Basic Information

Affiliated programs (koza)

• Graduate School of Engineering, 高分子化学専攻 医用高分子講座, 教授

Concurrent Affiliation

• Institute for Advanced Study, ヒト生物学高等研究拠点, 連携研究者
• Institute for Advanced Study, ヒト生物学高等研究拠点, 主任研究者

Academic Degree

• 修士（理学）(京都大学)
• 博士（理学）(京都大学)

Research History

• From Apr. 2022, To Present

  Kyoto University, Institute for Life and Medical Sciences, 教授
• From Feb. 2017, To Mar. 2022

  Kyoto University, Institute for Frontier Life and Medical Sciences, Professor
• From Apr. 2015, To Jan. 2017

  RIKEN, Center for Developmental Biology, Team Leader
• From 2013, To Mar. 2015

  RIKEN, Unit Leader
• From 2006, To 2013

  RIKEN, 研究員
• Kyoto University Institute for Frontier Life and Medical Sciences, Professor

ID,URL

• J-Global ID

  201401084561998300

• Researcher number

  40415097

• External link

  http://www2.infront.kyoto-u.ac.jp/bs01/

researchmap URL

• https://researchmap.jp/eiraku333

Research

Research Interests

• 幹細胞
• 形態形成
• イメージング
• 神経発生
• 試験管内再構築
• ES細胞
• 組織形成
• 細胞間シグナル
• 顆粒細胞
• 樹状突起

Research Areas

• Life sciences, Developmental biology

Papers

• The gut contractile organoid: a novel model for studying the gut motility regulated by coordinating signals between interstitial cells of Cajal and smooth muscles

  Rei Yagasaki; Ryo Nakamura; Yuuki Shikaya; Ryosuke Tadokoro; Ruolin Hao; Zhe Wang; Mototsugu Eiraku; Masafumi Inaba; Yoshiko Takahashi

  13 Mar. 2024

  
• Spatial cell fate manipulation of human pluripotent stem cells by controlling the microenvironment using photocurable hydrogel

  Zhe Wang; Akira Numada; Fumi Wagai; Yusuke Oda; Masatoshi Ohgushi; Koichiro Maki; Taiji Adachi; Mototsugu Eiraku

  Development, 15 Mar. 2024, Peer-reviewed

  
• In vitro induction of patterned branchial arch-like aggregate from human pluripotent stem cells

  Yusuke Seto; Ryoma Ogihara; Kaori Takizawa; Mototsugu Eiraku

  Nature Communications, 14 Feb. 2024, Peer-reviewed

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• RENGE infers gene regulatory networks using time-series single-cell RNA-seq data with CRISPR perturbations.

  Masato Ishikawa; Seiichi Sugino; Yoshie Masuda; Yusuke Tarumoto; Yusuke Seto; Nobuko Taniyama; Fumi Wagai; Yuhei Yamauchi; Yasuhiro Kojima; Hisanori Kiryu; Kosuke Yusa; Mototsugu Eiraku; Atsushi Mochizuki

  Communications biology, 28 Dec. 2023, Peer-reviewed

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• How might we build limbs in vitro informed by the modular aspects and tissue-dependency in limb development?

  Rio Tsutsumi; Mototsugu Eiraku

  Frontiers in Cell and Developmental Biology, 22 May 2023, Peer-reviewed

  
• Collective nuclear behavior shapes bilateral nuclear symmetry for subsequent left-right asymmetric morphogenesis in Drosophila

  D. Shin; M. Nakamura; Y. Morishita; M. Eiraku; T. Yamakawa; T. Sasamura; M. Akiyama; M. Inaki; K. Matsuno

  Development, 2021, Peer-reviewed

  
• Development of intensiometric indicators for visualizing N-cadherin interaction across cells

  Takashi Kanadome; Kanehiro Hayashi; Yusuke Seto; Mototsugu Eiraku; Kazunori Nakajima; Takeharu Nagai; Tomoki Matsuda

  Communications Biology, 07 Oct. 2022, Peer-reviewed

  
• Optogenetic control of apical constriction induces synthetic morphogenesis in mammalian tissues

  Guillermo Martínez-Ara; Núria Taberner; Mami Takayama; Elissavet Sandaltzopoulou; Casandra E. Villava; Miquel Bosch-Padrós; Nozomu Takata; Xavier Trepat; Mototsugu Eiraku; Miki Ebisuya

  Nature Communications, 14 Sep. 2022, Peer-reviewed

  
• Delamination of trophoblast-like syncytia from the amniotic ectodermal analogue in human primed embryonic stem cell-based differentiation model.

  Masatoshi Ohgushi; Nobuko Taniyama; Alexis Vandenbon; Mototsugu Eiraku

  Cell reports, 21 Jun. 2022

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• Pluripotent stem cells in developmental biology (part 2).

  Makoto Ikeya; Yayoi Toyooka; Mototsugu Eiraku

  Development, growth & differentiation, Feb. 2021

  
• Pluripotent stem cells in developmental biology.

  Makoto Ikeya; Yayoi Toyooka; Mototsugu Eiraku

  Development, growth & differentiation, Jan. 2021

  
• Self-organized formation of developing appendages from murine pluripotent stem cells.

  Mori S; Sakakura E; Tsunekawa Y; Hagiwara M; Suzuki T; Eiraku M

  Nat Commun., Aug. 2019, Peer-reviewed, Invited

  
• Toward the formation of neural circuits in human brain organoids.

  Seto Y; Eiraku M

  Curr Opin Cell Biol., Aug. 2019, Peer-reviewed

  
• Medium- to long-term survival and functional examination of human iPSC-derived retinas in rat and primate models of retinal degeneration.

  Hung-Ya Tu; Takehito Watanabe; Hiroshi Shirai; Suguru Yamasaki; Masaharu Kinoshita; Keizo Matsushita; Tomoyo Hashiguchi; Hirotaka Onoe; Take Matsuyama; Atsushi Kuwahara; Akiyoshi Kishino; Toru Kimura; Mototsugu Eiraku; Kiyoshi Suzuma; Takashi Kitaoka; Masayo Takahashi; Michiko Mandai

  EBioMedicine, Jan. 2019, Peer-reviewed

  
• Human brain development and its in vitro recapitulation.

  Seto Y; Eiraku M

  Neurosci Res., Jan. 2019, Peer-reviewed, Invited

  
• Strain-triggered mechanical feedback in self-organizing optic-cup morphogenesis.

