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Minato, Nagahiro

President

Minato, Nagahiro
list
    Last Updated :2025/05/27

    Basic Information

    Faculty

    • 医学部

    Academic Degree

    • 医学博士(京都大学)

    Language of Instruction

    • English

    ID,URL

    researchmap URL

    list
      Last Updated :2025/05/27

      Research

      Research Topics, Overview of the research

      • Research Topics

        1. Cancer immunology, 2. Development and signal transduction of immune system

      Papers

      • Enteroendocrine Cells Are Specifically Marked by Cell Surface Expression of Claudin-4 in Mouse Small Intestine
        Takahiro Nagatake; Harumi Fujita; Nagahiro Minato; Yoko Hamazaki
        PLOS ONE, Mar. 2014, Peer-reviewed
      • gamma delta T Cells and Their Potential for Immunotherapy
        Yan-Ling Wu; Yan-Ping Ding; Yoshimasa Tanaka; Li-Wen Shen; Chuan-He Wei; Nagahiro Minato; Wen Zhang
        INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2014, Peer-reviewed
      • Rap G protein signal in normal and disordered lymphohematopoiesis
        Nagahiro Minato
        Experimental Cell Research, 10 Sep. 2013, Peer-reviewed
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      • Comparison of γδ T cell responses and farnesyl diphosphate synthase inhibition in tumor cells pretreated with zoledronic acid
        Atif S.M. Idrees; Tomoharu Sugie; Chiyomi Inoue; Kaoru Murata-Hirai; Haruki Okamura; Craig T. Morita; Nagahiro Minato; Masakazu Toi; Yoshimasa Tanaka
        Cancer Science, May 2013, Peer-reviewed
      • Zoledronic acid-induced expansion of gamma delta T cells from early-stage breast cancer patients: effect of IL-18 on helper NK cells
        Tomoharu Sugie; Kaoru Murata-Hirai; Masashi Iwasaki; Craig T. Morita; Wen Li; Haruki Okamura; Nagahiro Minato; Masakazu Toi; Yoshimasa Tanaka
        CANCER IMMUNOLOGY IMMUNOTHERAPY, Apr. 2013, Peer-reviewed
      • Claudin-4 Deficiency Results in Urothelial Hyperplasia and Lethal Hydronephrosis
        Harumi Fujita; Yoko Hamazaki; Yumi Noda; Masanobu Oshima; Nagahiro Minato
        PLOS ONE, Dec. 2012, Peer-reviewed
      • E2A and CBP/p300 Act in Synergy To Promote Chromatin Accessibility of the Immunoglobulin kappa Locus
        Shuji Sakamoto; Kousho Wakae; Yuki Anzai; Kiyohito Murai; Nobuyuki Tamaki; Masaki Miyazaki; Kazuko Miyazaki; William J. Romanow; Tomokatsu Ikawa; Daisuke Kitamura; Itaru Yanagihara; Nagahiro Minato; Cornelis Murre; Yasutoshi Agata
        JOURNAL OF IMMUNOLOGY, Jun. 2012, Peer-reviewed
      • [PD-1 expressing T cells in leukemia].
        Y. Nakashima; N. Minato
        [Rinshō ketsueki] The Japanese journal of clinical hematology, 2012, Peer-reviewed
      • Immunosenescence and diseases: Follicular T cell response in germinal center reaction
        Nagahiro Minato
        Seikagaku, 2012, Peer-reviewed
      • Analysis and synthesis of multi-dimentional immune organ network
        Y. Takahama; N. Minato
        Seikagaku, 2012, Peer-reviewed
      • Gene Expression Profiling of Neural Stem Cells and Identification of Regulators of Neural Differentiation During Cortical Development
        Toshiyuki Ohtsuka; Hiromi Shimojo; Mitsuhiro Matsunaga; Naoki Watanabe; Kohei Kometani; Nagahiro Minato; Ryoichiro Kageyama
        STEM CELLS, Nov. 2011, Peer-reviewed
      • Gene Expression Profiling of Neural Stem Cells and Identification of Regulators of Neural Differentiation During Cortical Development
        Toshiyuki Ohtsuka; Hiromi Shimojo; Mitsuhiro Matsunaga; Naoki Watanabe; Kohei Kometani; Nagahiro Minato; Ryoichiro Kageyama
        STEM CELLS, Nov. 2011, Peer-reviewed
      • Phase I/II study of adoptive transfer of gamma delta T cells in combination with zoledronic acid and IL-2 to patients with advanced renal cell carcinoma
        Hirohito Kobayashi; Yoshimasa Tanaka; Junji Yagi; Nagahiro Minato; Kazunari Tanabe
        CANCER IMMUNOLOGY IMMUNOTHERAPY, Aug. 2011, Peer-reviewed
      • Tangential migration and proliferation of intermediate progenitors of GABAergic neurons in the mouse telencephalon
        Shengxi Wu; Shigeyuki Esumi; Keisuke Watanabe; Jing Chen; Kouichi C. Nakamura; Kazuhiro Nakamura; Kouhei Kometani; Nagahiro Minato; Yuchio Yanagawa; Kaori Akashi; Kenji Sakimura; Takeshi Kaneko; Nobuaki Tamamaki
        DEVELOPMENT, Jun. 2011, Peer-reviewed
      • Regulation of TCR V gamma 2 gene rearrangement by the helix-loop-helix protein, E2A
        Masatoshi Nozaki; Kousho Wakae; Nobuyuki Tamaki; Shuji Sakamoto; Kiyouhisa Ohnishi; Toshifumi Uejima; Nagahiro Minato; Itaru Yanagihara; Yasutoshi Agata
        INTERNATIONAL IMMUNOLOGY, May 2011, Peer-reviewed
      • SPA-1 controls the invasion and metastasis of human prostate cancer
        Yosuke Shimizu; Yoko Hamazaki; Masakazu Hattori; Keiko Doi; Naoki Terada; Takashi Kobayashi; Yoshinobu Toda; Toshinari Yamasaki; Takahiro Inoue; Yoichiro Kajita; Atsushi Maeno; Tomomi Kamba; Yoshiki Mikami; Toshiyuki Kamoto; Tomomi Yamada; Toru Kanno; Kiyotsugu Yoshikawa; Osamu Ogawa; Nagahiro Minato; Eijiro Nakamura
        CANCER SCIENCE, Apr. 2011, Peer-reviewed
      • Increased c-Myc activity and DNA damage in hematopoietic progenitors precede myeloproliferative disease in Spa-1-deficiency
        Hiroki Tanaka; Akitoshi Tamura; Miho Sekai; Yoko Hamazaki; Nagahiro Minato
        CANCER SCIENCE, Apr. 2011, Peer-reviewed
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      • A New Indicator of Favorable Prognosis in Locally Advanced Renal Cell Carcinomas: gamma delta T-Cells in Peripheral Blood
        Hirohito Kobayashi; Yoshimasa Tanaka; Hayakazu Nakazawa; Junji Yagi; Nagahiro Minato; Kazunari Tanabe
        ANTICANCER RESEARCH, Mar. 2011, Peer-reviewed
      • Expression and function of PD-1 in human gamma delta T cells that recognize phosphoantigens
        Masashi Iwasaki; Yoshimasa Tanaka; Hirohito Kobayashi; Kaoru Murata-Hirai; Hideto Miyabe; Tomoharu Sugie; Masakazu Toi; Nagahiro Minato
        EUROPEAN JOURNAL OF IMMUNOLOGY, Feb. 2011, Peer-reviewed
      • Expression and function of PD-1 in human gd T cell responses to tumor cells. Eur.
        Iwasaki, M; Tanaka, Y; Kobayashi, H; Hirai K; Sugie, T; Toi, M; Minato, N
        J. Immunol. 41(2):345-355., 2011, Peer-reviewed
      • Anti-Programmed Cell Death 1 Antibody Reduces CD4(+)PD-1(+) T Cells and Relieves the Lupus-Like Nephritis of NZB/W F1 Mice
        Shimpei Kasagi; Seiji Kawano; Taku Okazaki; Tasuku Honjo; Akio Morinobu; Saori Hatachi; Kenichiro Shimatani; Yoshimasa Tanaka; Nagahiro Minato; Shunichi Kumagai
        JOURNAL OF IMMUNOLOGY, Mar. 2010, Peer-reviewed
      • Complete Remission of Lung Metastasis Following Adoptive Immunotherapy Using Activated Autologous gamma delta T-cells in a Patient with Renal Cell Carcinoma
        Hirohito Kobayashi; Yoshimasa Tanaka; Hiroaki Shimmura; Nagahiro Minato; Kazunari Tanabe
        ANTICANCER RESEARCH, Feb. 2010, Peer-reviewed
      • Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells
        Yoshinori Katayama; Miho Sekai; Masakazu Hattori; Ichiro Miyoshi; Yoko Hamazaki; Nagahiro Minato
        BLOOD, Aug. 2009, Peer-reviewed
      • Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells
        Yoshinori Katayama; Miho Sekai; Masakazu Hattori; Ichiro Miyoshi; Yoko Hamazaki; Nagahiro Minato
        BLOOD, Aug. 2009, Peer-reviewed
      • Isolation of ON Bipolar Cell Genes via hrGFP-coupled Cell Enrichment Using the mGluR6 Promoter
        Yoshiaki Nakajima; Masaki Moriyama; Masakazu Hattori; Nagahiro Minato; Shigetada Nakanishi
        JOURNAL OF BIOCHEMISTRY, Jun. 2009, Peer-reviewed
      • Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal
        Satoru Hara; Chiaki Nakaseko; Sho Yamasaki; Masakazu Hattori; Johannes L. Bos; Yasushi Saito; Nagahiro Minato; Takashi Saito
        HEMATOLOGY, Jun. 2009, Peer-reviewed
      • Notch activation in thymic epithelial cells induces development of thymic microenvironments
        Kyoko Masuda; Wilfred T. V. Germeraad; Rumi Satoh; Manami Itoi; Tomokatsu Ikawa; Nagahiro Minato; Yoshimoto Katsura; Willem van Ewijk; Hiroshi Kawamoto
        MOLECULAR IMMUNOLOGY, May 2009, Peer-reviewed
      • Rapid alpha beta TCR-mediated responses in gamma delta T cells transduced with cancer-specific TCR genes
        A. Hiasa; H. Nishikawa; M. Hirayama; S. Kitano; S. Okamoto; H. Chono; S. S. Yu; J. Mineno; Y. Tanaka; N. Minato; I. Kato; H. Shiku
        GENE THERAPY, May 2009, Peer-reviewed
      • Spa-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis
        Nagahiro Minato; Masakazu Hattori
        CANCER SCIENCE, Jan. 2009, Peer-reviewed
      • Identification of ON bipolar cell-specific genes.
        Nakajima, Y; Moriyama, M; Hattori, M; Minato, N; Nakanishi, S
        J. Biochem, 2009, Peer-reviewed
      • Essential role of Rap signal in pre-TCR-mediated beta-selection checkpoint in alpha beta T-cell development
        Kohei Kometani; Masaki Moriyama; Yasuhiro Nakashima; Yoshinori Katayama; Shu-Fang Wang; Sho Yamasaki; Takashi Saito; Masakazu Hattori; Nagahiro Minato
        BLOOD, Dec. 2008, Peer-reviewed
      • Development of Notch-dependent T-cell leukemia by deregulated Rap1 signaling
        Shu-Fang Wang; Misayo Aoki; Yasuhiro Nakashima; Yoriko Shinozuka; Hiroki Tanaka; Masafumi Taniwaki; Masakazu Hattori; Nagahiro Minatol
        BLOOD, Mar. 2008, Peer-reviewed
      • Bone marrow pre-B expansion by SL/Kh-Bomb1 locus: Not sufficient for lymphomagenesis
        Takuya Hiratsuka; Tatsuaki Tsuruyama; Richard Kaszynski; Kohei Kometani; Nagahiro Minato; Takuro Nakamura; Keiji Tamaki; Hiroshi Hiai
        LEUKEMIA RESEARCH, Feb. 2008, Peer-reviewed
      • Human gamma delta T cells modulate the mite allergen-specific T-helper type 2-skewed immunity
        S. Korematsu; Y. Tanaka; T. Nagakura; N. Minato; T. Izumi
        CLINICAL AND EXPERIMENTAL ALLERGY, Nov. 2007, Peer-reviewed
      • T cell lineage determination precedes the initiation of TCR beta gene rearrangement
        Kyoko Masuda; Kiyokazu Kakugawa; Toshinori Nakayama; Nagahiro Minato; Yoshimoto Katsura; Hiroshi Kawamoto
        JOURNAL OF IMMUNOLOGY, Sep. 2007, Peer-reviewed
      • Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1
        Daiji Sakata; Hiroyuki Taniguchi; Shingo Yasuda; Aki Adachi-Morishima; Yoko Hamazaki; Rika Nakayama; Takashi Miki; Nagahiro Minato; Shuh Narumiya
        JOURNAL OF EXPERIMENTAL MEDICINE, Sep. 2007, Peer-reviewed
      • Specific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells: possible application to enhance T cell function
        Selgo Terawaki; Yoshimasa Tanaka; Tornokazu Nagakura; Tarnon Hayashi; Shiro Shibayama; Kaori Muroi; Taku Okazaki; Bunzo Mikami; David N. Garboczi; Tasuku Honjo; Nagahiro Minato
        INTERNATIONAL IMMUNOLOGY, Jul. 2007, Peer-reviewed
      • SMAD4-deficient intestinal tumors recruit CCR1(+) myeloid cells that promote invasion
        Takanori Kitamura; Kohei Kometani; Hiroki Hashida; Akihiro Matsunaga; Hiroyuki Miyoshi; Hisahiro Hosogi; Masahiro Aoki; Masanobu Oshima; Masakazu Hattori; Arimichi Takabayashi; Nagahiro Minato; Makoto M. Taketo
        NATURE GENETICS, Apr. 2007, Peer-reviewed
      • Safety profile and anti-tumor effects of adoptive immunotherapy using gamma-delta T cells against advanced renal cell carcinoma: a pilot study
        Hirohito Kobayashi; Yoshimasa Tanaka; Junji Yagi; Yukinari Osaka; Hayakazu Nakazawa; Takehiko Uchiyama; Nagahiro Minato; Hiroshi Toma
        CANCER IMMUNOLOGY IMMUNOTHERAPY, Apr. 2007, Peer-reviewed
      • Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin
        Yoko Hamazaki; Harumi Fujita; Takashi Kobayashi; Yongwon Choi; Hamish S. Scott; Mitsuru Matsumoto; Nagahiro Minato
        NATURE IMMUNOLOGY, Mar. 2007, Peer-reviewed
      • Clinical, immunological, and pathological aspects of operational tolerance after pediatric living-donor liver transplantation
        Takaaki Koshiba; Ying Li; Mami Takemura; Yanling Wu; Shimon Sakaguchi; Nagahiro Minato; Kathryn J. Wood; Hironori Haga; Mikiko Ueda; Shinji Uemoto
        TRANSPLANT IMMUNOLOGY, Feb. 2007, Peer-reviewed
      • Regulation of immune responses and hematopoiesis by the Rap1 signal
        Nagahiro Minato; Kohei Kometani; Masakazu Hattori
        ADVANCES IN IMMUNOLOGY, VOL 93, 2007, Peer-reviewed
      • Synthesis of pyrophosphate-containing compounds that stimulate V gamma 2V delta 2 T cells: Application to cancer immunotherapy
        Y. Tanaka; H. Kobayashi; T. Terasaki; H. Toma; A. Aruga; T. Uchiyama; K. Mizutani; B. Mikami; C. T. Morita; N. Minato
        MEDICINAL CHEMISTRY, Jan. 2007, Peer-reviewed
      • Role of SPA-1 in phenotypes of chronic myelogenous leukemia induced by BCR-ABL-expressing hematopoietic progenitors in a mouse model
        Kohei Kometani; Misayo Aoki; Shin Kawamata; Yoriko Shinozuka; Takumi Era; Masafumi Taniwaki; Masakazu Hattori; Nagahiro Minato
        CANCER RESEARCH, Oct. 2006, Peer-reviewed
      • Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens
        Yu Kato; Yoshimasa Tanaka; Mikihito Hayashi; Katsuya Okawa; Nagahiro Minato
        JOURNAL OF IMMUNOLOGY, Jul. 2006, Peer-reviewed
      • BCR/ABL and IL-3 activate Rap1 to stimulate the B-Raf/MEK/Erk and Akt signaling pathways and to regulate proliferation, apoptosis, and adhesion
        A. Jin; T. Kurosu; K. Tsuji; D. Mizuchi; A. Arai; H. Fujita; M. Hattori; N. Minato; O. Miura
        ONCOGENE, Jul. 2006, Peer-reviewed
      • Impaired T-cell differentiation in the thymus at the early stages of acute pathogenic chimeric simian-human immunodeficiency virus (SHIV) infection in contrast to less pathogenic SHIV infection
