Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, ゲノム動態研究部門 がん細胞生物学, 教授

Concurrent Affiliation

• Graduate School of Medicine, 医学研究科 放射線腫瘍学
• Graduate School of Biostudies, 生命科学研究科 Global Frontier in Life Science A
• Graduate School of Pharmaceutical Sciences, 薬学研究科 基礎物理化学特論Ⅱ

Academic Degree

• Mar. 1998

  M. S. in Graduate School of Science(Nagoya University)
• 28 Jun. 2002

  Ph. D. in Graduate School of Science (Nagoya University)

Academic Resume (Graduate Schools)

• Nagoya University, Graduate School of Science, Division of Biological Science, 修了

Academic Resume (Undergraduate School/Majors)

• Nagoya University, School of Science, Division of Biological Science, 卒業

High School

• High School

  愛知県立旭丘高等学校

Language of Instruction

• Japanese
• English

ID,URL

• ORCID ID

  0000-0001-7507-3173

• J-Global ID

  201401001067568642

Website(s) (URL(s))

• http://www.rbc.kyoto-u.ac.jp/cancer_biology

researchmap URL

• https://researchmap.jp/7000008435

Research

Research Topics, Overview of the research

• Research Topics

  1. Molecular mechanisms behind malignant progression and chemo- and radio-resistance of cancer cells under intratumoral microenvironments.
  2. Molecular mechanisms behind cellular adaptive response to extracellular microenvironments, such as hypoxia.

• Overview of the research

  Malignant solid tumors contain hypoxic regions due to uncontrolled proliferation of cancer cells and insufficient formation of a vascular network. Accumulating evidence has suggested that hypoxia-inducible factor 1 (HIF-1) functions in not only cellular adaptive response to hypoxia but also malignant progression and chemo- and radio-resistance of cancer cells. However, gene networks responsible for the activation of HIF-1 have not yet been fully elucidated, which makes it difficult to develop novel therapeutic strategies for cancers. We aim at identifying novel HIF-1-related and hypoxia-dependent gene networks and utilizing them as rational targets for cancer therapies.

Research Areas

• Life sciences, Molecular biology
• Life sciences, Cell biology
• Life sciences, Pathobiochemistry
• Life sciences, Radiology
• Life sciences, Genomics
• Life sciences, Tumor biology

Papers

• Intratumour oxidative hotspots provide a niche for cancer cell dissemination

  Yoshifumi Ueda; Shigeki Kiyonaka; Laura M. Selfors; Keisuke Inoue; Hiroshi Harada; Tomohiro Doura; Kunishige Onuma; Makoto Uchiyama; Ryuhei Kurogi; Yuji Yamada; Jiacheng H. Sun; Reiko Sakaguchi; Yuki Tado; Haruki Omatsu; Harufumi Suzuki; Mike Aoun; Takahiro Nakayama; Taketoshi Kajimoto; Tetsuya Yano; Rikard Holmdahl; Itaru Hamachi; Masahiro Inoue; Yasuo Mori; Nobuaki Takahashi

  Nature Cell Biology, 21 Feb. 2025, Peer-reviewed

  
• 2-oxoglutarate-dependent Dioxygenases (2-OGDDs) as Oxygen Sensors: Their Importance in Health and Disease

  Peter W T Lee; Minoru Kobayashi; Takakuni Dohkai; Itsuki Takahashi; Takumi Yoshida; Hiroshi Harada

  The Journal of Biochemistry, 16 Dec. 2024, Peer-reviewed, Invited, Last author, Corresponding author

  
• ZBTB7A forms a heterodimer with ZBTB2 and inhibits ZBTB2 homodimerization required for full activation of HIF-1

  Gouki Kambe; Minoru Kobayashi; Hiroshi Ishikita; Sho Koyasu; Ester M. Hammond; Hiroshi Harada

  Biochemical and Biophysical Research Communications, Dec. 2024, Peer-reviewed, Last author, Corresponding author

  
• 生物部会からの提言：増殖死と分裂死の定義について

  原田浩; 三浦雅彦; 稲波修

  放射線生物研究, Jun. 2024, Lead author, Corresponding author

  
• Click3D: Click reaction across deep tissues for whole-organ 3D fluorescence imaging

  Iori Tamura; Daichi M. Sakamoto; Bo Yi; Yutaro Saito; Naoki Yamada; Jumpei Morimoto; Yoichi Takakusagi; Masafumi Kuroda; Shimpei I. Kubota; Hiroyuki Yatabe; Minoru Kobayashi; Hiroshi Harada; Kazuki Tainaka; Shinsuke Sando

  Science Advances, 19 Jul. 2024, Peer-reviewed

  
• Teleocidin B-4, a PKC Activator, Upregulates Hypoxia-Inducible Factor 1 (HIF-1) Activity by Promoting the Accumulation of HIF-1α Protein via the PKCα/mTORC Signaling Pathway

  Shogo Iseki; Hiroaki Ikeda; Sayaka Kobayashi; Kazuhiro Irie; Hiroshi Harada; Hideaki Kakeya

  Journal of Natural Products, 05 Jun. 2024, Peer-reviewed

  
• Analysis on promotive effect of rocking culture on keratinocyte differentiation in 3-dimensional reconstitution human epidermis

  Mayuko Endo; Hirofumi Teshima; Kojin Kitadani; Kobayashi Minoru; Tokuji Tsuji; Hideki Tatsukawa; Hiroshi Harada; Kiyotaka Hitomi

  Bioscience, Biotechnology, and Biochemistry, 17 May 2024, Peer-reviewed

  
• HIF-dependent and independent mechanisms underlying chemoresistance of hypoxic cancer cells

  Peter Wai Tik LEE; Lina Rochelle KOSEKI; Takao HAITANI; Hiroshi; HARADA; Minoru KOBAYASHI

  Cancers, Apr. 2024, Peer-reviewed, Invited, Corresponding author

  
• Fast tumor imaging using pH-responsive aggregation of cyanine dyes with rapid clearance

  Huiying Mu; Shuai Shao; Bingquan Wu; Koji Miki; Minoru Kobayashi; Hiroshi Harada; Kouichi Ohe

  Sensors and Actuators B: Chemical, Aug. 2024, Peer-reviewed

  
• Hypoxia- and Postirradiation reoxygenation-induced HMHA1/ARHGAP45 expression contributes to cancer cell invasion in a HIF-dependent manner

  Peter W. T. Lee; Tatsuya Suwa; Minoru Kobayashi; Hui Yang; Lina R. Koseki; Satoshi Takeuchi; Christalle C. T. Chow; Takaaki Yasuhara; Hiroshi Harada

  British Journal of Cancer, 13 May 2024, Peer-reviewed, Last author, Corresponding author

  
• Whole-Body and Whole-Organ 3D Imaging of Hypoxia Using an Activatable Covalent Fluorescent Probe Compatible with Tissue Clearing

  Daichi M. Sakamoto; Iori Tamura; Bo Yi; Sho Hasegawa; Yutaro Saito; Naoki Yamada; Yoichi Takakusagi; Shimpei I. Kubota; Minoru Kobayashi; Hiroshi Harada; Kenjiro Hanaoka; Masayasu Taki; Masaomi Nangaku; Kazuki Tainaka; Shinsuke Sando

  ACS Nano, 01 Feb. 2024, Peer-reviewed

  
• Reductively convertible nickel phthalocyanine precursor as a biological thiol-responsive turn-on photoacoustic contrast agent

  Nogita K; Sugahara T; Miki K; Mu H; Kobayashi M; Harada H; Ohe K

  Chemical Communications, Feb. 2024, Peer-reviewed

  
• DDX5 enhances HIF‐1 activity by promoting the interaction of HIF‐1α with HIF‐1β and recruiting the resulting heterodimer to its target gene loci

  Yukari SHIRAI; Tatsuya SUWA; Minoru KOBAYASHI; Sho KOYASU; *Hiroshi HARADA

  Biol Cell, Feb. 2024, Peer-reviewed, Last author, Corresponding author

  
• AT workshop 2023 -A platform for discussing cutting-edge science in DNA damage signaling, repair, and human disorders-

  Takata M; Harada H

  Genes to Cells, Jun. 2023, Peer-reviewed, Last author

  
• ZBTB2 is recruited to a specific subset of HIF-1 target loci to facilitate full gene expression under hypoxia

  Chow CCT; Kobayashi M; Kambe G; *Harada H

  Journal of Molecular Biology, Aug. 2023, Peer-reviewed, Last author, Corresponding author

  
• Loss of ATF6α in a Human Carcinoma Cell Line Is Compensated not by Its Paralogue ATF6β but by Sustained Activation of the IRE1 and PERK Arms for Tumor Growth in Nude Mice

  Jin S; Jin B; Ishikawa T; Ninagawa S; Okada T; Koyasu S; Harada H; Mori K

  Molecular Biology of the Cell, Apr. 2023, Peer-reviewed

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• ZBTB2 links p53-deficiency to HIF-1-mediated hypoxia signaling for cancer aggressiveness

  Koyasu S; Horita S; Saito K; Kobayashi M; Ishikita H; Chow CCT; Kambe G; Nishikawa S; Menjyu T; Morinibu A; Okochi Y; Tabuchi Y; Onodera Y; Takeda N; Date H; Semenza GL; Hammond EM; *Harada H

  EMBO Rep, Jan. 2023, Peer-reviewed, Last author, Corresponding author

  
• Radiation-induced cell death and resultant tissue injury

  百海享洲; 武内智史; 王美惠; 宮長真広; 嶋貫悠; 小林稔; *原田浩

  医学のあゆみ, Oct. 2022, Invited, Last author, Corresponding author

  
• がんの放射線治療抵抗性

  髙橋樹; 神邊剛生; 白井友香理; *原田浩

  生体の科学, Apr. 2022, Invited, Last author, Corresponding author

  
• Imaging and Detecting Strategies for Hypoxic Cells; Lessons from Hypoxia Biology

  HARADA HIROSHI

  Transactions of Japanese Society for Medical and Biological Engineering, Jan. 2015, Invited

  
• 血漿蛋白質SPINK1を活用した悪性固形腫瘍内低酸素分画のモニタリングと放射線治療効果の増感

  諏訪達也; *原田浩

  放射線生物研究, Mar. 2022, Peer-reviewed, Invited, Last author, Corresponding author

  
• Proteolysis of a histone acetyl reader, ATAD2, induces chemoresistance of cancer cells under severe hypoxia by inhibiting cell cycle progression in S phase

  Haitani T; Kobayashi M; Koyasu S; Akamatsu S; Suwa T; Onodera Y; Nam JM; Nguyen PTL; Menju T; Date H; Ogawa O; *Harada H

  Cancer Letters, Apr. 2022, Peer-reviewed, Last author, Corresponding author

  
• SPINK1 as a plasma marker for tumor hypoxia and a therapeutic target for radiosensitization.

  Suwa T; Kobayashi M; Shirai Y; Nam JM; Tabuchi Y; Takeda N; Akamatsu S; Ogawa O; Mizowaki T; Hammond EM; Harada H

  JCI Insight, Jan. 2022, Peer-reviewed, Last author, Corresponding author

  
• Amphiphilic γ-cyclodextrin–fullerene complexes with photodynamic activity

  Miki K; Zhang ZD; Kaneko K; Kakiuchi Y; Kojima K; Enomoto A; Oe M; Nogita K; Murata Y; Harada H; Ohe K

  Mater. Adv, Mar. 2022

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• Design, synthesis, and target identification of new hypoxia-inducible factor 1 (HIF-1) inhibitors containing 1-alkyl-1H-pyrazole-3-carboxamide moiety

  Sakai M; Takahashi N; Ikeda H; Furutani Y; Higuchi S; Suzuki T; Dohmae N; Kobayashi S; Harada H; Kojima S; Matsuura T; Hattori A; Kakeya H

  Bioorg Med Chem, Sep. 2021, Peer-reviewed

  
• MMP2-activatable photoacoustic tumor imaging probes based on Al-and Si-naphthalocyanines.

  Miki K; Imaizumi N; Nogita K; Oe M; Mu H; Huo W; Harada H; Ohe K

  Bioconjug Chem, Aug. 2021, Peer-reviewed

  
• がん細胞の化学療法抵抗性を生み出す固形腫瘍内低酸素微小環境.

  灰谷崇夫; 小林稔; 原田浩

  実験医学（がん微小環境に１細胞レベルで挑む）, Jul. 2021, Invited, Last author, Corresponding author

  
• Tumor microenvironment and radioresistance

  Suwa T; Kobayashi M; Nam JM; Harada H

  Experimental & Molecular Medicine, Jul. 2021, Peer-reviewed, Invited, Last author, Corresponding author

  
• Polysulfide inhibits hypoxia-inducible factor activation in a mitochondria-dependent manner.

  Uba T; Matsuo Y; Sumi C; Shoji C; Nishi K; Kusunoki M; Harada H; Kimura H; Bono H; Hirota K

  Mitochondrion, Jun. 2021, Peer-reviewed

  
• Dual-stimuli-responsive probes for detection of ovarian cancer cells and quantification of both pH and enzyme activity.

  Huo W; Miki K; Tokunaga D; Mu H; Oe M; Harada H; Ohe K

  Bull Chem Soc Jpn, Jun. 2021, Peer-reviewed

  
• An Overview of the Recent Development of Anticancer Agents Targeting the HIF-1 Transcription Factor

  Shirai Y; Chow CCT; Kambe G; Suwa T; Kobayashi M; Takahashi I; Harada H; Nam JM

  Cancers, Jun. 2021, Peer-reviewed, Invited, Corresponding author

  
• Caspase cleavage releases a nuclear protein fragment that stimulates phospholipid scrambling at the plasma membrane

  Masahiro Maruoka; Panpan Zhang; Hiromi Mori; Eiichi Imanishi; Daniel M. Packwood; Hiroshi Harada; Hidetaka Kosako; Jun Suzuki

  Molecular Cell, Apr. 2021, Peer-reviewed

  
• pH-Activatable Cyanine Dyes for Selective Tumor Imaging Using Near-Infrared Fluorescence and Photoacoustic Modalities

  Huiying Mu; Koji Miki; Hiroshi Harada; Kouki Tanaka; Kohei Nogita; Kouichi Ohe

  ACS Sensors, 22 Jan. 2021, Peer-reviewed

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• Development of Antibody–Oligonucleotide Complexes for Targeting Exosomal MicroRNA

  Asako Yamayoshi; Shota Oyama; Yusuke Kishimoto; Ryo Konishi; Tsuyoshi Yamamoto; Akio Kobori; Hiroshi Harada; Eishi Ashihara; Hiroshi Sugiyama; Akira Murakami

  Pharmaceutics, 12 Jun. 2020, Peer-reviewed

  
• 酸素環境感知の基本メカニズムとがん

  小林稔 原田浩

  実験医学（酸素環境と臓器機能）, Jun. 2020, Invited, Last author, Corresponding author

  
• Space Radiation Biology for "Living in Space"

  Furukawa S; Nagamatsu A; Nenoi M; Fujimori A; Kakinuma S; Katsube T; WangB; Tsuruoka C; Shirai T; Nakamura AJ; Sakaue-Sawano A; Miyawaki A; Harada H; Kobayashi M; Kobayashi J; Kunieda T; Funayama T; Suzuki M; Miyamoto T; Hidema J; Yoshida Y; Takahashi A

  BioMed Res Int'l, Apr. 2020, Peer-reviewed

  
• 低酸素バイオロジーの創造と進展

  原田浩

  放射線生物研究, Mar. 2020, Peer-reviewed, Invited, Lead author, Last author, Corresponding author

  
• Disturbance in the Regulation of miR 17-92 Cluster on HIF-1-α Expression Contributes to Clinically Relevant Radioresistant Cells: An in Vitro Study

  Mehryar Habibi Roudkenar; Motoi Fukumoto; Amaneh Mohammadi Roushandeh; Youshikazu Kuwahra; Yusuke Uroshihara; Hiroshi Harada; Manabu Fukumoto

  Cytotechnology, Feb. 2020, Peer-reviewed

  
• IDH変異膠芽腫において14C酢酸集積は増加する 11C酢酸PETへの基礎的検討

  子安 翔; 志水 陽一; 佐賀 恒夫; 中本 裕士; 富樫 かおり; 原田 浩

  Japanese Journal of Diagnostic Imaging, Jan. 2020

  
• Increased 14C-acetate accumulation in IDH-mutated human glioblastoma: implications for detecting IDH-mutated glioblastoma with 11C-acetate PET imaging.