  S Okuda; N Takata; Y Hasegawa; M Kawada; Y Inoue; T Adachi; Y Sasai; M Eiraku

  Science advances, Nov. 2018, Peer-reviewed

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• Three-dimensional deformation mode of multicellular epithelial tube under tension and compression tests

  Satoru Okuda; Katsuyuki Unoki; Mototsugu Eiraku; Ken-ichi Tsubota

  Journal of Biomechanical Science and Engineering, Jun. 2018, Peer-reviewed

  
• Combining Turing and 3D vertex models reproduces autonomous multicellular morphogenesis with undulation, tubulation, and branching (vol 8, 2386, 2018)

  Satoru Okuda; Takashi Miura; Yasuhiro Inoue; Taiji Adachi; Mototsugu Eiraku

  SCIENTIFIC REPORTS, Jun. 2018, Peer-reviewed

  
• Establishment of Immunodeficient Retinal Degeneration Model Mice and Functional Maturation of Human ESC-Derived Retinal Sheets after Transplantation.

  Satoshi Iraha; Hung-Ya Tu; Suguru Yamasaki; Takahiro Kagawa; Motohito Goto; Riichi Takahashi; Takehito Watanabe; Sunao Sugita; Shigenobu Yonemura; Genshiro A Sunagawa; Take Matsuyama; Momo Fujii; Atsushi Kuwahara; Akiyoshi Kishino; Naoshi Koide; Mototsugu Eiraku; Hidenobu Tanihara; Masayo Takahashi; Michiko Mandai

  Stem cell reports, 13 Mar. 2018, Peer-reviewed

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• Stem cells and genome editing: approaches to tissue regeneration and regenerative medicine.

  Nozomu Takata; Mototsugu Eiraku

  Journal of human genetics, Feb. 2018, Peer-reviewed

  
• Combining Turing and 3D vertex models reproduces autonomous multicellular morphogenesis with undulation, tubulation, and branching

  Satoru Okuda; Takashi Miura; Yasuhiro Inoue; Taiji Adachi; Mototsugu Eiraku

  SCIENTIFIC REPORTS, Feb. 2018, Peer-reviewed

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• Discovery of mechanical feedback mechanism in organogenesis

  Satoru OKUDA; Mototsugu EIRAKU

  The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2018

  
• Self-patterning of rostral-caudal neuroectoderm requires dual role of Fgf signaling for localized Wnt antagonism

  Nozomu Takata; Eriko Sakakura; Mototsugu Eiraku; Takeya Kasukawa; Yoshiki Sasai

  NATURE COMMUNICATIONS, Nov. 2017, Peer-reviewed

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• An Eye Organoid Approach Identifies Six3 Suppression of R-spondin 2 as a Critical Step in Mouse Neuroretina Differentiation

  Nozomu Takata; Deepti Abbey; Luciano Fiore; Sandra Acosta; Ruopeng Feng; Hyea Jin Gil; Alfonso Lavado; Xin Geng; Ashley Interiano; Geoffrey Neale; Mototsugu Eiraku; Yoshiki Sasai; Guillermo Oliver

  CELL REPORTS, Nov. 2017, Peer-reviewed

  
• Role of molecular turnover in dynamic deformation of a three-dimensional cellular membrane

  Satoru Okuda; Mototsugu Eiraku

  BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, Oct. 2017, Peer-reviewed

  
• A RHO Small GTPase Regulator ABR Secures Mitotic Fidelity in Human Embryonic Stem Cells

  Masatoshi Ohgushi; Maki Minaguchi; Mototsugu Eiraku; Yoshiki Sasai

  STEM CELL REPORTS, Jul. 2017, Peer-reviewed

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• Contractile actin belt and mesh structures provide the opposite dependence of epithelial stiffness on the spontaneous curvature of constituent cells

  Satoru Okuda; Katsuyuki Unoki; Mototsugu Eiraku; Ken-ichi Tsubota

  DEVELOPMENT GROWTH & DIFFERENTIATION, Jun. 2017, Peer-reviewed

  
• Versatile three-dimensional vertex model for analyzing multicellular morphogenesis

  Satoru OKUDA; Mototsugu EIRAKU

  The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2017

  
• Telencephalic tissue formation in 3D stem cell culture

  Taisuke Kadoshima; Hideya Sakaguchi; Mototsugu Eiraku

  Organ Regeneration Based on Developmental Biology, 01 Jan. 2017, Peer-reviewed

  
• Generation of various telencephalic regions from human embryonic stem cells in three-dimensional culture

  Taisuke Kadoshima; Hideya Sakaguchi; Mototsugu Eiraku

  Methods in Molecular Biology, 2017, Peer-reviewed

  
• Generation of a three-dimensional retinal tissue from self-organizing human ESC culture

  Atsushi Kuwahara; Tokushige Nakano; Mototsugu Eiraku

  Methods in Molecular Biology, 2017, Peer-reviewed

  
• Emergence of dorsal-ventral polarity in ESC-derived retinal tissue

  Yuiko Hasegawa; Nozomu Takata; Satoru Okuda; Masako Kawada; Mototsugu Eiraku; Yoshiki Sasai

  DEVELOPMENT, Nov. 2016, Peer-reviewed

  
• Data describing Rax positive optic-vesicle generation from mouse embryonic stem cells in vitro.

  Nozomu Takata; Mototsugu Eiraku; Eriko Sakakura

  Data in brief, Sep. 2016, Peer-reviewed

  
• Modeling cell apoptosis for simulating three-dimensional multicellular morphogenesis based on a reversible network reconnection framework

  Satoru Okuda; Yasuhiro Inoue; Mototsugu Eiraku; Taiji Adachi; Yoshiki Sasai

  BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, Aug. 2016, Peer-reviewed

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• Specification of embryonic stem cell-derived tissues into eye fields by Wnt signaling using rostral diencephalic tissue-inducing culture

  Eriko Sakakura; Mototsugu Eiraku; Nozomu Takata

  MECHANISMS OF DEVELOPMENT, Aug. 2016, Peer-reviewed

  
• Optimized Culture System to Induce Neurite Outgrowth From Retinal Ganglion Cells in Three-Dimensional Retinal Aggregates Differentiated From Mouse and Human Embryonic Stem Cells

  Yuki Maekawa; Akishi Onishi; Keizo Matsushita; Naoshi Koide; Michiko Mandai; Kiyoshi Suzuma; Takashi Kitaoka; Atsushi Kuwahara; Chikafumi Ozone; Tokushige Nakano; Mototsugu Eiraku; Masayo Takahashi

  CURRENT EYE RESEARCH, 2016, Peer-reviewed

  
• Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration

  Hiroshi Shirai; Michiko Mandai; Keizo Matsushita; Atsushi Kuwahara; Shigenobu Yonemura; Tokushige Nakano; Juthaporn Assawachananont; Toru Kimura; Koichi Saito; Hiroko Terasaki; Mototsugu Eiraku; Yoshiki Sasai; Masayo Takahashi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jan. 2016, Peer-reviewed

  
• Functional anterior pituitary generated in self-organizing culture of human embryonic stem cells

