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Ohtsuki, Gen

Graduate School of Medicine Program-Specific Professor

Ohtsuki, Gen
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    Last Updated :2024/02/21

    Basic Information

    Professional Memberships

    • Society for Neuroscience, USA
    • THE PHYSIOLOGICAL SOCIETY OF JAPAN
    • THE JAPAN NEUROSCIENCE SOCIETY

    Academic Degree

    • Master of Science, Neurobiology(Kyoto University)
    • Ph.D., Neurobiology(Kyoto University)

    High School

    • High School

      兵庫県立神戸高等学校(理数コース)

    Research History

    • From Apr. 2020, To Present
      Kyoto University, Graduate School of Medicine, Department of Drug Discovery Medicine, Program-specific Professor
    • From Apr. 2015, To Mar. 2020
      Kyoto University, The Hakubi Center for Advanced Research, Program-specific Associate Professor
    • From Apr. 2011, To Mar. 2015
      Kyushu University, Graduate School of Medical Sciences, Specially Appointed Assistant Professor
    • From Jul. 2008, To Mar. 2011
      The University of Chicago, Department of Neurobiology, Postdoctoral Scholar
    • From Apr. 2007, To Jul. 2008
      Erasmus University Medical Center(Netherlands), Postdoctoral Fellow
    • From Apr. 2006, To Mar. 2008
      JSPS Research Fellowships for Young Scientists

    Profile

    • Profile

      これまで京都大学白眉センター にて特定准教授として、脳生理学的機能に関する独立研究を行って参りました。2020年4月1日から、京都大学大学院医学研究科 創薬医学講座の特定教授に着任しました。脳の炎症と精神疾患発症機序の究明を目指し、ヒト・霊長類での精神障害の回復を目指す研究を行います。ひき続き、ご支援ご鞭撻のほど戴けましたら、幸甚にございます。

      研究手法は、電気生理学的手法(多細胞パッチクランプ、樹状突起記録、シナプス伝達解析、興奮性可塑性解析、膜興奮性解析、長期可塑性など、脳切片下の記録では迅速なデータ取得が可能です)、イメージング(共焦点顕微鏡を使ったスパインイメージング、二光子顕微鏡を使った生体下神経・グリア活動観察)、げっ歯類での行動実験、光・薬理遺伝学的操作、小動物核磁気画像法(fMRI)解析、大規模データ解析(細胞レベルイメージングデータ、電気生理学的複数同時細胞記録による多シナプス電流解析など)、神経細胞レベルのコンピュータシミュレーションなど。小脳を対象とした可塑性研究領域全般に強みがございます。

    Language of Instruction

    • Japanese
    • English

    ID,URL

    Website(s) (URL(s))

