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Murakawa, Yasuhiro

Institute for Advanced Study Professor

Murakawa, Yasuhiro
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    Last Updated :2024/11/26

    Basic Information

    Affiliated programs (koza)

    • Graduate School of Medicine, 分子医学系（システムゲノム医学分野）, 教授

    Academic Degree

    • Free University of Berlin(ベルリン自由大学)

    Research History

    • From Dec. 2018, To Present
      IFOM
    • From Dec. 2018, To Present
      RIKEN, 生命医科学研究センター
    • From Aug. 2016, To Nov. 2018
      理化学研究所, イノベーション推進センター
    • From Jun. 2015, To Nov. 2018
      理化学研究所, 予防医療・診断技術開発プログラム
    • From Aug. 2010, To May 2015
      MDC, BIMSB
    • From Apr. 2008, To Jul. 2010
      京都大学医学部付属病院

    Profile

    • Profile

      京都大学医学部を平成20年卒業。京都大学医学部付属病院にて研修医を行った後、ドイツ学術交流会奨学生として平成22年よりマックスデルブリュック分子医学研究所（ドイツベルリン）にてヒトゲノム研究に従事。平成26年ベルリン自由大学にてPhDを取得。平成27年より理化学研究所予防医療・診断技術開発プログラムマネージャー。平成28年より理化学研究所にて研究室を主宰し（平成28年イノベーション推進センターユニットリーダー、平成30年より生命医科学研究センターチームリーダー兼ミラノがん研究所IFOMのグループリーダー）。令和2年より京都大学高等研究院ヒト生物学高等研究拠点（ASHBi）教授。

    Language of Instruction

    • Japanese
    • English

    ID,URL

    researchmap URL

    list
      Last Updated :2024/11/26

      Research

      Research Topics, Overview of the research

      • Research Topics

        Human Genomics, Medical Science, Systems Biology, Molecular Biology

      • Overview of the research

        “What is encoded in the human genome” remains largely unknown. We combine classical biochemistry, molecular biology, systems biology, informatics, primatology and medicine to study the human genome that makes us human. To elucidate the operating principles of the genome, we investigate how many RNA molecules are read out from which genomic regions by which stimuli and transcription factors, how they are post-transcriptionally regulated (splicing, stability control, translation, etc.), and ultimately what functions they exert in each cell that makes up the human body. These processes need to be observed in detail, and the huge amount of data obtained needs to be analyzed in an integrated manner. To this end, our lab members from various backgrounds have come together and used cutting-edge technologies such as the NET-CAGE, single cell technologies, short- and long-read sequencing, artificial intelligence and imaging. By developing our own original genomic technologies that can solve paradigms that cannot be otherwise solved, we establish new scientific concepts and new innovative future medicine.

      Research Interests

      • ヒトゲノム解析
      • 医学
      • ヒト生物学
      • バイオインフォマティクス
      • 次世代シークエンス解析
      • エンハンサー
      • 遺伝子発現制御
      • シングルセル解析
      • 進化遺伝学

      Research Areas

      • Life sciences, Systems genomics
      • Life sciences, Genomics
      • Life sciences, Molecular biology

