Basic Information

Faculty

• 薬学部

Concurrent Affiliation

• Graduate School of Pharmaceutical Sciences, 医薬創成情報科学専攻 医薬創成情報科学, 教授

Professional Memberships

• The Japanese Peptide Society
• The Society of Synthetic Organic Chemistry, Japan
• The Pharmaceutical Society of Japan

Academic Degree

• 修士（薬学）(京都大学)
• 博士（薬学）(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院薬学研究科修士課程薬学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 京都大学, 薬学部製薬化学科, 卒業

High School

• High School

  函館ラ・サール高等学校

Research History

• From Apr. 2015, To Mar. 2019

  Kyoto University, ILAS/Graduate School of Pharmceutical Sciences, Professor
• From Apr. 2019, To Present

  Institute for Liberal Arts and Sciences/Graduate School of Pharmaceutical Sciences, Kyoto University, Professor
• From 01 Apr. 2008

  Graduate School of Pharmaceutical Sciences, Kyoto University, Associate Professor
• From 01 Jul. 2005

  Graduate School of Pharmaceutical Sciences, Kyoto University, Associate Professor
• From 16 Sep. 1999

  Graduate School of Pharmaceutical Sciences, Osaka University, Assistant Professor
• From 01 Jan. 1999

  Japan Society for the Promotion of Science, JSPS Research Fellow

Language of Instruction

• English

ID,URL

• J-Global ID

  200901045381507655

• External link

  http://www.pharm.kyoto-u.ac.jp//seizo/

Website(s) (URL(s))

• http://www.pharm.kyoto-u.ac.jp//seizo/

researchmap URL

• https://researchmap.jp/read0057482

Research

Research Topics, Overview of the research

• Research Topics

  Direct construction of complex scaffolds and its medicinal applications

• Overview of the research

  Improvement of reaction efficiency by development of novel atom-economical cascade reactions, synthetic studies of bioactive compounds, and their medicinal application studies are conducted.

Research Interests

• Sythetic Organic Chemistry
• Natural Product Chemistry
• Medicinal Chemistry
• Cascade reactions

Research Areas

• Life sciences, Pharmaceuticals - chemistry and drug development
• Life sciences, Bioorganic chemistry

Papers

• Maternal progesterone and adipose mPRε in pregnancy regulate the embryonic nutritional state

  Keita Watanabe; Mayu Yamano; Junki Miyamoto; Ryuji Ohue-Kitano; Yuki Masujima; Daiki Sasahara; Yuki Mouri; Nozomu Kono; Shunsuke Inuki; Fumitaka Osakada; Kentaro Nagaoka; Junken Aoki; Yuki Sugiura; Hiroaki Ohno; Eiji Kondoh; Ikuo Kimura

  Cell Reports, Mar. 2025

  Access this paper :

  
• A General Nitrene Transfer to Sulfides Enabled by Visible-Light-Mediated Triplet Energy Transfer to Sulfonyl Azides

  Hiroaki Ohno

  ChemRxiv, 2024

  
• A General Nitrene Transfer to Sulfides Enabled by Visible-Light-Mediated Triplet Energy Transfer to Sulfonyl Azides

  Hiroaki Ohno

  ChemRxiv, 2024

  
• Development of Ribityllumazine Analogs as Mucosal-associated Invariant T Cell Activators

  Hiroaki Ohno

  ChemRxiv, 2024

  
• Recent advances in the construction of polycyclic compounds by palladium-catalyzed atom-economical cascade reactions

  Ohno, H.

  Asian Journal of Organic Chemistry, 2013

  
• Regiospecific ring-opening reactions of β-aziridinyl ct, β-enoates with acids: Application to the stereoselective synthesis of a couple of diastereoisomeric (Zi)-alkene dipeptide isosteres from a single β-aziridinyl a, β-enoate and to the convenient preparation of amino alcohols bearing a, β-unsaturated ester groups

  Tamamura, H.; Yamashita, M.; Nakajima, Y.; Sakano, K.; Otaka, A.; Ohno, H.; Ibuka, T.; Fujii, N.

  Journal of the Chemical Society - Perkin Transactions 1, 1999

  
• Visible light-mediated photocatalytic coupling between tetrazoles and carboxylic acids for biomolecule labelling

  Takuro Matsuoka; Ryosuke Takasaki; Hiroki Akiba; Kosuke Ogata; Akira Hattori; Norihito Arichi; Hideaki Kakeya; Sho Yamasaki; Yasushi Ishihama; Hiroaki Ohno; Shinsuke Inuki

  Chemical Communications, 2025

  
• Visible light-mediated photocatalytic coupling between tetrazoles and carboxylic acids for protein and cell labelling

  Takuro Matsuoka; Ryosuke Takasaki; Hiroki Akiba; Kosuke Ogata; Akira Hattori; Norihito Arichi; Hideaki Kakeya; Sho Yamasaki; Yasushi Ishihama; Hiroaki Ohno; Shinsuke Inuki

  29 Aug. 2024

  
• Elucidation of Postfusion Structures of the Measles Virus F Protein for the Structure-Based Design of Fusion Inhibitors.

  Aoi Takahara; Toru Nakatsu; Kazushige Hirata; Hironori Hayashi; Kumi Kawaji; Keisuke Aoki; Shinsuke Inuki; Hiroaki Ohno; Hiroaki Kato; Eiichi Kodama; Shinya Oishi

  Journal of medicinal chemistry, 31 Jan. 2025

  
• Receptor-independent regulation of Gα13 by alpha-1-antitrypsin C-terminal peptides

  Yonghak Park; Shigeyuki Matsumoto; Kosuke Ogata; Biao Ma; Ryo Kanada; Yuta Isaka; Norihito Arichi; Xiaowen Liang; Ritsuko Maki; Tohru Kozasa; Yasushi Okuno; Hiroaki Ohno; Yasushi Ishihama; Fumiko Toyoshima

  Journal of Biological Chemistry, Dec. 2024

  
• Generation of antagonistic biparatopic anti-CD30 antibody from an agonistic antibody by precise epitope determination and utilization of structural characteristics of CD30 molecule

  Hiroki Akiba; Tomoko Ise; Reiko Satoh; Yasuhiro Abe; Kouhei Tsumoto; Hiroaki Ohno; Haruhiko Kamada; Satoshi Nagata

  03 Aug. 2024

  
• Development of Ribityllumazine Analogue as Mucosal-Associated Invariant T Cell Ligands.

  Ryosuke Takasaki; Emi Ito; Masamichi Nagae; Yuki Takahashi; Takuro Matsuoka; Wakana Yasue; Norihito Arichi; Hiroaki Ohno; Sho Yamasaki; Shinsuke Inuki

  Journal of the American Chemical Society, 21 Oct. 2024

  
• Chemical Synthesis of Interleukin-6 for Mirror-Image Screening.

  Keisuke Aoki; Kayuu Maeda; Shinsuke Inuki; Hiroaki Ohno; Motohiro Nonaka; Shinya Oishi

  Bioconjugate chemistry, 21 Aug. 2024

  
• Sucrose-preferring gut microbes prevent host obesity by producing exopolysaccharides

  Ikuo Kimura; Hidenori Shimizu; Junki Miyamoto; Keiko Hisa; Ryuji Ohue-Kitano; Hiromi Takada; Mayu Yamano; Akari Nishida; Daiki Sasahara; Yuki Masujima; Keita Watanabe; Syota Nishikawa; Sakura Takahashi; Takako Ikeda; Yuya Nakajima; Naofumi Yoshida; Chiaki Matsuzaki; Takuya Kageyama; Ibuki Hayashi; Akari Matsuki; Ryo Akashi; Seiichi Kitahama; Masako Ueyama; Takumi Murakami; Shinsuke Inuki; Junichiro Irie; Noriko Satoh-Asahara; Hirokazu Toju; Hiroshi Mori; Shinji Nakaoka; Tomoya Yamashita; Atsushi Toyoda; Kenji Yamamoto; Hiroaki Ohno; Takane Katayama; Hiroshi Itoh

  16 Feb. 2024

  
• Compounds Designs of CK2α Inhibitors Derived from Virtual Screening Hit Compounds by Computational Chemistry with Crystallography

  Shinya Nakamura; Keiji Nishiwaki; Masato Tsuyuguchi; Takayoshi Kinoshita; Shinya Oishi; Hiroaki Ohno; Isao Nakanishi

  Chemical and Pharmaceutical Bulletin, 01 Sep. 2024

  
• Approach to Spirocyclohexadienes via Visible Light‐Mediated ipso‐Cyclization of Amino Acid Derivatives with N‐(2‐Phenyl)benzoyl Groups

  Yuki Yoshida; Haruka Takeuchi; Norihito Arichi; Shinya Oishi; Hiroaki Ohno; Shinsuke Inuki

  Asian Journal of Organic Chemistry, 28 May 2024

  
• Total Synthesis of Dictyodendrins A–F by the Gold-Catalyzed Cascade Cyclization of Conjugated Diyne with Pyrrole

  Junpei Matsuoka; Shinsuke Inuki; Yuka Matsuda; Yoichi Miyamoto; Mayumi Otani; Masahiro Oka; Shinya Oishi; Hiroaki Ohno

  Chemistry - A European Journal, 2020

  
• Construction of the Akuammiline Alkaloid Core Structure via Stereoselective E-Ring Formation.

  Naoki Hashimoto; Junichi Taguchi; Takumi Kasagi; Norihito Arichi; Shinsuke Inuki; Hiroaki Ohno

  The Journal of organic chemistry, 01 Jul. 2024

  
• Synthesis of Sulfilimines via Visible-Light-Mediated Triplet Energy Transfer to Sulfonyl Azides.

  Norihito Arichi; Tsuyoshi Amano; Shuhan Wu; Shinsuke Inuki; Hiroaki Ohno

  Chemistry (Weinheim an der Bergstrasse, Germany), 24 Jun. 2024

  
• Engineering a Low-Immunogenic Mirror-Image VHH against Vascular Endothelial Growth Factor.

  Keisuke Aoki; Katsuaki Higashi; Sakiho Oda; Asako Manabe; Kayuu Maeda; Jyoji Morise; Shogo Oka; Shinsuke Inuki; Hiroaki Ohno; Shinya Oishi; Motohiro Nonaka

  ACS chemical biology, 17 May 2024

  
• Mirror-Image Human Serum Albumin Domain III as a Tool for Analyzing Site II-Dependent Molecular Recognition

  Naoya Iwamoto; Takuma Kai; Shinsuke Inuki; Hiroaki Ohno; Hitoshi Maeda; Hiroshi Watanabe; Toru Maruyama; Shinya Oishi

  Bioconjugate Chemistry, 23 May 2024

  
• Structure-activity relationship studies of tetrahydroquinolone derivatives as GPR41 modulators

  Shinsuke Inuki; Junki Miyamoto; Naoki Hashimoto; Hidenori Shimizu; Hitomi Tabuchi; Atsuko Kawai; Luca C. Greiner; Ikuo Kimura; Hiroaki Ohno

  Bioorganic & Medicinal Chemistry Letters, Jul. 2024

  
• Gold(I)-Catalyzed Cascade Cyclization of Alkynyl Indoles for the Stereoselective Construction of the Quaternary Carbon Center of Akuammiline Alkaloids

  Hashimoto, N.; Taguchi, J.; Arichi, N.; Inuki, S.; Ohno, H.

  Journal of Organic Chemistry, 2023

  Access this paper :

  
• Design and Synthesis of Monobody Variants with Low Immunogenicity

  Iwamoto, N.; Sato, Y.; Manabe, A.; Inuki, S.; Ohno, H.; Nonaka, M.; Oishi, S.

  ACS Medicinal Chemistry Letters, 2023

  
• Synthesis of the full-length hepatitis B virus core protein and its capsid formation.

  Keisuke Aoki; Shugo Tsuda; Naoko Ogata; Michiyo Kataoka; Jumpei Sasaki; Shinsuke Inuki; Hiroaki Ohno; Koichi Watashi; Taku Yoshiya; Shinya Oishi

  Organic & biomolecular chemistry, 13 Mar. 2024

  
• Synthesis of labionin and avionin precursors via a nitrogen-centred-radical-triggered 1,5-HAT reaction of Tris derivatives.

  Ayuta Yamaguchi; Naoki Obiya; Norihito Arichi; Shinya Oishi; Hiroaki Ohno; Shinsuke Inuki

  Organic & biomolecular chemistry, 06 Mar. 2024

  
• Synthetic studies on the extracellular domain of the T cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) using Trt-K10 solubilizing tags.

  Naoya Iwamoto; Jumpei Sasaki; Saya Ohno; Keisuke Aoki; Yusuke Usui; Shinsuke Inuki; Hiroaki Ohno; Shinya Oishi

  Bioorganic & medicinal chemistry, 01 Feb. 2024

  
• Mirror-Image Single-Domain Antibody for a Novel Nonimmunogenic Drug Scaffold.

  Keisuke Aoki; Asako Manabe; Hiroyuki Kimura; Yohei Katoh; Shinsuke Inuki; Hiroaki Ohno; Motohiro Nonaka; Shinya Oishi

  Bioconjugate chemistry, 26 Oct. 2023

  
• Design of Synthetic Surrogates for the Macrolactone Linker Motif in Coibamide A

  Rikito Suzuki; Daphne R. Mattos; Takashi Kitamura; Rina Tsujioka; Kazuya Kobayashi; Shinsuke Inuki; Hiroaki Ohno; Jane E. Ishmael; Kerry L. McPhail; Shinya Oishi

  ACS Medicinal Chemistry Letters, 19 Sep. 2023, Peer-reviewed

  
• Gold(I)‐Catalyzed Bis‐Cyclization of Allenynes for the Synthesis of Strained and Planar Polycyclic Compounds

  Hitomi Tsuno; Jingfeng Shen; Hiroki Komatsu; Norihito Arichi; Shinsuke Inuki; Hiroaki Ohno

  Angewandte Chemie International Edition, 28 Aug. 2023, Peer-reviewed

  
• Construction of a Bicyclo[2.2.2]octene Skeleton via a Visible-Light-Mediated Radical Cascade Reaction of Amino Acid Derivatives with N-(2-Phenyl)benzoyl Groups

  Yoshida, Y.; Takeuchi, H.; Nakagawa, K.; Fujii, T.; Arichi, N.; Oishi, S.; Ohno, H.; Inuki, S.

  Organic Letters, 07 Jul. 2023, Peer-reviewed

  
• Alkoxymigration onto α‐Imino Gold Carbenes for Constructing Propellane‐Type Indolines

  Luca C. Greiner; Norihito Arichi; Shinsuke Inuki; Hiroaki Ohno

  Asian Journal of Organic Chemistry, Jul. 2023

  Access this paper :

  
• Establishment of an MR1 Presentation Reporter Screening System and Identification of Phenylpropanoid Derivatives as MR1 Ligands.

  Takuro Matsuoka; Akira Hattori; Shinya Oishi; Mitsugu Araki; Biao Ma; Toshiki Fujii; Norihito Arichi; Yasushi Okuno; Hideaki Kakeya; Sho Yamasaki; Hiroaki Ohno; Shinsuke Inuki

  Journal of medicinal chemistry, 14 Sep. 2023

  
• Archaeal Glycerolipids Are Recognized by C-Type Lectin Receptor Mincle.

  Shiori Oka; Miyuki Watanabe; Emi Ito; Ami Takeyama; Takuro Matsuoka; Masatomo Takahashi; Yoshihiro Izumi; Norihito Arichi; Hiroaki Ohno; Sho Yamasaki; Shinsuke Inuki

  Journal of the American Chemical Society, 23 Aug. 2023

  
• A Proximity‐Induced Fluorogenic Reaction Triggered by Antibody–Antigen Interactions with Adjacent Epitopes

  Kentaro Nishiyama; Hiroki Akiba; Satoshi Nagata; Kouhei Tsumoto; Haruhiko Kamada; Hiroaki Ohno

  Angewandte Chemie International Edition, 31 May 2023, Peer-reviewed, Last author, Corresponding author

  Access this paper :

  
• Development of a 1:1-binding biparatopic anti-TNFR2 antagonist by epitope selection

  Hiroki Akiba; Junso Fujita; Tomoko Ise; Kentaro Nishiyama; Tomoko Miyata; Takayuki Kato; Keiichi Namba; Hiroaki Ohno; Haruhiko Kamada; Satoshi Nagata; Kouhei Tsumoto

  Communications Biology, 16 Dec. 2022

  
• Host metabolic benefits of prebiotic exopolysaccharides produced by Leuconostoc mesenteroides

  Junki Miyamoto; Hidenori Shimizu; Keiko Hisa; Chiaki Matsuzaki; Shinsuke Inuki; Yuna Ando; Akari Nishida; Ayano Izumi; Mayu Yamano; Chihiro Ushiroda; Junichiro Irie; Takane Katayama; Hiroaki Ohno; Hiroshi Itoh; Kenji Yamamoto; Ikuo Kimura

  Gut Microbes, 31 Dec. 2023

  Access this paper :

  
• Gold(I)‐Catalyzed Benzylic C(sp 3 )−H Functionalizations: Divergent Synthesis of Indole[ a ]‐ and [ b ]‐Fused Polycycles

  Luca C. Greiner; Norihito Arichi; Shinsuke Inuki; Hiroaki Ohno

  Angewandte Chemie International Edition, 16 Jan. 2023, Peer-reviewed, Last author, Corresponding author

  Access this paper :

  
• Discovery of Bis-sulfonamides as Novel Inhibitors of Mitochondrial NADH-Quinone Oxidoreductase (Complex I)

  Atsuhito Tsuji; Takahiro Masuya; Norihito Arichi; Shinsuke Inuki; Masatoshi Murai; Hideto Miyoshi; Hiroaki Ohno

  ACS Medicinal Chemistry Letters, 24 Jan. 2023, Last author, Corresponding author

  Access this paper :

  
• The identification of novel small extracellular vesicle (sEV) production modulators using luciferase‐based sEV quantification method

  Aki Yamamoto; Yuki Takahashi; Shinsuke Inuki; Shumpei Nakagawa; Kodai Nakao; Hiroaki Ohno; Masao Doi; Yoshinobu Takakura

  Journal of Extracellular Biology, 27 Sep. 2022

  Access this paper :

  
• Front Cover: Access to Indole‐Fused Benzannulated Medium‐Sized Rings through a Gold(I)‐Catalyzed Cascade Cyclization of Azido‐Alkynes (Chem. Eur. J. 51/2021)

  Luca C. Greiner; Shinsuke Inuki; Norihito Arichi; Shinya Oishi; Rikito Suzuki; Tomohiro Iwai; Masaya Sawamura; A. Stephen K. Hashmi; Hiroaki Ohno

  Chemistry – A European Journal, 09 Sep. 2021, Last author, Corresponding author

  
• コンドロイチン硫酸とsiRNAリポプレックスの連続投与におけるsiRNAの生体内分布と遺伝子発現抑制効果に及ぼす正電荷リポソームの正電荷脂質の影響

  服部 喜之; 中村 麻里; 竹内 のぞみ; 吉池 悠貴; 田口 将光; 大野 浩章; 尾崎 惠一; 大西 啓

  日本薬学会年会要旨集, Mar. 2018

  
• Novel anti-flavivirus drugs targeting the nucleolar distribution of core protein.

  Makoto Tokunaga; Yoichi Miyamoto; Tatsuya Suzuki; Mayumi Otani; Shinsuke Inuki; Tsuyoshi Esaki; Chioko Nagao; Kenji Mizuguchi; Hiroaki Ohno; Yoshihiro Yoneda; Toru Okamoto; Masahiro Oka; Yoshiharu Matsuura

  Virology, Feb. 2020, Peer-reviewed

  
• P-423 Structure-Activity Relationship Studies on Cyclic Peptide-Based CXCR4 Antagonists

  Ueda Satoshi; Oishi Shinya; Wang Zi-xuan; Araki Takanobu; Tamamura Hirokazu; Ohno Hiroaki; Nakashima Hideki; Peiper Stephen C.; Fujii Nobutaka

  International Symposium on the Chemistry of Natural Products, 23 Jul. 2006

  
• P-485 Development of Synthetic Methodology toward (Z)-Fluoroalkene Dipeptide Isosteres Based on the Concept of Organometalic-Mediated C-F Bond Cleavage

  Narumi T.; Tomita K.; Niida A.; Kodera Y.; Oishi S.; Ohno H.; Fujii N.