        Makiko Motohara; Kentaro Ibuki; Ariko Miyake; Yoshinori Fukazawa; Katsuhisa Inaba; Hajime Suzuki; Kyoko Masuda; Nagahiro Minato; Hiroshi Kawamoto; Tadashi Nakasone; Mitsuo Honda; Masanori Hayami; Tomoyuki Miura
        MICROBES AND INFECTION, May 2006, Peer-reviewed
      • Classification of human liver transplant recipients by their preoperative CD8(+) T cell subpopulation and its relation to outcome
        K Tanaka; K Ozawa; S Teramukai; Y Takada; H Egawa; S Kaihara; Y Fujimoto; Y Ogura; M Kasahara; M Ono; H Sato; K Takai; M Fukushima; N Minato
        LIVER TRANSPLANTATION, May 2006, Peer-reviewed
      • Rap1 signal controls B cell receptor repertoire and generation of self-reactive B1a cells
        D Ishida; L Su; A Tamura; Y Katayama; Y Kawai; SF Wang; M Taniwaki; Y Hamazaki; M Hattori; N Minato
        IMMUNITY, Apr. 2006, Peer-reviewed
      • Crystal structure and some properties of a major house dust mite allergen, Derf 2
        M Suzuki; Y Tanaka; S Korematsu; B Mikami; N Minato
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2006, Peer-reviewed
      • Prethymic T-cell development defined by the expression of paired immunoglobulin-like receptors
        K Masuda; H Kubagawa; T Ikawa; CC Chen; K Kakugawa; M Hattori; R Kageyama; MD Cooper; N Minato; Y Katsura; H Kawamoto
        EMBO JOURNAL, Dec. 2005, Peer-reviewed
      • Enhanced expression of programmed death-1 (PD-1)/PD-L1 in salivary glands of patients with Sjogren's syndrome
        M Kobayashi; S Kawano; S Hatachi; C Kurimoto; T Okazaki; Y Iwai; T Honjo; Y Tanaka; N Minato; T Komori; S Maeda; S Kumagai
        JOURNAL OF RHEUMATOLOGY, Nov. 2005, Peer-reviewed
      • Analysis of mechanism for human gamma delta T cell recognition of nonpeptide antigens
        S Yamashita; Y Tanaka; S Tsutsumi; AB Hiroyuki; N Minato; S Ihara
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2005, Peer-reviewed
      • Hes1 directly controls cell proliferation through the transcriptional repression of p27(Kip1)
        K Murata; M Hattori; N Hirai; Y Shinozuka; H Hirata; R Kageyama; T Sakai; N Minato
        MOLECULAR AND CELLULAR BIOLOGY, May 2005, Peer-reviewed
      • Thymic anlage is colonized by progenitors restricted to T, NK, and dendritic cell lineages
        K Masuda; M Itoi; T Amagai; N Minato; Y Katsura; H Kawamoto
        JOURNAL OF IMMUNOLOGY, Mar. 2005, Peer-reviewed
      • Intrathymic effect of acute pathogenic SHIV infection on T-lineage cells in newborn macaques
        H Suzuki; M Motohara; A Miyake; K Ibuki; Y Fukazawa; K Inaba; K Masuda; N Minato; H Kawamoto; M Hayami; T Miura
        MICROBIOLOGY AND IMMUNOLOGY, 2005, Peer-reviewed
      • Analyses of peripheral blood mononuclear cells in operational tolerance after pediatric living donor liver transplantation
        Y Li; T Koshiba; A Yoshizawa; Y Yonekawa; K Masuda; A Ito; M Ueda; T Mori; H Kawamoto; Y Tanaka; S Sakaguchi; N Minato; KJ Wood; K Tanaka
        AMERICAN JOURNAL OF TRANSPLANTATION, Dec. 2004, Peer-reviewed
      • Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization
        A Farina; M Hattori; J Qin; Y Nakatani; N Minato; K Ozato
        MOLECULAR AND CELLULAR BIOLOGY, Oct. 2004, Peer-reviewed
      • Rap1 and SPA-1 in hematologic malignancy
        K Kometani; D Ishida; M Hattori; N Minato
        TRENDS IN MOLECULAR MEDICINE, Aug. 2004, Peer-reviewed
      • Myeloid cells
        A Kawamoto; N Minato
        INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, Aug. 2004, Peer-reviewed
      • Aquaporin-2 trafficking is regulated by PDZ-domain containing protein SPA-1
        Y Noda; S Horikawa; T Furukawa; K Hirai; Y Katayama; T Asai; M Kuwahara; K Katagiri; T Kinashi; M Hattori; N Minato; S Sasaki
        FEBS LETTERS, Jun. 2004, Peer-reviewed
      • Pivotal role of CXCR3 in melanoma cell metastasis to lymph nodes
        K Kawada; M Sonoshita; H Sakashita; A Takabayashi; Y Yamaoka; T Manabe; K Inaba; N Minato; M Oshima; MM Taketo
        CANCER RESEARCH, Jun. 2004, Peer-reviewed
      • Specific recruitment of SPA-1 to the immunological synapse: involvement of actin-bundling protein actinin
        M Harazaki; Y Kawai; L Su; Y Hamazaki; T Nakahata; N Minato; M Hattori
        IMMUNOLOGY LETTERS, Apr. 2004, Peer-reviewed
      • Identification of the earliest prethymic T-cell progenitors in murine fetal blood
        T Ikawa; K Masuda; M Lu; N Minato; Y Katsura; H Kawamoto
        BLOOD, Jan. 2004, Peer-reviewed
      • Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice
        T Okazaki; Y Tanaka; R Nishio; T Mitsuiye; A Mizoguchi; J Wang; M Ishida; H Hiai; A Matsumori; N Minato; T Honjo
        NATURE MEDICINE, Dec. 2003, Peer-reviewed
      • Recognition mechanism of non-peptide antigens by human gamma delta T cells
        S Yamashita; Y Tanaka; M Harazaki; B Mikami; N Minato
        INTERNATIONAL IMMUNOLOGY, Nov. 2003, Peer-reviewed
      • TAK bipotent progenitors in the thymus retain the potential to generate dendritic cells
        HQ Shen; M Lu; T Ikawa; K Masuda; K Ohmura; N Minato; Y Katsura; H Kawamoto
        JOURNAL OF IMMUNOLOGY, Oct. 2003, Peer-reviewed
      • Rap1 GTPase: Functions, regulation, and malignancy
        M Hattori; N Minato
        JOURNAL OF BIOCHEMISTRY, Oct. 2003, Peer-reviewed
      • Activation of CEA-CAM-1-mediated cell adhesion via CD98: involvement of PKC delta
        K Kakugawa; M Hattori; N Beauchemin; N Minato
        FEBS LETTERS, Sep. 2003, Peer-reviewed
      • Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice
        D Ishida; K Kometani; HL Yang; K Kakugawa; K Masuda; K Iwai; M Suzuki; S Itohara; T Nakahata; H Hiai; H Kawamoto; M Hattori; N Minato
        CANCER CELL, Jul. 2003, Peer-reviewed
      • Requirement of species-specific interactions for the activation of human gamma delta T cells by pamidronatel
        Y Kato; Y Tanaka; H Tanaka; S Yamashita; N Minato
        JOURNAL OF IMMUNOLOGY, Apr. 2003, Peer-reviewed
      • Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2
        K Yamanaka; H Ishikawa; Y Megumi; F Tokunaga; M Kanie; TA Rouault; Morishima, I; N Minato; K Ishimori; K Iwai
        NATURE CELL BIOLOGY, Apr. 2003, Peer-reviewed
      • AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1
        L Su; M Hattori; M Moriyama; N Murata; M Harazaki; K Kaibuchi; N Minato
        JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2003, Peer-reviewed
      • Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues
        M Ishida; Y Iwai; Y Tanaka; T Okazaki; GJ Freeman; N Minato; T Honjo
        IMMUNOLOGY LETTERS, Oct. 2002, Peer-reviewed
      • Rap1 functions as a key regulator of T-cell and antigen-presenting cell interactions and modulates T-cell responses
        K Katagiri; M Hattori; N Minato; T Kinashi
        MOLECULAR AND CELLULAR BIOLOGY, Feb. 2002, Peer-reviewed
      • Essential contribution of germline-encoded lysine residues in J gamma 1.2 segment to the recognition of nonpeptide antigens by human gamma delta T cells
        F Miyagawa; Y Tanaka; S Yamashita; B Mikami; K Danno; M Uehara; N Minato
        JOURNAL OF IMMUNOLOGY, Dec. 2001, Peer-reviewed
      • Targeting of tumor cells for human gamma delta T cells by nonpeptide antigens
        Y Kato; Y Tanaka; F Miyagawa; S Yamashita; N Minato
        JOURNAL OF IMMUNOLOGY, Nov. 2001, Peer-reviewed
      • The von Hippel-Lindau tumor suppressor protein mediates ubiquitination of activated atypical protein kinase C
        H Okuda; K Saitoh; S Hirai; K Iwai; Y Takaki; M Baba; N Minato; S Ohno; T Shuin
        JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2001, Peer-reviewed
      • NEDD8 recruits E2-ubiquitin to SCF E3 ligase
        T Kawakami; T Chiba; T Suzuki; K Iwai; K Yamanaka; N Minato; H Suzuki; N Shimbara; Y Hidaka; F Osaka; M Omata; K Tanaka
        EMBO JOURNAL, Aug. 2001, Peer-reviewed
      • Essential requirement of antigen presentation by monocyte lineage cells for the activation of primary human gamma delta T cells by aminobisphosphonate antigen
        F Miyagawa; Y Tanaka; S Yamashita; N Minato
        JOURNAL OF IMMUNOLOGY, May 2001, Peer-reviewed
      • CD98 induces LFA-1-mediated cell adhesion in lymphoid cells via activation of Rap1
        K Suga; K Katagiri; T Kinashi; M Harazaki; T Iizuka; M Hattori; N Minato
        FEBS LETTERS, Feb. 2001, Peer-reviewed
      • Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
        H Nishimura; T Okazaki; Y Tanaka; K Nakatani; M Hara; A Matsumori; S Sasayama; A Mizoguchi; H Hiai; N Minato; T Honjo
        SCIENCE, Jan. 2001, Peer-reviewed
      • Distribution of the 4F2 light chain, LATI, in the mouse brain
        T Kageyama; T Imura; A Matsuo; N Minato; S Shimohama
        NEUROREPORT, Nov. 2000, Peer-reviewed
      • The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrier
        T Kageyama; M Nakamura; A Matsuo; Y Yamasaki; Y Takakura; M Hashida; Y Kanai; M Naito; T Tsuruo; N Minato; S Shimohama
        BRAIN RESEARCH, Oct. 2000, Peer-reviewed
      • C8/119S mutation of major mite allergen Derf-2 leads to degenerate secondary structure and molecular polymerization and induces potent and exclusive Th1 cell differentiation
        S Korematsu; Y Tanaka; S Hosoi; S Koyanagi; T Yokota; B Mikami; N Minato
        JOURNAL OF IMMUNOLOGY, Sep. 2000, Peer-reviewed
      • Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice
        H Nishimura; T Honjo; N Minato
        JOURNAL OF EXPERIMENTAL MEDICINE, Mar. 2000, Peer-reviewed
      • Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase
        K Katagiri; M Hattori; N Minato; S Irie; K Takatsu; T Kinashi
        MOLECULAR AND CELLULAR BIOLOGY, Mar. 2000, Peer-reviewed
      • Selective expression and function of granzyme D in lymphohematopoietic stromal cells
        A Yokoi; T Kina; N Minato
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 1999, Peer-reviewed
      • Stabilization of iron regulatory protein 2, IRP2, by aluminum
        K Yamanaka; N Minato; K Iwai
        FEBS LETTERS, Nov. 1999, Peer-reviewed
      • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
        H Nishimura; M Nose; H Hiai; N Minato; T Honjo
        IMMUNITY, Aug. 1999, Peer-reviewed
      • Rap1 GTPase-activating protein SPA-1 negatively regulates cell adhesion
        N Tsukamoto; M Hattori; HL Yang; JL Bos; N Minato
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 1999, Peer-reviewed
      • The bHLH gene Hes1 is essential for expansion of early T cell precursors
        K Tomita; M Hattori; E Nakamura; S Nakanishi; N Minato; R Kageyama
        GENES & DEVELOPMENT, May 1999, Peer-reviewed
      • 4F2 (CD98) heavy chain is associated covalently with an amino acid transporter and controls intracellular trafficking and membrane topology of 4F2 heterodimer
        E Nakamura; M Sato; HL Yang; F Miyagawa; M Harasaki; K Tomita; S Matsuoka; A Noma; K Iwai; N Minato
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 1999, Peer-reviewed
      • Mutational analysis of superantigen activity responsible for the induction of skin erythema by streptococcal pyrogenic exotoxin c
        J Yamaoka; E Nakamura; Y Takeda; S Imamura; N Minato
        INFECTION AND IMMUNITY, Oct. 1998, Peer-reviewed
      • Immunological studies on PD-1-deficient mice: implication of PD-1 as a negative regulator for B cell responses
        H Nishimura; N Minato; T Nakano; T Honjo
        INTERNATIONAL IMMUNOLOGY, Oct. 1998, Peer-reviewed
      • Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2 - Segregate expression profiles from a rap1GAP gene product
        H Kurachi; Y Wada; N Tsukamoto; M Maeda; H Kubota; M Hattori; K Iwai; N Minato
        JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 1997, Peer-reviewed
      • Involvement of NK1(+)CD4(-)CD8(-) alpha beta T cells and endogenous IL-4 in non-MHC-restricted rejection of embryonal carcinoma in genetically resistant mice
        E Nakamura; H Kubota; M Sato; T Sugie; O Yoshida; N Minato
        JOURNAL OF IMMUNOLOGY, Jun. 1997, Peer-reviewed
      • Mitogen-inducible SIPA1 is mapped to the conserved syntenic groups of chromosome 19 in mouse and chromosome 11q13.3 centromeric to BCL1 in human
        Y Wada; H Kubota; M Maeda; M Taniwaki; M Hattori; S Imamura; K Iwai; N Minato
        GENOMICS, Jan. 1997, Peer-reviewed
      • Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4(-)CD8(-)) thymocytes
        H Nishimura; Y Agata; A Kawasaki; M Sato; S Imamura; N Minato; H Yagita; T Nakano; T Honjo
        INTERNATIONAL IMMUNOLOGY, May 1996, Peer-reviewed
      • NK 1+ CD4- CD8- αß T Cells in the Peritoneal Cavity: Specific T Cell Receptor-Mediated Cytotoxicity and Selective IFN-γ Production Against B Cell Leukemia and Myeloma Cells
        T. Sugie; H. Kubota; M. Sato; E. Nakamura; M. Imamura; N. Minato
        Journal of Immunology, 1996, Peer-reviewed
      • Regulatory mechanisms of lymphocyte proliferation: roles of Spa-1 gene
        N. Minato
        Human cell : official journal of Human Cell Research Society, 1996, Peer-reviewed
      • DECREASES OF CD4-POSITIVE AND CD8-POSITIVE T-LYMPHOCYTES IN RETIRED CHROMATE WORKERS
        T TANIGAWA; S ARAKI; T ARAKI; N MINATO; K YOKOYAMA
        AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, Jun. 1995, Peer-reviewed
      • MOLECULAR-CLONING OF A NOVEL MITOGEN-INDUCIBLE NUCLEAR-PROTEIN WITH A RAN GTPASE-ACTIVATING DOMAIN THAT AFFECTS CELL-CYCLE PROGRESSION
        M HATTORI; N TSUKAMOTO; MSA NUREKAMAL; B RUBINFELD; K IWAI; H KUBOTA; H MARUTA; N MINATO
        MOLECULAR AND CELLULAR BIOLOGY, Jan. 1995, Peer-reviewed
