Basic Information

Email Address

• Email Address

  imamura.tomohiko.5wkyoto-u.ac.jp

Professional Memberships

• From Dec. 2020, To Present

  Japanese Society for the Prevention of Sudden and Unexpected Death in Children
• Japan Pediatric Society
• Japanese Circulation Society
• Japanese Society of Pediatric Cardiology and Cardiac Surgery
• Japanese Heart Rhythm Society

Academic Degree

• 25 Nov. 2025

  京都大学博士（医学）
• 24 Mar. 2025

  京都大学社会健康医学修士（専門職）

Academic Resume (Graduate Schools)

• 京都大学, 大学院医学研究科博士課程医学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 長崎大学, 医学部医学科（２年次編入学）, 卒業
• 九州大学, 薬学部総合薬学科, 卒業

High School

• High School

  Kajiki High School

Research History

• From Apr. 2025, To Present

  Kyoto University, Department of Preventive Services, School of Public Health, Program-specific assistant professor
• From Apr. 2017, To Mar. 2019

  Saitama Medical University International Medical Center, Department of Pediatric Cardiology, Assistant Professor
• From Apr. 2014, To Mar. 2017

  Kanagawa Chidren's Medical Center, Junior resident for Pediatrics
• From Apr. 2012, To Mar. 2014

  Kagoshima Medical Center, Resident

Profile

• Profile

  Certified Pediatrician/Instructor, Certified Cardiologist, Pharmacist

  
  

  
  ・Clinical and electrophysiological risk assessment of fatal inherited arrhythmias in childhood
  ・Sudden unexpected death in infancy and childhood (SUDI and SUDC)
  ・Development of novel devices for sudden death prevention (millimeter-wave radar non-contact vital monitor and monitoring system using PHR)
  ・Analysis of sudden pediatric death using the nationwide out-of-hospital cardiac arrest registry
  ・Investigation of SUDI and SUDC causes (Child Death Review, genetic testing, myocardial pathology, omics analysis)
  ・Narrative research with bereaved families (lived experience and support needs)
  ・Infrastructure development for push-type bereavement support

ID,URL

• J-Global ID

  201701015859445711

researchmap URL

• https://researchmap.jp/7000021488

Research

Research Interests

• bereavement support
• sudden infant death syndrome
• Long QT syndrome
• Arrhythmogenic right ventricular cardiomyopathy
• Brugada syndrome
• Inherited arrhythmia
• Pediatric cardiology
• Pediatrics

Research Areas

• Life sciences, Hygiene and public health (non-laboratory)
• Life sciences, Cardiology, Arrhythmia
• Life sciences, Physiology, Cardiac Electrophysiology
• Life sciences, Fetal medicine/Pediatrics, Pediatric Cardiology

Papers

• ドクターヘリで搬送された院外心停止患者における胸骨圧迫法(用手vs機械式)と予後の関連

  森 仁志; 西岡 典宏; 今村 知彦; 吉村 有矢; 石見 拓

  日本航空医療学会雑誌, Oct. 2025

  
• 院外心停止患者に対するドクターヘリ搬送と陸上搬送の比較検討

  森 仁志; 西岡 典宏; 今村 知彦; 吉村 有矢; 石見 拓

  日本航空医療学会雑誌, Oct. 2025

  
• デジタルヘルスの未来を担うPersonal Health Records(PHR)データの流通促進にむけた取り組み AMED「医療高度化に資する分散管理型PHRデータ流通基盤に関する研究開発」PHRデータ流通の実証

  島本 大也; 西岡 典弘; 今村 知彦; 吉村 聡志; 立山 由紀子; 難波 真人; 石見 拓

  医療情報学連合大会論文集, Nov. 2024

  
• Temporal Trends in Outcomes After Out-of-Hospital Cardiac Arrest Transported to Critical Care Medical Centers in Japan, 2014-2022: A Nationwide Retrospective Observational Study.

  Tadaharu Shiozumi; Tasuku Matsuyama; Tomohiko Imamura; Norihiro Nishioka; Takeyuki Kiguchi; Tetsuhisa Kitamura; Taku Iwami

  Critical care medicine, 18 Mar. 2026, Peer-reviewed

  
• Impact of the COVID-19 pandemic on favourable neurological outcome after EMS-witnessed out-of-hospital cardiac arrest: a prospective nationwide observational study.

  Takefumi Tsunemitsu; Norihiro Nishioka; Tomohiko Imamura; Tomonari Shimamoto; Tasuku Matsuyama; Takeyuki Kiguchi; Kosuke Kiyohara; Chika Nishiyama; Tetsuhisa Kitamura; Yoshimitsu Takahashi; Taku Iwami

  Resuscitation, 07 Aug. 2025

  
• SCN5A variant type-dependent risk prediction in Brugada syndrome

  Takanori Aizawa; Takeru Makiyama; Hai Huang; Tomohiko Imamura; Megumi Fukuyama; Keiko Sonoda; Koichi Kato; Takashi Hisamatsu; Yuko Nakamura; Kenji Hoshino; Junichi Ozawa; Hiroshi Suzuki; Kazushi Yasuda; Hisaaki Aoki; Takashi Kurita; Yoko Yoshida; Tsugutoshi Suzuki; Yoshihide Nakamura; Yoshiharu Ogawa; Shintaro Yamagami; Hiroshi Morita; Shinsuke Yuasa; Masakazu Fukuda; Makoto Ono; Hidekazu Kondo; Naohiko Takahashi; Seiko Ohno; Yoshihisa Nakagawa; Koh Ono; Minoru Horie

  Europace, 05 Feb. 2025

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• Sex-specific clinical course of young patients with Brugada syndrome