  Chikafumi Ozone; Hidetaka Suga; Mototsugu Eiraku; Taisuke Kadoshima; Shigenobu Yonemura; Nozomu Takata; Yutaka Oiso; Takashi Tsuji; Yoshiki Sasai

  NATURE COMMUNICATIONS, Jan. 2016, Peer-reviewed

  
• Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

  Hideya Sakaguchi; Taisuke Kadoshima; Mika Soen; Nobuhiro Narii; Yoshihito Ishida; Masatoshi Ohgushi; Jun Takahashi; Mototsugu Eiraku; Yoshiki Sasai

  NATURE COMMUNICATIONS, Nov. 2015, Peer-reviewed

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• Vertex dynamics simulations of viscosity-dependent deformation during tissue morphogenesis

  Satoru Okuda; Yasuhiro Inoue; Mototsugu Eiraku; Taiji Adachi; Yoshiki Sasai

  BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, Apr. 2015, Peer-reviewed

  
• Generation of a ciliary margin-like stem cell niche from self-organizing human retinal tissue

  Atsushi Kuwahara; Chikafumi Ozone; Tokushige Nakano; Koichi Saito; Mototsugu Eiraku; Yoshiki Sasai

  NATURE COMMUNICATIONS, Feb. 2015, Peer-reviewed

  
• Mechanical control of notochord morphogenesis by extra-embryonic tissues in mouse embryos

  Yu Imuta; Hiroshi Koyama; Dongbo Shi; Mototsugu Eiraku; Toshihiko Fujimori; Hiroshi Sasaki

  MECHANISMS OF DEVELOPMENT, May 2014, Peer-reviewed

  
• Transplantation of Embryonic and Induced Pluripotent Stem Cell-Derived 3D Retinal Sheets into Retinal Degenerative Mice

  Juthaporn Assawachananont; Michiko Mandai; Satoshi Okamoto; Chikako Yamada; Mototsugu Eiraku; Shigenobu Yonemura; Yoshiki Sasai; Masayo Takahashi

  STEM CELL REPORTS, May 2014, Peer-reviewed

  
• 2P137 3D vertex model for revealing mechanics in multicellular morphogenesis(09. Development & Differentiation,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))

  Okuda Satoru; Eiraku Mototsugu; Sasai Yoshiki

  Seibutsu Butsuri, 2014

  
• Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex

  Taisuke Kadoshima; Hideya Sakaguchi; Tokushige Nakano; Mika Soen; Satoshi Ando; Mototsugu Eiraku; Yoshiki Sasai

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 2013, Peer-reviewed

  
• Modeling cell proliferation for simulating three-dimensional tissue morphogenesis based on a reversible network reconnection framework

  Satoru Okuda; Yasuhiro Inoue; Mototsugu Eiraku; Yoshiki Sasai; Taiji Adachi

  BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, Oct. 2013, Peer-reviewed

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• Reversible network reconnection model for simulating large deformation in dynamic tissue morphogenesis

  Satoru Okuda; Yasuhiro Inoue; Mototsugu Eiraku; Yoshiki Sasai; Taiji Adachi

  BIOMECHANICS AND MODELING IN MECHANOBIOLOGY, Aug. 2013, Peer-reviewed

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• Apical contractility in growing epithelium supports robust maintenance of smooth curvatures against cell-division-induced mechanical disturbance

  Satoru Okuda; Yasuhiro Inoue; Mototsugu Eiraku; Yoshiki Sasai; Taiji Adachi

  JOURNAL OF BIOMECHANICS, Jun. 2013, Peer-reviewed

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• Robust Formation and Maintenance of Continuous Stratified Cortical Neuroepithelium by Laminin-Containing Matrix in Mouse ES Cell Culture

  Makoto Nasu; Nozomu Takata; Teruko Danjo; Hideya Sakaguchi; Taisuke Kadoshima; Sugiko Futaki; Kiyotoshi Sekiguchi; Mototsugu Eiraku; Yoshiki Sasai

  PLOS ONE, Dec. 2012, Peer-reviewed

  
• In vitro organogenesis in three dimensions: self-organising stem cells

  Yoshiki Sasai; Mototsugu Eiraku; Hidetaka Suga

  DEVELOPMENT, Nov. 2012, Peer-reviewed

  
• Self-formation of layered neural structures in three-dimensional culture of ES cells

  Mototsugu Eiraku; Yoshiki Sasai

  CURRENT OPINION IN NEUROBIOLOGY, Oct. 2012, Peer-reviewed

  
• Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

  Tokushige Nakano; Satoshi Ando; Nozomu Takata; Masako Kawada; Keiko Muguruma; Kiyotoshi Sekiguchi; Koichi Saito; Shigenobu Yonemura; Mototsugu Eiraku; Yoshiki Sasai

  CELL STEM CELL, Jun. 2012, Peer-reviewed

  
• 1PT219 Simulations of large deformation during tissue morphogenesis using reversible network reconnection model(The 50th Annual Meeting of the Biophysical Society of Japan)

  Okuda Satoru; Inoue Yasuhiro; Eiraku Mototsugu; Sasai Yoshiki; Adachi Taiji

  Seibutsu Butsuri, 2012

  
• Relaxation-expansion model for self-driven retinal morphogenesis A hypothesis from the perspective of biosystems dynamics at the multi-cellular level

  Mototsugu Eiraku; Taiji Adachi; Yoshiki Sasai

  BIOESSAYS, Jan. 2012, Peer-reviewed

  
• Mouse embryonic stem cell culture for generation of three-dimensional retinal and cortical tissues

  Mototsugu Eiraku; Yoshiki Sasai

  NATURE PROTOCOLS, Jan. 2012, Peer-reviewed

  
• Remodeling of Monoplanar Purkinje Cell Dendrites during Cerebellar Circuit Formation

  Megumi Kaneko; Kazuhiko Yamaguchi; Mototsugu Eiraku; Motohiko Sato; Norio Takata; Yoshimoto Kiyohara; Masayoshi Mishina; Hajime Hirase; Tsutomu Hashikawa; Mineko Kengaku

  PLOS ONE, May 2011, Peer-reviewed

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• Self-organizing optic-cup morphogenesis in three-dimensional culture

  Mototsugu Eiraku; Nozomu Takata; Hiroki Ishibashi; Masako Kawada; Eriko Sakakura; Satoru Okuda; Kiyotoshi Sekiguchi; Taiji Adachi; Yoshiki Sasai

  NATURE, Apr. 2011, Peer-reviewed

  
• Subregional Specification of Embryonic Stem Cell-Derived Ventral Telencephalic Tissues by Timed and Combinatory Treatment with Extrinsic Signals

  Teruko Danjo; Mototsugu Eiraku; Keiko Muguruma; Kiichi Watanabe; Masako Kawada; Yuchio Yanagawa; John L. R. Rubenstein; Yoshiki Sasai

