Basic Information

Faculty

• 薬学部

Professional Memberships

• 日本DDS学会
• 日本薬剤学会
• 日本薬物動態学会
• 日本薬学会

Academic Degree

• 薬学修士(京都大学)
• 博士（薬学）(京都大学)

Research History

• From Aug. 2016, To Present

  Kyoto University, Graduate School of Pharmaceutical Sciences, Professor
• From Apr. 2007, To Jul. 2016

  Kyoto University, Graduate School of Pharmaceutical Sciences, Associate Professor
• From Sep. 1997, To Mar. 2007

  Kyoto University, Graduate School of Pharmaceutical Sciences, Associate Professor
• From Apr. 1997, To Aug. 1997

  Kyoto University, Graduate School of Pharmaceutical Sciences, Junior Assistant Professor
• From Dec. 1991, To Mar. 1997

  Kyoto University, Faculty of Pharmaceutical Sciences, Junior Assistant Professor

Language of Instruction

• English
• Japanese

ID,URL

• J-Global ID

  200901026199528243

researchmap URL

• https://researchmap.jp/read0013274

Research

Research Topics, Overview of the research

• Research Topics

  Prediction and control of drug disposition behaviors in body, development of drug delivery systems
  

• Overview of the research

  Pharmacokinetics of a drug is a critical determinant of its pharmacological and toxicological activities. Aiming at optimization of therapeutic efficacy of drugs, I am developing nanomedicines that can control pharmacokinetic behaviors in the body, as well as prediction of pharmacokinetic properties by using informatic and computational techniques.

Research Interests

• DDS
• 薬物動態学
• 薬剤学
• Pharmaceutics; Pharmacokinetics; Drug Delivery System

Research Areas

• Life sciences, Clinical pharmacy
• Life sciences, Biomedical engineering
• Life sciences, Biomaterials
• Life sciences, Pharmaceuticals - analytical and physicochemistry

Papers

• Harnessing large language models for structured extraction of cytochrome P450-substance interactions from biomedical texts.

  Mariam Alkarmouty; Junya Ooka; Fumiyoshi Yamashita

  International journal of pharmaceutics, 24 Aug. 2025, Peer-reviewed, Last author, Corresponding author

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• Pharmacokinetic Simulation of Optimal Lopinavir and Ritonavir Dose Combination for COVID-19: Boosting Lopinavir With Ritonavir.

  Yuta Nakamaru; Ken-Ichi Sako; Naohito Ide; Yoshikazu Matsuda; Fumiyoshi Yamashita; Tomoji Maeda

  In vivo (Athens, Greece), 2025, Peer-reviewed

  
• Enhancing Intracellular Uptake of Ivermectin through Liposomal Encapsulation.

  Meryem Kocas; Fumiyoshi Yamashita; Tansel Comoglu; Qiyue Zhang

  AAPS PharmSciTech, 02 May 2025, Peer-reviewed

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• Protective role of hepatic non-parenchymal cells against drug-induced hepatocyte toxicity using perfluoropolyether-based microfluidic devices.

  Mengyang Wang; Qiyue Zhang; Kazuma Aoki; Yuriko Higuchi; Fumiyoshi Yamashita

  Toxicology letters, 01 May 2025, Peer-reviewed, Last author, Corresponding author

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• Prediction of plasma concentration-time profiles in mice using deep neural network integrated with pharmacokinetic models.

  Yuki Doi; Harutoshi Kato; Fumiyoshi Yamashita

  International journal of pharmaceutics, 16 Apr. 2025, Peer-reviewed, Last author, Corresponding author

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• Application of machine learning techniques in population pharmacokinetics/pharmacodynamics modeling.

  Mizuki Uno; Yuta Nakamaru; Fumiyoshi Yamashita

  Drug metabolism and pharmacokinetics, Jun. 2024, Peer-reviewed, Invited, Last author, Corresponding author

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• Programmed immobilization of living cells using independent click pairs

  Chengyuan Zhu; Hiroyasu Takemoto; Yuriko Higuchi; Fumiyoshi Yamashita

  Biochemical and Biophysical Research Communications, 05 Mar. 2024, Peer-reviewed, Last author

  
• Perfluoropolyether-Based Gut-Liver-on-a-Chip for the Evaluation of First-Pass Metabolism and Oral Bioavailability of Drugs

  Mengyang Wang; Yuko Sasaki; Rena Sakagami; Tomotaka Minamikawa; Masahiro Tsuda; Ryohei Ueno; Sayaka Deguchi; Ryosuke Negoro; Kanako So; Yuriko Higuchi; Ryuji Yokokawa; Kazuo Takayama; Fumiyoshi Yamashita

  ACS Biomaterials Science and Engineering, 2024, Peer-reviewed, Last author, Corresponding author

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• Relationship between Adsorption and Toxicity of Nephrotoxic Drugs in Microphysiological Systems (MPS)

  Ryohei Ueno; Masahiro Kuninori; Takumi Sumi; Ramin Banan Sadeghian; Yuji Takata; Azusa Iguchi; Masahiro Tsuda; Fumiyoshi Yamashita; Kentaro Ichikawa; Ryuji Yokokawa

  Micromachines, 29 Mar. 2023, Peer-reviewed

  
• Blautia coccoides JCM1395T Achieved Intratumoral Growth with Minimal Inflammation: Evidence for Live Bacterial Therapeutic Potential by an Optimized Sample Preparation and Colony PCR Method.

  Shoko Nomura; Erike W Sukowati; Yuko Shigeno; Maiko Takahashi; Akari Kato; Yoshimi Benno; Fumiyoshi Yamashita; Hidefumi Mukai

  Pharmaceutics, 19 Mar. 2023, Peer-reviewed

  
• Application of machine learning techniques to the analysis and prediction of drug pharmacokinetics.

  Ryosaku Ota; Fumiyoshi Yamashita

  Journal of controlled release : official journal of the Controlled Release Society, 16 Nov. 2022, Peer-reviewed, Last author, Corresponding author

  
• Application of perfluoropolyether elastomers in microfluidic drug metabolism assays.

  Mengyang Wang; Masahiro Tsuda; Sayaka Deguchi; Yuriko Higuchi; Kanako So; Yu-Suke Torisawa; Kazuo Takayama; Fumiyoshi Yamashita

  International journal of pharmaceutics, 05 Nov. 2022, Peer-reviewed, Last author, Corresponding author

  
• Cytosolic Ca2+-dependent Ca2+ release activity primarily determines the ER Ca2+ level in cells expressing the CPVT-linked mutant RYR2.

  Nagomi Kurebayashi; Takashi Murayama; Ryosaku Ota; Junji Suzuki; Kazunori Kanemaru; Takuya Kobayashi; Seiko Ohno; Minoru Horie; Masamitsu Iino; Fumiyoshi Yamashita; Takashi Sakurai

  The Journal of general physiology, 05 Sep. 2022, Peer-reviewed

  
• Disposition of E-selectin-targeting liposomes in tumor spheroids with a perfusable vascular network.

  Chanikarn Chantarasrivong; Ryu Okada; Yuuki Yamane; Xue Yang; Yuriko Higuchi; Miku Konishi; Naoko Komura; Hiromune Ando; Ryuji Yokokawa; Fumiyoshi Yamashita

  Drug metabolism and pharmacokinetics, 07 Aug. 2022, Peer-reviewed, Last author, Corresponding author

  
• Intestinal Permeability of Drugs in Caco-2 Cells Cultured in Microfluidic Devices.

  Yuko Sasaki; Hirotaka Tatsuoka; Masahiro Tsuda; Takumi Sumi; Yuka Eguchi; Kanako So; Yuriko Higuchi; Kazuo Takayama; Yusuke Torisawa; Fumiyoshi Yamashita

  Biological & pharmaceutical bulletin, 2022, Peer-reviewed, Last author

  
• CREB is a potential marker associated with drug-induced liver injury: Identification and validation through transcriptome database analysis

  Qiyue Zhang; Shiori Taniguchi; Kanako So; Masahiro Tsuda; Yuriko Higuchi; Mitsuru Hashida; Fumiyoshi Yamashita

  JOURNAL OF TOXICOLOGICAL SCIENCES, 2022, Peer-reviewed, Last author, Corresponding author

  
• Generation of Tetrafluoroethylene-Propylene Elastomer-Based Microfluidic Devices for Drug Toxicity and Metabolism Studies.

  Emi Sano; Sayaka Deguchi; Naoki Matsuoka; Masahiro Tsuda; Mengyang Wang; Kaori Kosugi; Chihiro Mori; Keisuke Yagi; Aya Wada; Shinsuke Yamasaki; Tsuyoshi Kawai; Masahide Yodogawa; Hiroyuki Mizuguchi; Norihito Nakazawa; Fumiyoshi Yamashita; Yu-Suke Torisawa; Kazuo Takayama

  ACS omega, 28 Sep. 2021, Peer-reviewed

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• Usability of Polydimethylsiloxane-Based Microfluidic Devices in Pharmaceutical Research Using Human Hepatocytes.

  Sayaka Deguchi; Masahiro Tsuda; Kaori Kosugi; Ayaka Sakamoto; Natsumi Mimura; Ryosuke Negoro; Emi Sano; Takuro Nobe; Kazuya Maeda; Hiroyuki Kusuhara; Hiroyuki Mizuguchi; Fumiyoshi Yamashita; Yu-Suke Torisawa; Kazuo Takayama

  ACS biomaterials science & engineering, 09 Aug. 2021, Peer-reviewed

  
• Dynamic changes in gene-to-gene regulatory networks in response to SARS-CoV-2 infection.

  Yoshihisa Tanaka; Kako Higashihara; Mai Adachi Nakazawa; Fumiyoshi Yamashita; Yoshinori Tamada; Yasushi Okuno

  Scientific reports, 27 May 2021, Peer-reviewed

  
• Minocycline Hydrochloride Controlled-release Microsphere Preparation Process Optimization Based on the Robust Design Method

  Mohammad Karim Haidar; Fumiyoshi Yamashita; Mitsuru Hashida

  Turkish Journal of Pharmaceutical Sciences, 2021, Peer-reviewed

  
• Complex network prediction using deep learning.

  Yoshihisa Tanaka; Ryosuke Kojima; Shoichi Ishida; Fumiyoshi Yamashita; Yasushi Okuno

  CoRR, 2021

  
• Prediction of HIV drug resistance based on the 3D protein structure: Proposal of molecular field mapping.

  Ryosaku Ota; Kanako So; Masahiro Tsuda; Yuriko Higuchi; Fumiyoshi Yamashita

  PloS one, 2021, Peer-reviewed, Last author, Corresponding author

  
• Biosorption-based 64Cu-labeling of bacteria for pharmacokinetic positron-emission tomography.

  Shoko Nomura; Maiko Takahashi; Akari Hashiba Kato; Yasuhiro Wada; Yasuyoshi Watanabe; Fumiyoshi Yamashita; Hidefumi Mukai

  International journal of pharmaceutics, 04 Oct. 2020, Peer-reviewed

  
• The Application of the in-Situ Hyperthermia Emission from Acoustic Nanodroplets for Theranostic Dual-Imaging and Antitumor Modalities.

  Rodi Abdalkader; Johan Unga; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  Biological & pharmaceutical bulletin, 01 Jul. 2020, Peer-reviewed

  
• System-Based Differential Gene Network Analysis for Characterizing a Sample-Specific Subnetwork.

  Yoshihisa Tanaka; Yoshinori Tamada; Marie Ikeguchi; Fumiyoshi Yamashita; Yasushi Okuno

  Biomolecules, 14 Feb. 2020, Peer-reviewed

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• Effects of Tissue Pressure on Transgene Expression Characteristics via Renal Local Administration Routes from Ureter or Renal Artery in the Rat Kidney.

  Natsuko Oyama; Haruyuki Takahashi; Maho Kawaguchi; Hirotaka Miyamoto; Koyo Nishida; Masako Tsurumaru; Mikiro Nakashima; Fumiyoshi Yamashita; Mitsuru Hashida; Shigeru Kawakami

  Pharmaceutics, 01 Feb. 2020, Peer-reviewed

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• Tissue suction-mediated gene transfer to the beating heart in mice.

  Yota Taniguchi; Natsuko Oyama; Shintaro Fumoto; Hideyuki Kinoshita; Fumiyoshi Yamashita; Kazunori Shimizu; Mitsuru Hashida; Shigeru Kawakami

  PloS one, 2020, Peer-reviewed

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• Evaluation of the Theranostic Potential of Perfluorohexane-Based Acoustic Nanodroplets.

  Rodi Abdalkader; Johan Unga; Fumiyoshi Yamashita; Kazuo Maruyama; Mitsuru Hashida

  Biological & pharmaceutical bulletin, 01 Dec. 2019, Peer-reviewed

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• Sialyl LewisX mimic-decorated liposomes for anti-angiogenic everolimus delivery to E-selectin expressing endothelial cells.

  Chanikarn Chantarasrivong; Yuriko Higuchi; Masahiro Tsuda; Yuuki Yamane; Mitsuru Hashida; Miku Konishi; Naoko Komura; Hiromune Ando; Fumiyoshi Yamashita

  RSC advances, 01 Jul. 2019, Peer-reviewed, Last author, Corresponding author

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• Ratiometric co-encapsulation and co-delivery of doxorubicin and paclitaxel by tumor-targeted lipodisks for combination therapy of breast cancer.

  Chunlai Feng; Haisheng Zhang; Jiaming Chen; Siqi Wang; Yuanrong Xin; Yang Qu; Qi Zhang; Wei Ji; Fumiyoshi Yamashita; Mengjie Rui; Ximing Xu

  International journal of pharmaceutics, 05 Apr. 2019, Peer-reviewed

  
• A model-based comparative meta-analysis of the efficacy of dolutegravir-based and efavirenz-based regimens in HIV-infected patients.

  Ota R; Ishii H; Tsuda M; Higuchi Y; Yamashita F

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Apr. 2019, Peer-reviewed, Last author, Corresponding author

  
• Development of mKO2 fusion proteins for real-time imaging and mechanistic investigation of the degradation kinetics of human IκBα in living cells.

  Rahimova N; Babazada H; Higuchi Y; Yamashita F; Hashida M

  Biochimica et biophysica acta. Molecular cell research, Feb. 2019, Peer-reviewed

  
• Binding and structure-kinetic relationship analysis of selective TLR4-targeted immunosuppressive self-assembling heparin nanoparticles

  Fumiyoshi Yamashita

  International Journal of Pharmaceutics, 01 Dec. 2018, Peer-reviewed, Last author, Corresponding author

  
• Urokinase injection-triggered clearance enhancement of a 4-arm PEG-conjugated Cu-64-bombesin analog tetramer: A novel approach for the improvement of PET imaging contrast

  Kazushi Matsumura; Maki Zouda; Yasuhiro Wada; Fumiyoshi Yamashita; Mitsuru Hashida; Yasuyoshi Watanabe; Hidefumi Mukai

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Jul. 2018, Peer-reviewed

  
• Dynamic Simulation of Drug Drug Interactions by Using Multi-level Physiological Modeling & Simulation Platforms

  Yamashita Fumiyoshi

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Mar. 2018, Peer-reviewed

  
• In silico approach

  Hiromi Baba; Jun-Ichi Takahara; Fumiyoshi Yamashita

  Skin Permeation and Disposition of Therapeutic and Cosmeceutical Compounds, 28 Nov. 2017, Peer-reviewed

  
• An Evolutionary Search Algorithm for Covariate Models in Population Pharmacokinetic Analysis

  Fumiyoshi Yamashita; Atsuto Fujita; Yukako Sasa; Yuriko Higuchi; Masahiro Tsuda; Mitsuru Hashida

  JOURNAL OF PHARMACEUTICAL SCIENCES, Sep. 2017, Peer-reviewed

  
• Synthesis and Functional Characterization of Novel Sialyl LewisX Mimic-Decorated Liposomes for E-selectin-Mediated Targeting to Inflamed Endothelial Cells

  Chanikarn Chantarasrivong; Akiharu Ueki; Ryutaro Ohyama; Johan Unga; Shinya Nakamura; Isao Nakanishi; Yuriko Higuchi; Shigeru Kawakami; Hiromune Ando; Akihiro Imamura; Hideharu Ishida; Fumiyoshi Yamashita; Makoto Kiso; Mitsuru Hashida

  MOLECULAR PHARMACEUTICS, May 2017, Peer-reviewed

  
• Quantitative prediction of ionization effect on human skin permeability

  Hiromi Baba; Yusuke Ueno; Mitsuru Hashida; Fumiyoshi Yamashita

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Apr. 2017, Peer-reviewed, Last author

  
• Anti-inflammatory Effect of Self-assembling Glycol-Split Glycosaminoglycan-Stearylamine Conjugates in Lipopolysaccharide-Stimulated Macrophages

  Shinya Yanamoto; Hasan Babazada; Shinya Sakai; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Apr. 2017, Peer-reviewed

  
• In Vitro Cellular Gene Delivery Employing a Novel Composite Material of Single-Walled Carbon Nanotubes Associated With Designed Peptides With Pegylation

  Takahisa Ohta; Yasuhiko Hashida; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF PHARMACEUTICAL SCIENCES, Mar. 2017, Peer-reviewed

  
• Effects of Expression Levels of WT and Mutant RyR2 on Ca2+ Homeostasis in HEK Cells

  Nagomi Kurebayashi; Takashi Murayama; Naoyuki Tetsuo; Ryosaku Ohta; Fumiyoshi Yamashita; Takashi Sakurai

  BIOPHYSICAL JOURNAL, Feb. 2017, Peer-reviewed

  
• In situ observation of nonmetallic inclusion formation in NiTi alloys

  Fumiyoshi Yamashita; Masamitsu Wakoh; Koji Ishikawa; Hiroyuki Shibata

  Materials Transactions, 2017, Peer-reviewed

  
• HD Physiology Project-Japanese efforts to promote multilevel integrative systems biology and physiome research

  Kazuharu Furutani; Kunichika Tsumoto; Yoshihisa Kurachi

  NPJ SYSTEMS BIOLOGY AND APPLICATIONS, 2017, Peer-reviewed

  
• Sustained Release of Mitomycin C from Its Conjugate with Single Walled Carbon Nanotubes Associated by Pegylated Peptide

  Takahisa Ohta; Yasuhiko Hashida; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Oct. 2016, Peer-reviewed

  
• Anti-MUC1 Aptamer/Negatively Charged Amino Acid Dendrimer Conjugates for Targeted Delivery to Human Lung Adenocarcinoma A549 Cells

  Marie Masuda; Shigeru Kawakami; Wassana Wijagkanalan; Tadaharu Suga; Yuki Fuchigami; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Oct. 2016, Peer-reviewed

  
• Development of Novel Drug and Gene Delivery Carriers Composed of Single- Walled Carbon Nanotubes and Designed Peptides With PEGylation

  Takahisa Ohta; Yasuhiko Hashida; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF PHARMACEUTICAL SCIENCES, Sep. 2016, Peer-reviewed

  
• Distribution of Silver Nanoparticles to Breast Milk and Their Biological Effects on Breast-Fed Offspring Mice

  Yuki Morishita; Yasuo Yoshioka; Yuya Takimura; Yuki Shimizu; Yuki Namba; Nao Nojiri; Takuya Ishizaka; Keizo Takao; Fumiyoshi Yamashita; Kazuhiro Takuma; Yukio Ago; Kazuya Nagano; Yohei Mukai; Haruhiko Kamada; Shin-ichi Tsunoda; Shigeru Saito; Toshio Matsuda; Mitsuru Hashida; Tsuyoshi Miyakawa; Kazuma Higashisaka; Yasuo Tsutsumi

  ACS NANO, Sep. 2016, Peer-reviewed

  
• Development of PEGylated Cysteine-Modified Lysine Dendrimers with Multiple Reduced Thiols To Prevent Hepatic Ischemia/Reperfusion Injury

  Hidemasa Katsumi; Makiya Nishikawa; Rikiya Hirosaki; Tatsuya Okuda; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida; Toshiyasu Sakane; Akira Yamamoto

  MOLECULAR PHARMACEUTICS, Aug. 2016, Peer-reviewed

  
• Development of a Support Vector Machine-Based System to Predict Whether a Compound Is a Substrate of a Given Drug Transporter Using Its Chemical Structure

  Atsushi Ose; Kota Toshimoto; Kazushi Ikeda; Kazuya Maeda; Shuya Yoshida; Fumiyoshi Yamashita; Mitsuru Hashida; Takashi Ishida; Yutaka Akiyama; Yuichi Sugiyama

  JOURNAL OF PHARMACEUTICAL SCIENCES, Jul. 2016, Peer-reviewed

  
• Optimization of renal transfection using a renal suction-mediated transfection method in mice

  Yota Taniguchi; Shigeru Kawakami; Yuki Fuchigami; Natsuko Oyama; Fumiyoshi Yamashita; Satoshi Konishi; Kazunori Shimizu; Mitsuru Hashida

  JOURNAL OF DRUG TARGETING, May 2016, Peer-reviewed

  
• ウロキナーゼ静脈内投与による樹状PEG修飾64Cuボンベシンアナログテトラマーのスイッチング型腎クリアランスを意図したPETプローブ

  向井 英史; 松村 一史; 造田 真希; 林中 恵美; 山下 富義; 橋田 充; 和田 康弘; 渡辺 恭良

  JSMI Report, Apr. 2016, Peer-reviewed

  
• Modeling and simulation of pharmacokinetic drug-drug interaction caused by induction of metabolic enzymes.