    researchmap URL

    list
      Last Updated :2024/02/21

      Research

      Research Areas

      • Life sciences, Neuroscience - general

      Papers

      • Environmental stress insults in 2HIT model synergistically produce disorder-associated microglia and macrophages in the cerebellum
        Yuki Yamawaki; Md Sorwer Alam Parvez; Yayoi Wada; Souichi Oe; Yukie Hirahara; Taro Koike; Momoka Hikosaka; Asuka Kumagai; Sae Matsui; Takeshi Sakurai; Masaaki Kitada; Shuh Narumiya; Gen Ohtsuki
        Research Square (preprint), 21 Feb. 2023, Last author, Corresponding author
      • Editorial: Cerebellum-related learning and psychiatric diseases.
        Gen Ohtsuki; Taegon Kim; Peng Sun; Yongjun Chen; Egidio Ugo D'Angelo
        Frontiers in cellular neuroscience, 2023, Peer-reviewed, Invited, Lead author, Corresponding author
      • Immune-triggered forms of plasticity across brain regions
        Momoka Hikosaka; Takeo Kawano; Yayoi Wada; Tomoki Maeda; Takeshi Sakurai; Gen Ohtsuki
        Frontiers in Cellular Neuroscience, Jun. 2022, Peer-reviewed, Last author, Corresponding author
      • Insights from a computational analysis of the SARS-CoV-2 Omicron variant: Host-pathogen interaction, pathogenicity, and possible drug therapeutics.
        Md Sorwer Alam Parvez; Manash Kumar Saha; Md Ibrahim; Yusha Araf; Md Taufiqul Islam; Gen Ohtsuki; Mohammad Jakir Hosen
        Immunity, inflammation and disease, Jul. 2022, Corresponding author
      • Acute Cerebellar Inflammation and Related Ataxia: Mechanisms and Pathophysiology.
        Md Sorwer Alam Parvez; Gen Ohtsuki
        Brain sciences, 10 Mar. 2022, Peer-reviewed, Invited, Last author, Corresponding author
      • Microglia-triggered hypoexcitability plasticity of pyramidal neurons in the rat medial prefrontal cortex
        Yuki Yamawaki; Yayoi Wada; Sae Matsui; Gen Ohtsuki
        Current Research in Neurobiology, Feb. 2022, Peer-reviewed, Invited, Last author, Corresponding author
      • High permeability of the CSF flow in the juvenile mouse brain by brain-wide DCE-MRI
        Yayoi Wada; Hirohiko Imai; Yuki Yamawaki; Md Sorwer Alam Parvez; Sae Matsui; Gen Ohtsuki
        24 Sep. 2021
      • A Destruction Model of the Vascular and Lymphatic Systems in the Emergence of Psychiatric Symptoms.
        Kohei Segawa; Yukari Blumenthal; Yuki Yamawaki; Gen Ohtsuki
        Biology, 06 Jan. 2021, Peer-reviewed, Invited, Last author, Corresponding author
      • Psychosis symptoms following aberrant immunity in the brain.
        Akitoshi Ozaki; Yuki Yamawaki; Gen Ohtsuki
        Neural regeneration research, Mar. 2021, Peer-reviewed, Invited, Last author, Corresponding author
      • Synergistic excitability plasticity in cerebellar functioning
        Gen Ohtsuki; Mari Shishikura; Akitoshi Ozaki
        The FEBS Journal, 11 Nov. 2020, Peer-reviewed, Invited, Lead author, Corresponding author
      • Modification of synaptic-input clustering by intrinsic excitability plasticity on cerebellar Purkinje cell dendrites
        Gen Ohtsuki
        The Journal of Neuroscience, 21 Nov. 2019, Peer-reviewed, Lead author, Last author, Corresponding author
      • Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation
        Yamamoto, M.; Kim, M.; Imai, H.; Itakura, Y.; Ohtsuki, G.
        Cell Reports, 10 Sep. 2019, Peer-reviewed, Last author, Corresponding author
      • Microglia-triggered hyperexcitability in the cerebellum depresses animal behaviors
        Yamamoto M; Kim M; Imai H; Ohtsuki G
        bioRxiv, Jun. 2018