  Tomohiko Imamura; Takeru Makiyama; Junichi Ozawa; Keiko Sonoda; Koichi Kato; Takanori Aizawa; Asami Kashiwa; Jingshan Gao; Hai Huang; Yuta Yamamoto; Hirohiko Kohjitani; Hisaaki Aoki; Seiichi Watanabe; Shota Muraji; Takuro Kojima; Masao Yoshinaga; Seiko Ohno; Hiroshi Suzuki; Naokata Sumitomo; Yoshihisa Nakagawa; Koh Ono; Minoru Horie; Takeshi Kimura

  European Heart Journal, 05 Feb. 2025, Peer-reviewed, Lead author

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• Strategies for Reducing Sudden Cardiac Death by Raising Public Awareness ― A Statement From the Education and Implementation for Cardiac Emergency Committee of the Japanese Circulation Society ―

  Chika Nishiyama; Satoshi Yoshimura; Takuya Taniguchi; Tetsuya Amano; Hirohiko Ando; Yosuke Homma; Tomohiko Imamura; Tomonori Itoh; Takeyuki Kiguchi; Kosuke Kiyohara; Satomi Konno; Hisaki Makimoto; Tomohiro Manabe; Yasushi Matsuzawa; Hideo Mitamura; Nogiku Niwamae; Masashi Sakuma; Kayoko Sato; Yasuhiro Satoh; Yoshio Tahara; Kenichi Tsujita; Yayoi Tetsuou Tsukada; Masato Uchida; Yasunori Ueda; Taku Iwami

  Circulation Journal, 26 Dec. 2024

  
• 心疾患の発症機構解明と新たな治療戦略 iPS細胞を用いたカルモジュリン遺伝子異常による致死性不整脈疾患の病態解明(Elucidation of the pathogenesis of heart diseases and development of new therapeutic strategies Modeling calmodulin-related life-threatening arrhythmias using iPS cells)

  Makiyama Takeru; Gao Jingshan; Yamamoto Yuta; Kobayashi Takuya; Takanori Aizawa; Huang Hai; Kasahiwa Asami; Imamura Tomohiko; Aoki Hisaaki; Kato Koichi; Fukuyama Megumi; Toyoda Futoshi; Ohno Seiko; Makita Naomasa; Kurebayashi Nagomi; Murayama Takashi; Horie Miinoru; Kimura Takeshi; Ono Koh

  The Journal of Physiological Sciences, May 2024

  
• Brugada Syndrome and Arrhythmogenic Right Ventricular Cardiomyopathy

  Tomohiko Imamura; Takeru Makiyama

  Pediatric Cardiology and Cardiac Surgery, May 2024, Peer-reviewed, Invited, Lead author

  
• Fatal Arrhythmic Events are Higher in Non-missense than in Missense Variants in SCN5A-positive Brugada Syndrome(タイトル和訳中)

  Aizawa Takanori; Makiyama Takeru; Huang Hai; Imamura Tomohiko; Fukuyama Megumi; Sonoda Keiko; Kato Koichi; Ohno Seiko; Horie Minoru; Ono Koh

  日本循環器学会学術集会抄録集, Mar. 2024

  
• Histological Characteristics of a Rat Model of Cardiac Laminopathy Carrying Lmna p.S143P(タイトル和訳中)

  Huang Hai; Makiyama Takeru; Shirai Manabu; Wakabayashi Masaki; Yoshida Morikatsu; Nishiuchi Suguru; Moriuchi Kenji; Gao Jing Shan; Kashiwa Asami; Imamura Tomohiko; Aizawa Takanori; Kohjitani Hirohiko; Kato Koichi; Ohno Seiko; Nakagawa Yasuaki; Yamaguchi Osamu; Kuwahara Koichiro; Makita Naomasa; Horie Minoru; Kimura Takeshi; Ono Koh

  日本循環器学会学術集会抄録集, Mar. 2024

  
• Novel Calmodulin Variant p.E46K Associated With Severe Catecholaminergic Polymorphic Ventricular Tachycardia Produces Robust Arrhythmogenicity in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

  Jingshan Gao; Takeru Makiyama; Yuta Yamamoto; Takuya Kobayashi; Hisaaki Aoki; Thomas L Maurissen; Yimin Wuriyanghai; Asami Kashiwa; Tomohiko Imamura; Takanori Aizawa; Hai Huang; Hirohiko Kohjitani; Misato Nishikawa; Kazuhisa Chonabayashi; Megumi Fukuyama; Hiromi Manabe; Kouichi Nakau; Tsutomu Wada; Koichi Kato; Futoshi Toyoda; Yoshinori Yoshida; Naomasa Makita; Knut Woltjen; Seiko Ohno; Nagomi Kurebayashi; Takashi Murayama; Takashi Sakurai; Minoru Horie; Takeshi Kimura

  Circulation. Arrhythmia and electrophysiology, 03 Mar. 2023

  
• Non-missense variants of KCNH2 show better outcomes in type 2 long QT syndrome.

  Takanori Aizawa; Yuko Wada; Kanae Hasegawa; Hai Huang; Tomohiko Imamura; Jingshan Gao; Asami Kashiwa; Hirohiko Kohjitani; Megumi Fukuyama; Koichi Kato; Eri Toda Kato; Takashi Hisamatsu; Seiko Ohno; Takeru Makiyama; Takeshi Kimura; Minoru Horie

  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 02 Mar. 2023

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• ミスセンス変異Lmna-S143Pを有するLMNA関連心筋症のラットモデル(Rat Model of LMNA-related Cardiomyopathy Carrying a Missense Mutation, Lmna-S143P)

  Huang Hai; Makiyama Takeru; Shirai Manabu; Wakabayashi Masaki; Ishikawa Taisuke; Nishiuchi Suguru; Moriuchi Kenji; Gao Jingshan; Kashiwa Asami; Imamura Tomohiko; Aizawa Takanori; Kohjitani Hirohiko; Kato Koichi; Ohno Seiko; Nakagawa Yasuaki; Yamaguchi Osamu; Kuwahara Koichiro; Makita Naomasa; Horie Minoru; Kimura Takeshi

  日本循環器学会学術集会抄録集, Mar. 2023

  
• Genetic background and circumstances at death in sudden unexpected death in infancy

  今村知彦; 牧山武; 大野聖子; 堀江稔

  日本SIDS・乳幼児突然死予防学会誌, Dec. 2022, Peer-reviewed, Invited, Lead author

  
• Efficacy of SubcutAneous implantable cardioVErter-defibrillators in ≤ 18 year-old CHILDREN: SAVE-CHILDREN registry.