      • PULMONARY-HYPERTENSION IN SYSTEMIC LUPUS-ERYTHEMATOSUS - A REPORT OF AN AUTOPSIED CASE
        M SATO; H OKAZAKI; H OKAMOTO; A OHTAKA; H SHIMIZU; N MINATO; S KANO
        INTERNAL MEDICINE, Sep. 1994, Peer-reviewed
      • INVOLVEMENT OF 4F2 ANTIGEN EXPRESSED ON THE MHC-NEGATIVE TARGET-CELLS IN THE RECOGNITION OF MURINE CD3+CD4-CD8- ALPHA-BETA (V(ALPHA)4/V(BETA)2) T-CELLS
        H KUBOTA; M SATO; Y OGAWA; K IWAI; M HATTORI; T YOSHIDA; N MINATO
        INTERNATIONAL IMMUNOLOGY, Sep. 1994, Peer-reviewed
      • T cell development and selection in extrathymic environments
        H. Kubota; N. Minato
        Nippon rinsho. Japanese journal of clinical medicine, 1994, Peer-reviewed
      • ADULT STILLS DISEASE WITH SJOGRENS-SYNDROME SUCCESSFULLY TREATED WITH INTRAVENOUS PULSE METHYLPREDNISOLONE AND ORAL CYCLOPHOSPHAMIDE
        M SATO; A TAKEDA; H HONZU; N SAKU; N MINATO; S KANO
        INTERNAL MEDICINE, Sep. 1993, Peer-reviewed
      • DECREASE OF CD4-POSITIVE T-LYMPHOCYTES IN WORKERS EXPOSED TO BENZIDINE AND BETA-NAPHTHYLAMINE
        S ARAKI; T TANIGAWA; S ISHIZU; N MINATO
        ARCHIVES OF ENVIRONMENTAL HEALTH, Jul. 1993, Peer-reviewed
      • Giant cell arteritis and polymyalgia rheumatic presenting as subclavian artery obstraction
        M. Sato; A. Takeda; S. Hagiwara; M. Mochizuki; N. Minato; K. Saito; S. Kano
        Ryumachi, 1993, Peer-reviewed
      • A case report - Pulmonary cryptococcosis associated with systemic lupus erythematosus and review of 44 cases in Japan
        M. Sato; N. Saku; A. Takeda; N. Suzuki; T. Saito; N. Minato; K. Saito; S. Kano
        Ryumachi, 1993, Peer-reviewed
      • CD3+4-8- ALPHA-BETA-T-CELL POPULATION WITH BIASED T-CELL RECEPTOR V-GENE USAGE - PRESENCE IN BONE-MARROW AND POSSIBLE INVOLVEMENT OF IL-3 FOR THEIR EXTRATHYMIC DEVELOPMENT
        H KUBOTA; H OKAZAKI; M ONUMA; S KANO; M HATTORI; N MINATO
        JOURNAL OF IMMUNOLOGY, Aug. 1992, Peer-reviewed
      • INTERLEUKIN-7 PREFERENTIALLY SUPPORTS THE GROWTH OF GAMMA-DELTA T-CELL RECEPTOR-BEARING T-CELLS FROM FETAL THYMOCYTES INVITRO
        Y WATANABE; T SUDO; N MINATO; A OHNISHI; Y KATSURA
        INTERNATIONAL IMMUNOLOGY, Nov. 1991, Peer-reviewed
      • A DECREASE IN LEU-11A NEGATIVE LYMPHOCYTES IN RELATION TO NATURAL-KILLER-CELL ACTIVITY IN CHROMATE WORKERS
        T TANIGAWA; S ARAKI; T ARAKI; N MINATO
        BRITISH JOURNAL OF INDUSTRIAL MEDICINE, Mar. 1991, Peer-reviewed
      • A case of primary Sjogren's syndrome presenting as osteomalacia secondary to renal tubular acidosis
        H. Okazaki; S. Muto; N. Kanai; H. Shimizu; J. Masuyama; N. Minato; M. Sumiya; Y. Asano; S. Kano
        Ryumachi, 1991, Peer-reviewed
      • HIGH-MOLECULAR-WEIGHT LY-5 ISOFORMS EXPRESSED ON T-CELLS - ACTIVATION-DEPENDENT EXPRESSION
        Y OGAWA; H OKAZAKI; T SUDO; N OHNO; M ITOH; M HATTORI; M IIZUKA; N MINATO
        INTERNATIONAL IMMUNOLOGY, Jan. 1991, Peer-reviewed
      • IDENTIFICATION AND GENE CLONING OF A NEW PHOSPHATIDYLINOSITOL-LINKED ANTIGEN EXPRESSED ON MATURE LYMPHOCYTES - DOWN-REGULATION BY LYMPHOCYTE-ACTIVATION
        H KUBOTA; H OKAZAKI; M ONUMA; S KANO; M HATTORI; N MINATO
        JOURNAL OF IMMUNOLOGY, Dec. 1990, Peer-reviewed
      • ANALYSIS OF NATURAL-KILLER ACTIVITY AND NATURAL-KILLER-CELL SUBSETS IN PATIENTS WITH BLADDER-CANCER
        T MORITA; A TOKUE; N MINATO
        CANCER IMMUNOLOGY IMMUNOTHERAPY, Nov. 1990, Peer-reviewed
      • NATURAL-KILLER-CELL ACTIVITY IN WORKERS EXPOSED TO BENZIDINE AND BETA-NAPHTHYLAMINE
        T TANIGAWA; S ARAKI; S ISHIZU; T MORITA; H OKAZAKI; N MINATO
        BRITISH JOURNAL OF INDUSTRIAL MEDICINE, May 1990, Peer-reviewed
      • EXPRESSION OF MURINE IL-2-RECEPTOR BETA-CHAIN ON THYMIC AND SPLENIC LYMPHOCYTE SUBPOPULATIONS AS REVEALED BY THE IL-2-INDUCED PROLIFERATIVE RESPONSE IN HUMAN IL-2-RECEPTOR ALPHA-CHAIN TRANSGENIC MICE
        M HATTORI; H OKAZAKI; Y ISHIDA; M ONUMA; S KANO; T HONJO; N MINATO
        JOURNAL OF IMMUNOLOGY, May 1990, Peer-reviewed
      • ISOLATION AND EXPRESSION OF THE FULL-LENGTH CDNA-ENCODING CD59 ANTIGEN OF HUMAN-LYMPHOCYTES
        R SAWADA; K OHASHI; H ANAGUCHI; H OKAZAKI; M HATTORI; N MINATO; M NARUTO
        DNA AND CELL BIOLOGY, Apr. 1990, Peer-reviewed
      • A case of mixed connective tissue disease exacerbated by griseofulvin complicating aseptic meningo-encephalitis and disseminated intravascular coagulation
        H. Okazaki; M. Hatakeyama; M. Mori; N. Minato; M. Sumiya; S. Kano
        Ryumachi, 1990, Peer-reviewed
      • PROLIFERATIVE RESPONSIVENESS OF B-CELLS FROM AUTOIMMUNE NZB MICE TO ANTI-IMMUNOGLOBULIN AND INTERLEUKIN-4
        M HATAKEYAMA; N MINATO; S KANO
        CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Dec. 1989, Peer-reviewed
      • IL-7 PROMOTES THYMOCYTE PROLIFERATION AND MAINTAINS IMMUNOCOMPETENT THYMOCYTES BEARING ALPHA-BETA-T-CELL OR GAMMA-DELTA-T-CELL RECEPTORS INVITRO - SYNERGISM WITH IL-2
        H OKAZAKI; M ITO; T SUDO; M HATTORI; S KANO; Y KATSURA; N MINATO
        JOURNAL OF IMMUNOLOGY, Nov. 1989, Peer-reviewed
      • EXPANSION OF NATURAL-KILLER CELLS BUT NOT T-CELLS IN HUMAN INTERLEUKIN-2 INTERLEUKIN-2 RECEPTOR (TAC) TRANSGENIC MICE
        Y ISHIDA; M NISHI; O TAGUCHI; K INABA; M HATTORI; N MINATO; M KAWAICHI; T HONJO
        JOURNAL OF EXPERIMENTAL MEDICINE, Oct. 1989, Peer-reviewed
      • Developmental regulation of the extrathymic differentiation potential of the progenitor cells for T cell lineage
        Masakazu Hattori; Tetsuo Sudo; Hisao Izawa; Shogo Kano; Nagahiro Minato
        International Immunology, May 1989, Peer-reviewed
      • Immune dysfunctions and activation of natural killer cells in human IL-2 and IL-2/IL-2 receptor L-chain transgenic mice
        Y. Ishida; M. Nishi; O. Taguchi; K. Inaba; N. Minato; M. Kawaichi; T. Honjo
        Cold Spring Harbor Symposia on Quantitative Biology, 1989, Peer-reviewed
      • Effects of the deregulated expression of human interleukin-2 in transgenic mice
        Yasumasa Ishida; Masashi Kawaichi; Tasuku Honjo; Osamu Taguchi; Kayo Inaba; Nagahiro Minato; Miyuki Nishi
        International Immunology, 1989, Peer-reviewed
      • Complementary DNA sequence and deduced peptide sequence for CD59/MEM-43 antigen, the human homologue of murine lymphocyte antigen Ly-6C
        R. Sawada; K. Ohashi; K. Okano; M. Hattori; N. Minato; M. Naruto
        Nucleic Acids Research, 1989, Peer-reviewed
      • Two types of antibodies inhibiting interleukin-2 production by normal lymphocytes in patients with systemic lupus erythematosus
        J. Miyagi; N. Minato; M. Sumiya; T. Kasahara; S. Kano
        Arthritis and Rheumatism, 1989, Peer-reviewed
      • DIFFERENTIATION INVITRO OF T3+ LARGE GRANULAR LYMPHOCYTES WITH CHARACTERISTIC CYTO-TOXIC ACTIVITY FROM AN ISOLATED HEMATOPOIETIC PROGENITOR COLONY
        N MINATO; M HATTORI; T SUDO; S KANO; Y MIURA; J SUDA; T SUDA
        JOURNAL OF EXPERIMENTAL MEDICINE, Mar. 1988, Peer-reviewed
      • Immunological abnormalities in human interleukin-2 or interleukin-2/interleukin-2 receptor L chain transgenic mice.
        Y. Ishida; M. Nishi; O. Taguchi; K. Inaba; N. Minato; M. Kawaichi; T. Honjo
        Princess Takamatsu symposia, 1988, Peer-reviewed
      • Pulmonary involvement in mixed connective tissue disease
        H. Kawamura; H. Kobayashi; M. Hatakeyama; N. Minato; M. Sumiya; S. Kitamura; S. Kano
        Ryumachi, 1988, Peer-reviewed
      • Characterization of human peripheral blood lymphocytes cultured with recombinant interleukin 2
        T. Morita; N. Minato; A. Tokue; Y. Yonese
        Japanese Journal of Urology, 1988, Peer-reviewed
      • SELECTIVE IMPAIRMENT OF ALPHA-INTERFERON-MEDIATED NATURAL-KILLER AUGMENTATION IN SJOGRENS-SYNDROME - DIFFERENTIAL-EFFECTS OF ALPHA-INTERFERON, GAMMA-INTERFERON, AND INTERLEUKIN-2 ON CYTOLYTIC ACTIVITY
        A TAKEDA; N MINATO; S KANO
        CLINICAL AND EXPERIMENTAL IMMUNOLOGY, Nov. 1987, Peer-reviewed
      • INVIVO DISTRIBUTION OF RECOMBINANT INTERLEUKIN-2-ACTIVATED AUTOLOGOUS LYMPHOCYTES ADMINISTERED BY INTRAARTERIAL INFUSION IN PATIENTS WITH RENAL-CELL CARCINOMA
        T MORITA; Y YONESE; N MINATO
        JOURNAL OF THE NATIONAL CANCER INSTITUTE, Mar. 1987, Peer-reviewed
      • Generation of continuous large granular lymphocyte lines by interleukin 2 from the spleen cells of mice infected with Moloney leukemia virus. Involvement of interleukin 3
        M. Hattori; T. Udo; M. Iizuka; S. Kobayashi; S. Nishio; S. Kano; N. Minato
        Journal of Experimental Medicine, 1987, Peer-reviewed
      • Il-1 in host anti-tumor mechanisms
        N. Minato
        Japanese Journal of Cancer and Chemotherapy, 1987, Peer-reviewed
      • Evaluation of lymphocyte subpopulations in patients with bladder cancer: a study with monoclonal antibodies.
        T. Morita; Y. Yonese; N. Minato
        Acta Urologica Japonica, 1987, Peer-reviewed
      • A RECOMBINANT MURINE GRANULOCYTE MACROPHAGE (GM) COLONY-STIMULATING FACTOR DERIVED FROM AN INDUCER T-CELL LINE (IH5.5) - FUNCTIONAL RESTRICTION TO GM PROGENITOR CELLS
        S KAJIGAYA; T SUDA; J SUDA; M SAITO; Y MIURA; M IIZUKA; S KOBAYASHI; N MINATO; T SUDO
        JOURNAL OF EXPERIMENTAL MEDICINE, Oct. 1986, Peer-reviewed
      • MECHANISMS OF LYMPHOCYTE ADHESION TO HUMAN VASCULAR ENDOTHELIAL-CELLS IN CULTURE - LYMPHOCYTE-T ADHESION TO ENDOTHELIAL-CELLS THROUGH ENDOTHELIAL HLA-DR ANTIGENS INDUCED BY GAMMA INTERFERON
        J MASUYAMA; N MINATO; S KANO
        JOURNAL OF CLINICAL INVESTIGATION, May 1986, Peer-reviewed
      • Expression and rearrangement of the α, β, and γ chain genes of the T cell receptor in cloned murine large granular lymphocyte lines
        K. Ikuta; M. Hattori; K. Wake; S. Kano; T. Honjo; J. Yodoi; N. Minato
        Journal of Experimental Medicine, 1986, Peer-reviewed
      • TCGF (IL 2)-receptor inducing factor(s). I. Regulation of IL 2 receptor on a natural killer-like cell line (YT cells)
        J. Yodoi; K. Teshigawara; T. Nikaido; K. Fukui; T. Noma; T. Honjo; M. Takigawa; M. Sasaki; N. Minato; M. Tsudo
        Journal of Immunology, 1985, Peer-reviewed
      • REGULATION OF THE GROWTH AND FUNCTIONS OF CLONED MURINE LARGE GRANULAR LYMPHOCYTE LINES BY RESIDENT MACROPHAGES
        N MINATO; T AMAGAI; J YODOI; T DIAMANSTEIN; S KANO
        JOURNAL OF EXPERIMENTAL MEDICINE, 1985, Peer-reviewed
      • An anti-T3 autoantibody in a case of chronic thyroiditis associated with Sjögren syndrome and systemic lupus erythematosus
        K. Ando; K. Saito; T. Takai; K. Yamamoto; T. Kuzuya; S. Yoshida; A. Takeda; N. Minato; S. Kano
        [Zasshi] Journal. Nihon Naika Gakkai, 1984, Peer-reviewed
      • INVITRO POTENTIATION OF HUMAN NATURAL-KILLER CELL-ACTIVITY BY A STREPTOCOCCAL PREPARATION, OK-432 - INTERFERON AND INTERLEUKIN-2 PARTICIPATION IN THE STIMULATION WITH OK-432
        H WAKASUGI; T KASAHARA; N MINATO; J HAMURO; M MIYATA; Y MORIOKA
        JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1982, Peer-reviewed
      • STUDIES OF THE FUNCTIONS OF NATURAL-KILLER INTERFERON SYSTEM IN PATIENTS WITH SJOGREN SYNDROME
        N MINATO; A TAKEDA; S KANO; F TAKAKU
        JOURNAL OF CLINICAL INVESTIGATION, 1982, Peer-reviewed
      • ROLE OF VIRUS-REPLICATING T-CELLS IN THE SUPPRESSION OF DELAYED-TYPE HYPERSENSITIVITY
        Y KATSURA; N MINATO; S NISHIKAWA
        JOURNAL OF IMMUNOLOGY, 1981, Peer-reviewed
      • TRYPANOSOMA-CRUZI - CORRELATION OF RESISTANCE AND SUSCEPTIBILITY IN INFECTED INBRED MICE WITH THE INVIVO PRIMARY ANTIBODY-RESPONSE TO SHEEP RED-BLOOD-CELLS
        HB TANOWITZ; N MINATO; R LALONDE; M WITTNER
        EXPERIMENTAL PARASITOLOGY, 1981, Peer-reviewed
      • ON THE HETEROGENEITY OF MURINE NATURAL-KILLER CELLS
        N MINATO; L REID; BR BLOOM
        JOURNAL OF EXPERIMENTAL MEDICINE, 1981, Peer-reviewed
      • Interferon, NK cells and persistent virus infection.
        N. Minato; L. Reid; A. Neighbour; B.R. Bloom; J. Holland
        Annals of the New York Academy of Sciences, 1980, Peer-reviewed
      • AUGMENTATION OF DELAYED-TYPE HYPERSENSITIVITY BY VESICULAR STOMATITIS-VIRUS INFECTION IN MICE
        Y KATSURA; M TAKAOKI; Y KONO; N MINATO
        JOURNAL OF IMMUNOLOGY, 1980, Peer-reviewed
      • MODE OF REGULATION OF NATURAL-KILLER CELL-ACTIVITY BY INTERFERON
        N MINATO; L REID; H CANTOR; P LENGYEL; BR BLOOM
        JOURNAL OF EXPERIMENTAL MEDICINE, 1980, Peer-reviewed
      • Mechanism of rejection of virus persistently infected tumor cells by athymic nude mice
        N. Minato; B.R. Bloom; C. Jones; J. Holland; L.M. Reid
        Journal of Experimental Medicine, 1979, Peer-reviewed
      • Virus-replicating T cells in the immune response of mice. III. Role of vesicular stomatitis virus-replicating T cells in the antibody response
        N. Minato; Y. Katsura
        Journal of Experimental Medicine, 1978, Peer-reviewed
      • Virus-replicating T cells in the immune response of mice. II. Characterization of T cells capable of replicating vesicular stomatitis virus
        N. Minato; Y. Katsura
        Journal of Experimental Medicine, 1978, Peer-reviewed
      • Virus replicating T cells in the immune response of mice. I. Virus plaque assay of the lymphocytes reactive to sheep erythrocytes
        N. Minato; Y. Katsura
        Journal of Experimental Medicine, 1977, Peer-reviewed
      • Detection of tuberculin reactive cells with virus plaque assay
        Y. Katsura; N. Minato
        JAP.J.TUBERC.CHEST DIS., 1976, Peer-reviewed
      • Enumeration of antigen reactive T cells against sheep erythrocytes by the virus plaque assay
        N. Minato; Y. Katsura
        Japanese Journal of Microbiology, 1976, Peer-reviewed