      Papers

      • Corrigenda: SecA defects are accompanied by dysregulation of MukB, DNA gyrase, chromosome partitioning and DNA superhelicity in Escherichia coli
        Shun Adachi; Yasuhiro Murakawa; Sota Hiraga
        Microbiology (United Kingdom), 2020
      • An atlas of transcribed enhancers across helper T cell diversity for decoding human diseases.
        Akiko Oguchi; Akari Suzuki; Shuichiro Komatsu; Hiroyuki Yoshitomi; Shruti Bhagat; Raku Son; Raoul Jean Pierre Bonnal; Shohei Kojima; Masaru Koido; Kazuhiro Takeuchi; Keiko Myouzen; Gyo Inoue; Tomoya Hirai; Hiromi Sano; Yujiro Takegami; Ai Kanemaru; Itaru Yamaguchi; Yuki Ishikawa; Nao Tanaka; Shigeki Hirabayashi; Riyo Konishi; Sho Sekito; Takahiro Inoue; Juha Kere; Shunichi Takeda; Akifumi Takaori-Kondo; Itaru Endo; Shinpei Kawaoka; Hideya Kawaji; Kazuyoshi Ishigaki; Hideki Ueno; Yoshihide Hayashizaki; Massimiliano Pagani; Piero Carninci; Motoko Yanagita; Nicholas Parrish; Chikashi Terao; Kazuhiko Yamamoto; Yasuhiro Murakawa
        Science (New York, N.Y.), 05 Jul. 2024
      • 炎症性微小環境、三次リンパ組織の腎組織障害メカニズムの解明
        好川 貴久; 小口 綾貴子; 鳥生 直哉; 佐藤 有紀; 山本 拓也; 村川 泰裕; 柳田 素子
        日本臨床分子医学会学術総会プログラム・抄録集, Apr. 2024
      • 腎三次リンパ組織の形成メカニズムの解明
        好川 貴久; 小口 綾貴子; 佐藤 有紀; 山本 拓也; 村川 泰裕; 柳田 素子
        日本内科学会雑誌, Feb. 2022
      • Regulation of lymphoid-myeloid lineage bias through Regnase-1/3-mediated control of Nfkbiz.
        Takuya Uehata; Shinnosuke Yamada; Daisuke Ori; Alexis Vandenbon; Amir Giladi; Adam Jelinski; Yasuhiro Murakawa; Hitomi Watanabe; Kazuhiro Takeuchi; Kazunori Toratani; Takashi Mino; Hisanori Kiryu; Daron M Standley; Tohru Tsujimura; Tomokatsu Ikawa; Gen Kondoh; Markus Landthaler; Hiroshi Kawamoto; Hans-Reimer Rodewald; Ido Amit; Ryo Yamamoto; Masaki Miyazaki; Osamu Takeuchi
        Blood, 03 Nov. 2023
      • Tertiary Lymphoid Tissues Are Microenvironments with Intensive Interactions between Immune Cells and Proinflammatory Parenchymal Cells in Aged Kidneys
        Takahisa Yoshikawa; Akiko Oguchi; Naoya Toriu; Yuki Sato; Takashi Kobayashi; Osamu Ogawa; Hironori Haga; Satoko Sakurai; Takuya Yamamoto; Yasuhiro Murakawa; Motoko Yanagita
        Journal of the American Society of Nephrology, 07 Aug. 2023
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      • Mobile element variation contributes to population-specific genome diversification, gene regulation and disease risk.
        Shohei Kojima; Satoshi Koyama; Mirei Ka; Yuka Saito; Erica H Parrish; Mikiko Endo; Sadaaki Takata; Misaki Mizukoshi; Keiko Hikino; Atsushi Takeda; Asami F Gelinas; Steven M Heaton; Rie Koide; Anselmo J Kamada; Michiya Noguchi; Michiaki Hamada; Yoichiro Kamatani; Yasuhiro Murakawa; Kazuyoshi Ishigaki; Yukio Nakamura; Kaoru Ito; Chikashi Terao; Yukihide Momozawa; Nicholas F Parrish
        Nature genetics, 11 May 2023
      • HTLV-1 bZIP factor impairs DNA mismatch repair system.
        Maki Sakurada-Aono; Takashi Sakamoto; Masayuki Kobayashi; Yoko Takiuchi; Fumie Iwai; Kohei Tada; Hiroyuki Sasanuma; Shigeki Hirabayashi; Yasuhiro Murakawa; Kotaro Shirakawa; Chihiro Sakamoto; Keisuke Shindo; Jun-Ichirou Yasunaga; Masao Matsuoka; Yves Pommier; Shunichi Takeda; Akifumi Takaori-Kondo
        Biochemical and biophysical research communications, 21 Mar. 2023
      • Comprehensive characterization of the embryonic factor LEUTX.
        Lisa Gawriyski; Eeva-Mari Jouhilahti; Masahito Yoshihara; Liangru Fei; Jere Weltner; Tomi T Airenne; Ras Trokovic; Shruti Bhagat; Mari H Tervaniemi; Yasuhiro Murakawa; Kari Salokas; Xiaonan Liu; Sini Miettinen; Thomas R Bürglin; Biswajyoti Sahu; Timo Otonkoski; Mark S Johnson; Shintaro Katayama; Markku Varjosalo; Juha Kere
        iScience, 17 Mar. 2023
      • Two ovarian candidate enhancers, identified by time series enhancer RNA analyses, harbor rare genetic variations identified in ovarian insufficiency.
        Ryuichi Nakagawa; Kei Takasawa; Maki Gau; Atsumi Tsuji-Hosokawa; Hideya Kawaji; Yasuhiro Murakawa; Shuji Takada; Masashi Mikami; Satoshi Narumi; Maki Fukami; Rajini Sreenivasan; Tetsuo Maruyama; Elena Tucker; Liang Zhao; Josephine Bowles; Andrew Sinclair; Peter Koopman; Yoshihide Hayashizaki; Tomohiro Morio; Kenichi Kashimada
        Hum Mol Genet, 03 Feb. 2022, Peer-reviewed
      • DUX4 is a multifunctional factor priming human embryonic genome activation.
        Sanna Vuoristo; Shruti Bhagat; Christel Hydén-Granskog; Masahito Yoshihara; Lisa Gawriyski; Eeva-Mari Jouhilahti; Vipin Ranga; Mahlet Tamirat; Mikko Huhtala; Ida Kirjanov; Sonja Nykänen; Kaarel Krjutškov; Anastassius Damdimopoulos; Jere Weltner; Kosuke Hashimoto; Gaëlle Recher; Sini Ezer; Priit Paluoja; Pauliina Paloviita; Yujiro Takegami; Ai Kanemaru; Karolina Lundin; Tomi T Airenne; Timo Otonkoski; Juha S Tapanainen; Hideya Kawaji; Yasuhiro Murakawa; Thomas R Bürglin; Markku Varjosalo; Mark S Johnson; Timo Tuuri; Shintaro Katayama; Juha Kere
        iScience, 15 Apr. 2022, Peer-reviewed
      • DUX4 regulates oocyte to embryo transition in human
        Sanna Vuoristo; Christel Hydén-Granskog; Masahito Yoshihara; Shruti Bhagat; Lisa Gawriyski; Eeva-Mari Jouhilahti; Anastassius Damdimopoulos; Vipin Ranga; Mahlet Tamirat; Mikko Huhtala; Kosuke Hashimoto; Kaarel Krjutskov; Gaëlle Recher; Sini Ezer; Priit Paluoja; Pauliina Paloviita; Yujiro Takegami; Ai Kanemaru; Karolina Lundin; Tomi Airenne; Timo Otonkoski; Juha S Tapanainen; Hideya Kawaji; Yasuhiro Murakawa; Thomas R Bürglin; Markku Varjosalo; Mark S Johnson; Timo Tuuri; Shintaro Katayama; Juha Kere
        bioRxiv, 12 Aug. 2019
      • Chromosomal-scale de novo genome assemblies of Cynomolgus Macaque and Common Marmoset.