  Yamashita F

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica, Feb. 2016, Peer-reviewed

  
• Modeling and Prediction of Solvent Effect on Human Skin Permeability using Support Vector Regression and Random Forest

  Hiromi Baba; Jun-ichi Takahara; Fumiyoshi Yamashita; Mitsuru Hashida

  PHARMACEUTICAL RESEARCH, Nov. 2015, Peer-reviewed

  
• Multiple Linear Regression Analysis Indicates Association of P-Glycoprotein Substrate or Inhibitor Character with Bitterness Intensity, Measured with a Sensor

  Kentaro Yano; Suzune Mita; Kaori Morimoto; Tamami Haraguchi; Hiroshi Arakawa; Miyako Yoshida; Fumiyoshi Yamashita; Takahiro Uchida; Takuo Ogihara

  JOURNAL OF PHARMACEUTICAL SCIENCES, Sep. 2015, Peer-reviewed

  
• Development of fluorous lipid-based nanobubbles for efficiently containing perfluoropropane.

  Yusuke Oda; Ryo Suzuki; Tatsuya Mori; Hideyo Takahashi; Hideaki Natsugari; Daiki Omata; Johan Unga; Hitoshi Uruga; Mutsumi Sugii; Shigeru Kawakami; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida; Kazuo Maruyama

  International journal of pharmaceutics, 20 Jun. 2015, Peer-reviewed

  
• 生理条件下代謝開裂部位導入による64Cu標識ボンベシンアナログテトラマーを用いた癌PETイメージングの画像コントラスト改善

  松村 一史; 向井 英史; 造田 真希; 高橋 麻衣子; 林中 恵美; 山下 富義; 橋田 充; 和田 康弘; 渡辺 恭良

  日本DDS学会学術集会プログラム予稿集, Jun. 2015, Peer-reviewed

  
• Long-term in vivo gene expression in mouse kidney using phi C31 integrase and electroporation

  Yuki Otani; Shigeru Kawakami; Hidefumi Mukai; Yuki Fuchigami; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF DRUG TARGETING, Jun. 2015, Peer-reviewed

  
• Evaluation of the potential of doxorubicin loaded microbubbles as a theranostic modality using a murine tumor model

  Rodi Abdalkader; Shigeru Kawakami; Johan Unga; Ryo Suzuki; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  ACTA BIOMATERIALIA, Jun. 2015, Peer-reviewed

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• Artificial neural network analysis for predicting human percutaneous absorption taking account of vehicle properties

  Tomomi Atobe; Masaaki Mori; Fumiyoshi Yamashita; Mitsuru Hashida; Hirokazu Kouzuki

  JOURNAL OF TOXICOLOGICAL SCIENCES, Apr. 2015, Peer-reviewed

  
• Synthesis and evaluation of glyco-coated liposomes as drug carriers for active targeting in drug delivery systems

  Akiharu Ueki; Keita Un; Yuka Mino; Mitsuru Yoshida; Shigeru Kawakami; Hiromune Ando; Hideharu Ishida; Fumiyoshi Yamashita; Mitsuru Hashida; Makoto Kiso

  CARBOHYDRATE RESEARCH, Mar. 2015, Peer-reviewed

  
• Multi-layer hierarchical physiology-based modeling for the prediction of pharmacokinetic drug-drug interactions

  Fumiyoshi Yamashita

  Journal of Pharmacological Sciences, 2015

  
• In silico Techniques for Pharmaceutical Development

  Yamashita Fumiyoshi

  Journal of Pharmaceutical Science and Technology, Japan, 2015

  
• Kidney-selective gene transfection using anionic bubble lipopolyplexes with renal ultrasound irradiation in mice

  Tomoaki Kurosaki; Shigeru Kawakami; Yuriko Higuchi; Ryo Suzuki; Kazuo Maruyama; Hitoshi Sasaki; Fumiyoshi Yamashita; Mitsuru Hashida

  NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, Nov. 2014, Peer-reviewed

  
• Enhancement of the anti-tumor effect of DNA vaccination using an ultrasound-responsive mannose-modified gene carrier in combination with doxorubicin-encapsulated PEGylated liposomes

  Mitsuru Yoshida; Shigeru Kawakami; Yusuke Kono; Keita Un; Yuriko Higuchi; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Nov. 2014, Peer-reviewed

  
• Self-assembling lipid modified glycol-split heparin nanoparticles suppress lipopolysaccharide-induced inflammation through TLR4-NF-kappa B signaling

  Hasan Babazada; Fumiyoshi Yamashita; Shinya Yanamoto; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Nov. 2014, Peer-reviewed

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• Suppression of experimental arthritis with self-assembling glycol-split heparin nanoparticles via inhibition of TLR4-NF-kappa B signaling

  Hasan Babazada; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Nov. 2014, Peer-reviewed

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• Evaluation of inflammatory responses due to small interfering RNA transfer using unmodified- and mannose-modified bubble lipoplexes with ultrasound exposure in primary cultured macrophages

  Mitsuru Yoshida; Shigeru Kawakami; Keita Un; Yusuke Kono; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF DRUG TARGETING, Sep. 2014, Peer-reviewed

  
• Targeted gene integration using the combination of a sequence-specific DNA-binding protein and phiC31 integrase

  Hideyuki Nakanishi; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF BIOTECHNOLOGY, Sep. 2014, Peer-reviewed

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• Antitumor effect of nuclear factor-B decoy transfer by mannose-modified bubble lipoplex into macrophages in mouse malignant ascites

  Yusuke Kono; Shigeru Kawakami; Yuriko Higuchi; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  CANCER SCIENCE, Aug. 2014, Peer-reviewed

  
• Preparation of immunostimulatory single-walled carbon nanotube/CpG DNA complexes and evaluation of their potential in cancer immunotherapy

  Shuwen Zhou; Yasuhiko Hashida; Shigeru Kawakami; Junya Mihara; Tomokazu Umeyama; Hiroshi Imahori; Tatsuya Murakami; Fumiyoshi Yamashita; Mitsuru Hashida

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Aug. 2014, Peer-reviewed

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• Tumour-associated macrophages targeted transfection with NF-kappa B decoy/mannose-modified bubble lipoplexes inhibits tumour growth in tumour-bearing mice

  Yusuke Kono; Shigeru Kawakami; Yuriko Higuchi; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF DRUG TARGETING, Jun. 2014, Peer-reviewed

  
• 樹状型ポリエチレングリコール修飾によるボンベシンアナログ誘導体PETプローブの腫瘍内貯留性向上

  向井 英史; 松村 一史; 造田 真希; 高橋 麻衣子; 林中 恵美; 山下 富義; 橋田 充; 和田 康弘; 渡辺 恭良

  JSMI Report, May 2014, Peer-reviewed

  
• 64Cu標識前立腺癌標的ペプチドDUP-1の化学修飾がもたらす代謝安定性と腫瘍集積性の向上

  松村 一史; 向井 英史; 造田 真希; 高橋 麻衣子; 林中 恵美; 山下 富義; 橋田 充; 和田 康弘; 渡辺 恭良

  JSMI Report, May 2014, Peer-reviewed

  
• Development of PEGylated serum albumin with multiple reduced thiols as a long-circulating scavenger of reactive oxygen species for the treatment of fulminant hepatic failure in mice

  Hidemasa Katsumi; Makiya Nishikawa; Kazushi Nishiyama; Rikiya Hirosaki; Narumi Nagamine; Haruka Okamoto; Hironori Mizuguchi; Kosuke Kusamori; Hiroyuki Yasui; Fumiyoshi Yamashita; Mitsuru Hashida; Toshiyasu Sakane; Akira Yamamoto

  FREE RADICAL BIOLOGY AND MEDICINE, Apr. 2014, Peer-reviewed

  
• Inhibition of Cancer Cell Growth by GRP78 siRNA Lipoplex via Activation of Unfolded Protein Response

  Kazushi Matsumura; Chika Sakai; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Apr. 2014, Peer-reviewed

  
• 適度な血中循環の延長と多点認識を目指した化学修飾による癌PETイメージング用ペプチドプローブの改良

  松村 一史; 向井 英史; 造田 真希; 高橋 麻衣子; 林中 恵美; 川上 茂; 山下 富義; 橋田 充; 和田 康弘; 渡辺 恭良

  日本薬学会年会要旨集, Mar. 2014, Peer-reviewed

  
• Development of anionic bubble lipopolyplexes for efficient and safe gene transfection with ultrasound exposure in mice

  Tomoaki Kurosaki; Shigeru Kawakami; Yuriko Higuchi; Ryo Suzuki; Kazuo Maruyama; Hitoshi Sasaki; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Feb. 2014, Peer-reviewed

  
• Bilinear Model for the Size-Dependency of the CYP3A4 Inhibitory Activity of Structurally Diverse Compounds

  Peter Buchwald; Fumiyoshi Yamashita

  MOLECULAR INFORMATICS, Jan. 2014, Peer-reviewed

  
• In Vitro Evaluation of Inhibitory Effect of Nuclear Factor-KappaB Activity by Small Interfering RNA on Pro-tumor Characteristics of M2-Like Macrophages

  Yusuke Kono; Shigeru Kawakami; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jan. 2014, Peer-reviewed

  
• Photothermal ablation of tumor cells using a single-walled carbon nanotube-peptide composite

  Yasuhiko Hashida; Hironori Tanaka; Shuwen Zhou; Shigeru Kawakami; Fumiyoshi Yamashita; Tatsuya Murakami; Tomokazu Umeyama; Hiroshi Imahori; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Jan. 2014, Peer-reviewed

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• Promotion of innovative medicinal and medical sciences based on systems-based understandings

  Fumiyoshi Yamashita

  Drug Delivery System, 2014, Peer-reviewed

  
• Prediction of drug-drug interaction relating to the induction of drug metabolizing enzymes

  Shuya Yoshida; Fumiyoshi Yamashita

  Drug Delivery System, 2014, Peer-reviewed

  
• Factors Influencing the Surface Modification of Mesenchymal Stem Cells with Fluorescein-Pegylated Lipids

  Yoshimasa Takafuji; Yuriko Higuchi; Atsushi Muro; Kohei Oshiro; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Nov. 2013, Peer-reviewed

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• Automated Extraction of Information on Chemical-P-glycoprotein Interactions from the Literature

  Shuya Yoshida; Fumiyoshi Yamashita; Atsushi Ose; Kazuya Maeda; Yuichi Sugiyama; Mitsuru Hashida

  JOURNAL OF CHEMICAL INFORMATION AND MODELING, Oct. 2013, Peer-reviewed

  
• Pivotal role of oxidative stress in tumor metastasis under diabetic conditions in mice

  Mai Ikemura; Makiya Nishikawa; Kosuke Kusamori; Miho Fukuoka; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Sep. 2013, Peer-reviewed

  
• Sedative effects of inhaled benzylacetone and structural features contributing to its activity

  Takashi Miyoshi; Michiho Ito; Takashi Kitayama; Sachiko Isomori; Fumiyoshi Yamashita

  Biological and Pharmaceutical Bulletin, Sep. 2013, Peer-reviewed

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• Modeling of Rifampicin-Induced CYP3A4 Activation Dynamics for the Prediction of Clinical Drug-Drug Interactions from In Vitro Data

  Fumiyoshi Yamashita; Yukako Sasa; Shuya Yoshida; Akihiro Hisaka; Yoshiyuki Asai; Hiroaki Kitano; Mitsuru Hashida; Hiroshi Suzuki

  PLOS ONE, Sep. 2013, Peer-reviewed

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• Pharmacokinetic considerations for targeted drug delivery

  Fumiyoshi Yamashita; Mitsuru Hashida

  ADVANCED DRUG DELIVERY REVIEWS, Jan. 2013, Peer-reviewed

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• The role of inter-segmental differences in P-glycoprotein expression and activity along the rat small intestine in causing the double-peak phenomenon of substrate plasma concentration

  Sho Wada; Takashi Kano; Suzune Mita; Yoko Idota; Kaori Morimoto; Yamashita Fumiyoshi; Ogihara Takuo

  Drug Metabolism and Pharmacokinetics, 2013, Peer-reviewed

  
• Structure-Activity Relationship Modeling for Predicting Interactions with Pregnane X Receptor by Recursive Partitioning

  Shuya Yoshida; Fumiyoshi Yamashita; Takayuki Itoh; Mitsuru Hashida

  DRUG METABOLISM AND PHARMACOKINETICS, Oct. 2012, Peer-reviewed

  
• Evaluation of Long-Term Gene Expression in Mouse Liver Using PhiC31 Integrase and Hydrodynamic Injection

  Yoshiaki Umemoto; Shigeru Kawakami; Yuki Otani; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jul. 2012, Peer-reviewed

  
• Bovine Serum Albumin as a Lyoprotectant for Preparation of DNA Dry Powder Formulations Using the Spray-Freeze Drying Method

  Masashi Tsukamoto; Tomoyuki Okuda; Hirokazu Okamoto; Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jul. 2012, Peer-reviewed

  
• Efficient suppression of murine intracellular adhesion molecule-1 using ultrasound-responsive and mannose-modified lipoplexes inhibits acute hepatic inflammation

  Keita Un; Shigeru Kawakami; Mitsuru Yoshida; Yuriko Higuchi; Ryo Suzuki; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  HEPATOLOGY, Jul. 2012, Peer-reviewed

  
• Computer-based Evolutionary Search for a Nonlinear Conversion Function for Establishing In Vitro-In Vivo Correlation (IVIVC) of Oral Drug Formulations

  Fumiyoshi Yamashita; Atsuto Fujita; Xingyi Zhang; Yukako Sasa; Kiyoshi Mihara; Mitsuru Hashida

  DRUG METABOLISM AND PHARMACOKINETICS, Jun. 2012, Peer-reviewed

  
• Enhancement of gene expression by transcriptional activation using doxorubicin-loaded liposome/pDNA complexes

  K. Un; Y. Kono; M. Yoshida; F. Yamashita; S. Kawakami; M. Hashida

  PHARMAZIE, May 2012, Peer-reviewed

  
• Development of bone-targeted catalase derivatives for inhibition of bone metastasis of tumor cells in mice

  Yunlong Zheng; Makiya Nishikawa; Mai Ikemura; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF PHARMACEUTICAL SCIENCES, Feb. 2012, Peer-reviewed

  
• The involvement of NK cell activation following intranasal administration of CpG DNA lipoplex in the prevention of pulmonary metastasis and peritoneal dissemination in mice

  Shuwen Zhou; Shigeru Kawakami; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  CLINICAL & EXPERIMENTAL METASTASIS, Jan. 2012, Peer-reviewed

  
• Involvement of activated transcriptional process in efficient gene transfection using unmodified and mannose-modified bubble lipoplexes with ultrasound exposure

  Keita Un; Shigeru Kawakami; Yuriko Higuchi; Ryo Suzuki; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Dec. 2011, Peer-reviewed

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• Development of lysine-histidine dendron modified chitosan for improving transfection efficiency in HEK293 cells

  Kai-Ling Chang; Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Dec. 2011, Peer-reviewed

  
• Polyamidoamine dendrimer-conjugated quantum dots for efficient labeling of primary cultured mesenchymal stem cells

  Yuriko Higuchi; Can Wu; Kai-Ling Chang; Kei Irie; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOMATERIALS, Oct. 2011, Peer-reviewed

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• Comparison of piggyBac transposition efficiency between linear and circular donor vectors in mammalian cells

  Hideyuki Nakanishi; Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF BIOTECHNOLOGY, Jul. 2011, Peer-reviewed

  
• The elucidation of gene transferring mechanism by ultrasound-responsive unmodified and mannose-modified lipoplexes

  Keita Un; Shigeru Kawakami; Mitsuru Yoshida; Yuriko Higuchi; Ryo Suzuki; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOMATERIALS, Jul. 2011, Peer-reviewed

  
• Mechanisms of enhanced gene expression by gene transfer using ultrasound-responsive and mannose-modified gene carriers

  Keita Un; Shigeru Kawakami; Mitsuru Yoshida; Ryo Suzuki; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  Molecular Therapy, Jun. 2011, Peer-reviewed

  
• Development of polyamidoamine dendrimer-conjugated quantum dots for tracing primary cultured mesenchymal stem cells in mice

  Yuriko Higuchi; Wu Can; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  Molecular Therapy, Jun. 2011, Peer-reviewed

  
• Evaluation of Osteoclastogenesis via NF kappa B Decoy/mannosylated Cationic Liposome-Mediated Inhibition of Pro-inflammatory Cytokine Production from Primary Cultured Macrophages

  Thuy Duong Dinh; Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  PHARMACEUTICAL RESEARCH, Apr. 2011, Peer-reviewed

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• Suppression of Melanoma Growth and Metastasis by DNA Vaccination Using an Ultrasound-Responsive and Mannose-Modified Gene Carrier

  Keita Un; Shigeru Kawakami; Ryo Suzuki; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  MOLECULAR PHARMACEUTICS, Mar. 2011, Peer-reviewed

  
• Automated Information Extraction and Structure-Activity Relationship Analysis of Cytochrome P450 Substrates

  Fumiyoshi Yamashita; Chunlai Feng; Shuya Yoshida; Takayuki Itoh; Mitsuru Hashida

  JOURNAL OF CHEMICAL INFORMATION AND MODELING, Feb. 2011, Peer-reviewed

  
• Formulation and Pharmacokinetic Evaluation of Tetracycline-Loaded Solid Lipid Nanoparticles for Subcutaneous Injection in Mice

  Xi-ming Xu; Yan-song Wang; Rong-ying Chen; Chun-lai Feng; Feng Yao; Shan-shan Tong; Li Wang; Fumiyoshi Yamashita; Jiang-nan Yu

  CHEMICAL & PHARMACEUTICAL BULLETIN, Feb. 2011, Peer-reviewed

  
• Intratracheally instilled mannosylated cationic liposome/NF kappa B decoy complexes for effective prevention of LPS-induced lung inflammation

  Wassana Wijagkanalan; Shigeru Kawakami; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Jan. 2011, Peer-reviewed

  
• Improvement of Insulin Resistance by Removal of Systemic Hydrogen Peroxide by PEGylated Catalase in Obese Mice

  Mai Ikemura; Makiya Nishikawa; Kenji Hyoudou; Yuki Kobayashi; Fumiyoshi Yamashita; Mitsuru Hashida

  MOLECULAR PHARMACEUTICS, Nov. 2010, Peer-reviewed

  
• Development of an ultrasound-responsive and mannose-modified gene carrier for DNA vaccine therapy

  Keita Un; Shigeru Kawakami; Ryo Suzuki; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOMATERIALS, Oct. 2010, Peer-reviewed

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• Key Physiological Phenomena Governing Transgene Expression Based on Tissue Pressure-Mediated Transfection in Mice

  Hidefumi Mukai; Shigeru Kawakami; Haruyuki Takahashi; Kyosuke Satake; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Sep. 2010, Peer-reviewed

  
• A novel multi-dimensional visualization technique for understanding the design parameters of drug formulations

  Fumiyoshi Yamashita; Takayuki Itoh; Shuya Yoshida; Mohammad K. Haidar; Mitsuru Hashida

  COMPUTERS & CHEMICAL ENGINEERING, Aug. 2010, Peer-reviewed

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• Anionic Amino Acid Dendrimer-Trastuzumab Conjugates for Specific Internalization in HER2-Positive Cancer Cells

  Takuya Miyano; Wassana Wijagkanalan; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  MOLECULAR PHARMACEUTICS, Jul. 2010, Peer-reviewed

  
• Enhanced growth inhibition of metastatic lung tumors by intravenous injection of ATRA-cationic liposome/IL-12 pDNA complexes in mice

  P. Charoensit; S. Kawakami; Y. Higuchi; F. Yamashita; M. Hashida

  CANCER GENE THERAPY, Jul. 2010, Peer-reviewed

  
• Efficient Gene Transfection by Histidine-Modified Chitosan through Enhancement of Endosomal Escape

  Kai-Ling Chang; Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOCONJUGATE CHEMISTRY, Jun. 2010, Peer-reviewed

  
• piggyBac Transposon-mediated Long-term Gene Expression in Mice

  Hideyuki Nakanishi; Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  MOLECULAR THERAPY, Apr. 2010, Peer-reviewed

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• Intranasal administration of CpG DNA lipoplex prevents pulmonary metastasis in mice

  Shuwen Zhou; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  CANCER LETTERS, Jan. 2010, Peer-reviewed

  
• Enhanced Transfection Efficiency into Macrophages and Dendritic Cells by a Combination Method Using Mannosylated Lipoplexes and Bubble Liposomes with Ultrasound Exposure

  Keita Un; Shigeru Kawakami; Ryo Suzuki; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  HUMAN GENE THERAPY, Jan. 2010, Peer-reviewed

  
• Development and Therapeutic Application of Transposon-based Vectors

  Hideyuki Nakanishi; Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Dec. 2009, Peer-reviewed

  
• GLYCOSYLATED LIPOSOMES FOR THE TARGETED DELIVERY OF SIRNA AND CPG DNA

  Shigeru Kawakami; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF GENE MEDICINE, Dec. 2009, Peer-reviewed

  
• Prevention of ischemia/reperfusion injury by hepatic targeting of nitric oxide in mice

  Hidemasa Katsumi; Makiya Nishikawa; Hiroyuki Yasui; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Nov. 2009, Peer-reviewed

  
• Pressure-Mediated Transfection of Murine Spleen and Liver

  Hidefumi Mukai; Shigeru Kawakami; Yuki Kamiya; Fan Ma; Haruyuki Takahashi; Kyosuke Satake; Kyohei Terao; Hidetoshi Kotera; Fumiyoshi Yamashita; Mitsuru Hashida

  HUMAN GENE THERAPY, Oct. 2009, Peer-reviewed

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• Prevention of pulmonary metastasis from subcutaneous tumors by binary system-based sustained delivery of catalase