      Misc.

      • Claudin-4 induction by E-protein activity in later stages of CD4/8 double-positive thymocytes to increase positive selection efficiency
        Yohei Kawai; Yoko Hamazaki; Harumi Fujita; Akikazu Fujita; Takehito Sato; Mikio Furuse; Toyoshi Fujimoto; Anton M. Jetten; Yasutoshi Agata; Nagahiro Minato
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2011, Peer-reviewed
      • Gene expression profiling of neural stem cells and identification of regulators of neural differentiation during cortical development. sponses.
        大塚俊之; 下條博美; 松永充博; 渡邊直希; 米谷耕平; 湊長博; 影山龍一郎
        第34回日本分子生物学会年会, 横浜, 2月13日-12月16日, 2011., 2011, Peer-reviewed
      • Claudin-4 is induced in thymocytes of late CD4/CD8 double positive stage by E2A and promotes abT cell receptor–mediated positive selection.
        Kawai. K; Hamazaki, Y; Fujita, H; Fujita, A; Sato, T; Moriwaki, K; Furuse, M; Fujimoto, T; Agata, Y; Minato, N
        Proc. Nat. Acad. Sci. USA. 108(10):4075-4080., 2011, Peer-reviewed
      • PD-1(+) memory phenotype CD4(+) T cells expressing C/EBP alpha underlie T cell immunodepression in senescence and leukemia
        Kenichiro Shimatani; Yasuhiro Nakashima; Masakazu Hattori; Yoko Hamazaki; Nagahiro Minato
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 2009, Peer-reviewed
        Access this misc :
      • The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors
        David Yin-Wei Lin; Yoshimasa Tanaka; Masashi Iwasaki; Apostolos G. Gittis; Hua-Poo Su; Bunzo Mikami; Taku Okazaki; Tasuku Honjo; Nagahiro Minato; David N. Garboczi
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 2008, Peer-reviewed
      • Programmed cell death 1 ligand 1 and tumor-infiltrating CD8(+) T lymphocytes are prognostic factors of human ovarian cancer
        Junzo Hamanishi; Masaki Mandai; Masashi Iwasaki; Taku Okazaki; Yoshimasa Tanaka; Ken Yamaguchi; Toshihiro Higuchi; Haruhiko Yagi; Kenji Takakura; Nagahiro Minato; Tasuku Honjo; Shingo Fujii
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 2007, Peer-reviewed
      • Pyramidal neurons of upper cortical layers generated by NEX-positive progenitor cells in the subventricular zone
        SX Wu; S Goebbels; K Nakamura; K Nakamura; K Kometani; N Minato; T Kaneko; KA Nave; N Tamamaki
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 2005, Peer-reviewed
      • Impaired T cell differentiation in the thymus at the early stages of acute pathogenic SHIV infection in monkeys in comparison to low pathogenic SHIV infection.
        Motohara M; Ibuki K; Miyake A; Fukazawa Y; Inaba K; Suzuki H; Masuda K; Minato N; Kawamoto H; Nakasone T; Honda M; Hayami M; Miura T
        23rd annual Symposium on Nonhuman Primate Models for AIDS, September 21-24, 2005, Oregon, 2005, Peer-reviewed
      • Analysis of peripheral blood mononuclear cells in operational tolerance after livingdonor \nliver transplantation.
        Li Ying; Koshiba Takaaki; Yosizawa Atushi; Ito Atushi; Egawa Hiroto; Sakaguchi Shimon; Minato Nagahiro; Wood Kathryn; Tanaka Kouichi
        第34 回日本免疫学会学術集会（2004.12.1－3. 札幌）, 2004, Peer-reviewed
      • Antigen-driven T cell anergy and defective memory T cell response via deregulated Rap1 activation in SPA-1-deficient mice
        D Ishida; HL Yang; K Masuda; K Uesugi; H Kawamoto; M Hattori; N Minato
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 2003, Peer-reviewed
      • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
        Y Iwai; M Ishida; Y Tanaka; T Okazaki; T Honjo; N Minato
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 2002, Peer-reviewed
      • Identification of the von Hippel-Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex
        K Iwai; K Yamanaka; T Kamura; N Minato; RC Conaway; JW Canaway; RD Klausner; A Pause
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 1999, Peer-reviewed
      • Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins
        K Iwai; SK Drake; NB Wehr; AM Weissman; T LaVaute; N Minato; RD Klausner; RL Levine; TA Rouault
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Apr. 1998, Peer-reviewed
      • CYTOPROTECTIVE EFFECT OF CD59 ANTIGEN ON XENOTRANSPLANTATION IMMUNITY
        T AKAMI; R SAWADA; N MINATO; M NARUTO; A YAMADA; J IMANISHI; M MITSUO; NAKAI, I; M OKAMOTO; H NAKAJIMA; K ARAKAWA; T OKA
        TRANSPLANTATION PROCEEDINGS, Apr. 1992, Peer-reviewed
      • INFLUENCE OF ANTI-MOUSE INTERFERON SERUM ON THE GROWTH AND METASTASIS OF TUMOR-CELLS PERSISTENTLY INFECTED WITH VIRUS AND OF HUMAN PROSTATIC TUMORS IN ATHYMIC NUDE-MICE
        LM REID; N MINATO; GRESSER, I; J HOLLAND; A KADISH; BR BLOOM
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, Peer-reviewed