      • Synaptic Potential and Plasticity of an SK2 Channel Gate Regulate Spike Burst Activity in Cerebellar Purkinje Cells
        Ohtsuki, G.; Hansel, C.
        iScience, Mar. 2018, Peer-reviewed, Lead author
      • Activity-Dependent Plasticity of Spike Pauses in Cerebellar Purkinje Cells
        Grasselli, G.; He, Q.; Wan, V.; Adelman, J.P.; Ohtsuki, G.; Hansel, C.
        Cell Reports, Mar. 2016, Peer-reviewed
      • The Spontaneous Ataxic Mouse Mutant Tippy is Characterized by a Novel Purkinje Cell Morphogenesis and Degeneration Phenotype
        Shih, E.K.; Sekerková, G.; Ohtsuki, G.; Aldinger, K.A.; Chizhikov, V.V.; Hansel, C.; Mugnaini, E.; Millen, K.J.
        Cerebellum, Jun. 2015, Peer-reviewed
      • Similarity of visual selectivity among clonally related neurons in visual cortex
        Ohtsuki, G.; Nishiyama, M.; Yoshida, T.; Murakami, T.; Histed, M.; Lois, C.; Ohki, K.
        Neuron, Jul. 2012, Peer-reviewed
      • SK2 channel modulation contributes to compartment-specific dendritic plasticity in cerebellar Purkinje cells
        Ohtsuki, G.; Piochon, C.; Adelman, J.P.; Hansel, C.
        Neuron, Jul. 2012, Peer-reviewed
      • Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells
        Belmeguenai, A.; Hosy, E.; Bengtsson, F.; Pedroarena, C.M.; Piochon, C.; Teuling, E.; He, Q.; Ohtsuki, G.; De Jeu, M.T.G.; Elgersma, Y.; De Zeeuw, C.I.; Jörntell, H.; Hansel, C.
        Journal of Neuroscience, Oct. 2010, Peer-reviewed
      • Purkinje cell-specific knockout of the protein phosphatase PP2B impairs potentiation and cerebellar motor learning
        Schonewille, M.; Belmeguenai, A.; Koekkoek, S.K.; Houtman, S.H.; Boele, H.J.; van Beugen, B.J.; Gao, Z.; Badura, A.; Ohtsuki, G.; Amerika, W.E.; Hosy, E.; Hoebeek, F.E.; Elgersma, Y.; Hansel, C.; De Zeeuw, C.I.
        Neuron, Aug. 2010, Peer-reviewed
      • Purkinje cell NMDA receptors assume a key role in synaptic gain control in the mature cerebellum
        Piochon, C.; Levenes, C.; Ohtsuki, G.; Hansel, C.
        Journal of Neuroscience, 2010, Peer-reviewed
      • Climbing fiber signaling and cerebellar gain control
        Gen Ohtsuki; Claire Piochon; Christian Hansel
        FRONTIERS IN CELLULAR NEUROSCIENCE, Jul. 2009, Peer-reviewed
      • Bidirectional plasticity at developing climbing fiber-Purkinje neuron synapses
        Gen Ohtsuki; Tomoo Hirano
        EUROPEAN JOURNAL OF NEUROSCIENCE, Dec. 2008, Peer-reviewed
      • Enhancement of Both Long-Term Depression Induction and Optokinetic Response Adaptation in Mice Lacking Delphilin
        Tomonori Takeuchi; Gen Ohtsuki; Takashi Yoshida; Masahiro Fukaya; Tasuku Wainai; Manami Yamashita; Yoshito Yamazaki; Hisashi Mori; Kenji Sakimura; Susumu Kawamoto; Masahiko Watanabe; Tomoo Hirano; Masayoshi Mishina
        PLOS ONE, May 2008, Peer-reviewed
      • Threshold regulation of cerebellar LTD is critical for motor learning efficiency
        Tomonori Takeuchi; Gen Ohtsuki; Takashi Yoshida; Masahiro Fukaya; Tasuku Wainai; Hisashi Mori; Kenji Sakimura; Susumu Kawamoto; Masahiko Watanabe; Tomoo Hirano; Masayoshi Mishina
        NEUROSCIENCE RESEARCH, 2006, Peer-reviewed
      • Enhanced inhibitory synaptic transmission in the cerebellar molecular layer of the GluR delta 2 knock-out mouse
        G Ohtsuki; S Kawaguchi; M Mishina; T Hirano
        JOURNAL OF NEUROSCIENCE, Dec. 2004, Peer-reviewed
      • Oscillating Purkinje neuron activity causing involuntary eye movement in a mutant mouse deficient in the glutamate receptor delta 2 subunit
        T Yoshida; A Katoh; G Ohtsuki; M Mishina; T Hirano
        JOURNAL OF NEUROSCIENCE, Mar. 2004, Peer-reviewed