  International Symposium on the Chemistry of Natural Products, 23 Jul. 2006

  
• 102(P-59) The First Total Synthesis of (±)-Scopadulin

  Rahman S. M. Abdur; Ohno Hiroaki; Murata Takashi; Yoshino Hitoshi; Satoh Norifumi; Murakami Kazuo; Patra Debasis; Iwata Chuzo; Maezaki Naoyoshi; Tanaka Tetsuaki

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Sep. 2001

  
• Identification of a Novel Indoleamine 2,3-Dioxygenase Inhibitor Bearing an Eight-Membered Ring Fused Indole Scaffold and Its Structure-Activity Relationship

  Shinsuke Inuki; Hiroaki Ohno; Ayuta Yamaguchi; Katsumi Ohta; Shinya Oishi; Akira Asai

  HETEROCYCLES, 2021, Last author, Corresponding author

  
• Chemical Synthesis and Evaluation of Exopolysaccharide Fragments Produced by Leuconostoc mesenteroides Strain NTM048.

  Shinsuke Inuki; Hitomi Tabuchi; Chiaki Matsuzaki; Yasunori Yonejima; Keiko Hisa; Ikuo Kimura; Kenji Yamamoto; Hiroaki Ohno

  Chemical & pharmaceutical bulletin, 2022, Last author, Corresponding author

  
• Construction of Tricyclic Nitrogen Heterocycles by a Gold(I)-Catalyzed Cascade Cyclization of Allenynes and Application to Polycyclic π-Electron Systems.

  Hiroki Komatsu; Takaya Ikeuchi; Hitomi Tsuno; Norihito Arichi; Kosuke Yasui; Shinya Oishi; Shinsuke Inuki; Aiko Fukazawa; Hiroaki Ohno

  Angewandte Chemie (International ed. in English), 20 Dec. 2021, Last author, Corresponding author

  Access this paper :

  
• Azido-Alkynes in Gold(I)-Catalyzed Indole Syntheses.

  Luca C Greiner; Junpei Matsuoka; Shinsuke Inuki; Hiroaki Ohno

  Chemical record (New York, N.Y.), Dec. 2021, Invited, Last author, Corresponding author

  Access this paper :

  
• Production of IgG1-based bispecific antibody without extra cysteine residue via intein-mediated protein trans-splicing.

  Hiroki Akiba; Tomoko Ise; Satoshi Nagata; Haruhiko Kamada; Hiroaki Ohno; Kouhei Tsumoto

  Scientific reports, 30 Sep. 2021

  Access this paper :

  
• Design of Coibamide A Mimetics with Improved Cellular Bioactivity

  Kitamura, T.; Suzuki, R.; Inuki, S.; Ohno, H.; McPhail, K.L.; Oishi, S.

  ACS Medicinal Chemistry Letters, 2022

  Access this paper :

  
• Access to Indole‐Fused Benzannulated Medium‐Sized Rings through a Gold(I)‐Catalyzed Cascade Cyclization of Azido‐Alkynes

  Luca C. Greiner; Shinsuke Inuki; Norihito Arichi; Shinya Oishi; Rikito Suzuki; Tomohiro Iwai; Masaya Sawamura; A. Stephen K. Hashmi; Hiroaki Ohno

  Chemistry – A European Journal, 09 Sep. 2021, Last author, Corresponding author

  
• Nonbiomimetic total synthesis of indole alkaloids using alkyne-based strategies.

  Hiroaki Ohno; Shinsuke Inuki

  Organic & biomolecular chemistry, 28 Apr. 2021, Invited, Lead author, Corresponding author

  Access this paper :

  
• The effects of 5-OP-RU stereochemistry on its stability and MAIT-MR1 axis.

  Takuro Matsuoka; Chihiro Motozono; Akira Hattori; Hideaki Kakeya; Sho Yamasaki; Shinya Oishi; Hiroaki Ohno; Shinsuke Inuki

  Chembiochem : a European journal of chemical biology, 15 Feb. 2021, Corresponding author

  
• Total syntheses of myriocin, mycestericins and sphingofungin E: sphingosine analogues containing a β, β¤-dihydroxy α-amino acid framework

  Inuki, S.; Ohno, H.

  Chemistry Letters, 2021, Invited, Last author

  
• Correction to "Gold(I)-Catalyzed Cascade Cyclization of Anilines with Diynes: Controllable Formation of Eight-Membered Ring-Fused Indoles and Propellane-Type Indolines".

  Ayuta Yamaguchi; Shinsuke Inuki; Yusuke Tokimizu; Shinya Oishi; Hiroaki Ohno

  The Journal of organic chemistry, 01 Jan. 2021

  
• Total Synthesis of Zephycarinatines via Photocatalytic Reductive Radical ipso-Cyclization.

  Haruka Takeuchi; Shinsuke Inuki; Kohei Nakagawa; Takaaki Kawabe; Atsuhiko Ichimura; Shinya Oishi; Hiroaki Ohno

  Angewandte Chemie (International ed. in English), 16 Nov. 2020

  Access this paper :

  
• Total Synthesis of Dictyodendrins A-F by the Gold-Catalyzed Cascade Cyclization of Conjugated Diyne with Pyrrole.

  Junpei Matsuoka; Shinsuke Inuki; Yuka Matsuda; Yoichi Miyamoto; Mayumi Otani; Masahiro Oka; Shinya Oishi; Hiroaki Ohno

  Chemistry (Weinheim an der Bergstrasse, Germany), 01 Sep. 2020

  Access this paper :

  
• Total Synthesis of (+)-Polyoxamic Acid via Visible-Light-Mediated Photocatalytic β-Scission and 1,5-Hydrogen Atom Transfer of Glucose Derivative.

  Takuro Matsuoka; Shinsuke Inuki; Takashi Miyagawa; Shinya Oishi; Hiroaki Ohno

  The Journal of organic chemistry, 19 Jun. 2020, Peer-reviewed

  
• Correction to Construction of the Pyrrolo[2,3-d]carbazole Core of Spiroindoline Alkaloids by Gold-Catalyzed Cascade Cyclization of Ynamide.

  Junpei Matsuoka; Hiroshi Kumagai; Shinsuke Inuki; Shinya Oishi; Hiroaki Ohno

  The Journal of organic chemistry, 06 Mar. 2020, Peer-reviewed

  
• Maternal gut microbiota in pregnancy influences offspring metabolic phenotype in mice.

  Ikuo Kimura; Junki Miyamoto; Ryuji Ohue-Kitano; Keita Watanabe; Takahiro Yamada; Masayoshi Onuki; Ryo Aoki; Yosuke Isobe; Daiji Kashihara; Daisuke Inoue; Akihiko Inaba; Yuta Takamura; Satsuki Taira; Shunsuke Kumaki; Masaki Watanabe; Masato Ito; Fumiyuki Nakagawa; Junichiro Irie; Hiroki Kakuta; Masakazu Shinohara; Ken Iwatsuki; Gozoh Tsujimoto; Hiroaki Ohno; Makoto Arita; Hiroshi Itoh; Koji Hase

  Science (New York, N.Y.), 28 Feb. 2020, Peer-reviewed

  
• Gold(I)-Catalyzed Cascade Cyclization of Anilines with Diynes: Controllable Formation of Eight-Membered Ring-Fused Indoles and Propellane-Type Indolines.

  Ayuta Yamaguchi; Shinsuke Inuki; Yusuke Tokimizu; Shinya Oishi; Hiroaki Ohno

  The Journal of organic chemistry, 21 Feb. 2020, Peer-reviewed

  Access this paper :

  
• Construction of the Pyrrolo[2,3-d]carbazole Core of Spiroindoline Alkaloids by Gold-Catalyzed Cascade Cyclization of Ynamide.

  Junpei Matsuoka; Hiroshi Kumagai; Shinsuke Inuki; Shinya Oishi; Hiroaki Ohno

  The Journal of organic chemistry, 19 Jul. 2019, Peer-reviewed

  Access this paper :

  
• Construction of Quaternary Carbon Stereocenter of α-Tertiary Amine through Remote C-H Functionalization of Tris Derivatives: Enantioselective Total Synthesis of Myriocin.

  Takashi Miyagawa; Shinsuke Inuki; Shinya Oishi; Hiroaki Ohno

  Organic letters, 19 Jul. 2019, Peer-reviewed

  Access this paper :

  
• Gold(I)-Catalyzed Cascade Cyclization Reactions of Allenynes for the Synthesis of Fused Cyclopropanes and Acenaphthenes

  Ikeuchi, T.; Inuki, S.; Oishi, S.; Ohno, H.

  Angewandte Chemie - International Edition, Jun. 2019, Peer-reviewed

  Access this paper :

  
• Scaffold hopping of fused piperidine-type NK3 receptor antagonists to reduce environmental impact

  Yamamoto, K.; Inuki, S.; Ohno, H.; Oishi, S.

  Bioorganic and Medicinal Chemistry, May 2019, Peer-reviewed

  Access this paper :

  
• Development of Mirror-Image Screening Systems for XIAP BIR3 Domain Inhibitors.

  Shu K; Iwamoto N; Honda K; Kondoh Y; Hirano H; Osada H; Ohno H; Fujii N; Oishi S

  Bioconjugate chemistry, Mar. 2019, Peer-reviewed

  
• Effect of cationic lipid in cationic liposomes on siRNA delivery into the lung by intravenous injection of cationic lipoplex.

  Yoshiyuki Hattori; Mari Nakamura; Nozomi Takeuchi; Kyoko Tamaki; Satono Shimizu; Yuki Yoshiike; Masamitsu Taguchi; Hiroaki Ohno; Kei-Ichi Ozaki; Hiraku Onishi

  Journal of drug targeting, Feb. 2019, Peer-reviewed

  
• Synthesis of Triazolo- and Oxadiazolopiperazines by Gold(I)-Catalyzed Domino Cyclization: Application to the Design of a Mitogen Activated Protein (MAP) Kinase Inhibitor

  Yamamoto, K.; Yoshikawa, Y.; Ohue, M.; Inuki, S.; Ohno, H.; Oishi, S.

  Organic Letters, 2019, Peer-reviewed

  
• Effect of cationic lipid type in cationic liposomes for siRNA delivery into the liver by sequential injection of chondroitin sulfate and cationic lipoplex

  Hattori, Y.; Takeuchi, N.; Nakamura, M.; Yoshiike, Y.; Taguchi, M.; Ohno, H.; Ozaki, K.-I.; Onishi, H.

  Journal of Drug Delivery Science and Technology, Sep. 2018, Peer-reviewed

  
• Gold(I)-Catalyzed Oxidative Cascade Cyclization of 1,4-Diyn-3-ones for the Construction of Tropone-Fused Furan Scaffolds

  Hamada, N.; Yamaguchi, A.; Inuki, S.; Oishi, S.; Ohno, H.

  Organic Letters, Aug. 2018, Peer-reviewed

  Access this paper :

  
• Use of a Compact Tripodal Tris(bipyridine) Ligand to Stabilize a Single-Metal-Centered Chirality: Stereoselective Coordination of Iron(II) and Ruthenium(II) on a Semirigid Hexapeptide Macrocycle

  Yuka Kobayashi; Masaru Hoshino; Tomoshi Kameda; Kazuya Kobayashi; Kenichi Akaji; Shinsuke Inuki; Hiroaki Ohno; Shinya Oishi

  Inorganic Chemistry, 07 May 2018, Peer-reviewed

  
• Head-to-tail macrocyclization of cysteine-free peptides using an o-aminoanilide linker

  Takumi Ohara; Masato Kaneda; Tomo Saito; Nobutaka Fujii; Hiroaki Ohno; Shinya Oishi

  Bioorganic and Medicinal Chemistry Letters, 01 May 2018, Peer-reviewed

  
• Structure-Activity Relationship Study of Cyclic Pentapeptide Ligands for Atypical Chemokine Receptor 3 (ACKR3)

  Haruka Sekiguchi; Tomoko Kuroyanagi; David Rhainds; Kazuya Kobayashi; Yuka Kobayashi; Hiroaki Ohno; Nikolaus Heveker; Kenichi Akaji; Nobutaka Fujii; Shinya Oishi

  Journal of Medicinal Chemistry, 26 Apr. 2018, Peer-reviewed

  
• Synthesis of jaspine B regioisomers through palladium-catalyzed stereoselective tetrahydrofuran formation: Insight into the ligand recognition of sphingosine kinases

  Takashi Miyagawa; Shinsuke Inuki; Maho Honda; Shinya Nakamura; Isao Nakanishi; Nobutaka Fujii; Shinya Oishi; Hiroaki Ohno

  Tetrahedron, 12 Apr. 2018, Peer-reviewed

  
• Synthesis of jaspine B regioisomers through palladium-catalyzed stereoselective tetrahydrofuran formation: Insight into the ligand recognition of sphingosine kinases

  Takashi Miyagawa; Shinsuke Inuki; Maho Honda; Shinya Nakamura; Isao Nakanishi; Nobutaka Fujii; Shinya Oishi; Hiroaki Ohno

  Tetrahedron, 12 Apr. 2018, Peer-reviewed

  
• Structure-Activity Relationship Study on Odoamide: Insights into the Bioactivities of Aurilide-Family Hybrid Peptide-Polyketides

  Masato Kaneda; Shinsaku Kawaguchi; Nobutaka Fujii; Hiroaki Ohno; Shinya Oishi

  ACS Medicinal Chemistry Letters, 12 Apr. 2018, Peer-reviewed

  
• Total Synthesis and Stereochemical Revision of Stereocalpin A: Mirror-Image Approach for Stereochemical Assignments of the Peptide-Polyketide Macrocycle

  Masato Kaneda; Shinsuke Inuki; Hiroaki Ohno; Shinya Oishi

  Journal of Organic Chemistry, 16 Mar. 2018, Peer-reviewed

  
• Structure-Activity Relationship Study of Odoamide: Insights into the Bioactivities of Aurilide-family Hybrid Peptide-Polyketides.

  Kaneda M; Kawaguchi S; Fujii N; Ohno H; Oishi S

  ACS Medicinal Chemistry Letters, Mar. 2018, Peer-reviewed

  
• Recent Progress in Palladium-Catalyzed Cascade Cyclizations for Natural Product Synthesis

  Hiroaki Ohno; Shinsuke Inuki

  Synthesis (Germany), 15 Feb. 2018, Peer-reviewed

  
• Introduction of a polar functional group to the lipid tail of 4-epi-jaspine B affects sphingosine kinase isoform selectivity

  Inuki, S.; Miyagawa, T.; Oishi, S.; Ohno, H.

  Chemical and Pharmaceutical Bulletin, 2018, Peer-reviewed

  
• Direct synthesis of aryl-annulated [c]carbazoles by gold(i)-catalysed cascade reaction of azide-diynes and arenes

  Yuiki Kawada; Shunsuke Ohmura; Misaki Kobayashi; Wataru Nojo; Masaki Kondo; Yuka Matsuda; Junpei Matsuoka; Shinsuke Inuki; Shinya Oishi; Chao Wang; Tatsuo Saito; Masanobu Uchiyama; Takanori Suzuki; Hiroaki Ohno

  Chemical Science, 2018, Peer-reviewed

  
• Fe(II)-Complexation of tripodal hexapeptide ligands with three bidentate triazolylpyridines: induction of metal-centred chirality by peptide macrocyclization

  Yuka Kobayashi; Tomoshi Kameda; Masaru Hoshino; Nobutaka Fujii; Hiroaki Ohno; Shinya Oishi

  DALTON TRANSACTIONS, Oct. 2017, Peer-reviewed

  
• Gold-Catalyzed Cascade Reaction of Skipped Diynes for the Construction of a Cyclohepta[b]pyrrole Scaffold

  Naoka Hamada; Yusuke Yoshida; Shinya Oishi; Hiroaki Ohno

  ORGANIC LETTERS, Jul. 2017, Peer-reviewed

  
• Investigation of the inhibitory mechanism of apomorphine against MDM2-p53 interaction

  Hiroyuki Ishiba; Taro Noguchi; Keitou Shu; Hiroaki Ohno; Kaori Honda; Yasumitsu Kondoh; Hiroyuki Osada; Nobutaka Fujii; Shinya Oishi

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jun. 2017, Peer-reviewed

  
• Identification of selective inhibitors of sphingosine kinases 1 and 2 through a structure-activity relationship study of 4-epi-jaspine B

  Hiroaki Ohno; Maho Honda; Naoka Hamada; Jun Miyagaki; Akira Iwata; Kazuhiro Otsuki; Toru Maruyama; Shinya Nakamura; Isao Nakanishi; Shinsuke Inuki; Nobutaka Fujii; Shinya Oishi

  BIOORGANIC & MEDICINAL CHEMISTRY, Jun. 2017, Peer-reviewed

  
• Total Synthesis of Dictyodendrins by the Gold-Catalyzed Cascade Cyclization of Conjugated Diynes with Pyrroles

  Junpei Matsuoka; Yuka Matsuda; Yuiki Kawada; Shinya Oishi; Hiroaki Ohno

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Jun. 2017, Peer-reviewed

  
• Evaluation of small interfering RNA delivery into cells by reverse transfection in suspension with cationic liposomes

  Y. Hattori; Y. Yoshiike; M. Honda; H. Ohno; H. Onishi

  Pharmacology & Pharmacy, May 2017, Peer-reviewed

  
• Synthesis of Grb2 SH2 Domain Proteins for Mirror-Image Screening Systems

  Taro Noguchi; Hiroyuki Ishiba; Kaori Honda; Yasumitsu Kondoh; Hiroyuki Osada; Hiroaki Ohno; Nobutaka Fujii; Shinya Oishi

  BIOCONJUGATE CHEMISTRY, Feb. 2017, Peer-reviewed

  
• Synthesis of the Src SH2 domain and its application in bioassays for mirror-image screening

  Keitou Shu; Taro Noguchi; Kaori Honda; Yasumitsu Kondoh; Hiroyuki Osada; Hiroaki Ohno; Nobutaka Fujii; Shinya Oishi

  RSC ADVANCES, 2017, Peer-reviewed

  
• Small interfering RNA delivery into the liver by cationic cholesterol derivative-based liposomes

  Yoshiyuki Hattori; Yoko Machida; Maho Honda; Nozomi Takeuchi; Yuki Yoshiike; Hiroaki Ohno; Hiraku Onishi

  JOURNAL OF LIPOSOME RESEARCH, 2017, Peer-reviewed

  
• Development of novel NK3 receptor antagonists with reduced environmental impact

  Koki Yamamoto; Shiho Okazaki; Hiroaki Ohno; Fuko Matsuda; Satoshi Ohkura; Kei-ichiro Maeda; Nobutaka Fujii; Shinya Oishi

  BIOORGANIC & MEDICINAL CHEMISTRY, Aug. 2016, Peer-reviewed

  
• Redox-induced Conformational Changes in 1,3-Propylene- and m-Xylylenebis[5-(10-butyl-5,10-dihydrobenzo[a]indolo[2,3-c]carbazole)]: Twin-BIC Donors that Form Sandwich-like Dimeric Cations Exhibiting NIR Absorption

  Takanori Suzuki; Wataru Nojo; Yuto Sakano; Ryo Katoono; Yusuke Ishigaki; Hiroaki Ohno; Kenshu Fujiwara

  CHEMISTRY LETTERS, Jul. 2016, Peer-reviewed

  
• Novel 3,4,7-Substituted Benzofuran Derivatives Having Binding Affinity to kappa-Opioid Receptor

  Daisuke Nishiyama; Yuki Sakai; Haruka Sekiguchi; Hiroaki Chiba; Ryosuke Misu; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  CHEMICAL & PHARMACEUTICAL BULLETIN, Jul. 2016, Peer-reviewed

  
• Total Synthesis of (+)-Conolidine by the Gold(I)-Catalyzed Cascade Cyclization of a Conjugated Enyne

  Saori Naoe; Yusuke Yoshida; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  JOURNAL OF ORGANIC CHEMISTRY, Jul. 2016, Peer-reviewed

  Access this paper :

  
• Formal Total Synthesis of (+/-)-Strictamine Based on a Gold-Catalyzed Cyclization