      Presentations

      • Immunotherapy using gamma-delta T cells
        Science in Japan Forum, 2011, 文科省
      • PD-1 expressing T cells
        日本血液学会シンポジウム, 2011, 日本血液学会
      • 免疫老化について
        抗加齢医学学会シンポジウム, 2010, 抗加齢医学学会
      • Human gd T cells and Cancer Immunotherapy
        International Symposium on Cancer Biology, 2010, International Society of Cancer Biology
      • 免疫老化
        産総研シンポジウム, 2010, 産総研
      • Human gd T cells
        Wohan Medical School Symposium, 2009, Wohan University
      • Cancer Immunotherapy
        日本免疫学会シンポジウム, 2009, 日本免疫学会
      • Immunosenescence
        KTCC International Symposium, 2009, KTCC

      Industrial Property Rights

      • 特願International application No. PCT/JP2007/54052, Polymerized extracellular domain of functional cell surface molecules
        Tanaka Y; Nagahiro M
      • 特開Immunopotentiative composition, European Patent Patent No. 2243493
        Tanaka Y; Minato N
      • 特開特許第4409430号, 免疫賦活組成物
        Honjo T; Minato N; Iwai K
      • 特開US Patent No.: 6406886, DNA encoding SPA-1 protein
        Hattori M; Kubota K; Minato N
      • 特開US Patent No.: 5998585, Antibodies to the cell division protein SPA-1
        Hattori M; Minato N