  Hitoshi Mori; Naokata Sumitomo; Kenta Tsutsui; Hideo Fukunaga; Hidemori Hayashi; Hiroshi Nakajima; Shota Muraji; Taisuke Nabeshima; Daisuke Kawano; Yoshifumi Ikeda; So Asano; Junichi Nitta; Shigeo Watanabe; Tatsunori Hokosaki; Seiichi Sato; Toshiyuki Chisaka; Takashi Higaki; Tadashi Nakajima; Shuntaro Tamura; Yoshiaki Kaneko; Kentaro Ikeda; Ayako Okada; Hideki Kobayashi; Hirohiko Motoki; Hitoshi Minamiguchi; Tomohiko Imamura; Satoshi Shizuta; Mitsuharu Kawamura; Yumi Munetsugu; Tsugutoshi Suzuki; Takashi Murakami; Hitoshi Horigome; Tsutomu Wada; Motoki Takamuro; Junichi Ozawa; Hiroshi Suzuki; Daisuke Izumi; Sou Otsuki; Masaomi Chinushi; Ken Kato; Masaru Miura; Jun Maeda; Masato Fukunaga; Hidekazu Kondo; Naohiko Takahashi; Takeshi Tobiume; Itsuro Morishima; Kenji Kuraishi; Kentaro Nakamura; Hiroshi Hayashi; Hirohiko Suzuki; Yukihiko Yoshida; Seiji Fukamizu; Rintaro Hojo; Norihito Nuruki; Masao Yoshinaga; Kentaro Hayashi; Hidehira Fukaya; Jun Kishihara; Toshiki Kobayashi; Ritsushi Kato

  International journal of cardiology, 07 Sep. 2022

  
• Disrupted Cav1.2 selectivity causes overlapping long QT and Brugada syndrome phenotypes in the CACNA1C-E1115K iPS cell model.

  Asami Kashiwa; Takeru Makiyama; Hirohiko Kohjitani; Thomas L Maurissen; Taisuke Ishikawa; Yuta Yamamoto; Yimin Wuriyanghai; Jingshan Gao; Hai Huang; Tomohiko Imamura; Takanori Aizawa; Misato Nishikawa; Kazuhisa Chonabayashi; Hiroyuki Mishima; Seiko Ohno; Futoshi Toyoda; Seiichi Sato; Koh-Ichiro Yoshiura; Kazuhiro Takahashi; Yoshinori Yoshida; Knut Woltjen; Minoru Horie; Naomasa Makita; Takeshi Kimura

  Heart rhythm, 23 Aug. 2022

  
• 機械学習を用いた遺伝性不整脈疾患の予後予測モデルの開発(Development of a Genetic Prognostic Model for Hereditary Arrhythmia Disease Using Machine Learning)

  Kohjitani Hirohiko; Mitani Takeshi; Aizawa Takanori; Makiyama Takeru; Kashiwa Asami; Imamura Tomohiko; Ohno Seiko; Horie Minoru; Shizuta Satoshi; Kimura Takeshi; Okuno Yasushi

  日本循環器学会学術集会抄録集, Mar. 2022

  
• KCNH2のhaploinsufficient variantとQT延長症候群2型患者における良好な不整脈予後(Haploinsufficient Variant of KCNH2 Cause Better Arrhythmia Outcome in Patients with Type 2 Long QT Syndrome)

  Aizawa Takanori; Wada Yuko; Makiyama Takeru; Huang Hai; Imamura Tomohiko; Gao Jingshan; Kashiwa Asami; Kohjitani Hirohiko; Kato Koichi; Ohno Seiko; Kimura Takeshi; Horie Minoru

  日本循環器学会学術集会抄録集, Mar. 2022

  
• CPVTに関連する新規カルモジュリン変異は変異体CaM-RyR2結合親和性の増加によりiPS細胞モデルでRyR2を介したCa2+リークを引き起こす(A Novel CPVT-associated Calmodulin Mutation Causes Ca2+ Leaks via RyR2 in iPSC Model Due to Increased Mutant CaM-RyR2 Binding Affinity)

  Gao Jingshan; Makiyama Takeru; Yamamoto Yuta; Kashiwa Asami; Imamura Tomohiko; Aizawa Takanori; Kohjitani Hirohiko; Kato Koichi; Ohno Seiko; Horie Minoru; Kimura Takeshi; Aoki Hisaaki; Makita Naomasa

  日本循環器学会学術集会抄録集, Mar. 2022

  
• 小児におけるブルガダ症候群の臨床的側面 性別と年齢が予後に与える影響(Clinical Aspects of Brugada Syndrome in Children: The Impact of Gender and Age on the Prognosis)

  今村 知彦; 牧山 武; 小澤 淳一; 相澤 卓範; 柏 麻美; 糀谷 泰彦; 加藤 浩一; 青木 寿明; 鈴木 博; 園田 桂子; 大野 聖子; 住友 直方; 堀江 稔; 木村 剛

  日本循環器学会学術集会抄録集, Mar. 2022

  
• Association Between Deleterious SCN5A Variants and Ventricular Septal Defect in Young Patients With Brugada Syndrome

  Keisuke Suzuki; Keiko Sonoda; Hisaaki Aoki; Yuko Nakamura; Seiichi Watanabe; Yoko Yoshida; Kenji Hoshino; Junichi Ozawa; Tomohiko Imamura; Takeshi Aiba; Koichi Kato; Takeru Makiyama; Kengo Kusano; Minoru Horie; Seiko Ohno