  Sho Koyasu; Yoichi Shimizu; Akiyo Morinibu; Tsuneo Saga; Yuji Nakamoto; Kaori Togashi; Hiroshi Harada

  Journal of neuro-oncology, Dec. 2019, Peer-reviewed

  
• Ubiquitin carboxyl-terminal hydrolase L1 promotes hypoxia-inducible factor 1-dependent tumor cell malignancy in spheroid models.

  Li X; Hattori A; Takahashi S; Goto Y; Harada H; Kakeya H

  Cancer science, Nov. 2019, Peer-reviewed

  
• HIF-1-Dependent Reprogramming of Glucose Metabolic Pathway of Cancer Cells and Its Therapeutic Significance.

  Ayako Nagao; Minoru Kobayashi; Sho Koyasu; Christalle C T Chow; Hiroshi Harada

  International journal of molecular sciences, 09 Jan. 2019, Peer-reviewed, Invited

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• 酸素ホメオスタシス制御機構の解明と放射線治療効果増強への展開

  原田 浩

  放影協ニュース, Oct. 2018, Invited

  
• pH-Responsive Cy5 dyes having nucleophilic substituents for molecular imaging

  Masahiro Oe; Koji Miki; Huiying Mu; Hiroshi Harada; Akiyo Morinibu; Kouichi Ohe

  TETRAHEDRON LETTERS, Aug. 2018, Peer-reviewed

  
• Suppression of mitochondrial oxygen metabolism mediated by the transcription factor HIF-1 alleviates propofol-induced cell toxicity.

  Sumi C; Okamoto A; Tanaka H; Kusunoki M; Shoji T; Uba T; Adachi T; Iwai T; Nishi K; Harada H; Bono H; Matsuo Y; Hirota K

  Scientific Reports, Jun. 2018, Peer-reviewed

  
• Regulatory mechanisms of hypoxia-inducible factor 1 activity: Two decades of knowledge.

  Sho Koyasu; Minoru Kobayashi; Yoko Goto; Masahiro Hiraoka; Hiroshi Harada

  Cancer science, Mar. 2018, Peer-reviewed, Invited

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• HIF-1 maintains a functional relationship between pancreatic cancer cells and stromal fibroblasts by upregulating expression and secretion of Sonic hedgehog

  Tomohiro Katagiri; Minoru Kobayashi; Michio Yoshimura; Akiyo Morinibu; Satoshi Itasaka; Masahiro Hiraoka; Hiroshi Harada

  Oncotarget, 2018, Peer-reviewed

  
• がん微小環境と低酸素 -HIF-1バイオロジーの視点から-.

  原田 浩

  月刊「細胞」, 2018, Peer-reviewed, Invited

  
• A circadian clock gene, PER2, activates HIF-1 as an effector molecule for recruitment of HIF-1 alpha to promoter regions of its downstream genes

  Minoru Kobayashi; Akiyo Morinibu; Sho Koyasu; Yoko Goto; Masahiro Hiraoka; Hiroshi Harada

  FEBS JOURNAL, Nov. 2017, Peer-reviewed

  
• The emerging roles of the ubiquitination/deubiquitination system in tumor radioresistance regarding DNA damage responses, cell cycle regulation, hypoxic responses, and antioxidant properties: Insight into the development of novel radiosensitizing strategies

  Yoko Goto; Sho Koyasu; Minoru Kobayashi; Hiroshi Harada

  MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, Oct. 2017, Peer-reviewed, Invited

  
• Metabolic reprogramming-mediated radioresistance

  後藤容子; 中島良太; 原田浩

  放射線生物研究, Sep. 2017, Peer-reviewed, Invited

  
• pH-Responsive near-infrared fluorescent cyanine dyes for molecular imaging based on pH sensing

  Koji Miki; Kentaro Kojima; Kazuaki Oride; Hiroshi Harada; Akiyo Morinibu; Kouichi Ohe

  CHEMICAL COMMUNICATIONS, Jul. 2017, Peer-reviewed

  
• UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization.

  Ryota Nakashima; Yoko Goto; Sho Koyasu; Minoru Kobayashi; Akiyo Morinibu; Michio Yoshimura; Masahiro Hiraoka; Ester M Hammond; Hiroshi Harada

  Scientific reports, 31 Jul. 2017, Peer-reviewed

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• HIF-1 and Cancer Cell Metabolism

  Hiroshi Harada

  Experimental Medicine, Jun. 2017, Invited

  
• HIF-1-mediated suppression of mitochondria electron transport chain function confers resistance to lidocaine-induced cell death

  Akihisa Okamoto; Chisato Sumi; Hiromasa Tanaka; Munenori Kusunoki; Teppei Iwai; Kenichiro Nishi; Yoshiyuki Matsuo; Hiroshi Harada; Keizo Takenaga; Hidemasa Bono; Kiichi Hirota

  SCIENTIFIC REPORTS, Jun. 2017, Peer-reviewed

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• がんの遠隔転移発生率を予測する新規バイオマーカーUCHL1-HIF-1に関する研究

  原田 浩; 吉村 通央; 小林 稔

  大和証券ヘルス財団研究業績集, Mar. 2017, Peer-reviewed

  
• 放射線治療後のがんの再発メカニズム

  原田 浩

  次世代がん治療, 2017, Peer-reviewed

  
• Hypoxia-inducible factor 1 promotes chemoresistance of lung cancer by inducing carbonic anhydrase IX expression

  Terumasa Sowa; Toshi Menju; Toyofumi F. Chen-Yoshikawa; Koji Takahashi; Shigeto Nishikawa; Takao Nakanishi; Kei Shikuma; Hideki Motoyama; Kyoko Hijiya; Akihiro Aoyama; Toshihiko Sato; Makoto Sonobe; Hiroshi Harada; Hiroshi Date

  CANCER MEDICINE, Jan. 2017, Peer-reviewed

  
• LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis

  Chan Joo Yeom; Lihua Zeng; Yoko Goto; Akiyo Morinibu; Yuxi Zhu; Kazumi Shinomiya; Minoru Kobayashi; Satoshi Itasaka; Michio Yoshimura; Cheol-Goo Hur; Hideaki Kakeya; Ester M. Hammond; Masahiro Hiraoka; Hiroshi Harada

  ONCOTARGET, Oct. 2016, Peer-reviewed

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• VHL-deficient renal cancer cells gain resistance to mitochondria-activating apoptosis inducers by activating AKT through the IGF1R-PI3K pathway

  Ryuji Yamaguchi; Hiroshi Harada; Kiichi Hirota

  TUMOR BIOLOGY, Oct. 2016, Peer-reviewed

  
• Cigarette smoke reversibly activates hypoxia-inducible factor 1 in a reactive oxygen species-dependent manner

  Hiroki Daijo; Yuma Hoshino; Shinichi Kai; Kengo Suzuki; Kenichiro Nishi; Yoshiyuki Matsuo; Hiroshi Harada; Kiichi Hirota

  SCIENTIFIC REPORTS, Sep. 2016, Peer-reviewed

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• Hypoxia-inducible factor 1-mediated characteristic features of cancer cells for tumor radioresistance

  Hiroshi Harada

  JOURNAL OF RADIATION RESEARCH, Aug. 2016, Invited

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• Evaluation of Tumor-associated Stroma and Its Relationship with Tumor Hypoxia Using Dynamic Contrast-enhanced CT and F-18 Misonidazole PET in Murine Tumor Models

  Sho Koyasu; Yoshihisa Tsuji; Hiroshi Harada; Yuji Nakamoto; Tomomi Nobashi; Hiroyuki Kimura; Kohei Sano; Koji Koizumi; Masatsugu Hamaji; Kaori Togashi

  RADIOLOGY, Mar. 2016, Peer-reviewed

  
• H3K9me3 facilitates hypoxia-induced p53-dependent apoptosis through repression of APAK

  M. M. Olcina; K. B. Leszczynska; J. M. Senra; N. F. Isa; H. Harada; E. M. Hammond

  ONCOGENE, Feb. 2016, Peer-reviewed

  
• 放射線によるシグナル伝達の変化

  原田 浩

  新版・放射線医科学, 2016, Invited

  
• Potent anti-tumor effects of EGFR-targeted hybrid peptide on mice bearing liver metastases

  Arong Gaowa; Tomohisa Horibe; Masayuki Kohno; Hiroshi Harada; Masahiro Hiraoka; Koji Kawakami

  CLINICAL & EXPERIMENTAL METASTASIS, Jan. 2016, Peer-reviewed

  
• PLK1 blockade enhances therapeutic effects of radiation by inducing cell cycle arrest at the mitotic phase

  Minoru Inoue; Michio Yoshimura; Minoru Kobayashi; Akiyo Morinibu; Satoshi Itasaka; Masahiro Hiraoka; Hiroshi Harada

  SCIENTIFIC REPORTS, Oct. 2015, Peer-reviewed

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• A novel method to visually determine the intracellular pH of xenografted tumor in vivo by utilizing fluorescent protein as an indicator

  Shotaro Tanaka; Hiroshi Harada; Masahiro Hiraoka

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2015, Peer-reviewed

  
• Aberrant IDH3 alpha expression promotes malignant tumor growth by inducing HIF-1-mediated metabolic reprogramming and angiogenesis

  L. Zeng; A. Morinibu; M. Kobayashi; Y. Zhu; X. Wang; Y. Goto; C. J. Yeom; T. Zhao; K. Hirota; K. Shinomiya; S. Itasaka; M. Yoshimura; G. Guo; E. M. Hammond; M. Hiraoka; H. Harada

  ONCOGENE, Sep. 2015, Peer-reviewed

  
• Midazolam inhibits the hypoxia-induced up-regulation of erythropoietin in the central nervous system

  Tomonori Matsuyama; Tomoharu Tanaka; Kenichiro Tatsumi; Hiroki Daijo; Shinichi Kai; Hiroshi Harada; Kazuhiko Fukuda

  EUROPEAN JOURNAL OF PHARMACOLOGY, Aug. 2015, Peer-reviewed

  
• Synthesis of Biocompatible Polysaccharide Analogues and Their Application to In Vivo Optical Tumor Imaging

  Koji Miki; Akinori Kimura; Tatsuhiro Inoue; Hideki Matsuoka; Hiroshi Harada; Masahiro Hiraoka; Kouichi Ohe

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Jun. 2015, Peer-reviewed

  
• Enhancement of anti-tumor activity of hybrid peptide in conjugation with carboxymethyl dextran via disulfide linkers

  Arong Gaowa; Tomohisa Horibe; Masayuki Kohno; Yasuhiko Tabata; Hiroshi Harada; Masahiro Hiraoka; Koji Kawakami

  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, May 2015, Peer-reviewed

  
• 低酸素シグナル

  後藤容子; 平岡真寛; 原田浩

  生体の化学, 2015, Invited

  
• UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1 alpha

  Yoko Goto; Lihua Zeng; Chan Joo Yeom; Yuxi Zhu; Akiyo Morinibu; Kazumi Shinomiya; Minoru Kobayashi; Kiichi Hirota; Satoshi Itasaka; Michio Yoshimura; Keiji Tanimoto; Masae Torii; Terumasa Sowa; Toshi Menju; Makoto Sonobe; Hideaki Kakeya; Masakazu Toi; Hiroshi Date; Ester M. Hammond; Masahiro Hiraoka; Hiroshi Harada

  Nature Communications, Jan. 2015, Peer-reviewed

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• Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIFI alpha/OATPs signaling axis

  Jason Boyang Wu; Chen Shao; Xiangyan Li; Changhong Shi; Qinlong Li; Peizhen Hu; Yi-Ting Chen; Xiaoliang Dou; Divya Sahu; Wei Li; Hiroshi Harada; Yi Zhang; Ruoxiang Wang; Haiyen E. Zhau; Leland W. K. Chung

  BIOMATERIALS, Sep. 2014, Peer-reviewed

  
• Sonication-Induced Formation of Size-Controlled Self-Assemblies of Amphiphilic Janus-Type Polymers as Optical Tumor-Imaging Agents

  Koji Miki; Hiroki Hashimoto; Tatsuhiro Inoue; Hideki Matsuoka; Hiroshi Harada; Masahiro Hiraoka; Kouichi Ohe

  SMALL, Aug. 2014, Peer-reviewed

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• Plastic induction of CD133(AC133)-positive cells in the microenvironment of glioblastoma spheroids

  Ken Ohnishi; Toshiaki Tani; Shin-Ichi Bando; Nobuo Kubota; Yoshihiro Fujii; Osamu Hatano; Hiroshi Harada

  INTERNATIONAL JOURNAL OF ONCOLOGY, Aug. 2014, Peer-reviewed

  
• Evaluation of intratumoral microenvironment with 18F-misonidazole PET and dynamic contrast enhanced CT in tumor-bearing mice models

  Koyasu Sho; Nakamoto Yuji; Harada Hiroshi; Kimura Hiroyuki; Sano Kohei; Koizumi Koji; Tsuji Yoshihisa; Nobashi Tomomi; Kurihara Kensuke; Togashi Kaori

  JOURNAL OF NUCLEAR MEDICINE, May 2014, Peer-reviewed

  
• Combination of hybrid peptide with biodegradable gelatin hydrogel for controlled release and enhancement of anti-tumor activity in vivo

  Arong Gaowa; Tomohisa Horibe; Masayuki Kohno; Keisuke Sato; Hiroshi Harada; Masahiro Hiraoka; Yasuhiko Tabata; Koji Kawakami

  JOURNAL OF CONTROLLED RELEASE, Feb. 2014, Peer-reviewed

  
• HIF-1-mediated metabolic reprogramming reduces ROS levels and facilitates the metastatic colonization of cancers in lungs

  Tao Zhao; Yuxi Zhu; Akiyo Morinibu; Minoru Kobayashi; Kazumi Shinomiya; Satoshi Itasaka; Michio Yoshimura; Guozheng Guo; Masahiro Hiraoka; Hiroshi Harada

  SCIENTIFIC REPORTS, Jan. 2014, Peer-reviewed

  
• Involvement of decreased hypoxia-inducible factor 1 activity and resultant G(1)-S cell cycle transition in radioresistance of perinecrotic tumor cells

  Y. Zhu; T. Zhao; S. Itasaka; L. Zeng; C. J. Yeom; K. Hirota; K. Suzuki; A. Morinibu; K. Shinomiya; G. Ou; M. Yoshimura; M. Hiraoka; H. Harada

  ONCOGENE, Apr. 2013, Peer-reviewed

  
• Interference in DNA Replication Can Cause Mitotic Chromosomal Breakage Unassociated with Double-Strand Breaks

  Mari Fujita; Hiroyuki Sasanuma; Kimiyo N. Yamamoto; Hiroshi Harada; Aya Kurosawa; Noritaka Adachi; Masato Omura; Masahiro Hiraoka; Shunichi Takeda; Kouji Hirota

  PLOS ONE, Apr. 2013, Peer-reviewed

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• 低酸素ストレスとHIF

  小林稔; 原田浩

  生化学. 85:187-195. 2013., 2013

  
• Microenvironment and Radiation Therapy

  Michio Yoshimura; Satoshi Itasaka; Hiroshi Harada; Masahiro Hiraoka

  BIOMED RESEARCH INTERNATIONAL, 2013, Peer-reviewed

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• Molecular basis of chemoradiotherapy and high-precision radiotherapy

  Michio Yoshimura; Masahiro Hiraoka; Hiroshi Harada

  Principles of Molecular Diagnostics and Personalized Cancer Medicine, 07 Dec. 2012

  
• Amphiphilic Brush-Like Copolymers Involving Hydrophobic Amino Acid- and Oligopeptide-Side Chains for Optical Tumor Imaging In Vivo

  Koji Miki; Katsuya Nakano; Hideki Matsuoka; Chan Joo Yeom; Hiroshi Harada; Masahiro Hiraoka; Kouichi Ohe

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Dec. 2012, Peer-reviewed

  
• がんの再発機構が示すPETイメージングの方向性

  原田浩

  Isotope news, 01 Nov. 2012

  
• Microenvironments and Cellular Characteristics in the Micro Tumor Cords of Malignant Solid Tumors

  Chan Joo Yeom; Yoko Goto; Yuxi Zhu; Masahiro Hiraoka; Hiroshi Harada

  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Nov. 2012, Peer-reviewed

  
• Contribution of hypoxia imaging to cancer radiation therapy : lessons from molecular radiation biology

  原田 浩; 後藤 容子; 井上 実

  臨床放射線, Apr. 2012

  
• Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels

  Hiroshi Harada; Masahiro Inoue; Satoshi Itasaka; Kiichi Hirota; Akiyo Morinibu; Kazumi Shinomiya; Lihua Zeng; Guangfei Ou; Yuxi Zhu; Michio Yoshimura; W. Gillies McKenna; Ruth J. Muschel; Masahiro Hiraoka

  NATURE COMMUNICATIONS, Apr. 2012, Peer-reviewed

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• Hydrogen Sulfide Inhibits Hypoxia- But Not Anoxia-Induced Hypoxia-Inducible Factor 1 Activation in a von Hippel-Lindau- and Mitochondria-Dependent Manner

  Shinichi Kai; Tomoharu Tanaka; Hiroki Daijo; Hiroshi Harada; Shun Kishimoto; Kengo Suzuki; Satoshi Takabuchi; Keizo Takenaga; Kazuhiko Fukuda; Kiichi Hirota

  ANTIOXIDANTS & REDOX SIGNALING, Feb. 2012, Peer-reviewed

  
• A biological mechanism behind the radioresistance of hypoxic tumor cells.