        Vasanthan Jayakumar; Osamu Nishimura; Mitsutaka Kadota; Naoki Hirose; Hiromi Sano; Yasuhiro Murakawa; Yumiko Yamamoto; Masataka Nakaya; Tomoyuki Tsukiyama; Yasunari Seita; Shinichiro Nakamura; Jun Kawai; Erika Sasaki; Masatsugu Ema; Shigehiro Kuraku; Hideya Kawaji; Yasubumi Sakakibara
        Scientific data, 28 Jun. 2021
      • Intravital imaging identifies the VEGF-TXA2 axis as a critical promoter of PGE2 secretion from tumor cells and immune evasion.
        Yoshinobu Konishi; Hiroshi Ichise; Tetsuya Watabe; Choji Oki; Shinya Tsukiji; Yoko Hamazaki; Yasuhiro Murakawa; Akifumi Takaori-Kondo; Kenta Terai; Michiyuki Matsuda
        Cancer research, 25 May 2021
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      • The embryonic ontogeny of the gonadal somatic cells in mice and monkeys.
        Kotaro Sasaki; Akiko Oguchi; Keren Cheng; Yasuhiro Murakawa; Ikuhiro Okamoto; Hiroshi Ohta; Yukihiro Yabuta; Chizuru Iwatani; Hideaki Tsuchiya; Takuya Yamamoto; Yasunari Seita; Mitinori Saitou
        Cell reports, 04 May 2021
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      • Identification of candidate PAX2-regulated genes implicated in human kidney development.
        Yuta Yamamura; Kengo Furuichi; Yasuhiro Murakawa; Shigeki Hirabayashi; Masahito Yoshihara; Keisuke Sako; Shinji Kitajima; Tadashi Toyama; Yasunori Iwata; Norihiko Sakai; Kazuyoshi Hosomichi; Philip M Murphy; Atsushi Tajima; Keisuke Okita; Kenji Osafune; Shuichi Kaneko; Takashi Wada
        Scientific reports, 27 Apr. 2021
      • APOBEC3B is preferentially expressed at the G2/M phase of cell cycle.
        Shigeki Hirabayashi; Kotaro Shirakawa; Yoshihito Horisawa; Tadahiko Matsumoto; Hiroyuki Matsui; Hiroyuki Yamazaki; Anamaria Daniela Sarca; Yasuhiro Kazuma; Ryosuke Nomura; Yoshinobu Konishi; Suguru Takeuchi; Emani Stanford; Hideya Kawaji; Yasuhiro Murakawa; Akifumi Takaori-Kondo
        Biochemical and biophysical research communications, 26 Mar. 2021
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      • Significance of HMGA2 expression as independent poor prognostic marker in perihilar and distal cholangiocarcinoma resected with curative intent.
        Tomoaki Takahashi; Hideya Kawaji; Yasuhiro Murakawa; Yoshihide Hayashizaki; Takashi Murakami; Yasuhiro Yabushita; Yuki Homma; Takafumi Kumamoto; Ryusei Matsuyama; Itaru Endo
        European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology, Feb. 2021
      • CAGE-seq reveals that HIV-1 latent infection does not trigger unique cellular responses in a Jurkat T cell model.
        Hiroyuki Matsui; Kotaro Shirakawa; Yoshinobu Konishi; Shigeki Hirabayashi; Anamaria Daniela Sarca; Hirofumi Fukuda; Ryosuke Nomura; Emani Stanford; Yoshihito Horisawa; Yasuhiro Kazuma; Tadahiko Matsumoto; Hiroyuki Yamazaki; Yasuhiro Murakawa; Emilie Battivelli; Eric Verdin; Yoshio Koyanagi; Akifumi Takaori-Kondo
        Journal of virology, 27 Jan. 2021
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      • CAGE-seq analysis of osteoblast derived from cleidocranial dysplasia human induced pluripotent stem cells.
        Akio Ooki; Shoko Onodera; Akiko Saito; Akiko Oguchi; Yasuhiro Murakawa; Teruo Sakamoto; Kenji Sueishi; Yasushi Nishii; Toshifumi Azuma
        Bone, Dec. 2020
      • HTLV-1 contains a high CG dinucleotide content and is susceptible to the host antiviral protein ZAP.
        Paola Miyazato; Misaki Matsuo; Benjy J Y Tan; Michiyo Tokunaga; Hiroo Katsuya; Saiful Islam; Jumpei Ito; Yasuhiro Murakawa; Yorifumi Satou
        Retrovirology, 16 Dec. 2019
      • Codon bias confers stability to human mRNAs.
        Fabian Hia; Sheng Fan Yang; Yuichi Shichino; Masanori Yoshinaga; Yasuhiro Murakawa; Alexis Vandenbon; Akira Fukao; Toshinobu Fujiwara; Markus Landthaler; Tohru Natsume; Shungo Adachi; Shintaro Iwasaki; Osamu Takeuchi
        EMBO reports, 05 Nov. 2019
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      • NET-CAGE characterizes the dynamics and topology of human transcribed cis-regulatory elements.
        Shigeki Hirabayashi; Shruti Bhagat; Yu Matsuki; Yujiro Takegami; Takuya Uehata; Ai Kanemaru; Masayoshi Itoh; Kotaro Shirakawa; Akifumi Takaori-Kondo; Osamu Takeuchi; Piero Carninci; Shintaro Katayama; Yoshihide Hayashizaki; Juha Kere; Hideya Kawaji; Yasuhiro Murakawa
        Nature genetics, Sep. 2019
      • Endogenous APOBEC3B Overexpression Constitutively Generates DNA Substitutions and Deletions in Myeloma Cells.
        Hiroyuki Yamazaki; Kotaro Shirakawa; Tadahiko Matsumoto; Shigeki Hirabayashi; Yasuhiro Murakawa; Masayuki Kobayashi; Anamaria Daniela Sarca; Yasuhiro Kazuma; Hiroyuki Matsui; Wataru Maruyama; Hirofumi Fukuda; Ryutaro Shirakawa; Keisuke Shindo; Masaki Ri; Shinsuke Iida; Akifumi Takaori-Kondo
        Scientific reports, 09 May 2019
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      • Genomic Instability of iPSCs and Challenges in Their Clinical Applications.
        Masahito Yoshihara; Akiko Oguchi; Yasuhiro Murakawa
        Advances in experimental medicine and biology, 2019
      • Selective Activation of Alternative MYC Core Promoters by Wnt-Responsive Enhancers.
        Jorge A Bardales; Evin Wieser; Hideya Kawaji; Yasuhiro Murakawa; Xavier Darzacq
        Genes, 23 May 2018
      • Hotspots of De Novo Point Mutations in Induced Pluripotent Stem Cells.
        Masahito Yoshihara; Ryoko Araki; Yasuji Kasama; Misato Sunayama; Masumi Abe; Kohji Nishida; Hideya Kawaji; Yoshihide Hayashizaki; Yasuhiro Murakawa
        Cell reports, 10 Oct. 2017
      • HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia.
        Yoko Takiuchi; Masayuki Kobayashi; Kohei Tada; Fumie Iwai; Maki Sakurada; Shigeki Hirabayashi; Kayoko Nagata; Kotaro Shirakawa; Keisuke Shindo; Jun-Ichirou Yasunaga; Yasuhiro Murakawa; Vinodh Rajapakse; Yves Pommier; Masao Matsuoka; Akifumi Takaori-Kondo