  JACC: Clinical Electrophysiology, Mar. 2022

  
• ヒトiPS細胞モデルを用いた遺伝性不整脈疾患の基礎研究 診断、発症機序解明、新規治療法開発

  牧山 武; 山本 雄大; 吉永 大介; 廣瀬 紗也子; 相澤 卓範; 柏 麻美; 高 景山; 今村 知彦; 黄 海; 糀谷 泰彦; 大野 聖子; 蒔田 直昌; 堀江 稔; 木村 剛

  循環器内科, Oct. 2021

  
• Cav1.2イオン選択性を障害するCACNA1C-E1115K変異患者由来iPS細胞心筋におけるlate Na電流阻害剤の効果に関する検討(Late Sodium Current Inhibitor Shortens Prolonged Action Potential Durations in iPS Cell-derived Cardiomyocytes of long QT syndrome associated with Cav 1.2 Ion Selectivity Disruption)

  Kashiwa Asami; Makiyama Takeru; Koujitani Hirohiko; Yamamoto Yuta; Gao Jingshan; Huang Hai; Imamura Tomohiko; Aizawa Takanori; Ishikawa Taisuke; Ono Seiko; Toyoda Futoshi; Sato Seiichi; Takahashi Kazuhiro; Horie Minoru; Kimura Takeshi

  The Journal of Physiological Sciences, Aug. 2021

  
• Diagnostic value of P-waves in children with idiopathic restrictive cardiomyopathy.

  Shota Muraji; Naokata Sumitomo; Tomohiko Imamura; Kazushi Yasuda; Eiki Nishihara; Mari Iwamoto; Shigetu Tateno; Shozaburo Doi; Tadayosi Hata; Shigetoyo Kogaki; Hitoshi Horigome; Seiko Ohno; Fukiko Ichida; Masami Nagashima; Masao Yoshinaga; Shintaro Nakano

  Heart and vessels, Aug. 2021

  
• Late recovery of the cardiopulmonary exercise capacity after transcatheter amplatzer device closures for atrial septal defects in adults

  Shigeki Yoshiba; Takuro Kojima; Takayuki Oyanagi; Koichi Toda; Yousuke Osada; Shota Muraji; Tomohiko Imamura; Shintaro Nakano; Shigeru Makita; Toshiki Kobayashi; Naokata Sumitomo

  Heart and Vessels, May 2021

  
• オリゴヌクレオチドを用いたcalmodulinopathyに対する治療法の開発(Development of an Oligonucleotide-Based Therapeutic Approach for Calmodulinopathy)

  Makiyama Takeru; Yamamoto Yuta; Kondoh Yoshiki; Gao Jingshan; Kashiwa Asami; Aizawa Takanori; Imamura Tomohiko; Huang Hai; Kohjitani Hirohiko; Ishikawa Taisuke; Yoshida Yoshinori; Ohno Seiko; Makita Naomasa; Horie Minoru; Kimura Takeshi

  日本循環器学会学術集会抄録集, Mar. 2021

  
• 遺伝性不整脈に対するオーダーメイド医療の現在の概観 iPS細胞を用いたリアノジン受容体遺伝子異常による遺伝性不整脈のモデリング(Current Perspective on Precision Medicine of Inherited Arrhythmias Modeling Inherited Arrhythmias Associated with Ryanodine Receptor Dysfunction Using iPS Cells)

  Makiyama Takeru; Gao Jingshan; Yamamoto Yuta; Kashiwa Asami; Aizawa Takanori; Imamura Tomohiko; Huang Hai; Kohjitani Hirohiko; Kato Kouichi; Ishikawa Taisuke; Aoki Hisaaki; Toyoda Futoshi; Wolten Knut; Yoshida Yoshinori; Ohno Seiko; Makita Naomasa; Kimura Takeshi

  日本循環器学会学術集会抄録集, Mar. 2021

  
• CRISPR/Cas9を用いたノックインゲノム編集技術で作製したiPS細胞モデルを用いたRYR2変異によるQT延長症候群のモデル化(Modeling RYR2-related Long-QT Syndrome Using iPS Cell Model Generated by CRISPR/Cas9-based Knock-in Genome Editing Technology)

  Gao Jingshan; Makiyama Takeru; Ohno Seiko; Yamamoto Yuta; Kashiwa Asami; Imamura Tomohiko; Aizawa Takanori; Huang Hai; Kohjitani Hirohiko; Kato Koichi; Toyoda Futoshi; Horie Minoru; Kimura Takeshi

  日本循環器学会学術集会抄録集, Mar. 2021

  
• 日本人レジストリに登録された小児ブルガダ症候群の臨床的特徴(Clinical Characteristics of Pediatric Brugada Syndrome in Japanese Registry)

  今村 知彦; 牧山 武; 小澤 淳一; 相澤 卓範; 柏 麻美; 山本 雄大; 糀谷 泰彦; 加藤 浩一; 青木 寿明; 大野 聖子; 鈴木 博; 住友 直方; 吉永 正夫; 堀江 稔; 木村 剛

  日本循環器学会学術集会抄録集, Mar. 2021

  
• Late recovery of the cardiopulmonary exercise capacity after transcatheter amplatzer device closures for atrial septal defects in adults.

  Yoshiba S; Kojima T; Oyanagi T; Toda K; Osada Y; Muraji S; Imamura T; Nakano S; Makita S; Kobayashi T; Naokata Sumitomo

  Heart and vessels, 02 Jan. 2021

  
• Impact of the T-wave characteristics on distinguishing arrhythmogenic right ventricular cardiomyopathy from healthy children.