  Harada H; Itasaka S; Yoshimura M; Ogura M; Masunaga; Hiraoka M

  KURRI Progress Report, 2012

  
• HIFとその調節系

  原田浩

  日本臨牀増刊号：分子標的. 70:113-117. 2012., 2012

  
• 細胞内還元反応を活用した低酸素環境イメージング

  田邉一仁; 原田浩; 平岡真寛; 西本清一

  実験医学 30:89-95.2012., 2012

  
• Influence of Side Chain Length on Fluorescence Intensity of ROMP-Based Polymeric Nanoparticles and Their Tumor Specificity in In-Vivo Tumor Imaging

  Koji Miki; Kazuaki Oride; Akinori Kimura; Yoshiaki Kuramochi; Hideki Matsuoka; Hiroshi Harada; Masahiro Hiraoka; Kouichi Ohe

  SMALL, Dec. 2011, Peer-reviewed

  
• Effective encapsulation of a new cationic gadolinium chelate into apoferritin and its evaluation as an MRI contrast agent

  Akira Makino; Hiroshi Harada; Tomohisa Okada; Hiroyuki Kimura; Hiroo Amano; Hideo Saji; Masahiro Hiraoka; Shunsaku Kimura

  NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, Oct. 2011, Peer-reviewed

  
• In vivo Bioluminescence Imaging of Tumor Hypoxia Dynamics of Breast Cancer Brain Metastasis in a Mouse Model

  Debabrata Saha; Henry Dunn; Heling Zhou; Hiroshi Harada; Masahiro Hiraoka; Ralph P. Mason; Dawen Zhao

  JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, Oct. 2011, Peer-reviewed

  
• Fentanyl activates hypoxia-inducible factor 1 in neuronal SH-SY5Y cells and mice under non-hypoxic conditions in a mu-opioid receptor-dependent manner

  Hiroki Daijo; Shinichi Kai; Tomoharu Tanaka; Takuhiko Wakamatsu; Shun Kishimoto; Kengo Suzuki; Hiroshi Harada; Satoshi Takabuchi; Takehiko Adachi; Kazuhiko Fukuda; Kiichi Hirota

  EUROPEAN JOURNAL OF PHARMACOLOGY, Sep. 2011, Peer-reviewed

  
• How Can We Overcome Tumor Hypoxia in Radiation Therapy?

  Hiroshi Harada

  JOURNAL OF RADIATION RESEARCH, Sep. 2011, Peer-reviewed

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• Strategies to assess hypoxic/HIF-1-active cancer cells for the development of innovative radiation therapy

  Chan Joo Yeom; Lihua Zeng; Yuxi Zhu; Masahiro Hiraoka; Hiroshi Harada

  Cancers, Sep. 2011, Peer-reviewed

  
• Angiogenic roles of adrenomedullin through vascular endothelial growth factor induction

  Takakuni Maki; Masafumi Ihara; Youshi Fujita; Takuo Nambu; Hiroshi Harada; Hidefumi Ito; Kazuwa Nakao; Hidekazu Tomimoto; Ryosuke Takahashi

  NEUROREPORT, Jun. 2011, Peer-reviewed

  
• Angiogenic roles of adrenomedullin through vascular endothelial growth factor induction

  Takakuni Maki; Masafumi Ihara; Youshi Fujita; Takuo Nambu; Hiroshi Harada; Hidefumi Ito; Kazuwa Nakao; Hidekazu Tomimoto; Ryosuke Takahashi

  NEUROREPORT, Jun. 2011, Peer-reviewed

  
• Angiogenic and Vasoprotective Effects of Adrenomedullin on Prevention of Cognitive Decline After Chronic Cerebral Hypoperfusion in Mice

  Takakuni Maki; Masafumi Ihara; Youshi Fujita; Takuo Nambu; Kazutoshi Miyashita; Mahito Yamada; Kazuo Washida; Keiko Nishio; Hidefumi Ito; Hiroshi Harada; Hideki Yokoi; Hiroshi Arai; Hiroshi Itoh; Kazuwa Nakao; Ryosuke Takahashi; Hidekazu Tomimoto

  STROKE, Apr. 2011, Peer-reviewed

  
• HIF-1-Dependent Cellular Dynamics behind Tumor Recurrence after Radiation Therapy

  Harada H; Itasaka S; Shibuya K; Masunaga S; Hiraoka M

  Progress Report 2010, The Research Reactor Institute, Kyoto University, 2011

  
• AHR, a novel acute hypoxia-response sequence, drives reporter gene expression under hypoxia in vitro and in vivo.

  Mehmet Zeynel Cilek; Satoshi Hirohata; Omer Faruk Hatipoglu; Hiroko Ogawa; Toru Miyoshi; Junko Inagaki; Takashi Ohtsuki; Hiroshi Harada; Shigeshi Kamikawa; Shozo Kusachi; Yoshifumi Ninomiya

  Cell biology international, Jan. 2011, Peer-reviewed

  
• High-Contrast Fluorescence Imaging of Tumors In Vivo Using Nanoparticles of Amphiphilic Brush-Like Copolymers Produced by ROMP

  Koji Miki; Akinori Kimura; Kazuaki Oride; Yoshiaki Kuramochi; Hideki Matsuoka; Hiroshi Harada; Masahiro Hiraoka; Kouichi Ohe

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, Peer-reviewed

  
• Gene Therapy Strategy for Tumor Hypoxia.

  Harada H

  Targets in Gene Therapy. 11: 185-200. 2011., 2011, Peer-reviewed

  
• High-Contrast Fluorescence Imaging of Tumors In Vivo Using Nanoparticles of Amphiphilic Brush-Like Copolymers Produced by ROMP

  Koji Miki; Akinori Kimura; Kazuaki Oride; Yoshiaki Kuramochi; Hideki Matsuoka; Hiroshi Harada; Masahiro Hiraoka; Kouichi Ohe

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, Peer-reviewed

  
• がんに対する高精度放射線治療法の確立を見据えた低酸素イメージングの方向性 (特集 PET/CTと放射線治療計画)

  原田 浩; 平岡 眞寛

  PET journal, 2011

  
• Hypoxia-Inducible Factor 1 in Tumor Radioresistance

  Hiroshi Harada; Masahiro Hiraoka

  CURRENT SIGNAL TRANSDUCTION THERAPY, Sep. 2010, Peer-reviewed

  
• Synthesis and biological evaluation of indolyl chalcones as antitumor agents

  Dalip Kumar; N. Maruthi Kumar; Kanako Akamatsu; Eriko Kusaka; Hiroshi Harada; Takeo Ito

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jul. 2010, Peer-reviewed

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• Indolequinone-rhodol conjugate as a fluorescent probe for hypoxic cells: enzymatic activation and fluorescence properties

  Hirokazu Komatsu; Hiroshi Harada; Kazuhito Tanabe; Masahiro Hiraoka; Sei-ichi Nishimoto

  MEDCHEMCOMM, Jul. 2010, Peer-reviewed

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• A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells

  Tao Zhao; Hiroshi Harada; Yuji Teramura; Shotaro Tanaka; Satoshi Itasaka; Akiyo Morinibu; Kazumi Shinomiya; Yuxi Zhu; Hirofumi Hanaoka; Hiroo Iwata; Hideo Saji; Masahiro Hiraoka

  JOURNAL OF CONTROLLED RELEASE, May 2010, Peer-reviewed

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• Ring-opening metathesis polymerization-based synthesis of polymeric nanoparticles for enhanced tumor imaging in vivo: Synergistic effect of folate-receptor targeting and PEGylation

  Koji Miki; Kazuaki Oride; Satoru Inoue; Yoshiaki Kuramochi; Rati R. Nayak; Hideki Matsuoka; Hiroshi Harada; Masahiro Hiraoka; Kouichi Ohe

  BIOMATERIALS, Feb. 2010, Peer-reviewed

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• Optical Imaging of Intratumor HIF-1 Activity to Optimize Treatment Regimen for the Combination of a HIF-1 Inhibitor with Radiation Therapy.

  Harada H; Itasaka S; Shibuya K; Masunaga S; Hiraoka M

  KURRRI Progress Report 2009, 2010

  
• HIF-1-mediated tumor radioresistance and perspective on future radiation therapy

  原田 浩; 平岡 眞寛

  Japanese journal of cancer clinics, Dec. 2009

  
• Monitoring of Biological One-Electron Reduction by F-19 NMR Using Hypoxia Selective Activation of an F-19-Labeled Indolequinone Derivative

  Kazuhito Tanabe; Hiroshi Harada; Michiko Narazaki; Kazuo Tanaka; Kenichi Inafuku; Hirokazu Komatsu; Takeo Ito; Hisatsugu Yamada; Yoshiki Chujo; Tetsuya Matsuda; Masahiro Hiraoka; Sei-ichi Nishimoto

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 2009, Peer-reviewed

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• USEFULNESS OF HIF-1 IMAGING FOR DETERMINING OPTIMAL TIMING OF COMBINING BEVACIZUMAB AND RADIOTHERAPY

  Guangfei Ou; Satoshi Itasaka; Lihua Zeng; Keiko Shibuya; Junlin Yi; Hiroshi Harada; Masahiro Hiraoka

  INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, Oct. 2009, Peer-reviewed

  
• The intravenous anesthetics barbiturates inhibit hypoxia-inducible factor 1 activation

  Takuhiko Wakamatsu; Tomoharu Tanaka; Seiko Oda; Kenichiro Nishi; Hiroshi Harada; Hiroki Daijo; Satoshi Takabuchi; Shinichi Kai; Kazuhiko Fukuda; Kiichi Hirota

  EUROPEAN JOURNAL OF PHARMACOLOGY, Sep. 2009, Peer-reviewed

  
• 2nd Asian Congress of Radiation Research(アジア放射線研究会議)に参加して

  原田浩

  放射線生物研究, Sep. 2009

  
• The HIF-1-active microenvironment: An environmental target for cancer therapy

  Shinae Kizaka-Kondoh; Shotaro Tanaka; Hiroshi Harada; Masahiro Hiraoka

  ADVANCED DRUG DELIVERY REVIEWS, Jul. 2009, Peer-reviewed

  
• Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy

  H. Harada; S. Itasaka; Y. Zhu; L. Zeng; X. Xie; A. Morinibu; K. Shinomiya; M. Hiraoka

  BRITISH JOURNAL OF CANCER, Mar. 2009, Peer-reviewed

  
• Hypoxia-inducible Factor-1(HIF-1)による放射線治療後の腫瘍増殖亢進機構

  原田浩; 平岡真寛

  放射線生物研究, Mar. 2009

  
• Ring-Opening Metathesis Polymerization-Based Synthesis of ICG-Containing Amphiphilic Triblock Copolymers for in Vivo Tumor Imaging

  Koji Miki; Yoshiaki Kuramochi; Kazuaki Oride; Satoru Inoue; Hiroshi Harada; Masahiro Hiraoka; Kouichi Ohe

  BIOCONJUGATE CHEMISTRY, Mar. 2009, Peer-reviewed

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• The Akt/mTOR Pathway Assures the Synthesis of HIF-1 alpha Protein in a Glucose- and Reoxygenation-dependent Manner in Irradiated Tumors

  Hiroshi Harada; Satoshi Itasaka; Shinae Kizaka-Kondoh; Keiko Shibuya; Akiyo Morinibu; Kazumi Shinomiya; Masahiro Hiraoka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2009, Peer-reviewed

  
• Protein transduction domain-mediated delivery of anticancer proteins

  Hiroshi Harada; Masahiro Hiraoka

  Pharmaceutical Perspectives of Cancer Therapeutics, 2009, Peer-reviewed

  
• 低酸素がん細胞の光学イメージング.

  原田浩; 平岡真寛

  からだと酸素の事典., 2009

  
• HIF imaging is useful to determine the timing of combining Bevacizumab with radiation.

  Ou G; Itasaka S; Zeng L; Shibuya K; Yi J; Harada H; Hiraoka M

  Int J Radiat Oncol Biol Phys. 75:463-467. 2009., 2009, Peer-reviewed

  
• Radiolytic activation of a cytarabine prodrug possessing a 2-oxoalkyl group: one-electron reduction and cytotoxicity characteristics

  Nao Hirata; Yusuke Fujisawa; Kazuhito Tanabe; Hiroshi Harada; Masahiro Hiraoka; Sei-ichi Nishimoto

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2009, Peer-reviewed

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• Monitoring of Hypoxia-selective Enzymatic Reduction of Indolequinone derivative by 19F-NMR

  TANABE Kazuhito; KOMATSU Hirokazu; HARADA Hiroshi; HIRAOKA Masahiro; NISHIMOTO Sei‐ichi

  Photomedicine Photobiol, 2009, Peer-reviewed

  
• TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis

  Lihua Zeng; Guangfei Ou; Satoshi Itasaka; Hiroshi Harada; Xuejun Xie; Keiko Shibuya; Shinae Kizaka-Kondoh; Akiyo Morinibu; Kazumi Shinomiya; Masahiro Hiraoka

  CANCER SCIENCE, Nov. 2008, Peer-reviewed

  
• Diameter of tumor blood vessels is a good parameter to estimate HIF-1-active regions in solid tumors

  Hiroshi Harada; Xuejun Xie; Satoshi Itasaka; Lihua Zeng; Yuxi Zhu; Akiyo Morinibu; Kazumi Shinomiya; Masahiro Hiraoka

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2008, Peer-reviewed

  
• 分子イメージングによる放射線治療の新展開.

  原田浩; 板坂聡; 平岡真寛

  JSMI Report. 1: 5-8. 2008., 2008

  
• 新しい治療法評価への分子イメージングの応用・放射線治療の分子イメージング

  板坂聡; 原田浩; 近藤科江; 平岡真寛

  遺伝子医学MOOK. 9:279-283. 2008., 2008

  
• 腫瘍内HIF-1活性の光イメージング –その方法と重要性-.