        Scientific reports, 09 Oct. 2017
      • Genomic Instability of iPSCs: Challenges Towards Their Clinical Applications.
        Masahito Yoshihara; Yoshihide Hayashizaki; Yasuhiro Murakawa
        Stem cell reviews and reports, Feb. 2017
      • The Lupus Autoantigen La Prevents Mis-channeling of tRNA Fragments into the Human MicroRNA Pathway.
        Daniele Hasler; Gerhard Lehmann; Yasuhiro Murakawa; Filippos Klironomos; Leonhard Jakob; Friedrich A Grässer; Nikolaus Rajewsky; Markus Landthaler; Gunter Meister
        Molecular cell, 07 Jul. 2016
      • Enhanced Identification of Transcriptional Enhancers Provides Mechanistic Insights into Diseases.
        Yasuhiro Murakawa; Masahito Yoshihara; Hideya Kawaji; Miki Nishikawa; Hatem Zayed; Harukazu Suzuki; Fantom Consortium; Yoshihide Hayashizaki
        Trends in genetics : TIG, Feb. 2016
      • RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway.
        Yasuhiro Murakawa; Michael Hinz; Janina Mothes; Anja Schuetz; Michael Uhl; Emanuel Wyler; Tomoharu Yasuda; Guido Mastrobuoni; Caroline C Friedel; Lars Dölken; Stefan Kempa; Marc Schmidt-Supprian; Nils Blüthgen; Rolf Backofen; Udo Heinemann; Jana Wolf; Claus Scheidereit; Markus Landthaler
        Nature communications, 14 Jul. 2015
      • LARP4B is an AU-rich sequence associated factor that promotes mRNA accumulation and translation.
        Maritta Küspert; Yasuhiro Murakawa; Katrin Schäffler; Jens T Vanselow; Elmar Wolf; Stefan Juranek; Andreas Schlosser; Markus Landthaler; Utz Fischer
        RNA (New York, N.Y.), Jul. 2015
      • Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms.
        Takashi Mino; Yasuhiro Murakawa; Akira Fukao; Alexis Vandenbon; Hans-Hermann Wessels; Daisuke Ori; Takuya Uehata; Sarang Tartey; Shizuo Akira; Yutaka Suzuki; Carola G Vinuesa; Uwe Ohler; Daron M Standley; Markus Landthaler; Toshinobu Fujiwara; Osamu Takeuchi
        Cell, 21 May 2015
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      • Dynamic nature of SecA and its associated proteins in Escherichia coli.
        Shun Adachi; Yasuhiro Murakawa; Sota Hiraga
        Frontiers in microbiology, 2015
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      • Roquin binding to target mRNAs involves a winged helix-turn-helix motif.
        Anja Schuetz; Yasuhiro Murakawa; Eva Rosenbaum; Markus Landthaler; Udo Heinemann
        Nature communications, 11 Dec. 2014
      • A variety of dicer substrates in human and C. elegans.
        Agnieszka Rybak-Wolf; Marvin Jens; Yasuhiro Murakawa; Margareta Herzog; Markus Landthaler; Nikolaus Rajewsky
        Cell, 20 Nov. 2014
      • SecA defects are accompanied by dysregulation of MukB, DNA gyrase, chromosome partitioning and DNA superhelicity in Escherichia coli.
        Shun Adachi; Yasuhiro Murakawa; Sota Hiraga
        Microbiology (Reading, England), Aug. 2014
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      • Integrative analysis revealed the molecular mechanism underlying RBM10-mediated splicing regulation.
        Yongbo Wang; Andreas Gogol-Döring; Hao Hu; Sebastian Fröhler; Yunxia Ma; Marvin Jens; Jonas Maaskola; Yasuhiro Murakawa; Claudia Quedenau; Markus Landthaler; Vera Kalscheuer; Dagmar Wieczorek; Yang Wang; Yuhui Hu; Wei Chen
        EMBO molecular medicine, Sep. 2013
      • Cold-induced RNA-binding proteins regulate circadian gene expression by controlling alternative polyadenylation.
        Yuting Liu; Wenchao Hu; Yasuhiro Murakawa; Jingwen Yin; Gang Wang; Markus Landthaler; Jun Yan
        Scientific reports, 2013
      • Liver transplantation for severe hepatitis in patients with common variable immunodeficiency.
        Yasuhiro Murakawa; Aya Miyagawa-Hayashino; Yasuhiro Ogura; Hiroto Egawa; Shinya Okamoto; Yuji Soejima; Manabu Kurosawa; Shinji Sumiyoshi; Shinji Uemoto; Hironori Haga
        Pediatric transplantation, Sep. 2012
      • The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
        Alexander G Baltz; Mathias Munschauer; Björn Schwanhäusser; Alexandra Vasile; Yasuhiro Murakawa; Markus Schueler; Noah Youngs; Duncan Penfold-Brown; Kevin Drew; Miha Milek; Emanuel Wyler; Richard Bonneau; Matthias Selbach; Christoph Dieterich; Markus Landthaler
        Molecular cell, 08 Jun. 2012
      • The vital link between the ubiquitin-proteasome pathway and DNA repair: impact on cancer therapy.
        Akira Motegi; Yasuhiro Murakawa; Shunichi Takeda
        Cancer letters, 28 Sep. 2009
      • Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells.
        Yasuhiro Murakawa; Eiichiro Sonoda; Louise J Barber; Weihua Zeng; Kyoko Yokomori; Hiroshi Kimura; Atsuko Niimi; Alan Lehmann; Guang Yu Zhao; Helfrid Hochegger; Simon J Boulton; Shunichi Takeda
        Cancer research, 15 Sep. 2007
      • RAD18 and poly(ADP-ribose) polymerase independently suppress the access of nonhomologous end joining to double-strand breaks and facilitate homologous recombination-mediated repair.
        Alihossein Saberi; Helfrid Hochegger; David Szuts; Li Lan; Akira Yasui; Julian E Sale; Yoshihito Taniguchi; Yasuhiro Murakawa; Weihua Zeng; Kyoko Yokomori; Thomas Helleday; Hirobumi Teraoka; Hiroshi Arakawa; Jean-Marie Buerstedde; Shunichi Takeda
        Molecular and cellular biology, Apr. 2007
      • A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination.
        Guang Yu Zhao; Eiichiro Sonoda; Louise J Barber; Hayato Oka; Yasuhiro Murakawa; Kouichi Yamada; Tsuyoshi Ikura; Xin Wang; Masahiko Kobayashi; Kenichi Yamamoto; Simon J Boulton; Shunichi Takeda
        Molecular cell, 09 Mar. 2007

