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Tamura, Tomonori

Graduate School of Engineering, Division of Synthetic Chemistry and Biological Chemistry Senior Lecturer/ Junior Associate Professor

Tamura, Tomonori
list
    Last Updated :2024/04/23

    Basic Information

    Faculty

    • Faculty of Engineering

    Concurrent Affiliation

    • Center for the Promotion of Interdisciplinary Education and Research (C-PiER), スーパーグローバルコース 化学系ユニット

    Academic Degree

    • 修士(工学)(京都大学)
    • 博士(工学)(京都大学)

    ID,URL

    researchmap URL

    list
      Last Updated :2024/04/23

      Research

      Research Areas

      • Life sciences, Bioorganic chemistry

      Papers

      • Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes
        野中 洋; 美野 丈晴; 坂本 清志; Jae Hoon Oh; 渡邉 侑; 石川 守; 對馬 暁洋; 天池 一真; 清中 茂樹; 田村 朋則; A. Radu Aricescu; 掛川 渉; 三浦 会里子; 柚崎 通介; 浜地 格
        Chem, Feb. 2023, Peer-reviewed
      • Concomitant Mitral Regurgitation in Severe Aortic Stenosis-A Report From the CURRENT AS Registry
        R Murai; Y Kawase; T Taniguchi; T Morimoto; K Kadota; M Ohya; T Shimada; T Maruo; Y Fuku; T Komiya; K Ando; M Hanyu; N Kanamori; T Aoyama; K Murata; T Onodera; F Yamazaki; T Kitai; Y Furukawa; T Koyama; M Miyake; C Izumi; Y Nakagawa; K Yamanaka; H Mitsuoka; M Shirotani; M Kato; S Miki; H Nakajima; Y Hirano; S Miyazaki; T Saga; S Sugioka; S Matsuda; M Matsuda; T Ogawa; K Nagao; T Inada; S Nakayama; H Mabuchi; Y Takeuchi; H Sakamoto; G Sakaguchi; K Yamane; H Eizawa; M Toyofuku; T Tamura; A Iwakura; M Ishii; M Akao; K Shiraga; E Minamino-Muta; T Kato; M Inoko; K Ueyama; T Ikeda; Y Himura; A Komasa; K Ishii; K Hotta; Y Sato; K Fujiwara; Y Kato; I Kouchi; Y Inuzuka; S Ikeguchi; S Miwa; C Maeda; E Shinoda; J Nishizawa; T Jinnai; N Higashitani; M Kitano; Y Morikami; S Kitaguchi; K Minatoya; T Kimura
        CIRCULATION JOURNAL, Mar. 2022
      • システイン以外のアミノ酸残基を標的とする不可逆阻害薬
        田村 朋則
        日本薬理学雑誌, 2022
      • オルガネラ膜特異的なホスファチジルコリンのライブイメージング
        田村 朋則; 浜地 格
        実験医学, 2021
      • Endogenous Cell-Surface Receptor Modification by Metal Chelation-Assisted Pyridinium Oxime Catalyst
        Vikram Thimaradka; Hayata Utsunomiya; Tomonori Tamura; Itaru Hamachi
        Organic Letters, 22 Mar. 2023, Peer-reviewed, Corresponding author
      • Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes
        Hiroshi Nonaka; Takeharu Mino; Seiji Sakamoto; Jae Hoon Oh; Yu Watanabe; Mamoru Ishikawa; Akihiro Tsushima; Kazuma Amaike; Shigeki Kiyonaka; Tomonori Tamura; A. Radu Aricescu; Wataru Kakegawa; Eriko Miura; Michisuke Yuzaki; Itaru Hamachi
        Chem, Feb. 2023, Peer-reviewed
      • Chemical biology tools for imaging-based analysis of organelle membranes and lipids
        Tomonori Tamura; Itaru Hamachi
        Current Opinion in Chemical Biology, Oct. 2022, Peer-reviewed, Invited, Lead author, Corresponding author
      • Light-induced stabilization of microtubules by photo-crosslinking of a Tau-derived peptide
        Soei Watari; Hiroshi Inaba; Tomonori Tamura; Arif Md. Rashedul Kabir; Akira Kakugo; Kazuki Sada; Itaru Hamachi; Kazunori Matsuura
        Chemical Communications, 2022, Peer-reviewed, Invited
      • Organelle‐Selective Labeling of Choline‐Containing Phospholipids (CPLs) and Real‐Time Imaging in Living Cells
        Masaki Tsuchiya; Tomonori Tamura; Itaru Hamachi
        Current Protocols, 22 Apr. 2021, Peer-reviewed, Invited
      • Organelle-selective click labeling coupled with flow cytometry allows pooled CRISPR screening of genes involved in phosphatidylcholine metabolism.
        Masaki Tsuchiya; Nobuhiko Tachibana; Kohjiro Nagao; Tomonori Tamura; Itaru Hamachi
        Cell metabolism, 07 Mar. 2023
      • 内在性タンパク質に対する選択的ケミカルラベリングの新手法 : リガンド指向型トシル化学によるラベル化の可能性
        田村 朋則; 浜地 格
        化学と生物, 01 Mar. 2010
      • In Situ Protein Labeling in Complex Environments
        T. Tamura; H. Shigemitsu; I. Hamachi
        Comprehensive Supramolecular Chemistry II, 22 Jun. 2017, Peer-reviewed