  原田浩; 平岡真寛

  癌の臨床. 54:97-103. 2008., 2008

  
• Emission under hypoxia: One-electron reduction and fluorescence characteristics of an indolequinone-coumarin conjugate

  Kazuhito Tanabe; Nao Hirata; Hiroshi Harada; Masahiro Hiraoka; Sei-ichi Nishimoto

  CHEMBIOCHEM, Jan. 2008, Peer-reviewed

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• Emission under hypoxia: One-electron reduction and fluorescence characteristics of an indolequinone-coumarin conjugate

  Kazuhito Tanabe; Nao Hirata; Hiroshi Harada; Masahiro Hiraoka; Sei-ichi Nishimoto

  CHEMBIOCHEM, Jan. 2008, Peer-reviewed

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• Significance of HIF-1-active cells in angiogenesis and radioresistance

  H. Harada; S. Kizaka-Kondoh; G. Li; S. Itasaka; K. Shibuya; M. Inoue; M. Hiraoka

  ONCOGENE, Nov. 2007, Peer-reviewed

  
• The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts

  Hiroshi Harada; Shinae Kizaka-Kondoh; Satoshi Itasaka; Keiko Shibuya; Akiyo Morinibu; Kazumi Shinomiya; Masahiro Hiraoka

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2007, Peer-reviewed

  
• Adenovirus-mediated hypoxia-targeting cytosine deaminase gene therapy enhances radiotherapy in tumour xenografts

  J. Liu; H. Harada; M. Ogura; T. Shibata; M. Hiraoka

  BRITISH JOURNAL OF CANCER, Jun. 2007, Peer-reviewed

  
• Development of a novel fluorescent imaging probe for tumor hypoxia by use of a fusion protein with oxygen-dependent degradation domain of HIF-1α

  Shotaro Tanaka; Shinae Kizaka-Kondoh; Hiroshi Harada; Masahiro Hiraoka

  Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 2007, Peer-reviewed

  
• One-Electron Reduction Characteristics of Indolequinone-Coumarin Conjugate as Hypoxia Imaging Probe

  TANABE Kazuhito; HIRATA Nao; HARADA Hiroshi; HIRAOKA Masahiro; NISHIMOTO Sei‐ichi

  Photomedicine Photobiol, 2007, Peer-reviewed

  
• HIF-1を利用した腫瘍内低酸素がん細胞のイメージング・ターゲティング(2)

  近藤科江; 原田浩; 田中正太郎; 平岡真寛

  放射線科学, Dec. 2006

  
• HIF-1を利用した腫瘍内低酸素がん細胞のイメージング・ターゲティング(1)

  近藤科江; 原田浩; 田中正太郎; 平岡真寛

  放射線科学, Nov. 2006

  
• Mechanism of hypoxia-specific cytotoxicity of procaspase-3 fused with a VHL-mediated protein destruction motif of HIF-1 alpha containing Pro564

  Hiroshi Harada; Shinae Kizaka-Kondoh; Masahiro Hiraoka

  FEBS LETTERS, Oct. 2006, Peer-reviewed

  
• 『低酸素癌細胞』を標的とした癌のイメージング・ターゲティング (特集2 発光イメージングの突破力)

  近藤 科江; 原田 浩; 平岡 真寛

  バイオテクノロジージャーナル, Mar. 2006

  
• 低酸素を標的とした生体イメージング分子プローブの開発

  近藤科江; 原田浩; 平岡真寛

  未来医学. 21:32-37. 2006., 2006

  
• 腎細胞癌に対する腫瘍特異的遺伝子治療

  小倉昌和; 柴田徹; 原田浩; 平岡真寛

  日本臨牀・増刊号・分子腎臓病学. 888:672-677. 2006., 2006

  
• Antitumor protein therapy; application of the protein transduction domain to the development of a protein drug for cancer treatment.

  H. Harada; S. Kizaka-Kondoh; M. Hiraoka

  Breast cancer (Tokyo, Japan), 2006, Peer-reviewed

  
• Tumor-specific gene therapy strategy for renal cell carcinomas

  M. Ogura; T. Shibata; H. Harada; M. Hiraoka

  Nippon rinsho. Japanese journal of clinical medicine., 2006, Peer-reviewed

  
• Aminopeptidase N/CD13 targeting fluorescent probes: Synthesis and application to tumor cell imaging

  Z Zhang; H Harada; K Tanabe; H Hatta; M Hiraoka; S Nishimoto

  PEPTIDES, Nov. 2005, Peer-reviewed

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• Optical Imaging of Tumor Hypoxia and Evaluation of Efficacy of a Hypoxia-Targeting Drug in Living Animals

  Hiroshi Harada; Shinae Kizaka-Kondoh; Masahiro Hiraoka

  MOLECULAR IMAGING, Jul. 2005, Peer-reviewed

  
• A tumor-specific gene therapy strategy targeting dysregulation of the VHL/HIF pathway in renal cell carcinomas

  M Ogura; T Shibata; JL Yi; JY Liu; RJ Qu; H Harada; M Hiraoka

  CANCER SCIENCE, May 2005, Peer-reviewed

  
• Real-time imaging of hypoxia-inducible factor-1 activity in tumor xenografts

  JY Liu; RJ Qu; M Ogura; T Shibata; H Harada; M Hiraoka

  JOURNAL OF RADIATION RESEARCH, Mar. 2005, Peer-reviewed

  
• 革新的診断･治療へのアプローチ －膜透過性･標的特異性を有する融合タンパク質を用いたイメージング･ターゲティング－

  近藤科江; 原田浩; 平岡真寛

  Bio Clinica. 20: 53-58. 2005., 2005

  
• 基礎 癌治療におけるHIF-1とTumor Hypoxia

  近藤 科江; 平岡 真寛; 原田 浩

  Cancer frontier, 2005

  
• Tumor hypoxia: A target for selective cancer therapy

  S Kizaka-Kondoh; M Inoue; H Harada; M Hiraoka

  CANCER SCIENCE, Dec. 2003, Peer-reviewed

  
• Antitumor effect of TAT-oxygen-dependent degradation-caspase-3 fusion protein specifically stabilized and activated in hypoxic tumor cells

  H Harada; M Hiraoka; S Kizaka-Kondoh

  CANCER RESEARCH, Apr. 2002, Peer-reviewed

  

Misc.

• The Mechanism Underlying HIF-1-mediated Tumor Radioresistance

  HARADA Hiroshi; ITASAKA Satoshi; KONDOH Shinae; SHIBUYA Keiko; HIRAOKA Masahiro

  The Japan Radiation Research Society Annual Meeting Abstracts, 2008

  
• 放射線照射後の腫瘍内HIF-1活性のダイナミクス

  原田 浩; 板坂 聡; 近藤 科江; 澁谷 景子; 平岡 眞寛

  日本放射線影響学会大会講演要旨集, Nov. 2007

  
• Optical Imaging of Cancer 腫瘍内低酸素がん細胞のイメージング・ターゲティング(Optical Imaging of Cancer Imaging and targeting of HIF-1-active hypoxic tumor cells)

  近藤 科江; 田中 正太郎; 曾 麗華; 原田 浩; 板坂 聡; 渋谷 景子; 平岡 眞寛

  日本癌学会総会記事, Aug. 2007

  
• Postirradiation Dynamics of HIF-1 Activity in Tumor Xenografts

  HARADA Hiroshi; ITASAKA Satoshi; KONDOH Shinae; SHIBUYA Keiko; HIRAOKA Masahiro

  The Japan Radiation Research Society Annual Meeting Abstracts, 2007

  
• 生体レベルで発がんプロセスをモニターする遺伝子改変マウスの構築と解析

  近藤 科江; 近藤 玄; 山田 秀一; 原田 浩; 平岡 眞寛

  日本癌学会総会記事, Sep. 2006

  
• [Hypoxic stress and HIF].

  Minoru Kobayashi; Hiroshi Harada

  Seikagaku. The Journal of Japanese Biochemical Society, 2013

  
• Evaluation of tumour hypoxia and cancer stroma using F-18-misonidazole PET and dynamic contrast enhanced CT in tumor-bearing mice models

  S. Koyasu; Y. Nakamoto; H. Harada; Y. Tsuji; H. Kimura; K. Sano; T. Nobashi; K. Togashi

  EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, Oct. 2014

  
• Optical imaging of HIF-1 activity in solid tumor: the method and importance

  原田 浩; 平岡 眞寛

  Japanese journal of cancer clinics, 2008

  
• HIF-1 alpha expression correlated with glycolytic metabolism, and affected on drug resistance in lung cancer

  T. Sowa; T. Menju; F. Chen; T. Nakanishi; S. Neri; H. Cho; K. Shikuma; H. Motoyama; K. Hijiya; A. Aoyama; T. Sato; M. Sonobe; H. Harada; H. Date

  EUROPEAN JOURNAL OF CANCER, Sep. 2015

  
• UCHL1-HIF-1 axis-mediated antioxidant property of cancer cells as a therapeutic target for radiosensitization

  Ryota Nakashima; Yoko Goto; Sho Koyasu; Minoru Kobayashi; Michio Yoshimura; Masahiro Hiraoka; Hiroshi Harada

  CANCER SCIENCE, Jan. 2018

  
• UCHL1-HIF-1活性化経路を標的とした分子標的抗がん剤開発研究

  LI Xuebing; 服部明; 後藤容子; 森鳰章代; 平岡眞寛; 原田浩; 原田浩; 原田浩; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2017

  
• ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair.

  Masataka Tsuda; Kosai Cho; Masato Ooka; Naoto Shimizu; Reiko Watanabe; Akira Yasui; Yuka Nakazawa; Tomoo Ogi; Hiroshi Harada; Keli Agama; Jun Nakamura; Ryuta Asada; Haruna Fujiike; Tetsushi Sakuma; Takashi Yamamoto; Junko Murai; Masahiro Hiraoka; Kaoru Koike; Yves Pommier; Shunichi Takeda; Kouji Hirota

  PloS one, 2017

  Access this misc :

  
• 造影ダイナミックCTとフッ素18フルオロミソニダゾール陽電子放出断層撮像法を用いた、腫瘍間質の評価および腫瘍低酸素との関連性の評価

  子安 翔; 辻 喜久; 原田 浩; 中本 裕士; 野橋 智美; 木村 寛之; 佐野 紘平; 小泉 幸司; 濱路 政嗣; 富樫 かおり

  JSMI Report, Dec. 2016

  
• 造影ダイナミックCTとフッ素18フルオロミソニダゾール陽電子放出断層撮像法を用いた、腫瘍間質の評価および腫瘍低酸素との関連性の評価

  子安 翔; 辻 喜久; 原田 浩; 中本 裕士; 野橋 智美; 木村 寛之; 佐野 紘平; 小泉 幸司; 濱路 政嗣; 富樫 かおり

  核医学, Oct. 2016

  
• 造影ダイナミックCTとフッ素¹⁸フルオロミソニダゾール陽電子放出断層撮像法を用いた,腫瘍間質の評価および腫瘍低酸素との関連性の評価

  子安翔; 辻喜久; 原田浩; 中本裕士; 野橋智美; 木村寛之; 佐野紘平; 小泉幸司; 濱路政嗣; 富樫かおり

  核医学(Web), 2016

  
• Genetic Screening of Upstream Activators of Hypoxia-inducible Factor 1 for the Devrlopment of Novel Anti-cancer Strategies

  Harada H; Masunaga S; Hiraoka M

  Progress Report 2014, The Research Reactor Institute, Kyoto University, 2015

  
• チオール化カルボキシメチルデキストランとのS-S結合によるEGFR2R-lyticハイブリッドペプチドの抗腫瘍効果の増強

  阿栄 高娃; 堀部 智久; 河野 雅之; 田畑 泰彦; 原田 浩; 平岡 眞寛; 川上 浩司

  「第30回日本DDS学会学術集会」2014年7月30日-31日, 東京, Jul. 2014

  
• DH3αOverexpression Promotes Malignant Tumor Growth by Inducing HIF・1Activity

  Harada H; Masunaga S; Hiraoka M

  Progress Report 2013, The Research Reactor Institute, Kyoto University, 2014

  
• ゼラチンハイドロゲルを用いたEGFR2R-lyticハイブリッドペプチドの徐放性注射製剤の開発

  阿栄 高娃; 堀部 智久; 河野 雅之; 佐藤 圭祐; 田畑 泰彦; 原田 浩; 平岡 眞寛; 川上 浩司

  「第29回日本DDS学会」 2013年7月4日―5日, 京都, Jul. 2013

  
• Hypoxia-mediated cancer imaging by a novel class of near-infrared (NIR) heptamethine cyanine dyes

  Jason Boyang Wu; Chen Shao; Xiangyan Li; Peizhen Hu; Yi-Ting Chen; Xiaoliang Dou; Divya Sahu; Wei Li; Hiroshi Harada; Ruoxiang Wang; Haiyen E. Zhau; Leland W. K. Chung

  CANCER RESEARCH, Apr. 2013

  
• IDH3はHIF-1alphaを安定化して腫瘍増殖を亢進する

  小林 稔; 曽 麗華; 後藤 容子; 井上 実; 板坂 聡; 吉村 通央; 原田 浩; 平岡 真寛

  2013

  
• Upstream Activators of HIF-1 as Targets for Radiosensitization

  Harada H; Masunaga S; Hiraoka M

  Progress Report 2012, The Research Reactor Institute, Kyoto University, 2013

  
• Treatment regimen determines whether a HIF-1 inhibitor enhances or inhibits the effect of radiation therapy

  H. Harada; S. Itasaka; K. Shibuya; M. Hiraoka

  EJC SUPPLEMENTS, Sep. 2009

  
• Anti-tumor effects of TAT-ODD caspase 3 fusion protein specifically stabilized in hypoxic tumor cells.

  S Kizaka-Kondoh; H Harada; M Hiraoka

  CLINICAL CANCER RESEARCH, Nov. 2001

  

Presentations

• The Impact of Hypoxia on Tumor Recurrence and Genome Instability

  Hiroshi HARADA

  UCLA-KU-AS Asia-Pan Pacific Meeting, 15 May 2025, Invited

  
• The Importance of Hypoxia in Tumor Recurrence and Cancer Genome Heterogeneity

  Hiroshi HARADA

  Seoul National University Seminar, 27 Mar. 2025, Invited

  
• がんの低酸素応答機構の理解と利用

  原田浩

  第14回生理化学ユニットシンポジウム, 20 Dec. 2024, Invited

  
• がんを知り尽くそう

  原田浩

  Qカフェ, 13 Dec. 2024, Invited

  
• My interactions with NTU people and my research

  Hiroshi HARADA

  Japan-Taiwan Biotech Association annual symposium, 30 Nov. 2024, Invited

  
• 科学者を目指すために

  原田浩

  窮理養心塾（紀の川市少年少女発明クラブ）, 16 Nov. 2024, Invited

  
• 低酸素バイオロジーで迫るがんの素顔

  原田浩

  令和6年度 第6回TBRCセミナー, 03 Oct. 2024, Invited

  
• Functional importance of the interplay between “hypoxia signaling” and “DNA damage response”

  Hiroshi HARADA

  The 83rd Annual Meeting of Japanese Cancer Association, 20 Sep. 2024, Invited

  
• 低酸素刺激によるがんのクローン進化

  原田浩

  第28回癌治療増感研究会, 29 Jun. 2024

  
• ZBTB2はp53変異型がん細胞の悪性形質をHIF-1依存的に誘導する

  原田浩

  第28回日本がん分子標的治療学会学術集会, 20 Jun. 2024

  
• 酸素生物学で迫るがんの素顔

  原田浩

  信濃町Feather研究会, 26 Mar. 2024, Invited

  
• 腫瘍組織内の低酸素とは

  原田浩

  第１回統合放射線科学リトリート, 06 Mar. 2024

  
• がんと放射線： 研究の深化と治療法の進化

  原田浩

  桃山オープンセミナー, 2024, Invited

  
• 低酸素バイオロジーを基盤とする放射線腫瘍生物学研究

  原田浩

  日本放射線影響学会 第66回学術大会, 08 Nov. 2023, Invited

  
• ZBTB2, as a link between HIF-1-mediated hypoxia response and p53 deficiency in tumor growth

  Hiroshi HARADA

  isDDRHD2023, 03 Nov. 2023, Invited

  
• 腫瘍組織内の慢性・急性低酸素環境を模倣する低酸素培養法の考察

  原田浩

  第96回日本生化学会, 01 Nov. 2023, Invited

  
• 酸素生物学で迫るがん細胞の特性

  原田浩

  次世代を担う若手のための フィジカル・ファーマフォーラム, 01 Sep. 2023, Invited

  
• 低酸素生物学を基盤にした 「がんの放射線抵抗性の理解と克服」に関する研究

  原田浩

  第79回放射線科学研究会, 31 Jul. 2023, Invited

  
• がんと酸素

  原田浩

  関東SSH, 26 Jul. 2023, Invited

  
• Radioresistance of hypoxic tumor cells -importance of tumor hypoxia-

  Hiroshi HARADA

  UCLA- Kyoto University Online seminar series., 04 Jul. 2023, Invited

  
• 腫瘍内低酸素を指標とした“がんの早期発見”と“予後予測”を 可能にする血漿バイオマーカー

  原田浩

  AMED膵がんワークショップ, 17 Jun. 2023

  
• Tumor hypoxia as a predictor for radiation therapy

  Hiroshi HARADA

  Annual Meeting of European Society for Radiotherapy and Oncology 2023 (ESTRO2023), 15 May 2023, Invited

  
• 変異KRAS分子標的薬と放射線治療の併用効果に対する 腫瘍内酸素環境の影響の考察

  原田浩

  日本癌学会シンポジウム・KRAS分子標的薬の開発, 26 Apr. 2023, Invited

  
• 腫瘍低酸素と放射線抵抗性

  原田浩

  第13回日本放射線腫瘍学会・放射線生物学セミナー, 18 Feb. 2023, Invited

  
• Hypoxic tumor cells: their dynamics during tumor growth and involvement in recurrence after radiation therapy.