  JOURNAL OF NEUROSCIENCE, Feb. 2011, Peer-reviewed

  
• Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem Cells

  Masatoshi Ohgushi; Michiru Matsumura; Mototsugu Eiraku; Kazuhiro Murakami; Toshihiro Aramaki; Ayaka Nishiyama; Keiko Muguruma; Tokushige Nakano; Hidetaka Suga; Mono Ueno; Toshimasa Ishizaki; Hirofumi Suemori; Shuh Narumiya; Hitoshi Niwa; Yoshiki Sasai

  CELL STEM CELL, Aug. 2010, Peer-reviewed

  
• Self-Organized Formation of Polarized Cortical Tissues from ESCs and Its Active Manipulation by Extrinsic Signals

  Mototsugu Eiraku; Kiichi Watanabe; Marni Matsuo-Takasaki; Masako Kawada; Shigenobu Yonemura; Michiru Matsumura; Takafumi Wataya; Ayaka Nishiyama; Keiko Muguruma; Yoshiki Sasail

  CELL STEM CELL, Nov. 2008, Peer-reviewed

  
• Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation

  Takafumi Wataya; Satoshi Ando; Keiko Muguruma; Hanako Ikeda; Kiichi Watanabe; Mototsugu Eiraku; Masako Kawada; Jun Takahashi; Nobuo Hashimoto; Yoshiki Sasai

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2008, Peer-reviewed

  
• Receptor type protein tyrosine phosphatase zeta-pleiotrophin signaling controls endocytic trafficking of DNER that regulates neuritogenesis

  Nobuna Fukazawa; Seisuke Yokoyama; Mototsugu Eiraku; Mineko Kengaku; Nobuaki Maeda

  MOLECULAR AND CELLULAR BIOLOGY, Jul. 2008, Peer-reviewed

  
• Impaired cerebellar functions in mutant mice lacking DNER

  A Tohgo; M Eiraku; T Miyazaki; E Miura; S Kawaguchi; M Nishi; M Watanabe; T Hirano; M Kengaku; H Takeshima

  MOLECULAR AND CELLULAR NEUROSCIENCE, Feb. 2006, Peer-reviewed

  
• DNER acts as a neuron-specific Notch ligand during Bergmann glial development

  M Eiraku; A Tohgo; K Ono; M Kaneko; K Fujishima; T Hirano; M Kengaku

  NATURE NEUROSCIENCE, Jul. 2005, Peer-reviewed

  
• 小脳ニューロン・グリアの細胞形態形成を制御する細胞間相互作用 (特集 脳の発生分化と回路形成)

  永樂元次; 見学美根子

  神経研究の進歩, Feb. 2005, Invited

  
• Dual phases of migration of cerebellar granule cells guided by axonal and dendritic leading processes

  K Kawaji; H Umeshima; M Eiraku; T Hirano; M Kengaku

  MOLECULAR AND CELLULAR NEUROSCIENCE, Feb. 2004, Peer-reviewed

  
• Delta/Notch-like epidermal growth factor (EGF)-related receptor, a novel EGF-like ReDeat-cont ining protein T ryeted to dendrites of developing and adult central nervous system neurons

  M Eiraku; Y Hirata; H Takeshima; T Hirano; M Kengaku

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2002, Peer-reviewed

  

Misc.

• Regulation of cell fate by manipulation of dynamics of gene regulatory network

  樽本雄介; 杉野成一; 山内悠平; 石川雅人; 和穎文; 永樂元次; 望月敦史; 遊佐宏介

  日本ゲノム編集学会大会要旨集, 2024

  
• 発生過程における時空間制御機構 発生時計依存的な体内時計形成の試験管内再現 細胞時計と中枢時計

  田宮 寛之; 永樂 元次

  日本細胞生物学会大会講演要旨集, Jun. 2020

  
• 脳の発生とその異常 A.正常発生 幹細胞からの脳組織形成技術-ES細胞やiPS細胞から脳組織を分化させる技術の現状とその応用について

  田宮寛之; 田宮寛之; 田宮寛之; 永樂元次; 永樂元次

  Clinical Neuroscience, 2020

  
• in vitro分化誘導の原理 (特集 iPS細胞/ES細胞の生物学) -- (多能性の発揮)

  永楽 元次

  遺伝 : 生物の科学, Jan. 2014

  
• iPS細胞による網膜細胞治療

  高橋 政代; 万代 道子; 杉田 直; 大西 明志; 坂井 徳子; 鎌尾 浩行; 岡本 理志; 小坂田 文隆; 森永 千佳子; 山田 千佳子; 柴田 由美子; 寺田 基剛; 秋丸 裕司; 白井 博志; Assawachananont Juthaporn; 金子 兵; 孫 嘉南; 永楽 元次; 笹井 芳樹; 平見 恭彦; 栗本 康夫; 金村 星余; 西下 直樹; 郷 正博; 川真田 伸; 西田 明弘; 石田 和寛; 宮本 紀子; 広瀬 文隆; 亀田 隆範; 下園 正剛; 藤原 雅史; 大石 明生; 川越 直顕; 大音 壮太郎; 雨宮 かおり; 赤木 忠道; 秋田 穣; 池田 華子; 鈴木 拓也; 春田 雅俊; 秋元 正行; 本田 孔士; 山中 伸弥; 桐生 純一; 寺崎 浩子; Gage Fred H

  日本眼科学会雑誌, Mar. 2016

  
• 1D16 Modeling cell apoptosis for simulating three-dimensional multicellular morphogenesis

  OKUDA Satoru; INOUE Yasuhiro; ADACHI Taiji; EIRAKU Mototsugu

  The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2016

  
• P7-02 マウス及びヒト胚性幹細胞からの3次元分化培養網膜を用いた網膜神経節細胞からの神経突起伸長(神経の発生・再生,グリア,ポスター発表,組織化学のモーダルシフト,第56回日本組織細胞化学会総会・学術集会)

  前川 有紀; 大西 暁士; 松下 恵三; 小出 直史; 万代 道子; 鈴間 潔; 桑原 篤; 大曽根 親文; 中野 徳重; 永楽 元次; 北岡 隆; 高橋 政代

  日本組織細胞化学会総会プログラムおよび抄録集, 2015

  
• 器官をつくる―in vitro眼杯形成モデルと力学シミュレーションによる変形メカニズムの検証

  奥田覚; 永楽元次

  実験医学, 2015

  
• Self-organization of axial polarity, inside-out layer pattern, and species-specific progenitor dynamics in human ES cell-derived neocortex (vol 110, pg 20284, 2013)

  Taisuke Kadoshima; Hideya Sakaguchi; Tokushige Nakano; Mika Soen; Satoshi Ando; Mototsugu Eiraku; Yoshiki Sasai

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2014

  
• 3D07 In vitro experimental system for observation of cell cycles in optic-cup morphogenesis