      Misc.

      • 腎修復を制御する微小環境、三次リンパ組織における細胞間相互作用の解明
        好川 貴久; 小緑 翔太; 小口 綾貴子; 細井 健史; 佐藤 有紀; 村川 泰裕; 柳田 素子
        日本腎臓学会誌, Jul. 2020
      • Involvement of SecA, SecY and AcpP in chromosome partition of Escherichia coli
        Shun Adachi; Yasuhiro Murakawa; Sota Hiraga
        GENES & GENETIC SYSTEMS, Dec. 2014
      • 非ヒト霊長類のトランスクリプトーム・アトラス
        廣瀬直毅; 廣瀬直毅; 依馬正次; 佐々木えりか; GUSEV Oleg; GUSEV Oleg; 河合純; 村川泰裕; 村川泰裕; 川路英哉; 川路英哉; 川路英哉
        日本分子生物学会年会プログラム・要旨集(Web), 2020
      • 白血病を維持する腫瘍エンハンサーの検索
        村川泰裕
        日本応用酵素協会誌, 2021
      • Large-scale electron microscopy-driven next-generation renal pathology.
        小口綾貴子; 小口綾貴子; 村川泰裕; 村川泰裕; 村川泰裕; 村川泰裕; 柳田素子; 久米慧嗣; 久米慧嗣; 久米慧嗣
        月刊腎臓内科, 2021
      • 白血病を維持する腫瘍エンハンサーの検索
        村川泰裕
        日本応用酵素協会誌, 2020
      • GWASで複雑形質を解くぞ!転写性エンハンサーから紐解くGWAS-SNP
        小口綾貴子; 小口綾貴子; 村川泰裕
        実験医学, 2020
      • Large-Area Imaging Technology of Tissue Sections Using SEM and Prospects for Comprehensive Morphological Analysis of Biological Tissues
        久米慧嗣; 久米慧嗣; 久米慧嗣; 久米慧嗣; 村川泰裕
        顕微鏡, 2020
      • CAGE法を用いた骨肉腫細胞株におけるアドリアマイシン耐性の網羅的解析
        佐々恵太; 末原義之; 小口綾貴子; 栗原大聖; 佐野圭; 林大久生; 金栄智; 赤池慶祐; 大久保武人; 高木辰哉; 金子和夫; 村川泰裕; 齋藤剛
        日本整形外科学会雑誌, 2020
      • Elucidation of disease mechanisms by NET-CAGE enhancer profiling.
        石川駿; 佐藤卓; 村川泰裕; 樗木俊聡
        月刊糖尿病・内分泌代謝科, 2020
      • 軟部肉腫におけるCAGE法を用いたプロモーターレベルでの網羅的遺伝子発現プロファイリング
        佐野圭; 末原義之; 小口綾貴子; 林大久生; 佐々恵太; 栗原大聖; 赤池慶祐; 高木辰哉; 金栄智; 大久保武人; 村川泰裕; 金子和夫; 齋藤剛
        日本整形外科学会雑誌, 2020
      • Transcriptional regulatory mechanisms that cause age-related functional changes in microglia
        石川駿; 佐藤卓; 平林茂樹; 山田翔太; 村川泰裕; 樗木俊聡
        日本病理学会会誌, 2020
      • 白血病を維持する腫瘍エンハンサーの検索
        村川泰裕
        日本応用酵素協会誌, 2019
      • 紡錘形細胞肉腫のCAGE法(cap analysis of gene expression法)を用いた網羅的遺伝子発現解析
        佐野圭; 末原義之; 林大久生; 村川泰裕; 栗原大聖; 赤池慶祐; 高木辰哉; 金栄智; 大久保武人; 金子和夫; 齋藤剛
        日本整形外科学会雑誌, 2019
      • 病理形態学の新技術 電子線・X線イメージング技術が織りなす画像ビッグデータ時代の病理学
        久米慧嗣; 久米慧嗣; 久米慧嗣; 田村勝; 小林紀郎; 小林紀郎; 小林紀郎; 小林紀郎; 村川泰裕; 村川泰裕
        病理と臨床, 2019
      • 核酸医薬創薬に資する霊長類オミックスデータベースの構築
        廣瀬直毅; 村川泰裕; 川路英哉; 川路英哉; 川路英哉; 河合純
        日本核酸医薬学会年会講演要旨集, 2019
      • 霊長類DNA/RNAデータベースの構築と医療への応用
        河合純; 廣瀬直毅; 佐野浩美; 岡崎康司; 八木研; 山本由美子; 依馬正次; 清田弥寿成; 築山智之; 中家雅隆; 佐々木えりか; 井上貴史; 渡部聡朗; 榊原康文; JAYAKUMAR Vasanthan; 内藤雄樹; 村川泰裕; 川路英哉; 川路英哉
        Journal of Toxicological Sciences, 2019
      • 広域電子顕微鏡技術による生体組織のビッグデータ解析
        久米慧嗣; 久米慧嗣; 村川泰裕; CHENN Guihua; 小口綾貴子; 田村勝; 小林紀郎; 桝屋啓志; 須賀三雄; 前田光代; 片岡洋祐; 片岡洋祐
        日本病理学会会誌, 2019
      • 非ヒト霊長類ゲノムの非コード領域の機能解析
        廣瀬直毅; 依馬正次; 佐々木えりか; 河合純; 村川泰裕; 川路英哉; 川路英哉; 川路英哉
        日本分子生物学会年会プログラム・要旨集(Web), 2019
      • Hi-Cを用いたカニクイザルとマーモセットの染色体スケールゲノムスキャフォールディング
        門田満隆; 西村理; JAYAKUMAR Vasanthan; 榊原康文; 井上貴史; 佐々木えりか; 依馬正次; 佐野浩美; 廣瀬直毅; 村川泰裕; 川路英哉; 川路英哉; 河合純; 工樂樹洋