  Hiroshi HARADA

  Sussex-Japan Genome Stability Meeting, 19 Jan. 2023, Invited

  
• Radioresistance of Hypoxic Tumor Cells.

  Hiroshi HARADA

  The 13th International Symposium on the DNA Damage Response & Human Disease 2022 (isDDRHD-2022), 10 Dec. 2022, Invited

  
• Radioresistance of hypoxic tumor cells; lessons from hypoxia and HIF-1 biology.

  Hiroshi HARADA

  The 5th Asian Congress of Radiation Research, 18 Nov. 2022, Invited

  
• The nature of cancers; what we revealed through hypoxia biology

  原田浩

  名古屋大学大学院創薬科学研究科 第154回創薬科学セミナー, 30 Aug. 2022, Invited

  
• 固形腫瘍内の不均一な酸素環境におけるがん細胞の動態

  原田浩

  第31回 日本がん転移学会学術集会・総会, 07 Jul. 2022, Invited

  
• Function and mechanisms of action of a novel activator of HIF-1

  原田浩

  第27回癌治療増感研究会, 23 Apr. 2022, Invited

  
• 酸素生物学と放射線腫瘍学の接点

  原田浩

  日本量子医科学会第1回学術総会, 10 Dec. 2021, Invited

  
• 高線量放射線照射後の腫瘍内酸素環境の変化に基づく分割照射法の再考

  原田浩

  第34回日本放射線腫瘍学会, 15 Nov. 2021, Invited

  
• HIFシグナルが加速する悪性固形腫瘍内の細胞社会ダイバーシティー

  原田浩

  第94回日本生化学学会, 04 Nov. 2021, Invited

  
• 低酸素バイオロジーの視点で見るハイパーサーミアによる放射線増感

  原田浩

  第38回日本ハイパーサーミア学会, 03 Sep. 2021, Invited

  
• 低酸素バイオロジーで迫る「がんの悪性形質と治療抵抗性」

  原田浩

  リプロセル学術講演会, 20 Apr. 2021, Invited

  
• Functional and mechanistic linkage betweenp53-deficiency to HIF-1-mediated hypoxia signaling in cancers.

  Harada H

  The 43rd. MBSJ, 03 Dec. 2020, Invited

  
• 低酸素と放射線の関わり

  原田浩

  第10回日本放射線腫瘍学会（JASTRO）放射線生物学セミナー, 16 Feb. 2020, Invited

  
• 放射線腫瘍学における低酸素バイオロジー.

  原田浩

  第49回. 京都放射線腫瘍研究会, 15 Feb. 2020, Invited

  
• A link between activation of HIF-1 and defect in p53 in malignantprogression of cancers.

  Harada H

  International Seminar on Stress Medicine and PrecisionHealthcare; from Hypoxia and DNA Damage Response to Therapeutic Intervention, 30 Dec. 2019, Invited

  
• 新規HIF-1活性化因子の発現スクリーニングで明らかになったHIF-1活性制御機構

  原田浩

  第42回日本分子生物学会年会, 06 Dec. 2019, Invited

  
• Radioresistance of hypoxic tumor cells; Lessons from hypoxiaand HIF-1 biology.

  Harada H

  The 3rd isRTB., 28 Nov. 2019, Invited

  
• 低酸素・腫瘍生物学研究で迫る癌治療増感.

  原田浩

  日本放射線腫瘍学会第32回学術大会. 名古屋, 21 Nov. 2019, Invited

  
• 放射線治療効果の増強につなげる腫瘍生物学・低酸素生物学研究

  原田浩

  第57回日本癌治療学会学術集会, 26 Oct. 2019, Invited

  
• Tumor hypoxia; its influences on malignant progression and therapyresistance of cancer cells

  Harada H

  Special Seminar in Kobe University GraduateSchool of Medicine, 09 Oct. 2019, Invited

  
• A link between HIF-1 and defect in p53 under hypoxic stress

  Harada H

  The 78th Annual Meeting ofJapanese Cancer Association, 26 Sep. 2019, Invited

  
• 低酸素がん細胞の治療抵抗性と再発を担う能動的休眠制御

  原田浩

  第92回日本生化学会大会, 18 Sep. 2019, Invited

  
• Radioresistance of hypoxic tumor cells; Lessons from hypoxia& HIF-1 biology and beyond

  Harada H

  The 16th International Congress of RadiationResearch 2019 (ICRR2019)., 29 Aug. 2019, Invited

  
• がん抑制機構と低酸素応答機構をつなぐ新規遺伝子の同定と活用

  原田浩

  第21回京都大学大学院生命科学研究科シンポジウム, 04 Jul. 2019, Invited

  
• 分子腫瘍学・構造生物学・理論化学・臨床医学の融合によるがんの悪性進展制御因子に対するドラッグデザイン研究

  原田 浩

  日本医療研究開発機構（AMED) 平成30年度 創薬基盤推進研究事業公開シンポジウム, 28 Jan. 2019, Invited

  
• Functions of HIF-1 in tumor hypoxia and beyond

  Hiroshi Harada

  Bio-Group Symposium 2018. Taipei., 23 Dec. 2018, Invited

  
• p53変異型腫瘍の悪性進展を抑制するPPI阻害剤創製に向けた試み

  原田 浩

  第1回モダリティ創薬デザイン研究会シンポジウム, 26 Nov. 2018, Invited

  
• 低酸素/HIF-1バイオロジーを基軸とする放射線腫瘍生物学研究 -放生研の研究プラットフォームを交えて-.

  原田 浩

  第61回日本放射線影響学会., 07 Nov. 2018, Invited

  
• 腫瘍低酸素に係る基礎研究と臨床応用

  原田 浩

  腫瘍低酸素に係る基礎研究と臨床応用, 13 Oct. 2018, Invited

  
• 臓器間のDNA損傷耐用能の違いから迫る”宇宙放射線克服に向けた基盤構築

  Hiroshi Harada

  日本宇宙生物科学会第32回大会, 23 Sep. 2018, Invited

  
• Function of HIF-1 in tumor hypoxia and beyond

  Hiroshi Harada

  東北大学大学院薬学研究科セミナー, 21 Sep. 2018, Invited

  
• Radioresistance of hypoxic tumor cells

  Hiroshi Harada

  Radiation Biology School, Hokkaido Summer Institute 2018, 03 Aug. 2018, Invited

  
• 悪性固形腫瘍内低酸素微小環境と放射線感受性

  原田 浩

  AMED創薬基盤推進研究事業 CMB育成事業〜別府リトリート合宿, 27 Jul. 2018, Invited

  
• HIF-1 and Tumor Progression

  Hiroshi Harada

  24th Congress of International Union of Biochemistry and Molecular Biology, 05 Jun. 2018, Invited

  
• HIF-1 in tumor hypoxia and beyond

  原田 浩

  第24回癌治療増感研究会, 26 May 2018, Invited

  
• 生体内低酸素微小環境と放射線感受性

  原田 浩

  京都大学大学院生命科学研究科・放射線生物研究センター統合記念シンポジウム, 25 May 2018, Invited

  
• 照準を合わせろ！ がんに対する放射線治療の現状と課題

  原田 浩

  第13回京都大学附置研究所・センターシンポジウム；京都からの挑戦 -地球社会の調和ある共存に向けて-, 17 Mar. 2018, Invited

  
• Hypoxic Microenvironments in Malignant Solid Tumors

  Hiroshi Harada

  International Mini-symposium on Organs under Stress, 16 Feb. 2018, Invited

  
• がん・低酸素・HIF-1

  原田 浩

  国立京都医療センター臨床研究センター特別講演会, 05 Feb. 2018, Invited

  
• 腫瘍内微小環境と放射線感受性・抵抗性

  原田 浩

  JASTRO第8回放射線生物学セミナー, 20 Jan. 2018, Invited

  
• 細胞の低酸素応答を担う新規遺伝子の作用機序と機能.

  原田 浩

  08 Dec. 2017, Invited

  
• がんに対する放射線治療の現状・課題・私たちの取り組み；低酸素バイオロジーの視点から

  原田 浩

  富山大学医歯薬総合研究科特別講演会, 24 Nov. 2017, Invited

  
• How can we overcome tumor radioresistance; lessons from hypoxia biology.

  Hiroshi Harada

  The 1st isRTB, 31 Oct. 2017, Invited

  
• がんに対する放射線治療の現状と課題

  原田 浩

  知の拠点セミナー., 20 Oct. 2017, Invited

  
• Radioresistance of Cancer Cells; Lessons from HIF-1 Biology

  原田 浩

  放射線生物学セミナー in Gifu. 岐阜, 16 Oct. 2017, Invited

  
• HIF-1バイオロジーで迫るがんの放射線抵抗性

  原田 浩

  若手放射線生物研究専門研究会, 02 Sep. 2017, Invited

  
• HIF-1の生物学：基礎研究から創薬研究への展開

  原田 浩

  新規分子標的治療薬創薬に向けた大学発ベンチャー基盤の確立シンポジウム, 01 Sep. 2017, Invited

  
• がんの悪性進展と治療抵抗性を担うHIF-1を中心とする遺伝子ネットワーク

  原田 浩

  第5回低酸素研究会, 29 Jul. 2017, Invited

  
• がん細胞のグルコース代謝

  原田 浩

  第19回京都大学大学院生命科学研究科シンポジウム, 07 Jul. 2017

  
• Tumor hypoxia; an imaging and therapeutic target of interest for innovative radiation therapy

  Hiroshi Harada

  The 3rd Bordeaux-Kyoto Symposium, 29 Jun. 2017, Invited

  
• 悪性固形腫瘍内の低酸素環境 -放射線生物学の視点から-

  原田 浩

  日本放射線腫瘍学会 第46回 放射線による制癌シンポジウム, 17 Jun. 2017, Invited

  
• 腫瘍の微小環境と放射線感受性

  原田 浩

  日本放射線腫瘍学会 第7回 放射線生物学セミナー, 28 Jan. 2017, Invited

  
• 現代生物学が放射線治療に指し示すもの

  原田 浩

  九州放射線治療システム研究会, 28 Jan. 2017, Invited

  
• IDH3-HIF-1経路によるがん細胞の糖代謝リプログラミング

  原田 浩

  日本がん分子標的治療学会 第12回トランスレーショナルリサーチワークショップ, 18 Jan. 2017, Invited

  
• がんの悪性化と治療抵抗性を左右する「腫瘍内微小環境」

  原田 浩

  京都大学丸の内セミナー, 02 Dec. 2016, Invited

  
• がん・低酸素・HIF-1

  原田 浩

  京都薬科大学病態生理学セミナー, 25 Nov. 2016, Invited

  
• 生物研究の方向性; 放射線腫瘍学における生物研究

  原田 浩

  日本放射線腫瘍学会第29回学術大会, 25 Nov. 2016, Invited

  
• 悪性固形腫瘍内の微小環境と放射線抵抗性

  原田 浩

  熊本放射線腫瘍研究会, 18 Nov. 2016, Invited

  
• がん・低酸素・HIF-1.

  原田 浩

  Forum in Dojin, 28 Oct. 2016, Invited

  
• HIF-1を中心とする活性酸素ストレス応答の分子基盤と機能

  原田 浩

  日本放射線影響学会第59回大会, 27 Oct. 2016, Invited

  
• Function of the UCHL1-HIF-1 Axis in Distant Metastasis and Radioresistance of Cancer Cells.

  Hiroshi Harada

  International Symposium of Radiation Biology Center, Kyoto University 2016., 01 Sep. 2016, Invited

  
• 放射線生物学・最近の話題 -低酸素とがん幹細胞-

  原田 浩

  日本放射線腫瘍学会（JASTRO）夏季セミナー, 07 Aug. 2016, Invited

  
• がん細胞の糖代謝経路と放射線抵抗性のクロストーク

  原田 浩

  第45回放射線による制癌シンポジウム, 15 Jul. 2016, Invited

  
• Radioresistance of Cancer Cells; Lessons from HIF-1 Biology.

  Hiroshi Harada

  Annual Meeting of Association for Radiation Research 2016, 29 Jun. 2016, Invited

  
• Tumor Hypoxia; a Potent Inducer of Malignant Phenotypes and Radioresistance of Cancer Cells

  Hiroshi Harada

  The 2nd KU RBC-CEA Joint Workshop, 11 Apr. 2016, Invited

  
• 低酸素バイオロジーで迫るがん細胞の放射線抵抗性獲得機構

  原田 浩

  日本放射線影響学会評議員学術講演会, 29 Mar. 2016, Invited

  
• 低酸素バイオロジーへのいざない

  原田 浩

  幹細胞・がん・エピゲノムに関する合同リトリート, 07 Mar. 2016, Invited

  
• がん細胞の放射線抵抗性の理解

  原田 浩

  第2回松島シンポジウム, 04 Mar. 2016, Invited

  
• がん細胞の糖代謝経路リプログラミングと放射線抵抗性

  原田 浩

  癌治療増感研究シンポジウム, 04 Feb. 2016, Invited

  
• Functional and Mechianistic Relationship between HIF-1 and Tumor Radioresistance.

  Hiroshi Harada

  GDN Radiation Biology and Oncology, 28 Jan. 2016, Invited

  
• HIF-1によるがんの悪性化と治療抵抗性.

  原田 浩

  愛知県がんセンター研究所 特別招聘セミナー, 18 Jan. 2016, Invited

  
• Tumor Hypoxia; a Potent Inducer of Tumor Malignant Phenotypes.

  Hiroshi Harada

  International Symposium@The 4th Military Medical University., 07 Jan. 2016, Invited

  
• Importance of Hypoxic Niche; Lessons from Hypoxia and Cancer Biology.

  Hiroshi Harada

  Biochemistry and Molecular Biology 2015 (BMB2015), 02 Dec. 2015, Invited

  
• Molecular Biology for the Advancement of Cancer Radiotherapy; in the Past and the Future.

  Hiroshi Harada

  日本放射線腫瘍学会 第28回学術大会, 19 Nov. 2015, Invited

  
• Tumor Hypoxia, a Potent Inducer of Malignant Phenotypes of Cancer Cells

  Hiroshi Harada

  The 2nd IFOM-Kyoto University Joint International Symposium., 07 Oct. 2015, Invited

  
• IDH3-HIF-1経路によるがん細胞の糖代謝リプログラミング

  原田 浩

  第3回癌と代謝研究会, 15 Jul. 2015, Invited

  
• Oxygen-deficiency; Good or Bad for Cancer Therapy?

  Hiroshi Harada

  The 97th Kyoto University Hakubi Seminar., 07 Jul. 2015, Invited

  
• 低酸素バイオロジーに基づく放射線治療の新展開

  原田 浩

  日本医学放射線学会（JRS）中四国地方会 放射線治療懇話会 特別講演, 27 Jun. 2015, Invited

  
• 放射線腫瘍学の視点でみる「がん幹細胞」

  原田 浩

  広島大学病院放射線治療講演会, 25 Jun. 2015, Invited

  
• 低酸素バイオロジー研究に於けるデータベースの活用例

  原田 浩

  第13回 がんとハイポキシア研究会, 06 Jun. 2015, Invited

  
• Tumor Hypoxia and Radioresistance

  Hiroshi Harada

  The 15th International Congress for Radiation Research (ICRR2015), 28 May 2015, Invited

  
• 低酸素生物学に基づく生体内低酸素の可視化

  原田 浩

  第54回日本生体医工学会, 07 May 2015, Invited

  
• がん細胞の低酸素応答機構の理解と利用

  原田 浩

  京都大学大学院医学研究科皮膚科学講座セミナー, 30 Apr. 2015, Invited

  
• がん幹細胞と腫瘍内低酸素 -癌の診断と治療における重要性と展望-

  原田 浩

  第74回 日本医学放射線学会, 18 Apr. 2015, Invited

  
• がん細胞の低酸素応答機構の理解と利用

  原田 浩

  京都大学再生医科学研究所セミナー, 11 Apr. 2015

  
• 腫瘍内低酸素領域・HIF-1活性を診る意義 -低酸素バイオロジー研究で明らかになったがんの悪性形質獲得メカニズム-.