      • Enhanced Suppression of a Protein–Protein Interaction in Cells Using Small-Molecule Covalent Inhibitors Based on an N-Acyl-N-alkyl Sulfonamide Warhead
        Tsuyoshi Ueda; Tomonori Tamura; Masaharu Kawano; Keiya Shiono; Fruzsina Hobor; Andrew J. Wilson; Itaru Hamachi
        Journal of the American Chemical Society, 31 Mar. 2021, Corresponding author
      • Site-specific covalent labeling of His-tag fused proteins with N-acyl-N-alkyl sulfonamide reagent
        Vikram Thimaradka; Jae Hoon Oh; Christina Heroven; A. Radu Aricescu; Michisuke Yuzaki; Tomonori Tamura; Itaru Hamachi
        Bioorganic & Medicinal Chemistry, Jan. 2021, Corresponding author
      • Organelle membrane-specific chemical labeling and dynamic imaging in living cells
        Tomonori Tamura; Alma Fujisawa; Masaki Tsuchiya; Yuying Shen; Kohjiro Nagao; Shin Kawano; Yasushi Tamura; Toshiya Endo; Masato Umeda; Itaru Hamachi
        Nature Chemical Biology, Dec. 2020, Lead author
      • Imaging and Profiling of Proteins under Oxidative Conditions in Cells and Tissues by Hydrogen-Peroxide-Responsive Labeling
        Hao Zhu; Tomonori Tamura; Alma Fujisawa; Yuki Nishikawa; Rong Cheng; Mikiko Takato; Itaru Hamachi
        Journal of the American Chemical Society, 16 Sep. 2020
      • Chemical Tools for Endogenous Protein Labeling and Profiling
        Kazuki Shiraiwa; Rong Cheng; Hiroshi Nonaka; Tomonori Tamura; Itaru Hamachi
        CELL CHEMICAL BIOLOGY, Aug. 2020, Peer-reviewed
      • Development of a Photoactivatable Proximity Labeling Method for the Identification of Nuclear Proteins
        Tomonori Tamura; Mikiko Takato; Keiya Shiono; Itaru Hamachi
        CHEMISTRY LETTERS, Feb. 2020, Peer-reviewed
      • Development of a Cell-Based Ligand-Screening System for Identifying Hsp90 Inhibitors
        Tsuyoshi Ueda; Tomonori Tamura; Itaru Hamachi
        BIOCHEMISTRY, Jan. 2020, Peer-reviewed
      • Development of a Nitric Oxide-Responsive Labeling Reagent for Proteome Analysis of Live Cells.
        Yuki Nishikawa; Takayuki Miki; Masashi Awa; Keiko Kuwata; Tomonori Tamura; Itaru Hamachi
        ACS chemical biology, 15 Mar. 2019, Peer-reviewed
      • Selective and reversible modification of kinase cysteines with chlorofluoroacetamides.
        Naoya Shindo; Hirokazu Fuchida; Mami Sato; Kosuke Watari; Tomohiro Shibata; Keiko Kuwata; Chizuru Miura; Kei Okamoto; Yuji Hatsuyama; Keisuke Tokunaga; Seiichi Sakamoto; Satoshi Morimoto; Yoshito Abe; Mitsunori Shiroishi; Jose M M Caaveiro; Tadashi Ueda; Tomonori Tamura; Naoya Matsunaga; Takaharu Nakao; Satoru Koyanagi; Shigehiro Ohdo; Yasuchika Yamaguchi; Itaru Hamachi; Mayumi Ono; Akio Ojida
        Nature chemical biology, Mar. 2019, Peer-reviewed
      • Chemistry for Covalent Modification of Endogenous/Native Proteins: From Test Tubes to Complex Biological Systems
        Tomonori Tamura; Itaru Hamachi
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2019, Peer-reviewed
      • Chemical proteomics for subcellular proteome analysis
        Hao Zhu; Tomonori Tamura; Itaru Hamachi
        CURRENT OPINION IN CHEMICAL BIOLOGY, Feb. 2019, Peer-reviewed
      • Chemical Profiling of the Endoplasmic Reticulum Proteome Using Designer Labeling Reagents.
        Alma Fujisawa; Tomonori Tamura; Yuki Yasueda; Keiko Kuwata; Itaru Hamachi
        Journal of the American Chemical Society, 12 Dec. 2018, Peer-reviewed
      • Rapid labelling and covalent inhibition of intracellular native proteins using ligand-directed N-Acyl-N-Alkyl sulfonamide
        Tomonori Tamura; Tsuyoshi Ueda; Taiki Goto; Taku Tsukidate; Yonatan Shapira; Yuki Nishikawa; Alma Fujisawa; Itaru Hamachi
        Nature Communications, 01 Dec. 2018, Peer-reviewed
      • コンディショナルプロテオミクスによる亜鉛周辺タンパク質のプロファイリング (特集 生体内金属の動態解明とその制御 : 分子から細胞,臨床まで)
        田村 朋則; 浜地 格
        生化学, Jun. 2018
      • In Situ Construction of Protein-Based Semisynthetic Biosensors
        Tsuyoshi Ueda; Tomonori Tamura; Itaru Hamachi
        ACS Sensors, 23 Mar. 2018, Peer-reviewed