  Tomohiko Imamura; Naokata Sumitomo; Shota Muraji; Kazushi Yasuda; Eiki Nishihara; Mari Iwamoto; Shigeru Tateno; Shozaburo Doi; Tadayoshi Hata; Shigetoyo Kogaki; Hitoshi Horigome; Seiko Ohno; Fukiko Ichida; Masami Nagashima; Takeru Makiyama; Masao Yoshinaga

  International journal of cardiology, 30 Aug. 2020, Peer-reviewed

  
• QT延長症候群に関連するCALM2-N98S変異はヒトiPSC由来心筋細胞におけるβ-アドレナリン刺激に対するKCNQ1チャネルの応答を損なう(CALM2-N98S Mutation Associated with Long QT Syndrome Impaired the Response of KCNQ1 Channel to Beta-adrenergic Stimulation in Human iPSC-derived Cardiomyocytes)

  Yamamoto Yuta; Makiyama Takeru; Wuriyanghai Yimin; Kohjitani Hirohiko; Hirose Sayako; Gao Jingshan; Kashiwa Asami; Huang Hai; Aizawa Takanori; Imamura Tomohiko; Ishikawa Taisuke; Yoshida Yoshinori; Ohno Seiko; Horie Minoru; Makita Naomasa; Kimura Takeshi

  日本循環器学会学術集会抄録集, Jul. 2020

  
• Usefulness of Combination of Mathematical Modeling and Cell Engineering Using Induced Pluripotent Stem Cells for Revealing Complex Disease Mechanism(和訳中)

  糀谷 泰彦; 柏 麻美; 野間 昭典; 牧山 武; 豊田 太; 山本 雄大; 烏日揚海 伊敏; 堀江 稔; 大野 聖子; 高 景山; 黄 海; 今村 知彦; 相澤 卓範; 静田 聡; 木村 剛

  日本循環器学会学術集会抄録集, Jul. 2020

  
• CALM2-N98S Mutation Associated with Long QT Syndrome Impaired the Response of KCNQ1 Channel to Beta-adrenergic Stimulation in Human iPSC-derived Cardiomyocytes(和訳中)

  Yamamoto Yuta; Makiyama Takeru; Wuriyanghai Yimin; Kohjitani Hirohiko; Hirose Sayako; Gao Jingshan; Kashiwa Asami; Huang Hai; Aizawa Takanori; Imamura Tomohiko; Ishikawa Taisuke; Yoshida Yoshinori; Ohno Seiko; Horie Minoru; Makita Naomasa; Kimura Takeshi

  日本循環器学会学術集会抄録集, Jul. 2020

  
• Human Induced Pluripotent Stem Cell Model of CACNA1C-E1115K which Impairs Ion Selectivity of the Cardiac L-type Calcium Channel(和訳中)

  柏 麻美; 牧山 武; Maurissen Thomas; 糀谷 泰彦; Wuriyanghai Yimin; 山本 雄大; Gao Jingshan; Huang Hai; 今村 知彦; 相澤 卓範; 石川 泰輔; 大野 聖子; 豊田 太; 佐藤 誠一; 高橋 一浩; Woltjen Knut; 堀江 稔; 蒔田 直昌; 木村 剛

  日本循環器学会学術集会抄録集, Jul. 2020

  
• 患者由来iPS細胞モデルを用いたCav 1.2イオン選択性を障害するCACNA1C-E1115K変異がQT延長症候群、Brugada症候群を発症するメカニズムの解析(CACNA1C-E1115K Mutation Associated with Overlap Phenotype of Long-QT and Brugada Syndrome Disrupts Cav 1.2 Ion Selectivity in Patient-specific iPS Cell-derived Cardiomyocytes)

  Kashiwa Asami; Makiyama Takeru; Kohjitani Hirohiko; Maurissen Thomas; Wuriyanghai Yimin; Yamamoto Yuta; Gao Jingshan; Huang Hai; Imamura Tomohiko; Aizawa Takanori; Ishikawa Taisuke; Ohno Seiko; Toyoda Futoshi; Sato Seiich; Takahashi Kazuhiro; Woltjen Knut; Horie Minoru; Makita Naomasa; Kimura Takeshi

  The Journal of Physiological Sciences, Mar. 2020

  
• Successful Ablation of Atrial Tachycardia Originating from Inside the Single Atrium and Conduit After a Fontan Operation.

  Hitoshi Mori; Naokata Sumitomo; Shota Muraji; Tomohiko Imamura; Noriyuki Iwashita; Toshiki Kobayashi

  International heart journal, 31 Jan. 2020, Peer-reviewed

  
• Improvement in Dyssynchrony with Pharmacological Ablation of Right-Sided Accessory Pathway-Induced Cardiomyopathy in Infants.

  Mai Sekine; Satoshi Masutani; Tomohiko Imamura; Yoichi Iwamoto; Shota Muraji; Shigeki Yoshiba; Hirotaka Ishido; Naokata Sumitomo

  International heart journal, 27 Sep. 2019, Peer-reviewed

  
• Anomalous origin of the coronary artery coursing between the great vessels presenting with a cardiovascular event (J-CONOMALY Registry).

  Nagashima K; Hiro T; Fukamachi D; Okumura Y; Watanabe I; Hirayama A; Tanaka M; Tanaka T; Takamisawa I; Taguchi I; Sato A; Aonuma K; Fukamizu S; Nakada A; Watanabe A; Amioka N; Suzuki Y; Matsumoto N; Koizumi J; Kumagai K; Naya M; Higuchi Y; Naito Y; Masuyama T; Kawamura M; Tsunoda R; Suzuki S; Ishii H; Murohara T; Shimizu T; Takeishi Y; Shiina K; Yamashita J; Imamura T; Sumitomo N; Noguchi T; Aso T; Furukawa K; Yamauchi Y; Okishige K; Sakata K; Yamagishi M; Shimizu S; Ohno M; Sugano T; Matsumura K; Matsumoto K; Ozaki K; Hayashidani S; Meno H; Iwata A; Higuma T; Tomita H; Yoshino H; Taniai S; Shishido K; Murakami M; Negishi K; Nii M; Wakatsuki D; Suzuki H; Motoike Y; Ozaki Y; Nakazato J; Hayashi H; Higuchi S; Shoda M

  European heart journal cardiovascular Imaging, Apr. 2019, Peer-reviewed

  
• Usefulness of Red Blood Cell Distribution Width in the Assessment of Hemodynamics After Tetralogy of Fallot Repair

  Tomohiko Imamura

  Circulation Journal, 25 Mar. 2019, Peer-reviewed

  
• Safety and accuracy of the Rhythmia mapping system in pediatric patients.