  Kenji Hyoudou; Makiya Nishikawa; Mai Ikemura; Yuki Kobayashi; Adam Mendelsohn; Nobuhiko Miyazaki; Yasuhiko Tabata; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Jul. 2009, Peer-reviewed

  
• Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles

  Tomoyuki Okuda; Shigeru Kawakami; Yuriko Higuchi; Taku Satoh; Yoshimi Oka; Masayuki Yokoyama; Fumiyoshi Yamashita; Mitsuru Hashida

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, May 2009, Peer-reviewed

  
• Mannosylated Cationic Liposomes/CpG DNA Complex for the Treatment of Hepatic Metastasis after Intravenous Administration in Mice

  Yukari Kuramoto; Shigeru Kawakami; Shuwen Zhou; Kyouichi Fukuda; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF PHARMACEUTICAL SCIENCES, Mar. 2009, Peer-reviewed

  
• 経腎動脈及び逆行性経輪尿管投与を介した腎組織押圧法の腎臓内遺伝子発現部位制御

  高橋 晴之; 向井 英史; 川上 茂; 山下 富義; 橋田 充

  日本薬学会年会要旨集, Mar. 2009, Peer-reviewed

  
• 組織押圧法及び電気穿孔法を利用した遺伝子導入による炎症性サイトカイン産生の評価

  向井 英史; 佐竹 恭輔; 川上 茂; 山下 富義; 橋田 充

  日本薬学会年会要旨集, Mar. 2009, Peer-reviewed

  
• Immunostimulatory Characteristics Induced by Linear Polyethyleneimine-Plasmid DNA Complexes in Cultured Macrophages

  Yasunori Saito; Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  HUMAN GENE THERAPY, Feb. 2009, Peer-reviewed

  
• Systematic Research of Peptide Spacers Controlling Drug Release from Macromolecular Prodrug System, Carboxymethyldextran Polyalcohol-Peptide-Drug Conjugates

  Yoshinobu Shiose; Hiroshi Kuga; Hitoshi Ohki; Masahiro Ikeda; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOCONJUGATE CHEMISTRY, Jan. 2009, Peer-reviewed

  
• SOD derivatives prevent metastatic tumor growth aggravated by tumor removal

  Kenji Hyoudou; Makiya Nishikawa; Yuki Kobayashi; Mai Ikemura; Fumiyoshi Yamashita; Mitsuru Hashida

  CLINICAL & EXPERIMENTAL METASTASIS, Sep. 2008, Peer-reviewed

  
• Hydrogen peroxide-mediated nuclear factor kappa B activation in both liver and tumor cells during initial stages of hepatic metastasis

  Yuki Kobayashi; Makiya Nishikawa; Kenji Hyoudou; Fumiyoshi Yamashita; Mitsuru Hashida

  CANCER SCIENCE, Aug. 2008, Peer-reviewed

  
• Block copolymer design for stable encapsulation of N-(4-hydroxyphenyl)retinamide into polymeric micelles in mice

  Tomoyuki Okuda; Shigeru Kawakami; Masayuki Yokoyama; Tatsuhiro Yamamoto; Fumiyoshi Yamashita; Mitsuru Hashida

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Jun. 2008, Peer-reviewed

  
• Use of mannosylated cationic liposomes/immunostimulatory CpG DNA complex for effective inhibition of peritoneal dissemination in mice

  Yukari Kuramoto; Shigeru Kawakami; Shuwen Zhou; Kyouichi Fukuda; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF GENE MEDICINE, Apr. 2008, Peer-reviewed

  
• Efficient peritoneal dissemination treatment obtained by an immunostimulatory phosphorothioate-type CpG DNA/cationic liposome complex in mice

  Yukari Kuramoto; Shigeru Kawakami; Shuwen Zhou; Kyouichi Fukuda; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Mar. 2008, Peer-reviewed

  
• Liposomal In vivo Gene Delivery

  Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  Modern Biopharmaceuticals: Design, Development and Optimization, 05 Feb. 2008, Peer-reviewed

  
• Novel hierarchical classification and visualization method for multiobjective optimization of drug properties: Application to structure-activity relationship analysis of cytochrome P450 metabolism

  Fumiyoshi Yamashita; Hideto Hara; Takayuki Ito; Mitsuru Hashida

  JOURNAL OF CHEMICAL INFORMATION AND MODELING, Feb. 2008, Peer-reviewed

  
• Prevention of hepatic ischemia/reperfusion injury by prolonged delivery of nitric oxide to the circulating blood in mice

  Hidemasa Katsumi; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida

  TRANSPLANTATION, Jan. 2008, Peer-reviewed

  
• Efficient targeting to alveolar macrophages by intratracheal administration of mannosylated liposomes in rats

  Wassana Wijagkanalan; Shigeru Kawakami; Mitsuko Takenaga; Rie Igarashi; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Jan. 2008, Peer-reviewed

  
• Insertion of nuclear factor-kB binding sequence into plasmid DNA for increased transgene expression in colon carcinoma cells

  Oranuch Thanaketpaisarn; Makiya Nishikawa; Takayuki Okabe; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF BIOTECHNOLOGY, Jan. 2008, Peer-reviewed

  
• Relationship between drug release of DE-310, macromolecular prodrug of DX-8951f, and cathepsins activity in several tumors

  Yoshinobu Shiose; Yusuke Ochi; Hiroshi Kuga; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Dec. 2007, Peer-reviewed

  
• Combining cisplatin with cationized catalase decreases nephrotoxicity while improving antitumor activity

  S-F Ma; M. Nishikawa; K. Hyoudou; R. Takahashi; M. Ikemura; Y. Kobayashi; F. Yamashita; M. Hashida

  KIDNEY INTERNATIONAL, Dec. 2007, Peer-reviewed

  
• Automated extraction of information from the literature on chemical-CYP3A4 interactions

  Chunlai Feng; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CHEMICAL INFORMATION AND MODELING, Nov. 2007, Peer-reviewed

  
• Cationized catalase-loaded hydrogel for growth inhibition of peritoneally disseminated tumor cells

  Kenji Hyoudou; Makiya Nishikawa; Mai Ikemura; Yuki Kobayashi; Adam Mendelsohn; Nobuhiko Miyazaki; Yasuhiko Tabata; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Sep. 2007, Peer-reviewed

  
• Efficient protection by cationized catalase against H2O2 injury in primary cultured alveolar epithelial cells

  Takayuki Nemoto; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Aug. 2007, Peer-reviewed

  
• Development of an antigen-presenting cell-targeted DNA vaccine against melanoma by mannosylated liposomes

  Yan Lu; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOMATERIALS, Jul. 2007, Peer-reviewed

  
• Optimization of tumor-selective targeting by basic fibroblast growth factor-binding peptide grafted PEGylated liposomes

  Takeshi Terada; Miki Mizobata; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Jun. 2007, Peer-reviewed

  
• Inhibition of peritoneal dissemination of tumor cells by cationized catalase in mice

  Kenji Hyoudou; Makiya Nishikawa; Yuki Kobayashi; Sakiko Mukai; Mai Ikemura; Yukari Kuramoto; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, May 2007, Peer-reviewed

  
• メカニカルマッサージによる腎臓へのsiRNAデリバリー

  向井 英史; 川上 茂; 山下 富義; 橋田 充

  Drug Delivery System, May 2007, Peer-reviewed

  
• メカニカルマッサージによる肝臓選択的遺伝子導入法の開発

  神谷 勇輝; 川上 茂; 向井 英史; 山下 富義; 橋田 充

  薬剤学: 生命とくすり, May 2007, Peer-reviewed

  
• Novel histidine-conjugated galactosylated cationic liposomes for efficient hepatocyte-selective gene transfer in human hepatoma HepG2 cells

  Kosuke Shigeta; Shigeru Kawakami; Yuriko Higuchi; Tatsuya Okuda; Hiroko Yagi; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Apr. 2007, Peer-reviewed

  
• Quantitative acid hydrolysis of DE-310, a macromolecular carrier system for the camptothecin analog DX-8951f

  Yoshinobu Shiose; Hiroshi Kuga; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Mar. 2007, Peer-reviewed

  
• メカニカルマッサージによる腎臓選択的遺伝子導入

  向井 英史; 川上 茂; 山下 富義; 橋田 充

  日本薬学会年会要旨集, Mar. 2007, Peer-reviewed

  
• Analysis of in vivo nuclear factor-kappa B activation during liver inflammation in mice: Prevention by catalase delivery

  Kenji Hyoudou; Makiya Nishikawa; Yuki Kobayashi; Yukari Kuramoto; Fumiyoshi Yamashita; Mitsuru Hashida

  MOLECULAR PHARMACOLOGY, Feb. 2007, Peer-reviewed

  
• The potential role of fucosylated cationic liposome/NF kappa B decoy complexes in the treatment of cytokine-related liver disease

  Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOMATERIALS, Jan. 2007, Peer-reviewed

  
• IN SILICO KNOWLEDGE ACQUISITION AND DATA MINING IN THE CYP-CHEMICAL INTERACTION STUDIES

  Fumiyoshi Yamashita

  DRUG METABOLISM REVIEWS, 2007, Peer-reviewed

  
• TARGETING OF DEXAMETHASONE PALMITATE INCORPORATED IN MANNOSYLATED LIPOSOMES TO ALVEOLAR MACROPHAGES AMELIORATES LUNG INFLAMMATION IN MURINE MODEL

  Wassana Wijagkanalan; Shigeru Kawakami; Fumiyoshi Yamashita; Hitoshi Sasaki; Mitsuru Hashida

  DRUG METABOLISM REVIEWS, 2007, Peer-reviewed

  
• INHIBITORY EFFECT OF MANNOSYLATED CATIONIC LIPOSOME/NF kappa DECOY COMPLEXES ON CYTOKINE PRODUCTION IN LPS-INDUCED SEPTIC PERITONITIS MOUSE MODEL

  Thuy Duong Dinh; Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  DRUG METABOLISM REVIEWS, 2007, Peer-reviewed

  
• LARGE-SCALE EXPLORATION OF INTESTINAL PHYSIOLOGICAL PARAMETERS IN SIMULATING ORAL ABSORPTION OF CANDIDATE COMPOUNDS IN RATS

  Keisuke Terashima; Chiaki Oka; Nobuaki Sarai; Fumiyoshi Yamashita

  DRUG METABOLISM REVIEWS, 2007, Peer-reviewed

  
• ANALYSIS OF STRUCTURE-ACTIVITY RELATIONSHIP OF ORAL BIOAVAILABILITY USING RECURSIVE PARTITIONING METHOD

  Hideto Hara; Fumiyoshi Yamashita; Mitsuru Hashida

  DRUG METABOLISM REVIEWS, 2007, Peer-reviewed

  
• PEGylated lysine dendrimers for tumor-selective targeting after intravenous injection in tumor-bearing mice

  Tatsuya Okuda; Shigeru Kawakami; Naomi Akimoto; Takuro Niidome; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Dec. 2006, Peer-reviewed

  
• Inhibition of pulmonary metastasis in mice by all-trans retinoic acid incorporated in cationic liposomes

  Sachiko Suzuki; Shigeru Kawakami; Narin Chansri; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Nov. 2006, Peer-reviewed

  
• Inhibition of adhesion and proliferation of peritoneally disseminated tumor cells by pegylated catalase

  Kenji Hyoudou; Makiya Nishikawa; Yuki Kobayashi; Yukari Kuramoto; Fumiyoshi Yamashita; Mitsuru Hashida

  CLINICAL & EXPERIMENTAL METASTASIS, Nov. 2006, Peer-reviewed

  
• PEGylated catalase prevents metastatic tumor growth aggravated by tumor removal

  Kenji Hyoudou; Makiya Nishikawa; Yuki Kobayashi; Yukari Umeyama; Fumiyoshi Yamashita; Mitsuru Hashida

  FREE RADICAL BIOLOGY AND MEDICINE, Nov. 2006, Peer-reviewed

  
• Inhibition of peritoneal dissemination of tumor cells by single dosing of phosphodiester CpG oligonucleotide/cationic liposome complex

  Yukari Kuramoto; Makiya Nishikawa; Kenji Hyoudou; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Oct. 2006, Peer-reviewed

  
• Basic fibroblast growth factor-binding peptide as a novel targeting ligand of drug carrier to tumor cells

  Takeshi Terada; Miki Mizobata; Shigeru Kawakami; Yoshiyuki Yabe; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF DRUG TARGETING, Sep. 2006, Peer-reviewed

  
• Intracellular trafficking is the important process that determines the optimal charge ratio on transfection by galactosylated lipoplex in HepG2 cells

  Yasunori Saito; Shigeru Kawakami; Yoshiyuki Yabe; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Sep. 2006, Peer-reviewed

  
• Role of tyrosine and tryptophan in chemically modified serum albumin on its tissue distribution

  Shen-Feng Ma; Makiya Nishikawa; Yoshiyuki Yabe; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Sep. 2006, Peer-reviewed

  
• Inhibition of liver metastasis by all-trans retinoic acid incorporated into O/W emulsions in mice

  Narin Chansri; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Sep. 2006, Peer-reviewed

  
• Levels and concentration ratios of polychlorinated biphenyls and polybrominated diphenyl ethers in serum and breast milk in Japanese mothers

  Kayoko Inoue; Kouji Harada; Katsunobu Takenaka; Shigeki Uehara; Makoto Kono; Takashi Shimizu; Takumi Takasuga; Kurunthachalam Senthilkumar; Fumiyoshi Yamashita; Akio Koizumi

  ENVIRONMENTAL HEALTH PERSPECTIVES, Aug. 2006, Peer-reviewed

  
• Effect of mannose density on mannose receptor-mediated cellular uptake of mannosylated O/W emulsions by macrophages

  Wassana Yeeprae; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Aug. 2006, Peer-reviewed

  
• Biodistribution characteristics of amino acid dendrimers and their PEGylated derivatives after intravenous administration

  Tatsuya Okuda; Shigeru Kawakami; Tadahiro Maeie; Takuro Niidome; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Aug. 2006, Peer-reviewed

  
• Efficient gene transfer into macrophages and dendritic cells by in vivo gene delivery with mannosylated lipoplex via the intraperitoneal route

  Yoshiyuki Hattori; Shigeru Kawakami; Kazumi Nakamura; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Aug. 2006, Peer-reviewed

  
• Enhanced DNA vaccine potency by mannosytated lipoplex after intraperitoneal administration

  Yoshiyuki Hattori; Shigeru Kawakami; Yan Lu; Kazumi Nakamura; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF GENE MEDICINE, Jul. 2006, Peer-reviewed

  
• Effect of the particle size of galactosylated lipoplex on hepatocyte-selective gene transfection after intraportal administration

  Yuriko Higuchi; Shigeru Kawakami; Shintaro Fumoto; Furniyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jul. 2006, Peer-reviewed

  
• Intravenous administration of mannosylated cationic liposome/NF kappa B decoy complexes effectively prevent LPS-induced cytokine production in a murine liver failure model

  Y Higuchi; S Kawakami; M Oka; Y Yabe; F Yamashita; M Hashida

  FEBS LETTERS, Jun. 2006, Peer-reviewed

  
• Evaluation of proinflammatory cytokine production induced by linear and branched polyethylenimine/plasmid DNA complexes in mice

  S Kawakami; Y Ito; P Charoensit; F Yamashita; M Hashida

  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Jun. 2006, Peer-reviewed

  
• Analysis of the molecular interaction between mannosylated proteins and serum mannan-binding lectins

  T Terada; M Nishikawa; F Yamashita; M Hashida

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Jun. 2006, Peer-reviewed

  
• Analysis of the molecular interaction of glycosylated proteins with rabbit liver asialoglycoprotein receptors using surface plasmon resonance spectroscopy

  T Terada; M Nishikawa; F Yamashita; M Hashida

  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, Jun. 2006, Peer-reviewed

  
• Visualization of large-scale aqueous solubility data using a novel hierarchical data visualization technique

  Fumiyoshi Yamashita; Takayuki Itoh; Hideto Hara; Mitsuru Hashida

  JOURNAL OF CHEMICAL INFORMATION AND MODELING, May 2006, Peer-reviewed

  
• Erratum: Intracellular distribution of NFκB decoy and its inhibitory effect on TNFα production by LPS stimulated RAW 264.7 cells (Journal of Controlled Release (2005) 107 (373-382) DOI: 10.1016/j.jconrel.2005.07.004)

  Yuriko Higuchi; Shigeru Kawakami; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida

  Journal of Controlled Release, 10 Apr. 2006, Peer-reviewed

  
• Influence of cholesterol composition on the association of serum mannan-binding proteins with mannosylated liposomes

  T Terada; M Nishikawa; F Yamashita; M Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Apr. 2006, Peer-reviewed

  
• Novel PEG-matrix metalloproteinase-2 cleavable peptide-lipid containing galactosylated liposomes for hepatocellular carcinoma-selective targeting

  T Terada; M Iwai; S Kawakami; F Yamashita; M Hashida

  JOURNAL OF CONTROLLED RELEASE, Apr. 2006, Peer-reviewed

  
• Intracellular distribution of NF kappa B decoy and its inhibitory effect on TNF alpha production by LPS stimulated RAW 264.7 cells (vol 107, pg 373, 2005)

  Y Higuchi; S Kawakami; M Nishikawa; F Yamashita; M Hashida

  JOURNAL OF CONTROLLED RELEASE, Apr. 2006, Peer-reviewed

  
• Improved anti-oxidant activity of superoxide dismutase by direct chemical modification

  N Ishimoto; T Nemoto; K Nagayoshi; F Yamashita; M Hashida

  JOURNAL OF CONTROLLED RELEASE, Mar. 2006, Peer-reviewed

  
• Suppression of TNF alpha production in LPS induced liver failure in mice after intravenous injection of cationic liposomes/NF kappa B decoy complex

  Y Higuchi; S Kawakami; M Oka; F Yamashita; M Hashida

  PHARMAZIE, Feb. 2006, Peer-reviewed

  
• Physicochemical and pharmacokinetic characteristics of cationic liposomes

  W Yeeprae; S Kawakami; S Suzuki; F Yamashita; M Hashida

  PHARMAZIE, Feb. 2006, Peer-reviewed

  
• Induction of apoptosis in A549 human lung cancer cells by all-trans retinoic acid incorporated in DOTAP/cholesterol liposomes

  S Kawakami; S Suzuki; F Yamashita; M Hashida

  JOURNAL OF CONTROLLED RELEASE, Feb. 2006, Peer-reviewed

  
• Use of lipoplex-induced nuclear factor-kappa B activation to enhance transgene expression by lipoplex in mouse tung

  T Kuramoto; M Nishikawa; O Thanaketpaisarn; T Okabe; F Yamashita; M Hashida

  JOURNAL OF GENE MEDICINE, Jan. 2006, Peer-reviewed

  
• Liver targeting of catalase by cationization for prevention of acute liver failure in mice

  SF Ma; M Nishikawa; H Katsumi; F Yamashita; M Hashida

  JOURNAL OF CONTROLLED RELEASE, Jan. 2006, Peer-reviewed

  
• Quantitative structure/activity relationship modelling of pharmacokinetic properties using genetic algorithm-combined partial least squares method

  Fumiyoshi Yamashita; Shin-Ichi Fujiwara; Suchada Wanchana; Mitsuru Hashida

  JOURNAL OF DRUG TARGETING, 2006, Peer-reviewed

  
• Biodistribution characteristics of all-trans retinoic acid incorporated in liposomes and polymeric micelles following intravenous administration

  S Kawakami; P Opanasopit; M Yokoyama; N Chansri; T Yamamoto; T Okano; F Yamashita; M Hashida

  JOURNAL OF PHARMACEUTICAL SCIENCES, Dec. 2005, Peer-reviewed

  
• Enhanced gene expression in lung by a stabilized lipoplex using sodium chloride for complex formation

  S Kawakami; Y Ito; S Fumoto; F Yamashita; M Hashida

  JOURNAL OF GENE MEDICINE, Dec. 2005, Peer-reviewed

  
• The role of dioleoylphosphaticlylethanolamine (DOPE) in targeted gene delivery with mannosylated cationic liposomes via intravenous route

  Y Hattori; S Suzuki; S Kawakami; F Yamashita; M Hashida

  JOURNAL OF CONTROLLED RELEASE, Nov. 2005, Peer-reviewed

  
• Interaction with blood components plays a crucial role in asialoglycoprotein receptor-mediated in vivo gene transfer by galactosylated lipoplex

  S Fumoto; S Kawakami; K Shigeta; Y Higuchi; F Yamashita; M Hashida

  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Nov. 2005, Peer-reviewed

  
• The role of dioleoylphosphatidylethanolamine (DOPE) for targeted in vivo gene transfer to liver non-parenchymal cells following intravenous administration of mannosylated cationic liposomes

  Yoshiyuki Hattori; Sachiko Suzuki; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  Journal of Controlled Release, Nov. 2005, Peer-reviewed

  
• Estimation of in vivo percutaneous absorption of emedastine from bile excretion data using a deconvolution method.

  Harada, S.; Yamashita, F.; Hashida, M.