  Daisuke Nishiyama; Ayako Ohara; Hiroaki Chiba; Hiroshi Kumagai; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ORGANIC LETTERS, Apr. 2016, Peer-reviewed

  Access this paper :

  
• Structure-activity relationship study of 4-(thiazol-5-yl)benzoic acid derivatives as potent protein kinase CK2 inhibitors

  Hiroaki Ohno; Daiki Minamiguchi; Shinya Nakamura; Keito Shu; Shiho Okazaki; Maho Honda; Ryosuke Misu; Hirotomo Moriwaki; Shinsuke Nakanishi; Shinya Oishi; Takayoshi Kinoshita; Isao Nakanishi; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY, Mar. 2016, Peer-reviewed

  
• Total synthesis of odoamide, a novel cyclic depsipeptide, from an Okinawan marine cyanobacterium

  Masato Kaneda; Kosuke Sueyoshi; Toshiaki Teruya; Hiroaki Ohno; Nobutaka Fujii; Shinya Oishi

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2016, Peer-reviewed

  
• Gold-catalyzed three-component spirocyclization: a one-pot approach to functionalized pyrazolidines

  Bernd Wagner; Wolf Hiller; Hiroaki Ohno; Norbert Krause

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2016, Peer-reviewed

  
• Screening of a virtual mirror-image library of natural products

  Taro Noguchi; Shinya Oishi; Kaori Honda; Yasumitsu Kondoh; Tamio Saito; Hiroaki Ohno; Hiroyuki Osada; Nobutaka Fujii

  CHEMICAL COMMUNICATIONS, 2016, Peer-reviewed

  
• Synthesis of Fused Carbazoles by Gold-Catalyzed Tricyclization of Conjugated Diynes via Rearrangement of an N-Propargyl Group

  Masamitsu Taguchi; Yusuke Tokimizu; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ORGANIC LETTERS, Dec. 2015, Peer-reviewed

  Access this paper :

  
• Convenient synthesis of spiroindole derivatives via palladium-catalyzed cyclization of propargyl chlorides

  Akira Iwata; Shinsuke Inuki; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  TETRAHEDRON, Sep. 2015, Peer-reviewed

  Access this paper :

  
• The Effects of a Selective CK2 Inhibitor on Anti-glomerular Basement Membrane Glomerulonephritis in Rats

  Junfeng Shi; Ning Liu; Ying Xiao; Yoshinori Takei; Misato Yasue; Yamato Suzuki; Zengye Hou; Hiroaki Ohno; Masateru Yamada; Nobuhiro Fuchi; Keiyu Oshida; Yohei Miyamoto; Gozoh Tsujimoto; Akira Hirasawa

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Sep. 2015, Peer-reviewed

  
• Development of Novel CXC Chemokine Receptor 7 (CXCR7) Ligands: Selectivity Switch from CXCR4 Antagonists with a Cyclic Pentapeptide Scaffold

  Shinya Oishi; Tomoko Kuroyanagi; Tatsuhiko Kubo; Nicolas Montpas; Yasushi Yoshikawa; Ryosuke Misu; Yuka Kobayashi; Hiroaki Ohno; Nikolaus Heveker; Toshio Furuya; Nobutaka Fujii

  JOURNAL OF MEDICINAL CHEMISTRY, Jul. 2015, Peer-reviewed

  
• Gold-Catalyzed Cascade Cyclization of 2-Alkynyl-N-Propargylanilines by Rearrangement of a Propargyl Group

  Yusuke Tokimizu; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Jun. 2015, Peer-reviewed

  Access this paper :

  
• Identification of anti-HIV agents with a novel benzo[4,5]isothiazolo[2,3-a]pyrimidine scaffold

  Shiho Okazaki; Tsukasa Mizuhara; Kazuya Shimura; Hiroto Murayama; Hiroaki Ohno; Shinya Oishi; Masao Matsuoka; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY, Apr. 2015, Peer-reviewed

  Access this paper :

  
• Direct Construction of Fused Indoles by Gold-Catalyzed Cascade Cyclization of Conjugated Diynes

  Saori Naoe; Tatsuo Saito; Masanobu Uchiyama; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ORGANIC LETTERS, Apr. 2015, Peer-reviewed

  
• Dual Gold Catalysis: A Novel Synthesis of Bicyclic and Tricyclic Pyrroles from N-Propargyl Ynamides

  Yusuke Tokimizu; Marcel Wieteck; Matthias Rudolph; Shinya Oishi; Nobutaka Fujii; A. Stephen K. Hashmi; Hiroaki Ohno

  ORGANIC LETTERS, Feb. 2015, Peer-reviewed

  
• Formal [4+ 2] reaction between 1,3-diynes and pyrroles: Gold(I)-catalyzed indole synthesis by double hydroarylation

  Yuka Matsuda; Saori Naoe; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  Chemistry - A European Journal, 19 Jan. 2015, Peer-reviewed

  
• Structure-activity relationship study on senktide for development of novel potent neurokinin-3 receptor selective agonists

  Ryosuke Misu; Koki Yamamoto; Ai Yamada; Taro Noguchi; Hiroaki Ohno; Takashi Yamamura; Hiroaki Okamura; Fuko Matsuda; Satoshi Ohkura; Shinya Oishi; Nobutaka Fujii

  MEDCHEMCOMM, 2015, Peer-reviewed

  Access this paper :

  
• Formal [4+2] Reaction between 1,3-Diynes and Pyrroles: Gold(I)-Catalyzed Indole Synthesis by Double Hydroarylation

  Yuka Matsuda; Saori Naoe; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  CHEMISTRY-A EUROPEAN JOURNAL, Jan. 2015, Peer-reviewed

  
• Synthesis and biological evaluation of the [D-MeAla(11)]-epimer of coibamide A

  Ryota Nabika; Takashi L. Suyama; Andrew M. Hau; Ryosuke Misu; Hiroaki Ohno; Jane E. Ishmael; Kerry L. McPhail; Shinya Oishi; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jan. 2015, Peer-reviewed

  Access this paper :

  
• siRNA Delivery into Tumor Cells by Cationic Cholesterol Derivative-Based Nanoparticles and Liposomes

  Yoshiyuki Hattori; Eriko Hara; Yumiko Shingu; Daiki Minamiguchi; Ayako Nakamura; Shohei Arai; Hiroaki Ohno; Kumi Kawano; Nobutaka Fujii; Etsuo Yonemochi

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jan. 2015, Peer-reviewed

  
• Investigations of possible prodrug structures for 2-(2-mercaptophenyl) tetrahydropyrimidines: reductive conversion from anti-HIV agents with pyrimidobenzothiazine and isothiazolopyrimidine scaffolds

  Shiho Okazaki; Shinya Oishi; Tsukasa Mizuhara; Kazuya Shimura; Hiroto Murayama; Hiroaki Ohno; Masao Matsuoka; Nobutaka Fujii

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, Peer-reviewed

  
• Dual Gold Catalysis: Synthesis of Polycyclic Compounds via C-H Insertion of Gold Vinylidenes

  Marcel Wieteck; Yusuke Tokimizu; Matthias Rudolph; Frank Rominger; Hiroaki Ohno; Nobutaka Fujii; A. Stephen K. Hashmi

  CHEMISTRY-A EUROPEAN JOURNAL, Dec. 2014, Peer-reviewed

  
• Gold-Catalyzed Atom-Economical Cascade Reactions of Alkynes for Ring Formation

  Hiroaki Ohno; Shinya Oishi; Nobutaka Fujii

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Nov. 2014, Peer-reviewed

  
• Synthesis of IB-01212 by multiple N-methylations of peptide bonds

  Ryota Nabika; Shinya Oishi; Ryosuke Misu; Hiroaki Ohno; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY, Nov. 2014, Peer-reviewed

  Access this paper :

  
• Development of Novel Neurokinin 3 Receptor (NK3R) Selective Agonists with Resistance to Proteolytic Degradation

  Ryosuke Misu; Shinya Oishi; Ai Yamada; Takashi Yamamura; Fuko Matsuda; Koki Yamamoto; Taro Noguchi; Hiroaki Ohno; Hiroaki Okamura; Satoshi Ohkura; Nobutaka Fujii

  JOURNAL OF MEDICINAL CHEMISTRY, Oct. 2014, Peer-reviewed

  
• Synthesis and Applications of Vinylaziridines and Ethynylaziridines

  Hiroaki Ohno

  CHEMICAL REVIEWS, Aug. 2014, Peer-reviewed

  
• Design and synthesis of fluorescent probes for GPR54

  Masato Kaneda; Ryosuke Misu; Hiroaki Ohno; Akira Hirasawa; Nahoko Ieda; Yoshihisa Uenoyama; Hiroko Tsukamura; Kei-ichiro Maeda; Shinya Oishi; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY, Jul. 2014, Peer-reviewed

  Access this paper :

  
• Wurster's Blue-type Cation Radicals Framed in a 5,10-Dihydrobenzo[a]indolo[2,3-c]carbazole (BIC) Skeleton: Dual Electrochromism with Drastic Changes in UV/Vis/NIR and Fluorescence

  Takanori Suzuki; Yuto Sakano; Yusuke Tokimizu; Youhei Miura; Ryo Katoono; Kenshu Fujiwara; Naoki Yoshioka; Nobutaka Fujii; Hiroaki Ohno

  CHEMISTRY-AN ASIAN JOURNAL, Jul. 2014, Peer-reviewed

  
• Inside Back Cover: Wurster’s Blue-type Cation Radicals Framed in a 5,10-Dihydrobenzo[ a ]indolo[2,3- c ]carbazole (BIC) Skeleton: Dual Electrochromism with Drastic Changes in UV/Vis/NIR and Fluorescence (Chem. Asian J. 7/2014)

  Takanori Suzuki; Yuto Sakano; Yusuke Tokimizu; Youhei Miura; Ryo Katoono; Kenshu Fujiwara; Naoki Yoshioka; Nobutaka Fujii; Hiroaki Ohno

  Chem. Asian J., Jun. 2014, Peer-reviewed

  
• Optimization of diaryl amine derivatives as kinesin spindle protein inhibitors

  Tomoki Takeuchi; Shinya Oishi; Masato Kaneda; Ryosuke Misu; Hiroaki Ohno; Jun-ichi Sawada; Akira Asai; Shinya Nakamura; Isao Nakanishi; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY, Jun. 2014, Peer-reviewed

  Access this paper :

  
• Gold-Catalyzed Cascade Cyclization of (Azido)ynamides: An Efficient Strategy for the Construction of Indoloquinolines

  Yusuke Tokimizu; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ORGANIC LETTERS, Jun. 2014, Peer-reviewed

  
• Kinesin Spindle Protein Inhibitors with Diaryl Amine Scaffolds: Crystal Packing Analysis for Improved Aqueous Solubility

  Tomoki Takeuchi; Shinya Oishi; Masato Kaneda; Hiroaki Ohno; Shinya Nakamura; Isao Nakanishi; Masayoshi Yamane; Jun-ichi Sawada; Akira Asai; Nobutaka Fujii

  ACS MEDICINAL CHEMISTRY LETTERS, May 2014, Peer-reviewed

  
• Gold(I)-Catalyzed Regioselective Inter-/Intramolecular Addition Cascade of Di- and Triynes for Direct Construction of Substituted Naphthalenes (vol 77, pg 4907, 2012)

  Saori Naoe; Yamato Suzuki; Kimio Hirano; Yusuke Inaba; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  JOURNAL OF ORGANIC CHEMISTRY, Mar. 2014, Peer-reviewed

  
• Dual gold catalysis: Synthesis of polycyclic compounds via C-H insertion of gold vinylidenes

  Marcel Wieteck; Yusuke Tokimizu; Matthias Rudolph; Frank Rominger; Hiroaki Ohno; Nobutaka Fujii; A. Stephen K. Hashmi

  Chemistry - A European Journal, 12 Jan. 2014, Peer-reviewed

  
• The Synthesis of Alkaloids Using Transition-Metal-Catalyzed Intramolecular Amination Reactions

  Hiroaki Ohno; Hiroaki Chiba; Shinsuke Inuki; Shinya Oishi; Nobutaka Fujii

  SYNLETT, Jan. 2014, Peer-reviewed

  Access this paper :

  
• The Role of Acetylides in Dual Gold Catalysis: A Mechanistic Investigation of the Selectivity Difference in the Naphthalene Synthesis from Diynes

  Katharina Graf; Philip D. Hindenberg; Yusuke Tokimizu; Saori Naoe; Matthias Rudolph; Frank Rominger; Hiroaki Ohno; A. Stephen K. Hashmi

  CHEMCATCHEM, Jan. 2014, Peer-reviewed

  
• Synthesis of fused tetracyclic spiroindoles via palladium-catalysed cascade cyclisation

  Akira Iwata; Shinsuke Inuki; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  CHEMICAL COMMUNICATIONS, 2014, Peer-reviewed

  
• Gold-Catalyzed Cascade Reactions of Alkynes for Construction of Polycyclic Compounds

  Hiroaki Ohno

  ISRAEL JOURNAL OF CHEMISTRY, Nov. 2013, Peer-reviewed

  
• 5,10-Dihydrobenzo[a]indolo[2,3-c]carbazole: A Highly Fluorescent Disk-shaped Electron Donor Exhibiting Dual UV-vis-NIR and Fluorescence Spectral Changes upon Electrolysis

  Takanori Suzuki; Yusuke Toldmizu; Yuto Sakano; Ryo Katoono; Kenshu Fujiwara; Saori Naoe; Nobutaka Fujii; Hiroaki Ohno

  CHEMISTRY LETTERS, Sep. 2013, Peer-reviewed

  
• Structure-activity relationship study of phenylpyrazole derivatives as a novel class of anti-HIV agents

  Tsukasa Mizuhara; Takayuki Kato; Atsushi Hirai; Hideki Kurihara; Yaguhiro Shimada; Masahiko Taniguchi; Hideki Maeta; Hiroaki Togami; Kazuya Shimura; Masao Matsuoka; Shiho Okazaki; Tomoki Takeuchi; Hiroaki Ohno; Shinya Oishi; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Aug. 2013, Peer-reviewed

  
• Synthesis and functional analysis of deferriferrichrysin derivatives: Application to colorimetric pH indicators

  Yuka Kobayashi; Shinya Oishi; Kazuya Kobayashi; Hiroaki Ohno; Hiroko Tsutsumi; Yoji Hata; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY, Jul. 2013, Peer-reviewed

  Access this paper :

  
• Convergent Synthesis of (-)-Quinocarcin Based on the Combination of Sonogashira Coupling and Gold(I)-Catalyzed 6-endo-dig Hydroamination

  Hiroaki Chiba; Yuki Sakai; Ayako Ohara; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  CHEMISTRY-A EUROPEAN JOURNAL, Jul. 2013, Peer-reviewed

  
• Affinity-based screening of MDM2/MDMX-p53 interaction inhibitors by chemical array: Identification of novel peptidic inhibitors

  Taro Noguchi; Shinya Oishi; Kaori Honda; Yasumitsu Kondoh; Tamio Saito; Tatsuhiko Kubo; Masato Kaneda; Hiroaki Ohno; Hiroyuki Osada; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jul. 2013, Peer-reviewed

  Access this paper :

  
• Palladium-Catalyzed Medium-Ring Formation for Construction of the Core Structure of Laurencia Oxacycles: Synthetic Study of Laurendecumallene B

  Yuji Yoshimitsu; Shinsuke Inuki; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ORGANIC LETTERS, Jun. 2013, Peer-reviewed

  
• Synthesis of pachastrissamine (jaspine B) and its derivatives by the late-stage introduction of the C-2 alkyl side-chains using olefin cross metathesis

  Yuji Yoshimitsu; Jun Miyagaki; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  TETRAHEDRON, May 2013, Peer-reviewed

  
• Characterization of the receptor binding residues of kisspeptins by positional scanning using peptide photoaffinity probes

  Ryosuke Misu; Shinya Oishi; Shohei Setsuda; Taro Noguchi; Masato Kaneda; Hiroaki Ohno; Barry Evans; Jean-Marc Navenot; Stephen C. Peiper; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, May 2013, Peer-reviewed

  Access this paper :

  
• Enhanced Plasmid DNA Transfer into Tumor Cells by Nanoparticle Composed of Cholesteryl Triamine and Diamine

  Yoshiyuki Hattori; Tsukasa Nakamura; Hiroaki Ohno; Nobutaka Fujii; Yoshie Maitani

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, May 2013, Peer-reviewed

  
• Structure-activity relationship study of tachykinin peptides for the development of novel neurokinin-3 receptor selective agonists

  Ryosuke Misu; Taro Noguchi; Hiroaki Ohno; Shinya Oishi; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY, Apr. 2013, Peer-reviewed

  Access this paper :

  
• Design and synthesis of biotin- or alkyne-conjugated photoaffinity probes for studying the target molecules of PD 404182

  Tsukasa Mizuhara; Shinya Oishi; Hiroaki Ohno; Kazuya Shimura; Masao Matsuoka; Nobutaka Fujii

  Bioorganic and Medicinal Chemistry, 01 Apr. 2013, Peer-reviewed

  Access this paper :

  
• siRNA delivery into tumor cells by lipid- based nanoparticles composed of hydroxyethylated cholesteryl triamine

  Yoshiyuki Hattori; Tsukasa Nakamura; Hiroaki Ohno; Nobutaka Fujii; Yoshie Maitani

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Feb. 2013, Peer-reviewed

  
• Diversity-oriented synthesis of pyrazolo[4,3-b]indoles by gold-catalysed three-component annulation: application to the development of a new class of CK2 inhibitors

  Zengye Hou; Shinya Oishi; Yamato Suzuki; Tatsuhide Kure; Isao Nakanishi; Akira Hirasawa; Gozoh Tsujimoto; Hiroaki Ohno; Nobutaka Fujii

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2013, Peer-reviewed

  Access this paper :

  
• Kinesin spindle protein (KSP) inhibitors with carbazole and diaryl amine scaffolds

  Takeuchi Tomoki; Oishi Shinya; Kaneda Masato; Ohno Hiroaki; Sawada Jun-ichi; Asai Akira; Fujii Nobutaka

  Abstracts of Papers of the American Chemical Society, 2013, Peer-reviewed

  
• Lewis-acid-mediated ring-exchange reaction of dihydrobenzofurans and its application to the formal total synthesis of (-)-quinocarcinamide

  Hiroaki Chiba; Yuki Sakai; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  TETRAHEDRON LETTERS, Nov. 2012, Peer-reviewed

  Access this paper :

  
• Structure-activity relationship study of pyrimido[1,2-c][1,3]benzothiazin-6-imine derivatives for potent anti-HIV agents

  Tsukasa Mizuhara; Shinya Oishi; Hiroaki Ohno; Kazuya Shimura; Masao Matsuoka; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY, Nov. 2012, Peer-reviewed

  Access this paper :

  
• Gold(I)-Catalyzed Regioselective Inter-/Intramolecular Addition Cascade of Di- and Triynes for Direct Construction of Substituted Naphthalenes

  Saori Naoe; Yamato Suzuki; Kimio Hirano; Yusuke Inaba; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  JOURNAL OF ORGANIC CHEMISTRY, Jun. 2012, Peer-reviewed

  
• Paradoxical Downregulation of CXC Chemokine Receptor 4 Induced by Polyphemusin II-Derived Antagonists

  Ryo Masuda; Shinya Oishi; Noriko Tanahara; Hiroaki Ohno; Akira Hirasawa; Gozoh Tsujimoto; Yoshiaki Yano; Katsumi Matsuzaki; Jean-Marc Navenot; Stephen C. Peiper; Nobutaka Fujii

  BIOCONJUGATE CHEMISTRY, Jun. 2012, Peer-reviewed

  
• Development and application of fluorescent SDF-1 derivatives

  Ryo Masuda; Shinya Oishi; Noriko Tanahara; Hiroaki Ohno; Akira Hirasawa; Gozoh Tsujimoto; Eiichi Kodama; Masao Matsuoka; Nobutaka Fujii

  FUTURE MEDICINAL CHEMISTRY, May 2012, Peer-reviewed

  Access this paper :