        日本分子生物学会年会プログラム・要旨集(Web), 2019
      • 腎の機能成熟と障害抵抗性のパラドックス
        北井悠一朗; 佐藤有紀; 小口綾貴子; 村川泰裕; 柳田素子
        日本腎臓学会誌, 2019
      • 男性ホルモンによる腎成熟制御機構の多層的オミックス解析
        佐藤有紀; 北井悠一郎; 内野詠一郎; 小口綾貴子; 永森收志; 金井好克; 曽我朋義; 村川泰裕; 柳田素子
        日本腎臓学会誌, 2019
      • CAGE法を用いた紡錘形細胞肉腫における網羅的遺伝子発現解析
        佐野圭; 末原義之; 林大久生; 村川泰裕; 栗原大聖; 赤池慶祐; 高木辰哉; 金栄智; 大久保武人; 金子和夫; 齋藤剛
        日本整形外科学会雑誌, 2019
      • Possible role of ZC3HAV1 protein in the post-transcriptional regulation of HTLV-1 RNAs
        宮里パオラ; 宮里パオラ; タン ベンジー; タン ベンジー; 徳永美知代; 徳永美知代; 勝屋弘雄; 勝屋弘雄; 松尾美沙希; 松尾美沙希; 伊東潤平; 村川泰裕; 佐藤賢文; 佐藤賢文
        日本HTLV-1学会学術集会, 2019
      • 腎臓の機能成熟と障害抵抗性のパラドックス
        北井悠一朗; 佐藤有紀; 小口綾貴子; 村川泰裕; 柳田素子
        日本心血管内分泌代謝学会学術総会プログラム及び抄録集, 2019
      • 新規のNET-CAGE-seq法により明らかになる遺伝子発現ネットワークの正体
        村川泰裕
        日本内分泌学会雑誌, 2018
      • ncRNAの医科学と医療 I ゲノム砂漠に潜むエンハンサーからみえる病気のメカニズム
        小口綾貴子; 村川泰裕
        医学のあゆみ, 2018
      • 腎組織のイメージングビッグデータ解析
        村川泰裕; 久米慧嗣; 前田光代; 須賀三雄; 田村勝; 小林紀郎
        日本腎臓学会誌, 2018
      • 腎臓の機能成熟と障害抵抗性のパラドックス
        北井悠一朗; 佐藤有紀; 小口綾貴子; 村川泰裕; 柳田素子
        日本腎臓学会誌, 2018
      • ゲノムデータの再生医療への応用:iPS細胞におけるゲノム変異の解明
        村川泰裕
        日本再生医療学会総会(Web), 2018
      • 次世代ヒト科学を推進するゲノム基盤の構築
        村川泰裕; 廣瀬直毅; 佐野浩美; 川路英哉; 川路英哉; 河合純
        日本分子生物学会年会プログラム・要旨集(Web), 2018
      • 非ヒト霊長類のトランスクリプトーム解析
        廣瀬直毅; 佐野浩美; 八木研; 岡崎康司; 渡部聡朗; 井上貴史; 佐々木えりか; 中家雅隆; 築山智之; 清田弥寿成; 依馬正次; 村川泰裕; 川路英哉; 川路英哉; 河合純
        日本分子生物学会年会プログラム・要旨集(Web), 2018
      • 核酸医薬創薬に資する霊長類オミックスデータベースの構築
        河合純; 川路英哉; 村川泰裕; 佐野浩美; 依馬正次; 清田弥寿成; 築山智之; 中家雅隆; 佐々木えりか; 井上貴史; 渡部聡朗
        日本核酸医薬学会年会講演要旨集, 2018
      • ヒトmRNA/pre-mRNA/lncRNA/pre-lncRNAデータベースの構築
        廣瀬直毅; 内藤雄樹; 村川泰裕; 河合純; 川路英哉; 川路英哉
        日本核酸医薬学会年会講演要旨集, 2018
      • 心筋細胞への高い分化指向性を有するiPS細胞株のスクリーニング法の開発
        大橋文哉; 大橋文哉; 大橋文哉; 宮川繁; 安田智; 三浦巧; 黒田拓也; 齋藤充弘; 八代健太; 増田茂夫; 伊東絵望子; 伊藤昌可; 川路英哉; 村川泰裕; 吉原正仁; 鮫島正; 河合純; 澤芳樹; 佐藤陽治
        日本再生医療学会総会(Web), 2018
      • Cap Analysis of Gene Expression
        平林茂樹; 平林茂樹; 村川泰裕; 村川泰裕
        月刊腎臓内科・泌尿器科, 2017
      • iPS細胞ゲノムにおける点変異のホットスポットの同定
        吉原正仁; 吉原正仁; 荒木良子; 砂山美里; 安倍真澄; 西田幸二; 川路英哉; 川路英哉; 川路英哉; 林崎良英; 村川泰裕; 村川泰裕
        再生医療, 2017
      • トランスクリプトームを高精細・高塩基解像度に読み解く
        村川泰裕
        Genome and Transcriptome toward Future Clinical Innovation. RIKEN Symposium, 2017, 2017
      • CAGE法の新展開~研究から臨床応用にむけて~
        村川泰裕
        日本臨床プロテオーム研究会要旨集(Web), 2017
      • ゲノムワイド解析により明らかになるDicerタンパク質の新たな標的RNAと機能
        村川泰裕
        細胞工学, 2015
      • 活性エンハンサーの高感度ゲノムワイド同定
        村川泰裕
        かなえ医薬振興財団研究業績集(Web), 2015
      • 転写後調節のゲノムワイド解析
        村川泰裕
        日本生化学会大会(Web), 2015
      • 分類不能型免疫不全症を背景に劇症肝炎により肝移植に至った2例
        宮川文; 黒澤学; 村川泰裕; 真鍋俊明
        日本病理学会会誌, 2010
      • ユビキチン化によるDNA修復の制御機構
        茂木章; 村川泰裕; 武田俊一
        実験医学, 2008
      • ユビキチン化によるDNA修復の制御機構
        茂木章; 村川泰裕; 武田俊一
        細胞工学, 2007