  SUZUKI Kensuke; EIRAKU Mototsugu; SUNAGA Junko; SASAI Yoshiki; ADACHI Taiji

  バイオエンジニアリング講演会講演論文集, 08 Jan. 2013

  
• Self-formation of optic-cup morphogenesis and retinal tissue elasticity

  N. Takata; E. Sakakura; M. Kawada; M. Eiraku; Y. Sasai

  MOLECULAR BIOLOGY OF THE CELL, 2013

  
• 2F16 Modeling Cell Proliferation for Simulating Tissue Morphogenesis Using Reversible Network Reconnection Model

  OKUDA Satoru; INOUE Yasuhiro; Eiraku Mototsugu; SASAI Yoshiki; ADACHI Taiji

  The Proceedings of the Bioengineering Conference Annual Meeting of BED/JSME, 2013

  
• S021011 Reversible Network Reconnection Simulation of Effects of Apical Contractility on Curvatures of Growing Epithelia

  OKUDA Satoru; INOUE Yasuhiro; EIRAKU Mototsugu; SASAI Yoshiki; ADACHI Taiji

  The Proceedings of Mechanical Engineering Congress, Japan, 2013

  
• Self-organization of neural patterns and structures in 3D culture of ES cells

  Y. Sasai; M. Eiraku

  JOURNAL OF NEUROCHEMISTRY, Oct. 2012

  
• 8C41 Self-organized formation of optic cup in vitro

  EIRAKU Mototsugu

  バイオエンジニアリング講演会講演論文集, 06 Jan. 2012

  
• Large Deformation of Multicellular \nTissue during Morphogenesis Using Reversible Network Reconnection Model

  Satoru Okuda; Yasuhiro Inoue; Mototsugu Eiraku; Yoshiki Sasai; Taiji Adachi

  Exciting Biologies : Forces in Biology（2012.10.4－6．Dublin, Ireland）, 2012, Peer-reviewed

  
• Mathematical Model for Large Deformations \nof Multiple-cell Aggregate during Tissue Morphogenesis

  Satoru Okuda; Yasuhiro Inoue; Mototsugu Eiraku; Yoshiki Sasai; Taiji Adachi

  10th World Congress on Computational Mechanics（WCCM2012）（2012.7.8－13．Sao Paulo, Brazil）, 2012, Peer-reviewed

  
• Simulations of Large Deformation \nduring Tissue Morphogenesis Using Reversible Network Reconnection Model．

  Satoru Okuda; Yasuhiro Inoue; Mototsugu Eiraku; Yoshiki Sasai; Taiji Adachi

  日本生物物理学会第50 回年 会（2012.9.22－24．名古屋）, 2012, Peer-reviewed

  
• Three-dimensional Vertex Model \nfor Morphogenesis of Multiple-cell Tissue with Physical and Topological Consistency.

  Satoru Okuda; Yasuhiro Inoue; Mototsugu Eiraku; Yoshiki Sasai; Taiji Adachi

  CDB Symposium 2012 : Quantitative Developmental Biology, RIKEN Center for Developmental Biology（2012.3.26－28．Kobe）, 2012, Peer-reviewed

  
• Three-Dimensional Vertex Model \nfor Simulating Large Deformation of Cell Aggregates during Tissue Morphogenesis

  Satoru Okuda; Yasuhiro Inoue; Mototsugu Eiraku; Yoshiki Sasai; Taiji Adachi

  International Symposium on Cellular Mechanobiology（2012.3.16．Kyoto）, 2012, Peer-reviewed

  
• 形態形成過程における多細胞組織の大変形シミュレーショ ンのためのリバーシブル・ネットワーク・リコネクションモデル

  奥田覚; 井上康博; 永樂元次; 笹井芳樹; 安達泰治

  日本数理生物学会第22 回大会（2012.9.10 －12．岡山）．, 2012, Peer-reviewed

  
• 組織発生の形態形成過程における細胞の分裂と成長のモデル化

  奥田覚; 井上康博; 永樂元次; 笹井芳樹; 安達泰治

  日本機械学会第24 回バイオエンジニアリング部門講演会（2012.1.7－8．豊中）, 2012, Peer-reviewed

  
• Subregional specification of ES cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals

  Teruko Danjo; Mototsugu Eiraku; Keiko Muguruma; Kiichi Watanabe; Masako Kawada; Yuchio Yanagawa; John L. R. Rubenstein; Yoshiki Sasai

  NEUROSCIENCE RESEARCH, 2011

  
• Self-organizing optic-cup morphogenesis in three-dimensional culture

  Mototsugu Eiraku; Yoshiki Sasai

  NEUROSCIENCE RESEARCH, 2011

  
• J025021 Mathematical Insight into Modeling Morphological Development of Sheet-Like Multicellular Tissue

  OKUDA Satoru; INOUE Yasuhiro; EIRAKU Mototsugu; SASAI Yoshiki; ADACHI Taiji

  The Proceedings of Mechanical Engineering Congress, Japan, 2011

  
• シート状多細胞組織の形態発生に関する数理モデルの検討

  奥田 覚; 井上康博; 永樂元次; 笹井芳樹; 安達泰治

  日本機械学会2011 年度年次大会（2011.9.12-15 東京）, 2011, Peer-reviewed

  
• Self-organized formation of cortical neural tissue from embryonic stem cells

  Mototsugu Eiraku; Yoshiki Sasai

  NEUROSCIENCE RESEARCH, 2009

  
• Mechanisms of dendrite arborization of the cerebellar Purkinje cell

  Mineko Kengaku; Megumi Kaneko; Kazuto Fujishima; Mototsugu Eiraku; Tsutomu Hashikawa

  NEUROSCIENCE RESEARCH, 2008

  
• Control of neural differentiation from ES cell

  Mototsugu Eiraku; Yoshiki Sasai

  NEUROSCIENCE RESEARCH, 2008

  
• Contact-dependent regulation of dendrite and glial fiber arborization mediated by delta/notch-like EGF-related receptor

  M Kengaku; M Eiraku; K Fujishima; T Hirano

  JOURNAL OF NEUROCHEMISTRY, Feb. 2004

  
• 小脳か粒細胞の遊走と極性化を制御するPax6の機能

  見学美根子; 山崎崇生; 河路光介; 永楽元次; 平野丈夫; 大隅典子

  生化学, 25 Aug. 2000

  

Presentations

• Organogenesis in stem cell culture

  Eiraku Mototsugu

  APPW2025, 18 Mar. 2025

  
• 幹細胞培養における細胞外環境の制御とオルガノイド形成

  永樂元次

  日本分子生物学会年会, 29 Nov. 2024, Invited

  
• Organogenesis in stem cell culture

  Eiraku Mototsugu

  The 33rd Hot Spring Harbor International Symposium-Cutting-Edge Research and Technology in Stem Cells and Reprogramming-, 30 Oct. 2024, Invited