  Mori H; Muraji S; Sumitomo N; Kato R; Imamura T; Komori A; Iwashita N; Kobayashi T; Matsumoto K

  Heart rhythm, Mar. 2019, Peer-reviewed

  
• The necessity of implantable cardioverter defibrillators in patients with Kearns-Sayre syndrome - systematic review of the articles -

  Tomohiko Imamura

  International Journal of Cardiology, Mar. 2019, Peer-reviewed

  
• Efficacy of Wearable Cardioverter Defibrillators in 2 Children After Cardiopulmonary Arrest

  IMAMURA Tomohiko

  Japanese Journal of Electrocardiology, 2019, Peer-reviewed

  
• Efficacy of catheter interventions in the early and very early postoperative period after CHD operation

  Tomohiko Imamura

  Cardiology in the Young, Dec. 2018, Peer-reviewed

  
• Successful demonstration of the detailed connection between the twin atrioventricular nodes and sling in a patient with asplenia syndrome

  Tomohiko Imamura

  HeartRhythm Case Reports, Oct. 2018, Peer-reviewed

  
• Combination of flecainide and propranolol for congenital junctional ectopic tachycardia

  Tomohiko Imamura; Yuji Tanaka; Yumiko Ninomiya; Masao Yoshinaga

  PEDIATRICS INTERNATIONAL, Aug. 2015, Peer-reviewed

  

Misc.

• Development and Implementation of an Artificial Intelligence-Based Predictive Model for Sudden Cardiac Death by Integrating Personal Health Records and Clinical Data

  Tomohiko Imamura; Takashi Noda; Hisaki Makimoto; Satoshi Yoshimura; Tomonari Shimamoto; Norihiro Nishioka; Keitaro Senoo; Taku Iwami

  CIRCULATION, 24 Mar. 2026

  
• Rat model of cardiac laminopathy carrying Lmna-S143P mutation

  HAI Huang; 牧山武; 白井学; 若林真樹; 石川泰輔; 西内英; 森内健史; 高景山; 柏麻美; 今村知彦; 相澤卓範; 糀谷泰彦; 加藤浩一; 大野聖子; 中川靖章; 山内修; 桑原宏一郎; 蒔田直昌; 堀江稔; 木村剛

  日本心筋症研究会プログラム・抄録集(Web), 2023

  
• The AMED project titled ′′Research and Development on a Distributed PHR Data Exchange Infrastructure for Advanced Healthcare′′ focuses on the demonstration of PHR data distribution.

  島本大也; 西岡典弘; 今村知彦; 吉村聡志; 立山由紀子; 難波真人; 石見拓

  医療情報学連合大会論文集(CD-ROM), 2024

  
• Artificial Intelligence Based Optimization System for Cell-specific hiPSC-CMs Simulation and Prediction of Drug Testing

  KOHJITANI Hirohiko; MAKIYAMA Takeru; YAMAMOTO Yuta; YIMIN Wuriyanghai; YOSHINAGA Daisuke; KASHIWA Asami; IMAMURA Tomohiko; AIZAWA Takanori; GAO Jingshan; HUANG Hai; SHIZUTA Satoshi; KIMURA Takeshi

  日本循環器学会学術集会(Web), Jul. 2020

  
• 人工知能による細胞特異的hiPSC-CMsのシミュレーションと薬物試験予測の最適化手法(Artificial Intelligence Based Optimization System for Cell-specific hiPSC-CMs Simulation and Prediction of Drug Testing)

  Kohjitani Hirohiko; Makiyama Takeru; Yamamoto Yuta; Yimin Wuriyanghai; Yoshinaga Daisuke; Kashiwa Asami; Imamura Tomohiko; Aizawa Takanori; Gao Jingshan; Huang Hai; Shizuta Satoshi; Kimura Takeshi

  日本循環器学会学術集会抄録集, Jul. 2020

  
• Morphological and Electrophysiological Characterization of Homozygous Lamin A/C Knockout Human Induced-Pluripotent Stem Cell-Derived Cardiomyocytes

  Yimin Wuriyanghai; Takeru Makiyama; Yuta Yamamoto; Hirohiko Kohjitani; Sayako Hirose; Jingshan Gao; Asami Kashiwa; Hai Huang; Takanori Aizawa; Tomohiko Imamura; Seiko Ohno; Minoru Horie; Takeshi Kimura

  CIRCULATION, Nov. 2019

  
• KCNQ1 Channel Dysfunction in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Carrying a CALM2-N98S Mutation Associated With Long QT Syndrome

  Yuta Yamamoto; Takeru M. Makiyama; Yimin Wuriyanghai; Hirohiko Kohjitani; Sayako Hirose; Jingshan Gao; Asami Kashiwa; Huang Hai; Takanori Aizawa; Tomohiko Imamura; Taisuke Ishikawa; Seiko Ohno; Kazuhisa Chonabayashi; Hideki Motomura; Yoshinori Yoshida; Minoru Horie; Naomasa Makita; Takeshi Kimura

  CIRCULATION, Nov. 2019

  
• Patients characteristics of idiopathic ventricular fibrillation carrying SCN5A mutations without Brugada or long QT syndrome

  AIZAWA Takanori; MAKIYAMA Takeru; HUANG Hai; IMAMURA Tomohiko; GAO JingShan; KASHIWA Asami; YIMIN Wuriyanghai; KOHJITANI Hirohiko; YAMAMOTO Yuta; OHNO Seiko; HORIE Minoru

  Journal of Arrhythmia (Web), 2019

  

