2001, COLD SPRING HARBOR LAB PRESS

      External funds: Kakenhi

      • Ubiquitin structural biology providing the molecular basis for chemo-technologies
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Complex systems
        Kyoto University;The University of Tokyo
        深井 周也
        From 29 Jun. 2018, To 31 Mar. 2023, Granted
        構造生物学;分子間相互作用;ユビキチン;シグナル伝達;タンパク質工学;ケミカルバイオロジー;キメラ化合物
      • New frontier for ubiquitin biology driven by chemo-technologies
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Complex systems
        Tokyo Metropolitan Institute of Medical Science
        佐伯 泰
        From 29 Jun. 2018, To 31 Mar. 2023, Granted
        ユビキチン;ケミカルバイオロジー;翻訳後修飾;タンパク質分解;シグナル伝達;ステープルペプチド
      • Structural analysis of the epilepsy-related protein complex LGI1-ADAM22-PSD-95 and its regulatory factors
        Grant-in-Aid for Scientific Research (A)
        Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
        Kyoto University;The University of Tokyo
        深井 周也
        From 01 Apr. 2018, To 31 Mar. 2022, Granted
        構造生物学;分子間相互作用;膜受容体;てんかん;シナプス;足場タンパク質;パルミトイル化;パルミトリル化
      • BRCC36複合体によるK63結合型ユビキチン鎖特異的切断メカニズムの解明
        Grant-in-Aid for JSPS Fellows
        The University of Tokyo
        From 09 Nov. 2015, To 31 Mar. 2018, Project Closed
        分子認識;DNA修復;タンパク質複合体;ユビキチン;X線結晶構造解析;構造生物学;X線結晶構造解析
      • Structural basis for ubiquitin chain-mediated DNA damage responses
        Grant-in-Aid for Scientific Research (A)
        The University of Tokyo
        Shuya Fukai
        From 01 Apr. 2012, To 31 Mar. 2016, Project Closed
        分子認識;DNA修復;タンパク質複合体;ユビキチン;X線結晶構造解析;構造生物学;X線結晶構造解析
      • X-ray crystallography of molecular complexes regulating vesicular trafficking
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        The University of Tokyo
        Shuya FUKAI
        From 01 Apr. 2010, To 31 Mar. 2015, Project Closed
        分子認識;シグナル伝達;タンパク質複合体;X線結晶構造解析;構造生物学;小胞輸送;低分子量GTPase
      • Structural basis of cell-signaling complexes mediating signal perception, transduction and responses.
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        Nara Institute of Science and Technology
        Toshio HAKOSHIMA
        From 01 Apr. 2010, To 31 Mar. 2015, Project Closed
        構造生物学;生化学;細胞生物学;分子生物学;生物物理学;タンパク質;相互作用;X線結晶学;NMR;電子顕微鏡;複合体;シグナル伝達
      • Structural biology of polyubuiquitin chain recognition
        Grant-in-Aid for Young Scientists (A)
        The University of Tokyo
        Shuya FUKAI
        Project Closed
        X線結晶構造解析;ユビキチン;分子間相互作用;炎症シグナル;DNA損傷応答;シグナル伝達;生体分子;蛋白質;分子認識
      • 膜蛋白質のコンフォメーション特異的な結晶化を可能にする抗体断片の開発
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        The University of Tokyo
        三村 久敏
        Project Closed
        植物;膜蛋白質;膜輸送体;H^+ポンプ;抗体断片;結晶化;X線結晶解析
      • Exocyst複合体の再構成と構造解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        The University of Tokyo
        深井 周也
        Project Closed
        低分子量GTPase;X線結晶構造解析;シグナル伝達;生体分子;蛋白質;分子認識;膜タンパク質;小胞輸送;膜融合;分子間相互作用
      • Structural basis for the activation of Rab GTPases
        Grant-in-Aid for Young Scientists (B)
        The University of Tokyo
        Shuya FUKAI
        Project Closed
        X線結晶構造解析;低分子量GTPase;分子間相互作用;膜タンパク質;小胞輸送;膜融合;グアニンヌクレオチド交換因子
      • Yipタンパク質ファミリーの結晶構造解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        The University of Tokyo
        深井 周也
        Project Closed
        X線結晶構造解析;膜タンパク質;低分子量GTPase;小胞輸送;膜融合;分子間相互作用
      • 開口放出で働く繋留因子Exocyst複合体の立体構造解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        The University of Tokyo;Tokyo Institute of Technology
        深井 周也
        Project Closed
        X線結晶構造解析;電子顕微鏡;超分子複合体;小胞輸送;低分子量GTPase;開口放出;膜融合
      • 開口放出を制御するタンパク質複合体群の立体構造解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Tokyo Institute of Technology
        深井 周也
        Project Closed
        X線結晶構造解析;小胞輸送;電子顕微鏡;繋留因子;開口放出;膜融合
      • X線結晶構造解析に基づく嗅覚・味覚・温覚レセプターの情報変換メカニズムの解明
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Tokyo Institute of Technology
        深井 周也
        Project Closed
        X線結晶構造解析;膜タンパク質;イオン輸送体;受容体;膜透過装置;イオンチャネル;Gタンパク質共役型受容体
      • 分子シャペロンのX線結晶構造解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Tokyo Institute of Technology
        深井 周也
        Project Closed
        X線結晶構造解析;シャペロン;膜透過装置;膜タンパク質;ATPase
      • 繋留因子群の立体構造解析による膜融合制御機構の解明
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Tokyo Institute of Technology
        深井 周也
        Project Closed
        X線結晶構造解析;小胞輸送;電子顕微鏡;繋留因子;開口放出;膜融合;small GTPase
      • ラットSec6/8複合体の構造・機能解析による,膜融合制御機構の解明
        Grant-in-Aid for Young Scientists (B)
        Tokyo Institute of Technology
        深井 周也
        Project Closed
        X線結晶構造解析;小胞輸送;電子顕微鏡;繋留因子;開口放出;膜融合;small GTPase
      list
        Last Updated :2022/08/06