  
• Manipulation of stem cell differentiation to recapitulate human developmental processes in vitro

  Eiraku Mototsugu

  The 61st Annual Meeting of the Biophysical Society of Japan, 15 Nov. 2023, Invited

  
• Neural Development in Stem Cell Culture

  Eiraku Mototsugu

  International Symposium on Neural Development and Diseases, 16 Mar. 2023

  
• Neural Development in Stem Cell Culture

  Eiraku Mototsugu

  The 21st Takeda Science Foundation Symposium on Bioscience Towards Understanding Human Development and Evolution, 27 Jan. 2023, Invited

  
• 網羅的な遺伝子で集うデータに基づくヒト初期発生の遺伝子制御ネットワークの解明

  永樂元次

  第４５回日本分子生物学会年会, 02 Dec. 2022

  
• 多能性幹細胞からの機能的組織誘導

  永樂元次

  創立１００周年記念 第７４回日本生物工学会大会, 18 Oct. 2022, Invited

  
• Neural tissue development in stem cell culture

  Mototsugu Eiraku

  ISN-APSN 2022, 01 Sep. 2022, Invited

  
• Mechanical forces in morphogenesis

  Mototsugu Eiraku

  24th Biennial Meeting of the International Society for Developmental Neuroscience, 09 May 2022, Invited

  
• Neural Development in Stem Cell Culture

  EIRAKU MOTOTSUGU

  The International Symposium Development and Plasticity of Neural Systems, 16 Mar. 2022, Invited

  
• Neural Development in Stem Cell Culture

  EIRAKU MOTOTSUGU

  BDR Symposium, 02 Mar. 2022, Invited

  
• Challenges in Elucidating Life Phenomena by applying the Engineering-assisted Methods

  EIRAKU MOTOTSUGU

  The 44th Annual Meeting of the Molecular Biology Society of Japan, 03 Dec. 2021, Invited

  
• Functional tissue formation from pluripotent stem cells by multicellular autonomy

  EIRAKU MOTOTSUGU

  The 27th East Asia Joint Symposium, 28 Oct. 2021, Invited

  
• Self-organized formation of functional tissues from pluripotent stem cells

  永樂元次

  第93回大会「技術が切り拓く多彩な未来 -医療現場への道筋-」, 03 Sep. 2021, Invited

  
• 幹細胞からの機能的組織誘導

  永樂 元次

  2021第三回再生学異分野融合研究会, 25 Aug. 2021, Invited

  
• 幹細胞からの多細胞組織形成と機能の創発

  永樂元次

  公益財団法人 大隅基礎科学創成財団 2020年度 第6回 創発セミナー 再生の不思議と応用の可能性, 23 Mar. 2021, Invited

  
• "Functional 3D tissue formation by in vitro manipulation and cell autonomy"

  Eiraku M

  The 15th International Symposium of The Institute Network for Biomedical Sciences: Cutting Edge of Biomedical and Metabolic Sciences., 06 Nov. 2020, Invited

  
• 機能的な脳組織を幹細胞から作る：現時点の到達点と今後の課題

  永樂 元次

  千里ライフサイエンス新適塾 「脳はおもしろい」第27回会合, 07 Jan. 2020, Invited

  
• 幹細胞からの自己組織化による神経オルガノイド形成

  永樂 元次

  NEURO2019 Brains Science Takes Flight: Bridging the Mind and Life, 26 Jul. 2019, Invited

  
• 神経オルガノイド形成における種特異性の解析

  永樂 元次

  第46回 日本毒性学会学術年会, 27 Jun. 2019, Invited

  
• 神経オルガノイド形成における種特異性の解析

  永樂 元次

  第19回日本蛋白質科学会年会 第71回日本細胞生物学会大会合同年次大会, 24 Jun. 2019, Invited

  
• Functional 3D tissue formation by in vitro manipulation and multicellular autonomy

  Eiraku M

  State-of-the-Art 3D Tissue Culture & Organoids 2019, 19 Apr. 2019, Invited

  
• Self-organization of patterned functional tissues from pluripotent stem cells

  Mototsugu Eiraku

  119th International Titisee Conference:Tissue formation and regeneration: from molecules to models, 30 Mar. 2019, Invited

  
• 発生システムの試験管内構築と制御

  永樂 元次

  日本発生生物学会秋季シンポジウム2018, 24 Nov. 2018, Invited

  
• Self-organization of patterned tissues from mouse and human stem cells

  Mototsugu Eiraku

  EMBO Workshop :Molecular mechanisms of developmental and regenerative biology, 12 Nov. 2018, Invited

  
• 多能性幹細胞からの神経組織形成～海馬組織の再構成はできるか？～

  永樂 元次

  第27回 海馬と高次脳機能学会, 29 Sep. 2018, Invited

  
• Functional three-dimensional tissue formation by in vitro manipulation and multicellular autonomy

  Mototsugu Eiraku

  第56回日本生物物理学会年会, 16 Sep. 2018, Invited

  
• Self-organized formation of neural organoids from stem cells

  Mototsugu Eiraku

  第40回日本生物学的精神医学会・第61回日本神経化学会大会, 07 Sep. 2018, Invited

  
• 多細胞体の自己組織的なパターン形成および形態形成メカニズム

  永樂 元次

  Cell aggregation meeting 2018, 27 Jul. 2018, Invited

  
• 多細胞の自己組織化能を利用したin vitro での機能的立体組織の構築

  永樂 元次

  日本機械学会第３０回バイオエンジニアリング講演会, 15 Dec. 2017, Invited

  
• Self-organization of patterned tissues from mouse and human stem cells

  Mototsugu Eiraku

  Cold Spring Harbor Laboratory Symposium, 08 Dec. 2017, Invited

  
• 細胞の自己組織化能を利用したin vitroでの機能的立体組織の構築

  永樂 元次

  第３７回比較眼科学会年次大会, 30 Jul. 2017, Invited

  
• 多能性幹細胞からの神経組織形成

  永樂 元次

  日本バイオマテリアル学会シンポジウム2016, 21 Nov. 2016, Invited

  
• Self-organized formation of patterned tissues from embryonic stem cells

  Mototsugu Eiraku

  Engineering the embryo: beyond Systems Biology, 14 Nov. 2016, Invited

  
• Self-organized formation of tissue architectures from pluripotent stem cells

  Mototsugu Eiraku

  Society for Developmental Biology, 75th annual meeting International Society of Differentiation , 19th International Conference, 06 Aug. 2016, Invited

  
• 細胞の自己組織化能を利用した in vitro での機能的立体組織の構築

  永樂 元次

  第15回日本再生医療学会総会, 19 Mar. 2016, Invited

  
• Generation of complex tissue structure In stem cell culture.