      External funds: Kakenhi

      • The mechanism of CML leukemia progenitor cells eradication uncovered by Sipa1 deficiency
        Grant-in-Aid for JSPS Fellows
        Basic Section 49070:Immunology-related
        Kyoto University
        湊 長博
        From 12 Oct. 2018, To 31 Mar. 2021, Project Closed
        Sipa1;MSCs;tumor microenvironment;cancer immunity;scRNA sequencing;Aged;Bcr-Abl mutation;Colon caner
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18F18406/
      • Senescence associated T cells among healthy volunteer and patients with hematological cancer.
        Grant-in-Aid for Scientific Research (C)
        Fukushima Medical University
        YUHKO SUZUKI
        From 01 Apr. 2013, To 31 Mar. 2017, Project Closed
        免疫老化;T細胞;健常人;CML;CLL;MDS;年齢;Eomesdermin;PD-1;ヘルパーT細胞;人;慢性骨髄性白血病;急性骨髄性白血病
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461455/
      • Altered function and structure of immune system in ageing and diseases
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        Kyoto University
        Nagahiro Minato
        From 28 Jun. 2012, To 31 Mar. 2017, Project Closed
        T細胞;細胞老化;免疫老化;恒常性増殖;老化関連疾患;自己免疫病;慢性炎症;Ｔ細胞老化;濾胞Ｔ細胞;全身性エリテマトーデス;糖尿病;加齢関連疾患
        https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-24111008/
      • Analysis and Synthesis of Multidimensional Immune Organ Network
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Biological Sciences
        The University of Tokushima
        Yousuke TAKAHAMA
        From 28 Jun. 2012, To 31 Mar. 2017, Project Closed
        免疫学;ストローマ細胞;免疫の場;リンパ器官;免疫空間
        https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-24111001/
      • Research for a mechanism of prostate cancer metastasis through a SPA-1(Rap1GAP) signaling pathway.
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Kouji YOSHIMURA
        From 01 Apr. 2008, To 31 Mar. 2011, Project Closed
        前立腺癌;Rap1;Spa-1;転移;癌転移;small G protein;SPA-1;RAP1;ECM
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591855/
      • Immunological Self Recognition and its Disorders
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        From 01 Apr. 2007, To 31 Mar. 2012
        https://kaken.nii.ac.jp/grant/KAKENHI-AREA-527/
      • smallGproteinを介した新たな癌転移機構の解明
        Grant-in-Aid for Exploratory Research
        Kyoto University
        中村 英二郎
        From 01 Apr. 2007, To 31 Mar. 2008, Project Closed
        small G protein;前立腺癌;癌転移;SPA-1
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19659077/
      • MicroRNA profiling of human lupus nephritis and murine lupus-like nephritis.
        Grant-in-Aid for Scientific Research (C)
        Kobe University
        Seiji KAWANO
        From 01 Apr. 2007, To 31 Mar. 2009, Project Closed
        膠原病学;ループス腎炎;PD-1;トレランス;マイクロRNA;NZB;W F1;ループス賢炎
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591167/
      • Immunological Self Recognition and its Disorders
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University
        Nagahiro MINATO
        From 01 Apr. 2007, To 31 Mar. 2012, Project Closed
        自己認識;免疫制御;胸腺;自己免疫病;炎症;がん;免疫系自己;自己識別;免疫病態;自己寛容;免疫組織;がん免疫;獲得免疫;免疫老化;白血病;T細胞;アナジー;G蛋白;自己免疫
        https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-19059009/
      • Immune Response to Malignant Cells and its Regulation
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University
        Nagahiro MINATO
        From 01 Apr. 2007, To 31 Mar. 2012, Project Closed
        自己認識;免疫制御;胸腺;自己免疫病;炎症;がん;免疫老化;白血病;全身性自己免疫病;T細胞;がん免疫;アナジー;G蛋白
        https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-19059008/
      • 生体防御と免疫病制御の統合的パラダイム
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        湊 長博
        From 01 Apr. 2006, To 31 Mar. 2007, Project Closed
        生体防御;免疫病;免疫応答;生体恒常性
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18639002/
      • PROPAGATION OF A UNIQUE V^σ1-BEARING V^σT CELLS CLONE WITHIN GRAFT INFILTRATES OF HUMAN LIVER TRANSPLANTATION TOLERANCE-IMMUNOPRIVILEGED LIVER SPECIFIC ?-
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Takaaki KOSHIBA
        From 01 Apr. 2005, To 31 Mar. 2007, Project Closed
        免疫寛容;肝移植;免疫制御;移植;ヒト;γ6細胞, liver;tolerance
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17591329/
      • Regulation and Control of Immune Surveillance
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University
        Nagahiro MINATO
        From 01 Apr. 2003, To 31 Mar. 2007, Project Closed
        免疫監視;がん免疫;白血病;免疫抑制;SPA-1;免疫療法;T細胞応答;メモリーT細胞;G蛋白;T細胞;Rap1;自己免疫病;自己抗体;造血幹細胞;ループス腎炎;レセプター編集;遺伝子ノックアウトマウス;骨髄幹細胞異常症;免疫不全;抗DNA抗体;アナジー;低分子G蛋白;癌抑制遺伝子;免疫記憶, Immune surveillance;Tumor immunity;Leukemia;Immune suppression;SPA-1;Tumor immunotherapy;T cell responsiveness;Memory T cells
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15078204/
      • Immune Surveillance, Its cellular and molecular basis, regulation and maintenance
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        RIKEN;Kyushu University
        Takeshi WATANABE
        From 01 Apr. 2003, To 31 Mar. 2007, Project Closed
        免疫監視;時空間的制御;胸腺、骨髄・二次リンパ節;抗原認識、多様性;免疫記憶;シグナル伝達;自己免疫病;再生、修復;胸腺、骨髄、リンパ組織;危険シグナル;免疫監視機構;自然免疫;認識の多様性;免疫シグナル;ワクチン;免疫組織の修復と強化;免疫監視システム;免疫系の修復と強化;免疫制御;がん;感染症;アレルギー, immune surveillance;spatio-temporal regulation;thymus, bone marrow, lymph nodes;recognition and diversity;memory;signal transduction;autoimmune diseases;regeneration,
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15078101/
      • Mechanism for autoimmune dilated cardiomyopathy in PD-1-deficient mice
        Grant-in-Aid for Scientific Research (B)
        KYOTO UNIVERSITY
        Nagahiro MINATO
        From 01 Apr. 2001, To 31 Mar. 2003, Project Closed
        PD-1;PD-L1;抑制性レセプター;自己免疫疾患;自己抗体;自己抗原;拡張型心筋症, PD-1;PD-L1;Negative receptors;Autojmmune diseases;Autoantibody;Antoantigen;Dilated cardiomyopathy
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13470071/
      • 獲得性生体情報の構築・応答ならびにその異常と病態の研究
        Grant-in-Aid for COE Research
        Kyoto University
        本庶 佑
        From 01 Apr. 2000, To 31 Mar. 2005, Project Closed
        クラススイッチ;体細胞突然変異;AID;PD-1;PD-L;IMCT法;LDL受容体;グルタミン酸受容体;SPA-1;パーキンソン;立体構造
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12CE2006/
      • Regulation of T-cell and antigen-presenting cell interactions by Rapl.
        Grant-in-Aid for Scientific Research (C)
        KYOTO UNIVERSITY
        Masakazu HATTORI
        From 01 Apr. 2000, To 31 Mar. 2002, Project Closed
        Rap1;SPA-1;T細胞;アナジー;アポトーシス;p27kip1;アポプトーシス;P27kip1;FAS;Rap1GAP;APC;LFA-1;ICAM-1;Spa-1, Rap1;SPA- 1;T cell;anergy;apoptosis;p27kip1
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670300/
      • Pattern recognition by human γδ T cells and innate immunity.
        Grant-in-Aid for Scientific Research (C)
        KYOTO UNIVERSITY
        Yoshimasa TANAKA
        From 01 Apr. 2000, To 31 Mar. 2002, Project Closed
        免疫系;γδ型T細胞;非ペプチド性抗原;T細胞受容体;病原性細菌;自然免疫;獲得性免疫;がん細胞;ピロリン酸モノエステル;アルキルアミン;結核菌;病原性大腸菌;パターン抗原;非ペプチド抗原;パターン認識, immune system;γδ T cell;nonpeptide antigen;T cell receptor;pathogenic microbe;innate immunity;acquired_immunity;tumor cell
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670299/
      • ヒトγδ型T細胞を用いた特異的癌免疫療法の開発
        Grant-in-Aid for Scientific Research on Priority Areas (C)
        Biological Sciences
        Kyoto University
        田中 義正
        From 01 Apr. 2000, To 31 Mar. 2001, Project Closed
        γδ型T細胞;ピロリン酸モノエステル;非ペプチド抗原;パターシ認識;自然免疫
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12217068/
      • T細胞の抗原認識と活性化制御
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Chiba University
        斉藤 隆
        From 01 Apr. 2000, To 31 Mar. 2003, Project Closed
        部分アゴニストペプチド;T細胞エピトープ;免疫シナプス形成;制御性アダプター分子;インテグリン活性化;慢性骨髄性白血;Th2分化;ポリコーム遺伝子;免疫シナプス;raft;アゴニストペプチド;ヒストンアセチル化;Th1・Th2;rap-1;インテグリン;SPA-1;Gab-2;CTLA-4;Rap-1;Spa-1;Th1;Th2;カルシニューリン;シグナルクロストーク;部分アゴニスト
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12051203/
      • 低分子G蛋白シグナル系を介した骨髄微小環境形成の分子機構の解析
        Grant-in-Aid for Scientific Research on Priority Areas (A)
        Biological Sciences
        Kyoto University
        服部 雅一
        From 01 Apr. 2000, To 31 Mar. 2001, Project Closed
        Rap1;Spa-1;AF6;Eph;骨髄微小環境;ノックアウトマウス
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12036210/
      • Identification of a ubiquitin-ligase which recognizes oxidized proteins.
        Grant-in-Aid for Scientific Research (C)
        KYOTO UNIVERSITY
        Kazuhiro IWAI
        From 01 Apr. 1999, To 31 Mar. 2001, Project Closed
        酸化変化;ユビキチン修飾;鉄イオン代謝;IRP2;プロテアソーム;選択的蛋白分解, Oxidative modificatin;ubiquitination;iron metabolism;IRP2;proteasome;selective proteolysis
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11680630/
      • 造血系生成過程における低分子G蛋白シグナル系の関与
        Grant-in-Aid for Scientific Research on Priority Areas (A)
        Biological Sciences
        Kyoto University
        服部 雅一
        From 01 Apr. 1999, To 31 Mar. 2000, Project Closed
        Rapl;SPA-1;ノックアウトマウス;インテグリン;アナジー
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11162214/
      • 酸化的修飾がシグナルとなるユビキチン依存性蛋白分解の細胞機能制御における役割
        Grant-in-Aid for Scientific Research on Priority Areas (A)
        Kyoto University
        岩井 一宏
        From 01 Apr. 1999, To 31 Mar. 2000, Project Closed
        酸化変化;ユビキチン修飾;鉄イオン代謝;プロテアソーム;選択的蛋白分解
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11144220/
      • レパートリー形成の分子機構
        Grant-in-Aid for Scientific Research on Priority Areas (A)
        Kyoto University
        湊 長博
        From 01 Apr. 1999, To 31 Mar. 2000, Project Closed
        抗原レセプター;レパートリー形成;低分子量G蛋白;インテグリン;胚中心;細胞分化;転写因子;遺伝子組み換え;低分子G蛋白;Rap1;Ras;シグナル伝達;細胞接着;細胞骨格;免疫応答;アナ-ジ-;クローン増巾;GTPase活性化蛋白;コミットメント;Tリンパ球;Bリンパ球;胸腺外分化
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08282103/
      • Essential role of transcriptional regulator Hesl in the early development of T cells.
        Grant-in-Aid for Scientific Research (C)
        KYOTO UNIVERSITY
        Masakazu HATTORI
        From 01 Apr. 1998, To 31 Mar. 2000, Project Closed
        Hes1;bHLH;T;RAG2;Notch;胸腺;HES1;T細胞増殖制御;ストローマ細胞;Pre T細胞;T細胞初期分化;double negative;TCR非依存性増殖, Hesl;bHLH;T cell;RAG2;Notchl;thymus
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670300/
      • 低分子G蛋白シグナル系を介した造血系細胞分化制御機構
        Grant-in-Aid for Scientific Research on Priority Areas (A)
        Biological Sciences
        Kyoto University
        服部 雅一
        From 01 Apr. 1998, To 31 Mar. 1999, Project Closed
        SPA-1;Rap1;cell adhesion;C3G;32D;integrin
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10181211/
      • 酸化的修飾がシグナルとなるユビキチン依存性蛋白分解の細胞機能制御における役割
        Grant-in-Aid for Scientific Research on Priority Areas (A)
        Kyoto University
        岩井 一宏
        From 01 Apr. 1998, To 31 Mar. 1999, Project Closed
        酸化変化;ユビキチン修飾;鉄イオン代謝;プロテアソーム;選択的蛋白分解
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10163220/
      • Molecular mechanisms of lymphocyte proliferation during the development
        Grant-in-Aid for Scientific Research (B)
        KYOTO UNIVERSITY
        Nagahiro MINATO
        From 01 Apr. 1997, To 31 Mar. 1999, Project Closed
        低分子G蛋白;Rap1;Ras;細胞骨格;シグナル伝達;抗原レセプター;免疫応答;GTPase活性化蛋白(GAP);アナ-ジ-;バキュロウイルス;低分子量G蛋白;クローン増巾;GTPase活性化蛋白, Small GTPases;Rap 1;Ras;Cytaskleton;Signal transduction;Antigen receptors;Immune response;GTPase activating protain(GAP)
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09470093/
      • 酸化的修飾がシグナルとなるユビキチン依存性蛋白分解の細胞機能制御における役割
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        岩井 一宏
        From 01 Apr. 1997, To 31 Mar. 1998, Project Closed
        酸化的修飾;ユビキチン修飾;鉄イオン代謝;プロテアソーム;選択的蛋白分解
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09267218/
      • Molecular Mechanisms and Intervention of Immunological Diseases.
        Grant-in-Aid for Scientific Research on Priority Areas
        The University of Tokyo
        Kiyoshi TAKATSU
        From 01 Apr. 1996, To 31 Mar. 2001, Project Closed
        免疫異常;レパートリー形成;免疫識別の多型性;免疫識別の多様性;情報伝達;リンパ球の機能分化;免疫病とその修復;新しい診断法;免疫職別の多型性;免疫職別の多様性;免疫制御;免疫寛容;MHCと抗原ペプチド;シグナル伝達;抗原レセプター;サイトカイン;自己免疫病;アレルギー;免疫病の分子機構;自己認識;免疫病;免疫不全;自己免疫疾患, Repertoire selection;Antigen receptor;Immunodiversity;Tyrosine kinase;Inflammation;Immunological disorders;Signal transduction;IL-5
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08282101/
      • 核内GTPase活性化蛋白の機能制御に関与する細胞内蛋白質限定分解機構の解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        服部 雅一
        From 01 Apr. 1996, To 31 Mar. 1997, Project Closed
        Spa‐1;RaplGAP;PEST;プロセッシング;ATP依存性プロテアーゼ
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08278214/
      • Comparative study of immunological tolerance in the liver transplantation from cadaver and living donor
        Grant-in-Aid for international Scientific Research
        KYOTO UNIVERSITY
        Yoshio YAMAOKA
        From 01 Apr. 1996, To 31 Mar. 1997, Project Closed
        免疫寛容誘導;マイクロキメリズム;ドナー特異的遺伝子;MHC-class I;NK細胞;KIR, immunotolerance;micro-chmerism;donor-specific gene;MHC-class 1;NK cell;KIR
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08044278/
      • Cell cycle regulation of a lympho-hematopoietic specific Rap1GTPase-activating protein, Spa-1 in lymphocyres.
        Grant-in-Aid for Scientific Research (C)
        KYOTO UNIVERSITY
        Masakazu HATTORI
        From 01 Apr. 1995, To 31 Mar. 1997, Project Closed
        Spa-1;Rapl;GAP;細胞周期;11g13.3;Rap1;11q13.3;リンパ球活性化;低分子G蛋白;核内蛋白;プロセッシング;GTPase活性化蛋白;ロイシンジッパー;がん抑制遺伝子, Spa-1;Rap1;GAP;cell cycle progression;11q13.3
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07670367/
      • Molecular mechanisms for cell cycle control in the immune system
        Grant-in-Aid for Scientific Research (B)
        KYOTO UNIVERSITY
        Nagahiro MINATO
        From 01 Apr. 1995, To 31 Mar. 1997, Project Closed
        リンパ球;低分子量G蛋白;Rap1;GTPase活性化蛋白;細胞周期;バキュロウイルス;細胞増殖;染色体マッピング;低分子G蛋白;G蛋白活性化蛋白;がん遺伝子;がん抑制遺伝子;シグナル伝達;サイトカイン;リンパ球活性化;細胞分裂;細胞同期;核内蛋白;ロイシンジッパー, lymphocutes;small G protein;Rap1;GTPase activating protein;cell cycle;baculovirus;proliferation;chusmosomal mapping
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457084/
      • 免疫病の分子機構とその修復
        Grant-in-Aid for Co-operative Research (B)
        The University of Tokyo
        高津 聖志
        From 01 Apr. 1995, To 31 Mar. 1996, Project Closed
        免疫病;レパートリー形成;免疫識別;情報伝達;機能分化
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07357013/
      • MHC非拘束性T細胞の抗原レセプターと認識抗原の研究
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        湊 長博
        From 01 Apr. 1995, To 31 Mar. 1996, Project Closed
        T細胞レセプター;主要組織適合抗原;個体発生;T細部亜群
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07257212/
      • 細胞周期調節機構における核内GTPase活性化蛋白の機能
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        服部 雅一
        From 01 Apr. 1995, To 31 Mar. 1996, Project Closed
        核内GTPase活性化蛋白;低分子G蛋白;細胞周期;プロセッシング;ロイシンジッパー;PEST配列;第19染色体;ガン抑制遺伝子
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07254207/
      • Nuclear small G protein system involved in cell cycle.
        Grant-in-Aid for international Scientific Research
        KYOTO UNIVERSITY
        Nagahiro MINATO
        From 01 Apr. 1995, To 31 Mar. 1996, Project Closed
        核内蛋白;GTPase活性化蛋白;プロセッシング;低分子G蛋白;ロイシンジッパー;PEST配列;がん抑制遺伝子;第19染色体, Ran binding;nuclear protein;processing;cell cycle progression;Ran;RCC-1 system;PEST;leucine zipper motif
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07044250/
      • 造血組織に局在する新しいT細胞亜群の認識レパートリーの研究
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        湊 長博
        From 01 Apr. 1994, To 31 Mar. 1995, Project Closed
        T細胞抗原レセプター;胎児性抗原;胎生癌細胞;4F2抗原;髄外造血;胎生造血
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06265217/
      • 核に局在するsmallG蛋白系による細胞増殖調節機構の解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        服部 雅一
        From 01 Apr. 1994, To 31 Mar. 1995, Project Closed
        Ran GAP;核内蛋白;有糸分裂破綻;細胞周期進行阻害
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06262213/
      • Analysis of a lympho-hematopoietic specific nuclear protein with homology to RaplGAP
        Grant-in-Aid for General Scientific Research (C)
        KYOTO UNIVERSITY
        Masakazu HATTORI
        From 01 Apr. 1993, To 31 Mar. 1995, Project Closed
        RanGAP;RaplGAP;核内蛋白;細胞周期進行;インターロイキン2;differential hybridization;Ran;RCC-1系;Ran GAP;有糸分裂破綻;リン酸化会合分子;細胞周期;Rap1GAPホモログ;翻訳時ホッピング;GAP活性;細胞増殖抑制, RanGAP;RaplGAP;nuclear protein;cell cycle progression;Ran;RCC-1 system;Interleukin-2;differntial hybridization
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05670300/
      • Analysis of Ligands Involved in the T-cell Receptor Repartoire Formation of T-cells Lecalized in Hematopoiatic Tissues.
        Grant-in-Aid for General Scientific Research (B)
        KYOTO UNIVERSITY
        Nagahiro MINATO
        From 01 Apr. 1993, To 31 Mar. 1995, Project Closed
        T細胞抗原レセプター;主要組織適合抗原;4F2抗原;個体発生;胎生期抗原;髄外造血;胎生癌細胞;ヌードマウス;胎児性抗原;T細胞レパトア;造血前駆細胞;骨髄;胎生造血;インターロイキン3;胎児抗原;造血系前駆細胞, T-cell Receptor;Major thstocompatibility Antigens;4F2 antigen;Ontogeny;Fetal antigens;Extramedullary Hematopoiesis;Embryonal Carcinomas;Nude Mice
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05454206/
      • 骨髄局在T細胞の認識レパートリー形成に関わる新しい拘束因子とその制御
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        湊 長博
        From 01 Apr. 1993, To 31 Mar. 1994, Project Closed
        T細胞抗原レセプター;4F2抗原;胎生期抗原;MHC抗原;造血系幹細胞
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05272214/
      • 腫瘍細胞破壊のキラーメカニズム
        Grant-in-Aid for Cancer Research
        Tohoku University
        橋本 嘉幸
        From 01 Apr. 1992, To 31 Mar. 1993, Project Closed
        腫瘍細胞破壊機構;キラー細胞;T細胞受容体;抗原ペプチド;接着分子;マクロファージレクチン;パーフォリン;共集点レーザー顕微鏡
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04151008/
      • 腫瘍細胞破壊のキラ-メカニズム
        Grant-in-Aid for Cancer Research
        Tohoku University
        橋本 嘉幸
        From 01 Apr. 1991, To 31 Mar. 1992, Project Closed
        キラ-細胞;マクロファ-ジ;キラ-T細胞;T細胞受容体;LAK細胞;パ-フォリン;接着分子;共焦点レザ-顕微鏡
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03151008/
      • Studies on the Signal Transduction in T Lymphocytes via Antigen and Lymphokine Receptors.
        Grant-in-Aid for General Scientific Research (B)
        Jichi Medical School
        Nagahiro MINATO
        From 01 Apr. 1990, To 31 Mar. 1992, Project Closed
        インタ-ロイキン2;インタ-ロイキン2レセプタ-;トランスジェニックマウス;CD45;フォスファチジル・イノシト-ル;シグナル伝達;DNA結合蛋白;リンフォカイン;抗原レセプタ-;ハイブリド-マ;インタ-ロイキン3;T細胞レセプタ-;アポプト-シス;フォスファチジルイノシト-ル結合蛋白;遺伝子再構成;細胞分化, Interleukin 2;IL 2 receptor;Transgenic mice;CD45;Phosphatidylinositol;Signal transduction;DNA-binding protein
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02454194/
      • 腫瘍細胞破壊のキラ-メカニズム
        Grant-in-Aid for Cancer Research
        Tohoku University
        橋本 嘉幸
        From 01 Apr. 1990, To 31 Mar. 1991, Project Closed
        キラ-細胞;標的細胞破壊;マクロファ-ジ;NK細胞;LAK細胞;キラ-因子;接着分子;バクスペンフィック抗体
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02151009/
      • リンパ球の増殖・分化の制御及びその白血病化についての分子生物学的研究
        Grant-in-Aid for Cancer Research
        Kyushu University
        渡邊 武
        From 01 Apr. 1989, To 31 Mar. 1990, Project Closed
        IL2受容体;IL5受容体;シグナル伝達;T細胞抗原レセプター遺伝子;オートクリン機構;ストロマ細胞;遺伝子発現調節;リンパ球の分化
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01010045/
      • 自然抵抗性抗がんエフェクター系の作用機作と、その活性化による制がん効果
        Grant-in-Aid for Cancer Research
        Kyoto University
        村松 繁
        From 01 Apr. 1989, To 31 Mar. 1990, Project Closed
        抗がん自然低抗性;食細胞;好中球;マクロファージ;ナチュラルキラー;インターフェロン;腫瘍壊死因子;胎仔肝
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01010033/
      • 腫瘍局所に対する至適な化学療法の確立に関する研究
        Grant-in-Aid for Cancer Research
        Kyushu University
        馬場 恒男
        From 01 Apr. 1988, To 31 Mar. 1989, Project Closed
        改良癌化学療法;2経路化学療法;アンギオテンシン昇圧;癌性腹膜炎;動注療法;肝癌、血管透過性;薬理動態;キニン濃度
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63010050/
      • リンパ球の増殖・分化の制御およびその白血病化について分子生物学的研究
        Grant-in-Aid for Cancer Research
        Kyushu University
        渡辺 武
        From 01 Apr. 1988, To 31 Mar. 1989, Project Closed
        リンホカイン;リンホカイン・レセプター;IL-2;IL-3;IL-5;NK細胞;骨髄幹細胞;ストロマ細胞;遺伝子発現制御;白血病;リンパ球の白血病化
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63010049/
      • 自然抵抗性抗がんエフェクター系の作用機作とその活性化による制がん効果
        Grant-in-Aid for Cancer Research
        Kyoto University
        村松 繁
        From 01 Apr. 1988, To 31 Mar. 1989, Project Closed
        抗がん自然抵抗性;食細胞;好中球;マクロファージ;ナチュラルキラー;マイコプラズマ;インターロイキン;動物レクチン
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-63010039/
      • Recognition and Early Differentiation of Natural Killer Cells
        Grant-in-Aid for General Scientific Research (B)
        Jichi Mediacl School
        Nagahiro MINATO
        From 01 Apr. 1987, To 31 Mar. 1989, Project Closed
        マウス白血病ウイルス;顆粒リンパ球;T細胞レセプター遺伝子;インターロイキン3;造血系幹細胞;インターロイキン2;NK活性;T細 胞レセプター;大顆粒リンパ球(LGL);ナチュラルキラー(NK);多能性幹細胞, Murine Leukemia Virus;Large Granular Lymphocytes;T-cell Recepter Genes;Interleukin 2
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62480168/
      • HTLV・I抗体陽性者の長期遺跡
        Grant-in-Aid for Cancer Research
        Kumamoto University
        高月 清
        From 01 Apr. 1987, To 31 Mar. 1988, Project Closed
        ATL;HTLVーI;免疫不全;発がん;糞線虫症
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62010058/
      • リンパ球の増殖,分化の制御およびその白血病化についての分子生物学的研究
        Grant-in-Aid for Cancer Research
        Kyushu University
        渡辺 武
        From 01 Apr. 1987, To 31 Mar. 1988, Project Closed
        リンホカイン;リンホカイン・レセプター;ILー2;ILー3;ILー5,NK細胞;ストロマ細胞;遺伝子発現
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62010056/
      • 自然抵抗性抗がんエフェクター系の作用機作と,その活性化による制がん効果
        Grant-in-Aid for Cancer Research
        Kyoto University
        村松 繁
        From 01 Apr. 1987, To 31 Mar. 1988, Project Closed
        抗がん自然抵抗性;食細胞;好中球;マクロファージ;ナチュラルキラー;インターフェロン;インターリウキン;腫瘍壊死因子
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62010040/
      • NK細胞の特異臓器分布と腫瘍細胞との相互作用における基底膜蛋白ラミニンの役割
        Grant-in-Aid for Cancer Research
        Jichi Medical University
        湊 長博
        From 01 Apr. 1986, To 31 Mar. 1987, Project Closed
        NK細胞;血管内皮細胞;基底膜蛋白;ラミニン;養子免疫療法;インターフェロン
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61015092/
      • リンフォカインとそのアクセプターに関する免疫学的及び分子生物学的研究
        Grant-in-Aid for Cancer Research
        Osaka University
        岸本 忠三
        From 01 Apr. 1986, To 31 Mar. 1987, Project Closed
        BSF2;BCGF【II】;TRF;Bリンパ球増殖因子;IL-2;IL-2レセプター;HTLV-1(PX);NK細胞;プレB細胞株;抗体遺伝子
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-61010049/
      • Studies on the Functions, Growth Regulation, and Genetic Phenotypes of Cloned NK Cells.
        Grant-in-Aid for General Scientific Research (C)
        Jichi Medical School
        Nagahiro MINATO
        From 01 Apr. 1985, To 31 Mar. 1987, Project Closed
        クローン化NK細胞;T細胞レセプター遺伝子;インターロイキン2;インターロイキン2レセプター, Cloned NK cells;T cell receptor genes;interleukin 2
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60570226/
      • Immunological Self Recognition and its Disorders
        Grant-in-Aid for Scientific Research on Priority Areas
        Kyoto University
        From 01 Apr. 2007, To 31 Mar. 2012
        https://kaken.nii.ac.jp/grant/KAKENHI-AREA-527/

