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Ohtsuki, Gen
Graduate School of Medicine, Medicine Program-Specific Professor
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Last Updated :2025/05/02
Basic Information
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Academic Degree
High School
High School
兵庫県立神戸高等学校（理数コース）
Research History
- From Apr. 2020, To PresentKyoto University, Graduate School of Medicine, Department of Drug Discovery Medicine, Program-specific Professor
- From Apr. 2015, To Mar. 2020Kyoto University, The Hakubi Center for Advanced Research, Program-specific Associate Professor
- From Apr. 2011, To Mar. 2015Kyushu University, Graduate School of Medical Sciences, Specially Appointed Assistant Professor
- From Jul. 2008, To Mar. 2011The University of Chicago, Department of Neurobiology, Postdoctoral Scholar
- From Apr. 2007, To Jul. 2008Erasmus University Medical Center（Netherlands）, Postdoctoral Fellow
- From Apr. 2006, To Mar. 2008JSPS Research Fellowships for Young Scientists
Profile
Profile
これまで、京都大学大学院医学研究科 創薬医学講座（メディカルイノベーションセンター）の特定教授として、脳の炎症と精神疾患発症機序の究明を目指し、げっ歯類とヒトでの精神障害の回復を目指す研究を行ってきました。
研究手法は、電気生理学的手法（多細胞パッチクランプ、樹状突起記録、シナプス伝達解析、興奮性可塑性解析、膜興奮性解析、長期可塑性など、脳切片下の記録）と in vivo 電気生理学記録、イメージング（共焦点顕微鏡、二光子顕微鏡、超解像顕微鏡、、小動物核磁気画像法（fMRI））、ミクログリア細胞解析、げっ歯類での行動実験、光・薬理遺伝学的操作、大規模データ解析（細胞レベルイメージングデータ、深層学習、生成AI、ヒトコホートデータ解析、超多重抗体染色、RNA空間解析など）、細胞レベル数理モデルシミュレーションなど。現在はマルチオミクスと細胞種特異的遺伝子改変を用いた精神疾患と神経変性疾患の解析および治療法開発を目指しています。
尊敬する多くの先生方の背中を見て、日々チームの皆で研究開発に精励しております。
変わらぬご指導ご鞭撻のほど戴けましたら、幸甚にございます。
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Last Updated :2025/05/02
Research
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Papers
- Maternal immune activation followed by peripubertal stress combinedly produce reactive microglia and confine cerebellar cognitionMomoka Hikosaka; Md Sorwer Alam Parvez; Yuki Yamawaki; Souichi Oe; Yuan Liang; Yayoi Wada; Yukie Hirahara; Taro Koike; Hirohiko Imai; Naoya Oishi; Sina M. Schalbetter; Asuka Kumagai; Mari Yoshida; Takeshi Sakurai; Masaaki Kitada; Urs Meyer; Shuh Narumiya; Gen OhtsukiCommunications Biology, 03 Mar. 2025, Peer-reviewed, Last author, Corresponding author
- Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neuronsAyako Kawatake-Kuno; Haiyan Li; Hiromichi Inaba; Momoka Hikosaka; Erina Ishimori; Takatoshi Ueki; Yury Garkun; Hirofumi Morishita; Shuh Narumiya; Naoya Oishi; Gen Ohtsuki; Toshiya Murai; Shusaku UchidaNeuron, Feb. 2024, Peer-reviewed, Corresponding author
- Editorial: Cerebellum-related learning and psychiatric diseases.Gen Ohtsuki; Taegon Kim; Peng Sun; Yongjun Chen; Egidio Ugo D'AngeloFrontiers in cellular neuroscience, 2023, Peer-reviewed, Invited, Lead author, Corresponding author
- Insights from a computational analysis of the SARS-CoV-2 Omicron variant: Host-pathogen interaction, pathogenicity, and possible drug therapeutics.Md Sorwer Alam Parvez; Manash Kumar Saha; Md Ibrahim; Yusha Araf; Md Taufiqul Islam; Gen Ohtsuki; Mohammad Jakir HosenImmunity, inflammation and disease, Jul. 2022, Corresponding author
- Acute Cerebellar Inflammation and Related Ataxia: Mechanisms and Pathophysiology.Md Sorwer Alam Parvez; Gen OhtsukiBrain sciences, 10 Mar. 2022, Peer-reviewed, Invited, Last author, Corresponding author
- Microglia-triggered hypoexcitability plasticity of pyramidal neurons in the rat medial prefrontal cortexYuki Yamawaki; Yayoi Wada; Sae Matsui; Gen OhtsukiCurrent Research in Neurobiology, Feb. 2022, Peer-reviewed, Invited, Last author, Corresponding author
- High permeability of the CSF flow in the juvenile mouse brain by brain-wide DCE-MRIYayoi Wada; Hirohiko Imai; Yuki Yamawaki; Md Sorwer Alam Parvez; Sae Matsui; Gen Ohtsuki24 Sep. 2021