      • Recognition-driven chemical labeling of endogenous proteins in multi-molecular crowding in live cells
        Kazuma Amaike; Tomonori Tamura; Itaru Hamachi
        CHEMICAL COMMUNICATIONS, Nov. 2017, Peer-reviewed
      • Affinity-Guided Oxime Chemistry for Selective Protein Acylation in Live Tissue Systems
        Tomonori Tamura; Zhining Song; Kazuma Amaike; Shin Lee; Sifei Yin; Shigeki Kiyonaka; Itaru Hamachi
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Oct. 2017, Peer-reviewed
      • A Set of Organelle-Localizable Reactive Molecules for Mitochondrial Chemical Proteomics in Living Cells and Brain Tissues.
        Yuki Yasueda; Tomonori Tamura; Alma Fujisawa; Keiko Kuwata; Shinya Tsukiji; Shigeki Kiyonaka; Itaru Hamachi
        Journal of the American Chemical Society, 22 Jun. 2016, Peer-reviewed
      • Recent Advance in Organic Chemistry for Protein Labeling under Live Cell Conditions
        Yuki Nishikawa; Tomonori Tamura; Itaru Hamachi
        JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, May 2016, Peer-reviewed
      • Nucleus-selective Chemical Proteomics Using Hoechst-tagged Reactive Molecules
        Yuki Yasueda; Tomonori Tamura; Itaru Hamachi
        CHEMISTRY LETTERS, Mar. 2016, Peer-reviewed
      • Biomembrane-embedded Catalysts for Membrane-associated Protein Labeling on Red Blood Cells
        Yuki Yasueda; Tomonori Tamura; Keiko Kuwara; Yousuke Takaoka; Itaru Hamachi
        CHEMISTRY LETTERS, Dec. 2015, Peer-reviewed
      • Analysis of Cell-Surface Receptor Dynamics through Covalent Labeling by Catalyst-Tethered Antibody
        Takahiro Hayashi; Yuki Yasueda; Tomonori Tamura; Yousuke Takaoka; Itaru Hamachi
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2015, Peer-reviewed
      • Extended Affinity-guided DMAP Chemistry with a Finely Tuned Acyl Donor for Intracellular FKBP12 Labeling
        Zhining Song; Yousuke Takaoka; Yoshiyuki Kioi; Kazuhiro Komatsu; Tomonori Tamura; Takayuki Miki; Itaru Hamachi
        CHEMISTRY LETTERS, Mar. 2015, Peer-reviewed
      • Labeling proteins by affinity-guided dmap chemistry
        Tomonori Tamura; Itaru Hamachi
        Site-Specific Protein Labeling: Methods and Protocols, 05 Jan. 2015, Peer-reviewed
      • Recent Progress in Design of Protein-Based Fluorescent Biosensors and Their Cellular Applications
        Tomonori Tamura; Itaru Hamachi
        ACS CHEMICAL BIOLOGY, Dec. 2014, Peer-reviewed
      • Live cell off-target identification of lapatinib using ligand-directed tosyl chemistry.
        Yamaura K; Kuwata K; Tamura T; Kioi Y; Takaoka Y; Kiyonaka S; Hamachi I
        Chemical communications (Cambridge, England), Nov. 2014, Peer-reviewed
      • Semisynthetic lectin-4-dimethylaminopyridine conjugates for labeling and profiling glycoproteins on live cell surfaces.
        Hayashi T; Sun Y; Tamura T; Kuwata K; Song Z; Takaoka Y; Hamachi I
        Journal of the American Chemical Society, Aug. 2013, Peer-reviewed
      • Fluorophore labeling of native FKBP12 by ligand-directed tosyl chemistry allows detection of its molecular interactions in vitro and in living cells
        T. Tamura; Y. Kioi; T. Miki; S. Tsukiji; I. Hamachi
        Journal of the American Chemical Society, May 2013, Peer-reviewed
      • Native FKBP12 engineering by ligand-directed tosyl chemistry: Labeling properties and application to photo-cross-linking of protein complexes in vitro and in living cells
        T. Tamura; S. Tsukiji; I. Hamachi
        Journal of the American Chemical Society, Feb. 2012, Peer-reviewed
      • Quenched ligand-directed tosylate reagents for one-step construction of turn-on fluorescent biosensors
        S. Tsukiji; H. Wang; M. Miyagawa; T. Tamura; Y. Takaoka; I. Hamachi
        Journal of the American Chemical Society, Jul. 2009, Peer-reviewed
      • Ligand-directed tosyl chemistry for protein labeling in vivo
        S. Tsukiji; M. Miyagawa; Y. Takaoka; T. Tamura; I. Hamachi
        Nature Chemical Biology, May 2009, Peer-reviewed