Presentations

• 心不全患者における Personal Health Record(PHR)データ登録率向上に向けた操作再説 明介入の効果検証

  齋藤知佳; 牧元久樹; 藤原健史; 福田詩織; 難波真人; 吉村聡志; 今村知彦; 興梠貴英; 石見拓; 苅尾七臣

  第23回日本循環器看護学会学術集会

  
• Treatment Strategies for Pediatric Brugada Syndrome: When and How to Intervene

  Tomohiko Imamura

  The 72nd JHRS Annual Scientific Meeting, 23 Jul. 2026, Invited

  
• Clinical Characteristics and Sex Difference in Pediatric Brugada Syndrome

  Tomohiko Imamura

  The 62nd Annual Meeting of Japanese Society of Pediatric Cardiology and Cardiac Surgery, 10 Jul. 2026, Invited

  
• 乳幼児突然死遺族の支援ニーズとプッシュ型支援体制の必要性

  今村知彦

  第129回日本小児科学会学術集会, 17 Apr. 2026

  
• Development and Implementation of an Artificial Intelligence-Based Predictive Model for Sudden Cardiac Death by Integrating Personal Health Records and Clinical Data

  Tomohiko Imamura

  American Heart Association EPI/Lifestyle 2026, 18 Mar. 2026

  
• The Path to Grief Care for Families Who Have Lost a Child ~Analysis of Access Routes~

  Tomohiko Imamura; Taku Iwami

  31th Japanese Society for the Prevention of Sudden Infant Death Academic Conference, 08 Feb. 2026

  
• Clinical Validation of Non-Contact Neonatal Vital Monitoring Using Millimeter-Wave Radar Technology

  Tomohiko Imamura; Tomoko Hisakado; Morio Sawada; Hiroshi Hatayama; Shigeaki Okumura; Hirofumi Taki; Takuya Sakamoto; Toru Sato; Koh Ono; Taku Iwami; Shin Watanabe

  31th Japanese Society for the Prevention of Sudden Infant Death Academic Conference, 08 Feb. 2026

  
• Current Status and Challenges in Handling Postmortem Examination Results: Perspectives of Families Who Lost Children to Unexpected Sudden Death

  Tomohiko Imamura

  31th Japanese Society for the Prevention of Sudden Infant Death Academic Conference, 07 Feb. 2026, Invited

  
• Development of Support System Using Generative AI for Emergency Data Registration

  Tomohiko Imamura

  Osaka Resuscitation Academy, 18 Dec. 2025, Invited

  
• Development of Support System Using Generative AI for Emergency Data Registration

  Tomohiko Imamura

  Kyoto Univ–Duke NUS International Resuscitation Science Symposium, 24 Nov. 2025, Invited

  
• The Views of Bereaved Families and Medical Professionals at the Scene of a Child's Death

  Tomohiko Imamura

  SIDS Family Association Befrienders Meeting, 14 Sep. 2025, Invited

  
• A Qualitative Study on Coping Behaviors and Potential Needs of Parents Who Lost a Child to Sudden Death

  Tomohiko Imamura

  JR West Japan Relief Foundation 15th (FY2024) Grant Program Results Presentation, 12 Sep. 2025, Invited

  
• Support needs in bereaved parents who lost a child by sudden unexpected death

  Tomohiko Imamura

  Pediatric Academic Society 2025 in Honolulu, 27 Apr. 2025

  
• Supporting the Grief of Families of Sudden Deaths: How medical professionals can help families who are facing confusion immediately after a sudden death occurs.

  Tomohiko Imamura

  30th Japanese Society for the Prevention of Sudden and Unexpected Death in Children, 09 Feb. 2025, Invited

  
• Cardiovascular-related diseases for which genetic testing should be recommended.

  Tomohiko Imamura

  70th Annual Meeting of the Japanese Heart Rhythm Society, 19 Jul. 2024, Invited

  
• Understanding Age-Related Differences in Electrocardiograms (Arrhythmogenic Right Ventricular Cardiomyopathy)

  今村知彦

  The 87th Annual Meeting of the Japanese Circulation Society, 11 Mar. 2023, Invited

  
• Clinical Characteristics and Risk Stratification in Pediatric Brugada Syndrome

  The 68th Annual Meeting of the Japanese Heart Rhythm Society, 10 Jun. 2022

  
• Effects of Age and Sex on Clinical and Electrocardiographic Features in Young Patients with Brugada Syndrome

  Heart Rhythm 2022 in SanFrancisco, 01 May 2022

  
• Clinical Aspects of Brugada Syndrome in Children: The Impact of Gender and Age on The Prognosis

  The 86th Annual Meeting of the Japanese Circulation Society, 03 Mar. 2022

  
• Investigation of Inherited Arrhythmias and Death Circumstances in Sudden Infant Death Syndrome Cases

  Tomohiko Imamura

  The 27th Annual Meeting of the Japan Society for SIDS and Sudden Infant Death Prevention, 20 Feb. 2022

  
• Clinical and Genetic Characteristics of Pediatric Brugada Syndrome: Influence of Age and Sex Hormones

  Tomohiko Imamura

  The 25th Annual Meeting of the Japanese Society of Pediatric Electrocardiology, 27 Nov. 2021, Invited

  
• Useful T-wave characteristics for screening in asymptomatic pediatric arrhythmogenic right ventricular cardiomyopathy

  Imamura Tomohiko

  67th Japanese Heart Rhythm Society, 01 Jul. 2021

  
• Cinical Characteristics of Pediatric Brugada syndrome in Japanese Registry

  Tomohiko Imamura

  85th Japanese Circulation Society, 28 Mar. 2021

  
• Clinical aspects of pediatric Brugada syndrome

  Tomohiko Imamura

  ESC congress 2020, 28 Aug. 2020

  
• The caracteristics of SCN5A genetic abnormalities for pediatric Brugada syndrome

  IMAMURA Tomohiko

  Japanese Society of Pediatric Cardiology and Cardiac Surgery, 27 Jun. 2019

  
• Clinical and Electrocardiographic Features of Arrhythmogenic Right Ventricular Cardiomyopathy in Children