  Mototsugu Eiraku

  CRTD/ISSCR International Symposium, 01 Feb. 2016, Invited

  
• Self-organized formation of complex tissues from stem cells

  Mototsugu Eiraku

  BMB2015 (第38回日本分子生物学会年会_第88回日本生化学会大会 合同大会）, 04 Dec. 2015, Invited

  
• Self-organized formation of complex tissues from stem cells

  Mototsugu Eiraku

  48th Annual Meeting of the Developmental Biologists, 05 Jun. 2015, Invited

  
• 細胞の自己組織化を利用したin vitroでの機能的立体組織の構築

  永樂 元次

  第29回日本医学会総会2015関西, 12 Apr. 2015, Invited

  
• Self-organized formation of complex tissues from stem cells

  Mototsugu Eiraku

  細胞機能と分子活性の多次元蛍光生体イメージング, 28 Jan. 2015, Invited

  
• Tissue intrinsic mechanisms underlying retinal neuroepithelial patterning and morphogenesis

  Mototsugu Eiraku

  第87回日本生化学会大会, 17 Oct. 2014, Invited

  
• 多能性幹細胞からの立体神経組織構築手法の確立及びその構築過程の解析

  永樂 元次

  Merk Bioscience Forum 2014, 01 Aug. 2014, Invited

  
• 幹細胞からの網膜組織の自己組織化とその応用への課題

  永樂 元次

  第118回日本眼科学会総会, 04 Apr. 2014, Invited

  

Books and Other Publications

• オルガノイド実験スタンダード : 決定版 : 開発者が磨いて深化した珠玉のプロトコール集

  佐藤, 俊朗; 武部, 貴則; 永樂, 元次

  羊土社, Apr. 2025

  Find Kyoto University's collection of books :

  
• オルガノイド研究 : 培養・作製、活用、臨床応用

  谷口, 英樹, Contributor

  エヌ・ティー・エス, Aug. 2024

  Find Kyoto University's collection of books :

  
• オルガノイド実験スタンダード : 決定版 : 開発者直伝!珠玉のプロトコール集

  佐藤, 俊朗; 武部, 貴則; 永樂, 元次

  羊土社, Apr. 2019

  Find Kyoto University's collection of books :

  

External funds: Kakenhi

• Interplay of developmental clock and extracellular environment in brain formation

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  影山 龍一郎

  From 01 Apr. 2021, To 31 Mar. 2022, Project Closed

  発生時計;神経発生;脳構築;神経幹細胞;細胞外環境;大脳構築

  https://kaken.nii.ac.jp/grant/KAKENHI-WRAPUP-21H00459/
• Understanding the molecular basis that defines species-specific developmental timing

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University;Institute of Physical and Chemical Research

  Mototsugu Eiraku

  From 30 Jun. 2016, To 31 Mar. 2021, Project Closed

  形態形成;多能性幹細胞;種特異的発生様式;神経発生;種特異的発生機構;オルガノイド;種特異的;自己組織化;種特異性;発生;種差;幹細胞;神経;発生時計;１細胞解析;網膜発生;遺伝子発現プロファイル;発生時間スケール;ヒト発生;発生時間;網膜;大脳;ヒトES細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-16H06485/
• Interplay of developmental clock and extracellular environment in brain formation

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Institute of Physical and Chemical Research;Kyoto University

  Ryoichiro Kageyama

  From 30 Jun. 2016, To 31 Mar. 2021, Project Closed

  脳構築;発生時計;神経幹細胞;神経発生;数理モデル;分節時計;細胞外環境;大脳構築

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-16H06479/
• Establishment of a new methodology for inducing early embryo-like structures from stem cells

  Grant-in-Aid for Scientific Research (B)

  Kyoto University;Institute of Physical and Chemical Research

  Mototsugu Eiraku

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  モルフォゲン;オルガノイド;幹細胞;自己組織化;局所シグナル制御;形態形成;初期発生;肢芽形成;発生制御;局所制御;パターン形成;イメージング;分化制御;器官発生

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H04799/
• Stress field estimation in three-dimensional optic-cup by image-based modeling

  Grant-in-Aid for Challenging Exploratory Research

  Institute of Physical and Chemical Research

  Satoru Okuda

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  三次元バーテックスモデル;器官形成;バイオメカニクス;３次元バーテックスモデル;バイオメカ二クス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K14534/
• 上皮組織の分化パターンと形態形成をつなぐ力学制御メカニズムの解明

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Institute of Physical and Chemical Research

  永樂 元次

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  形態形成;自己組織化;幹細胞;シミュレーション

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-26112723/
• Dorsal and ventral specification in optic cup derived from ES cells in vitro

  Grant-in-Aid for Young Scientists (A)

  The Institute of Physical and Chemical Research

  Mototsugu EIRAKU

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  パターン形成;自己組織化;幹細胞;組織の三次元形態;極性;ES細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24680037/
• 神経上皮組織の自己組織的な形態形成の基盤となる細胞骨格動態の解明

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  The Institute of Physical and Chemical Research

  永樂 元次

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  立体組織形成;自己組織化;形態形成;幹細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-24112527/
• Analysis of neural tissue development using ES cells culture system

  Grant-in-Aid for Young Scientists (B)

  The Institute of Physical and Chemical Research

  Mototsugu EIRAKU

  From 01 Apr. 2009, To 31 Mar. 2011, Project Closed

  ES細胞;形態形成;器官発生;試験管内再構築;神経発生;イメージング;組織形成;幹細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21700367/
• 細胞間シグナルによる中枢神経系ニューロン・グリア突起の分岐パターン制御機構

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  The Institute of Physical and Chemical Research

  見学 美根子

  From 01 Apr. 2005, To 31 Mar. 2006, Project Closed

  DNER;樹状突起;プルキンエ細胞;顆粒細胞;細胞間シグナル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17024062/
• 中枢神経系細胞における新型コロナウイルス持続感染機構の解析

  Grant-in-Aid for Scientific Research (C)

  Basic Section 49060:Virology-related

  Kyoto University

  村本 裕紀子

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  SARS-CoV-2;新型コロナウイルス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K07086/
• Development of a new culture system for human coronaviruses using organoids

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 49:Pathology, infection/immunology, and related fields

  Kyoto University

  野田 岳志

  From 30 Jun. 2022, To 31 Mar. 2024, Granted

  オルガノイド;コロナウイルス;インフルエンザウイルス;風邪コロナウイルス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19431/
• より生体に近いオルガノイド創出のための細胞外環境制御技術の開発

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  永樂 元次

  From 01 Apr. 2023, To 31 Mar. 2028, Granted

  オルガノイド;幹細胞;発生生物学;ECM

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23H04933/
• 嗅上皮オルガノイドを用いた嗅受容体遺伝子発現制御機構の解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 44020:Developmental biology-related

  Kyoto University

  永樂 元次

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  オルガノイド;嗅上皮

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02487/
• 領域研究「細胞外情報を統御するマルチモーダルECM」の統括と運営

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Institute of Physical and Chemical Research

  藤原 裕展

  From 01 Apr. 2023, To 31 Mar. 2028, Granted

  細胞外マトリックス;技術支援;研究資源共有化;若手支援;広報

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-23H04927/
• 嗅上皮オルガノイドを用いた嗅受容体遺伝子発現制御機構の解明

  Grant-in-Aid for Scientific Research (B)

  Basic Section 44020:Developmental biology-related

  Kyoto University

  永樂 元次

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  器官発生;オルガノイド;嗅上皮

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27180/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Chemical Basis of Life

  7107, Spring, Faculty of Engineering, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Chemical Biology

  7129, Fall, Faculty of Engineering, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Life and Medical Sciences, Adv.