  Drug metabolism and pharmacokinetics, Oct. 2005, Peer-reviewed

  
• Effect of galactose density on asialoglycoprotein receptor-mediated uptake of galactosylated liposomes

  C Managit; S Kawakami; F Yamashita; M Hashida

  JOURNAL OF PHARMACEUTICAL SCIENCES, Oct. 2005, Peer-reviewed

  
• Intracellular distribution of NF kappa B decoy and its inhibitory effect on TNF alpha production by LPS stimulated RAW 264.7 cells

  Y Higuchi; S Kawakami; M Nishikawa; F Yamashita; M Hashida

  JOURNAL OF CONTROLLED RELEASE, Oct. 2005, Peer-reviewed

  
• Biodistribution characteristics of mannosylated and fucosylated O/W emulsions in mice

  W Yeeprae; S Kawakami; Y Higuchi; F Yamashita; M Hashida

  JOURNAL OF DRUG TARGETING, Sep. 2005, Peer-reviewed

  
• Effect of low-molecular-weight beta-cyclodextrin polymer on release of drugs from mucoadhesive buccal film dosage forms

  Y Arakawa; S Kawakami; F Yamashita; M Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Sep. 2005, Peer-reviewed

  
• Uptake characteristics of galactosylated emulsion by HepG2 hepatoma cells

  C Managit; S Kawakami; F Yamashita; M Hashida

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Sep. 2005, Peer-reviewed

  
• Development of polyethylene glycol-conjugated poly-S-nitrosated serum albumin, a novel S-nitrosothiol for prolonged delivery of nitric oxide in the blood circulation in vivo

  H Katsumi; M Nishikawa; F Yamashita; M Hashida

  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Sep. 2005, Peer-reviewed

  
• Lipid carrier systems for targeted drug and gene delivery

  M Hashida; S Kawakami; F Yamashita

  CHEMICAL & PHARMACEUTICAL BULLETIN, Aug. 2005, Peer-reviewed

  
• Tissue-specific characteristics of in vivo electric gene: Transfer by tissue and intravenous injection of plasmid DNA

  O Thanaketpaisarn; M Nishikawa; F Yamashita; M Hashida

  PHARMACEUTICAL RESEARCH, Jun. 2005, Peer-reviewed

  
• Hepatocyte-targeted gene transfer by combination of vascularly delivered plasmid DNA and in vivo electroporation

  M Sakai; M Nishikawa; O Thanaketpaisarn; F Yamashita; M Hashida

  GENE THERAPY, Apr. 2005, Peer-reviewed

  
• Cationic charge-dependent hepatic delivery of amidated serum albumin

  SF Ma; M Nishikawa; H Katsumi; F Yamashita; M Hashida

  JOURNAL OF CONTROLLED RELEASE, Feb. 2005, Peer-reviewed

  
• Biopharmaceutical considerations on antihistamine effects of topically administered emedastine

  S Harada; Y Nakada; F Yamashita; M Hashida

  JOURNAL OF PHARMACEUTICAL SCIENCES, Jan. 2005, Peer-reviewed

  
• Cell-selective delivery of gene and nucleic acid using glycosylated cationic liposomes

  S. Kawakami; F. Yamashita; M. Hashida

  Polymer Preprints, Japan, 2005, Peer-reviewed

  
• Two- and three-dimensional QSAR of carrier-mediated transport of beta-lactam antibiotics in Caco-2 cells

  S Wanchana; F Yamashita; H Hara; SI Fujiwara; M Akamatsu; M Hashida

  JOURNAL OF PHARMACEUTICAL SCIENCES, Dec. 2004, Peer-reviewed

  
• Effect of polycyclic aromatic hydrocarbons on generation and efflux of glutathione conjugates in primary cultured alveolar epithelial cells.

  K. Nagayoshi; T. Nemoto; S. Yokoyama; F. Yamashita; M. Hashida

  Drug metabolism and pharmacokinetics, Dec. 2004, Peer-reviewed

  
• Uptake characteristics of mannosylated and fucosylated bovine serum albumin in primary cultured rat sinusoidal endothelial cells and Kupffer cells

  Y Higuchi; M Nishikawa; S Kawakami; F Yamashita; M Hashida

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Dec. 2004, Peer-reviewed

  
• Inhibition of metastatic tumor growth in mouse lung by repeated administration of polyethylene glycol-conjugated catalase: Quantitative analysis with firefly luciferase-expressing melanoma cells

  K Hyoudou; M Nishikawa; Y Umeyama; Y Kobayashi; F Yamashita; M Hashida

  CLINICAL CANCER RESEARCH, Nov. 2004, Peer-reviewed

  
• In silico approaches for predicting ADME properties of drugs.

  F. Yamashita; M. Hashida

  Drug metabolism and pharmacokinetics, Oct. 2004, Peer-reviewed

  
• Enhanced hepatocyte-selective in vivo gene expression by stabilized galactosylated liposome/plasmid DNA complex using sodium chloride for complex formation

  S Fumoto; S Kawakami; Y Ito; K Shigeta; F Yamashita; M Hashida

  MOLECULAR THERAPY, Oct. 2004, Peer-reviewed

  
• Physicochemical, tissue distribution, and vasodilation characteristics of nitrosated serum albumin: Delivery of nitric oxide in vivo

  H Katsumi; M Nishikawa; SF Ma; F Yamashita; M Hashida

  JOURNAL OF PHARMACEUTICAL SCIENCES, Sep. 2004, Peer-reviewed

  
• Exogenous expression of interferon-beta in cultured brain microvessel endothelial cells

  M Nakamura; S Yamaguchi; Y Watanabe; F Yamashita; Y Takakura; M Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Sep. 2004, Peer-reviewed

  
• Tissue and intrahepatic distribution and subcellular localization of a mannosylated lipoplex after intravenous administration in mice

  M Yamada; M Nishikawa; S Kawakami; Y Hattori; T Nakano; F Yamashita; M Hashida

  JOURNAL OF CONTROLLED RELEASE, Jul. 2004, Peer-reviewed

  
• Biodistribution characteristics of galactosylated emulsions and incorporated probucol for hepatocyte-selective targeting of lipophilic drugs in mice

  E Ishida; C Managit; S Kawakami; M Nishikawa; F Yamashita; M Hashida

  PHARMACEUTICAL RESEARCH, Jun. 2004, Peer-reviewed

  
• Effect of cationic charge on receptor-mediated transfection using mannosylated cationic liposome/plasmid DNA complexes following the intravenous administration in mice

  S Kawakami; Y Hattori; Y Lu; Y Higuchi; F Yamashita; M Hashida

  PHARMAZIE, May 2004, Peer-reviewed

  
• Enhancement of immune responses by DNA vaccination through targeted gene delivery using mannosylated cationic liposome formulations following intravenous administration in mice

  Y Hattori; S Kawakami; S Suzuki; F Yamashita; M Hashida

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2004, Peer-reviewed

  
• Expression and visualization of a human interferon-beta-enhanced green fluorescent protein chimeric molecule in cultured cells

  M Nakamura; M Maruyama; F Yamashita; Y Takakura; M Hashida; Y Watanabe

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Mar. 2004, Peer-reviewed

  
• Inhibition of experimental hepatic metastasis by targeted delivery of catalase in mice

  M Nishikawa; A Tamada; K Hyoudou; Y Umeyama; Y Takahashi; Y Kobayashi; H Kumai; E Ishida; F Staud; Y Yabe; Y Takakura; F Yamashita; M Hashida

  CLINICAL & EXPERIMENTAL METASTASIS, 2004, Peer-reviewed

  
• Targeted and sustained drug delivery using PEGylated galactosylated liposomes

  C Managit; S Kawakami; M Nishikawa; F Yamashita; M Hashida

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Nov. 2003, Peer-reviewed

  
• QSAR analysis of interstudy variable skin permeability based on the "latent membrane permeability" concept

  SI Fujiwara; F Yamashita; M Hashida

  JOURNAL OF PHARMACEUTICAL SCIENCES, Oct. 2003, Peer-reviewed

  
• Residualizing indium-111-radiolabel for plasmid DNA and its application to tissue distribution study

  M Nishikawa; T Nakano; T Okabe; N Hamaguchi; Y Yamasaki; Y Takakura; F Yamashita; M Hashida

  BIOCONJUGATE CHEMISTRY, Sep. 2003, Peer-reviewed

  
• Analysis of hepatic disposition of galactosylated cationic liposome/plasmid DNA complexes in perfused rat liver

  S Fumoto; F Nakadori; S Kawakami; M Nishikawa; F Yamashita; M Hashida

  PHARMACEUTICAL RESEARCH, Sep. 2003, Peer-reviewed

  
• QSAR analysis of the inhibition of recombinant CYP 3A4 activity by structurally diverse compounds using a genetic algorithm-combined partial least squares method

  S Wanchana; F Yamashita; M Hashida

  PHARMACEUTICAL RESEARCH, Sep. 2003, Peer-reviewed

  
• Therapeutic effect of intravenous delivery of lipoplexes containing the interferon-beta gene and poly I : poly C in a murine lung metastasis model

  F Sakurai; T Terada; M Maruyama; Y Watanabe; F Yamashita; Y Takakura; M Hashida

  CANCER GENE THERAPY, Sep. 2003, Peer-reviewed

  
• Mechanistic and empirical modeling of skin permeation of drugs

  F Yamashita; M Hashida

  ADVANCED DRUG DELIVERY REVIEWS, Sep. 2003, Peer-reviewed

  
• Artificial neural network modeling for pharmaceutical research

  F Yamashita; K Takayama

  ADVANCED DRUG DELIVERY REVIEWS, Sep. 2003, Peer-reviewed

  
• Determination of matrine in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies

  XN Wu; F Yamasita; M Hashida; XG Chen; ZD Hu

  TALANTA, Apr. 2003, Peer-reviewed

  
• Molecular weight-dependent gene transfection activity of unmodified and galactosylated polyethyleneimine on hepatoma cells and mouse liver

  K Morimoto; M Nishikawa; S Kawakami; T Nakano; Y Hattori; S Fumoto; F Yamashita; M Hashida

  MOLECULAR THERAPY, Feb. 2003, Peer-reviewed

  
• Control of hepatic disposition of mannosylated liposomes by PEGylation: effect of the molecular weight of PEG and the density of PEG and mannose

  P Opanasopit; M Nishikawa; C Managit; F Yamashita; M Hashida

  STP PHARMA SCIENCES, Jan. 2003, Peer-reviewed

  
• Glycosylated Cationic Liposomes for Carbohydrate Receptor-Mediated Gene Transfer

  Makiya Nishikawa; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  LIPOSOMES, PT C, 2003, Peer-reviewed

  
• In silico prediction and control of ADME properties

  Fumiyoshi Yamashita; Mitsuru Hashida

  Drug Delivery System, 2003, Peer-reviewed

  
• Analysis of Hepatic Disposition of Native and Galactosylated Polyethylenimine Complexed with Plasmid DNA in Perfused Rat Liver

  Shintaro Fumoto; Shigeru Kawakami; Masako Ishizuka; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida

  Drug Metabolism and Pharmacokinetics, 2003, Peer-reviewed

  
• Pharmacokinetics and preventive effects of targeted catalase derivatives on hydrogen peroxide-induced injury in perfused rat liver

  Y Yabe; N Kobayashi; M Nishikawa; K Mihara; F Yamashita; Y Takakura; M Hashida

  PHARMACEUTICAL RESEARCH, Dec. 2002, Peer-reviewed

  
• Targeting efficiency of galactosylated liposomes to hepatocytes in vivo: Effect of lipid composition

  A Murao; M Nishikawa; C Managit; J Wong; S Kawakami; F Yamashita; M Hashida

  PHARMACEUTICAL RESEARCH, Dec. 2002, Peer-reviewed

  
• Quantitative structure/property relationship analysis of Caco-2 permeability using a genetic algorithm-based partial least squares method

  F Yamashita; S Wanchana; M Hashida

  JOURNAL OF PHARMACEUTICAL SCIENCES, Oct. 2002, Peer-reviewed

  
• The role of tissue macrophages in the induction of proinflammatory cytokine production following intravenous injection of lipoplexes

  F Sakurai; T Terada; K Yasuda; F Yamashita; Y Takakura; M Hashida

  GENE THERAPY, Aug. 2002, Peer-reviewed

  
• Secretion polarity of interferon-beta in epithelial cell lines

  K Nakanishi; Y Watanabe; M Maruyama; F Yamashita; Y Takakura; M Hashida

  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Jun. 2002, Peer-reviewed

  
• Inhibition of experimental pulmonary metastasis by controlling biodistribution of catalase in mice

  M Nishikawa; A Tamada; H Kumai; F Yamashita; M Hashida

  INTERNATIONAL JOURNAL OF CANCER, May 2002, Peer-reviewed

  
• Pharmacokinetic analysis of in vivo disposition of succinylated proteins targeted to liver nonparenchymal cells via scavenger receptors: Importance of molecular size and negative charge density for in vivo recognition by receptors

  Y Yamasaki; K Sumimoto; M Nishikawa; F Yamashita; K Yamaoka; M Hashida; Y Takakura

  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, May 2002, Peer-reviewed

  
• Inhibition of liver metastasis by targeting of immunomodulators using mannosylated liposome carriers

  P Opanasopit; M Sakai; M Nishikawa; S Kawakami; F Yamashita; M Hashida

  JOURNAL OF CONTROLLED RELEASE, Apr. 2002, Peer-reviewed

  
• Serum mannan binding protein inhibits mannosylated liposome-mediated transfection to macrophages

  P Opanasopit; K Hyoudou; M Nishikawa; F Yamashita; M Hashida

  BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Apr. 2002, Peer-reviewed

  
• Electrical charge on protein regulates its absorption from the rat small intestine

  M Nishikawa; S Hasegawa; F Yamashita; Y Takakura; M Hashida

  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, Apr. 2002, Peer-reviewed

  
• Prediction of Caco-2 cell permeability using a combination of MO-calculation and neural network

  S Fujiwara; F Yamashita; M Hashida

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Apr. 2002, Peer-reviewed

  
• Influence of physicochemical properties on pharmacokinetics of non-viral vectors for gene delivery

  Y Takakura; M Nishikawa; F Yamashita; M Hashida

  JOURNAL OF DRUG TARGETING, Mar. 2002, Peer-reviewed

  
• Prediction of human skin permeability using a combination of molecular orbital calculations and artificial neural network

  CW Lim; S Fujiwara; F Yamashita; M Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Mar. 2002, Peer-reviewed

  
• The "latent membrane permeability" concept: QSPR analysis of inter/intralaboratorically variable Caco-2 permeability

  F Yamashita; S Fujiwara; M Hashida

  JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, Mar. 2002, Peer-reviewed

  
• Quantitative structure/property relationship analysis on aqueous solubility using genetic algorithm-combined partial least squares method

  S Wanchana; F Yamashita; M Hashida

  PHARMAZIE, Feb. 2002, Peer-reviewed

  
• Glycosylated cationic Liposomes for cell-selective gene delivery

  S Kawakami; F Yamashita; K Nishida; J Nakamura; M Hashida

  CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, 2002, Peer-reviewed

  
• Cell-specific delivery of genes with glycosylated carriers

  M Hashida; M Nishikawa; F Yamashita; Y Takakura

  ADVANCED DRUG DELIVERY REVIEWS, Nov. 2001, Peer-reviewed

  
• Effects of erythrocytes and serum proteins on lung accumulation of lipoplexes containing cholesterol or DOPE as a helper lipid in the single-pass rat lung perfusion system

  F Sakurai; T Nishioka; F Yamashita; Y Takakura; M Hashida

  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, Sep. 2001, Peer-reviewed

  
• Transport characteristics of ebastine and its metabolites across human intestinal epithelial Caco-2 cell monolayers

  Y Imamura; K Shimizu; F Yamashita; K Yamaoka; Y Takakura; M Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Aug. 2001, Peer-reviewed

  
• Molecular and pharmacokinetic properties of 222 commercially available oral drugs in humans

  T Sakaeda; N Okamura; S Nagata; T Yagami; M Horinouchi; K Okumura; F Yamashita; M Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Aug. 2001, Peer-reviewed

  
• Interaction between DNA-cationic liposome complexes and erythrocytes is an important factor in systemic gene transfer via the intravenous route in mice: the role of the neutral helper lipid

  F Sakurai; T Nishioka; H Saito; T Baba; A Okuda; O Matsumoto; T Taga; F Yamashita; Y Takakura; M Hashida

  GENE THERAPY, May 2001, Peer-reviewed

  
• In vivo recognition of mannosylated proteins by hepatic mannose receptors and mannan-binding protein

  P Opanasopit; K Shirashi; M Nishikawa; F Yamashita; Y Takakura; M Hashida

  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, May 2001, Peer-reviewed

  
• Development of gene drug delivery systems based on pharmacokinetic studies

  Y Takakura; M Nishikawa; F Yamashita; M Hashida

  EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, Apr. 2001, Peer-reviewed

  
• Involvement of serum mannan binding proteins and mannose receptors in uptake of mannosylated liposomes by macrophages

  P Opanasopit; Y Higuchi; S Kawakami; F Yamashita; M Nishikawa; M Hashida

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Mar. 2001, Peer-reviewed

  
• Novel galactosylated liposomes for hepatocyte-selective targeting of lipophilic drugs

  S Kawakami; C Munakata; S Fumoto; F Yamashita; M Hashida

  JOURNAL OF PHARMACEUTICAL SCIENCES, Feb. 2001, Peer-reviewed

  
• The effect of lipid composition on receptor-mediated in vivo gene transfection using mannosylated cationic liposomes in mice

  S Kawakami; A Sato; M Yamada; F Yamashita; M Hashida

  STP PHARMA SCIENCES, Jan. 2001, Peer-reviewed

  
• Pharmacokinetic analysis of lectin-dependent biodistribution of fucosylated bovine serum albumin: A possible carrier for Kupffer cells

  P Opanasopit; M Nishikawa; F Yamashita; Y Takakura; N Hashida

  JOURNAL OF DRUG TARGETING, 2001, Peer-reviewed

  
• Enhanced gene transfection in macrophages using mannosylated cationic liposome-polyethylenimine-plasmid DNA complexes

  A Sato; S Kawakami; M Yamada; F Yamashita; M Hashida

  JOURNAL OF DRUG TARGETING, 2001, Peer-reviewed

  
• Biodistribution characteristics of mannosylated, fucosylated, and galactosylated liposomes in mice

  S Kawakami; J Wong; A Sato; Y Hattori; F Yamashita; M Hashida

  BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Dec. 2000, Peer-reviewed

  
• Disposition characteristics of emulsions and incorporated drugs after systemic or local injection

  S Kawakami; F Yamashita; M Hashida

  ADVANCED DRUG DELIVERY REVIEWS, Dec. 2000, Peer-reviewed

  
• Controlled biodistribution of galactosylated liposomes and incorporated probucol in hepatocyte-selective drug targeting

  Y Hattori; S Kawakami; F Yamashita; M Hashida

  JOURNAL OF CONTROLLED RELEASE, Dec. 2000, Peer-reviewed

  
• Erratum: Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression (Journal of Controlled Release 66 (2000) (255-269) PII: S0168365999002801)

  F. Sakurai; R. Inoue; Y. Nishino; A. Okuda; O. Matsumoto; T. Taga; F. Yamashita; Y. Takakura; M. Hashida

  Journal of Controlled Release, 03 Oct. 2000, Peer-reviewed

  
• Effect of vehicle properties on skin penetration of emedastine

  S Harada; Y Takahashi; H Nakagawa; F Yamashita; M Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Oct. 2000, Peer-reviewed

  
• Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression

  F Sakurai; R Inoue; Y Nishino; A Okuda; O Matsumoto; T Taga; F Yamashita; Y Takakura; M Hashida

  JOURNAL OF CONTROLLED RELEASE, May 2000, Peer-reviewed

  
• Intratumoral pharmacokinetics of oligonucleotides in a tissue-isolated tumor perfusion system

  S Nakajima; Y Koshino; T Nomura; F Yamashita; S Agrawal; Y Takakura; M Hashida

  ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, Apr. 2000, Peer-reviewed

  
• Design of polymeric prodrugs of PGE1 for cell-specific hepatic targeting

  M Hashida; K Akamatsu; M Nishikawa; F Yamashita; H Yoshikawa; Y Takakura

  PHARMAZIE, Mar. 2000, Peer-reviewed

  
• In vivo gene delivery to the liver using novel galactosylated cationic liposomes

  S Kawakami; S Fumoto; M Nishikawa; F Yamashita; M Hashida

  PHARMACEUTICAL RESEARCH, Mar. 2000, Peer-reviewed

  
• Mannose receptor-mediated gene transfer into macrophages using novel mannosylated cationic liposomes

  S Kawakami; A Sato; M Nishikawa; F Yamashita; M Hashida

  GENE THERAPY, Feb. 2000, Peer-reviewed

  
• RELATIONSHIP BETWEEN PHYSICOCHEMICAL CHARACTERISITCS, DISTRIBUTION OF DNA-CATIONIC LIPOSOME COMPLEXES AND THEIR GENE EXPRESSION, AND APPLICATION TO GENE THERAPY

  SAKURAI Fuminori; YAMASHITA Fumiyoshi; TAKAKURA Yoshinobu; HASHIDA Mitsuru

  Drug Metabolism and Pharmacokinetics, 2000

  
• Effect of cationic liposomes on intracellular trafficking and efficacy of antisense oligonucleotides in mouse peritoneal macrophages

  T Takagi; M Hashiguchi; T Hiramatsu; F Yamashita; Y Takakura; M Hashida

  JOURNAL OF DRUG TARGETING, 2000, Peer-reviewed

  
• Rates of protein transport across rat alveolar epithelial cell monolayers

  Y Matsukawa; H Yamahara; F Yamashita; VHL Lee; ED Crandall; KJ Kim

  JOURNAL OF DRUG TARGETING, 2000, Peer-reviewed

  
• Targeted delivery of prostaglandin E1 to hepatocytes using galactosylated liposomes

  S. Kawakami; C. Munakata; S. Fumoto; F. Yamashita; M. Hashida

  Journal of Drug Targeting, 2000, Peer-reviewed

  
• Pharmacokinetics and in vivo gene transfer of plasmid DNA complexed with mannosylated poly(L-lysine) in mice

  M Nishikawa; S Takemura; F Yamashita; Y Takakura; DKF Meijer; M Hashida; PJ Swart

  JOURNAL OF DRUG TARGETING, 2000, Peer-reviewed

  
• Design of polymeric prodrugs of prostaglandin E-1 having galactose residue for hepatocyte targeting

  M Hashida; K Akamatsu; M Nishikawa; F Yamashita; Y Takakura

  JOURNAL OF CONTROLLED RELEASE, Nov. 1999, Peer-reviewed

  
• Deconvolution analysis for absorption and metabolism of aspirin in microcapsules

  XN Wu; F Yamashita; M Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Nov. 1999, Peer-reviewed

  
• Pharmacokinetic analysis of I-123-labeled medium chain fatty acid as a radiopharmaceutical for hepatic function based on beta-oxidation

  N Yamamura; Y Magata; F Yamashita; M Hashida; H Saji

  ANNALS OF NUCLEAR MEDICINE, Aug. 1999, Peer-reviewed

  
• Organic cation transport in rabbit alveolar epithelial cell monolayers

  J Shen; KJ Elbert; F Yamashita; CM Lehr; KJ Kim; VHL Lee

  PHARMACEUTICAL RESEARCH, Aug. 1999, Peer-reviewed

  
• Characterization of plasmid DNA binding and uptake by peritoneal macrophages from class a scavenger receptor knockout mice

  Y Takakura; T Takagi; M Hashiguchi; M Nisihikawa; F Yamashita; T Doi; T Imanishi; H Suzuki; T Kodama; M Hashida

  PHARMACEUTICAL RESEARCH, Apr. 1999, Peer-reviewed

  
• Cell specific targeting of drugs and genes with glycosylated liposomes

  Mitsuru Hashida; Makiya Nishikawa; Fumiyoshi Yamashita; Yoshinobu Takakura

  American Chemical Society, Polymer Preprints, Division of Polymer Chemistry, Mar. 1999

  
• Theoretical analysis of the effect of cutaneous metabolism on skin permeation of parabens based on a two-layer skin diffusion/metabolism model

  N Seko; H Bando; CW Lim; F Yamashita; M Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Mar. 1999, Peer-reviewed

  
• Cell specific targeting of drugs and genes with glycosylated liposomes.