      Industrial Property Rights

      • WO2017-130750, JP2017001097, RNAの末端領域に対応する核酸の塩基配列を解読する方法およびDNAエレメントの分析方法
        村川 泰裕; 竹上 雄治郎

      Awards

      • 10 Mar. 2008
        京都大学, 総長賞

      External funds: Kakenhi

      • IgG4関連疾患の創薬ターゲットとなり得る病因関連エンハンサーRNAの探索
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 57:Oral science and related fields
        Kyushu University
        前原 隆
        From 09 Jul. 2021, To 31 Mar. 2024, Granted
        IgG4-RD
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K19607/
      • エンハンサー解析手法を用いた大腸癌リンパ節転移の有無による原発巣の差異の解明
        Grant-in-Aid for Scientific Research (C)
        Basic Section 55020:Digestive surgery-related
        Yokohama City University
        渡邉 純
        From 01 Apr. 2021, To 31 Mar. 2024, Granted
        エンハンサー;CAGEとRNA-seq;大腸癌;リンパ節転移;エンハンサーRNA;CAGE法
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K08738/
      • 機能ゲノミクス解析とハイスループット解析を用いた線維性異形成症新規治療法開発
        Grant-in-Aid for Scientific Research (B)
        Basic Section 57060:Surgical dentistry-related
        Tokyo Dental College
        東 俊文
        From 01 Apr. 2021, To 31 Mar. 2024, Granted
        iPS細胞;GNAS;骨芽細胞分化;Hedghog;骨異形成症;線維化;骨芽細胞;線維性骨異形成症;遺伝性稀少疾患;骨芽細胞分化誘導;FGFG2;McCuneAlbright 症候群;シングルセル解析;ゴーリン症候群
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H03146/
      • International collaboration for comprehensive identification of carcinogenesis-related transcriptional regulatory regions (enhancers)
        Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
        Medium-sized Section 50:Oncology and related fields
        Institute of Physical and Chemical Research
        Yasuhiro Murakawa
        From 27 Oct. 2020, To 31 Mar. 2023, Project Closed
        エンハンサー;発現;早期転写応答;乳がん;c-MYC;ATM;エストロゲン;ノンコーディングRNA;遺伝子発現;発がん;ヒトゲノム科学;遺伝子発現制御;発癌
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20KK0186/
      • Development of a new functional genomics mothod to perform single-cell enhancer identification
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
        Institute of Physical and Chemical Research
        Yasuhiro Murakawa
        From 30 Jul. 2020, To 31 Mar. 2022, Project Closed
        エンハンサー;シングルセル解析;遺伝子発現制御;ヒトゲノム解析;遺伝子発現ネットワーク;バイオインフォマティクス;ゲノムサイエンス;シングルセル;機能性ゲノム学;オミックス解析
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21407/
      • Molecular mechanism of stem cell aging in the bone marrow and muscular tissues
        Grant-in-Aid for Scientific Research (B)
        Basic Section 56020:Orthopedics-related
        Kindai University
        Takeshi Teramura
        From 01 Apr. 2020, To 31 Mar. 2023, Project Closed
        幹細胞;幹細胞老化;再生医療;運動器;遺伝子発現;遺伝子治療;間葉系幹細胞;筋衛星細胞;老化;ゲノム解析;組織幹細胞;転写制御
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H03810/
      • Elucidation for genetic regulation of enhancer expression and interpretation of genetic architecture in autoimmune diseases
        Grant-in-Aid for Scientific Research (A)
        Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
        Institute of Physical and Chemical Research
        寺尾 知可史
        From 01 Apr. 2020, To 31 Mar. 2024, Granted
        エンハンサー;遺伝子発現;ゲノム医療;遺伝多型
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H00462/
      • APOBEC3B-induced genome mutations and its contribution to clonal evolution in cancers
        Grant-in-Aid for Scientific Research (B)
        Basic Section 50010:Tumor biology-related
        Kyoto University
        Akifumi Takaori-Kondo
        From 01 Apr. 2019, To 31 Mar. 2022, Project Closed
        APOBEC;がん;クローン進化;ゲノム変異;シチジン脱アミノ化;C-to-T変異;APOBEC3;癌のクローン進化;癌の多様性;治療抵抗性;マウスモデル;APOBEC signature;CAGE法;シングルセル解析;癌の不均一性
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03502/
      • Mechanism of brain homeostasis dysfunction by spatiotemporal transcriptional dysregulation of microglia.
        Grant-in-Aid for Scientific Research (A)
        Medium-sized Section 49:Pathology, infection/immunology, and related fields
        Tokyo Medical and Dental University
        Toshiaki Ohteki
        From 01 Apr. 2019, To 31 Mar. 2023, Project Closed
        ミクログリア;老化;アルツハイマー病;転写性エンハンサー;NET-CAGE;エンハンサー;NET-CAGE法;活性化エンハンサー;CAGE法;ライフステージ
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H01024/
      • Development of Next-Generation Health Diagnosis Method by Health Informatics Using Ultra-fine Morphological Imaging Data
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
        Institute of Physical and Chemical Research
        Satoshi Kume
        From 29 Jun. 2018, To 31 Mar. 2021, Project Closed
        画像ビッグデータ;電子顕微鏡;画像セグメンテーション;深層学習;未病状態;血液細胞;健康インフォマティクス;概念関係モデル;生物情報学;健康・未病;超微形態解析;BioImageDbs;セマンティックセグメンテーション;画像インフォマティクス;細胞の超微形態;電子顕微鏡解析;画像認識;未病診断;超微細画像;広域電子顕微鏡解析;次世代健康診断法;未病
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19766/
      • Elucidating the mechanism of TWIST1 contribution to OA using genome-wide enhancer analysis
        Grant-in-Aid for Scientific Research (C)
        Basic Section 56020:Orthopedics-related
        Okayama University
        Joe Hasei
        From 01 Apr. 2018, To 31 Mar. 2022, Project Closed
        TWIST1;転写因子;エンハンサー;ゲノムワイド
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K09065/
      • Comprehensive enhancer analysis and molecular pathogenesis of leukemia using our novel technology
        Grant-in-Aid for Scientific Research (A)
        Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
        Institute of Physical and Chemical Research
        Yasuhiro Murakawa
        From 01 Apr. 2018, To 31 Mar. 2021, Project Closed
        白血病;エンハンサー;ゲノム解析技術;バイオマーカー;転写ネットワーク;NET-CAGE;造血器悪性腫瘍;ヒトゲノム科学;ノンコーディングゲノム・RNA;次世代シークエンシング;バイオインフォマティクス;ゲノム科学;遺伝子発現制御;次世代シークエンサー;造血器腫瘍;NET-CAGE法;腫瘍;ゲノム解析
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H03992/
      • Development of a novel NET-CAGE technology to elucidate fundamental transcriptional mechanism underlying tumorigenesis
        Grant-in-Aid for Young Scientists (A)
        Institute of Physical and Chemical Research
        Yasuhiro Murakawa
        From 01 Apr. 2016, To 31 Mar. 2019, Project Closed
        ゲノム科学;転写ネットワーク;バイオインフォマティクス;エンハンサー;CAGE解析;NET-CAGE法;次世代シークエンシング;腫瘍;遺伝子発現制御;次世代シークエンサー;造血器腫瘍
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H06153/
      • Development of personalized medicine for lung cancer using next-generation transcriptome
        Grant-in-Aid for Scientific Research (B)
        Basic Section 49020:Human pathology-related
        Juntendo University
        林 大久生
        From 01 Apr. 2022, To 31 Mar. 2026, Granted
        肺癌;CAGE;トランスクリプトーム解析;エンハンサー;肺がん;個別化医療
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H02842/
      • 口腔扁平苔癬の創薬ターゲットの探索～病因T細胞と関連エンハンサーRNAの同定～
        Grant-in-Aid for Challenging Research (Pioneering)
        Medium-sized Section 57:Oral science and related fields
        Kyushu University
        中村 誠司
        From 30 Jun. 2022, To 31 Mar. 2025, Granted
        口腔扁平苔癬;口腔扁平上皮癌;シングルセルRNA;T細胞;エンハンサーRNA;シングルセル
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K18401/
      • ゲノムエンハンサーの作動原理の解明
        Grant-in-Aid for JSPS Fellows
        Basic Section 43050:Genome biology-related
        Kyoto University
        From 28 Sep. 2022, To 31 Mar. 2025, Granted
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22F22079/
      • ゲノムエンハンサーの作動原理の解明
        Grant-in-Aid for JSPS Fellows
        Basic Section 43050:Genome biology-related
        Kyoto University
        村川 泰裕
        From 08 Mar. 2023, To 31 Mar. 2025, Granted
        エンハンサー
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KF0209/
      • TWIST1発現に基づく高組織寄与MSCを用いた新しい組織再生医療と新規MSCマーカーの開発
        Grant-in-Aid for Scientific Research (B)
        Basic Section 56020:Orthopedics-related
        Kindai University
        寺村 岳士
        From 01 Apr. 2023, To 31 Mar. 2026, Granted
        間葉系幹細胞;糖鎖解析;細胞表面抗原;未分化維持機構;scRNAseq
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H03034/
      • 次世代遺伝子発現解析法に立脚したシーケンスレスながん分子サブタイプ規定法の開発
        Grant-in-Aid for Scientific Research (A)
        Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
        Nagoya University
        赤松 秀輔
        From 01 Apr. 2023, To 31 Mar. 2027, Granted
        前立腺癌;分子サブタイプ;ロングリードRNAシーケンス;単一細胞核シーケンス;多重免疫染色
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H00435/
      • Basic research for clinical application of patient-derived xenograft avatar model by zebrafish
        Grant-in-Aid for Scientific Research (B)
        Basic Section 56030:Urology-related
        Mie University
        井上 貴博
        From 01 Apr. 2024, To 31 Mar. 2027, Granted
        膀胱癌;患者由来異種移植モデル;ゼブラフィッシュ;シスプラチン;耐性機序
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02576/
      • Development of stemness specific markers in MSCs based on activity of transcription factor TWIST1
        Grant-in-Aid for Scientific Research (B)
        Basic Section 56020:Orthopedics-related
        Kindai University
        寺村 岳士
        From 01 Apr. 2023, To 31 Mar. 2026, Granted
        再生医療;間葉系幹細胞;転写因子;糖鎖解析;細胞表面抗原;未分化維持機構;scRNAseq
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27725/
      • Development of personalized medicine for lung cancer using next-generation transcriptome
        Grant-in-Aid for Scientific Research (B)
        Basic Section 49020:Human pathology-related
        Juntendo University
        林 大久生
        From 01 Apr. 2022, To 31 Mar. 2026, Granted
        がん;トランスクリプトーム;肺がん;遺伝子;肺癌;CAGE;トランスクリプトーム解析;エンハンサー;個別化医療
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24104/
      list
        Last Updated :2024/11/26