  原田 浩

  第17回国際癌治療増感シンポジウム, 07 Feb. 2015, Invited

  
• がんの微小環境研究を通して同定された新たな治療標的

  原田 浩

  第3回国際先端生物学・医学・工学会議, 16 Jan. 2015, Invited

  
• Warburg効果（がん細胞の好気的解糖）・温故知新

  原田 浩

  東京医科歯科大学・キャンサーボード/大学院特別講義, 20 Nov. 2014, Invited

  
• UCHL1 provides novel diagnostic and antimetastatic strategy due to its deubiquitinating effect on HIF-1alpha

  Hiroshi Harada

  Hypoxia Meeting, 04 Jul. 2014, Invited

  
• IDH3によるがんの代謝リプログラミング機構の解明と新たな治療法確立への展開

  原田 浩

  第18回日本がん分子標的治療学会学術総会, 26 Jun. 2014, Invited

  
• HIF-1 as a Rational Target for Cancer Therapy

  Hiroshi Harada

  University of Oxford, Oxford Institute for Radiation Oncology Seminar, 29 May 2014, Invited

  
• Importance of HIF-1 in Radiation Oncology

  Hiroshi Harada

  The University of Oxford. Gray Institute for Radiation Oncology & Biology Seminar, 07 Apr. 2014, Invited

  
• FIRST Joint International Symposium; Overcoming Intractable Cancer-a new path to the future

  Hiroshi Harada

  Metabolic Reprogramming of Cancer Cells; a Rational Target for the Diagnosis and Treatment of Cancers., 24 Feb. 2014, Invited

  
• 放射線腫瘍学における分子生物学的実験法

  原田 浩

  日本放射線腫瘍学会 第4回生物学セミナー, 25 Jan. 2014, Invited

  
• 低酸素バイオロジーに基づく放射線治療の新展開

  原田浩

  北里大学がんプロフェッショナル養成プラン セミナー, 23 Nov. 2013, 北里大学がんプロフェッショナル養成プラン, Invited

  
• 放射線生物学・最近の話題

  原田浩

  第26回 日本放射線腫瘍学会学術総会, 19 Oct. 2013, 日本放射線腫瘍学会, Invited

  
• 低酸素がん細胞を治療標的とする根拠

  原田浩

  日本放射線影響学会 第56回大会, 18 Oct. 2013, 日本放射線影響学会, Invited

  
• Molecular Mechanism behind Tumor Radioresistance; Lessons from Hypoxia Biology

  Hiroshi Harada

  The 72nd Annual Meeting of the Japanese Cancer Association, International Symposium Session, 03 Oct. 2013, Japanese Cancer Association, Invited

  
• 低酸素バイオロジーで迫るがんの放射線抵抗性機構の解明

  原田浩

  第42回放射線による制癌シンポジウム, 05 Jul. 2013, 日本放射線腫瘍学会 生物部会, Invited

  
• Molecular Mechanism behind Tumor Recurrence after Radiation Therapy; Lessons from Hypoxia Biology

  Hiroshi Harada

  The 3rd Asian Congress of Radiation Research, 13 May 2013, Asian Association for Radiation Research, Invited

  
• 新規HIF-1活性化因子の治療標的としての有用性

  Hiroshi Harada

  第15回癌治療増感研究シンポジウム, 09 Feb. 2013, 国際癌治療増感研究協会, Invited

  
• 放射線腫瘍学における分子生物学的実験法

  原田浩

  日本放射線腫瘍学会 第3回生物学セミナー, 02 Feb. 2013, 日本放射線腫瘍学会, Invited

  
• 放射線腫瘍学における低酸素バイオロジー

  原田浩

  東京医科歯科大学・大学院特別講義/キャンサーボードミーティング, 18 Oct. 2012, 東京医科歯科大学・大学院特別講義/キャンサーボード, Invited

  
• Cancer cells that acquire HIF-1 activity after radiation therapy cause local tumor recurrence after radiation therapy

  Hiroshi Harada

  The 71st Annual Meeting of Japanese Cancer Association, International Symposium Session, 19 Sep. 2012, Japanese Cancer Association, Invited

  
• HIF-1陰性低酸素がん細胞はS期への細胞周期の移行により放射線抵抗性を獲得する

  原田浩

  日本放射線影響学会第55回大会, 06 Sep. 2012, 日本放射線影響学会, Invited

  
• がん細胞の動きを捉える

  原田浩

  京都大学基礎物理学研究所主導研究会2012, 09 Aug. 2012, 京都大学基礎物理学研究所, Invited

  
• Function of Hypoxia-Inducible Factor 1 in Tumor Recurrence after Radiation Therapy; Lessons from Hypoxia Biology

  Hiroshi Harada

  The 31st Sapporo International Cancer Symposium, 23 Jul. 2012, The Sapporo Cancer Seminar Foundation, Invited

  
• Molecular Mechanism behind Tumor Recurrence after Radiation Therapy

  原田浩

  京都大学 再生医療臓器再建医学コースミーティング, 11 Mar. 2012, 京都大学 iPS細胞研究所, Invited

  
• HIF-1-mediated Cellular Dynamics in Tumor Recurrence after Radiation Therapy

  Hiroshi Harada

  2nd Symposium for ICDO Kyoto Univ, 01 Mar. 2012, Kyoto Univ, Invited

  
• 低酸素細胞を標的としたアプローチ

  原田浩

  第14回 国際癌治療増感研究, 10 Feb. 2012, 国際癌治療増感研究協会, Invited

  
• 放射線治療後のがん局所再発におけるhypoxia-inducible factor 1 (HIF-1)の機能

  原田浩

  53回 日本放射線影響学会学術総会, 18 Nov. 2011, 日本放射線影響学会, Invited

  
• 放射線治療後の腫瘍局所再発における腫瘍低酸素とHIF-1の役割

  原田浩

  京都府立医科大学 細胞生理学教室セミナー, 19 Oct. 2011, 京都府立医科大学 細胞生理学教室, Invited

  
• 放射線治療後のがん再発機構の解明とその克服

  原田浩

  第2回 芝蘭会産学情報交換会, 12 Oct. 2011, 京都大学 芝蘭会, Invited

  
• 放射線治療後のがん再発機構の解明とその克服 -低酸素バイオロジーと放射線腫瘍学の接点-

  原田浩

  名古屋市立大学大学院システム自然科学研究科 田上研究室（クロマチン制御学）セミナー, 30 Sep. 2011, 名古屋市立大学大学院システム自然科学研究科, Invited

  
• Molecular Mechanism behind HIF-1-mediated Radioresistance and Postirradiation Recurrence of Malignant Solid Tumors

  Hiroshi Harada

  The 14th International Congress of Radiation Research, 30 Aug. 2011, International Association for Radiation Research, Invited

  
• 光イメージングで迫る腫瘍低酸素がん細胞の動態とがん再発への寄与

  原田浩

  第23回 日本化学会 生体機能関連化学部会サマースクール, 22 Jul. 2011, 日本化学会 生体機能関連化学部会, Invited

  
• 光イメージングとトラッキングで迫る腫瘍低酸素のダイナミクスと治療抵抗性への影響

  原田浩

  第44回 日本整形外科学会 骨・軟部腫瘍学術集会, 14 Jul. 2011, 日本整形外科学会, Invited

  
• HIF-1によるがんの放射線抵抗性機構の解明とその克服

  原田浩

  第70回 日本医学放射線学会総会, 07 Apr. 2011, 日本医学放射線学会, Invited

  
• 放射線生物学的視点で迫る「腫瘍低酸素・放射線抵抗性・がん再発の時空間関係」

  原田浩

  第13回 国際癌治療増感シンポジウム, 11 Feb. 2011, 国際癌治療増感研究協会, Invited

  
• Tracking the dynamics of hypoxic tumor cells during tumor growth and after radiation therapy

  Hiroshi Harada

  The 1st International Symposium for Molecular-targeting Radiation Therapy, 03 Feb. 2011, First Program, NEXT, Japan, Invited

  
• Function of HIF-1 in Local Tumor Recurrence after Radiation Therapy

  原田浩

  東北大学・加齢医学研究所セミナー, 19 Nov. 2010, 東北大学・加齢医学研究所, Invited

  
• 光イメージングで迫る放射線治療後のがん再発メカニズム

  原田浩

  東北大学大学院 医学研究科附属 創生応用医学研究センター 酸素医学コアセンターシンポジウム, 19 Nov. 2010, 東北大学大学院 医学研究科附属 創生応用医学研究センター 酸素医学コアセンター, Invited

  
• HIF-1（Hypoxia-inducible Factor 1）による細胞の低酸素応答メカニズム

  原田浩

  東北大学・医学研究科 運動学分野セミナー, 18 Nov. 2010, 東北大学・医学研究科 運動学講座, Invited

  
• 放射線治療後のがん局所再発におけるHIF-1の機能

  原田浩

  東北大学・薬学研究科セミナー, 17 Nov. 2010, 東北大学・薬学研究科, Invited

  
• 高精度放射線治療法の確立を見据えた低酸素イメージングの方向性

  原田浩

  第50回日本核医学会学術総会, 12 Nov. 2010, 日本核医学会, Invited

  
• 低酸素がん細胞の腫瘍内ダイナミクスと放射線治療抵抗性

  原田浩

  第69回日本癌学会学術総会, 23 Sep. 2010, 日本癌学会, Invited

  
• HIF-1イメージングによるがんの放射線抵抗性機構の解析

  原田浩

  東京医科歯科大学・キャンサーボードミーティング, 16 Sep. 2010, 東京医科歯科大学・キャンサーボード, Invited

  
• 低酸素がん細胞の腫瘍内動態解析 ～がんの再発メカニズムの解明～

  原田浩

  群馬大学Clinical Oncology Research研究会, 03 Jun. 2010, 群馬大学医学研究科, Invited

  
• Tracking the Dynamics of Hypoxic Tumor Cells during Local Tumor Recurrence after Radiation Therapy

  Hiroshi Harada

  Fourth Military Medical University International Seminar, 24 May 2010, Fourth Military Medical University, Invited

  
• 光イメージングで迫る“がんの放射線抵抗性機構の解析

  原田浩

  日本歯科大学セミナー, 02 Apr. 2010, 日本歯科大学, Invited

  
• Reoxygenation, HIF-1, and Radioresistance

  原田浩

  第12回癌治療増感研究シンポジウム, 14 Feb. 2010, 国際癌治療増感研究協会, Invited

  
• 光イメージングで迫る癌の放射線抵抗性機構

  原田浩

  若手放射線生物学研究会 第1回新春勉強会, 30 Jan. 2010, 若手放射線生物学研究会, Invited

  
• 低酸素誘導性因子-1(HIF-1)による癌の放射線耐性機構の解明とその克服

  原田浩

  日本放射線影響学会 第52回大会, 13 Nov. 2009, 日本放射線影響学会, Invited

  
• Peri-necrotic tumor cells cause recurrence after radiotherapy through migration to tumor blood vessels

  Hiroshi Harada

  International Symposium/Retreat, Kyoto University Global COE Program, 07 Nov. 2009, Kyoto University Graduate School of Medicine, Invited

  
• Optical Imaging of Tumor Hypoxia, Cell Cycle, pH, and DNA double strand breaks to Analyze the Molecular Mechanism Underlying Tumor Radioresistance

  Hiroshi Harada

  The 3rd International Symposium on Nanomedicine, 04 Nov. 2009, International Association of Nanomedicine, Invited

  
• In vivo光イメージングによる“がんの放射線抵抗性機構”へのアプローチ

  原田浩

  徳島大学大学院ソシオテクノサイエンス研究部セミナー, 29 Oct. 2009, 徳島大学大学院ソシオテクノサイエンス研究部, Invited

  
• A Molecular Mechanism Underlying HIF-1-mediated Tumor Radioresistance

  原田浩

  第68回日本癌学会学術総会, 03 Oct. 2009, 日本癌学会, Invited

  
• HIF-1の活性化を介した癌の巧妙な放射線耐性機構 ～in vivo光イメージングによるアプローチ～

  原田浩

  第41回日本臨床分子形態学会学術総会, 05 Sep. 2009, 日本臨床分子形態学会, Invited

  
• がんの放射線耐性機構の解明と放射線治療への展開 -HIF-1活性のイメージング研究に基づく提言-

  原田浩

  第39回 放射線による制癌シンポジウム, 11 Jul. 2009, 日本医学放射線学会・生物部会, Invited

  
• Tumor Hypoxia: A Microenvironmental Target in Cancer Therapy

  Hiroshi Harada

  The 2nd Asian Congress for Radiation Research, 20 May 2009, Asian Association for Radiation Research, Invited

  
• Optical Imaging of Intratumoral HIF-1 Activity to Elucidate the Mechanism Underlying HIF-1-mediated Tumor Radioresistance

  Hiroshi Harada

  The 2nd Asian Congress for Radiation Research, 19 May 2009, Asian Association for Radiation Research, Invited

  
• Identification of the source of Tumor recurrence after radiation therapy

  Hiroshi Harada

  Radiation Oncology Seminar in Seoul National University, 18 May 2009, Seoul National University, Invited

  
• A Molecular Mechanism Underlying the HIF-1-mediated Radioresistance of Solid Tumors

  Hiroshi Harada

  Massachusetts General Hospital (MGH) Special Seminar, 20 Sep. 2008, Massachusetts General Hospital (MGH), Invited

  
• Tumor Hypoxia and HIF-1. International Symposium for Cancer Therapy

  Hiroshi Harada

  China-Japan Bilateral Seminar on Radiation Medicine from Bench to Clinic, 20 Nov. 2007, The Fourth Military Medical University, China, Invited

  
• 低酸素応答因子（HIF-1）の活性を利用した腫瘍内低酸素領域の光イメージング

  原田浩

  第37回 放射線による制癌シンポジウム, 20 Jul. 2007, 日本医学放射線学会 生物部会, Invited

  
• Real-time Imaging of Tumor Hypoxia as HIF-1-dependent Bioluminescence and Fluorescence

  Hiroshi Harada

  International Symposium for Cancer Therapy, 14 Mar. 2007, Chinese Academy of Medical Science, Invited

  
• Optical Imaging of HIF-1 activity in Tumor Xenografts

  Hiroshi Harada

  International Crosscutting Symposium; Molecular Bio-imaging And 4D Image-guided Radiotherapy, 14 Jul. 2006, Hokkaido University, Invited

  

Books and Other Publications

• 放射線治療学 改訂７版

  諏訪達也; 原田浩, Contributor, 放射線治療の基礎 B. 放射線生物学

  南山堂, Dec. 2023

  Find Kyoto University's collection of books :

  
• がん・放射線療法 改訂第8版

  原田浩, Contributor, 第3章 放射線生物学 3-5修飾因子

  Sep. 2023

  
• Molecularly based Chemoradiotherapy and High-Precision Radiotherapy. Tan D, Lynch H (eds).

  Yoshimura M; Hiraoka M; Harada H

  Lippincott Williams & Milkins., 2012, Not refereed

  
• Protein Transduction Domain-mediated Delivery of Anti-cancer Drugs and Proteins. Lu Y and Mahato RI (eds). Pharmaceutical Perspectives of Cancer Therapeutics.

  Harada H; Hiraoka M

  Springer, 2009, Not refereed

  
• Combination of Antimetabolites and Ionizing Radiation. Medical Radiology: Radiation Oncology, Multimodal Concepts for Integration of Cytotoxic Drugs.