  M Hashida; M Nishikawa; F Yamashita; Y Takakura

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 1999, Peer-reviewed

  
• Stimulation side-dependent asymmetrical secretion of poly I : poly C-induced interferon-beta from polarized epithelial cell lines

  S Okamoto; K Nakanishi; Y Watanabe; F Yamashita; Y Takakura; M Hashida

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 1999, Peer-reviewed

  
• Liver Cell-Selective Targeting Using Glycosylated Liposomes

  Kawakami Shigeru; Nishikawa Makiya; Yamashita Fumiyoshi; Hashida Mitsuru

  Drug Metabolism and Pharmacokinetics, 1999

  
• Asialoglycoprotein receptor-mediated gene transfer using novel galactosylated cationic liposomes

  S Kawakami; F Yamashita; M Nishikawa; Y Takakura; M Hashida

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 1998, Peer-reviewed

  
• Dipeptide uptake and transport characteristics in rabbit tracheal epithelial cell layers cultured at an air interface

  F Yamashita; KJ Kim; VHL Lee

  PHARMACEUTICAL RESEARCH, Jul. 1998, Peer-reviewed

  
• Control of plasma cholesterol-lowering action of probucol with various lipid carrier systems

  T Takino; N Koreeda; T Nomura; T Sakaeda; F Yamashita; Y Takakura; M Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, May 1998, Peer-reviewed

  
• Pharmacokinetic characteristics and therapeutic effects of mitomycin C dextran conjugates after intratumoural injection

  T Nomura; A Saikawa; S Morita; T Sakaeda; F Yamashita; K Honda; Y Takakura; M Hashida

  JOURNAL OF CONTROLLED RELEASE, Mar. 1998, Peer-reviewed

  
• Effect of particle size and charge on the disposition of lipid carriers after intratumoral injection into tissue-isolated tumors

  T Nomura; N Koreeda; F Yamashita; Y Takakura; M Hashida

  PHARMACEUTICAL RESEARCH, Jan. 1998, Peer-reviewed

  
• The effect of cutaneous metabolism on skin permeation of drugs: Analysis based on a diffusion/metabolism model

  Lim Chee Wooi; Fumiyoshi Yamashita; Yosinobu Takakura; Mitsuru Hasida

  Drug Delivery System, 1998, Peer-reviewed

  
• ドラッグデリバリーシステム (DDS) : この1年の進歩

  山下 富義; 橋田 充

  人工臓器, 15 Dec. 1997

  
• Intratumoral pharmacokinetics and in vivo gene expression of naked plasmid DNA and its cationic liposome complexes after direct gene transfer

  T Nomura; S Nakajima; K Kawabata; F Yamashita; Y Takakura; M Hashida

  CANCER RESEARCH, Jul. 1997, Peer-reviewed

  
• Effects of skin metabolism on percutaneous penetration of lipophilic drugs

  H Bando; S Mohri; F Yamashita; Y Takakura; M HAshida

  JOURNAL OF PHARMACEUTICAL SCIENCES, Jun. 1997, Peer-reviewed

  
• Pharmacokinetic analysis of scavenger receptor-mediated uptake of anionized proteins in the isolated perfused rat liver

  H Furitsu; K Ogawara; T Fujita; F Yamashita; Y Takakura; H Sezaki; M Hashida

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, May 1997, Peer-reviewed

  
• Gly-L-Phe transport and metabolism across primary cultured rabbit tracheal epithelial cell monolayers

  F Yamashita; KJ Kim; VHL Lee

  PHARMACEUTICAL RESEARCH, Feb. 1997, Peer-reviewed

  
• In vivo evaluation of acyclovir prodrug penetration and metabolism through rat skin using a diffusion/bioconversion model

  H Bando; M Sahashi; F Yamashita; Y Takakura; M Hashida

  PHARMACEUTICAL RESEARCH, Jan. 1997, Peer-reviewed

  
• Estimation of drug concentration profiles in skin based on a skin diffusion model

  Noritaka Seko; Hiroto Bando; Fumiyoshi Yamashita; Yoshinobu Takakura; Mitsuru Hashida

  Drug Delivery System, 1997, Peer-reviewed

  
• In vivo skin penetration enhancement of acyclovir by theoretical design of prodrug-enhancer combination

  H Bando; M Sahashi; S Mohri; F Yamashita; Y Takakura; M Hashida

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Dec. 1996, Peer-reviewed

  
• Respiratory epithelial cell culture models for evaluation of ion and drug transport

  NR Mathias; F Yamashita; VHL Lee

  ADVANCED DRUG DELIVERY REVIEWS, Nov. 1996, Peer-reviewed

  
• Pharmacokinetic analysis of drug disposition after intratumoral injection in a tissue-isolated tumor perfusion system

  A Saikawa; T Nomura; F Yamashita; Y Takakura; H Sezaki; M Hashida

  PHARMACEUTICAL RESEARCH, Oct. 1996, Peer-reviewed

  
• Analysis of in vitro skin penetration of acyclovir prodrugs based on a diffusion model with a metabolic process

  H Bando; M Sahashi; T Takagi; F Yamashita; Y Takakura; M Hashida

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Jun. 1996, Peer-reviewed

  
• Theoretical design of prodrug-enhancer combination based on a skin diffusion model: Prediction of permeation of acyclovir prodrugs treated with 1-geranylazacycloheptan-2-one

  H Bando; T Takagi; F Yamashita; Y Takakura; M Hashida

  PHARMACEUTICAL RESEARCH, Mar. 1996, Peer-reviewed

  
• Dipeptide transport characteristics of rabbit tracheal epithelial cell monolayers cultured at an air-interface

  F Yamashita; KJ Kim; VHL Lee

  23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, Peer-reviewed

  
• Biliary excretion of polystyrene microspheres with covalently linked FITC fluorescence after oral and parenteral administration to male Wistar rats

  PU Jani; T Nomura; F Yamashita; Y Takakura; AT Florence; M Hashida

  JOURNAL OF DRUG TARGETING, 1996, Peer-reviewed

  
• Theoretical design of skin penetration enhancement via prodrug-enhancer combination based on a diffusion model

  H Bando; F Yamashita; Y Takakura; M Hashida

  ADVANCED BIOMATERIALS IN BIOMEDICAL ENGINEERING AND DRUG DELIVERY SYSTEMS, 1996, Peer-reviewed

  
• A deconvolution method for estimating the first-pass metabolism of orally administered drugs

  F Yamashita; H Bando; Y Takakura; M Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Dec. 1995, Peer-reviewed

  
• GALACTOSYLATED PROTEINS ARE RECOGNIZED BY THE LIVER ACCORDING TO THE SURFACE-DENSITY OF GALACTOSE MOIETIES

  M NISHIKAWA; C MIYAZAKI; F YAMASHITA; Y TAKAKURA; M HASHIDA

  AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, May 1995, Peer-reviewed

  
• ANALYSIS OF IN-VIVO SKIN PENETRATION ENHANCEMENT BY OLEIC-ACID BASED ON A 2-LAYER DIFFUSION-MODEL WITH POLAR AND NONPOLAR ROUTES IN THE STRATUM-CORNEUM

  F YAMASHITA; Y KOYAMA; M KITANO; Y TAKAKURA; M HASHIDA

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Apr. 1995, Peer-reviewed

  
• PHARMACOKINETIC DISPOSITION ANALYSIS OF LIPOPHILIC DRUGS INJECTED WITH VARIOUS LIPID CARRIERS IN THE SINGLE-PASS RAT-LIVER PERFUSION SYSTEM

  T TAKINO; E NAGAHAMA; T SAKAEDA; F YAMASHITA; Y TAKAKURA; M HASHIDA

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Jan. 1995, Peer-reviewed

  
• Biliary excretion of polystyrene microspheres after oral and parenteral administration to rats

  P. U. Jani; F. Yamashita; T. Nomura; Y. Takakura; A. T. Florence; M. Hashida

  Proceedings of the Controlled Release Society, 1995

  
• Biodistribution control of lipophilic drugs with lipid carrier system

  Toichi Takino; Noriko Koreeda; Fumiyoshi Yamashita; Yoshinobu Takakura; Mitsuru Hashida

  Drug Delivery System, 1995, Peer-reviewed

  
• COMPARATIVE-ANALYSIS OF PERCUTANEOUS-ABSORPTION ENHANCEMENT BY D-LIMONENE AND OLEIC-ACID BASED ON A SKIN DIFFUSION-MODEL

  Y KOYAMA; H BANDO; F YAMASHITA; Y TAKAKURA; H SEZAKI; M HASHIDA

  PHARMACEUTICAL RESEARCH, Mar. 1994, Peer-reviewed

  
• IN-VIVO AND IN-VITRO ANALYSIS OF SKIN PENETRATION ENHANCEMENT BASED ON A 2-LAYER DIFFUSION-MODEL WITH POLAR AND NONPOLAR ROUTES IN THE STRATUM-CORNEUM

  F YAMASHITA; H BANDO; Y KOYAMA; S KITAGAWA; Y TAKAKURA; M HASHIDA

  PHARMACEUTICAL RESEARCH, Feb. 1994, Peer-reviewed

  
• HEPATIC DISPOSITION CONTROL OF LIPOPHILIC DRUGS VIA LIPID CARRIER SYSYTEMS

  TAKINO Toichi; YAMASHITA Fumiyoshi; TAKAKURA Yoshinobu; HASHIDA Mitsuru

  Drug Metabolism and Pharmacokinetics, 1994

  
• TARGETING DELIVERY OF PROTEIN DRUGS BY CHEMICAL MODIFICATION

  M HASHIDA; M NISHIKAWA; F YAMASHITA; Y TAKAKURA

  DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1994, Peer-reviewed

  
• ANALYSIS OF SKIN PENETRATION ENHANCEMENT BASED ON A 2-LAYER SKIN DIFFUSION-MODEL WITH POLAR AND NONPOLAR ROUTES IN THE STRATUM-CORNEUM - DOSE-DEPENDENT EFFECT OF 1-GERANYLAZACYCLOHEPTAN-2-ONE ON DRUGS WITH DIFFERENT LIPOPHILICITIES

  F YAMASHITA; T YOSHIOKA; Y KOYAMA; H OKAMOTO; H SEZAKI; M HASHIDA

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jul. 1993, Peer-reviewed

  
• ESTIMATION OF A CONCENTRATION PROFILE OF ACYCLOVIR IN THE SKIN AFTER TOPICAL ADMINISTRATION

  F YAMASHITA; Y KOYAMA; H SEZAKI; M HASHIDA

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Feb. 1993, Peer-reviewed

  
• PHARMACOKINETICS OF RECEPTOR-MEDIATED HEPATIC-UPTAKE OF GLYCOSYLATED ALBUMIN IN MICE

  M NISHIKAWA; Y OHTSUBO; J OHNO; T FUJITA; Y KOYAMA; F YAMASHITA; M HASHIDA; H SEZAKI

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Sep. 1992, Peer-reviewed

  
• DEMONSTRATION OF THE RECEPTOR-MEDIATED HEPATIC-UPTAKE OF DEXTRAN IN MICE

  M NISHIKAWA; F YAMASHITA; Y TAKAKURA; M HASHIDA; H SEZAKI

  JOURNAL OF PHARMACY AND PHARMACOLOGY, May 1992, Peer-reviewed

  
• PHARMACOKINETIC ANALYSIS OF UPTAKE PROCESS OF LACTOSAMINATED ALBUMIN IN RAT-LIVER CONSTANT INFUSION EXPERIMENTS

  K NISHIDA; T TAKINO; Y EGUCHI; F YAMASHITA; M HASHIDA; H SEZAKI

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Feb. 1992, Peer-reviewed

  
• ANALYSIS OF ACTION MECHANISM OF PERCUTANEOUS PENETRATION ENHANCER BASED ON PHYSIOLOGICAL SKIN DIFFUSION-MODEL

  F YAMASHITA; M HASHIDA; H SEZAKI

  JOURNAL OF PHARMACOBIO-DYNAMICS, Feb. 1992, Peer-reviewed

  
• ANALYSIS OF DRUG PENETRATION THROUGH THE SKIN BY THE 2-LAYER SKIN MODEL

  H OKAMOTO; F YAMASHITA; K SAITO; M HASHIDA

  PHARMACEUTICAL RESEARCH, Nov. 1989, Peer-reviewed

  

Misc.

• 抗テネイシンCペプチドアプタマーPETプローブの高感度化に関する検討

  向井 英史; 松村 一史; 川上 茂; 高橋 麻衣子; 造田 真希; 林中 恵美; 山下 富義; 橋田 充; 和田 康弘; 渡辺 恭良

  日本DDS学会学術集会プログラム予稿集, Jun. 2012

  
• フォーカスグループ(FG)活動の新しい動き

  山下 富義; 小口 敏夫; 荻原 琢男; 岡本 浩一; 森下 真莉子; 宇都口 直樹; 前田 和哉; 杉林 堅次; 並木 徳之; 高倉 喜信; 将来ビジョン委

  薬剤学: 生命とくすり, Apr. 2009

  
• Regulation of Store Ca²⁺ Level in HEK293 Cells Expressing Type 2 Ryanodine Receptor (RyR2) with CPVT Mutations

  Fumiyoshi Yamashita

  Biophysical Journal, 02 Feb. 2018

  
• Modulation of Ca²⁺ dynamics by disease-linked RyR2s in cultured non-cardiac and cardiac cells

  Fumiyoshi Yamashita

  Journal of Pharmacological Sciences, Mar. 2017

  
• Comparison of Ca²⁺ release properties of RyR2 mutations causing catecholaminergic polymorphic ventricular tachycardia versus idiopathic ventricular fibrillation

  Fumiyoshi Yamashita

  Journal of Pharmacological Sciences, Mar. 2016

  
• 先導的薬剤師養成に向けた実践的アドバンスト教育プログラムの共同開発 SP養成・PBLチュートリアル教育プログラム及び高度医療人養成・レギュラトリーサイエンスプログラム

  山下 富義; 入江 徹美; 新田 淳美; 高倉 喜信; 赤池 昭紀

  日本薬学会年会要旨集, Mar. 2016

  
• Effects of arrhythmogenic mutations in type-2 ryanodine receptor on Ca²⁺ induced Ca²⁺ release activity and Ca²⁺ homeostasis in HEK293 cells

  Fumiyoshi Yamashita

  Journal of Pharmacological Sciences, Jul. 2015

  
• 先導的薬剤師養成に向けた実践的アドバンスト教育プログラムの共同開発 SP養成・PBLチュートリアル教育プログラム及び高度医療人養成・レギュラトリーサイエンスプログラム

  入江 徹美; 新田 淳美; 山下 富義; 栄田 敏之; 高倉 喜信; 赤池 昭紀

  日本薬学会年会要旨集, Mar. 2015

  
• 超音波応答性マンノース修飾リポプレックスを用いたDNAワクチン療法の開発

  運敬太; 川上茂; 鈴木亮; 丸山一雄; 山下富義; 橋田充

  薬剤学, 20 Apr. 2010

  
• マンノース修飾ナノバブルリポプレックスと超音波照射による標的細胞選択的かつ高効率遺伝子導入法の開発

  運敬太; 川上茂; 鈴木亮; 丸山一雄; 山下富義; 橋田充

  日本薬学会年会要旨集, 05 Mar. 2010

  
• 超音波照射の併用によるマンノース修飾リポプレックスを用いた細胞選択的な遺伝子導入効率の増強

  運敬太; 川上茂; 鈴木亮; 丸山一雄; 山下富義; 橋田充

  日本薬学会年会要旨集, 05 Mar. 2009

  
• Simulations Using a Visual Interface EMACI for Evolutional Computation

  OHYAMA Kisa; ITOH Takayuki; YAMASHITA Fumiyoshi; KOYAMADA Koji

  日本シミュレーション学会大会発表論文集 : シミュレーション・テクノロジー・コンファレンス・計算電気・電子工学シンポジウム, 19 Jun. 2008

  
• Development of the inclusive evaluation method for the percutaneous absorption III : Prediction of human dermal concentration of chemicals in various vehicles

  KOUZUKI Hirokazu; YAMASHITA Fumiyoshi; ITAGAKI Hiroshi; HASHIDA Mitsuru

  Alternatives to animal testing and experimentation : AATEX, 31 Mar. 2006

  
• Prediction of skin permeability of compounds from their molecular structure

  YAMASHITA Fumiyoshi; KOUZUKI Hirokazu; ITAGAKI Hiroshi; HASHIDA Mitsuru

  Alternatives to animal testing and experimentation : AATEX, 31 Mar. 2006

  
• 創薬研究を支援する in silico 薬物動態スクリーニング法

  山下 富義

  Drug delivery system, 10 May 2004

  
• Increased gene and functional expression of P-glycoprotein in Caco-2 by streching stress stimulation

  高谷直樹; 津田真弘; 宗可奈子; 樋口ゆり子; 山下富義

  日本薬剤学会年会講演要旨集(CD-ROM), 2022

  
• Annual Report of APSTJ Future Vision : Working Group Activity 2006

  YAMASHITA Fumiyoshi

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 01 Sep. 2007

  
• ヒト肝臓癌細胞におけるレチノイドの増殖抑制効果

  八木 寛子; 川上 茂; 樋口 ゆり子; 山下 富義; 橋田 充

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 10 May 2007

  
• 抗原提示細胞指向型キャリアを用いたNFκBデコイ送達に基づくラット心移植急性拒絶におけるサイトカイン産生抑制

  樋口 ゆり子; 岩井 美栄子; 川上 茂; 山下 富義; 三原 潔; 谷川原 祐介; 橋田 充

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 10 May 2007

  
• 4-HPR封入ポリマーミセル製剤による新規癌治療法への応用展開

  奥田 知将; 川上 茂; 山本 竜広; 横山 昌幸; 山下 富義; 橋田 充

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 10 May 2007

  
• Methods of In Silico Prediction of Drug Absorption and Their Recent Applications

  HARA Hideto; YAMASHITA Fumiyoshi; HASHIDA Mitsuru

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 01 Jul. 2004

  
• In Silico薬物動態予測とDDS

  山下 富義; 橋田 充

  Drug delivery system, 10 May 2003

  
• Biodistribution Characteristics of Surface Charge Improved Lysine Dendrimers after Intravenous Injection in Mice

  OKUDA Tatsuya; KAWAKAMI Shigeru; TERAI Kumiko; YAMASHITA Fumiyoshi; HASHIDA Mitsuru

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2009

  
• 化学修飾SODのパラコート肺障害抑制効果 : ウサギ肺胞上皮細胞初代培養系による評価

  石本 奈々子; 山下 富義; 橋田 充

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 05 Mar. 2001

  
• DIFFERENTIAL ROLE OF SERUM MANNAN BINDING PROTEIN IN PHARMACOKINETICS OF MANNOSYLATED POLYMERIC AND PARTICULATE DRUG CARRIERS

  OPANASOPIT P.; YAMASHITA F.; NISHIKAWA M.; TAKAKURA Y.; HASHIDA M.

