Hypertension research : official journal of the Japanese Society of Hypertension, 12 Jan. 2024, Peer-reviewed, Lead author, Corresponding author
Successful cardiac synchronization therapy device upgrade using an active fixation quadripolar pacing lead in a patients with persistent left superior vena cava and absent right superior vena cava.
Shushi Nishiwaki; Satoshi Shizuta; Munekazu Tanaka; Hirohiko Kohjitani; Koh Ono
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 02 Mar. 2023, Peer-reviewed
A case of preexcitation syndrome showing atypical atrioventricular nodal reentrant tachycardia and orthodromic atrioventricular reciprocating tachycardia with a bystander concealed nodoventricular/nodofascicular pathway.
Complex aberrant splicing in the induced pluripotent stem cell-derived cardiomyocytes from a patient with long QT syndrome carrying KCNQ1-A344Aspl mutation
Human molecular genetics, 01 May 2017, Peer-reviewed
Patient-Specific Human Induced Pluripotent Stem Cell Model Assessed with Electrical Pacing Validates S107 as a Potential Therapeutic Agent for Catecholaminergic Polymorphic Ventricular Tachycardia.
Predicting measurement continuity in home blood pressure monitoring using machine learning
Hirohiko Kohjitani
Hypertension Research, 2025
Analysis of reconduction after cavotricuspid isthmus ablation based on computed tomography anatomy and procedural factors with emphasis on catheter stability
Hirohiko Kohjitani
Journal of Interventional Cardiac Electrophysiology, 2025
Predicting rheumatoid arthritis progression from seronegative undifferentiated arthritis using machine learning: a deep learning model trained on the KURAMA cohort and externally validated with the ANSWER cohort
Significance of cell-specific precise computer simulation using new mathematical models of human induced pluripotent stem cell derived cardiomyocyte in drug testing
心不全患者における退院後のトルバプタン使用は2年目までの再入院に対する予測因子である 説明可能な人工知能に基づく研究(Post-discharge Use of Tolvaptan in Patients with Heart Failure as a Predictor of 2-year Rehospitalization: Explainable Artificial-Intelligence Based Study)
DEVELOPMENT OF DEEP-NEURAL NETWORK BASED ARTIFICIAL INTELLIGENCE MODELS FOR IDENTIFICATION OF PULMONARY VEIN POTENTIALS FROM 12-LEADS ELECTROCARDIOGRAM OF PATIENTS WITH ATRIAL FIBRILLATION
A CASE OF REPEATED DELAYED SEVERE PERICARDIAL EFFUSION AFTER LEADLESS PACEMAKER IMPLANTATION FOR ADVANCED ATRIOVENTRICULAR BLOCK AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION
YONEDA Fumiya; SHIZUTA Satoshi; NAKA Misaki; INOUE Tomoyuki; MORINAGA Akifumi; TANAKA Munekazu; NISHIWAKI Shushi; KOHJITANI Hirohiko; ONO Ko
日本不整脈心電学会学術大会プログラム・抄録集(Web), 2023
THE ACCURACY DIFFERENCES IN DEVELOPING A DEEP NEURAL NETWORK TO IDENTIFY PULMONARY VEIN POTENTIALS DEPEND ON INPUT LEADS OF A 12-LEAD ELECTROCARDIOGRAM
遺伝性不整脈疾患の遺伝的リスクの予測および予後層別化を目指したfine-tuningを用いた深層生成モデルの開発(Development of Deep-Generative Models with Fine-tuning Techniques for Genetic Risk Prediction and Prognosis Stratification of Hereditary Arrhythmic Disease)
Late Sodium Current Inhibitor Shortens Prolonged Action Potential Durations in iPS Cell-derived Cardiomyocytes of long QT syndrome associated with Cav 1.2 Ion Selectivity Disruption
Single Cell Electrophysiological Analysis of iPS Cell-Derived Cardiomyocytes Generated from Long-QT Syndrome Patients Carrying a CALM2 Mutation Using a Membrane Potential Imaging System
Impaired response of KCNQ1 channel to beta-adrenergic stimulation in human iPSC-derived cardiomyocytes carrying a CALM2-N98S mutation associated with long QT syndrome
遺伝性不整脈に対するオーダーメイド医療の現在の概観 iPS細胞を用いたリアノジン受容体遺伝子異常による遺伝性不整脈のモデリング(Current Perspective on Precision Medicine of Inherited Arrhythmias Modeling Inherited Arrhythmias Associated with Ryanodine Receptor Dysfunction Using iPS Cells)
QT延長症候群に関連するCALM2-N98S変異はヒトiPSC由来心筋細胞におけるβ-アドレナリン刺激に対するKCNQ1チャネルの応答を損なう(CALM2-N98S Mutation Associated with Long QT Syndrome Impaired the Response of KCNQ1 Channel to Beta-adrenergic Stimulation in Human iPSC-derived Cardiomyocytes)
人工知能による細胞特異的hiPSC-CMsのシミュレーションと薬物試験予測の最適化手法(Artificial Intelligence Based Optimization System for Cell-specific hiPSC-CMs Simulation and Prediction of Drug Testing)
LMNA-Related Cardiomyopathy Specific Induced-Pluripotent Stem Cells-derived Cardiomyocytes Stressed by Adrenergic Stimulation Recapitulate the Aging-Related Phenotype in an Early-Phase of Differentiation
Modeling inherited arrhythmias using human induced pluripotent stem cell-derived cardiomyocytes: Diagnostic tools, investigation of pathogenic mechanisms, development of new therapeutic approaches.