        Education

        Teaching subject(s)

        • From 01 Apr. 2022, To 31 Mar. 2023
          Exercises in Biochemistry
          3628, Fall, Faculty of Science, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Correlation Chemistry IIB
          7205, Fall, Graduate School of Science, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar on Correlation Chemistry IIA
          7100, Spring, Graduate School of Science, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Correlation Chemistry IIC
          7206, Spring, Graduate School of Science, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Biochemistry IV
          4614, Spring, Faculty of Science, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Correlation Chemistry IID
          7207, Fall, Graduate School of Science, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar on Correlation Chemistry IIB
          7101, Fall, Graduate School of Science, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Principles of Chemical Biology
          7001, Spring, Graduate School of Science, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar on Correlation Chemistry IID
          7103, Fall, Graduate School of Science, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Biochemistry I
          2626, Fall, Faculty of Science, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Correlation Chemistry IIA
          7204, Spring, Graduate School of Science, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar on Correlation Chemistry IIC
          7102, Spring, Graduate School of Science, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Special study course II (Chemistry) 2
          5629, Year-long, Faculty of Science, 12
        • From 01 Apr. 2022, To 31 Mar. 2023
          Special Lecture on Chemistry 6
          7253, Year-long, Graduate School of Science, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Biochemistry II
          8601, Spring, Faculty of Science, 2
        • From Apr. 2020, To Mar. 2021
          Special study course II (Chemistry) 2
          Year-long, 理学部
        • From Apr. 2020, To Mar. 2021
          Biochemistry I
          Fall, 理学部
        • From Apr. 2020, To Mar. 2021
          Exercises in Biochemistry
          Fall, 理学部
        • From Apr. 2020, To Mar. 2021
          Seminar on Correlation Chemistry IIA
          Spring, 理学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar on Correlation Chemistry IIB
          Fall, 理学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar on Correlation Chemistry IIC
          Spring, 理学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar on Correlation Chemistry IID
          Fall, 理学研究科
        • From Apr. 2020, To Mar. 2021
          Advanced Correlation Chemistry IIA
          Spring, 理学研究科
        • From Apr. 2020, To Mar. 2021
          Advanced Correlation Chemistry IIB
          Fall, 理学研究科
        • From Apr. 2020, To Mar. 2021
          Advanced Correlation Chemistry IIC
          Spring, 理学研究科
        • From Apr. 2020, To Mar. 2021
          Advanced Correlation Chemistry IID
          Fall, 理学研究科
        • From Apr. 2021, To Mar. 2022
          Special study course II (Chemistry) 2
          Year-long, 理学部
        • From Apr. 2021, To Mar. 2022
          Advanced Structural Biochemistry
          Fall, 理学研究科
        • From Apr. 2021, To Mar. 2022
          Biochemistry I
          Fall, 理学部
        • From Apr. 2021, To Mar. 2022
          Exercises in Biochemistry
          Fall, 理学部
        • From Apr. 2021, To Mar. 2022
          Seminar on Correlation Chemistry IIA
          Spring, 理学研究科
        • From Apr. 2021, To Mar. 2022
          Seminar on Correlation Chemistry IIB
          Fall, 理学研究科
        • From Apr. 2021, To Mar. 2022
          Seminar on Correlation Chemistry IIC
          Spring, 理学研究科
        • From Apr. 2021, To Mar. 2022
          Seminar on Correlation Chemistry IID
          Fall, 理学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced Correlation Chemistry IIA
          Spring, 理学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced Correlation Chemistry IIB
          Fall, 理学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced Correlation Chemistry IIC
          Spring, 理学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced Correlation Chemistry IID
          Fall, 理学研究科