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 05 Mar. 2001

  
• ガラクトース修飾エマルションを用いた肝実質細胞選択的薬物デリバリー

  石田 絵美; 山田 真起子; 川上 茂; 山下 富義; 橋田 充

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 05 Mar. 2001

  
• 新規肝細胞選択的遺伝子キャリアーとしての糖修飾ポリエチレンイミンの開発 : ポリエチレンイミン分子量の影響

  森元 健介; 服部 芳幸; 西川 元也; 山下 富義; 橋田 充

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 05 Mar. 2001

  
• THEORETICAL DESIGN OF OPTIMAL PRODRUG FOR SKIN PENETRATION ENHANCEMENT BASED ON A DIFFUSION MODEL

  BANDO Hiroto; YAMASHITA Fumiyoshi; TAKAKURA Yoshinobu; HASHIDA Mitsuru

  薬物動態 = Xenobiotic metabolism and disposition, 20 Sep. 1996

  
• in vivo 投与された非ウイルス性遺伝子導入ベクターの臓器および細胞内分布の評価

  山田 真起子; 西川 元也; 山下 富義; 橋田 充

  薬物動態 = Xenobiotic metabolism and disposition, 17 Sep. 2001

  
• 肝灌流実験系を用いた非ウイルス性ベクターの肝臓局所動態に関する速度論的解析:リポソームキャリアと高分子キャリアの特性比較

  麓 伸太郎; 石塚 雅子; 西川 元也; 山下 富義; 橋田 充

  薬物動態 = Xenobiotic metabolism and disposition, 17 Sep. 2001

  
• QSPR analysis on inhibition of recombinant CYP3A4 activity by structurally diverse compounds using genetic algorithm combined partial least squares method

  WANCHANA Suchada; YAMASHITA Fumiyoshi; HASHIDA Mitsuru

  薬物動態 = Xenobiotic metabolism and disposition, 17 Sep. 2001

  
• 糖修飾リポソームを用いた遺伝子デリバリーと治療への応用

  川上 茂; 山下 富義; 橋田 充

  Drug delivery system, 10 May 2005

  
• System Biology

  YAMASHITA Fumiyoshi

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 01 Jan. 2007

  
• NFκBの核移行性に基づく外来遺伝子の細胞内動態制御

  岡部 貴幸; 倉本 健史; 西川 元也; 山下 富義; 橋田 充

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 05 Mar. 2003

  
• Tissue-specific in vivo gene transfer characteristics following direct injection of plasmid DNA

  THANAKETPAISARN Oranuch; SAKAI Megumi; NISHIKAWA Makiya; YAMASHITA Fumiyoshi; HASHIDA Mitsuru

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 05 Mar. 2003

  
• 物性制御によるガラクトース修飾リポソーム/pDNA複合体の肝細胞選択的遺伝子導入効率の改善

  麓伸 太郎; 伊藤 佳孝; 川上 茂; 西川 元也; 山下 富義; 橋田 充

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 05 Mar. 2003

  
• 定量的癌転移評価モデルにおける活性酸素消去酵素デリバリーによる腹膜播種の抑制

  兵頭 健治; 西川 元也; 山下 富義; 橋田 充

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 05 Mar. 2003

  
• マンノース修飾カチオン性リポソームを用いたDNAワクチンの細胞選択的デリバリー

  服部 芳幸; 鈴木 幸子; 川上 茂; 西川 元也; 山下 富義; 橋田 充

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 05 Mar. 2003

  
• 高分子医薬品の血管透過性改善を目的とした一酸化窒素デリバリー

  勝見 英正; 西川 元也; 山下 富義; 橋田 充

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 05 Mar. 2003

  
• DEVELOPMENT OF HEPATOCYTE-SPECIFIC GENE DELIVERY SYSTEMS BASED ON PHARMACOKINETIC STUDIES

  TAKAKURA Y.; NISHIKAWA M.; YAMASHITA F.; HASHIDA M.

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 01 Apr. 2000

  
• Observation of Histidine-modified Chitosan/pDNA Complexes Escaping from Endosomes

  CHANG Kai-Ling; HIGUCHI Yuriko; KAWAKAMI Shigeru; YAMASHITA Fumiyoshi; HASHIDA Mitsuru

  バイオイメージング, 15 Jul. 2009

  
• 量子ドット蛍光標識法による間葉系幹細胞の体内動態追跡

  呉 サン; 樋口 ゆり子; 川上 茂; 山下 富義; 橋田 充

  バイオイメージング, 30 Oct. 2008

  
• 量子ドットを用いた癌細胞腹膜播種における in vivo マクロファージ分布評価

  樋口 ゆり子; 岡 真千子; 川上 茂; 山下 富義; 橋田 充

  バイオイメージング, 30 Oct. 2008

  
• 皮膚における物質移行動態とその評価,予測

  山下 富義; 橋田 充

  日本香粧品科学会誌, Sep. 1998

  
• P2-115 Development of the inclusive evaluation method for the percutaneous absorption (the second report) : Model for the prediction of percutaneous absorption that considers the effect of vehicles

  Kouzuki Hirokazu; Yamashita Fumiyoshi; Ichikawa Hideyuki; Itagaki Hiroshi; Hashida Mitsuru; Toyoda Hidekazu

  日本環境変異原学会大会プログラム・要旨集, 2004

  
• 皮膚拡散モデルに基づく代謝を伴うIn Vivo薬物経皮吸収動態の解析

  板東 博人; 佐橋 美貴子; 山下 富義; 高倉 喜信; 橋田 充

  薬剤学, 30 Aug. 1995

  
• Generation and application of polydimethylsiloxane-based liver-on-a-chip for pharmacokinetic studies

  出口清香; 出口清香; 津田真弘; 小杉香織; 前田和哉; 楠原洋之; 水口裕之; 水口裕之; 山下富義; 鳥澤勇介; 高山和雄

  日本薬学会年会要旨集(Web), 2021

  
• Dynamic simulation of drug-drug interactions by using multi-level physiological modeling & simulation platforms

  Fumiyoshi Yamashita

  Yakugaku Zasshi, 2018, Peer-reviewed

  
• The development of mechanically formed stable nanobubbles intended for sonoporation-mediated gene transfection

  Rodi Abdalkader; Shigeru Kawakami; Johan Unga; Yuriko Higuchi; Ryo Suzuki; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  DRUG DELIVERY, 2017, Peer-reviewed

  
• COMPUTER-AIDED FULL-AUTOMATIC CONSTRUCTION OF COVARIATE MODELS IN POPULATION PHARMACOKINETIC ANALYSIS

  Fumiyoshi Yamashita; Shuya Yoshida; Mitsuru Hashida

  DRUG METABOLISM REVIEWS, Nov. 2015

  
• 高密度焦点式超音波とバブルリポポリプレックスの併用によるがんへの遺伝子導入

  空閑裕也; 黒崎友亮; 川上茂; 丸山一雄; 山下富義; 橋田充

  日本DDS学会学術集会プログラム予稿集, 05 Jun. 2013

  
• 超音波応答性バブルリポポリプレックスによる腫瘍選択的な遺伝子導入の評価

  黒崎友亮; 川上茂; 丸山一雄; 山下富義; 橋田充

  日本DDS学会学術集会プログラム予稿集, 05 Jun. 2013

  
• 超音波応答性リポポリプレックスを用いたmRNAデリバリー

  井手野泰久; 川上茂; 黒崎友亮; 鈴木亮; 丸山一雄; 山下富義; 橋田充

  遺伝子・デリバリー研究会シンポジウム要旨集, 11 May 2013

  
• マンノース修飾バブルリポプレックスを用いたNF‐κBデコイの腫瘍関連マクロファージへの導入に基づくphenotype制御

  河野裕允; 川上茂; 樋口ゆり子; 鈴木亮; 丸山一雄; 山下富義; 橋田充

  遺伝子・デリバリー研究会シンポジウム要旨集, 11 May 2013

  
• マンノース修飾バブルリポソームを用いたNF‐kappaB活性制御による腫瘍関連マクロファージのphenotype変化

  河野裕允; 川上茂; 樋口ゆり子; 鈴木亮; 丸山一雄; 山下富義; 橋田充

  日本薬剤学会年会講演要旨集(Web), 26 Apr. 2013

  
• カーボンナノチューブ/CpG DNA複合体への近赤外レーザー光照射による癌免疫療法の評価

  SHU JOBUN; HASHIDA YASUHIKO; KAWAKAMI SHIGERU; UMEYAMA TOMOKAZU; IMAHORI HIROSHI; MURAKAMI TATSUYA; YAMASHITA FUMIYOSHI; HASHIDA MITSURU

  アンチセンスシンポジウム講演要旨集, 24 Sep. 2012

  
• In Vivo Real-Time Imaging of Cell Dynamics in Tissues of a Living Mouse by Confocal Microscope with the Suction Device

  Yuriko Higuchi; Yoshimasa Kozu; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  MOLECULAR THERAPY, May 2012

  
• Photothermic regulation of gene expression triggered by laser-induced carbon nanohorns

  Eijiro Miyako; Tomonori Deguchi; Yoshihiro Nakajima; Masako Yudasaka; Yoshihisa Hagihara; Masanori Horie; Mototada Shichiri; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida; Yasushi Shigeri; Yasukazu Yoshida; Sumio Iijima

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2012, Peer-reviewed

  
• 超音波応答性バブルリポプレックスによるsiRNA導入における炎症反応の評価

  吉田允; 川上茂; 運敬太; 丸山一雄; 山下富義; 橋田充

  日本薬剤学会年会講演要旨集(Web), 25 Apr. 2012

  
• カーボンナノチューブ/CpG DNA複合体を用いた近赤外線応答性癌免疫治療法の評価

  SHU JOBUN; HASHIDA YASUHIKO; KAWAKAMI SHIGERU; YAMASHITA FUMIYOSHI; MURAKAMI TATSUYA; UMEYAMA TOMOKAZU; IMAHORI HIROSHI; HASHIDA MITSURU

  日本薬学会年会要旨集, 05 Mar. 2012

  
• 超音波応答性マンノース修飾リポソームを用いたsiRNA送達による抗炎症治療:siRNAの細胞内送達機構と抗炎症治療効果の評価

  運敬太; 川上茂; 樋口ゆり子; 鈴木亮; 丸山一雄; 山下富義; 橋田充

  アンチセンスシンポジウム講演要旨集, 01 Sep. 2011

  
• 超音波応答性マンノース修飾リポプレックスを用いたICAM‐1 siRNA送達による肝虚血再灌流性傷害の抑制

  運敬太; 川上茂; 吉田允; 樋口ゆり子; 鈴木亮; 丸山一雄; 山下富義; 橋田充

  Drug Deliv Syst, 28 May 2011

  
• 超音波応答性マンノース修飾リポプレックスによる遺伝子発現における転写過程の影響

  運敬太; 川上茂; 吉田允; 樋口ゆり子; 鈴木亮; 丸山一雄; 山下富義; 橋田充

  日本薬剤学会年会講演要旨集, 01 May 2011

  
• 免疫活性化能を有するCpGDNA/カーボンナノチューブ複合体の調製と癌免疫効果の評価

  SHU JOBUN; HASHIDA YASUHIKO; KAWAKAMI SHIGERU; YAMASHITA FUMIYOSHI; MURAKAMI TATSUYA; UMEYAMA TOMOKAZU; IMAHORI HIROSHI; HASHIDA MITSURU

  日本薬学会年会要旨集, 05 Mar. 2011

  
• ペプチドを用いて分散されたカーボンナノチューブを利用した光線温熱効果の検討

  TANAKA HIRONORI; SHU JOBUN; HASHIDA YASUHIKO; KAWAKAMI SHIGERU; UMEYAMA TOMOKAZU; MURAKAMI TATSUYA; IMAHORI HIROSHI; YAMASHITA FUMIYOSHI; HASHIDA MITSURU

  日本薬学会年会要旨集, 05 Mar. 2011

  
• 超音波応答性マンノース修飾リポソームを用いたsiRNA送達システムによる新規抗炎症療法の開発

  運敬太; 川上茂; 樋口ゆり子; 鈴木亮; 丸山一雄; 山下富義; 橋田充

  Drug Deliv Syst, 28 May 2010

  
• 近赤外線を利用した癌免疫治療を目的としたCpG DNA/カーボンナノチューブ(CNT)複合体の開発

  SHU JOBUN; HASHIDA YASUHIKO; KAWAKAMI SHIGERU; UMEYAMA TOMOKAZU; IMAHORI HIROSHI; MURAKAMI TATSUYA; YAMASHITA FUMIYOSHI; HASHIDA MITSURU

  Drug Deliv Syst, 28 May 2010

  
• Start-Up of APSTJ Focus Groups : Purpose, Activities, Problems

  YAMASHITA Fumiyoshi

  薬剤学 = The archives of practical pharmacy, 01 Mar. 2010

  
• 超音波応答性リポソームを用いたin‐vivo遺伝子導入法における転写因子活性化と炎症性サイトカイン産生の評価

  運敬太; 川上茂; 鈴木亮; 丸山一雄; 樋口ゆり子; 山下富義; 橋田充

  遺伝子・デリバリー研究会シンポジウム要旨集, 2010

  
• 新規マンノース修飾バブルリポプレックスと超音波照射の併用による標的細胞選択的in vivo遺伝子導入法の開発

  運敬太; 川上茂; 丸山一雄; 山下富義; 橋田充

  薬剤学, 30 Apr. 2009

  
• 新規マンノース修飾バブルリポプレックスによる樹状細胞選択的な遺伝子導入法の開発とDNAワクチン治療への応用

  運敬太; 川上茂; 丸山一雄; 山下富義; 橋田充

  遺伝子・デリバリー研究会シンポジウム要旨集, 2009

  
• Visualization and level-of-detail control for multi-dimensional bioactive chemical data

  Maiko Yamazawa; Takayuki Itoh; Fumiyoshi Yamashita

  PROCEEDINGS OF THE 12TH INTERNATIONAL INFORMATION VISUALISATION, 2008, Peer-reviewed

  
• Visualization of multi-dimensional data of bioactive chemicals using a hierarchical data visualization technique "heiankyoview

  T. Itoh; F. Yamashita

  Conferences in Research and Practice in Information Technology Series, 2006, Peer-reviewed

  
• PEG-poly S-nitrosated bovine serum albumin: a novel nitric oxide donor for delivery of nitric oxide in vivo

  H Katsumi; M Nishikawa; F Yamashita; M Hashida

  NITRIC OXIDE-BIOLOGY AND CHEMISTRY, Aug. 2004

  
• 21世紀のDDSとBT, IT, NT : 将来を担う若手研究者による将来展望

  橋田 充; 五十嵐 理慧; 岡田 純一; 原島 秀吉; 米谷 芳枝; 松村 保広; 水口 裕之; 山下 富義; 横山 昌幸

  Drug delivery system, 10 Jan. 2003

  
• "Glatent membrane permeability" concept: Qsar analysis of inter- and intra-laboratorically variable Caco-2 cell permeability.

  F Yamashita; S Fujiwara; M Hashida

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2002

  
• 2D- and 3D-QSAR of carrier-mediated transport of beta-lactam antibiotics in Caco-2 cells

  WANCHANA Suchada; FUJIWARA Shin-ichi; AKAMATSU Miki; YAMASHITA Fumiyoshi; HASHIDA Mitsuru

  薬剤学, 05 Mar. 2002

  
• 肝臓非実質細胞培養系における糖修飾リガンドの取り込み特性の評価

  樋口 ゆり子; 兵頭 健治; 西川 元也; 山下 富義; 橋田 充

  薬剤学, 05 Mar. 2002

  
• ウサギ肺胞上皮細胞におけるSOD誘導体の活性酸素障害抑制効果

  石本 奈々子; 永吉 慶子; 西川 元也; 山下 冨義; 橋田 充

  薬剤学, 05 Mar. 2002

  
• 新規放射標識法を利用したプラスミドDNAの体内動態 : 遺伝子発現相関の定量的解析

  中野 貴透; 岡部 貴幸; 西川 元也; 山下 富義; 橋田 充

  薬剤学, 05 Mar. 2002

  
• Effect of DNA/liposome mixing ratio on the physicochemical characteristics, cellular uptake and intracellular trafficking of plasmid DNA/cationic liposome complexes and subsequent gene expression (vol 66, pg 255, 2000)

  F Sakurai; R Inoue; Y Nishino; A Okuda; O Matsumoto; T Taga; F Yamashita; Y Takakura; M Hashida

  JOURNAL OF CONTROLLED RELEASE, Oct. 2000

  
• Cell-specific targeting of drugs and genes with glycosylated liposomes: Comparison with glycosylated poly(amino acids)

  M. Hashida; M. Nishikawa; F. Yamashita; Y. Takakura

  ACS Symposium Series, 2000, Peer-reviewed

  
• Loss in keratin barrier potent by a Transglutaminase-1 gene deletion.

  YAMASHITA TOMIYOSHI; MATSUKI MASATO; YASUNO YOICHI; YAMANISHI KIYOFUMI; HASHIDA MITSURU

  薬剤学, 05 Mar. 1999

  
• 分子構造に基づく ab initio 薬物経皮吸収予測

  LIM Chee Wooi; 山下 富義; 高倉 喜信; 橋田 充

  薬剤学, 05 Mar. 1998

  
• Defective stratum corneum and early neonatal death in mice lacking the gene for transglutaminase 1 (keratinocyte transglutaminase)

  M Matsuki; F Yamashita; A Ishida-Yamamoto; K Yamada; C Kinoshita; S Fushiki; E Ueda; Y Morishima; K Tabata; H Yasuno; M Hashida; H Iizuka; M Ikawa; M Okabe; G Kondoh; T Kinoshita; J Takeda; K Yamanishi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Feb. 1998, Peer-reviewed

  
• 図説 コンピュータグラフィックスを利用した高分子化プロドラッグ分子設計の方法論

  山下富義; 西川元也; 橋田充

  日本臨床, Jan. 1998

  
• Defective Cornified Cell Envelope Formation in Mice Lacking the Gene for Transglutaminase 1.

  YAMANISHI KIYOFUMI; MATSUKI MASATO; YASUNO HIROKAZU; YAMASHITA FUMIYOSHI; HASHIDA MITSURU

  膜シンポジウム, Nov. 1997

  
• Characterization of vehicle for skin penetration of emedastine with solubility parameter

  S Harada; Y Takahashi; H Nakagawa; F Yamashita; M Hashida

  23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, Peer-reviewed

  
• Analysis of in vivo skin penetration enhancement by prodrug-enhancer combination based on a diffusion/bioconversion model

  H Bando; M Sahashi; F Yamashita; Y Takakura; M Hashida

  23RD INTERNATIONAL SYMPOSIUM ON CONTROLLED RELEASE OF BIOACTIVE MATERIALS, 1996 PROCEEDINGS, 1996, Peer-reviewed

  
• Molecular design of protein derivatives targeted to the liver via the asialoglycoprotein receptor

  M. Nishikawa; F. Yamashita; Y. Takakura; M. Hashida

  Proceedings of the Controlled Release Society, 1995, Peer-reviewed

  
• Pharmacokinetic analysis of various lipid carrier systems after intratumoral injection in tissue-isolated tumors

  T. Nomura; F. Yamashita; Y. Takakura; N. Hashida

  Proceedings of the Controlled Release Society, 1995, Peer-reviewed

  
• SKIN PENETRATION ENHANCEMENT OF ACYCLOVIR BY PRODRUG-ENHANCER COMBINATION

  H BANDO; F YAMASHITA; Y TAKAKURA; M HASHIDA

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Aug. 1994

  
• Optimization of penetration enhancement based on action mechanism and site of enhancers.