心筋L型カルシウムチャネルのイオン選択性を阻害するCACNA1C-E1115KのヒトiPS細胞モデル(Human Induced Pluripotent Stem Cell Model of CACNA1C-E1115K which Impairs Ion Selectivity of the Cardiac L-type Calcium Channel)
複雑な疾患メカニズムの解明における数理モデルとiPS細胞を利用した細胞工学を組み合わせた技術の有用性(Usefulness of Combination of Mathematical Modeling and Cell Engineering Using Induced Pluripotent Stem Cells for Revealing Complex Disease Mechanism)
NRDC regulates sinus automaticity through transcriptional regulation of ionchannels
大野美紀子; 松浦博; 牧山武; 糀谷泰彦; 西清人; 松田真太郎; 木村剛; 西英一郎
日本循環薬理学会口演要旨集, 2021
CALM2-N98S Mutation Associated with Long QT Syndrome Impaired the Response of KCNQ1 Channel to Beta-adrenergic Stimulation in Human iPSC-derived Cardiomyocytes
Usefulness of Combination of Mathematical Modeling and Cell Engineering Using Induced Pluripotent Stem Cells for Revealing Complex Disease Mechanism(和訳中)
Journal of Physiological Sciences (Web), Mar. 2020
CACNA1C-E1115K Mutation Associated with Overlap Phenotype of Long-QT and Brugada Syndrome Disrupts Cav 1.2 Ion Selectivity in Patient-specific iPS Cell-derived Cardiomyocytes
KCNQ1 Channel Dysfunction in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Carrying a CALM2-N98S Mutation Associated With Long QT Syndrome
hiPSC-CMシミュレーションのアルゴリズム的自動再生システムと薬剤検査の予測(Algorithmic Auto-recreation System of hiPSC-CMs Simulation and Prediction of Drug Testing)
糀谷 泰彦
日本循環器学会学術集会抄録集, Mar. 2019
Modeling Overlapping Phenotypes of Long-QT and Brugada Syndrome with CACNA1C-E1115K that Alters Ion Selectivity of the Cardiac L-Type Calcium Channel Using Induced Pluripotent Stem Cells
Structural Insights into Catecholaminergic Polymorphic Ventricular Tachycardia-Associated RyR2 Mutant Channels Using a Three-Dimensional In Silico Model
Development of Homozygous LaminA/C Deficient Human Induced Pluripotent Stem Cell Model for Analyzing the Pathophysiological Mechanism of Lamin A/C-related Cardiomyopathy
hiPSC-CMの細胞特異的で精密な数学的モデリングによりIKr遮断試験における二つの正反対のAPD反応が明らかになった(Cell-Specific Precise Mathematical Modeling of hiPSC-CMs Revealed Two Opposite APD Reaction in IKr Blocking Test)
SCN5A-D1275N関連性心筋ナトリウムチャネロパチーのヒトiPSC由来心筋細胞モデルから、蛋白質分解の亢進によってナトリウム電流が低下することが判明した(Human iPSC-Derived Myocyte Model of SCN5A-D1275N-Related Cardiac Sodium Channelopathy Reveals Diminished Sodium Currents Resulting from Enhanced Protein Degradation)
Human iPSC-Derived Myocyte Mmodel of SCN5A-D1275N-Related Cardiac Sodium Channelopathy Reveals Diminished Sodium Currents Resulting From Enhanced Protein Degradation
L型Ca2+チャネル遺伝子変異によるQT延長症候群iPS細胞モデルにおいて、l-cis-DiltiazemはCaチャネル不活性化を改善した(l-cis-diltiazem rescues impaired calcium channel inactivation in an iPSC-model of CACNA1Cassociated long-QT syndrome)
lL-cis-Diltiazem Ameliorates Impaired Calcium Channel Inactivation in a Patient-Specific Stem Cell Model of Long-QT Syndrome with a Calmodulin Mutation
Basic Cardiovascular Science Best Abstract Award: Allele-specific Disruption Rescues Electrophysiological Abnormalities in Human iPS Cell Model of Long-QT Syndrome With a CALM2 Mutation