  
• Development and application of fluorescent SDF-1 derivatives

  Ryo Masuda; Shinya Oishi; Noriko Tanahara; Hiroaki Ohno; Akira Hirasawa; Gozoh Tsujimoto; Eiichi Kodama; Masao Matsuoka; Nobutaka Fujii

  FUTURE MEDICINAL CHEMISTRY, May 2012, Peer-reviewed

  Access this paper :

  
• Synthesis and application of an N-delta-acetyl-N-delta-hydroxyornithine analog: Identification of novel metal complexes of deferriferrichrysin

  Kazuya Kobayashi; Shinya Oishi; Yuka Kobayashi; Hiroaki Ohno; Hiroko Tsutsumi; Yoji Hata; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY, Apr. 2012, Peer-reviewed

  Access this paper :

  
• Double C-H Functionalization in Sequential Order: Direct Synthesis of Polycyclic Compounds by a Palladium-Catalyzed C-H Alkenylation-Arylation Cascade

  Hiroaki Ohno; Mutsumi Iuchi; Naoto Kojima; Takehiko Yoshimitsu; Nobutaka Fujii; Tetsuaki Tanaka

  CHEMISTRY-A EUROPEAN JOURNAL, Apr. 2012, Peer-reviewed

  
• Structure-Based Design Of Novel Potent Protein Kinase CK2 (CK2) Inhibitors with Phenyl-azole Scaffolds

  Zengye Hou; Isao Nakanishi; Takayoshi Kinoshita; Yoshinori Takei; Misato Yasue; Ryosuke Misu; Yamato Suzuki; Shinya Nakamura; Tatsuhide Kure; Hiroaki Ohno; Katsumi Murata; Kazuo Kitaura; Akira Hirasawa; Gozoh Tsujimoto; Shinya Oishi; Nobutaka Fujii

  JOURNAL OF MEDICINAL CHEMISTRY, Mar. 2012, Peer-reviewed

  
• Structure-Activity Relationship Study of a CXC Chemokine Receptor Type 4 Antagonist, FC131, Using a Series of Alkene Dipeptide Isosteres

  Kazuya Kobayashi; Shinya Oishi; Ryoko Hayashi; Kenji Tomita; Tatsuhiko Kubo; Noriko Tanahara; Hiroaki Ohno; Yasushi Yoshikawa; Toshio Furuya; Masaru Hoshino; Nobutaka Fujii

  JOURNAL OF MEDICINAL CHEMISTRY, Mar. 2012, Peer-reviewed

  
• Efficient synthesis of aminomethylated azaindoles and corresponding pyrrole-fused derivatives by copper-catalyzed domino multicomponent coupling and cyclization

  Zengye Hou; Yamato Suzuki; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  TETRAHEDRON, Feb. 2012, Peer-reviewed

  Access this paper :

  
• Gold-Catalyzed Three-Component Annulation: Efficient Synthesis of Highly Functionalized Dihydropyrazoles from Alkynes, Hydrazines, and Aldehydes or Ketones

  Yamato Suzuki; Saori Naoe; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ORGANIC LETTERS, Jan. 2012, Peer-reviewed

  
• Concise synthesis and anti-HIV activity of pyrimido[1,2-c][1,3]benzothiazin-6-imines and related tricyclic heterocycles

  Tsukasa Mizuhara; Shinya Oishi; Hiroaki Ohno; Kazuya Shimura; Masao Matsuoka; Nobutaka Fujii

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, Peer-reviewed

  Access this paper :

  
• Design and synthesis of a novel class of CK2 inhibitors: application of copper- and gold-catalysed cascade reactions for fused nitrogen heterocycles

  Yamato Suzuki; Shinya Oishi; Yoshinori Takei; Misato Yasue; Ryosuke Misu; Saori Naoe; Zengye Hou; Tatsuhide Kure; Isao Nakanishi; Hiroaki Ohno; Akira Hirasawa; Gozoh Tsujimoto; Nobutaka Fujii

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, Peer-reviewed

  Access this paper :

  
• Total Synthesis of (-)-Quinocarcin by Gold(I)-Catalyzed Regioselective Hydroamination

  Hiroaki Chiba; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, Peer-reviewed

  
• Gold-Catalyzed Three-Component Annulation: Efficient Synthesis of Highly Functionalized Dihydropyrazoles from Alkynes, Hydrazines, and Aldehydes or Ketones

  Yamato Suzuki; Saori Naoe; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ORGANIC LETTERS, Jan. 2012, Peer-reviewed

  
• Gold(I)-Catalyzed Polycyclizations of Polyenyne-Type Anilines Based on Hydroamination and Consecutive Hydroarylation Cascade

  Kimio Hirano; Yusuke Inaba; Kiyosei Takasu; Shinya Oishi; Yoshiji Takemoto; Nobutaka Fujii; Hiroaki Ohno

  JOURNAL OF ORGANIC CHEMISTRY, Nov. 2011, Peer-reviewed

  
• A detailed thermodynamic profile of cyclopentyl and isopropyl derivatives binding to CK2 kinase

  Takayoshi Kinoshita; Yusuke Sekiguchi; Harumi Fukada; Tetsuko Nakaniwa; Toshiji Tada; Shinya Nakamura; Kazuo Kitaura; Hiroaki Ohno; Yamato Suzuki; Akira Hirasawa; Isao Nakanishi; Gozoh Tsujimoto

  MOLECULAR AND CELLULAR BIOCHEMISTRY, Oct. 2011, Peer-reviewed

  
• Pachastrissamine (jaspine B) and its stereoisomers inhibit sphingosine kinases and atypical protein kinase C

  Yuji Yoshimitsu; Shinya Oishi; Jun Miyagaki; Shinsuke Inuki; Hiroaki Ohno; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY, Sep. 2011, Peer-reviewed

  Access this paper :

  
• Palladium-Catalyzed Construction of Polycyclic Heterocycles by an Alkyne Insertion and Direct Arylation Cascade

  Hiroaki Ohno; Mio Yamamoto; Mutsumi Iuchi; Nobutaka Fujii; Tetsuaki Tanaka

  SYNTHESIS-STUTTGART, Aug. 2011, Peer-reviewed

  Access this paper :

  
• Direct synthesis of highly fused perimidines by copper(I)-catalyzed hydroamination of 2-ethynylbenzaldehydes

  Yusuke Tokimizu; Yusuke Ohta; Hiroaki Chiba; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  TETRAHEDRON, Jul. 2011, Peer-reviewed

  Access this paper :

  
• Structure-Activity Relationships of Carboline and Carbazole Derivatives as a Novel Class of ATP-Competitive Kinesin Spindle Protein Inhibitors

  Tomoki Takeuchi; Shinya Oishi; Toshiaki Watanabe; Hiroaki Ohno; Jun-ichi Sawada; Kenji Matsuno; Akira Asai; Naoya Asada; Kazuo Kitaura; Nobutaka Fujii

  JOURNAL OF MEDICINAL CHEMISTRY, Jul. 2011, Peer-reviewed

  
• Formal Total Synthesis of (+)-Lysergic Acid via Zinc(II)-Mediated Regioselective Ring-Opening Reduction of 2-Alkynyl-3-indolyloxirane

  Akira Iwata; Shinsuke Inuki; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  JOURNAL OF ORGANIC CHEMISTRY, Jul. 2011, Peer-reviewed

  
• Potent CXCR4 Antagonists Containing Amidine Type Peptide Bond Isosteres

  Eriko Inokuchi; Shinya Oishi; Tatsuhiko Kubo; Hiroaki Ohno; Kazuya Shimura; Masao Matsuoka; Nobutaka Fujii

  ACS MEDICINAL CHEMISTRY LETTERS, Jun. 2011, Peer-reviewed

  
• Concise site-specific synthesis of DTPA-peptide conjugates: Application to imaging probes for the chemokine receptor CXCR4

  Ryo Masuda; Shinya Oishi; Hiroaki Ohno; Hiroyuki Kimura; Hideo Saji; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY, May 2011, Peer-reviewed

  Access this paper :

  
• Enantioselective Total Synthesis of (+)-Lysergic Acid, (+)-Lysergol, and (+)-Isolysergol by Palladium-Catalyzed Domino Cyclization of Allenes Bearing Amino and Bromoindolyl Groups

  Shinsuke Inuki; Akira Iwata; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  JOURNAL OF ORGANIC CHEMISTRY, Apr. 2011, Peer-reviewed

  
• Total Synthesis of (+/-)-Lysergic Acid, Lysergol, and Isolysergol by Palladium-Catalyzed Domino Cyclization of Amino Allenes Bearing a Bromoindolyl Group (vol 10, pg 5239, 2008)

  Shinsuke Inuki; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ORGANIC LETTERS, Apr. 2011, Peer-reviewed

  
• A novel samarium(II)-mediated tandem spirocyclization onto an aromatic ring

  Hiroki Iwasaki; Nozomi Tsutsui; Toru Eguchi; Hiroaki Ohno; Masayuki Yamashita; Tetsuaki Tanaka

  TETRAHEDRON LETTERS, Apr. 2011, Peer-reviewed

  
• Direct Synthesis of Fused Indoles by Gold-Catalyzed Cascade Cyclization of Diynes

  Kimio Hirano; Yusuke Inaba; Naoya Takahashi; Masanao Shimano; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  JOURNAL OF ORGANIC CHEMISTRY, Mar. 2011, Peer-reviewed

  
• Activation of Neuropeptide FF Receptors by Kisspeptin Receptor Ligands

  Shinya Oishi; Ryosuke Misu; Kenji Tomita; Shohei Setsuda; Ryo Masuda; Hiroaki Ohno; Yousuke Naniwa; Nahoko Ieda; Naoko Inoue; Satoshi Ohkura; Yoshihisa Uenoyama; Hiroko Tsukamura; Kei-ichiro Maeda; Akira Hirasawa; Gozoh Tsujimoto; Nobutaka Fujii

  ACS MEDICINAL CHEMISTRY LETTERS, Jan. 2011, Peer-reviewed

  
• Design and synthesis of amidine-type peptide bond isosteres: application of nitrile oxide derivatives as active ester equivalents in peptide and peptidomimetics synthesis

  Eriko Inokuchi; Ai Yamada; Kentaro Hozumi; Kenji Tomita; Shinya Oishi; Hiroaki Ohno; Motoyoshi Nomizu; Nobutaka Fujii

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, Peer-reviewed

  Access this paper :

  
• Structure-activity Relationship Study on a CXCR4 Antagonist FC131 Using Alkene-type Dipeptide Isosteres

  Kazuya Kobayashi; Shinya Oishi; Ryoko Hayashi; Kenji Tomita; Tatsuhiko Kubo; Noriko Tanahara; Hiroaki Ohno; Takeshi Naito; Masao Matsuoka; Nobutaka Fujii

  BIOPOLYMERS, 2011, Peer-reviewed

  
• Affinity selection and sequence-activity relationships of HIV-1 membrane fusion inhibitors directed at the drug-resistant variants

  Shinya Oishi; Kentaro Watanabe; Saori Ito; Michinori Tanaka; Hiroki Nishikawa; Hiroaki Ohno; Kazuki Shimane; Kazuki Izumi; Yasuko Sakagami; Eiichi N. Kodama; Masao Matsuoka; Akira Asai; Nobutaka Fujii

  MEDCHEMCOMM, Oct. 2010, Peer-reviewed

  Access this paper :

  
• Direct Synthesis of Quinazolines through Copper-Catalyzed Reaction of Aniline-Derived Benzamidines

  Yusuke Ohta; Yusuke Tokimizu; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ORGANIC LETTERS, Sep. 2010, Peer-reviewed

  
• Kinesin Spindle Protein (KSP) Inhibitors with 2,3-Fused Indole Scaffolds

  Shinya Oishi; Toshiaki Watanabe; Jun-ichi Sawada; Akira Asai; Hiroaki Ohno; Nobutaka Fujii

  JOURNAL OF MEDICINAL CHEMISTRY, Jul. 2010, Peer-reviewed

  
• Stereoselective Divergent Synthesis of Four Diastereomers of Pachastrissamine (Jaspine B)

  Yuji Yoshimitsu; Shinsuke Inuki; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  JOURNAL OF ORGANIC CHEMISTRY, Jun. 2010, Peer-reviewed

  
• Ring-Construction/Stereoselective Functionalization Cascade: Total Synthesis of Pachastrissamine (Jaspine B) through Palladium-Catalyzed Bis-cyclization of Propargyl Chlorides and Carbonates

  Shinsuke Inuki; Yuji Yoshimitsu; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  JOURNAL OF ORGANIC CHEMISTRY, Jun. 2010, Peer-reviewed

  
• Construction of Linked Nitrogen Heterocycles by Palladium(0)-Catalyzed Intramolecular Domino Cyclization of 2-Alkynylaziridines Bearing a 2-Aminoethyl Group via Ring Expansion with Isocyanate

  Akinori Okano; Shinya Oishi; Tetsuaki Tanaka; Nobutaka Fujii; Hiroaki Ohno

  JOURNAL OF ORGANIC CHEMISTRY, May 2010, Peer-reviewed

  
• Gold-Catalyzed Intramolecular Alkyne Cycloisomerization Cascade: Direct Synthesis of Aryl-Annulated[a]carbazoles from Aniline-Substituted Diethynylarenes

  Kimio Hirano; Yusuke Inaba; Toshiaki Watanabe; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ADVANCED SYNTHESIS & CATALYSIS, Feb. 2010, Peer-reviewed

  
• Efficient Synthesis of Pyrimido[1,2-c] [1,3]benzothiazin-6-imines and Related Tricyclic Heterocycles by SNAr-Type C-S, C-N, or C-O Bond Formation with Heterocumulenes

  Tsukasa Mizuhara; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  JOURNAL OF ORGANIC CHEMISTRY, Jan. 2010, Peer-reviewed

  
• Synthesis and biological evaluation of selective CXCR4 antagonists containing alkene dipeptide isosteres

  Tetsuo Narumi; Ryoko Hayashi; Kenji Tomita; Kazuya Kobayashi; Noriko Tanahara; Hiroaki Ohno; Takeshi Naito; Eiichi Kodama; Masao Matsuoka; Shinya Oishi; Nobutaka Fujii

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2010, Peer-reviewed

  
• Synthesis of Fused and Linked Bicyclic Nitrogen Heterocycles by Palladium-Catalyzed Domino Cyclization of Propargyl Bromides

  Akinori Okano; Koji Tsukamoto; Shohei Kosaka; Hatsuo Maeda; Shinya Oishi; Tetsuaki Tanaka; Nobutaka Fujii; Hiroaki Ohno

  CHEMISTRY-A EUROPEAN JOURNAL, 2010, Peer-reviewed

  
• Bioorganic synthesis of a recombinant HIV-1 fusion inhibitor, SC35EK, with an N-terminal pyroglutamate capping group

  Kazumi Kajiwara; Kentaro Watanabe; Rei Tokiwa; Tomoko Kurose; Hiroaki Ohno; Hiroko Tsutsumi; Yoji Hata; Kazuki Izumi; Eiichi Kodama; Masao Matsuoka; Shinya Oishi; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY, Dec. 2009, Peer-reviewed

  Access this paper :

  
• Bioorganic synthesis of end-capped anti-HIV peptides by simultaneous cyanocysteine-mediated cleavages of recombinant proteins

  Michinori Tanaka; Kazumi Kajiwara; Rei Tokiwa; Kentaro Watanabe; Hiroaki Ohno; Hiroko Tsutsumi; Yoji Hata; Kazuki Izumi; Eiichi Kodama; Masao Matsuoka; Shinya Oishi; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY, Nov. 2009, Peer-reviewed

  
• Ring-Construction/Stereoselective Functionalization Cascade: Total Synthesis of Pachastrissamine (Jaspine B) through Palladium-Catalyzed Bis-cyclization of Bromoallenes

  Shinsuke Inuki; Yuji Yoshimitsu; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ORGANIC LETTERS, Oct. 2009, Peer-reviewed

  
• X-ray Crystallographic Study of an HIV-1 Fusion Inhibitor with the gp41 S138A Substitution

  Tsuyoshi Watabe; Yukihiro Terakawa; Kentaro Watanabe; Hiroaki Ohno; Hiroaki Nakano; Toru Nakatsu; Hiroaki Kato; Kazuki Izumi; Eiichi Kodama; Masao Matsuoka; Kazuo Kitaura; Shinya Oishi; Nobutaka Fujii

  JOURNAL OF MOLECULAR BIOLOGY, Sep. 2009, Peer-reviewed

  
• Construction of Nitrogen Heterocycles Bearing an Aminomethyl Group by Copper-Catalyzed Domino Three-Component Coupling-Cyclization

  Yusuke Ohta; Hiroaki Chiba; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  JOURNAL OF ORGANIC CHEMISTRY, Sep. 2009, Peer-reviewed

  
• Rapid Access to 3-(Aminomethyl)isoquinoline-Fused Polycyclic Compounds by Copper-Catalyzed Four-Component Coupling, Cascade Cyclization, and Oxidation

  Yusuke Ohta; Yushi Kubota; Tsuyoshi Watabe; Hiroaki Chiba; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  JOURNAL OF ORGANIC CHEMISTRY, Aug. 2009, Peer-reviewed

  
• Design and synthesis of membrane fusion inhibitors against the feline immunodeficiency virus

  Shinya Oishi; Yasuyo Kodera; Hiroki Nishikawa; Hirotaka Kamitani; Tsuyoshi Watabe; Hiroaki Ohno; Tadafumi Tochikura; Kazuki Shimane; Eiichi Kodama; Masao Matsuoka; Fuminori Mizukoshi; Hajime Tsujimoto; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY, Jul. 2009, Peer-reviewed

  
• Palladium-Catalyzed Direct Synthesis of Carbazoles via One-Pot N-Arylation and Oxidative Biaryl Coupling: Synthesis and Mechanistic Study

  Toshiaki Watanabe; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  JOURNAL OF ORGANIC CHEMISTRY, Jul. 2009, Peer-reviewed

  
• Amino Acid-Based Synthesis of Trifluoromethylalkene Dipeptide Isosteres by Alcohol-Assisted Nucleophilic Trifluoromethylation and Organozinc-Copper-Mediated S(N)2 ' Alkylation

  Kazuya Kobayashi; Tetsuo Narumi; Shinya Oishi; Hiroaki Ohno; Nobutaka Fujii

  JOURNAL OF ORGANIC CHEMISTRY, Jun. 2009, Peer-reviewed

  
• Efficient Synthesis of Aminomethylated Pyrroloindoles and Dipyrrolopyridines via Controlled Copper-Catalyzed Domino Multicomponent Coupling and Bis-cyclization

  Yamato Suzuki; Yusuke Ohta; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  JOURNAL OF ORGANIC CHEMISTRY, Jun. 2009, Peer-reviewed

  
• Facile Synthesis of 1 2,3,4-Tetrahydro-beta-carbolines by One-Pot Domino Three-Component Indole Formation and Nucleophilic Cyclization

  Yusuke Ohta; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ORGANIC LETTERS, May 2009, Peer-reviewed

  
• Structure-activity relationship study on polyglutamine binding peptide QBP1

  Kenji Tomita; H. Akiko Popiel; Yoshitaka Nagai; Tatsushi Toda; Yuji Yoshimitsu; Hiroaki Ohno; Shinya Oishi; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY, Feb. 2009, Peer-reviewed

  
• Structure of human protein kinase CK2 alpha 2 with a potent indazole-derivative inhibitor

  Tetsuko Nakaniwa; Takayoshi Kinoshita; Yusuke Sekiguchi; Toshiji Tada; Isao Nakanishi; Kazuo Kitaura; Yamato Suzuki; Hiroaki Ohno; Akira Hirasawa; Gozoh Tsujimoto

  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Feb. 2009, Peer-reviewed

  
• Peptide bond mimicry by (E)-alkene and (Z)-fluoroalkene peptide isosteres: synthesis and bioevaluation of alpha-helical anti-HIV peptide analogues

  Shinya Oishi; Hirotaka Kamitani; Yasuyo Kodera; Kentaro Watanabe; Kazuya Kobayashi; Tetsuo Narumi; Kenji Tomita; Hiroaki Ohno; Takeshi Naito; Eiichi Kodama; Masao Matsuoka; Nobutaka Fujii

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2009, Peer-reviewed

  
• Synthesis and Application of (Z)-Alkene- and (E)-Fluoroalkene-Dipeptide Isosteres as cis-Amide Equivalents