  IMAMURA Tomohiko

  European Heart Rhythm Association 2019, 17 Mar. 2019

  
• Recurrence of Verapamil-Sensitive Ventricular Tachycardia in Children

  Tomohiko Imamura

  The 30th Annual Meeting of the Japanese Society for Pediatric Interventional Cardiology, 24 Jan. 2019

  
• Efficacy and Safety of Catheter Ablation for Pediatric Ventricular Arrhythmias Originating in the Sinus of Valsalva

  Tomohiko Imamura

  Japanese Society of Pediatric Electrocardiology Annual Meeting, 01 Dec. 2018

  
• Recurrence of Verapamil-Sensitive Ventricular Tachycardia in Children

  今村 知彦

  Japanese Autumn Conference on Catheter Ablation, 09 Nov. 2018

  
• Experience introducing WCD to 2 children with cardiopulmonary arrest resuscitation.

  The 65th Annual Meeting of the Japanese Heart Rhythm Society, 14 Jul. 2018

  
• Association Between Keans-Sayre Syndrome and Fatal Arrhythmias: The Need for Implantable Cardioverter Defibrillators

  Tomohiko Imamura

  The 54th Annual Meeting of the Japanese Society for Pediatric Cardiology, 05 Jul. 2018

  
• Fatal arrhythmia in Kearns-Sayre syndrome: Necessity of implantable cardioverter defibrillator

  IMAMURA Tomohiko

  Japanese Society of Pediatric Cardiology and Cardiac Surgery, 05 Jul. 2018

  
• Characteristics of pediatric Brugada syndrome.

  The annual congress of the European Heart Rhythm Association 2018, 18 Mar. 2018

  
• Indications and Issues for Wearable Automated External Defibrillators in Children

  10th Japanese Winter Conference on Implantable Devices, 12 Feb. 2018

  
• Factors Associated with Recurrence Risk After Cryoablation for Pediatric AVNRT

  The 29th Annual Meeting of the Japanese Society for Pediatric Interventional Cardiology, 18 Jan. 2018

  
• A Pediatric Case Diagnosed with Left Coronary Artery Without Arterial Origin Following Two Cardiac Arrest Resuscitations

  The 30th Conference on Sudden Cardiac Death, 16 Dec. 2017

  
• A Case of ATP-Sensitive Atrial Tachycardia Following Intracardiac Repair of Tetralogy of Fallot

  The 22nd Annual Meeting of the Japanese Society of Pediatric Electrocardiology, 25 Nov. 2017

  
• A Case of Kearns-Sayre Syndrome with QT Prolongation and Torsades de Pointes

  The 30th Kyushu Pediatric Arrhythmia Study Group, 11 Nov. 2017

  

Books and Other Publications

• School Heart Screening Practice Manual Q&A

  Tomohiko Imamura, Joint work, Management of Brugada Syndrome in School-Age Children

  診断と治療社, Mar. 2026

  
• Pediatric Practice: Essential Tips for Resident Physicians on ECG Interpretation

  Joint work, Ⅲ.不整脈. 房室ブロック

  診断と治療社, May 2020

  
• Management and education for daily life in infants and children with heart disease.,

  Jan. 2019, Not refereed

  

Awards

• 29 Jun. 2013

  研修医最優秀演題賞（日本循環器学会九州地方会）
• 01 Jul. 2021

  ＹＩＡ優秀演題賞（日本不整脈心電学会）

Education

Teaching subject(s)

• From 01 Apr. 2026, To 31 Mar. 2027

  Implementation Research in Health and Preventive Medicine

  M421, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Clinical research advanced

  K034, Fall, Graduate School of Medicine, 2
• From 01 Apr. 2026, To 31 Mar. 2027

  Implementation Research in Health and Preventive Medicine

  H171, Fall, Graduate School of Medicine, 2

Academic, Social Contribution

Committee Memberships

• 診断基準検討委員会委員, 日本小児突然死予防医学会
• From May 2025, To Present

  Committee for the Revision of the 3rd Edition of the SIDS Diagnostic Guidelines, Japanese Society for the Prevention of Sudden and Unexpected Death in Children
• From Apr. 2025, To Present

  Crossover Research Committee Member, Department of Social and Preventive Medicine, Graduate School of Medicine, Kyoto University, 京都大学大学院医学研究科社会健康医学系専攻
• From Apr. 2025, To Present

  Academic Affairs Committee Member, Department of Social and Preventive Medicine, Graduate School of Medicine, Kyoto University, 京都大学大学院医学研究科社会健康医学系専攻
• From Jan. 2024, To Present

  Collaborator, Working Group for the 2026 Revised Guidelines for the Diagnosis and Treatment of Inherited Arrhythmias, Japanese Circulation Society, 日本循環器学会
• From Sep. 2023, To Dec. 2024

  Collaborator, Statement Development Team for Sudden Cardiac Death Prevention, Emergency Awareness Subcommittee, Japanese Circulation Society, 日本循環器学会

Academic Contribution

• Kyoto University–Duke NUS International Resuscitation Symposium

  Planning, management, etc., Panel moderator

  From 24 Nov. 2025, To 26 Nov. 2025

  
• Differential Diagnosis of Brugada Syndrome and Acute Pericarditis Presenting as Brugada Phenocopy

  Peer review

  From 01 Apr. 2025

  

Social Contribution

• Little Lives: Grief Care Exchange Workshop

  Lecturer

  Little Lives: Society of Bereaved Families, From 02 Aug. 2026

  
• Sudden Child Death and Grief Support in Japan: From Epidemiology to Prevention and Family Support

  Lecturer

  Andalas University in Indonesia, Out-of-Hospital Cardiac Arrest: A race against the clock and current concept, From 31 Jan. 2026, To 31 Jan. 2026

  
• Osaka Resuscitation Aademy

  Logistic support

  From 01 Apr. 2025, To Present