        Education

        Participation in PhD Defense

        • Delving into gene-set multiplex networks facilitated by a k-nearest neighbor-based measure of similarity
          CHENG ZHENG, Graduate School of Medicine, Chief Examiner
          25 Mar. 2024
        • Deep generative design of RNA family sequences
          SUMI SHUNSUKE, Graduate School of Medicine, Chief Examiner
          25 Mar. 2024
        • Synthetic circular RNA switches and circuits that control protein expression in mammalian cells
          KAMEDA SHIGETOSHI, Graduate School of Medicine, Chief Examiner
          25 Mar. 2024
        • Leveraging genomics and proteomics to identify therapeutic targets for COVID-19 and cardiometabolic diseases
          YOSHIJI SATOSHI, Graduate School of Medicine, Chief Examiner
          25 Mar. 2024
        • Comprehensive analysis of full-length transcripts reveals novel splicing abnormalities and oncogenic transcripts in liver cancer
          KIYOSE HIROKI, Graduate School of Medicine, Chief Examiner
          23 May 2023
        • Conserved Double Translation Initiation Site for Δ160p53 Protein Hints at Isoform’s Key Role in Mammalian Physiology
          MARIA JOSE LOPEZ INIESTA, Graduate School of Medicine, Chief Examiner
          24 Nov. 2023
        • RNA-seq-based miRNA signature as an independent predictor of relapse in pediatric B-cell acute lymphoblastic leukemia
          KUBOTA HIROHITO, Graduate School of Medicine, Chief Examiner
          25 Mar. 2024
        • Evolutionary histories of breast cancer and related clones
          NISHIMURA　TOMOMI, Graduate School of Medicine, Chief Examiner
          25 Mar. 2024
        • A large-scale targeted proteomics of plasma extracellular vesicles shows utility for prognosis prediction subtyping in colorectal cancer
          KASAHARA KEIKO, Graduate School of Medicine, Sub-chief Examiner
          23 May 2023
        • Combined landscape of single-nucleotide variants and copy number alterations in clonal hematopoiesis
          SAIKI RYUNOSUKE, Graduate School of Medicine, Chief Examiner
          23 Mar. 2023
        • Genome-wide Survival Analysis for Macular Neovascularization Development in Central Serous Chorioretinopathy Revealed Shared Genetic Susceptibility with Polypoidal Choroidal Vasculopathy
          MORI YUKI, Graduate School of Medicine, Chief Examiner
          23 Mar. 2023
        • Expansion of gastric intestinal metaplasia with copy number aberrations contributes to field cancerization
          KUMAGAI KEN, Graduate School of Medicine, Chief Examiner
          25 Jul. 2022
        • Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids
          SUEZAWA TAKAHIRO, Graduate School of Medicine, Chief Examiner
          26 Sep. 2022
        • Cutaneous Liver X Receptor Activation Prevents the Formation of Imiquimod-Induced Psoriatic Dermatitis
          OTSUKA MASAYUKI, Graduate School of Medicine, Chief Examiner
          23 Mar. 2022
        • Prognostic stratification for IDH-wild-type lower-grade astrocytoma by Sanger sequencing and copy-number alteration analysis with MLPA
          MAKINO YASUHIDE, Graduate School of Medicine, Chief Examiner
          23 Mar. 2022
        • Clinical impact of detecting low-frequency variants in cell-free DNA on treatment of castration-resistant prostate cancer
          MIZUNO KEI, Graduate School of Medicine, Chief Examiner
          23 Mar. 2022
        • In silico analysis of inner ear development using public whole embryonic body single-cell RNA-sequencing data
          YAMAMOTO RYOSUKE, Graduate School of Medicine, Chief Examiner
          23 Mar. 2022
        • Comparative evaluation of the extraction and analysis of urinary phospholipids and lysophospholipids using MALDI-TOF/MS
          LI XIN, Graduate School of Medicine, Chief Examiner
          26 Jul. 2021
        • HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis
          TAKAHASHI SATOSHI, Graduate School of Medicine, Chief Examiner
          23 Mar. 2022
        • Trp53 Mutation in Keratin 5 (Krt5)-Expressing Basal Cells Facilitates the Development of Basal Squamous-Like Invasive Bladder Cancer in the Chemical Carcinogenesis of Mouse Bladder
          MASUDA NORIHIKO, Graduate School of Medicine, Chief Examiner
          24 Jan. 2022

        Part-time lecturer

        • From 01 Apr. 2024, To 31 Mar. 2025
          滋賀医科大学

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