Basic Cardiovascular Science Best Abstract Award: Allele-specific Disruption Rescues Electrophysiological Abnormalities in Human iPS Cell Model of Long-QT Syndrome With a CALM2 Mutation
In-silico systems for iPS cell-derived cardiomyocytes: needs and potential
Hirohiko Kohjitain
BioMecForum21, 07 Dec. 2024, Invited
Post-discharge Use of Tolvaptan in Patients with Heart Failure as a Predictor of 2-year Rehospitalization: Explainable Artificial-Intelligence Based Study
複雑な疾患メカニズムの解明における数理モデルとiPS細胞を利用した細胞工学を組み合わせた技術の有用性(Usefulness of Combination of Mathematical Modeling and Cell Engineering Using Induced Pluripotent Stem Cells for Revealing Complex Disease Mechanism)
人工知能による細胞特異的hiPSC-CMsのシミュレーションと薬物試験予測の最適化手法(Artificial Intelligence Based Optimization System for Cell-specific hiPSC-CMs Simulation and Prediction of Drug Testing)
hiPSC-CMの細胞特異的で正確な数理モデルによって明らかにしたIKr電流遮断試験における二つのAPD反作用(Cell-specific Precise Mathematical Modeling of hiPSC-CMs Revealed Two Opposite APD Reaction in IKr Blocking Test)
The Journal of Physiological Sciences, Mar. 2018, (一社)日本生理学会
hiPSC-CMの細胞特異的で精密な数学的モデリングによりIKr遮断試験における二つの正反対のAPD反応が明らかになった(Cell-Specific Precise Mathematical Modeling of hiPSC-CMs Revealed Two Opposite APD Reaction in IKr Blocking Test)
ヒトiPS由来心筋細胞の数理モデルの構築と心室筋・心房筋・洞結節様細胞の解析(Mathematical modeling and analysis of electrophysiological characteristics of the ventricular, atrial, and nodal-like hiPSC-CMs)
CIRCULATION, Nov. 2013, LIPPINCOTT WILLIAMS & WILKINS
致死性の不整脈に対するアミオダロンの退薬の必要性(Requirement of Discontinuation of Amiodarone for Lethal Arrhythmias)
Kohjitani Hirohiko; Kobori Atsushi; Sasaki Yasuhiro; Kim Kitae; Kitai Takeshi; Ehara Natsuhiko; Kinoshita Makoto; Kaji Shuichiro; Tani Tomoko; Furukawa Yutaka
Journal of Arrhythmia, Jun. 2013, (一社)日本不整脈心電学会
植込み型除細動器使用患者におけるJ波の頻度と部位(Prevalence and Location of J-wave in Patients with Implantable Cardioverter Defibrillator)
Kohjitani Hirohiko; Kobori Atsushi; Kim Kite; Kitai Takeshi; Ehara Natsuhiko; Kinoshita Makoto; Kaji Shuichiro; Tani Tomoko; Furukawa Yutaka; Kita Toru
Circulation Journal, Mar. 2013, (一社)日本循環器学会
冠動脈・大動脈造影検査中に可逆性後頭葉白質脳症(PRES)を発症した1例(Posterior reversible encephalopathy syndrome (PRES) as a rare complication of coronary/aortic angiography: A case report)
Kohjitani Hirohiko; Ehara Natsuhiko; Kim Kitae; Kitai Takeshi; Kobori Atsushi; Kinoshita Makoto; Kaji Shuichiro; Yamamuro Atsushi; Tani Tomoko; Furukawa Yutaka
アミオダロン静注から内服に切り替えた致死的不整脈症例の特徴(Characteristics of Lethal Arrhythmia Cases Switched from Intravenous to Internal Use of Amiodarone)
Kohjitani Hirohiko; Kobori Atsushi; Kim Kite; Kitai Takeshi; Kinoshita Makoto; Kaji Shujiro; Yamamuro Atsushi; Tani Tomoko; Furukawa Yutaka
心電図, Sep. 2011, (一社)日本不整脈心電学会
Usefulness of Combination of Mathematical Modeling and Cell Engineering Using Induced Pluripotent Stem Cells for Revealing Complex Disease Mechanism(和訳中)