  Kenji Tomita; Tetsuo Narumi; Ayumu Niida; Shinya Oishi; Hiroaki Ohno; Nobutaka Fujii

  PEPTIDES FOR YOUTH, 2009, Peer-reviewed

  
• Development of a Novel Fusion Inhibitor against T-20-resistant HIV-1

  Shinya Oishi; Saori Ito; Hiroki Nishikawa; Michinori Tanaka; Hiroaki Ohno; Akira Otaka; Kazuki Izumi; Eiichi Kodama; Masao Matsuoka; Nobutaka Fujii

  PEPTIDES FOR YOUTH, 2009, Peer-reviewed

  
• Cu(II)-mediated oxidative intermolecular ortho C-H functionalisation using tetrahydropyrimidine as the directing group

  Tsukasa Mizuhara; Shinsuke Inuki; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  CHEMICAL COMMUNICATIONS, 2009, Peer-reviewed

  
• Development of Novel G-Protein-Coupled Receptor 54 Agonists with Resistance to Degradation by Matrix Metalloproteinase

  Kenji Tomita; Shinya Oishi; Hiroaki Ohno; Stephen C. Peiper; Nobutaka Fujii

  JOURNAL OF MEDICINAL CHEMISTRY, Dec. 2008, Peer-reviewed

  
• Total Synthesis of (+/-)-Lysergic Acid, Lysergol, and Isolysergol by Palladium-Catalyzed Domino Cyclization of Amino Allenes Bearing a Bromoindolyl Group

  Shinsuke Inuki; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ORGANIC LETTERS, Nov. 2008, Peer-reviewed

  
• Identification of minimal sequence for HIV-1 fusion inhibitors

  Hiroki Nishikawa; Shinya Oishi; Mizuno Fujita; Kentaro Watanabe; Rei Tokiwa; Hiroaki Ohno; Eiichi Kodama; Kazuki Izumi; Keiko Kajiwara; Takeshi Naitoh; Masao Matsuoka; Akira Otaka; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY, Oct. 2008, Peer-reviewed

  Access this paper :

  
• Structure-activity relationships of pyrazine-based CK2 inhibitors: Synthesis and evaluation of 2,6-disubstituted pyrazines and 4,6-disubstituted pyrimidines

  Yarnato Suzuki; Jerome Cluzeau; Takafumi Hara; Akira Hirasawa; Gozoh Tsujimoto; Shinya Oishi; Hiroaki Ohno; Nobutaka Fujii

  ARCHIV DER PHARMAZIE, Sep. 2008, Peer-reviewed

  
• Synthesis of highly functionalized alkene dipeptide isosteres and its application to the structure - Activity relationship study on bioactive peptides

  Shinya Oishi; Tetsuo Narumi; Hiroaki Ohno; Akira Otaka; Nobutaka Fujii

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Sep. 2008, Peer-reviewed

  
• Samarium(II)-mediated spirocyclization by intramolecular aryl radical addition onto an aromatic ring

  Hiroki Iwasaki; Toru Eguchi; Nozomi Tsutsui; Hiroaki Ohno; Tetsuaki Tanaka

  JOURNAL OF ORGANIC CHEMISTRY, Sep. 2008, Peer-reviewed

  
• Concise synthesis of indole-fused 1,4-diazepines through copper(I)-catalyzed domino three-component coupling-cyclization-N-arylation under microwave irradiation

  Yusuke Ohta; Hiroaki Chiba; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ORGANIC LETTERS, Aug. 2008, Peer-reviewed

  
• Identification of novel non-peptide CXCR4 antagonists by ligand-based design approach

  Satoshi Ueda; Manabu Kato; Shinsuke Inuki; Hiroaki Ohno; Barry Evans; Zi-xuan Wang; Stephen C. Peiper; Kazuki Izumi; Eiichi Kodama; Masao Matsuoka; Hideko Nagasawa; Shinya Oishi; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jul. 2008, Peer-reviewed

  
• Efficient synthesis of trifluoromethyl and related trisubstituted alkene dipeptide isosteres by palladium-catalyzed carbonylation of amino acid derived allylic carbonates

  Eriko Inokuchi; Tetsuo Narumi; Ayumu Niida; Kazuya Kobayashi; Kenji Tomita; Shinya Oishi; Hiroaki Ohno; Nobutaka Fujii

  JOURNAL OF ORGANIC CHEMISTRY, May 2008, Peer-reviewed

  
• Diastereoselective synthesis of highly functionalized fluoroalkene dipeptide isosteres and its application to Fmoc-based solid-phase synthesis of a cyclic pentapeptide mimetic

  Tetsuo Narumi; Kenji Tomita; Eriko Inokuchi; Kazuya Kobayashi; Shinya Oishi; Hiroaki Ohno; Nobutaka Fujii

  TETRAHEDRON, May 2008, Peer-reviewed

  
• Palladium-catalyzed sp(3) C-H activation of simple alkyl groups: Direct preparation of indoline derivatives from N-alkyl-2-bromoanilines

  Toshiaki Watanabe; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ORGANIC LETTERS, May 2008, Peer-reviewed

  
• Synthesis and application of fluorescein- and biotin-labeled molecular probes for the chemokine receptor CXCR4

  Shinya Oishi; Ryo Masuda; Barry Evans; Satoshi Ueda; Yukiko Goto; Hiroaki Ohno; Akira Hirasawa; Gozoh Tsujimoto; Zixuan Wang; Stephen C. Peiper; Takeshi Naito; Eiichi Kodama; Masao Matsuoka; Nobutaka Fujii

  CHEMBIOCHEM, May 2008, Peer-reviewed

  
• Direct construction of bicyclic heterocycles by palladium-catalyzed domino cyclization of propargyl bromides

  Hiroaki Ohno; Akinori Okano; Shohei Kosaka; Koji Tsukamoto; Miyo Ohata; Kotaro Ishihara; Hatsuo Maeda; Tetsuaki Tanaka; Nobutaka Fujii

  ORGANIC LETTERS, Mar. 2008, Peer-reviewed

  
• Design of a novel HIV-1 fusion inhibitor that displays a minimal interface for binding affinity

  Shinya Oishi; Saori Ito; Hiroki Nishikawa; Kentaro Watanabe; Michinori Tanaka; Hiroaki Ohno; Kazuki Izumi; Yasuko Sakagami; Eiichi Kodama; Masao Matsuoka; Nobutaka Fujii

  JOURNAL OF MEDICINAL CHEMISTRY, Feb. 2008, Peer-reviewed

  
• Structure-activity relationship study and NMR analysis of fluorobenzoyl pentapeptide GPR54 agonists

  Kenji Tomita; Shinya Oishi; Hiroaki Ohno; Nobutaka Fujii

  BIOPOLYMERS, 2008, Peer-reviewed

  
• Palladium-catalysed biscyclisation of allenic bromoalkenes through a zipper-mode cascade

  Akinori Okano; Tsuyoshi Mizutani; Shinya Oishi; Tetsuaki Tanaka; Hiroaki Ohno; Nobutaka Fujii

  CHEMICAL COMMUNICATIONS, 2008, Peer-reviewed

  
• Facile synthesis of 3-(aminomethyl)isoquinolines by copper-catalysed domino four-component coupling and cyclisation

  Yusuke Ohta; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  CHEMICAL COMMUNICATIONS, 2008, Peer-reviewed

  
• Gold-catalyzed hydroarylation of allenes: A highly regioselective carbon-carbon bond formation producing six-membered rings

  Toshiaki Watanabe; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ORGANIC LETTERS, Nov. 2007, Peer-reviewed

  
• Zipper-mode double C-H activation: Palladium-catalyzed direct construction of highly-fused heterocyclic systems

  Hiroaki Ohno; Mutsumi Iuchi; Nobutaka Fujii; Tetsuaki Tanaka

  ORGANIC LETTERS, Nov. 2007, Peer-reviewed

  
• Facile synthesis of fluoroalkenes by palladium-catalyzed reductive defluorination of allylic gem-difluorides

  Tetsuo Narumi; Kenji Tomita; Eriko Inokuchi; Kazuya Kobayashi; Shinya Oishi; Hiroaki Ohno; Nobutaka Fujii

  ORGANIC LETTERS, Aug. 2007, Peer-reviewed

  
• SAR and QSAR studies on the n-terminally acylated pentapeptide agonists for GPR54

  Kenji Tomita; Shinya Oishi; Jerome Cluzeau; Hiroaki Ohno; Jean-Marc Navenot; Zi-xuan Wang; Stephen C. Peiper; Miki Akamatsu; Nobutaka Fujii

  JOURNAL OF MEDICINAL CHEMISTRY, Jul. 2007, Peer-reviewed

  
• A highly regio- and stereoselective formation of bicyclo[4.2.0]oct-5-ene derivatives through thermal intramolecular [2+2] cycloaddition of allenes

  Hiroaki Ohno; Tsuyoshi Mizutani; Yoichi Kadoh; Akimasa Aso; Kumiko Miyamura; Nobutaka Fujii; Tetsuaki Tanaka

  JOURNAL OF ORGANIC CHEMISTRY, Jun. 2007, Peer-reviewed

  
• A novel oxazolidine linker for the synthesis of peptide aldehydes

  Michinori Tanaka; Shinya Oishi; Hiroaki Ohno; Nobutaka Fujii

  INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS, Jun. 2007, Peer-reviewed

  
• Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: Disclosing the importance of side-chain and backbone functionalities

  Satoshi Ueda; Shinya Oishi; Zi-xuan Wang; Takanobu Araki; Hirokazu Tamamura; Jerome Cluzeau; Hiroaki Ohno; Shuichi Kusano; Hideki Nakashima; John O. Trent; Stephen C. Peiper; Nobutaka Fujii

  JOURNAL OF MEDICINAL CHEMISTRY, Jan. 2007, Peer-reviewed

  
• Design and synthesis of all diastereomers of cyclic pseudo-dipeptides as mimics of cyclic CXCR4 pentapeptide antagonists

  Jerome Cluzeau; Shinya Oishi; Hiroaki Ohno; Zixuan Wang; Barry Evans; Stephen C. Peiper; Nobutaka Fujii

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2007, Peer-reviewed

  
• Fmoc-based solid-phase synthesis of GPR54-agonistic pentapeptide derivatives containing alkene- and fluoroalkene-dipeptide isosteres

  Kenji Tomita; Tetsuo Narumi; Ayumu Niida; Shinya Oishi; Hiroaki Ohno; Nobutaka Fujii

  BIOPOLYMERS, 2007, Peer-reviewed

  
• Erratum: Direct synthesis of 2-(aminomethyl)-indoles through copper(I)-catalyzed domino three-component coupling and cyclization reactions (Angewandte Chemie - International Edition (2007) 46, (2295-2298) DOI: 10.1002/anie.200604342)

  Ohno, H.; Ohta, Y.; Oishi, S.; Fujii, N.

  Angewandte Chemie - International Edition, 2007, Peer-reviewed

  
• One-pot synthesis of carbazoles by palladium-catalyzed N-arylation and oxidative coupling

  Toshiaki Watanabe; Satoshi Ueda; Shinsuke Inuki; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  CHEMICAL COMMUNICATIONS, 2007, Peer-reviewed

  
• Heck-type cyclization of oxime ethers: Stereoselective carbon-carbon bond formation with aryl halides to produce heterocyclic oximes

  Hiroaki Ohno; Akimasa Aso; Yoichi Kadoh; Nobutaka Fujii; Tetsuaki Tanaka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, Peer-reviewed

  
• Direct synthesis of 2-(aminomethyl)indoles through copper(I)-catalyzed domino three-component coupling and cyclization reactions

  Hiroaki Ohno; Yusuke Ohta; Shinya Oishi; Nobutaka Fujii

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, Peer-reviewed

  
• Bromoallenes as allyl dication equivalents in the presence or absence of palladium(0): Direct construction of bicyclic sulfamides containing five- to eight-membered rings by tandem cyclization of bromoallenes

  Hisao Hamaguchi; Shohei Kosaka; Hiroaki Ohno; Nobutaka Fujii; Tetsuaki Tanaka

  CHEMISTRY-A EUROPEAN JOURNAL, 2007, Peer-reviewed

  
• Structure-activity relationship study on small peptidic GPR54 agonists

  Kenji Tomita; Ayumu Niida; Shinya Oishi; Hiroaki Ohno; Jerome Cluzeau; Jean-Marc Navenot; Zi-xuan Wang; Stephen C. Peiper; Nobutaka Fujii

  BIOORGANIC & MEDICINAL CHEMISTRY, Nov. 2006, Peer-reviewed

  
• Construction of tricyclic enone, a common precursor for aphidicolane and stemodane B/C/D-ring system

  Tetsuaki Tanaka; Sachiko Yamamoto; Kei Hiramatsu; Kazuo Murakami; Hitoshi Yoshino; Debasis Patra; Chuzo Iwata; Hiroaki Ohno

  CHEMICAL & PHARMACEUTICAL BULLETIN, Aug. 2006, Peer-reviewed

  
• Vinylaziridines in Organic Synthesis

  Hiroaki Ohno

  Aziridines and Epoxides in Organic Synthesis, 15 May 2006, Peer-reviewed

  
• Synthesis of (Z)-alkene and (E)-fluoroalkene-containing diketopiperazine mimetics utilizing organocopper-mediated reduction-alkylation and diastereoselectivity examination using DFT calculations

  Ayumu Niida; Makiko Mizumoto; Tetsuo Narumi; Eriko Inokuchi; Shinya Oishi; Hiroaki Ohno; Akira Otaka; Kazuo Kitaura; Nobutaka Fujii

  JOURNAL OF ORGANIC CHEMISTRY, May 2006, Peer-reviewed

  
• Stereoselective synthesis of 3,6-disubstituted-3,6-dihydropyridin-2-ones as potential diketopiperazine mimetics using organocopper-mediated anti-S(N)2 ' reactions and their use in the preparation of low-molecule CXCR4 antagonists

  A Niida; H Tanigaki; E Inokuchi; Y Sasaki; S Oishi; H Ohno; H Tamamura; ZX Wang; SC Peiper; K Kitaura; A Otaka; N Fujii

  JOURNAL OF ORGANIC CHEMISTRY, May 2006, Peer-reviewed

  
• Potassium carbonate-promoted stereospecific 5-Endo-Trig cyclization of unactivated allenes in the absence of any transition metals

  H Ohno; Y Kadoh; N Fujii; T Tanaka

  ORGANIC LETTERS, Mar. 2006, Peer-reviewed

  
• A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres

  Tetsuo Narumi; Ayumu Niida; Kenji Tomita; Shinya Oishi; Akira Otaka; Hiroaki Ohno; Nobutaka Fujii

  CHEMICAL COMMUNICATIONS, 2006, Peer-reviewed

  
• Development of useful reactions based on the novel reactivities of allenic compounds and their application to tandem cyclizations

  H Ohno

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Dec. 2005, Peer-reviewed

  
• Development of useful reactions involving tandem cyclizations based on the novel reactivities of allenic compounds

  H Ohno

  CHEMICAL & PHARMACEUTICAL BULLETIN, Oct. 2005, Peer-reviewed

  
• Chemo- and stereoselectivity in titanium-mediated regioselective ring-opening reaction of epoxides at the more substituted carbon

  T Tanaka; K Hiramatsu; Y Kobayashi; H Ohno

  TETRAHEDRON, Jul. 2005, Peer-reviewed

  
• Palladium(0)-catalyzed tandem cyclization of allenenes: Direct construction of tricyclic heterocycles through aromatic C-H activation

  H Ohno; K Miyamura; T Mizutani; Y Kadoh; Y Takeoka; H Hamaguchi; T Tanaka

  CHEMISTRY-A EUROPEAN JOURNAL, Jun. 2005, Peer-reviewed

  
• Bromoallenes as allyl dication equivalents in the absence of palladium(0): Synthesis of bicyclic sulfamides by tandem cyclization of bromoallenes

  H Hamaguchi; S Kosaka; H Ohno; T Tanaka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Feb. 2005, Peer-reviewed

  
• Thermal intramolecular [2+2] cycloaddition of allenenes and allenynes: Diastereoselective access to bicyclic nitrogen heterocycles

  H Ohno; T Mizutani; Y Kadoh; K Miyamura; T Tanaka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, Peer-reviewed

  
• Palladium-catalyzed tandem cyclization of bromoenynes through aromatic C-H bond functionalization

  H Ohno; M Yamamoto; M Iuchi; T Tanaka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, Peer-reviewed

  
• Evaluation of scopadulciol-related molecules for their stimulatory effect on the cytotoxicity of acyclovir and ganciclovir against herpes simplex virus type 1 thymidine kinase gene-transfected HeLa cells

  K Hayashi; SMA Rahman; H Ohno; T Tanaka; N Toyooka; H Nemoto; T Hayashi

  CHEMICAL & PHARMACEUTICAL BULLETIN, Aug. 2004, Peer-reviewed

  
• Palladium(0)-catalyzed synthesis of medium-sized heterocycles by using bromoallenes as an allyl dication equivalent

  H Ohno; H Hamaguchi; M Ohata; S Kosaka; T Tanaka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2004, Peer-reviewed

  
• Palladium(0)-catalyzed stereoselective cyclization of allenenes: Divergent synthesis of pyrrolidines and 3-azabicyclo[3.1.0]hexanes from single allenenes

  H Ohno; Y Takeoka; Y Kadoh; K Miyamura; T Tanaka

  JOURNAL OF ORGANIC CHEMISTRY, Jun. 2004, Peer-reviewed

  
• Asymmetric construction of quaternary carbon centers by allyltitanium-mediated stereospecific ring-opening reaction of 2,3-epoxy alcohols.