      Misc.

      • 4価型人工ペプチドを用いたホスファチジン酸結合プローブの開発
        小川 莉奈; 長尾 耕治郎; 原 雄二; 田村 朋則; 浜地 格; 井上 飛鳥; 青木 淳賢; 高橋 美帆; 西川 喜代孝; 梅田 真郷
        脂質生化学研究, May 2015
      • 生体金属動態の分子科学-「生命金属科学」への展開 コンディショナルプロテオミクスによる亜鉛関連タンパク質群の同定
        田村 朋則; 三木 卓幸; 西川 雄貴; 清中 茂樹; 若林 真樹; 石濱 泰; 浜地 格
        生命科学系学会合同年次大会, Dec. 2017
      • コンディショナルプロテオミクスによる亜鉛関連タンパク質群の同定
        田村朋則; 三木卓幸; 西川雄貴; 清中茂樹; 若林真樹; 石濱泰; 浜地格; 浜地格
        日本生化学会大会(Web), 2017
      • 生命金属ダイナミクス : 生体内における金属の挙動と制御
        古川, 良明; 神戸, 大朋; 城, 宜嗣; 津本, 浩平, Contributor
        エヌ・ティー・エス, Jan. 2021

      Awards

      • 23 Mar. 2020
        日本化学会, 第69回日本化学会進歩賞
      • Apr. 2019
        日本化学会, 第99回日本化学会春季年会 優秀講演賞(学術)
      • Sep. 2017
        日本化学会 生体機能関連化学部会, 第11回バイオ関連化学シンポジウム部会 講演賞
      • Feb. 2016
        井上科学振興財団, 第32回井上研究奨励賞
      • Apr. 2012
        日本化学会, 第92回日本化学会春季年会 学生講演賞