      External funds: others

      • Research on immunological diseases
        京大アステラス創薬融合拠点
        From 2007
        成宮　周
      • 文部科学省 橋渡し研究加速ネットワークプログラム
        From 2011, To 2015
        湊　長博
      • 厚生労働省 革新的医薬品・医療機器・再生医療製品実用化促進事業
        From 2012, To 2016
        湊　長博
      • 京都府 地域医療支援センター京都大学ブランチ事業
        From 2012, To 2013
        湊　長博
      • 医薬品分野（アルツハイマー病、非臨床評価、薬剤疫学） （平成26年度分）
        厚生労働省 革新的医薬品・医療機器・再生医療等製品実用化促進事業
        From 01 Apr. 2014, To 31 Mar. 2015
        湊　長博
      • 京都府 地域医療支援センター京都大学ブランチ事業
        From 01 Apr. 2014, To 31 Mar. 2015
        湊　長博
      • Cancer Immunotherapy using gdT cells
        文科省橋渡し研究支援推進プログラム
        From 2009, To 2013
        代表
      list
        Last Updated :2025/05/27

        Education

        Teaching subject(s)

        • From 01 Apr. 2024, To 31 Mar. 2025
          Frontiers of Biology
          N477, Spring, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Frontiers of Biology
          N477, Spring, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Frontiers of Biology
          N477, Spring, Institute for Liberal Arts and Sciences, 2
        • From Apr. 2011, To Mar. 2012
          免疫学
          Spring, 医学研究科
        • From Apr. 2012, To Mar. 2013
          Immunology
          Spring, 医学研究科
        • From Apr. 2013, To Mar. 2014
          Immunology
          Spring, 医学部
        • From Apr. 2013, To Mar. 2014
          Immunology
          Spring, 医学研究科
        • From Apr. 2013, To Mar. 2014
          Hands-on medical research experience
          Spring, 全学共通科目
        • From Apr. 2014, To Mar. 2015
          Immunology
          Spring, 医学部
        • From Apr. 2014, To Mar. 2015
          Immunology
          Spring, 医学研究科
        • From Apr. 2014, To Mar. 2015
          Hands-on medical research experience
          Spring, 全学共通科目
        • From Apr. 2015, To Mar. 2016
          Immunology
          Spring, 医学部
        • From Apr. 2015, To Mar. 2016
          Immunology
          Spring, 医学研究科
        • From Apr. 2016, To Mar. 2017
          Immunology
          Spring, 医学部
        • From Apr. 2021, To Mar. 2022
          Frontiers of Biology
          Spring, 全学共通科目

        Part-time lecturer

        • From 06 Apr. 2009, To 24 Mar. 2010
          徳島大学
        • From 09 Apr. 2007, To 31 Mar. 2008
          秋田大学, 医学部
        • From 01 Apr. 2005, To 30 Sep. 2005
          神戸大学, 大学院医学系研究科
        • From 01 Apr. 2004, To 30 Sep. 2004
          神戸大学, 大学院医学系研究科
        • From 01 Apr. 2001, To 30 Sep. 2001
          神戸大学, 医学部
        list
          Last Updated :2025/05/27

          Administration

          School management (title, position)