  大野 浩章

  Tetrahedron Lett. 45/1, 75–78, 2004, Peer-reviewed

  
• Stereodivergent synthesis of chiral 2-alkenylaziridines: Palladium(0)-catalyzed 2,3-cis-selective aziridination and base-mediated 2,3-trans-selective aziridination

  H Ohno; Y Takemoto; N Fujii; T Tanaka; T Ibuka

  CHEMICAL & PHARMACEUTICAL BULLETIN, Jan. 2004, Peer-reviewed

  
• Asymmetric construction of quaternary carbon centers by titanium-mediated stereospecific allylation of 2,3-epoxy alcohol derivatives

  H Ohno; K Hiramatsu; T Tanaka

  TETRAHEDRON LETTERS, Jan. 2004, Peer-reviewed

  
• The first samarium(II)-mediated aryl radical cyclisation onto an aromatic ring

  H Ohno; H Iwasaki; T Eguchi; T Tanaka

  CHEMICAL COMMUNICATIONS, 2004, Peer-reviewed

  
• Novel synthesis of 3-azabicyclo[3.1.0]hexanes by unusual palladium(0)-catalyzed cyclopropanation of allenenes

  H Ohno; Y Takeoka; K Miyamura; Y Kadoh; T Tanaka

  ORGANIC LETTERS, Dec. 2003, Peer-reviewed

  
• Novel synthesis of azocine, azepine, oxocine, and oxepine derivatives by palladium-catalyzed medium-ring formation from bromoallenes

  H Ohno; H Hamaguchi; M Ohata; S Kosaka; T Tanaka

  HETEROCYCLES, Dec. 2003, Peer-reviewed

  
• Samarium(II)-promoted radical spirocyclization onto an aromatic ring

  H Ohno; M Okumura; S Maeda; H Iwasaki; R Wakayama; T Tanaka

  JOURNAL OF ORGANIC CHEMISTRY, Oct. 2003, Peer-reviewed

  
• Radical cyclization by ipso substitution of the methoxy group: Considerable effect of HMPA on samarium-mediated cyclization

  H Ohno; R Wakayama; S Maeda; H Iwasaki; M Okumura; C Iwata; H Mikamiyama; T Tanaka

  JOURNAL OF ORGANIC CHEMISTRY, Jul. 2003, Peer-reviewed

  
• Palladium(0)-catalyzed tandem cyclization allenenes

  H Ohno; K Miyamura; Y Takeoka; T Tanaka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, Peer-reviewed

  
• Bromoallenes as synthetic equivalents of allyl dications: Synthesis of medium-sized nitrogen heterocycles through the cyclization of bromoallenes in the presence of a palladium(o) catalyst and an alcohol

  H Ohno; H Hamaguchi; M Ohata; T Tanaka

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, Peer-reviewed

  
• A highly cis-selective synthesis of 2-ethynylaziridines by intramolecular amination of chiral bromoallenes: Improvement of stereoselectivity based on the computational investigation

  H Ohno; K Ando; H Hamaguchi; Y Takeoka; T Tanaka

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2002, Peer-reviewed

  
• Asymmetric synthesis of beta(2,3)-amino acids by InI-Pd(0)-promoted metalation and addition of chiral 2-vinylaziridines

  M Anzai; R Yanada; N Fujii; H Ohno; T Ibuka; Y Takemoto

  TETRAHEDRON, Jun. 2002, Peer-reviewed

  
• Synthesis of allenes from allylic alcohol derivatives bearing a bromine atom using a palladium(0)/diethylzinc system

  H Ohno; K Miyamura; T Tanaka; S Oishi; A Toda; Y Takemoto; N Fujii; T Ibuka

  JOURNAL OF ORGANIC CHEMISTRY, Feb. 2002, Peer-reviewed

  
• The first samarium(II)-mediated stereoselective spirocyclization onto an aromatic ring

  H Ohno; S Maeda; M Okumura; R Wakayama; T Tanaka

  CHEMICAL COMMUNICATIONS, 2002, Peer-reviewed

  
• Improved method of an unusual conversion of aliphatic amines into alcohols

  SMA Rahman; H Ohno; T Tanaka

  TETRAHEDRON LETTERS, Nov. 2001, Peer-reviewed

  
• Total synthesis of (+/-)-stemodinone via an efficient ring-exchange strategy

  T Tanaka; K Murakami; A Kanda; D Patra; S Yamamoto; N Satoh; SW Kim; SMA Rahman; H Ohno; C Iwata

  JOURNAL OF ORGANIC CHEMISTRY, Oct. 2001, Peer-reviewed

  
• Development of aziridination and azetizination reactions of amino allenes using a palladium catalyst

  H Ohno

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Oct. 2001, Peer-reviewed

  
• Stereoselective synthesis of chiral 2,3-cis-2-ethynylaziridines by base-mediated intramolecular amination of bromoallenes

  Hiroaki Ohno; Hisao Hamaguchi; Tetsuaki Tanaka

  Organic Letters, 26 Jul. 2001, Peer-reviewed

  
• Total synthesis of (±)-scopadulin

  S. M.A. Rahman; H. Ohno; T. Murata; H. Yoshino; N. Satoh; K. Murakami; D. Patra; C. Iwata; N. Maezaki; T. Tanaka

  Journal of Organic Chemistry, 13 Jul. 2001, Peer-reviewed

  
• Stereoselective synthesis of 2-alkenylaziridines and 2-alkenylazetidines by palladium-catalyzed intramolecular amination of alpha- and beta-amino allenes

  H Ohno; M Anzai; A Toda; S Ohishi; N Fujii; T Tanaka; Y Takemoto; T Ibuka

  JOURNAL OF ORGANIC CHEMISTRY, Jul. 2001, Peer-reviewed

  
• 2-Ethynylaziridines as chiral carbon nucleophiles: Stereoselective synthesis of 1,3-amino alcohols with three stereocenters via allenylindium reagents bearing a protected amino group

  H Ohno; H Hamaguchi; T Tanaka

  JOURNAL OF ORGANIC CHEMISTRY, Mar. 2001, Peer-reviewed

  
• Stereoselective synthesis of nonracemic 1,3-amino alcohols from chiral 2-vinylaziridines by InP-Pd(0)-promoted metalation

  Y Takemoto; M Anzai; R Yanada; N Fujii; H Ohno; T Ibuka

  TETRAHEDRON LETTERS, Feb. 2001, Peer-reviewed

  
• The first total synthesis of (+/-)-scopadulin, an antiviral aphidicolane diterpene

  SMA Rahman; H Ohno; T Murata; H Yoshino; N Satoh; K Murakami; D Patra; C Iwata; N Maezaki; T Tanaka

  ORGANIC LETTERS, Feb. 2001, Peer-reviewed

  
• A model study for the total synthesis of (+/-)-scopadulin: stereoselective construction of the A/B ring system with desired functionalities

  SMA Rahman; H Ohno; H Yoshino; N Satoh; M Tsukaguchi; K Murakami; C Iwata; N Maezaki; T Tanaka

  TETRAHEDRON, Jan. 2001, Peer-reviewed

  
• Efficient one-step conversion of primary aliphatic amines into primary alcohols: Application to a model study for the total synthesis of (+/-)-scopadulin

  SMA Rahman; H Ohno; N Maezaki; C Iwata; T Tanaka

  ORGANIC LETTERS, Sep. 2000, Peer-reviewed

  
• Umpolung of chiral 2-ethynylaziridines: Indium(I)-mediated stereoselective synthesis of nonracemic 1,3-amino alcohols bearing three chiral centers, catalyzed by palladium(0)

  H Ohno; H Hamaguchi; T Tanaka

  ORGANIC LETTERS, Jul. 2000, Peer-reviewed

  
• Z-selective Horner-Wadsworth-Emmons reaction of ethyl (diarylphosphono)acetates using sodium iodide and DBU

  K Ando; T Oishi; M Hirama; H Ohno; T Ibuka

  JOURNAL OF ORGANIC CHEMISTRY, Jul. 2000, Peer-reviewed

  
• Novel synthesis of chiral terminal allenes via palladium(0)-catalyzed reduction of mesylates of 2-bromoalk-2-en-1-ols bearing a protected amino group, using diethylzinc

  H Ohno; A Toda; S Oishi; T Tanaka; Y Takemoto; N Fujii; T Ibuka

  TETRAHEDRON LETTERS, Jun. 2000, Peer-reviewed

  
• Stereoselective synthesis of chiral amino allenes by organocopper-mediated anti-S(N)2 '-substitution reaction of chiral ethynylaziridines

  H Ohno; A Toda; N Fujii; Y Takemoto; T Tanaka; T Ibuka

  TETRAHEDRON, Apr. 2000, Peer-reviewed

  
• Unusual radical ipso-substitution reaction of an aromatic methoxy group induced by tris(trimethylsilyl)silane-AIBN or SmI2

  T Tanaka; R Wakayama; S Maeda; H Mikamiyama; N Maezaki; H Ohno

  CHEMICAL COMMUNICATIONS, 2000, Peer-reviewed

  
• Convenient syntheses of chiral 3-substituted 2-ethynylaziridines

  H Ohno; A Toda; Y Takemoto; N Fujii; T Ibuka

  JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, Oct. 1999, Peer-reviewed

  
• Palladium-catalyzed regio- and stereoselective synthesis of N-protected 2,4-dialkylated azacyclobutanes from amino allenes

  M Anzai; A Toda; H Ohno; Y Takemoto; N Fujii; T Ibuka

  TETRAHEDRON LETTERS, Oct. 1999, Peer-reviewed

  
• Regiospecific ring-opening reactions of beta-aziridinyl alpha,beta-enoates with acids: application to the stereoselective synthesis of a couple of diastereoisomeric (E)-alkene dipeptide isosteres from a single beta-aziridinyl alpha,beta-enoate and to the convenient preparation of amino alcohols bearing alpha,beta-unsaturated ester groups

  H Tamamura; M Yamashita; Y Nakajima; K Sakano; A Otaka; H Ohno; T Ibuka; N Fujii

  JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, Oct. 1999, Peer-reviewed

  
• Selective synthesis of cis-2-vinyl-3-alkylaziridines and 3-pyrrolines from common intermediates (Z)-4-N arylsulfonylaminoalk-2-en-1-ols

  K Ishii; H Ohno; Y Takemoto; E Osawa; Y Yamaoka; N Fujii; T Ibuka

  JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, Aug. 1999, Peer-reviewed

  
• First palladium-catalyzed aziridination reaction of amino allenes

  H Ohno; A Toda; Y Miwa; T Taga; E Osawa; Y Yamaoka; N Fujii; T Ibuka

  JOURNAL OF ORGANIC CHEMISTRY, Apr. 1999, Peer-reviewed

  
• Sterically congested chiral activated aziridines: Synthesis of both 2,3-cis- and 2,3-trans-2-alkenyl-3-alkylaziridines from common intermediates

  H Ohno; A Toda; N Fujii; Y Miwa; T Taga; Y Yamaoka; E Osawa; T Ibuka

  TETRAHEDRON LETTERS, Feb. 1999, Peer-reviewed

  
• Selective synthesis of nonracemic 3-pyrrolines and 2,3-cis-2-vinylaziridines from (Z)-amino allylic alcohols: A new synthetic route to chiral 3,4-dehydroproline

  K Ishii; H Ohno; Y Takemoto; T Ibuka

  SYNLETT, Feb. 1999, Peer-reviewed

  
• Synthesis of chiral amino allenes via an organocyanocuprate-mediated ring-opening reaction of enantiopure ethynylaziridines

  H Ohno; A Toda; Y Miwa; T Taga; N Fujii; T Ibuka

  TETRAHEDRON LETTERS, Jan. 1999, Peer-reviewed

  
• Totally stereocontrolled synthetic routes for (E)-alkene dipeptide isosteres

  N Fujii; T Ibuka; N Mimura; H Tamamura; A Otaka; H Ohno; H Aoyama; K Okano; M Hirohashi

  PEPTIDE SCIENCE - PRESENT AND FUTURE, 1999, Peer-reviewed

  
• A convenient synthesis of activated enantiomerically pure 2-ethynylaziridines

  H Ohno; A Toda; N Fujii; T Ibuka

  TETRAHEDRON-ASYMMETRY, Nov. 1998, Peer-reviewed

  
• A 2,3-cis-selective synthesis of aziridines bearing a vinyl group from allyl methyl carbonates and allyl mesylates

  H Ohno; K Ishii; A Honda; H Tamamura; N Fujii; Y Takemoto; T Ibuka

  JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, Nov. 1998, Peer-reviewed

  
• Reactions of N-arylsulfonyl-2,3-cis- and N-arylsulfonyl-2,3-trans-3-alkyl-2-vinylaziridines with organocopper reagents: Importance of 2,3-cis-stereochemistry in controlling regio- and stereoselectivity

  A Toda; H Aoyama; N Mimura; H Ohno; N Fujii; T Ibuka

  JOURNAL OF ORGANIC CHEMISTRY, Oct. 1998, Peer-reviewed

  
• Rhodium(I)- or iridium(I)-mediated equilibrated reactions of activated 2,3-cis- and trans-3-alkyl-2-vinylaziridines

  A Honda; H Ohno; N Mimura; T Ibuka

  SYNLETT, Sep. 1998, Peer-reviewed

  
• Regiospecific ring-opening reactions of aziridines bearing an alpha,beta-unsaturated ester group with trifluoroacetic acid or methanesulfonic acid: application to the stereoselective synthesis of (E)-alkene dipeptide isosteres

  H Tamamura; M Yamashita; H Muramatsu; H Ohno; T Ibuka; A Otaka; N Fujii

  CHEMICAL COMMUNICATIONS, Dec. 1997, Peer-reviewed

  
• Regio- and stereoselectivity in reactions of 2,3-cis- and trans-3-alkyl-2-vinylaziridines with organocopper reagents: Importance of 2,3-cis-stereochemistry in controlling selectivity

  H Aoyama; N Mimura; H Ohno; K Ishii; A Toda; H Tamamura; A Otaka; N Fujii; T Ibuka

  TETRAHEDRON LETTERS, Oct. 1997, Peer-reviewed

  
• Palladium-catalyzed reductive ring opening with formic acid of aziridines bearing an alpha,beta-unsaturated ester group

  H Ohno; N Mimura; A Otaka; H Tamamura; N Fujii; T Ibuka; Shimizu, I; A Satake; Y Yamamoto

  TETRAHEDRON, Sep. 1997, Peer-reviewed

  
• Palladium(0)-catalyzed isomerization reactions of aziridines bearing an alpha,beta-unsaturated ester group: A thermodynamic preference for chiral alkyl (2E)-4,5-cis-4,5-epimino-N-(alkyl- or arylsulfonyl) 2-enoates over the other three stereoisomers

  T Ibuka; N Mimura; H Ohno; K Nakai; M Akaji; H Habashita; H Tamamura; Y Miwa; T Taga; N Fujii; Y Yamamoto

  JOURNAL OF ORGANIC CHEMISTRY, May 1997, Peer-reviewed

  
• A thermodynamic preference of chiral N-methanesulfonyl and N-arenesulfonyl 2,3-cis-3-alkyl-2-vinylaziridines over their 2,3-trans-isomers: Useful palladium(0)-catalyzed equilibration reactions for the synthesis of (E)-alkene dipeptide isosteres

  T Ibuka; N Mimura; H Aoyama; M Akaji; H Ohno; Y Miwa; T Taga; K Nakai; H Tamamura; N Fujii; Y Yamamoto

  JOURNAL OF ORGANIC CHEMISTRY, Feb. 1997, Peer-reviewed

  

Misc.

• 京大薬・医薬基盤研の連携による未踏創薬分野の開拓

  大野 浩章; 秋葉 宏樹; 金尾 英佑; 石濱 泰

  MEDCHEM NEWS, Sep. 2024, Peer-reviewed, Invited

  
• 鏡像VHH抗体の免疫原性評価と免疫ライブラリーを用いた配列取得

  眞鍋麻彩子; 前田佳夕; 青木啓輔; 薄井友輔; 高橋里菜; 大野浩章; 森瀬譲二; 岡昌吾; 大石真也; 野中元裕

  日本生化学会大会(Web), 2022

  
• Construction of Quaternary Carbon Stereocenter of α-Tertiary Amine of Avionin Moiety and Synthetic Study of Microvionin

  山口亞由太; 井貫晋輔; 有地法人; 大石真也; 大野浩章

  日本薬学会年会要旨集(Web), 2023

  
• Synthetic Study of Imuune Checkpoint Molecules

  岩本直也; 佐々木順平; 青木啓輔; 井貫晋輔; 大野浩章; 大石真也; 大石真也

  日本薬学会年会要旨集(Web), 2023

  
• Synthetic Studies on Mirror-image Monobody and Their Application to a Novel Antibody Mimetic

  佐藤志乃; 岩本直也; 眞鍋麻彩子; 井貫晋輔; 大野浩章; 野中元裕; 大石真也

  日本薬学会年会要旨集(Web), 2023

  
• Identification of a novel MR1 ligand by screening with split-luciferase and its structure-activity relationship study

  松岡巧朗; 服部明; 大石真也; 有地法人; 掛谷秀昭; 山崎晶; 山崎晶; 大野浩章; 井貫晋輔

  メディシナルケミストリーシンポジウム講演要旨集, 2022

  
• Synthetic studies on mirror-image monobodies and their biological evaluations

  佐藤志乃; 岩本直也; 眞鍋麻彩子; 井貫晋輔; 大野浩章; 野中元裕; 大石真也; 大石真也

  メディシナルケミストリーシンポジウム講演要旨集, 2022

  
• Peptide probes containing a non-hydrolyzable phosphotyrosine-mimetic residue for tyrosine phosphatomics

  新苗智也; 津曲和哉; 津曲和哉; 今見考志; 杉山直幸; 大石真也; 大石真也; 大野浩章; 大高章; 石濱泰

  日本分子生物学会年会プログラム・要旨集(Web), 2021

  
• 正電荷コレステロール誘導体を用いて調製した脂質ナノ粒子製剤によるがん細胞へのsiRNA及びプラスミドDNAの導入

  竹内のぞみ; 服部喜之; 町田曜子; 八木彩奈; 長島由佳; 本田真歩; 大野浩章; 藤井信孝; 大西啓

  遺伝子・デリバリー研究会シンポジウム要旨集, 2016

  
• 新規正電荷コレステロール誘導体を用いて調製した脂質ナノ粒子製剤によるがん細胞へのsiRNA送達

  服部喜之; 中村司; 大野浩章; 藤井信孝; 米谷芳枝

  遺伝子・デリバリー研究会シンポジウム要旨集, 2013

  
• 正電荷コレステロール誘導体を用いて調製したリポソーム製剤による肝臓へのsiRNA導入

  町田曜子; 服部喜之; 本田真歩; 大野浩章; 藤井信孝; 大西啓

  遺伝子・デリバリー研究会シンポジウム要旨集, 2016

  
• Total Synthesis of (±)-Stemodinone via an EfficientRing-Exchange Strategy

  Tanaka Tetsuaki; Murakami Kazuo; Kanda Atsushi; Patra; Debasis; Yamamoto Sachiko; Satoh Norifumi; Kim Sang-Won; Rahman S.M.Abdur Rahman; Ohno Hiroaki; Iwata Chuzo

  Pharmaceutical bulletin of Josai University, 31 Jan. 2003

  
• Functional Characterization of Kisspeptin Receptor Ligands : Activation of Neuropeptide FF Receptors

  MISU Ryosuke; OISHI Shinya; TOMITA Kenji; SETSUDA Shohei; MASUDA Ryo; OHNO Hiroaki; NANIWA Yousuke; IEDA Nahoko; INOUE Naoko; OHKURA Satoshi; UENOYAMA Yoshihisa; TSUKAMURA Hiroko; MAEDA Kei-ichiro; HIRASAWA Akira; TSUJIMOTO Gozoh; FUJII Nobutaka

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011

  
• Stereoselective Synthesis of Tyr-Orn Type Alkene Dipeptide Isosteres and Their Application to Bioactive Peptides

  KOBAYASHI Kazuya; HAYASHI Ryoko; TOMITA Kenji; OISHI Shinya; OHNO Hiroaki; FUJII Nobutaka

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011

  
• Synthetic Studies on Coibamide A

  NABIKA Ryota; OISHI Shinya; INOKUCHI Eriko; OHNO Hiroaki; FUJII Nobutaka

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011

  
• A Novel Oxazolidine Linker for the Synthesis of Peptide Aldehydes

  TANAKA Michinori; OISHI Shinya; OHNO Hiroaki; FUJII Nobutaka

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2007

  
• Diastereoselective Synthesis of (Z)-Fluoroalkene Dipeptide Isostere and the Application to a HIV Membrane Fusion Inhibitor

  KAMITANI Hirotaka; KODERA Yasuyo; WATANABE Kentaro; NARUMI Tetsuo; OHNO Hiroaki; OISHI Shinya; FUJII Nobutaka

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2009

  
• Diastereoselective Synthesis of Trifluoromethylalkene Dipeptide Isosteres Based on Nucleophilic Trifluoromethylation

  KOBAYASHI Kazuya; NARUMI Tetsuo; OISHI Shinya; OHNO Hiroaki; FUJII Nobutaka

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2009

  
• Identification of Novel HIV-1 Fusion Inhibitors by Template-Assisted Peptide Aldehyde Ligation

  TANAKA Michinori; WATANABE Kentaro; OHNO Hiroaki; IZUMI Kazuki; KODAMA Eiichi; MATSUOKA Masao; OISHI Shinya; FUJII Nobutaka

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2009

  
• Structure Activity Relationship Study of the Helix-inducible Motifs in HIV Fusion Inhibitors

  WATANABE Kentaro; ITO Saori; OHNO Hiroaki; IZUMI Kazuki; KODAMA Eiichi; MATSUOKA Masao; OISHI Shinya; FUJII Nobutaka

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2009

  
• Bioorganic Synthesis of End-capped HIV-1 Fusion Inhibitor SC35EK

  KAJIWARA Kazumi; TOKIWA Rei; WATANABE Kentaro; OHNO Hiroaki; IZUMI Kazuki; KODAMA Eiichi; MATSUOKA Masao; OISHI Shinya; FUJII Nobutaka

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2009

  
• X-ray Crystallographic Study of the HIV-1 Fusion Inhibitor against the Drug-Resistant N43D Variant

  WATABE Tsuyoshi; OISHI Shinya; WATANABE Kentaro; OHNO Hiroaki; NAKANO Hiroaki; NAKATSU Toru; KATO Hiroaki; IZUMI Kazuki; KODAMA Eiichi; MATSUOKA Masao; FUJII Nobutaka