        Participation in PhD Defense

        • Investigating Advanced Properties of Modular DNAs as Biohybrid Catalyst and Aptamer
          Yum Ji Hye, Graduate School of Science, Sub-chief Examiner
          23 Mar. 2022
        • Biomolecular nanotechnology-based approaches to investigate nucleic acid interactions
          SHUBHAM MISHRA, Graduate School of Science, Sub-chief Examiner
          23 Mar. 2022
        • DNA based Photo-controllable Extracellular Matrix-like Scaffolds to Understand and Control Cell Behaviour
          SOUMYA SETHI, Graduate School of Science, Sub-chief Examiner
          23 Mar. 2022
        list
          Last Updated :2022/08/06

          Administration

          Faculty management (title, position)

          • From 01 Apr. 2022, To 31 Mar. 2023
            理学研究科将来計画委員会委員
          • From 01 Apr. 2022, To 31 Mar. 2023
            理学研究科自己点検・評価委員会委員
          • From 01 Apr. 2022, To 31 Mar. 2023
            理学研究科大学院教育常任委員会委員
          • From 01 Apr. 2022, To 31 Mar. 2023
            理学研究科大学院教育教務委員会委員
          • From 01 Apr. 2022, To 31 Mar. 2023
            理学研究科放射線委員会委員
          • From 01 Apr. 2022, To 31 Mar. 2023
            理学研究科研究科会議構成員
          • From 01 Apr. 2022, To 31 Mar. 2023
            理学研究科専攻長会議構成員
          • From 01 Apr. 2022, To 31 Mar. 2023
            理学研究科危機管理委員会委員
          • From 20 Jan. 0004, To 21 0003
            理学研究科SACRA広報・社会連携部門委員会委員
          • From 20 Jan. 0004, To 21 0003
            理学研究科SACRA広報・社会連携部門委員会 広報小委員会委員
          • From 01 Apr. 2020, To 31 Mar. 2021
            理学研究科SACRA広報・社会連携部門委員会委員
          • From 01 Apr. 2020, To 31 Mar. 2021
            理学研究科SACRA広報・社会連携部門委員会 広報小委員会委員
          • From 01 Apr. 2021, To 31 Mar. 2022
            理学研究科将来計画委員会委員
          • From 01 Apr. 2021, To 31 Mar. 2022
            理学研究科自己点検・評価委員会委員
          • From 01 Apr. 2021, To 31 Mar. 2022
            理学研究科大学院教育常任委員会委員
          • From 01 Apr. 2021, To 31 Mar. 2022
            理学研究科大学院教育教務委員会委員
          • From 01 Apr. 2021, To 31 Mar. 2022
            理学研究科放射線委員会委員
          • From 01 Apr. 2021, To 31 Mar. 2022
            理学研究科放射線障害防止委員会委員
          • From 01 Apr. 2021, To 31 Mar. 2023
            理学研究科サイエンス連携探索センター(SACRA)運営協議会委員
          • From 01 Apr. 2021, To 31 Mar. 2022
            理学研究科SACRA広報・社会連携部門委員会委員
          • From 01 Apr. 2021, To 31 Mar. 2022
            理学研究科SACRA広報・社会連携部門委員会 広報小委員会委員長
          • From 01 Apr. 2021, To 31 Mar. 2022
            理学研究科研究科会議構成員

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