  Yamashita Fumiyoshi; Koyama Yasuo; Bando Hiroto; Takakura Yoshinobu; Hashida Mitsuru

  Drug Delivery System, 1993

  
• Comparison of action mechanism of penetration enhancers based on a skin diffusion model

  F. Yamashita; Y. Koyama; Y. Takakura; M. Hashida

  Proceedings of the Controlled Release Society, 1993, Peer-reviewed

  

Presentations

• Applications of organs-on-a-chip in pharmacokinetics and drug delivery research

  Fumiyoshi Yamashita

  2023 International Conference of The Korean Society of Pharmaceutical Sciences and Technology, 30 Nov. 2023, Invited

  
• 既存概念に基づく効果的な機械学習：薬剤学を事例にして

  山下富義

  日本薬学会第142年会, 28 Mar. 2022, Invited

  
• Targeted delivery of drugs, genes, and cells by using specialized ligand-receptor recognition systems

  Fumiyoshi Yamashita

  International Conference and Exhibition on Pharmaceutical Sciences and Technology 2020, 19 May 2020, Invited

  
• Informatic Technologies for the Prediction of Pharmacokinetic Behaviors

  YAMASHITA Fumiyoshi

  2018 International Conference of The Korean Society of Pharmaceutical Sciences and Technology, 22 Nov. 2018, Invited

  
• Application of machine learning techniques to pharmacokinetic analysis

  YAMASHITA Fumiyoshi

  13th France-Japan Drug Delivery System Symposium, 22 Oct. 2018, Invited

  
• Curriculum towards training pharmacist scientists: Case in Kyoto University

  YAMASHITA Fumiyoshi

  The 7th Conference of Asia Pacific Pharmacy Education Network, 06 Oct. 2018, Invited

  
• 創薬テクノロジーとしてのDDS

  山下 富義

  立命館大学創薬科学研究センター 創剤研究コンソーシアム・製剤技術研究コンソーシアム 2018年合同研究会, 24 Aug. 2018, Invited

  
• 薬学系からみた 最近のＤＤＳのトピックと将来展望

  山下 富義

  第34回日本DDS学会学術集会, 22 Jun. 2018, Invited

  
• Data mining technologies in accelerating ADME screening

  YAMASHITA Fumiyoshi

  The 5th Asian Symposium on Pharmaceutical Science and Technology & the 5th Enlarged Editorial Board Conference of the Asian Journal of Pharmaceutical Sciences, 09 May 2018, Invited

  
• Data mining and visualization techniques for ADME screening in early drug discovery

  YAMASHITA Fumiyoshi

  CUHK One-day Forum: Better, Safer, and Cheaper Medicine: A 21st Century Mandate, 04 Nov. 2017, Invited

  
• 多階層生体機能モデリング・シミュレーション環境を利用した薬物間相互作用の動的シミュレーション

  山下 富義

  日本薬学会第137年会, 27 Mar. 2017, Invited

  
• In silico pharmacokinetics: from QSAR to system modeling

  YAMASHITA Fumiyoshi

  International Symposium on Drug Delivery and Pharmaceutical Sciences: Beyond the History, 09 Mar. 2017, Invited

  
• 多階層生体機能モデリング＆シミュレーションプラットフォームを利用した薬物動態予測研究

  山下 富義

  第378回CBI学会講演会, 08 Dec. 2016, Invited

  
• 薬物相互作用のin silico予測

  山下 富義

  第37回日本臨床薬理学会学術総会, 02 Dec. 2016

  
• In silico techniques in drug formulation studies

  YAMASHITA Fumiyoshi

  日本薬物動態学会第31年会, 15 Oct. 2016, Invited

  
• Use of informatics technologies for the prediction of pharmacokinetic behaviors

  YAMASHITA Fumiyoshi

  12th France-Japan Drug Delivery System Symposium, 11 Oct. 2016, Invited

  

Books and Other Publications

• Dr. 北野の０から始めるシステムバイオロジー

  浅井 義之; 山下 富義, Contributor, PhysioDesignerによる生理機能の多階層モデル構築とシミュレーション

  羊土社, Apr. 2015, Not refereed

  
• 薬剤学実験法必携マニュアル

  山下 富義, Contributor, 11 動態解析プログラム（in silico系）

  Apr. 2014, Not refereed

  
• 第７版化学便覧 応用化学編

  山下 富義, Contributor, 16.3.1 薬物動態システムの機構と特性

  丸善, Jan. 2014, Not refereed

  
• 薬物の消化管吸収予測研究の最前線

  山下 富義, Contributor, 第2章 Ex vivo によるＢＡ予測 1. In silico によるバイオアベイラビリティの予測

  メディカルドゥ, 2010, Not refereed

  
• インシリコ創薬科学

  山下 富義, Contributor, 第6章 薬物動態・薬効インフォマティクス

  京都廣川書店, 2008, Not refereed

  
• 分子薬物動態学

  山下 富義, Contributor, C. 薬物体内動態の予測 13 薬物動態特性のインシリコ予測

  南山堂, 2008, Not refereed

  
• 我が国の保健医療の将来 20年後のヒューマンライフを展望する

  山下 富義, Contributor, 第3部 我が国の保健医療の将来展望 第8章 各分野の将来展望 創薬の将来展望-ADME予測とDDSの観点から

  財団法人ヒューマンサイエンス振興財団, 2007, Not refereed

  
• 創薬動態 医薬品創製のための考え方と最新情報

  山下 富義, Contributor, Ⅳ：動態予測 Ⅳ-C In silicoによる薬物動態予測

  日本薬物動態学会, 2006, Not refereed

  
• ドラッグデリバリーシステムの新展開－究極の薬物治療をめざして－

  山下 富義, Contributor, 6. 9 DDS開発におけるITの重要性 9.1 薬物動態のin silico予測

  シーエムシー出版, 2004, Not refereed

  
• ゲノム研究実験ハンドブック

  山下 富義, Contributor, 第7章 ゲノム創薬と薬理ゲノミクス ３．薬物動態ゲノミクス

  2004, Not refereed

  
• 第6版 化学便覧 応用化学編Ⅱ

  山下 富義, Contributor, Ⅵ編 バイオ化学技術 27章 医薬・農薬 27.5 ドラッグデリバリーシステム27.5.2 構造・物性・動態相関

  2003, Not refereed

  
• 今日のＤＤＳ 薬物送達システム

  山下 富義, Contributor, Ⅳ. 膜透過の改善と新しい投与経路 皮膚における吸収促進

  医薬ジャーナル社, 1997, Not refereed

  
• 改訂 図解・夢の薬剤ＤＤＳ

  山下 富義, Contributor, 第３章 新しい投与経路，吸収障壁の克服

  薬業時報社, 1997, Not refereed

  
• Terpenes as Penetration Enhancers

  山下 富義

  Percutaneous Penetration Enhancers,/,309-321, 1995, Not refereed

  
• 図解 夢の薬剤DDS

  山下 富義, Contributor

  薬業時報社,, 1991, Not refereed

  

Industrial Property Rights

• 特許第4280831号, 特開2006-318048, 特願2005-137690, 化合物群表示装置、化合物群表示方法、プログラム、及びコンピュータ読み取り可能な記録媒体

  山下 富義

  
• 特開2008-299363, 特願2007-141362, データベースを可視化するための画像生成方法及びプログラム並びにデータベース表示装置

  伊藤 貴之; 山下 富義

  
• 特開2006-318048, 特願2005-137690, 化合物群表示装置、化合物群表示方法、プログラム、及びコンピュータ読み取り可能な記録媒体

  山下 富義; 伊藤 貴之

  
• WO2006-057268, JP2005021519, シミュレーション装置およびプログラム

  野間 昭典; 山下 富義; 竹内 綾子; 寺島 啓介

  

Awards

• 2001

  日本薬剤学会, 平成13年度日本薬剤学会旭化成製剤学奨励賞Asahi Kasei Pharmaceutics Young Investigator Award
• 2003

  日本薬物動態学会, 日本薬物動態学会奨励賞
• 2004

  日本薬学会薬学研究ビジョン部会, 日本薬学会薬学研究ビジョン部会賞
• 2001

  日本薬剤学会, 日本薬剤学会旭化成製剤学奨励賞
• 2003

  日本薬物動態学会, 日本薬物動態学会奨励賞
• 2004

  日本薬学会薬学研究ビジョン部会, 日本薬学会薬学研究ビジョン部会賞

External funds: Kakenhi

• Development of a microfluidic device that mimics inflammatory bowel disease caused by disruption of the intestinal flora

  Grant-in-Aid for Scientific Research (C)

  Basic Section 47060:Clinical pharmacy-related

  Kyoto University

  Masahiro Tsuda

  From 01 Apr. 2021, To 31 Mar. 2024, Project Closed

  腸内細菌;マイクロ流体デバイス;Organ-on-a-chip;炎症性腸疾患;腸管免疫;Disease-on-a-chip;Gut-on-a-chip;共培養;腸内細菌叢

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K06642/
• Establishment of appropriate management of anti-HIV drugs to suppress the onset of HIV-associated neurocognitive disorder (HAND)

  Grant-in-Aid for Scientific Research (C)

  Basic Section 47060:Clinical pharmacy-related

  Kyoto University

  Masahiro Tsuda

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  抗HIV薬;インテグラーゼ阻害薬;トランスポーター;BCRP;P-gp;血液脳関門;HIV関連神経認知障害;有害事象自発報告データベース;脂溶性;脳移行;トランスポータ;HAND

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K06747/
• Muti-step targeted drug delivery to endoplasmic reticulum via retrograde transport systems

  Grant-in-Aid for Scientific Research (B)

  Basic Section 90120:Biomaterials-related

  Kyoto University

  Fumiyoshi Yamashita

  From 01 Apr. 2018, To 31 Mar. 2022, Project Closed

  ドラッグデリバリーシステム;細胞内標的指向化;糖鎖;小胞体;逆行性輸送;ドラッグデリバリー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H03531/
• Targeted delivery of cell medicine by cell surface modification with low molecular weight antibody

  Grant-in-Aid for Scientific Research (B)

  Basic Section 90110:Biomedical engineering-related

  Kyoto University

  Yuriko Higuchi

  From 01 Apr. 2018, To 31 Mar. 2022, Project Closed

  ドラッグデリバリー;間葉系幹細胞;低分子抗体;ドラッグデリバリーシステム;scFv

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H03516/
• Development of safety evaluation system for DDS carrier based on network toxicology

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Mitsuru Hashida

  From 01 Apr. 2016, To 31 Mar. 2020, Project Closed

  安全性評価;DDS;薬物動態学;ドラッグデリバリーシステム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H01861/
• Mechanism of anti-inflammatory action of self-assembling heparion nanoparticles

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  FUMIYOSHI YAMASHITA

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  ヘパリン誘導体;抗炎症反応;数理モデリング;転写因子;因子分析;マイクロアレイ解析;テキストマイニング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K08071/
• Development of novel gene-switch system inducing inflammatory tissue-selective gene expression and realizing DDS for stem cell

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Mitsuru HASHIDA

  From 01 Apr. 2013, To 31 Mar. 2015, Project Closed

  遺伝子発現制御;炎症;幹細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25670259/
• Full-automatic PopPK modeling utilizing an evolutionary algorithm

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Fumiyoshi YAMASHITA

  From 01 Apr. 2013, To 31 Mar. 2015, Project Closed

  母集団薬物動態解析;共変量モデル;遺伝的アルゴリズム;遺伝的数式プログラミング;個体間変動;拡張最小二乗法;薬物動態;母集団解析;パラメータ推定;機械学習

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25670073/
• Development of heparin-based nanoparticles with multi-functional biological properties intended for rheumatoid arthritis therapy

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Fumiyoshi YAMASHITA

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  ドラッグデリバリー;ヘパリンナノ粒子;関節リウマチ;マクロファージ;炎症性サイトカイン;TLR-4

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659022/
• Therapeutic strategy of drug delivery systems utilizing unique tumor environment

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Mitsuru HASHIDA

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  ドラッグデリバリー;核酸医療;がん治療;免疫活性化;小胞体ストレス;ナノバイオ材料;超音波医科学;がん微小環境;ナノ粒子;ターゲティング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23240072/
• Integrated analysis of biological interaction of small molecules at the molecular level of living organisms

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  Fumiyoshi YAMASHITA

  From 01 Apr. 2011, To 31 Mar. 2015, Project Closed

  生体生命情報学;薬物動態;構造活性相関;薬剤反応性;酵素誘導;生理学的モデル;テキストマイニング;モデル化;分子間相互作用

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23136102/
• Establishment of Integrative Multi-level Systems Biology and its Applications

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Osaka University

  YOSHIHISA KURACHI

  From 01 Apr. 2010, To 31 Mar. 2016, Project Closed

  システム生物学;生理学;生物物理学;心臓;不整脈;薬物動態;全身循環;代謝;薬物動態学;生物物理;生物学

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-22136001/
• Natural Language Processing-Based Comprehensive Data Analysis for Interaction Between Chemicals and Drug Metabolism Network

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Fumiyoshi YAMASHITA

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  薬物代謝;薬物間相互作用;自然言語処理;テキストマイニング;構造活性相関;自然言語解析;インシリコ予測;ネットワーク解析;薬物相互作用

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21390008/
• Natural language processing-based acquisition and analysis of information of drug metabolism

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Fumiyoshi YAMASHITA

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  薬物代謝;テキストマイニング;自然言語処理;構造活性相関;情報可視化;判別分析;決定木モデル;階層型データ;多目的同時最適化;遺伝的アルゴリズム;化合物情報, drug metabolism;text mining;natural language processing;structure-activity relationship;information visualization;discrimination analysis

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590140/
• Development of gene carriers based on in vivo and intracellular distribution real-time analysis

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Hashida MITSURU

  From 01 Apr. 2006, To 31 Mar. 2009, Project Closed

  ドラッグデリバリー;遺伝子治療;遺伝子デリバリー;プラスミドDNA;サイトカイン;NFκB;エンドソーム;リポソーム;ポリマー;癌;ターゲティング;免疫応答;NFkB;カチオン性リポソーム;プロトンスボンジ効果;非ウィルス性キャリア

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18209006/
• Development of bioimaging method and targeted drug delivery system for inhibiting tumor proliferation and metastasis

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  Mitsuru HASHIDA

  From 01 Apr. 2005, To 31 Mar. 2010, Project Closed

  DDS;癌ターゲティング;イメージング;遺伝子治療;癌;薬物キャリア;免疫療法;CpGオリゴ;分化誘導量表;レチノイン酸誘導体;腹膜播種;量子ドット;CpG;がん;活性酸素消去酵素;NFκB;カタラーゼ;ターゲティング;リボソーム;高分子ミセル;癌転移

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17016035/
• Development of Novel Discrimination Model and Its Application to Predicting P-gp Substrate

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Fumiyoshi YAMASHITA

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  構造活性相関;化合物特性空間;情報可視化;判別分析;ドラッグライクネス;P-糖タンパク質;経口医薬品;P糖タンパク質;化合物超空間;トランスポータ, structure-activity relationship;chemical space;information visualization;pattern recognition;drug-likeness;P-glycoprotein;orally active drugs

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15590129/
• Strategy for optimization of in vivo gene delivery based on systemic control of delivery and transfection

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Mitsuru HASHIDA

  From 01 Apr. 2003, To 31 Mar. 2006, Project Closed

  ドラッグデリバリーシステム;プラスミドDNA;遺伝子デリバリー;NO;遺伝子治療;非ウイルスベクター;活性酸素;NFκB;ターゲティング;キメラタンパク質;NF-κB;化学修飾;核移行シグナル, Drug delivery system;Plasmid DNA;Gene delivery;NO;Gene therapy;Non-viral vector;Reactive oxygen;NFκB

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15209006/
• Genetic Algorithm-Based Optimization of In Silico prediction Models for Oral Absorption

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Fumiyoshi YAMASHITA

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  遺伝的プログラミング;遺伝的アルゴリズム;部分最小二乗法;消化管吸収;吸収予測;溶解度;Caco-2細胞;定量的構造活性相関;部分最小ニ乗法, genetic programming;genetic algorithm;partial least squares method;oral absorption;prediction;solibility;Caco-2 cell permeability;QSAR

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13672252/
• Optimized the gene and drug delivery using liposomes based on the controlled liposomal surface property

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Mitsuru HASHIDA

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  ドラッグデリバリー;ターゲティング;DDS;リポソーム;糖修飾;エンドサイトーシス;受容体介在性;体内動態, Drug delivery;Targeting;DDS;Liposome;Sugar modification;Endocytosis;Receptor-mediated;Biodistribution

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13470477/
• Development of local drug disposition analysis and delivery methods in human solid tumors

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Yoshinobu TAKAKURA

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  固形腫瘍;ドラッグデリバリーシステム;局所投与;遺伝子治療;アンチセンスオリゴヌクレオチド;プラスミドDNA;ヒト腫瘍細胞;単離腫瘍灌流実験系, solid tumors;drug delivery system;local administration;gene therapy;antisense oligonucleotide;plasmid DNA

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12557212/
• がん遺伝子治療の基盤となる遺伝子in vivoデリバリー法の開発

  Grant-in-Aid for Scientific Research on Priority Areas (C)

  Biological Sciences

  Kyoto University

  橋田 充

  From 01 Apr. 2000, To 31 Mar. 2001, Project Closed

  癌遺伝子治療;カチオン性リポソーム;X線小角散乱法;原子間力顕微鏡;構造解析;インターフェロン-β;転移性肺癌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12217069/
• 受容体介在性エンドサイトーシスを利用した活性酸素分解酵素のダブルターゲティング

  Grant-in-Aid for Exploratory Research

  Kyoto University

  橋田 充

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  活性酸素;カタラーゼ;SOD;虚血再灌流障害;化学修飾;肝臓ターゲティング;ダブルターゲティング;受容体介在性エンドサイトーシス;肝臓

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11877410/
• 角質バリアー機能におけるコルネオサイトエンベロープの生物物理学的意義の解明

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Kyoto University

  山下 富義

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  角質層;角質バリアー;角質エンベロープ;細胞膜流動性;蛍光異方性;ESRスペクトル法;FTIRスペクトル法;反射赤外吸収スペクトル法;電子スピン共鳴スペクトル法;膜流動性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11771411/
• 遺伝子医薬品の体内動態および細胞取り込み機構の解明に基づくデリバリー戦略の確立

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Yoshinobu TAKAKURA

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  遺伝子治療;DNAワクチン;プラスミドDNA;マクロファージ;細胞取り込み;スカベンジャー受容体;CpGモチーフ;腫瘍壊死因子;インターロイキン-6;ポリアニオン;活性化, gene therapy;DNA vaccination;plasmid DNA;macrophage;cellular uptake;scavenger receptor;CpG motif;tumor necrosis factor

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11672257/
• 分子軌道法とニューラルネットワークを基盤とした薬物吸収予測システムの開発

  Grant-in-Aid for Scientific Research (B).

  KYOTO UNIVERSITY

  Mitsuru HASHIDA

  From 01 Apr. 1999, To 31 Mar. 2001, Project Closed

  薬物吸収;構造活性相関;多変量解析;分子軌道法;ニューラルネットワーク;皮膚拡散モデル;経皮吸収;構造動態相関解析;基剤物性;重回帰分析, drug absorption;quantitative structure;activity relationship;multivariate analysis;molecular orbital calculation;artificial neural network;skin diffusion model

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11557192/
• がん遺伝子治療の基盤となる遺伝子in vivoデリバリー法の開発

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Kyoto University

  橋田 充

  From 01 Apr. 1999, To 31 Mar. 2000, Project Closed

  遺伝子治療;非ウイルスベクター;体内動態;キャリアー;ターゲティング;エンドサイトーシス;細胞内動態;膜融合性ペプチド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11140233/
• 皮膚内薬物代謝挙動を考慮した総合的経皮吸収動態モデルの確立

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Kyoto University

  山下 富義

  From 01 Apr. 1997, To 31 Mar. 1999, Project Closed

  経皮吸収;吸収予測;拡散モデル;薬物代謝;プロドラッグ;吸収促進剤

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09771945/
• 拡散モデルに基づく経皮吸収促進法の予測理論の確立:促進効果に及ぼす基剤の影響

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Kyoto University

  山下 富義

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  経皮吸収;吸収促進剤;基剤;皮膚拡散モデル;高速ラプラス逆変換;溶解度パラメータ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06772102/
• 低分子抗体を用いた幹細胞デリバリーによる肝線維化治療

  Grant-in-Aid for Scientific Research (B)

  Basic Section 90110:Biomedical engineering-related

  Kyoto University

  樋口 ゆり子

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  ドラッグデリバリー;間葉系幹細胞;肝線維化治療;ドラッグデリバリーシステム;低分子抗体;肝炎

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H03940/
• Microphysiological system-based analysis of inflammatory sprials triggered by abnormal gut motility

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47060:Clinical pharmacy-related

  Kyoto University

  山下 富義

  From 01 Apr. 2023, To 31 Mar. 2027, Granted

  生体模倣デバイス;腸運動;炎症性腸疾患;炎症スパイラル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02650/
• 糖代謝疾患の時間発展評価を目指した仮想現実統合型生体チップモデルの開拓

  Grant-in-Aid for Challenging Research (Pioneering)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kyoto University

  山下 富義

  From 30 Jun. 2023, To 31 Mar. 2026, Granted

  Organ-on-a-chip;制御システム;糖代謝;数理モデル;臓器チップ;糖代謝疾患;シミュレーション

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K17475/
• Microphysiological system-based analysis of inflammatory sprials triggered by abnormal gut motility

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47060:Clinical pharmacy-related

  Kyoto University

  山下 富義

  From 01 Apr. 2023, To 31 Mar. 2027, Granted

  生体模倣デバイス;腸運動;炎症性腸疾患;炎症スパイラル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27341/
• Elucidation of Inflammatory Mechanisms by Nrf2 Regulation in a Smoking Exposure Model and Development of Novel Therapy for Laryngeal Inflammatory Disease

  Grant-in-Aid for Scientific Research (C)

  Basic Section 47060:Clinical pharmacy-related

  Kyoto University

  喜多 知子

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  喫煙曝露;炎症;喉頭;Nrf2

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K09957/
• 低分子抗体を用いた幹細胞デリバリーによる肝線維化治療

  Grant-in-Aid for Scientific Research (B)

  Basic Section 90110:Biomedical engineering-related

  Kyoto University

  樋口 ゆり子

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  ドラッグデリバリー;間葉系幹細胞;肝線維化治療;ドラッグデリバリーシステム;低分子抗体;肝炎

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K25194/

External funds: others

• Development of multi-dimensionally glyco-targeted nano-DDSs

  創薬基盤推進研究事業

  From May 2017, To 31 Mar. 2020

  代表

Education

Teaching subject(s)

• From 01 Apr. 2025, To 31 Mar. 2026

  Introduction to Pharmaceutical Sciences and Ethics

  U129, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  ILAS Seminar-E2

  Z002, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Clinical Research

  C503, Fall, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Interprofessional Clinical Exposure

  C407, Spring, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Pharmaceutical R&D Exercise II

  A405, Spring, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Pharmaceutical R&D Exercise 2

  C405, Spring, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Pharmacometrics

  C311, Spring, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Laboratory for medical ethics

  A407, Fall, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Laboratory Practice in Pharmaceutical Sciences II

  6304, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  4207, Fall, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Laboratory Practice in Pharmaceutical Sciences I

  6303, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  4207, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  4207, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  国試連絡用

  B997, Year-long, Faculty of Pharmaceutical Sciences, 0
• From 01 Apr. 2025, To 31 Mar. 2026

  共用試験関係

  B999, Year-long, Faculty of Pharmaceutical Sciences, 0
• From 01 Apr. 2025, To 31 Mar. 2026

  実務実習

  B998, Year-long, Faculty of Pharmaceutical Sciences, 0
• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Laboratory Techniques in Pharmaceutical Sciences

  8401, Spring, Graduate School of Pharmaceutical Sciences, 0.5
• From 01 Apr. 2025, To 31 Mar. 2026

  Research Training(Education of Clinical Pharmacy)

  E821, Year-long, Faculty of Pharmaceutical Sciences, 14
• From 01 Apr. 2025, To 31 Mar. 2026

  特別実習[数理治療薬学]