  Harada H; Shibuya K; Hiraoka M

  Springer, 2006, Not refereed

  

Industrial Property Rights

• 特願PCT/JP2022/024612, 低酸素バイオマーカー及びその利用

  諏訪達也; 小林稔; 原田浩

  
• 特願2021-108196, 低酸素バイオマーカー及びその利用

  諏訪達也; 小林稔; 原田浩

  
• 特願PCT/JP2020/029217, がんを治療するための医薬組成物

  子安翔; 原田浩

  
• 特願2019-141624, がんを治療するための医薬組成物

  子安翔; 原田浩

  
• 特許6046618, 特開WO 2012176651 A1, 特願2013-521531, 新規抗腫瘍剤及び新規抗腫瘍剤のスクリーニング方法

  原田浩; 平岡真寛

  
• 特許5093776, 病態の状態をリアルタイムで観察可能なモデル動物とそれを可能にする遺伝子構築物及びその使用

  オリエンタル酵母株式会社

  
• 特許US 7700754 B1, Polypeptide unstablizing protein in cells under aerobic conditions and DNA encoding the same

  平岡真寛; 近藤科江; 原田浩

  
• 特許4130955 (JP), 有酸素条件下の細胞で不安定化するタンパク質をコードするDNA

  平岡真寛; 近藤科江; 原田浩

  
• 特許200230416 (Aus), Polypeptide unstabilizing protein in cells under aerobic conditions and DNA encoding the same

  平岡真寛; 近藤科江; 原田浩

  

Awards

• Nov. 2023

  JRRS, JRRS Distinguished Scientist Award
• Jun. 2023

  Osaka Neuclear Science Association, ONSA Award
• Oct. 2022

  Japanese Society for Radiation Oncology, Abe Award
• 08 Nov. 2018

  Journal of Radiation Research, JRR Terasima Award
• 2014

  JASTRO, Excellent Lecture Award
• 2013

  JRRS, Incitement Award
• 2009

  JRRS, Incitement Award
• 2009

  IASCT, Incitement Award
• 2009

  JCA, Incitement Award
• 2009

  JAMTTC, Special Award
• 2009

  AARR, Young Scientist Award
• 2008

  JAMTTC, Incitement Award
• 2007

  JRRS, Excellent Paper Award

External funds: Kakenhi

• Assessment of the relationship between the dynamics of tumor hypoxia areas and hypoxia inducible factor in radiotherapy for pancreatic cancer

  Grant-in-Aid for Scientific Research (C)

  Basic Section 52040:Radiological sciences-related

  Kyoto University

  吉村 通央

  From 01 Apr. 2021, To 31 Mar. 2026, Granted

  Radiotherapy;Pancreatic cancer;Hypoxia

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K07671/
• 放射線抵抗性の腫瘍内低酸素分画をモニターする血中バイオマーカーの開発

  Grant-in-Aid for Scientific Research (B)

  Basic Section 52040:Radiological sciences-related

  Kyoto University

  原田 浩

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  がん;低酸素;マーカー;微小環境

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02855/
• 放射線抵抗性の腫瘍内低酸素分画をモニターする血中バイオマーカーの開発

  Grant-in-Aid for Scientific Research (B)

  Basic Section 52040:Radiological sciences-related

  Kyoto University

  原田 浩

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  がん;低酸素;マーカー;微小環境

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27546/
• Identification of stromal subcellular population which exhiites active HIF signaling and is responsible for radioresistance of cancer

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 52:General internal medicine and related fields

  Kyoto University

  原田 浩

  From 30 Jun. 2023, To 31 Mar. 2025, Granted

  がん;放射線;低酸素;ストローマ細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K18274/
• がん個別化放射線治療法の確立に向けたTR研究

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

  Medium-sized Section 52:General internal medicine and related fields

  Kyoto University

  原田 浩

  From 07 Oct. 2021, To 31 Mar. 2024, Granted

  がん;放射線治療;微小環境;低酸素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21KK0144/
• 新規リアルタイムDNA損傷修復応答検出システムの構築と腫瘍内DNA損傷応答の解析

  Grant-in-Aid for Scientific Research (C)

  Basic Section 52040:Radiological sciences-related

  Kyoto University

  小林 稔

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  DNA損傷修復;In vivo imaging

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K07727/
• Genome-wide screening of blood markers for hypoxic cancer cells within malignant solid tumors

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 52:General internal medicine and related fields

  Kyoto University

  Hiroshi Harada

  From 09 Jul. 2021, To 31 Mar. 2023, Project Closed

  がん;微小環境;低酸素;マーカー;が

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19445/
• Monitoring Tumor Hypoxia and Sensitizing Radiotherapy Effects by Using Hypoxia-Inducible Secreted Proteins

  Grant-in-Aid for Scientific Research (B)

  Basic Section 52040:Radiological sciences-related

  Kyoto University

  Hiroshi Harada

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  がん;微小環境;低酸素;マーカー;増感

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03621/
• 腫瘍微小環境をドライビングフォースとする腫瘍内遺伝型不均一性の解析

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  原田 浩

  From 01 Apr. 2020, To 31 Mar. 2022, Project Closed

  がん;微小環境;低酸素;DNA損傷修復;多様性

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-20H05033/
• A novel invasion-related gene involved in tumor recurrence after radiation therapy

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 52:General internal medicine and related fields

  Kyoto University

  Hiroshi Harada

  From 28 Jun. 2019, To 31 Mar. 2021, Project Closed

  がん;低酸素;浸潤・転移関連遺伝子;放射線治療;放射線抵抗性;HIF-1;再発;浸潤;抵抗性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22595/
• Mechanism of Action and Function of a novel HIF-1 activator in p53-deficient cancers

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

  Medium-sized Section 52:General internal medicine and related fields

  Kyoto University

  Hiroshi Harada

  From 09 Oct. 2018, To 31 Mar. 2021, Project Closed

  がん;低酸素;浸潤・転移関連遺伝子;治療抵抗性;がん抑制遺伝子;HIF-1;p53;浸潤;Sima;放射線

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18KK0241/
• 臓器間のDNA損傷耐用能の違いから迫る「宇宙放射線克服ストラテジーの基盤構築」

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Kyoto University

  原田 浩

  From 01 Apr. 2018, To 31 Mar. 2020, Project Closed

  宇宙放射線;DNA損傷;抗酸化活性;遺伝子改変マウス;遺伝子改変動物;放射線

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-18H04977/
• Novel gene network responsible for hypoxic response and radioresistance of cancer cells

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Akiyo Morinibu

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  がん;放射線;低酸素;放射線抵抗性;放射線治療;放射線抵抗壊死;新規責任遺伝子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10474/
• Interplay between the molecular mechanism for hypoxia response and that for antioxidant capacity

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Hiroshi Harada

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  がん;低酸素応答;抗酸化能;放射線抵抗性;血中マーカー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04261/
• Genome-wide Screening of Novel Genes Responsible for Tumor Radioresistance

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Hiroshi Harada

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  がん;放射線;治療抵抗性;責任遺伝子;スクリーニング;抵抗性;原因遺伝子;遺伝学的スクリーニング;放射線抵抗性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15576/
• 放射線被ばくが主要臓器に及ぼす影響に迫る「遺伝子改変動物を用いた時空間解析」

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  原田 浩

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  放射線;DNA損傷;遺伝子改変動物;宇宙放射線;光イメージング

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-16H01640/
• 多段階発癌に於ける低酸素応答機構と癌抑制遺伝子のクロストークに迫るオミクス解析

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  原田 浩

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  がん;代謝;低酸素;多段階発がん;オミクス

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-16H01573/
• Interplay between a circadian clock regulator, PER2, and HIF-1

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Akiyo Morinibu

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  がん;低酸素;概日リズム;HIF-1;糖代謝

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461886/
• Molecular Mechanisms behind Cancer Cells-specific Oxygen Homeostasis and Their Influence on Tumor Radioresistance

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Hiroshi Harada

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  放射線治療;がん;治療抵抗性;酸素恒常性;エネルギー代謝;HIF-1;低酸素;微小環境;放射線治療抵抗性;低酸素応答

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293276/
• Spatiotemporal analyses of the dynamics of hypoxic tumor cells for the optimization of fractionated radiation therapy for cancers

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Hiroshi Harada

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  がん;放射線治療;分割照射;腫瘍内低酸素;HIF-1;放射線治療抵抗性;低酸素;細胞動態

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670558/
• Importance of hypoxic regions as cancer stem cell niche; in vivo analyses using a novel mouse model

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Masahiro Hiraoka

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  がん;放射線治療;がん幹細胞;低酸素;HIF-1;腫瘍内低酸素;放射線抵抗性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670555/
• Enhancement of anti-tumor activity of hybrid peptide by complexation with high molecular weight biodegradable polymers

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Arong GAOWA

  From 01 Apr. 2013, To 31 Mar. 2015, Project Closed

  癌;DDS;ペプチド;動態

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860113/
• Optical Imaging of Intratumoral HIF-1 activity to Optimize Treatment Regimens for Chemoradiotherapy

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Hiroshi HARADA

  From 01 Apr. 2009, To 31 Mar. 2011, Project Closed

  放射線;腫瘍(がん);低酸素;微小環境;光イメージング;悪性腫瘍(がん)

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21791184/
• Innovative strategies in radiation therapy targeting tumor hypoxia by biological and physical approaches.

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  Mashiro HIRAOKA

  From 01 Apr. 2005, To 31 Mar. 2010, Project Closed

  低酸素;イメージング;強度変調放射線治療;蛋白質製剤;同所性移植モデル;放射線治療;低酸素がん細胞;がん治療;標的特異性;標的治療

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17016036/
• Spatiotemporal Analysis of Tumor Microenvironments Relating to Radioresistance of Tumor Cells

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Hiroshi HARADA

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  放射線治療学;放射線;生体イメージング;腫瘍(がん);低酸素;微小環境

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19790868/
• 分子標的薬と放射線の併用効果と副作用:マウス肺癌モデルを用いたメカニズムの解明

  Grant-in-Aid for Exploratory Research

  Kyoto University

  澁谷 景子

  From 01 Apr. 2006, To 31 Mar. 2009, Project Closed

  肺癌;放射線治療;分子標的治療;同所性移植モデル;イメージング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18659347/
• Investigation on the molecular mechanism of maintenance of oxygen homeostasis by hypoxia-inducible factor 1 system

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Kiichi HIROTA

  From 01 Apr. 2006, To 31 Mar. 2009, Project Closed

  周術期管理学;遺伝子;細胞;低酸素;シグナル伝達;転写因子;HIF-1;ストレス;細胞・組織;発現制御

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390429/
• 放射線治療抵抗性克服に向けた腫瘍低酸素分画の予知と新規治療戦略開発

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  平岡 眞寛;平岡 真寛

  From 01 Apr. 2004, To 31 Mar. 2005, Project Closed

  放射線治療;低酸素がん細胞;がん治療;標的特異性;遺伝子治療;イメージング;放射線科学;ハイポキシア;コメットアッセー;HIF-1α;HRE;アデノウイルス;HIV-1 tat PTD;ODD domain;低酸素;転写調節;低酸素細胞;コメットアッセイ;低酸素環境;悪性腫瘍;アポトーシス;c-IAP2;BAX

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12217066/
• 低酸素環境がDNA損傷修復機構に及ぼす影響の解析：腫瘍不均一性の理解に向けて

  Fund for the Promotion of Joint International Research (International Collaborative Research)

  Medium-sized Section 50:Oncology and related fields

  Kyoto University

  原田 浩

  From 09 Sep. 2024, To 31 Mar. 2027, Adopted

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24KK0151/

External funds: others

• 腫瘍内低酸素を指標にした“がんの早期発見”と“予後予測”を可能にする血漿バイオマーカー

  研究領域D（診断/バイオマーカー）

  国立研究開発法人日本医療研究開発機構（AMED）, 次世代がん医療加速化研究事業

  From 16 Sep. 2022, To 31 Mar. 2025

  原田浩

  溝脇尚志　吉村通央　小林稔

  研究開発代表者
• 生体内の複雑系を対象とする統合放射線科学の国際研究拠点の形成 (2023年度分)

  Japan Society for the Promotion of Science (JSPS), 研究拠点形成事業　A.先端拠点形成型

  From 01 Apr. 2023, To 31 Mar. 2024

  代表者
• 生体内の複雑系を対象とする統合放射線科学の国際研究拠点の形成 (2022年度分)

  Japan Society for the Promotion of Science (JSPS), 研究拠点形成事業　A.先端拠点形成型

  From 01 Apr. 2022, To 31 Mar. 2023

  代表者
• 悪性かつ治療抵抗性の低酸素腫瘍画分をモニターする体外診断薬の開発 (2021年度分)

  京都市, 京都発革新的医療技術研究開発助成事業

  From 01 Apr. 2021, To 31 Mar. 2022

  代表
• 生体内の複雑系を対象とする統合放射線科学の国際研究拠点の形成 (2021年度分)

  Japan Society for the Promotion of Science (JSPS), 研究拠点形成事業　A.先端拠点形成型

  From 01 Apr. 2021, To 31 Mar. 2022

  代表者
• 生体内の複雑系を対象とする統合放射線科学の国際研究拠点の形成（2020年度）

  JSPS研究拠点形成事業（A先端拠点形成型）

  From 01 Apr. 2020, To 31 Mar. 2021

  原田浩
• 低酸素誘導性の新規分泌蛋白質HISP2の活用による個別化放射線治療の実現 （2020年度分）

  京都発革新的医療技術研究開発助成事業

  From 01 Apr. 2020, To 31 Mar. 2021

  原田　浩
• 生体内の複雑系を対象とする統合放射線科学の国際研究拠点の形成 （2020年度分）

  研究拠点形成事業　A.先端拠点形成型

  From 01 Apr. 2020, To 31 Mar. 2021

  原田　浩
• p53変異型腫瘍の進展を促進する新規遺伝子に対する阻害剤の探索（2020年度）

  AMED創薬支援推進事業

  From 01 Apr. 2020, To 31 Dec. 2020

  原田浩
• がんの悪性進展を促進する新規遺伝子ネットワークに対する阻害剤の開発（2019年度）

  AMED 橋渡し研究戦略的推進プログラム シーズA

  From 01 Apr. 2019, To 31 Mar. 2020

  原田浩
• p53変異型腫瘍の進展を促進する新規遺伝子に対する阻害剤の探索（2019年度）

  AMED創薬支援推進事業

  From 01 Apr. 2019, To 31 Mar. 2020

  原田浩
• 分子腫瘍学・構造生物学・理論化学・臨床医学の融合による「がんの悪性進展促進因子HPF4に対するドラッグデザイン研究」（2019年度）

  AMED創薬基盤推進研究事業

  From 01 Apr. 2019, To 31 Mar. 2020

  原田浩
• がんの悪性化と放射線抵抗性に迫る「放射線腫瘍生物学と数理解析の融合研究」

  二国間交流事業. 日英オープンパートナーシップ

  From 01 Apr. 2017, To 31 Mar. 2019

  原田浩
• がんの悪性化と放射線抵抗性に迫る「放射線腫瘍生物学と数理解析の融合研究」 （平成30年度分）

  二国間交流事業共同研究・セミナー

  From 01 Apr. 2018, To 31 Mar. 2019

  原田 浩
• p53変異型腫瘍の進展を促進する新規遺伝子に対する阻害剤の探索

  AMED創薬支援推進事業

  From 01 Jan. 2019, To 31 Mar. 2019

  原田浩
• 分子腫瘍学・構造生物学・理論化学・臨床医学の融合による「がんの悪性進展促進因子HPF4に対するドラッグデザイン研究」

  AMED創薬基盤推進研究事業

  From 01 Apr. 2018, To 31 Mar. 2019

  原田浩
• pH恒常制御による動物個体の形態維持とその破綻

  JST さきがけ

  From 01 Oct. 2014, To 31 Mar. 2018

  原田浩
• 分子腫瘍学・構造生物学・理論化学・臨床医学の融合による「がんの悪性進展促進因子HPF4に対するドラッグデザイン研究」

  AMED創薬基盤推進研究事業

  From 01 Apr. 2017, To 31 Mar. 2018

  原田浩
• がんの悪性化と放射線抵抗性に迫る「放射線腫瘍生物学と数理解析の融合研究」 （平成29年度分）

  二国間交流事業共同研究・セミナー

  From 01 Apr. 2017, To 31 Mar. 2018

  原田 浩
• 悪性がんの酸素恒常性維持機構と放射線治療抵抗性のクロストーク

  JSPS 二国間交流事業. 日英オープンパートナーシップ

  From 01 Oct. 2014, To 31 Mar. 2016

  原田浩
• 転写活性化シグナルを標的とした革新的抗ガン化合物シーズの開発研究

  MEXT 次世代がん研究シーズ戦略的育成プログラム　

  From Dec. 2014, To 31 Mar. 2016

  掛谷秀昭
• 悪性がんの酸素恒常性維持機構と放射線治療抵抗性のクロストーク （平成27年度分）

  二国間交流事業共同研究・セミナー

  From 01 Apr. 2015, To 31 Mar. 2016

  原田　浩
• 悪性がんの酵素恒常性維持機構と放射線治療抵抗性のクロストーク （平成26年度分）

  二国間交流事業共同研究・セミナー

  From 01 Apr. 2014, To 31 Mar. 2015

  原田　浩
• 放射線治療抵抗性がん細胞の腫瘍内局在・動態の解明とイメージングプローブの開発

  最先端・次世代研究開発支援プログラム

  From 01 Feb. 2011, To 31 Mar. 2014

  原田浩
• 放射線治療抵抗性がん細胞の腫瘍内局在・動態の解明とイメージングプローブの開発

  最先端・次世代研究開発支援プログラム

  From 2010, To 2013

  原田 浩
• 京都市 京都発革新的医療技術研究開発助成事業

  From 2013, To 2013

  原田　浩
• 化学放射線療法抵抗性の低酸素がん細胞を標的とする抗がん剤の開発 -抗がん剤のプロドラッグ化技術と分子イメージングによる薬効評価系を基盤に-

  （独）医薬基盤研究所　保健医療分野における基礎研究推進事業

  From 2009, To 2010

  原田浩
• 分子標的薬剤と革新的放射線治療を用いた新たながん治療戦略

  日中医学交流事業

  From 2006, To 2007

  平岡真寛
• 低酸素刺激に応答して蛍光を発する癌細胞を利用した創薬システムの開発

  JST シーズ発掘試験

  From 2007, To 2007

  原田浩

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Course in Studies on Signal Transduction