  H665, Spring, Graduate School of Engineering, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Life and Medical Sciences

  H663, Spring, Graduate School of Engineering, 1.5
• From 01 Apr. 2023, To 31 Mar. 2024

  Chemical Biology

  7129, Fall, Faculty of Engineering, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Chemical Basis of Life

  7107, Spring, Faculty of Engineering, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Frontiers of Biology

  N477, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Life and Medical Sciences, Adv.

  H665, Spring, Graduate School of Engineering, 1.5
• From 01 Apr. 2023, To 31 Mar. 2024

  Life and Medical Sciences

  H663, Spring, Graduate School of Engineering, 1.5
• From 01 Apr. 2023, To 31 Mar. 2024

  Frontiers in the Field of Chemical Biology and Biological Chemistry

  H409, Fall, Graduate School of Engineering, 1.5
• From 01 Apr. 2022, To 31 Mar. 2023

  Life and Medical Sciences, Adv.

  H665, Spring, Graduate School of Engineering, 1.5
• From 01 Apr. 2022, To 31 Mar. 2023

  Chemical Biology

  7129, Fall, Faculty of Engineering, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Life and Medical Sciences

  H663, Spring, Graduate School of Engineering, 1.5
• From 01 Apr. 2022, To 31 Mar. 2023

  Frontiers of Biology

  N477, Spring, Institute for Liberal Arts and Sciences, 2
• From Apr. 2017, To Mar. 2018

  Frontier in Life Sciences

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Course in Multicellular Network

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Chemical Biology

  Fall, 工学部
• From Apr. 2018, To Mar. 2019

  Life and Medical Sciences

  Spring, 工学研究科
• From Apr. 2018, To Mar. 2019

  Life and Medical Sciences, Adv.

  Spring, 工学研究科
• From Apr. 2019, To Mar. 2020

  Chemical Biology

  Fall, 工学部
• From Apr. 2019, To Mar. 2020

  Life and Medical Sciences

  Spring, 工学研究科
• From Apr. 2019, To Mar. 2020

  Life and Medical Sciences, Adv.

  Spring, 工学研究科
• From Apr. 2020, To Mar. 2021

  Chemical Biology

  Fall, 工学部
• From Apr. 2020, To Mar. 2021

  Life and Medical Sciences

  Spring, 工学研究科
• From Apr. 2020, To Mar. 2021

  Life and Medical Sciences, Adv.

  Spring, 工学研究科
• From Apr. 2021, To Mar. 2022

  Chemical Biology

  Fall, 工学部
• From Apr. 2021, To Mar. 2022

  Introduction to Industrial Chemistry

  Spring, 工学部
• From Apr. 2021, To Mar. 2022

  Introduction to Industrial Chemistry

  Spring, 工学部
• From Apr. 2021, To Mar. 2022

  Introduction to Industrial Chemistry

  Spring, 工学部
• From Apr. 2021, To Mar. 2022

  Introduction to Industrial Chemistry

  Spring, 工学部
• From Apr. 2021, To Mar. 2022

  Life and Medical Sciences

  Spring, 工学研究科
• From Apr. 2021, To Mar. 2022

  Life and Medical Sciences, Adv.

  Spring, 工学研究科

Participation in PhD Defense

• Establishing Cerebral Organoid on a Chip Model for In Vitro Vascularization and Disease Modeling

  Maneesha Shaji, Graduate School of Engineering, Sub-chief Examiner

  23 May 2023

Part-time lecturer

• From 29 May 2023, To 29 May 2023

  国立大学法人神戸大学
• From 23 May 2022, To 23 May 2022

  国立大学法人神戸大学, 医学部
• From 01 Apr. 2022, To 30 Sep. 2022

  東京大学理学部

Administration

School management (title, position)

• From 01 Apr. 2022, To 31 Mar. 2024

  ヒトES細胞研究センター センター長
• From 01 Apr. 2020, To 31 Mar. 2022

  ヒトES細胞研究センター センター長

Faculty management (title, position)

• From 01 Apr. 2024

  iSAL 運営委員
• From 01 Apr. 2024

  医生物学研究所　研究支援室　共同利用機器ユニット
• From 01 Apr. 2024

  兼業・利益相反審査委員会　委員長
• From 01 Oct. 2023

  将来構想委員会　委員
• From 20 Jul. 2023

  学術委員会　委員
• From 01 Apr. 2023

  医の倫理委員会　委員
• From 01 Apr. 2022

  （医生物学研究所）予算委員会　委員
• From 01 Apr. 2022

  ウイルス・幹細胞システム医生物学共同研究拠点専門委員会　委員
• From 01 Apr. 2022

  ウイルス・幹細胞システム医生物学共同研究拠点運営委員会　委員
• From 01 Apr. 2022

  ヒトＥＳ細胞株樹立・分配事業検討委員会　委員
• From 01 Jul. 2021

  再生実験動物施設飼育室施設運営委員会 委員
• From 01 Oct. 2016

  化学物質管理委員会　委員
• From 01 Apr. 2018, To 05 Jan. 2024

  研究データ保全委員会
• From 01 Apr. 2021

  施設整備委員会
• From 01 Oct. 2016, To 31 Mar. 2021

  (旧再生研)予算委員会　委員
• From 01 Oct. 2016, To 30 Jun. 2021

  再生医科学動物実験専門委員会
• From 01 Apr. 2018, To 31 Mar. 2022

  再生医学・再生医療の先端融合的共同研究拠点運営委員会
• From 01 Apr. 2018, To 31 Mar. 2022

  再生医学・再生医療の先端融合的共同研究拠点専門委員会
• From 06 May 2021, To 31 Mar. 2022

  ウイルス・再生医科学研究所予算委員

Academic, Social Contribution

Academic Contribution

• JST創発的研究支援事業岡田パネル アドバイザー

  Other

  JST, From 2023, To Present

  
• JSTさきがけ「多細胞」領域アドバイザー

  Other

  JST, From 2019, To Present