          • From 01 Apr. 2008, To 30 Sep. 2008
            企画委員会 委員
          • From 01 Oct. 2010, To 31 Mar. 2011
            人事審査委員会 委員
          • From 01 Oct. 2010, To 31 Mar. 2011
            企画委員会 委員
          • From 01 Oct. 2010, To 31 Mar. 2011
            保健衛生委員会 委員長
          • From 01 Oct. 2010, To 31 Mar. 2011
            吉田キャンパス整備専門委員会委員会 委員
          • From 01 Oct. 2010, To 31 Mar. 2011
            施設整備委員会 委員
          • From 01 Oct. 2010, To 31 Mar. 2011
            町家キャンパスプロジェクト専門委員会 委員
          • From 01 Oct. 2010, To 31 Mar. 2011
            全学共通教育委員会 委員
          • 企画委員その他多数
          • 京大アステラス融合拠点研究推進委員（副執行責任者）
          • From 01 Oct. 2010, To 30 Sep. 2012
            総長選考会議 委員
          • From 01 Oct. 2010, To 30 Sep. 2012
            人事審査委員会 委員
          • From 01 Apr. 2011, To 31 Mar. 2013
            京都大学情報環境整備委員会 委員
          • From 01 Apr. 2011, To 31 Mar. 2013
            京都大学施設整備委員会 委員
          • From 01 Apr. 2011, To 31 Mar. 2013
            全学共通教育委員会 委員
          • From 01 Apr. 2011, To 31 Mar. 2013
            戦略定員検討委員会 委員
          • From 01 Apr. 2011, To 31 Mar. 2013
            環境安全保健委員会 委員
          • From 01 Apr. 2011, To 31 Mar. 2013
            産官学連携本部運営協議会
          • From 01 Apr. 2002, To 31 Mar. 2004
            評議員
          • From 01 Apr. 2011, To 31 Mar. 2013
            高等教育研究開発推進機構執行協議会
          • From 01 Jul. 2011, To 30 Sep. 2012
            基金運営委員会 委員
          • From 01 Feb. 2012, To 30 Sep. 2012
            博士課程教育リーディングプログラム実施準備委員会 委員
          • From 01 Apr. 2012, To 31 Mar. 2013
            京都大学全学共通教育実施体制等特別委員会 委員
          • From 01 Apr. 2012, To 31 Mar. 2014
            利益相反審査委員会 委員
          • From 01 Apr. 2013, To 31 Mar. 2015
            環境安全保健委員会 委員
          • From 01 Oct. 2012, To 30 Sep. 2014
            企画委員会 委員
          • From 01 Oct. 2012, To 30 Sep. 2014
            基金運営委員会 委員
          • From 01 Oct. 2012, To 30 Sep. 2013
            教育研究組織改革専門委員会（第6部会） 副委員長
          • From 01 Apr. 2013, To 31 Mar. 2015
            研究科長部会議
          • From 01 Apr. 2013, To 30 Sep. 2013
            産官学連携本部運営協議会
          • From 01 Apr. 2013, To 31 Mar. 2015
            情報環境整備委員会 委員
          • From 01 Oct. 2010, To 30 Sep. 2014
            全学情報セキュリティ委員会 委員
          • From 01 Oct. 2010, To 30 Sep. 2014
            大学評価委員会 委員
          • From 01 Oct. 2010, To 30 Sep. 2014
            教育研究評議会 評議員
          • From 01 Oct. 2010, To 30 Sep. 2014
            部局長会議
          • From 01 Apr. 2012, To 30 Sep. 2013
            利益相反審査委員会 委員
          • From 01 Apr. 2013, To 30 Sep. 2014
            京都大学情報環境整備委員会 委員
          • From 01 Apr. 2011, To 30 Sep. 2014
            企画委員会 委員
          • From 01 Oct. 2010, To 30 Sep. 2014
            医学研究科 研究科長
          • From 01 Oct. 2010, To 30 Sep. 2014
            医学部 学部長
          • From 11 Sep. 2012, To 30 Sep. 2014
            博士課程教育リーディングプログラム運営会議 委員
          • From 01 Oct. 2010, To 30 Sep. 2014
            原子力研究整備委員会 委員
          • From 01 Apr. 2014, To 30 Sep. 2014
            吉田寮整備委員会委員
          • From 05 Feb. 2014, To 31 Mar. 2015
            吉田寮業務実施委員会 委員
          • From 01 Apr. 2013, To 30 Sep. 2014
            国際高等教育院教養・共通教育協議会 委員
          • From 01 Oct. 2014
            教育研究評議会 評議員
          • From 01 Apr. 2013, To 30 Sep. 2014
            産官学連携本部運営協議会協議員 委員
          • From 01 Oct. 2010, To 30 Sep. 2014
            研究科長部会
          • From 01 Apr. 2011, To 31 Mar. 2012
            総合技術部委員会 委員
          • From 01 Apr. 2012, To 30 Sep. 2012
            総合技術部委員会 委員
          • From 02 Jul. 2012, To 30 Sep. 2014
            教育研究組織改革専門委員会 副委員長
          • From 01 Oct. 2012, To 31 Mar. 2013
            総合技術部委員会 委員
          • From 01 Apr. 2013, To 30 Sep. 2013
            総合技術部委員会 委員
          • From 01 Jul. 2013, To 10 Sep. 2013
            京都大学産学共同実用化促進事業実施準備委員会 委員
          • From 01 Oct. 2013, To 31 Mar. 2014
            総合技術部委員会 委員
          • From 01 Apr. 2014, To 30 Sep. 2014
            総合技術部委員会 委員
          • From 01 Aug. 2014, To 30 Sep. 2014
            京都大学研究公正の推進検討委員会 委員
          • From 01 Oct. 2014, To 30 Sep. 2018
            理事
          • From 01 Oct. 2014, To 30 Sep. 2016
            京都大学産学共同実用化促進事業実施委員会 ２号委員
          • From 01 Oct. 2014, To 30 Sep. 2016
            全学共用スペース有効活用専門委員会 2号委員
          • From 01 Oct. 2014, To 30 Sep. 2016
            国際戦略委員会 委員
          • From 01 Oct. 2014, To 30 Sep. 2016
            企画委員会 委員長
          • From 01 Oct. 2014, To 30 Sep. 2016
            京都大学安全保障輸出管理委員会 委員長
          • From 01 Oct. 2014, To 28 Feb. 2015
            京都大学研究公正の推進検討委員会 委員長
          • From 01 Oct. 2014, To 31 Mar. 2016
            京都大学国際交流推進機構協議会 協議員
          • From 01 Oct. 2014, To 30 Sep. 2016
            京都大学国際交流推進機構協議会 協議員
          • From 01 Oct. 2014, To 31 Mar. 2016
            京都大学国際交流推進機構協議会幹事会 協議員
          • From 01 Oct. 2014, To 31 Mar. 2016
            学域・学系制度検討ワーキンググループ 座長
          • From 01 Oct. 2014, To 30 Sep. 2016
            吉田キャンパスマスタープラン専門部会 部会員
          • From 01 Oct. 2014, To 31 Mar. 2015
            危機管理委員会 委員
          • From 01 Oct. 2014, To 30 Sep. 2016
            京都大学産学共同実用化促進事業共同研究推進グループ 委員
          • From 01 Oct. 2014
            経営協議会
          • From 01 Oct. 2014, To 30 Sep. 2016
            研究科長部会
          • From 01 Oct. 2014, To 30 Sep. 2016
            部局長会議
          • From 01 Oct. 2014, To 30 Sep. 2016
            役員会
          • From 01 Mar. 2015
            京都大学研究公正委員会 委員長
          • From 01 Apr. 2015, To 31 Mar. 2016
            危機管理委員会 委員
          • From 01 Jan. 2011, To 31 Mar. 2012
            教員活動評価委員会
          • From 01 Nov. 2012, To 31 Mar. 2013
            教員活動評価委員会
          • From 01 Oct. 2014, To 30 Sep. 2016
            総合技術部委員会
          • From 01 Oct. 2014, To 09 Sep. 2017
            京都大学産学共同実用化促進事業実施委員会 2号委員
          • From 01 Oct. 2014, To 30 Sep. 2016
            人事制度検討会 委員
          • From 01 Apr. 2015, To 31 Mar. 2017
            危機管理委員会 委員
          • From 01 Nov. 2015, To 31 Mar. 2016
            教員表彰選考委員会 委員
          • From 01 Apr. 2011, To 30 Sep. 2014
            総合技術部委員会 委員
          • From 01 Jan. 2011, To 31 Mar. 2012
            教員活動評価委員会 委員
          • From 01 Nov. 2012, To 31 Mar. 2013
            教員活動評価委員会 委員
          • From 01 Apr. 2016, To 30 Sep. 2016
            国際展開委員会 委員
          • From 01 Apr. 2016, To 30 Sep. 2016
            国際戦略本部運営協議会 協議員
          • From 01 Oct. 2014, To 03 Jun. 2016
            国際戦略委員会 委員
          • From 01 Apr. 2016
            研究倫理・安全推進委員会 委員長
          • From 01 Oct. 2014
            吉田キャンパスマスタープラン専門部会 部会委員
          • From 01 Oct. 2016, To 30 Sep. 2018
            企画委員会 委員長
          • From 12 Jul. 2016, To 31 Mar. 2017
            指定国立大学法人制度検討ワーキンググループ 座長
          • From 01 Oct. 2016, To 30 Sep. 2018
            国際展開委員会 委員
          • From 01 Oct. 2016, To 30 Sep. 2018
            国際戦略本部運営協議会 協議員
          • From 01 Oct. 2016, To 30 Sep. 2018
            京都大学安全保障輸出管理委員会 委員長
          • From 16 May 2017
            研究活動上の行動規範に関する検討ワーキンググループ 座長（委員長）
          • From 01 Oct. 2016, To 30 Sep. 2018
            役員会
          • From 01 Oct. 2016, To 30 Sep. 2018
            京都大学経営協議会
          • From 01 Oct. 2016, To 30 Sep. 2018
            教育研究評議会 評議員
          • From 01 Oct. 2016, To 30 Sep. 2018
            部局長会議
          • From 01 Oct. 2016, To 30 Sep. 2018
            研究科長部会
          • From 01 Apr. 2015, To 31 Mar. 2018
            危機管理委員会 委員
          • From 01 Oct. 2014, To 31 Mar. 2018
            人事制度検討会 委員
          • From 01 Apr. 2017, To 31 Mar. 2018
            全学共用スペース有効活用専門委員会 2号委員
          • From 01 Apr. 2017, To 31 Mar. 2018
            吉田キャンパスマスタープラン専門部会 部会委員
          • From 01 Oct. 2010, To 30 Sep. 2014
            医学研究科長
          • From 01 Oct. 2010, To 30 Sep. 2014
            医学部長
          • From 01 Oct. 2014
            副学長
          • From 01 Oct. 2014, To 09 Sep. 2019
            京都大学産学共同実用化促進事業実施委員会 委員
          • From 01 Oct. 2014, To 30 Sep. 2018
            人事制度検討会 委員
          • From 01 Apr. 2018
            研究公正委員会 委員
          • From 01 Mar. 2015, To 31 Mar. 2018
            研究公正委員会 委員長
          • From 16 May 2017, To 31 Mar. 2018
            研究活動上の行動規範に関する検討ワーキンググループ 座長（委員長）
          • From 0000
            全学共用スペース有効活用専門委員会 2号委員
          • From 01 Oct. 2014, To 0000
            吉田キャンパスマスタープラン専門部会 部会委員
          • From 01 Oct. 2014, To 30 Sep. 2020
            理事
          • From 01 Oct. 2018, To 30 Sep. 2020
            企画委員会 委員長
          • From 24 Jul. 2018, To 30 Sep. 2020
            企画委員会On-site Laboratory認定専門委員会 委員長
          • From 24 Jul. 2018, To 30 Sep. 2020
            企画委員会若手重点戦略定員専門委員会 委員長
          • From 01 Oct. 2018, To 30 Sep. 2020
            国際戦略本部運営協議会 協議員
          • From 01 Oct. 2018, To 30 Sep. 2020
            戦略調整会議 議長
          • From 01 Apr. 2019, To 30 Sep. 2020
            競争的資金等の不正防止計画推進室 統括管理責任者
          • From 01 Mar. 2015, To 30 Sep. 2020
            研究公正委員会 委員長
          • From 01 Oct. 2018, To 30 Sep. 2020
            京都大学安全保障輸出管理委員会 委員長
          • From 01 Oct. 2014
            京都大学産学共同実用化促進事業実施委員会 委員
          • From 01 Oct. 2014
            全学共用スペース有効活用専門委員会 委員
          • From 01 Oct. 2014
            吉田キャンパスマスタープラン専門部会 部会員
          • From 01 Oct. 2018, To 30 Sep. 2020
            役員会
          • From 01 Oct. 2018, To 30 Sep. 2020
            京都大学経営協議会
          • From 01 Oct. 2018, To 30 Sep. 2020
            教育研究評議会 評議員
          • From 01 Oct. 2018, To 30 Sep. 2020
            部局長会議
          • From 01 Oct. 2018, To 30 Sep. 2020
            研究科長部会
          • From 01 Oct. 2016
            京都大学危機管理委員会 委員
          • From 01 Oct. 2018, To 30 Sep. 2020
            人事制度検討会 委員
          • From 01 Apr. 2020, To 30 Sep. 2020
            京都大学研究者情報整備委員会 副委員長
          • From 01 Oct. 2020, To 30 Sep. 2026
            総長
          • From 01 Oct. 2014, To 30 Sep. 2020
            京都大学産学共同実用化促進事業実施委員会 委員
          • From 01 Oct. 2020, To 30 Sep. 2026
            役員会
          • From 01 Oct. 2020, To 30 Sep. 2026
            京都大学経営協議会
          • From 01 Oct. 2020, To 30 Sep. 2026
            教育研究評議会 評議員
          • From 01 Oct. 2020, To 30 Sep. 2026
            部局長会議
          • From 01 Oct. 2020, To 30 Sep. 2026
            研究科長部会

          Faculty management (title, position)

          • From 01 Oct. 2007, To 31 Oct. 2008
            医学研究科附属ゲノム医学センター長
          • From 12 Apr. 2012, To 11 Apr. 2014
            京都大学「医学領域」産学連携推進機構会議
          • From 01 Oct. 2010, To 30 Sep. 2014
            人事連絡委員会
          • From 01 Oct. 2008
            利益相反予備審査委員会
          • From 01 Oct. 2010, To 30 Sep. 2014
            動物実験施設管理委員会
          • From 01 Oct. 2010, To 30 Sep. 2014
            医学図書館運営委員会委員
          • From 01 Oct. 2010, To 30 Sep. 2014
            医学専攻長
          • From 01 Oct. 2010, To 30 Sep. 2014
            医学研究科・医学部将来計画検討委員会
          • 医学研究科・医学部放射性同位元素等管理委員会
          • From 01 Oct. 2010, To 30 Sep. 2014
            医学研究科学術情報システム・情報セキュリティ委員会
          • From 01 Oct. 2011, To 30 Sep. 2014
            医学研究科等防犯カメラ設置運用委員会
          • From 10 May 2012, To 30 Sep. 2014
            医学部学務委員会
          • From 01 Apr. 2010, To 31 Mar. 2015
            寄附講座運営委員会（免疫ゲノム医学）
          • To 30 Sep. 2015
            「次世代免疫制御を目指す創薬医学融合拠点」機構運営委員会
          • To 30 Sep. 2015
            「次世代免疫制御を目指す創薬医学融合拠点」研究推進委員会
          • To 30 Sep. 2015
            「次世代免疫制御を目指す創薬医学融合拠点」開発推進委員会

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