- Psychosis symptoms following aberrant immunity in the brain.Akitoshi Ozaki; Yuki Yamawaki; Gen OhtsukiNeural regeneration research, Mar. 2021, Peer-reviewed, Invited, Last author, Corresponding author
- Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar InflammationYamamoto, M.; Kim, M.; Imai, H.; Itakura, Y.; Ohtsuki, G.Cell Reports, 10 Sep. 2019, Peer-reviewed, Last author, Corresponding author
- Microglia-triggered hyperexcitability in the cerebellum depresses animal behaviorsYamamoto M; Kim M; Imai H; Ohtsuki GbioRxiv, Jun. 2018
- Synaptic Potential and Plasticity of an SK2 Channel Gate Regulate Spike Burst Activity in Cerebellar Purkinje CellsOhtsuki, G.; Hansel, C.iScience, Mar. 2018, Peer-reviewed, Lead author
- Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje CellsGrasselli, G.; He, Q.; Wan, V.; Adelman, J.P.; Ohtsuki, G.; Hansel, C.Cell Reports, Mar. 2016, Peer-reviewed
- The Spontaneous Ataxic Mouse Mutant Tippy is Characterized by a Novel Purkinje Cell Morphogenesis and Degeneration PhenotypeShih, E.K.; Sekerková, G.; Ohtsuki, G.; Aldinger, K.A.; Chizhikov, V.V.; Hansel, C.; Mugnaini, E.; Millen, K.J.Cerebellum, Jun. 2015, Peer-reviewed
- Similarity of visual selectivity among clonally related neurons in visual cortexOhtsuki, G.; Nishiyama, M.; Yoshida, T.; Murakami, T.; Histed, M.; Lois, C.; Ohki, K.Neuron, Jul. 2012, Peer-reviewed
- SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cellsOhtsuki, G.; Piochon, C.; Adelman, J.P.; Hansel, C.Neuron, Jul. 2012, Peer-reviewed
- Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cellsBelmeguenai, A.; Hosy, E.; Bengtsson, F.; Pedroarena, C.M.; Piochon, C.; Teuling, E.; He, Q.; Ohtsuki, G.; De Jeu, M.T.G.; Elgersma, Y.; De Zeeuw, C.I.; Jörntell, H.; Hansel, C.Journal of Neuroscience, Oct. 2010, Peer-reviewed
- Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learningSchonewille, M.; Belmeguenai, A.; Koekkoek, S.K.; Houtman, S.H.; Boele, H.J.; van Beugen, B.J.; Gao, Z.; Badura, A.; Ohtsuki, G.; Amerika, W.E.; Hosy, E.; Hoebeek, F.E.; Elgersma, Y.; Hansel, C.; De Zeeuw, C.I.Neuron, Aug. 2010, Peer-reviewed
- Purkinje cell NMDA receptors assume a key role in synaptic gain control in the mature cerebellumPiochon, C.; Levenes, C.; Ohtsuki, G.; Hansel, C.Journal of Neuroscience, 2010, Peer-reviewed
- Climbing fiber signaling and cerebellar gain controlGen Ohtsuki; Claire Piochon; Christian HanselFRONTIERS IN CELLULAR NEUROSCIENCE, Jul. 2009, Peer-reviewed
- Bidirectional plasticity at developing climbing fiber-Purkinje neuron synapsesGen Ohtsuki; Tomoo HiranoEUROPEAN JOURNAL OF NEUROSCIENCE, Dec. 2008, Peer-reviewed
- Enhancement of Both Long-Term Depression Induction and Optokinetic Response Adaptation in Mice Lacking DelphilinTomonori Takeuchi; Gen Ohtsuki; Takashi Yoshida; Masahiro Fukaya; Tasuku Wainai; Manami Yamashita; Yoshito Yamazaki; Hisashi Mori; Kenji Sakimura; Susumu Kawamoto; Masahiko Watanabe; Tomoo Hirano; Masayoshi MishinaPLOS ONE, May 2008, Peer-reviewed
- Threshold regulation of cerebellar LTD is critical for motor learning efficiencyTomonori Takeuchi; Gen Ohtsuki; Takashi Yoshida; Masahiro Fukaya; Tasuku Wainai; Hisashi Mori; Kenji Sakimura; Susumu Kawamoto; Masahiko Watanabe; Tomoo Hirano; Masayoshi MishinaNEUROSCIENCE RESEARCH, 2006, Peer-reviewed
- Enhanced inhibitory synaptic transmission in the cerebellar molecular layer of the GluR delta 2 knock-out mouseG Ohtsuki; S Kawaguchi; M Mishina; T HiranoJOURNAL OF NEUROSCIENCE, Dec. 2004, Peer-reviewed
- Oscillating Purkinje neuron activity causing involuntary eye movement in a mutant mouse deficient in the glutamate receptor delta 2 subunitT Yoshida; A Katoh; G Ohtsuki; M Mishina; T HiranoJOURNAL OF NEUROSCIENCE, Mar. 2004, Peer-reviewed
Misc.