  E825, Year-long, Faculty of Pharmaceutical Sciences, 14
• From 01 Apr. 2025, To 31 Mar. 2026

  Clinical Clerkship in Hospital Pharmacy

  E901, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2025, To 31 Mar. 2026

  Research Training(Quantitative Pharmaceutics)

  D177, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2025, To 31 Mar. 2026

  Clinical Clerkship in Community Pharmacy

  B902, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2025, To 31 Mar. 2026

  Clinical Clerkship in Community Pharmacy

  E902, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2025, To 31 Mar. 2026

  Clinical Clerkship in Hospital Pharmacy

  B901, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2025, To 31 Mar. 2026

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  1028, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Medicinal Fundamental Science (Practice)

  0961, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  1208, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar for Clinical Pharmacy III

  6103, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar for Clinical Pharmacy II

  6102, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar for Clinical Pharmacy I

  6101, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Cancer Science

  8211, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  8105, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Pharmacology and Drug Delivery Research Seminar

  2307, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Pharmacology and Drug Delivery Research Seminar

  2307, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  1208, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Laboratory Techniques in Pharmaceutical Sciences

  6003, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Introduction to Clinical Pharmacy

  6001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Pharmacology and Drug Delivery Research Seminar

  2307, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Neuroscience

  8212, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Medicinal Fundamental Science

  8215, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Regeneration Medicine

  8214, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Systems Biology

  8213, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Teaching at University : A Preparing Future Faculyy Program

  8307, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Clinical Pharmacy 1

  A313, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Pharmaceutics 2 (Solid formulations)

  A311, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Medical Sociology

  C313, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Introduction to Clinical Pharmacy

  B355, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Pre-Training for Clinical Clerkship

  B354, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  SGD Classes for Pharmaceutical Research

  C501, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Introduction to Clinical Pharmacy

  E355, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Pre-Training for Clinical Clerkship

  E354, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Research in Pharmaceutical Sciences III

  6203, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Research in Basic Pharmacology and Drug Delivery

  3207, Spring, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Research in Basic Pharmacology and Drug Delivery

  3207, Fall, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Medicinal Fundamental Science (Seminar)

  0960, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Research in Pharmaceutical Sciences II

  6202, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Research in Pharmaceutical Sciences I

  6201, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Research in Basic Pharmacology and Drug Delivery

  3207, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  SGD Classes for Pharmaceutical Research

  C501, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Clinical Pharmacy

  E355, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Pre-Training for Clinical Clerkship

  E354, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Pharmaceutical Sciences III

  6203, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Pharmaceutical Sciences II

  6202, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Pharmaceutical Sciences I

  6201, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Basic Pharmacology and Drug Delivery

  3207, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Fundamental Science (Seminar)

  0960, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Interdisciplinary Sciences

  Y101, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Sciences and Ethics

  U129, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Pharmaceutical Biochemistry A

  8205, Fall, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Pharmaceutical Sciences I

  6303, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  4207, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Organic Chemistry for Drug Discovery A

  8203, Fall, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Physical Chemistry for Drug Discovery B

  8202, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Pharmaceutical Sciences II

  6304, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical R&D Exercise II

  A405, Spring, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical R&D Exercise 2

  C405, Spring, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmacometrics

  C311, Spring, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory for medical ethics

  A407, Fall, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Clinical Research

  C503, Fall, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Interprofessional Clinical Exposure

  C407, Spring, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  共用試験関係

  B999, Year-long, Faculty of Pharmaceutical Sciences, 0
• From 01 Apr. 2023, To 31 Mar. 2024

  実務実習

  B998, Year-long, Faculty of Pharmaceutical Sciences, 0
• From 01 Apr. 2023, To 31 Mar. 2024

  国試連絡用

  B997, Year-long, Faculty of Pharmaceutical Sciences, 0
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Pharmaceutical Sciences

  8401, Spring, Graduate School of Pharmaceutical Sciences, 0.5
• From 01 Apr. 2023, To 31 Mar. 2024

  Clinical Clerkship in Community Pharmacy

  E902, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Clinical Clerkship in Community Pharmacy

  B902, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Clinical Clerkship in Hospital Pharmacy

  B901, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Education of Clinical Pharmacy)

  B822, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Clinical Clerkship in Hospital Pharmacy

  E901, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training (Applied Pharmaceutics and Pharmacokinetics)

  D164, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Drug Delivery)

  D144, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Education of Clinical Pharmacy)

  E821, Year-long, Faculty of Pharmaceutical Sciences, 14
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Drug Delivery)

  E811, Year-long, Faculty of Pharmaceutical Sciences, 14
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Drug Delivery)

  B812, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Pharmaceutical Sciences III

  6203, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Medicinal Fundamental Science (Seminar)

  0960, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Pharmaceutical Sciences II

  6202, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Pharmaceutical Sciences I

  6201, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Basic Pharmacology and Drug Delivery

  3207, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Drug Delivery)

  8144, Year-long, Faculty of Pharmaceutical Sciences, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Clinical Pharmacy

  B355, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Pre-Training for Clinical Clerkship

  B354, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Community Clinical Pharmacy2

  B310, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Pre-Training for Clinical Clerkship

  E354, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  SGD Classes for Pharmaceutical Research

  C501, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Medical Sociology

  C313, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Clinical Pharmacy 1

  A313, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutics 2 (Solid formulations)

  A311, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Clinical Pharmacy

  E355, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Pharmacology and Drug Delivery Research Seminar

  2307, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Physical Chemistry for Drug Discovery

  1217, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Basic Biological Chemistry I

  1213, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Pharmaceutical Sciences

  6003, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Clinical Pharmacy

  6001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  1208, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  1028, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Modern Life Sciences for Drug Discovery

  1027, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Basic Physical Chemistry II

  1212, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Basic Organic Chemistry I

  1209, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  1208, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Pharmaceutical Sciences I

  6005, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Biochemistry

  8103, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Organic Chemistry for Drug Discovery

  8102, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Physical Chemistry for Drug Discovery

  8101, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Neuroscience

  8212, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Cancer Science

  8211, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  8105, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar for Clinical Pharmacy I

  6101, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Pharmaceutical Sciences III

  6007, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Pharmaceutical Sciences II

  6006, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar for Clinical Pharmacy III

  6103, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar for Clinical Pharmacy II

  6102, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Organic Chemistry for Drug Discovery

  1026, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Medicinal Fundamental Science (Practice)

  0961, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Medicinal Fundamental Science

  8215, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Regeneration Medicine

  8214, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Systems Biology

  8213, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Clinical Research

  C503, Fall, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Education of Clinical Pharmacy)

  B822, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Pharmaceutical Sciences III

  6203, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical R&D Exercise 2

  C405, Spring, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Pre-Training for Clinical Clerkship

  E354, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  SGD Classes for Pharmaceutical Research

  C501, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Neuroscience

  8212, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  8105, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical R&D Exercise II

  A405, Spring, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Drug Delivery)

  B812, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  共用試験関係

  B999, Year-long, Faculty of Pharmaceutical Sciences, 0
• From 01 Apr. 2022, To 31 Mar. 2023

  Clinical Pharmacy 1

  A313, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Drug Delivery)

  8144, Year-long, Faculty of Pharmaceutical Sciences, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Community Clinical Pharmacy2

  B310, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Medical Fundamental Science (Seminar)

  0960, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Regeneration Medicine

  8214, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  実務実習

  B998, Year-long, Faculty of Pharmaceutical Sciences, 0
• From 01 Apr. 2022, To 31 Mar. 2023

  Pre-Training for Clinical Clerkship

  B354, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Pharmaceutical Sciences and Ethics

  U129, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Clinical Pharmacy

  B355, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Cancer Science

  8211, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Drug Delivery)

  D144, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Pharmaceutical Sciences I

  6201, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Pharmacology and Drug Delivery Research Seminar

  2307, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutics 2 (Solid formulations)

  A311, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Clinical Pharmacy

  6004, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Laboratory Techniques in Pharmaceutical Sciences

  6003, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Clinical Clerkship in Hospital Pharmacy

  B901, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  1208, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Pharmacy and Biomedical Sciences for Drug Discovery

  8208, Fall, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Interprofessional Clinical Exposure

  C407, Spring, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Interdisciplinary Sciences

  Y101, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory for medical ethics

  A407, Fall, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Basic Pharmacology and Drug Delivery

  3207, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar for Clinical Pharmacy III

  6103, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Basic Pharmacy and Biomedicinal Sciences I

  1215, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Clinical Clerkship in Community Pharmacy

  B902, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Systems Biology

  8213, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Clinical Clerkship in Community Pharmacy

  E902, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  1028, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training (Applied Pharmaceutics and Pharmacokinetics)

  D164, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  4207, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Pharmaceutical Sciences II

  6202, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Clinical Clerkship in Hospital Pharmacy

  E901, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  国試連絡用

  B997, Year-long, Faculty of Pharmaceutical Sciences, 0
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Practice in Pharmaceutical Sciences II

  6304, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Practice in Pharmaceutical Sciences I

  6303, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmacometrics

  C311, Spring, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Laboratory Techniques in Pharmaceutical Sciences

  8401, Spring, Graduate School of Pharmaceutical Sciences, 0.5
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar for Clinical Pharmacy II

  6102, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Medical Sociology

  C313, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Medical Fundamental Science (Practice)

  0961, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar for Clinical Pharmacy I

  6101, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From Apr. 2011, To Mar. 2012

  医療薬学Ｉ（薬剤学）

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  薬剤学１（溶液製剤論）

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  先端医療SGD演習

  Spring, 薬学部
• From Apr. 2011, To Mar. 2012

  医療倫理実習

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  医療実務事前学習

  Year-long, 薬学部
• From Apr. 2011, To Mar. 2012

  Basic Laboratory Techniques in Pharmacy and

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Basic Laboratory Techniques in Pharmacy and

  Fall, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Laboratory Practice in Basic Pharmacodynamic and

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Laboratory Practice in Basic Pharmacodynamic and

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Pharmaceuticals and Medicine

  Spring, 全学共通科目
• From Apr. 2011, To Mar. 2012

  薬学専門実習IV

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  薬学専門実習３

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Frontier SGD Classes for Clinical Pharmacy

  Spring, 薬学部
• From Apr. 2012, To Mar. 2013

  Laboratory for medical ethics

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Pre-Training for Clinical Clerkship

  Year-long, 薬学部
• From Apr. 2012, To Mar. 2013

  Medicinal Pharmacy I(Pharmaceutics)

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Fall, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Advanced Basic Pharmacy and Biomedicinal Sciences I

  Fall, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Seminar for Clinical Pharmacy III

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Seminar for Clinical Pharmacy II

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Seminar for Clinical Pharmacy I

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Advanced Clinical Pharmacy

  Fall, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Pharmaceutics 1 (Liquid Formulations)

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Pharmaceuticals and Medicine

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Pharmaceutical Laboratory III: Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Laboratory Practice in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Laboratory Practice in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Research in Pharmaceutical Sciences III

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Research in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Research in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Pharmaceutics 1 (Liquid Formulations)

  Fall, 薬学部
• From Apr. 2013, To Mar. 2014

  Laboratory for medical ethics

  Fall, 薬学部
• From Apr. 2013, To Mar. 2014

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2013, To Mar. 2014

  Frontier SGD Classes for Clinical Pharmacy

  Spring, 薬学部
• From Apr. 2013, To Mar. 2014

  Pre-Training for Clinical Clerkship

  Year-long, 薬学部
• From Apr. 2013, To Mar. 2014

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Fall, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Advanced Clinical Pharmacy

  Fall, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Seminar for Clinical Pharmacy I

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Seminar for Clinical Pharmacy II

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Seminar for Clinical Pharmacy III

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Research in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Research in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Research in Pharmaceutical Sciences III

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Laboratory Practice in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Laboratory Practice in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Frontier in pharmaceutical science

  Fall, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Pharmaceuticals and Medicine

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Pharmaceutics 1 (Liquid Formulations)

  Fall, 薬学部
• From Apr. 2014, To Mar. 2015

  Pharmacopoeia ; Pharmaceutical Laws

  Spring, 薬学部
• From Apr. 2014, To Mar. 2015

  Pharmaceutical R&D Exercise II

  Spring, 薬学部
• From Apr. 2014, To Mar. 2015

  Laboratory for medical ethics

  Fall, 薬学部
• From Apr. 2014, To Mar. 2015

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2014, To Mar. 2015

  Frontier SGD Classes for Clinical Pharmacy

  Spring, 薬学部
• From Apr. 2014, To Mar. 2015

  Pre-Training for Clinical Clerkship

  Year-long, 薬学部
• From Apr. 2014, To Mar. 2015

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Spring, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Fall, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Basic Pharmacy and Biomedicinal Sciences I

  Fall, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Clinical Pharmacy

  Fall, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Seminar for Clinical Pharmacy I

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Seminar for Clinical Pharmacy II

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Seminar for Clinical Pharmacy III

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Research in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Research in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Research in Pharmaceutical Sciences III

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Laboratory Practice in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Laboratory Practice in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Clinical Clerkship in Community Pharmacy

  Year-long, 薬学部
• From Apr. 2015, To Mar. 2016

  Frontier SGD Classes for Clinical Pharmacy

  Spring, 薬学部
• From Apr. 2015, To Mar. 2016

  Laboratory for medical ethics

  Fall, 薬学部
• From Apr. 2015, To Mar. 2016

  Pre-Training for Clinical Clerkship

  Year-long, 薬学部
• From Apr. 2015, To Mar. 2016

  Pharmaceutical R&D Exercise II

  Spring, 薬学部
• From Apr. 2015, To Mar. 2016

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Fall, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Seminar for Clinical Pharmacy III

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Seminar for Clinical Pharmacy II

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Seminar for Clinical Pharmacy I

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Pharmaceutics 1 (Liquid Formulations)

  Fall, 薬学部
• From Apr. 2015, To Mar. 2016

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2015, To Mar. 2016

  Laboratory Practice in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Laboratory Practice in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Pharmaceutical Sciences III

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Clinical Clerkship in Community Pharmacy

  Year-long, 薬学部
• From Apr. 2015, To Mar. 2016

  Pharmacopoeia ; Pharmaceutical Laws

  Spring, 薬学部
• From Apr. 2016, To Mar. 2017

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Frontier SGD Classes for Clinical Pharmacy

  Spring, 薬学部
• From Apr. 2016, To Mar. 2017

  Laboratory for medical ethics

  Fall, 薬学部
• From Apr. 2016, To Mar. 2017

  Pre-Training for Clinical Clerkship

  Year-long, 薬学部
• From Apr. 2016, To Mar. 2017

  Pharmaceutical R&D Exercise II

  Spring, 薬学部
• From Apr. 2016, To Mar. 2017

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Fall, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Basic Pharmacy and Biomedicinal Sciences I

  Fall, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Fundamental Chemical Experiments

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Seminar for Clinical Pharmacy III

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Seminar for Clinical Pharmacy II

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Seminar for Clinical Pharmacy I

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Clinical Pharmacy

  Fall, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Pharmaceutics 1 (Liquid Formulations)

  Fall, 薬学部
• From Apr. 2016, To Mar. 2017

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2016, To Mar. 2017

  Laboratory Practice in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Laboratory Practice in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Pharmaceutical Sciences III

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Clinical Clerkship in Community Pharmacy

  Year-long, 薬学部
• From Apr. 2016, To Mar. 2017

  Pharmacopoeia ; Pharmaceutical Laws

  Spring, 薬学部
• From Apr. 2017, To Mar. 2018

  Frontier SGD Classes for Clinical Pharmacy

  Spring, 薬学部
• From Apr. 2017, To Mar. 2018

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Laboratory for medical ethics

  Fall, 薬学部
• From Apr. 2017, To Mar. 2018

  Pre-Training for Clinical Clerkship

  Year-long, 薬学部
• From Apr. 2017, To Mar. 2018

  Pharmaceutical R&D Exercise II

  Spring, 薬学部
• From Apr. 2017, To Mar. 2018

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Fall, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research Training(Education of Clinical Pharmacy)

  Year-long, 薬学部
• From Apr. 2017, To Mar. 2018

  Research Training(Drug Delivery)

  Year-long, 薬学部
• From Apr. 2017, To Mar. 2018

  Research Training(Drug Delivery)

  Year-long, 薬学部
• From Apr. 2017, To Mar. 2018

  Clinical Clerkship in Hospital Pharmacy

  Year-long, 薬学部
• From Apr. 2017, To Mar. 2018

  Introduction to Clinical Pharmacy

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Seminar for Clinical Pharmacy III

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Seminar for Clinical Pharmacy II

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Seminar for Clinical Pharmacy I

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Pharmaceutics 1 (Liquid Formulations)

  Fall, 薬学部
• From Apr. 2017, To Mar. 2018

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Laboratory Practice in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Laboratory Practice in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Pharmaceutical Sciences III

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Clinical Clerkship in Community Pharmacy

  Year-long, 薬学部
• From Apr. 2017, To Mar. 2018

  Biopharmaceutics (LIMS)

  Fall, 医学研究科
• From Apr. 2018, To Mar. 2019

  共用試験関係

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory for medical ethics

  Fall, 薬学部
• From Apr. 2018, To Mar. 2019

  Pre-Training for Clinical Clerkship

  Fall, 薬学部
• From Apr. 2018, To Mar. 2019

  Pharmaceutical R&D Exercise II

  Spring, 薬学部
• From Apr. 2018, To Mar. 2019

  国試連絡用

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Community Clinical Pharmacy2

  Spring, 薬学部
• From Apr. 2018, To Mar. 2019

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Fall, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Basic Pharmacy and Biomedicinal Sciences I

  Fall, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Interprofessional Clinical Exposure

  Spring, 薬学部
• From Apr. 2018, To Mar. 2019

  実務実習

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Research Training(Education of Clinical Pharmacy)

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Research Training(Drug Delivery)

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Research Training(Drug Delivery)

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Clinical Clerkship in Hospital Pharmacy

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Introduction to Clinical Pharmacy

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Seminar for Clinical Pharmacy III

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Seminar for Clinical Pharmacy II

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Seminar for Clinical Pharmacy I

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Clinical Pharmacy

  Fall, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Introduction to Clinical Pharmacy

  Fall, 薬学部
• From Apr. 2018, To Mar. 2019

  Pharmaceutics 1 (Liquid Formulations)

  Fall, 薬学部
• From Apr. 2018, To Mar. 2019

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Fall, 薬学研究科
• From Apr. 2018, To Mar. 2019

  SGD Classes for Pharmaceutical Research

  Spring, 薬学部
• From Apr. 2018, To Mar. 2019

  Laboratory Practice in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory Practice in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory Practice in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory Practice in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Pharmaceutical Sciences III

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Clinical Clerkship in Community Pharmacy

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Biopharmaceutics

  Fall, 工学研究科
• From Apr. 2018, To Mar. 2019

  Biopharmaceutics (LIMS)

  Fall, 医学研究科
• From Apr. 2019, To Mar. 2020

  共用試験関係

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory for medical ethics

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Pre-Training for Clinical Clerkship

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Pharmaceutical R&D Exercise II

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  国試連絡用

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Community Clinical Pharmacy2

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Basic Pharmacology and Drug Delivery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Basic Pharmacology and Drug Delivery

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Pharmacology and Drug Delivery Research Seminar

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Pharmacology and Drug Delivery Research Seminar

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Clinical Research

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Interprofessional Clinical Exposure

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  実務実習

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Research Training(Education of Clinical Pharmacy)

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Research Training(Drug Delivery)

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Research Training(Drug Delivery)

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Clinical Clerkship in Hospital Pharmacy

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Seminar for Clinical Pharmacy III

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Seminar for Clinical Pharmacy II

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Seminar for Clinical Pharmacy I

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Introduction to Clinical Pharmacy

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  SGD Classes for Pharmaceutical Research

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Pharmaceutical Sciences II

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Pharmaceutical Sciences III

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Pharmaceutical Sciences III

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Pharmaceutical Sciences II

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Clinical Clerkship in Community Pharmacy

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Biopharmaceutics (LIMS)

  Fall, 医学研究科
• From Apr. 2020, To Mar. 2021

  Pharmaceutical Common Achievement Tests

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory for medical ethics

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Pre-Training for Clinical Clerkship

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Pharmaceutical R&D Exercise II

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  国試連絡用

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Community Clinical Pharmacy2

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Basic Pharmacy and Biomedicinal Sciences I

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Basic Pharmacology and Drug Delivery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Basic Pharmacology and Drug Delivery

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Pharmacology and Drug Delivery Research Seminar

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Pharmacology and Drug Delivery Research Seminar

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Clinical Research

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Interprofessional Clinical Exposure

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  実務実習（病３薬２）

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  実務実習（病２薬１）

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  実務実習（病４薬３）

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Research Training(Education of Clinical Pharmacy)

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Research Training(Drug Delivery)

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Research Training(Drug Delivery)

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Clinical Clerkship in Hospital Pharmacy

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Seminar for Clinical Pharmacy III

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Seminar for Clinical Pharmacy II

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Seminar for Clinical Pharmacy I

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Clinical Pharmacy

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Introduction to Clinical Pharmacy

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  SGD Classes for Pharmaceutical Research

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Pharmaceutical Sciences II

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Pharmaceutical Sciences III

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Pharmaceutical Sciences III

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Pharmaceutical Sciences II

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Clinical Clerkship in Community Pharmacy

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Biopharmaceutics (LIMS)

  Fall, 医学研究科
• From Apr. 2021, To Mar. 2022

  Pharmaceutical Common Achievement Tests

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Laboratory for medical ethics

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Pre-Training for Clinical Clerkship

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Pre-Training for Clinical Clerkship

  Fall, 薬学部