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2009

  
• Development of Novel GPR54 Agonists with Resistance to Degradation by MMP

  TOMITA Kenji; OISHI Shinya; OHNO Hiroaki; FUJII Nobutaka

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2009

  
• Synthesis of Alkene Type Dipeptide Isosteres and Their Use to Probe the Structural Requirements of Peptide Transporter (PEPT1)

  NIIDA Ayumu; TOMITA Kenji; TANIGAKI Hiroaki; TERADA Tomohiro; MIZUMOTO Makiko; OHNO Hiroaki; TAMAMURA Hirokazu; OTAKA Akira; INUI Ken-ichi; FUJII Nobutaka

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2006

  
• Endeavors for Highly Stereoselective Synthesis of Functionalized Fluoroalkene Dipeptide Isosteres

  NARUMI Tetsuo; NIIDA Ayumu; TOMITA Kenji; OISHI Shinya; OHNO Hiroaki; OTAKA Akira; FUJII Nobutaka

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2006

  
• Structure-Activity Relationship Study on hOT7T175 Agonist with RW-Amide

  TOMITA Kenji; NIIDA Ayumu; OISHI Shinya; OHNO Hiroaki; OTAKA Akira; FUJII Nobutaka

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2006

  
• Peptide probes containing a non-hydrolyzable phosphotyrosine-mimetic residue toward tyrosine phosphatome analysis

  新苗智也; 津曲和哉; 津曲和哉; 今見考志; 杉山直幸; 大石真也; 大石真也; 大野浩章; 大高章; 石濱泰

  バイオメディカル分析科学シンポジウム講演要旨集, 2021

  
• Synthesis of Lysine Derivatives and the Application to SAR Study on Coibamide A

  鈴木力斗; 喜多村隆志; 井貫晋輔; 大野浩章; 大石真也; 大石真也

  日本薬学会年会要旨集(Web), 2021

  
• Synthetic Study of Picrinine Based on Gold(I)-Catalyzed Cascade Cyclization

  橋本直季; 田口淳一; 大石真也; 井貫晋輔; 大野浩章

  日本薬学会年会要旨集(Web), 2021

  
• Construction of a fused indolenine scaffold via hydroarylation of alkynes using a gold catalyst

  島恭平; 大石真也; 井貫晋輔; 大野浩章

  日本薬学会年会要旨集(Web), 2021

  
• 可視光レドックス触媒を用いたラジカルipso環化反応を鍵とするZephycarinatine CおよびDの全合成

  井貫晋輔; 竹内春佳; 中川航平; 川邊隆彰; 市村敦彦; 大石真也; 大野浩章

  反応と合成の進歩シンポジウム講演要旨集, 2020

  
• Synthetic Study of TIGIT Extracellular Domain Using C-to-N Sequential NCL Protocol

  岩本直也; 佐々木順平; 青木啓輔; 井貫晋輔; 大野浩章; 大石真也

  日本薬学会年会要旨集(CD-ROM), 2020

  
• Structure activity relationship study of ck2 inhibitors with a pyrazole scaffold by nitrogen scan

  奥村政輝; 中西伸介; 栗本泰奈; 西脇敬二; 中村真也; 大石真也; 大野浩章; 仲西功

  日本薬学会年会要旨集(CD-ROM), 2020

  
• XIAP BIR3ドメインの化学合成と鏡像スクリーニングへの応用

  岩本直也; 周敬棠; 本田香織; 近藤恭光; 長田裕之; 井貫晋輔; 大野浩章; 藤井信孝; 大石真也

  日本薬学会年会要旨集(CD-ROM), 2019

  
• 鏡像スクリーニングを指向したTIGITタンパク質の合成研究

  青木啓輔; 佐々木順平; 井貫晋輔; 大野浩章; 大石真也

  日本薬学会年会要旨集(CD-ROM), 2019

  
• Tris誘導体に対する遠隔位C-H結合官能基化反応を鍵としたmyriocinの不斉全合成

  井貫晋輔; 宮川貴吏; 大石真也; 大野浩章

  反応と合成の進歩シンポジウム講演要旨集, 2019

  
• 金触媒による連続環化反応を用いた八員環縮環インドールとプロペラン型インドリンの選択的構築法の開発

  山口亞由太; 井貫晋輔; 時水勇輔; 大石真也; 大野浩章

  反応と合成の進歩シンポジウム講演要旨集, 2019

  
• 可視光レドックス触媒を利用した糖誘導体からのアルジトール類の合成とその応用

  松岡巧朗; 井貫晋輔; 宮川貴吏; 大石真也; 大野浩章

  反応と合成の進歩シンポジウム講演要旨集, 2019

  
• Dictyodendrin類の多様性指向型全合成

  松岡純平; 松田優佳; 川田惟樹; 井貫晋輔; 大石真也; 大野浩章

  日本分析化学会有機微量分析研究懇談会・計測自動制御学会力学量計測部会合同シンポジウム講演要旨集, 2019

  
• 金触媒連続環化反応を基盤としたAspidophylline Aの全合成研究

  田口淳一; 奥村怜司; 大原礼子; 井貫晋輔; 大石真也; 大野浩章

  日本分析化学会有機微量分析研究懇談会・計測自動制御学会力学量計測部会合同シンポジウム講演要旨集, 2019

  
• Structure-activity relationship study of CK2 inhibitors with a pyrazole scaffold by nitrogen scan

  奥村政輝; 中西伸介; 栗本泰奈; 西脇敬二; 中村真也; 大石真也; 大野浩章; 仲西功

  構造活性相関シンポジウム講演要旨集, 2019

  
• カプシドタンパク質の化学合成と粒子形成の最適化

  佐々木順平; 石場勲之; 津田修吾; 西尾秀喜; 片岡紀代; 渡士幸一; 井貫晋輔; 大野浩章; 大石真也

  日本薬学会年会要旨集(CD-ROM), 2018

  
• 化合物アレイの新たな活用法:天然物の鏡像体化合物群の活用を目指したスクリーニング法の開発

  近藤恭光; 野口太朗; 大石真也; 本田香織; 大野浩章; 藤井信孝; 長田裕之

  日本農芸化学会大会講演要旨集(Web), 2017

  
• 鏡像体タンパク質を利用したc-Src SH2ドメイン阻害剤の探索法の開発

  周敬棠; 野口太朗; 本田香織; 近藤恭光; 長田裕之; 大野浩章; 藤井信孝; 大石真也

  日本薬学会年会要旨集(CD-ROM), 2017

  
• CXCR7受容体選択的リガンドの構造活性相関研究

  関口遼; 黒柳友子; 小林由佳; 小林数也; 赤路健一; 藤井信孝; 大野浩章; 大石真也

  メディシナルケミストリーシンポジウム講演要旨集, 2017

  
• キラルな天然有機化合物の鏡像体群をリソースとしたMDM2-p53間相互作用阻害剤の探索

  野口太朗; 大石真也; 本田香織; 近藤恭光; 斎藤臣雄; 大野浩章; 長田裕之; 藤井信孝

  メディシナルケミストリーシンポジウム講演要旨集, 2015

  
• SmI₂を用いた芳香環へのラジカルスピロ環化反応

  大野浩章; 岩崎宏樹; 奥村光晶; 前田真一郎; 田中徹明

  反応と合成の進歩シンポジウム講演要旨集, 24 Sep. 2003

  
• SYNTHETIC STUDY OF ODOAMIDE AND ITS DERIVATIVES

  M. Kaneda; S. Oishi; K. Sueyoshi; T. Teruya; H. Ohno; N. Fujii

  JOURNAL OF PEPTIDE SCIENCE, Sep. 2016

  
• 長時間作用型PEG化NK3受容体作動薬の創製

  桑井真司; 大石真也; 三須良介; 大野浩章; 山村崇; 若林嘉浩; 岡村裕昭; 藤井信孝

  日本薬学会年会要旨集(CD-ROM), 2016

  
• PEG修飾による長時間作用型NK3受容体作動薬の創製

  桑井真司; 大石真也; 三須良介; 岡崎志穂; 山本昂輝; 大野浩章; 山村崇; 若林嘉浩; 岡村裕昭; 藤井信孝

  メディシナルケミストリーシンポジウム講演要旨集, 01 Nov. 2015

  
• 金触媒を用いた共役ジインの連続環化反応による縮環インドールの一挙合成

  NAOE SAORI; SAITO TATSUO; UCHIYAMA MASANOBU; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  次世代を担う有機化学シンポジウム講演要旨集, 22 May 2015

  
• 金触媒を用いた共役ジインの三連続環化反応による縮環カルバゾールの合成

  TAGUCHI MASAMITSU; TOKIMIZU YUSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集(CD-ROM), 2015

  
• 新規ニューロキニン‐3受容体アゴニストの創製と繁殖中枢制御への応用

  YAMAMOTO KOKI; OISHI SHIN'YA; MISU RYOSUKE; YAMADA AI; NOGUCHI TARO; OHNO HIROAKI; YAMAMURA TAKASHI; OKAMURA HIROAKI; MATSUDA NIKO; OKURA SATOSHI; FUJII NOBUTAKA

  日本薬学会年会要旨集(CD-ROM), 2015

  
• 天然物の鏡像体化合物群の活用を目指した新規スクリーニング法の開発

  NOGUCHI TARO; OISHI SHIN'YA; HONDA KAORI; KONDO YASUMITSU; SAITO TAMIO; OHNO HIROAKI; OSADA HIROYUKI; FUJII NOBUTAKA

  日本薬学会年会要旨集(CD-ROM), 2015

  
• 新規CXCR7選択的リガンドの創製:CXCR4拮抗剤からの受容体選択性の変換

  KUROYANAGI TOMOKO; OISHI SHIN'YA; KUBO TATSUHIKO; KOBAYASHI YUKA; MISU RYOSUKE; OHNO HIROAKI; MONTPAS NICOLAS; HEVEKER NIKOLAUS; YOSHIKAWA YASUSHI; FURUYA TOSHIO; FUJII NOBUTAKA

  日本薬学会年会要旨集(CD-ROM), 2015

  
• クロスメタセシス反応を利用したスフィンゴシンキナーゼ阻害剤の創製研究

  HONDA MAHO; MIYAGAKI JUN; YOSHIMITSU YUJI; IWATA AKIRA; OTSUKI KAZUHIRO; MARUYAMA TOORU; NAKAMURA SHIN'YA; NAKANISHI ISAO; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA

  日本薬学会年会要旨集(CD-ROM), 2015

  
• 金触媒を用いた共役ジインとピロールの分子間[4+2]型反応による4,7‐二置換インドール骨格の構築

  MATSUDA YUKA; NAOE SAORI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集(CD-ROM), 2015

  
• 鉄(II)イオン配位性ペプチドの設計と機能評価

  KOBAYASHI YUKA; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA

  日本薬学会年会要旨集(CD-ROM), 2015

  
• 新規抗HIV剤を指向したベンゾイソチアゾロピリミジン誘導体の構造活性相関研究

  OKAZAKI SHIHO; MIZUHARA TSUKASA; SHIMURA KAZUYA; MURAYAMA HIROTO; MATSUOKA MASAO; OHNO HIROAKI; OISHI SHIN'YA; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 07 Nov. 2014

  
• スフィンゴシンキナーゼ阻害活性を有するJaspine B誘導体の構造活性相関研究

  HONDA MAHO; MIYAGAKI JUN; YOSHIMITSU YUJI; IWATA AKIRA; OTSUKI KAZUHIRO; MARUYAMA TOORU; NAKAMURA SHIN'YA; NAKANISHI ISAO; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 07 Nov. 2014

  
• 環状ペンタペプチド骨格を有する新規CXCR7選択的リガンドの創製

  KUROYANAGI TOMOKO; OISHI SHIN'YA; KUBO TATSUHIKO; KOBAYASHI YUKA; MISU RYOSUKE; OHNO HIROAKI; NICOLAS MONTPAS; NIKOLAUS HEVEKER; YOSHIKAWA YASUSHI; FURUYA TOSHIO; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 07 Nov. 2014

  
• 金触媒を用いた共役ジインとピロールの分子間[4+2]型反応によるインドール骨格の構築

  MATSUDA YUKA; NAOE SAORI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  反応と合成の進歩シンポジウム講演要旨集, 22 Oct. 2014

  
• 金触媒によるアジドイナミドの連続環化反応を用いたインドロキノリン骨格の一挙構築

  TOKIMIZU YUSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  反応と合成の進歩シンポジウム講演要旨集, 22 Oct. 2014

  
• ペプチド結合のN‐メチル化反応を利用したIB‐01212の合成研究

  NAMIKAWA RYOTA; OISHI SHIN'YA; MISU RYOSUKE; OHNO HIROAKI; FUJII NOBUTAKA

  反応と合成の進歩シンポジウム講演要旨集, 22 Oct. 2014

  
• 金触媒を用いた共役ジインとピロールの分子間[4+2]型反応によるインドール骨格の構築

  MATSUDA YUKA; NAOE SAORI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  有機合成化学セミナー講演予稿集, 17 Sep. 2014

  
• 新規正電荷コレステロール誘導体を用いて調製したsiRNA送達用脂質微粒子製剤によるがん細胞での遺伝子発現抑制効果

  服部喜之; 中村文子; 南口大樹; 新宮弓美子; 原恵理子; 大野浩章; 川野久美; 藤井信孝; 米持悦生

  日本DDS学会学術集会プログラム予稿集, 01 Jul. 2014

  
• 金触媒によるアジドイナミドの連続環化反応を用いたインドロキノリン骨格の一挙構築

  TOKIMIZU YUSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  次世代を担う有機化学シンポジウム講演要旨集, 23 May 2014

  
• Binding free energy-guided design of Protein kinase CK2 inhibitors and structure-activity relationship analysis

  Nakanishi Shinsuke; Okada Hironori; Moriwaki Hirotomo; Nishiwaki Keiji; Nakamura Shinya; Kinoshita Takayoshi; Oishi Shinya; Ohno Hiroaki; Fujii Nobutaka; Nakanishi Isao

  Proceedings of the Symposium on Chemoinformatics, 2014

  
• キスペプチン受容体に対する蛍光プローブの創製研究

  KANEDA MASAHITO; OISHI SHIN'YA; MISU RYOSUKE; OHNO HIROAKI; FUJII NOBUTAKA

  日本薬学会年会要旨集(CD-ROM), 2014

  
• 金触媒を用いた共役ジインの連続環化反応による縮環インドールの一挙合成

  NAOE SAORI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集(CD-ROM), 2014

  
• NK3受容体アゴニストの生体内安定性評価と新規誘導体の創製

  MISU RYOSUKE; OISHI SHIN'YA; YAMADA AI; YAMAMOTO KOKI; NOGUCHI TARO; OHNO HIROAKI; YAMAMURA TAKASHI; OKAMURA HIROAKI; MATSUDA NIKO; OKURA SATOSHI; FUJII NOBUTAKA

  GPCR研究会プログラム・抄録集, 2014

  
• ニューロキニン‐3受容体アゴニストの構造活性相関研究

  YAMAMOTO KOKI; MISU RYOSUKE; NOGUCHI TARO; OHNO HIROAKI; OISHI SHIN'YA; YAMAMURA TAKASHI; OKAMURA HIROAKI; FUJII NOBUTAKA

  GPCR研究会プログラム・抄録集, 2014

  
• 化合物アレイを用いた新規MDM2/MDMX‐p53阻害剤の探索法の開発とその応用

  NOGUCHI TARO; OISHI SHIN'YA; HONDA KAORI; KONDO YASUMITSU; SAITO TAMIO; KUBO TATSUHIKO; KANEDA MASATO; OHNO HIROAKI; OSADA HIROYUKI; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 01 Nov. 2013

  
• 連続縮環型分子の修飾によるKSP阻害剤の溶解性改善

  TAKEUCHI TOMOKI; OISHI SHIN'YA; KANEDA MASATO; OHNO HIROAKI; NAKAMURA SHIN'YA; NAKANISHI ISAO; YAMANE MASAYOSHI; SAWADA JUN'ICHI; ASAI AKIRA; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 01 Nov. 2013

  
• 新規フェニルピラゾール誘導体の抗HIV活性に関する構造活性相関研究

  OKAZAKI SHIHO; MIZUHARA TSUKASA; KATO TAKAYUKI; HIRAI ATSUSHI; KURIHARA HIDEKI; SHIMADA YASUHIRO; TANIGUCHI MASAHIKO; MAETA HIDEKI; TOGAMI HIROAKI; SHIMURA KAZUYA; MATSUOKA MASAO; TAKEUCHI TOMOKI; OHNO HIROAKI; OISHI SHIN'YA; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 01 Nov. 2013

  
• 金触媒を用いた共役ジインの多連続環化反応による縮環インドールの一挙合成

  NAOE SAORI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  反応と合成の進歩シンポジウム講演要旨集, 15 Oct. 2013

  
• パラジウム触媒による連続環化反応を用いた四環性スピロインドール類の合成

  IWATA AKIRA; INUKI SHINSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  反応と合成の進歩シンポジウム講演要旨集, 15 Oct. 2013

  
• パラジウム触媒を用いた中員環形成反応によるLaurencia族環状エーテルの構築:Laurendecumallene Bの合成研究

  OHNO HIROAKI; YOSHIMITSU YUJI; INUKI SHINSUKE; OISHI SHIN'YA; FUJII NOBUTAKA

  反応と合成の進歩シンポジウム講演要旨集, 15 Oct. 2013

  
• 金触媒を用いたベンゾフランによる分子内ヒドロアリール化反応の検討

  SAKAI YUKI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  反応と合成の進歩シンポジウム講演要旨集, 15 Oct. 2013

  
• 金触媒を用いた三成分環化反応によるジヒドロピラゾールの合成とCK2阻害剤開発への応用

  OHNO HIROAKI; SUZUKI YAMATO; HOU ZENGYE; KURE TATSUHIDE; NAKANISHI ISAO; HIRASAWA AKIRA; OISHI SHIN'YA; FUJII NOBUTAKA

  複素環化学討論会講演要旨集, 01 Oct. 2013

  
• NK3Rアンタゴニストの多様性指向型合成法に関する検討

  MINAMIGUCHI DAIKI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  有機合成化学セミナー講演予稿集, 17 Sep. 2013

  
• Synthesis of the fused tetracyclic spiroindoles via palladium-catalyzed cascade reaction

  Akira Iwata; Shinya Oishi; Nobutaka Fujii; Hiroaki Ohno

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2013

  
• キネシンモータータンパク質KSP阻害剤の創製研究―連続縮環型分子の変換による溶解性改善―

  TAKEUCHI TOMOOKI; OISHI SHIN'YA; KANEDA MASAHITO; OHNO HIROAKI; SAWADA JUN'ICHI; ASAI AKIYOSHI; FUJII NOBUTAKA

  次世代を担う有機化学シンポジウム講演要旨集, 24 May 2013

  
• Development of Photoaffinity Probes for Characterization of the Receptor Binding Residues in Kisspeptins

  S. Oishi; S. Setsuda; R. Misu; T. Noguchi; M. Kaneda; H. Ohno; B. Evans; J. Navenot; S. C. Peiper; N. Fujii

  BIOPOLYMERS, May 2013

  
• Structure-activity Relationship Study of Tachykinin Peptides for Development of Novel Neurokinin-3 Receptor Selective Agonists

  R. Misu; S. Oishi; T. Noguchi; A. Yamada; H. Ohno; F. Matsuda; S. Ohkura; N. Fujii

  BIOPOLYMERS, May 2013

  
• 化合物アレイを用いたMDM2/MDMX‐P53阻害剤の探索法の開発

  NOGUCHI TARO; OISHI SHIN'YA; KUBO TATSUHIKO; OHNO HIROAKI; KONDO YASUMITSU; SAITO TAMIO; OSADA HIROYUKI; FUJII NOBUTAKA

  日本薬学会年会要旨集(CD-ROM), 2013

  
• デフェリフェリクリシン誘導体の合成と構造機能相関研究への応用

  KOBAYASHI YUKA; OISHI SHIN'YA; KOBAYASHI KAZUYA; OHNO HIROAKI; TSUTSUMI HIROKO; HATA YOJI; FUJII NOBUTAKA

  日本薬学会年会要旨集(CD-ROM), 2013

  
• パラジウム触媒による連続反応を用いたスピロインドール類の合成

  IWATA KEN; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集(CD-ROM), 2013

  
• 非経験的フラグメント分子軌道法を活用した高活性Protein Kinase CK2阻害剤の設計

  GO RYUEI; KO ZOYO; KINOSHITA TAKAYOSHI; TAKEI YOSHINORI; YASUE MISATO; MISU RYOSUKE; SUZUKI YAMATO; NAKAMURA SHIN'YA; OHNO HIROAKI; MURATA KATSUMI; KITAURA KAZUO; HIRASAWA AKIRA; OISHI SHIN'YA; FUJII NOBUTAKA; NAKANISHI ISAO