- Threshold regulation of LTD at PF-PC synapses is crucial for the efficiency of OKR gain-increase adaptationTomonori Takeuchi; Gen Ohtsuki; Takashi Yoshida; Masahiro Fukaya; Masahiko Watanabe; Tomoo Hitano; Masayoshi MishinaJOURNAL OF PHARMACOLOGICAL SCIENCES, 2007
- Facilitated cerebellar LTD and OKR adaptation in mice lacking DelphilinT Takeuchi; T Yoshida; G Ohtsuki; T Hirano; T Wainai; M Fukaya; M Watanabe; H Mori; K Sakimura; S Kawamoto; M MishinaJOURNAL OF PHARMACOLOGICAL SCIENCES, 2006
Presentations
- Immune-triggered excitability plasticity and psychiatric disease modelsOhtsuki GThe 25th Annual Meeting of the Korean Society for Brain and Neural Sciences (Incheon, Korea), Invited
- Plasticity of the intrinsic excitability in the acute inflammation and psychiatric diseaseOhtsuki GThe 99th Annual Meeting of the Physiological Society of Japan (Sendai, Japan)
- Intrinsic plasticity of the Purkinje-cell dendrites and immune stressOhtsuki G1st China-Japan-Korea International Meeting and 44th Annual Meeting of the Japan Neuroscience Society (Kobe, Japan), Invited
- Excitability plasticity and mental depressiveness during acute inflammation in the cerebellum大槻 元生理学研究所研究会 「ミクロからマクロに至る脳の構造と機能のダイナミクス」, 07 Nov. 2019
- Aberrant Immunity in the Cerebellum Modulates Our MoodGen OhtsukiNeuroscience2019 in SfN - Press Conferrence, 21 Oct. 2019, Society for Neuroscience, Invited
- Excitability plasticity and mental depressiveness during acute inflammation in the cerebellumGen OhtsukiWMU-IFAR, Wenzhou Medical University Institute for Advanced Research, 15 Sep. 2019, Jian Yang and Zi-Bing JIN, Invited
- Functional Diversification in Clonal Cells after Eye-Opening in Mouse Visual CortexGen Ohtsuki京都大学大学院 理学研究科 ミニシンポジウム, Jul. 2015, 田川義晃
- Functional organization of clonally related neurons in mouse visual cortex during developmentOhtsuki G; Nishiyama M; Yoshida T; Murakami T; Histed M; Lois C; Ohki K日本神経科学学会, Jul. 2013, 日本神経科学学会
- Activity-dependent control of signaling gains in neuronal dendritesGen OhtsukiGordon Research Seminar Dendrites: Molecules, Structure & Function, 12 Mar. 2011, Georgeann S. Sack and Denise Cook
- Long-term plasticity at cerebellar climbing fiber-Purkinje cell synapsesGen OhtsukiLong-term plasticity at cerebellar climbing fiber-Purkinje cell synapses, 2010, ノースウエスタン大学 医学部, Invited
Books and Other Publications
- 生体の科学 Vol.72 No.1 [特集]小脳研究の未来 プルキンエ細胞興奮性の可塑性大槻 元; 山脇優輝; 谷垣宏亮, Joint work医学書院, Feb. 2021
- Modulation of the neural function based on the plasticity of intrinsic excitability in the cerebellumGen Ohtsuki, Contributor, Neurophysiology(公財)ブレインサイエンス振興財団, Jun. 2019, Not refereed
External funds: Kakenhi
- Dimensional approaches to psychiatric disorders associated with circuit abnormalities induced by genetic and environmental insults combined with inflammation in the brainGrant-in-Aid for Scientific Research (B)Basic Section 51030:Pathophysiologic neuroscience-relatedKyoto UniversityTakeshi SakuraiFrom 01 Apr. 2019, To 31 Mar. 2022, Project Closed社会性ストレス;思春期;マウスモデル;脳内炎症;精神疾患
- Analysis of the functional development of clonally-related neurons in the visual cortexGrant-in-Aid for Young Scientists (A)Kyoto University;Kyushu UniversityGen OhtsukiFrom 01 Apr. 2014, To 31 Mar. 2018, Project Closedクローン細胞;遺伝子改変マウス;大脳皮質;一次視覚野;生体下Ca2+イメージング;細胞位置機能解析;機能発達;３次元位置機能解析;大脳皮質一次視覚野;多細胞同時パッチクランプ;3次元位置機能解析;4細胞同時パッチクランプ記録
- 複合炎症精神疾患モデルマウスの小脳機能低下の神経生理学的機序解明Grant-in-Aid for Scientific Research (C)Basic Section 46010:Neuroscience-general-relatedKyoto University大槻 元From 01 Apr. 2023, To 31 Mar. 2026, Granted複合炎症ストレス;精神疾患;シナプス可塑性;免疫誘導型可塑性;小脳
