Basic Information

Professional Memberships

• 日本免疫学会
• 日本分子生物学会

Academic Degree

• 修士（農学）(広島大学)
• 博士（農学）(広島大学)

Research History

• From Apr. 2018, To Present

  京都大学 医学研究科, 特定助教
• From Apr. 2011, To Mar. 2017

  京都大学 医学研究科, 研究員
• From Apr. 2010, To Mar. 2011

  広島大学 生物圏科学研究科, 特任助教

ID,URL

• J-Global ID

  201401003434622058

researchmap URL

• https://researchmap.jp/7000010589

Research

Research Topics, Overview of the research

• Research Topics

  Cellular and molecular mechanisms of immunosenescence that underlie the pathogenesis of age-related diseases.

• Overview of the research

  Immunosenescence underlies the pathogenesis of age-related diseases, but the mechanism is not fully understood. We aim to understand the cellular and molecular mechanisms of T-cell aging (with a particular focus on senescence-associated T cells) that play a key role in immunesenescence and develop the effective means to prevent autoimmune diseases, neural disorders, and cancer.

Research Interests

• 免疫老化
• 自己免疫
• がん
• 中枢神経

Research Areas

• Life sciences, Immunology
• Life sciences, Neuropathology
• Life sciences, Tumor biology

Papers

• Senescence-Associated T cells in Immunosenescence and Diseases.

  Yuji Fukushima; Ryuji Ueno; Nagahiro Minato; Masakazu Hattori

  International immunology, 25 Sep. 2024, Peer-reviewed, Invited, Corresponding author

  
• Protocol for the isolation of mouse senescence-associated CD4+ T cells using flow cytometry and functional assays.

  Yuji Fukushima; Nagahiro Minato; Masakazu Hattori

  STAR protocols, 28 Jul. 2023, Peer-reviewed, Invited, Corresponding author

  Access this paper :

  
• cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells.

  Yuji Fukushima; Keiko Sakamoto; Michiyuki Matsuda; Yasunobu Yoshikai; Hideo Yagita; Daisuke Kitamura; Misaki Chihara; Nagahiro Minato; Masakazu Hattori

  Cell reports, 20 Sep. 2022, Peer-reviewed, Corresponding author

  Access this paper :

  
• CD153/CD30 signaling promotes age-dependent tertiary lymphoid tissue expansion and kidney injury.

  Yuki Sato; Akiko Oguchi; Yuji Fukushima; Kyoko Masuda; Naoya Toriu; Keisuke Taniguchi; Takahisa Yoshikawa; Xiaotong Cui; Makiko Kondo; Takeshi Hosoi; Shota Komidori; Yoko Shimizu; Harumi Fujita; Li Jiang; Yingyi Kong; Takashi Yamanashi; Jun Seita; Takuya Yamamoto; Shinya Toyokuni; Yoko Hamazaki; Masakazu Hattori; Yasunobu Yoshikai; Peter Boor; Jürgen Floege; Hiroshi Kawamoto; Yasuhiro Murakawa; Nagahiro Minato; Motoko Yanagita

  The Journal of clinical investigation, 18 Jan. 2022, Peer-reviewed

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• The impact of senescence-associated T cells on immunosenescence and age-related disorders

  Fukushima Y; Minato N; Hattori M

  Inflammation and regeneration, 2018, Peer-reviewed, Invited

  
• The potential role of Osteopontin in the maintenance of commensal bacteria homeostasis in the intestine.

  Koyu Ito; Akira Nakajima; Yuji Fukushima; Keiichiro Suzuki; Keiko Sakamoto; Yoko Hamazaki; Kouetsu Ogasawara; Nagahiro Minato; Masakazu Hattori

  PloS one, 2017, Peer-reviewed

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• Osteopontin in Spontaneous Germinal Centers Inhibits Apoptotic Cell Engulfment and Promotes Anti-Nuclear Antibody Production in Lupus-Prone Mice.

  Keiko Sakamoto; Yuji Fukushima; Koyu Ito; Michiyuki Matsuda; Shigekazu Nagata; Nagahiro Minato; Masakazu Hattori

  Journal of immunology (Baltimore, Md. : 1950), 15 Sep. 2016, Peer-reviewed

  
• A CD153(+)CD4(+) T Follicular Cell Population with Cell-Senescence Features Plays a Crucial Role in Lupus Pathogenesis via Osteopontin Production

  Suhail Tahir; Yuji Fukushima; Keiko Sakamoto; Kyosuke Sato; Harumi Fujita; Joe Inoue; Toshimitsu Uede; Yoko Hamazaki; Masakazu Hattori; Nagahiro Minato

  JOURNAL OF IMMUNOLOGY, Jun. 2015, Peer-reviewed

  
• Molecular cloning of chicken interleukin-5 receptor alpha-chain and analysis of its binding specificity

  Yuji Fukushima; Tomohiro Miyai; Manami Kumagae; Hiroyuki Horiuchi; Shuichi Furusawa

  DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, Jul. 2012, Peer-reviewed

  
• Construction of an Insertion Vector for Gene Targeting of Chicken Lens-specific Gene

  Yuji Fukushima; Masaharu Sato; Haruo Matsuda; Shuichi Furusawa; Hiroyuki Horiuchi

  JOURNAL OF POULTRY SCIENCE, Apr. 2010, Peer-reviewed

  
• Induction of Immune Suppression in the Chick by an Optimal Dose of an Immunizing Antigen in the Presence of its Specific Maternal Antibody

  Mohamed Fahmy Abou Elazab; Yuji Fukushima; Yukihiro Fujita; Hiroyuki Horiuchi; Haruo Matsuda; Shuichi Furusawa

  JOURNAL OF VETERINARY MEDICAL SCIENCE, Mar. 2010, Peer-reviewed

  
• Prolonged Suppression of Chick Humoral Immune Response by Antigen Specific Maternal Antibody

  Mohamed Fahmy Abou Elazab; Yuji Fukushima; Hiroyuki Horiuchi; Haruo Matsuda; Shuichi Furusawa

  JOURNAL OF VETERINARY MEDICAL SCIENCE, Apr. 2009, Peer-reviewed

  
• Cloning of the chicken interleukin-13 receptor alpha 2 gene and production of a specific monoclonal antibody

  Miki Miyoshi; Hiroyuki Horiuchi; Yuji Fukushima; Haruo Matsuda; Shuichi Furusawaa

  DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY, 2007, Peer-reviewed

  

Misc.

• 老化関連T細胞と慢性炎症および自己免疫疾患

  福島 祐二; 湊 長博; 服部 雅一

  実験医学, Jan. 2025

  
• T細胞の加齢変化と老化関連T細胞の病理学的関与

  福島 祐二; 服部 雅一

  臨床免疫・アレルギー科, Jan. 2023

  

Presentations

• 免疫老化の基盤にあるT細胞の制御と疾患抑制

  福島 祐二

  共創の場形成支援プログラム 若手人材育成セミナー, 21 Oct. 2024

  
• Senescence-associated CD4+ T cells and Autoimmune Pathology

  Yuji Fukushima

  The 52nd Annual Meeting of The Japanese Society for Immunology, International Symposium, DGFI-JSI Joint Session, Jan. 2024, Invited

  
• 老化関連T細胞と自己免疫疾患

  福島 祐二

  第５１回 日本臨床免疫学会総会 シンポジウム, Oct. 2023, Invited

  
• CD153-CD30 interaction is involved in immunosenescence of T cells and spontaneous germinal center reactions

  Fukushima Y; Yamada H; Yoshikai Y; Minato N; Hattori M

  第４５回 日本免疫学会学術集会, Dec. 2016

  

External funds: Kakenhi

• 加齢変容性リンパ球が介在する多発性硬化症の病態機序解明とその制御

  Grant-in-Aid for Scientific Research (B)

  Basic Section 51030:Pathophysiologic neuroscience-related

  Kyoto University

  福島 祐二

  From 01 Apr. 2024, To 31 Mar. 2028, Granted

  加齢変容性リンパ球;多発性硬化症;CAR-T細胞;in vivoイメージング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02351/
• 非定型TCR複合体を形成する機能不全耐性T細胞集団の作出とがん治療への応用

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 50:Oncology and related fields

  Kyoto University

  福島 祐二

  From 30 Jun. 2022, To 31 Mar. 2025, Granted

  T細胞機能不全;非定型TCR;活性制御;がん

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19455/
• Study on a new ajuvant that induce memory T cells efficiently

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 42:Veterinary medical science, animal science, and related fields

  Kyoto University

  Masakazu Hattori

  From 29 Jun. 2018, To 31 Mar. 2020, Project Closed

  CD153;メモリーT細胞;CD3複合体;免疫チェックポイント分子;免疫老化;老化関連T細胞;CD153リバースシグナル;アジュバント;CD30L;CD30

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19268/
• Control of senescence-associated T cell-induction

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Masakazu Hattori

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  免疫老化;老化関連T細胞;CD153;CD3複合体;リバースシグナル;加齢関連疾患;オステオポンチン;CD153リバースシグナル;TCRシグナル抑制;T細胞;自己抗体;CD163-CD30相互作用;TCRシグナル阻害;免疫学;老化;自己免疫疾患;SLE

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H03925/
• Study on the mechanism(s) of immunosenescence and its application for vaccine development.

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Masakazu HATTORI

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  免疫老化;T細胞;PD-1;CD153;オステオポンチン;全身性エリテマトーデス;死細胞処理;貪食;自己免疫疾患;自己抗体;老化関連T細胞;胚中心;miR181a

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26450443/

External funds: others

• 免疫老化関連分子を活用した免疫監視機構の人為的強化

  武田科学振興財団, 医学系研究助成

  From 2022

  福島 祐二