      Misc.

      • Threshold regulation of LTD at PF-PC synapses is crucial for the efficiency of OKR gain-increase adaptation
        Tomonori Takeuchi; Gen Ohtsuki; Takashi Yoshida; Masahiro Fukaya; Masahiko Watanabe; Tomoo Hitano; Masayoshi Mishina
        JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007
      • Facilitated cerebellar LTD and OKR adaptation in mice lacking Delphilin
        T Takeuchi; T Yoshida; G Ohtsuki; T Hirano; T Wainai; M Fukaya; M Watanabe; H Mori; K Sakimura; S Kawamoto; M Mishina
        JOURNAL OF PHARMACOLOGICAL SCIENCES, 2006

      Presentations

      • Immune-triggered excitability plasticity and psychiatric disease models
        Ohtsuki G
        The 25th Annual Meeting of the Korean Society for Brain and Neural Sciences (Incheon, Korea), Invited
      • Plasticity of the intrinsic excitability in the acute inflammation and psychiatric disease
        Ohtsuki G
        The 99th Annual Meeting of the Physiological Society of Japan (Sendai, Japan)
      • Intrinsic plasticity of the Purkinje-cell dendrites and immune stress
        Ohtsuki G
        1st China-Japan-Korea International Meeting and 44th Annual Meeting of the Japan Neuroscience Society (Kobe, Japan), Invited
      • Excitability plasticity and mental depressiveness during acute inflammation in the cerebellum
        大槻 元
        生理学研究所研究会 「ミクロからマクロに至る脳の構造と機能のダイナミクス」, 07 Nov. 2019
      • Aberrant Immunity in the Cerebellum Modulates Our Mood
        Gen Ohtsuki
        Neuroscience2019 in SfN - Press Conferrence, 21 Oct. 2019, Society for Neuroscience, Invited
      • Excitability plasticity and mental depressiveness during acute inflammation in the cerebellum
        Gen Ohtsuki
        WMU-IFAR, Wenzhou Medical University Institute for Advanced Research, 15 Sep. 2019, Jian Yang and Zi-Bing JIN, Invited
      • Functional Diversification in Clonal Cells after Eye-Opening in Mouse Visual Cortex
        Gen Ohtsuki
        京都大学大学院 理学研究科 ミニシンポジウム, Jul. 2015, 田川義晃
      • Functional organization of clonally related neurons in mouse visual cortex during development
        Ohtsuki G; Nishiyama M; Yoshida T; Murakami T; Histed M; Lois C; Ohki K
        日本神経科学学会, Jul. 2013, 日本神経科学学会
      • Activity-dependent control of signaling gains in neuronal dendrites
        Gen Ohtsuki
        Gordon Research Seminar Dendrites: Molecules, Structure & Function, 12 Mar. 2011, Georgeann S. Sack and Denise Cook
      • Long-term plasticity at cerebellar climbing fiber-Purkinje cell synapses
        Gen Ohtsuki
        Long-term plasticity at cerebellar climbing fiber-Purkinje cell synapses, 2010, ノースウエスタン大学 医学部, Invited
      • 生体の科学 Vol.72 No.1 [特集]小脳研究の未来 プルキンエ細胞興奮性の可塑性
        大槻 元; 山脇優輝; 谷垣宏亮, Joint work
        医学書院, Feb. 2021
      • Modulation of the neural function based on the plasticity of intrinsic excitability in the cerebellum
        Gen Ohtsuki, Contributor, Neurophysiology
        (公財)ブレインサイエンス振興財団, Jun. 2019, Not refereed

      External funds: Kakenhi

      • Dimensional approaches to psychiatric disorders associated with circuit abnormalities induced by genetic and environmental insults combined with inflammation in the brain
        Grant-in-Aid for Scientific Research (B)
        Basic Section 51030:Pathophysiologic neuroscience-related
        Kyoto University
        Takeshi Sakurai
        From 01 Apr. 2019, To 31 Mar. 2022, Project Closed
        社会性ストレス;思春期;マウスモデル;脳内炎症;精神疾患
      • Analysis of the functional development of clonally-related neurons in the visual cortex
        Grant-in-Aid for Young Scientists (A)
        Kyoto University;Kyushu University
        Gen Ohtsuki
        From 01 Apr. 2014, To 31 Mar. 2018, Project Closed
        クローン細胞;遺伝子改変マウス;大脳皮質;一次視覚野;生体下Ca2+イメージング;細胞位置機能解析;機能発達;3次元位置機能解析;大脳皮質一次視覚野;多細胞同時パッチクランプ;3次元位置機能解析;4細胞同時パッチクランプ記録
      • 複合炎症精神疾患モデルマウスの小脳機能低下の神経生理学的機序解明
        Grant-in-Aid for Scientific Research (C)
        Basic Section 46010:Neuroscience-general-related
        Kyoto University
        大槻 元
        From 01 Apr. 2023, To 31 Mar. 2026, Granted
        複合炎症ストレス;精神疾患;シナプス可塑性;免疫誘導型可塑性;小脳
      list
        Last Updated :2024/02/21

        Education

        Teaching subject(s)

        • From Apr. 2015, To Mar. 2016
          Interdisciplinary Life Science Course
          Fall, 理学研究科
        • From Apr. 2016, To Mar. 2017
          Interdisciplinary Life Science Course
          Fall, 理学研究科
        • From Apr. 2017, To Mar. 2018
          Interdisciplinary Life Science Course
          Fall, 理学研究科
        list
          Last Updated :2024/02/21

          Academic, Social Contribution

          Academic Contribution

          • Cerebellum-Related Learning and Psychiatric Diseases: Topic Editor (Frontiers In Cellular Neuroscience)
            Other
            Gen Ohtsuki, Taegon Kim, Peng Sun, Yong-Jun Chen & Egidio D‘Angelo

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