      External funds: Kakenhi

      • オルガネラ代謝物の化学標識による時空間メタボローム解析
        Grant-in-Aid for Scientific Research (B)
        Basic Section 37010:Bio-related chemistry
        Kyoto University
        田村 朋則
        From 01 Apr. 2021, To 31 Mar. 2025, Granted
        オルガネラ;メタボロミクス;代謝物
      • 生命金属動態の理解に向けた金属イオンConditionalプロテオミクス法の開発
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Complex systems
        Kyoto University
        田村 朋則
        From 28 Jun. 2019, To 31 Mar. 2024, Granted
        コンディショナルプロテオミクス;生命金属;銅;タンパク質修飾
      • Development of a novel chemical modification method to enable electron microscopic observation of voltage-dependent calcium channels
        Grant-in-Aid for Early-Career Scientists
        Basic Section 37010:Bio-related chemistry
        Kyoto University
        Tomonori Tamura
        From 01 Apr. 2018, To 31 Mar. 2020, Project Closed
        カルシウムチャネル;神経;可視化;P/Q型Ca2+チャネル;タンパク質化学修飾;電子顕微鏡;P/Q型カルシウムチャネル;蛍光イメージング;ケミカルバイオロジー
      • Development of novel protein chemical modification method for imaging analysis of endogenous protein-protein interaction in live cells
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Tomonori Tamura
        From 01 Apr. 2015, To 31 Mar. 2017, Project Closed
        タンパク質化学修飾;タンパク質ラベリング;蛋白質化学修飾;細胞内有機化学;蛍光イメージング;FKBP12
      • Development of organic chemistry targeting biomolecules in live animals
        Grant-in-Aid for Specially Promoted Research
        Science and Engineering
        Kyoto University
        浜地 格
        From 01 Apr. 2023, To 31 Mar. 2028, Granted
        分子夾雑;生命化学;脳内有機化学;リガンド指向性化学;ケミカルバイオロジー
      list
        Last Updated :2024/04/23

        Education

        Teaching subject(s)

        • From 01 Apr. 2023, To 31 Mar. 2024
          Analytical Chemistry II (Advanced Chemistry)
          7431, Spring, Faculty of Engineering, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Biochemical Engineering
          7030, Fall, Faculty of Engineering, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Advanced Biological Chemistry 2 Continued
          P836, Spring, Graduate School of Engineering, 1
        • From 01 Apr. 2023, To 31 Mar. 2024
          Advanced Biological Chemistry
          H836, Spring, Graduate School of Engineering, 3
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Biological Chemistry
          H836, Spring, Graduate School of Engineering, 3
        • From 01 Apr. 2022, To 31 Mar. 2023
          Biochemical Engineering
          7030, Fall, Faculty of Engineering, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Biological Chemistry 2 Continued
          P836, Spring, Graduate School of Engineering, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Analytical Chemistry II (Advanced Chemistry)
          7431, Spring, Faculty of Engineering, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Bioorganic Chemistry
          H813, Fall, Graduate School of Engineering, 1.5
        • From 01 Apr. 2022, To 31 Mar. 2023
          Chemical Basis of Life(Advanced Chemistry)
          7426, Fall, Faculty of Engineering, 2
        • From Apr. 2020, To Mar. 2021
          Advanced Biological Chemistry
          Spring, 工学研究科
        • From Apr. 2020, To Mar. 2021
          Advanced Biological Chemistry 2 Continued
          Spring, 工学研究科
        • From Apr. 2020, To Mar. 2021
          Analytical Chemistry II (Fundamental Chemistry)
          Spring, 工学部
        • From Apr. 2020, To Mar. 2021
          Chemical Basis of Life(Fundamental Chemistry)
          Fall, 工学部
        • From Apr. 2020, To Mar. 2021
          Biochemical Engineering
          Fall, 工学部
        • From Apr. 2020, To Mar. 2021
          Bioorganic Chemistry
          Fall, 工学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced Biological Chemistry
          Spring, 工学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced Biological Chemistry 2 Continued
          Spring, 工学研究科
        • From Apr. 2021, To Mar. 2022
          Analytical Chemistry II (Advanced Chemistry)
          Spring, 工学部
        • From Apr. 2021, To Mar. 2022
          Chemical Basis of Life(Advanced Chemistry)
          Fall, 工学部
        • From Apr. 2021, To Mar. 2022
          Biochemical Engineering
          Fall, 工学部

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