  1029, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Molecular Biology II

  2703, Fall, Faculty of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Experiments in Systemic Life Sciences

  5013, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Experiments in Systemic Life Sciences

  5013, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Cancer Biology

  1022, Fall, Graduate School of Biostudies, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Molecular and Cell Biology I

  1016, Spring, Graduate School of Biostudies, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Biology and Life Science

  N484, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Course in Studies on Signal Transduction

  1029, Fall, Graduate School of Biostudies, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Molecular Biology II

  2703, Fall, Faculty of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Experiments in Systemic Life Sciences

  5013, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Experiments in Systemic Life Sciences

  5013, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Cancer Biology

  1022, Fall, Graduate School of Biostudies, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Molecular and Cell Biology I

  1016, Spring, Graduate School of Biostudies, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Course in Studies on Signal Transduction

  1029, Fall, Graduate School of Biostudies, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Molecular Biology II

  2703, Fall, Faculty of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Experiments in Systemic Life Sciences

  5013, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Experiments in Systemic Life Sciences

  5013, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Molecular and Cell Biology I

  1016, Spring, Graduate School of Biostudies, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Cancer Biology

  1022, Fall, Graduate School of Biostudies, 2
• From Apr. 2011, To Mar. 2012

  Advanced Basic Physical Chemistry II

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Molecular and Cell Biology I

  Spring, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Cancer Biology

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Molecular and Cell Biology I

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Cancer Biology

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar A

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar A

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar B

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar B

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar C

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar C

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar D

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar D

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Molecular Biophysics

  Spring, 工学部
• From Apr. 2018, To Mar. 2019

  Introduction to Biology and Life Science

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Molecular and Cell Biology I

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Cancer Biology

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar A

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar A

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar B

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar B

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar C

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar C

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar D

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar D

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Molecular Biophysics

  Spring, 工学部
• From Apr. 2019, To Mar. 2020

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Molecular and Cell Biology I

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Cancer Biology

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  ILAS Seminar :Why we get cancer, and how we tackle it.

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Molecular Biophysics

  Spring, 工学部
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Cancer Biology

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  ILAS Seminar :Why we get cancer, and how we cope with it?

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Advanced Course in Studies on Signal Transduction

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Molecular Biophysics

  Spring, 工学部
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科

Participation in PhD Defense

• 神経膠芽腫細胞におけるグルコース依存性及びSLC7A11/xCT発現制御に対する細胞密度の影響と分子機構の研究

  YAMAGUCHI ITSUKI, Graduate School of Biostudies, Sub-chief Examiner

  25 Mar. 2024
• DDX5による低酸素誘導性転写因子HIF-1の活性増強機構の解析と下流遺伝子の同定

  SHIRAI YUKARI, Graduate School of Biostudies, Chief Examiner

  25 Mar. 2024
• 過酸化水素処理後のゲノム安定性維持に関わるCST複合体の機能解析

  HARA TOMOHIKO, Graduate School of Biostudies, Sub-chief Examiner

  24 Nov. 2023
• The molecular mechanism of mitotic telomere deprotection

  DIANA ROMERO ZAMORA, Graduate School of Biostudies, Sub-chief Examiner

  25 Sep. 2023
• ZBTB2-mediated mechanisms behind the expression of a specific subset of HIF-1 target genes under hypoxia

  Christalle Cheuk Tung Chow, Graduate School of Biostudies, Chief Examiner

  25 Sep. 2023
• ピリミジン合成酵素阻害による核内poly(A)+ RNA代謝への影響解析

  MIYAKE SHUNTAROU, Graduate School of Biostudies, Sub-chief Examiner

  23 Mar. 2023
• 深部生体イメージングを目指したヘム代謝改変による近赤外蛍光タンパク質の高輝度化

  KOBACHI KENJU, Graduate School of Biostudies, Sub-chief Examiner

  23 Mar. 2023
• Investigation of the role of FXR1 and SLFN11 in cellular response to genotoxic stress

  Qi Fei, Graduate School of Human and Environmental Studies, Sub-chief Examiner

  23 Mar. 2023
• MDA5-mediated type I interferonopathy mouse model displays lethal response to immune stimulation

  FRANCINE LIANNE C. EMRALINO, Graduate School of Biostudies, Sub-chief Examiner

  23 Jan. 2023
• Intracellular dsRNA induces apoptotic cell death via the synergistic activation of PKR and TLR3

  ZUO WENJIE, Graduate School of Biostudies, Sub-chief Examiner

  26 Sep. 2022
• Regulation of DNA double-strand breaks during meiotic prophase in the nematode C. elegans

  Guo Heyun, Graduate School of Biostudies, Sub-chief Examiner

  26 Sep. 2022
• マウス側脳室脈絡叢からのSonic hedgehogの分泌が側脳室脈絡叢の肥大と大脳新皮質表面積の拡大をもたらす

  KINOSHITA AKIRA, Graduate School of Biostudies, Sub-chief Examiner

  23 Mar. 2022
• 炎症刺激時における炎症関連RNA分解酵素Regnase-1の制御機構の解析

  AKAKI KOTARO, Graduate School of Biostudies, Sub-chief Examiner

  23 Mar. 2022
• 細胞老化誘導のマスター制御遺伝子Pointedの同定とそれによるがん制御機構の解明

  ITO TAKAO, Graduate School of Biostudies, Sub-chief Examiner

  26 Jul. 2021
• 高インスリン血症はがん抑制性細胞競合を破綻させ腫瘍化を促す

  佐奈喜　祐哉, Sub-chief Examiner

  23 Sep. 2020
• CD44を介する乳癌細胞のクラスター形成機構の解明

  大前　まどか, Sub-chief Examiner

  23 Sep. 2020
• 多倍体肥大化細胞による腫瘍進展メカニズムの遺伝学的解析

  叢　博杰, Sub-chief Examiner

  23 Mar. 2020
• Investigation of G1 Arrest Mechanisms Induced by Sanguisorba　officinalis Extracts in B16F10 Cells(Sanguisorba officinalis の抽出物がB16F10細胞に誘導するG1 arrest の誘導機構の解析）

  TAN YI-HSUN, Sub-chief Examiner

  25 Nov. 2019
• Critical functions of Reck in mouse forebrain development（マウス前脳発生におけるReckの重要な役割）

  李　会平, Sub-chief Examiner

  25 Nov. 2019
• 悪性黒色腫細胞B16F10における、emodinの細胞内ATPレベルと増殖に対する効果と作用機序の解明

  杉山　悠真, Sub-chief Examiner

  24 Sep. 2019
• 分泌タンパク質Serpin5はTollシグナル制御を介してがん抑制性細胞競合を促進する

  勝川　美都子, Sub-chief Examiner

  25 Mar. 2019
• 結核肉芽腫におけるS100A9タンパク質の発現と機能に関する研究

  吉岡　佑弥, Sub-chief Examiner

  25 Mar. 2019
• Deletion of IKKβ in smooth muscle cells induces vascular calcification through β-catenin-Runx2 signaling(平滑筋におけるIKKβ欠損はβカテニン-Runx2のシグナル伝達を介して血管石灰化を促進する)

  Ｉｓｅｈａq　ＡＬ　Ｈｕｓｅｉｎｉ, Sub-chief Examiner

  26 Mar. 2018
• Volumetric modulated Dynamic WaveArc therapy reduces the dose to the hippocampus in patients with pituitary adenomas and craniopharyngiomas(Volumetric modulated Dynamic WaveArc法は下垂体腺腫・頭蓋咽頭腫症例における海馬線量を低減する)

  宇藤　恵, Chief Examiner

  26 Mar. 2018
• Analysis of the microvascular morphology and hemodynamics of breast cancer in mice using SPring-8 synchrotron radiation microangiography(SPring-8放射光微小血管造影法を利用したマウス腫瘍微小血管形態および血流動態の検討)

  鳥井　雅恵, Chief Examiner

  26 Mar. 2018
• Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells(上皮様および間葉様食道扁平上皮癌細胞に対する、EGFR阻害剤の相異なる作用)

  吉岡　正博, Chief Examiner

  23 Jan. 2018
• Cellular context-dependent consequences of Apc mutations on gene regulation and cellular behavior(Apc変異による遺伝子発現や細胞動態への影響は細胞種に依存する)

  橋本　恭一, Sub-chief Examiner

  23 Jan. 2018
• Suppression of ABHD2, identified through a functional genomics screen, causes anoikis resistance, chemoresistance and poor prognosis in ovarian cancer.(機能的ゲノミクススクリーンにより同定した因子ABHD2の発現低下は、卵巣癌のアノイキス抵抗性、化学療法抵抗性をもたらし、予後不良につながる)

  山ノ井　康二, Sub-chief Examiner

  25 Sep. 2017
• Liver specific Prox1 inactivation causes hepatic injury and glucose intolerance in mice(マウス肝臓特異的Prox1不活化は肝障害と耐糖能異常を引き起こす)

  後藤　俊彦, Chief Examiner

  23 May 2017
• Loss of SMAD4 Promotes Lung Metastasis of Colorectal Cancer by Accumulation of CCR1+ Tumor-associated Neutrophils through CCL15-CCR1 Axis(大腸癌のSMAD4欠損によりケモカインCCL15が分泌され、腫瘍周囲にCCR1陽性腫瘍関連好中球(TAN)が集積し、肺転移が促進する)

  山本　高正, Sub-chief Examiner

  23 Mar. 2017
• ES細胞の分化誘導時における休眠状態への遷移現象の発見とそのメカニズムの解析

  池田　愛, Sub-chief Examiner

  23 Mar. 2017
• Cell Density-dependent Increase in Tyrosine-monophosphorylated ERK2 in MDCK Cells Expressing Active Ras or Raf(Ras及びRaf変異発現イヌ腎上皮細胞における、細胞密度依存性の活性型ERK2から非活性型ERK2への遷移)

  河鰭　憲幸, Sub-chief Examiner

  23 Mar. 2017
• Trametinib plus 4-methylumbelliferone exhibits antitumor effects by ERK blockade and CD44 downregulation and affects PD1 and PD-L1 in malignant pleural mesothelioma(悪性胸膜中皮腫においてトラメチニブと4－メチルウンベリフェロンは，ERKを遮断しCD44を下方制御することによって抗腫瘍効果を示し，PD1及びPD-L1の発現に影響を与える)

  長　博之, Sub-chief Examiner

  23 Mar. 2017
• Role of Ca2+ in the Stability and Function of TMEM16F and 16K(TMEM16Fと16Kの安定化と機能におけるCa2+の役割)

  石原　健司, Chief Examiner

  23 Sep. 2016

Participation in PhD Defenses (other than KU)

• A novel strategy to tag matrix metalloproteinases-positive cells for in vivo imaging of invasive and metastatic activity of tumor cells.

  Tao Zhao, Fourth Military Medical University, China, Sub-chief Examiner

  23 May 2010

Student achievements: Awards

• Poster Presentation Audience Award. 1st Prize.

  Joshua Mulele Machayo, The 20th Biostudies Student Symposium, 14 Mar. 2024
• Best Poster Presentation Award

  Joshua Mulele Machayo, The 21st International Joint Mini-symposium on Molecular and Cell Biology, 08 Jun. 2024
• Best Oral Presentation Award

  Phoung Thi Lien NGUYEN, The 21st International Joint Mini-symposium on Molecular and Cell Biology, 08 Jun. 2024
• Best Discussant Award

  Joshua Mulele Machayo, 統合放射線科学リトリート－生体内微小環境応答とDNA損傷応答の接点, 06 Mar. 2024
• Best Presentation Award

  Peter W.T. LEE, 統合放射線科学リトリート－生体内微小環境応答とDNA損傷応答の接点, 06 Mar. 2024
• 第39回井上研究奨励賞

  諏訪達也, 井上科学振興財団, 09 Dec. 2022
• 梅垣賞

  諏訪達也, 日本放射線腫瘍学会, 10 Nov. 2022
• JCA若手研究者ポスター賞

  Christalle CT Chow, 第81回日本癌学会学術総会, 01 Oct. 2022
• YIA最優秀賞.

  諏訪達也, 低酸素研究会2021, 04 Sep. 2021
• Best Oral Presentation Award, First Place.

  Christalle CT Chow, KU-NTU-TU International Symposium, 19 Dec. 2020
• 最優秀一般演題賞（査読点数第1位）

  諏訪達也, 日本放射線腫瘍学会第33回学術大会, 03 Nov. 2020
• 優秀ポスター発表賞

  Tatsuya SUWA, 第23回菅原・大西記念癌治療増感シンポジウム, 09 Feb. 2020
• 優秀研究発表賞

  Tatsuya SUWA, 日本放射線影響学会 第62回大会, 16 Nov. 2019
• 第18回 日本癌分子標的治療学会 学術総会 若手優秀演題賞

  後藤容子, 日本癌分子標的治療学会, 27 Jun. 2014
• 第23回国際癌治療増感研究会最優秀演題賞

  中島良太, 国際癌治療増感研究協会, 15 Jul. 2017
• 優秀研究発表賞

  諏訪達也, 日本放射線影響学会 第62回大会, 16 Nov. 2019
• 優秀ポスター発表賞

  諏訪達也, 第23回菅原・大西記念癌治療増感シンポジウム, 09 Feb. 2020

Part-time lecturer

• From 01 Oct. 2024, To 31 Mar. 2025

  分子生物学Ⅱ
• From 01 Apr. 2024, To 30 Sep. 2024

  原子核工学最前線

  2024年前期, 京都大学, 大学院工学研究科
• From 01 Oct. 2023, To 31 Mar. 2024

  分子生物学Ⅱ
• From 01 Oct. 2022, To 31 Mar. 2023

  分子生物学Ⅱ
• From 01 Apr. 2022, To 30 Sep. 2022

  原子核工学最前線

  2022年前期, 京都大学, 大学院工学研究科
• From 01 Apr. 2021, To 30 Sep. 2021

  生物物理学

  前期, 工学部
• From 01 Apr. 2020, To 30 Sep. 2020

  生物物理学

  前期, 工学部
• From 01 Apr. 2020, To 30 Sep. 2020

  原子核工学最前線

  前期, 工学部
• From 01 Apr. 2019, To 18 Sep. 2019

  放射線によるがん治療

  2019年前期, 東京大学, 大学院工学系研究科
• From 01 Apr. 2019, To 30 Sep. 2019

  生物物理学

  前期, 工学部
• From 01 Apr. 2019, To 30 Sep. 2019

  原子核工学最前線

  前期, 工学部
• From 01 Apr. 2018, To 30 Sep. 2018

  原子核工学最前線

  2018年前期, 京都大学, 大学院工学研究科
• From 01 Apr. 2018, To 30 Sep. 2018

  生物物理学

  2018年前期, 京都大学, 工学部

Administration

School management (title, position)

• From 01 Apr. 2023, To 31 Mar. 2025

  放射線生物研究センター センター長
• From 07 Nov. 2023, To 06 Nov. 2025

  核医学研究に関する共同利用検討小委員会
• From 01 Apr. 2023, To 31 Mar. 2025

  放射性同位元素等専門委員会 委員
• From 01 Jan. 2018, To 22 Apr. 2019

  京都大学動物実験委員会 委員
• From 01 Apr. 2019, To 31 Mar. 2021

  放射線生物研究センター長
• From 01 Jan. 2018, To 31 Mar. 2018

  京都大学動物実験委員会 委員
• From 01 Apr. 2020, To 31 Mar. 2021

  研究連携基盤運営委員会
• From 01 Apr. 2021, To 31 Mar. 2023

  放射線生物研究センター センター長
• From 01 Apr. 2021, To 31 Mar. 2023

  学生生活委員会第三小委員会 委員
• From 01 Apr. 2021, To 31 Mar. 2023

  学生生活委員会 委員