  構造活性相関シンポジウム講演要旨集, 12 Nov. 2012

  
• 縮環型含窒素複素環の多様性指向型合成反応の開発とCK2阻害剤の構造活性相関研究への応用

  NAOE SAORI; SUZUKI YAMATO; OISHI SHIN'YA; TAKEI YOSHINORI; YASUE MISATO; MISU RYOSUKE; HOU ZENGYE; KURE TATSUHIDE; NAKANISHI ISAO; OHNO HIROAKI; HIRASAWA AKIRA; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 01 Nov. 2012

  
• (-)‐Quinocarcinの全合成

  CHIBA HIROAKI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  反応と合成の進歩シンポジウム講演要旨集, 15 Oct. 2012

  
• パラジウム触媒によるプロパルギル化合物の中員環形成反応を利用したLaurendecumallene Bの全合成研究

  YOSHIMITSU YUJI; INUKI SHINSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  反応と合成の進歩シンポジウム講演要旨集, 15 Oct. 2012

  
• ピリミドベンゾチアジン誘導体の合成法の開発と抗HIV剤の構造活性相関研究への応用

  MIZUHARA TSUKASA; OISHI SHIN'YA; OHNO HIROAKI; SHIMURA KAZUYA; MATSUOKA MASAO; FUJII NOBUTAKA

  複素環化学討論会講演要旨集, 30 Sep. 2012

  
• フェニルアゾール骨格を有する新規プロテインキナーゼCK2阻害剤の開発

  HOU ZENGYE; OISHI SHIN'YA; TAKEI YOSHINORI; YASUE MISATO; MISU RYOSUKE; SUZUKI YAMATO; MURATA KATSUMI; KITAURA KAZUO; HIRASAWA AKIRA; TSUJIMOTO GOZO; OHNO HIROAKI; NAKANISHI ISAO; NAKAMURA SHIN'YA; KURE TATSUHIDE; KINOSHITA TAKAYOSHI; FUJII NOBUTAKA

  複素環化学討論会講演要旨集, 30 Sep. 2012

  
• 金触媒による三成分環形成反応を用いた多置換ジヒドロピラゾールの効率的合成法の開発

  NAOE SAORI; SUZUKI YAMATO; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  複素環化学討論会講演要旨集, 30 Sep. 2012

  
• Jaspine Bおよびその誘導体の多様性指向型合成研究

  MIYAGAKI JUN; YOSHIMITSU YUJI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  複素環化学討論会講演要旨集, 30 Sep. 2012

  
• ルイス酸によるジヒドロベンゾフランの環交換反応を用いた(-)‐Quinocarcinamideの形成合成

  SAKAI YUKI; CHIBA KOSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  有機合成化学セミナー講演予稿集, 05 Sep. 2012

  
• アザインドール骨格またはフェニルアゾール骨格を有する新規プロテインキナーゼCK2阻害剤の開発研究

  HOU Z; OISHI SHIN'YA; TAKEI YOSHINORI; YASUE MISATO; MISU RYOSUKE; SUZUKI YAMATO; MURATA KATSUMI; KITAURA KAZUO; HIRASAWA AKIRA; TSUJIMOTO GOZO; OHNO HIROAKI; FUJII NOBUTAKA; NAKANISHI ISAO; NAKAMURA SHIN'YA; KURE RYUEI; KINOSHITA TAKAYOSHI

  次世代を担う有機化学シンポジウム講演要旨集, 11 May 2012

  
• 抗腫瘍活性ペプチドcoibamide Aの標的同定プローブを指向した合成

  NAMIKAWA RYOTA; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA

  日本薬学会年会要旨集, 05 Mar. 2012

  
• 金触媒を用いた位置選択的なカスケード型分子間/分子内付加反応による縮合ベンゼン環の一挙構築法の開発

  NAOE SAORI; SUZUKI YAMATO; HIRANO KIMIO; INABA YUSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2012

  
• Pd触媒によるプロパルギル化合物の連続環化反応を利用した(+)‐Biotinの合成研究

  MIZUSHIMA SHINGO; INUKI SHINSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2012

  
• Jaspine Bおよびその誘導体の多様性指向型合成

  MIYAGAKI JUN; YOSHIMITSU YUJI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2012

  
• 金触媒を用いたアルキンに対する分子間求核付加‐環化反応によるナフタレン誘導体の合成

  NAOE SAORI; HIRANO KIMIO; INABA YUSUKE; SUZUKI YAMATO; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  反応と合成の進歩シンポジウム講演要旨集, 14 Oct. 2011

  
• 金触媒による三成分環形成反応を用いた多置換ジヒドロピラゾールの効率的合成法の開発

  SUZUKI YAMATO; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  反応と合成の進歩シンポジウム講演要旨集, 14 Oct. 2011

  
• リゼルグ酸および関連アルカロイドの不斉全合成

  IWATA AKIRA; INUKI SHINSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  反応と合成の進歩シンポジウム講演要旨集, 14 Oct. 2011

  
• アルケン型及びアミジン型ペプチドイソスターの合成とCXCR4拮抗剤の構造活性相関研究への応用

  KOBAYASHI KAZUYA; OISHI SHIN'YA; INOKUCHI ERIKO; HAYASHI RYOKO; TOMITA KENJI; KUBO TATSUHIKO; TANAHARA NORIKO; OHNO HIROAKI; FUJII NOBUTAKA; YOSHIKAWA YASUSHI; FURUYA TOSHIO; SHIMURA KAZUYA; MATSUOKA MASAO

  反応と合成の進歩シンポジウム講演要旨集, 14 Oct. 2011

  
• 金触媒によるアルキンのヒドロアリール化を用いた多連続環化反応の開発

  OHNO HIROAKI; HIRANO KIMIO; INABA YUSUKE; NAOE SAORI; OISHI SHIN'YA; FUJII NOBUTAKA

  複素環化学討論会講演要旨集, 30 Sep. 2011

  
• 金触媒を用いた分子内ヒドロアミノ化反応を基盤としたQuinocarcinの合成研究

  CHIBA HIROAKI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  天然有機化合物討論会講演要旨集, 02 Sep. 2011

  
• Jaspine Bおよびその誘導体の多様性指向型合成

  MIYAGAKI JUN; YOSHIMITSU YUJI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  有機合成化学セミナー講演予稿集, 31 Aug. 2011

  
• 金触媒を用いたアルキンのヒドロアリール化反応を基盤とする連続環化反応の開発

  NAOE SAORI; HIRANO KIMIO; INABA YUSUKE; SUZUKI YAMATO; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  有機合成化学セミナー講演予稿集, 31 Aug. 2011

  
• Jaspine Bおよびその誘導体の立体分岐合成と構造活性相関研究

  YOSHIMITSU YUJI; OISHI SHIN'YA; MIYAGAKI JUN; INUKI SHINSUKE; FUJII NOBUTAKA; OHNO HIROAKI

  次世代を担う有機化学シンポジウム講演要旨集, 22 May 2011

  
• GPR54リガンドによるNPFF受容体の活性化

  MISU RYOSUKE; OISHI SHIN'YA; TOMITA KENJI; SETSUDA SHOHEI; MASUDA RYO; OHNO HIROAKI; NAMBA YOSUKE; IEDA NAHOKO; INOUE NAOKO; OKURA SATOSHI; UENOYAMA YOSHIHISA; TSUKAMURA HIROKO; MAEDA KEIICHIRO; HIRASAWA AKIRA; TSUJIMOTO GOZO; FUJII NOBUTAKA

  日本薬学会年会要旨集, 05 Mar. 2011

  
• 金触媒を用いた分子内ヒドロアミノ化反応を基盤としたQuinocarcinの合成研究

  CHIBA KOSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2011

  
• 縮環インドール構造を有する新規Eg5阻害剤の開発

  TAKEUCHI TOMOTATSU; OISHI SHIN'YA; WATANABE TOSHIAKI; OHNO HIROAKI; ASADA NAOYA; KITAURA KAZUO; SAWADA JUN'ICHI; ASAI AKIYOSHI; FUJII NOBUTAKA

  日本薬学会年会要旨集, 05 Mar. 2011

  
• アルケン型ジペプチドイソスターの合成とCXCR4拮抗剤FC131の構造活性相関研究への応用

  KOBAYASHI KAZUYA; HAYASHI RYOKO; OISHI SHIN'YA; KUBO TATSUHIKO; OHNO HIROAKI; FUJII NOBUTAKA

  日本薬学会年会要旨集, 05 Mar. 2011

  
• Coibamide Aの合成研究

  NAMIKAWA RYOTA; OISHI SHIN'YA; INOKUCHI ERIKO; OHNO HIROAKI; FUJII NOBUTAKA

  日本薬学会年会要旨集, 05 Mar. 2011

  
• 銅触媒を用いたオルト無置換ベンズアミジンのアルキニル化―環化によるキナゾリンの直接的合成

  TOKIMIZU YUSUKE; OTA YUSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2011

  
• (+)‐リゼルグ酸の不斉全合成研究

  IWATA AKIRA; INUKI SHINSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2011

  
• 金触媒を用いたアニリン誘導体の連続型分子内ヒドロアミノ化―ヒドロアリール化反応による高度縮環型カルバゾール誘導体の合成

  INABA YUSUKE; HIRANO KIMIO; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2011

  
• Synthesis and Biological Evaluation of Novel CXCR4 Antagonists Containing Amidine-type Peptide Bond Isosteres

  E. Inokuchi; S. Oishi; T. Kubo; H. Ohno; K. Shimura; M. Matsuoka; N. Fujii

  BIOPOLYMERS, 2011

  
• Synthesis and Application of Fluorescent SDF-1 Derivatives

  Ryo Masuda; Shinya Oishi; Noriko Tanahara; Hiroaki Ohno; Akira Hirasawa; Gozoh Tsujimoto; Yoshiaki Yano; Katsumi Matsuzaki; Nobutaka Fujii

  BIOPOLYMERS, 2011

  
• 金触媒によるジインおよびトリイン誘導体の連続環化反応を用いた縮環型インドール誘導体の合成

  HIRANO KIMIO; INABA YUSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  有機合成シンポジウム講演要旨集, 30 Oct. 2010

  
• 縮環インドール構造を有する新規Eg5阻害剤の開発

  TAKEUCHI TOMOKI; OISHI SHIN'YA; WATANABE TOSHIAKI; OHNO HIROAKI; ASADA NAOYA; KITAURA KAZUO; SAWADA JUN'ICHI; ASAI AKIRA; FUJII NOBUTAKA

  構造活性相関シンポジウム講演要旨集, 22 Oct. 2010

  
• 連続的多成分カップリング―環化反応によるピロロインドール及びジピロロピリジン誘導体の効率的合成法の開発

  SUZUKI YAMATO; HOU ZENGYE; YASUE MISATO; HIRASAWA AKIRA; TSUJIMOTO GOZO; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 18 Oct. 2010

  
• GPR54受容体リガンドによるNPFF受容体の活性化

  SETSUDA SHOHEI; OISHI SHIN'YA; MISU RYOSUKE; TOMITA KENJI; MASUDA RYO; OHNO HIROAKI; NANIWA YOSUKE; IEDA NAHOKO; INOUE NAOKO; OKURA SATOSHI; UENOYAMA YOSHIHISA; TSUKAMURA HIROKO; MAEDA KEIICHIRO; HIRASAWA AKIRA; TSUJIMOTO GOZO; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 18 Oct. 2010

  
• 蛍光標識CXCR4受容体リガンドの創製と応用

  MASUDA RYO; OISHI SHIN'YA; TANAHARA NORIKO; OHNO HIROAKI; HIRASAWA AKIRA; TSUJIMOTO GOZO; YANO YOSHIAKI; MATSUZAKI KATSUMI; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 18 Oct. 2010

  
• 縮環インドール構造を有する新規Eg5阻害剤の開発

  TAKEUCHI TOMOKI; OISHI SHIN'YA; WATANABE TOSHIAKI; OHNO HIROAKI; ASADA NAOYA; KITAURA KAZUO; SAWADA JUN'ICHI; ASAI AKIRA; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 18 Oct. 2010

  
• アザインドール骨格を有する新規CK2阻害剤テンプレートの開発研究

  HOU ZENGYE; SUZUKI YAMATO; YASUE MISATO; HIRASAWA AKIRA; TSUJIMOTO GOZO; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA

  反応と合成の進歩シンポジウム講演要旨集, 12 Oct. 2010

  
• パラジウム触媒によるブロモアレンとプロパルギル化合物の連続環化反応を利用したJaspine Bの全合成とその応用

  INUKI SHINSUKE; YOSHIMITSU YUJI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  反応と合成の進歩シンポジウム講演要旨集, 12 Oct. 2010

  
• 遷移金属触媒を用いたSonogashiraカップリング―環化反応を鍵反応としたQuinocarcinの合成研究

  CHIBA HIROAKI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  反応と合成の進歩シンポジウム講演要旨集, 12 Oct. 2010

  
• 銅触媒を用いたオルト無置換ベンズアミジンのアルキニル化―環化によるキナゾリンの直接的合成

  TOKIMIZU YUSUKE; OTA YUSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  有機合成化学セミナー講演予稿集, 02 Sep. 2010

  
• Jaspine Bおよびその誘導体の立体選択的合成研究

  YOSHIMITSU YUJI; INUKI SHINSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2010

  
• 薬剤耐性株に有効な抗HIV活性ペプチドの創製と発現生産プロセスの開発

  OISHI SHIN'YA; KAJIWARA KAZUMI; TANAKA MICHINORI; OHNO HIROAKI; FUJII NOBUTAKA

  日本薬学会年会要旨集, 05 Mar. 2010

  
• パラジウム触媒とイソシアネートを用いた2‐アルキニルアジリジンの環拡大―連続的環化反応による連結型複素環の構築

  OKANO AKINORI; OISHI SHIN'YA; TANAKA TETSUAKI; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2010

  
• 金触媒を用いたアニリン誘導体の分子内連続環化反応による芳香族縮環型カルバゾール誘導体の合成

  INABA YUSUKE; HIRANO KIMIO; WATANABE TOSHIAKI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2010

  
• 縮環インドール構造を有する新規Eg5阻害剤の開発

  TAKEUCHI TOMOTATSU; WATANABE TOSHIAKI; OISHI SHIN'YA; OHNO HIROAKI; SAWADA JUN'ICHI; ASAI AKIYOSHI; FUJII NOBUTAKA

  日本薬学会年会要旨集, 05 Mar. 2010

  
• アルケン型ジペプチドイソスターの合成とケモカイン受容体CXCR4拮抗剤の構造活性相関研究への応用

  HAYASHI RYOKO; OISHI SHIN'YA; TOMITA KENJI; NARUMI TETSUO; TANAHARA NORIKO; OHNO HIROAKI; NAITO TAKESHI; KODAMA EIICHI; MATSUOKA MASAO; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 10 Nov. 2009

  
• 縮環インドール構造を有する新規Eg5阻害剤の開発

  TAKEUCHI TOMOKI; WATANABE TOSHIAKI; OISHI SHIN'YA; OHNO HIROAKI; SAWADA JUN'ICHI; ASAI AKIRA; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 10 Nov. 2009

  
• 銅触媒による多成分カップリング反応を用いたワンポット含窒素多環式複素環骨格構築法の開発

  OTA YUSUKE; KUBOTA YUJI; CHIBA HIROAKI; OISHI MASAYA; FUJII NOBUTAKA; OHNO HIROAKI

  反応と合成の進歩シンポジウム講演要旨集, 30 Oct. 2009

  
• 有機銅‐亜鉛複合試薬を用いたトリフルオロメチルアルケンジペプチドイソスターの新規合成法の開発

  KOBAYASHI KAZUYA; NARUMI TETSUO; INOGUCHI ERIKO; TOMITA KENJI; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA

  反応と合成の進歩シンポジウム講演要旨集, 30 Oct. 2009

  
• 銅触媒によるテトラヒドロピリミジンを配位性置換基とした酸化的分子間オルトC‐H官能基化反応

  MIZUHARA TSUKASA; INUKI SHINSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  反応と合成の進歩シンポジウム講演要旨集, 30 Oct. 2009

  
• 多成分カップリング・連続環化反応によるピロロインドール誘導体及びジピロロピリジン誘導体の合成研究

  SUZUKI YAMATO; OTA YUSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  次世代を担う有機化学シンポジウム講演要旨集, 22 May 2009

  
• 銅触媒を用いた連続三成分結合形成反応による2‐(アミノメチル)インドール骨格およびインドール縮環型多環式骨格構築法の開発

  OTA YUSUKE; CHIBA KOSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2009

  
• 新規三環性ヘテロ芳香環構築反応の開発とキナーゼ阻害剤テンプレートへの応用

  SUZUKI YAMATO; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2009

  
• エンドキャップ抗HIV活性ペプチドSC35EKの合成

  KAJIWARA KAZUMI; TOKIWA REI; WATANABE KENTARO; OHNO HIROAKI; IZUMI KAZUKI; KODAMA EIICHI; MATSUOKA MASAO; OISHI SHIN'YA; FUJII NOBUTAKA

  日本薬学会年会要旨集, 05 Mar. 2009

  
• パラジウム触媒を用いたsp3C‐H活性化によるインドリンの合成

  WATABE TOSHIAKI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2009

  
• 多様なジペプチドイソスターの分岐的合成とGPR54アゴニストへの応用

  TOMITA KENJI; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 10 Nov. 2008

  
• ジペプチドイソスターの分岐型合成による酵素耐性GPR54アゴニストの創出

  TOMITA KENJI; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA

  反応と合成の進歩シンポジウム講演要旨集, 17 Oct. 2008

  
• 銅触媒‐マイクロ波照射を用いた連続三成分カップリング‐環化‐N‐アリール化反応によるインドール縮環型1,4‐ジアゼピン合成法の開発

  OTA YUSUKE; CHIBA HIROAKI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  反応と合成の進歩シンポジウム講演要旨集, 17 Oct. 2008

  
• パラジウム触媒によるアレン連続環化反応を利用したErgot Alkaloid骨格の一挙構築法開発と応用

  INUKI SHINSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  反応と合成の進歩シンポジウム講演要旨集, 17 Oct. 2008

  
• パラジウム触媒を用いたブロモエンアレンの連続的閉環反応による多環式複素環の一挙構築

  OKANO AKINORI; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA; MIZUTANI TSUYOSHI; TANAKA TETSUAKI

  反応と合成の進歩シンポジウム講演要旨集, 17 Oct. 2008

  
• Pd触媒によるアレン連続環化反応を利用したErgot Alkaloid骨格の一挙構築法開発と応用

  INUKI SHINSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  次世代を担う有機化学シンポジウム講演要旨集, 30 May 2008

  
• シスアミド等価体としてのZ型アルケンおよびE型フルオロアルケンジペプチドイソスターの合成と応用

  TOMITA KENJI; NARUMI TETSUO; NIIDA AYUMI; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA

  日本薬学会年会要旨集, 05 Mar. 2008

  
• ピラジンを母核とするCK2阻害剤の構造活性相関研究

  SUZUKI HIROKAZU; CLUZEAU JEROME; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA; HARA TAKASHI; HIRASAWA AKIRA; TSUJIMOTO GOZO

  日本薬学会年会要旨集, 05 Mar. 2008

  
• 求核的CF₃化反応による立体選択的トリフルオロメチルアルケン型ジペプチドイソスターの合成

  KOBAYASHI KAZUYA; NARUMI TETSUO; INOKUCHI ERIKO; TOMITA KENJI; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA

  日本薬学会年会要旨集, 05 Mar. 2008

  
• CXCR4受容体アンタゴニストの蛍光標識体の合成と応用

  MASUDA AKIRA; OISHI SHIN'YA; UEDA SATOSHI; EVANS BARRY; PEIPER STEPHEN C; HIRASAWA AKIRA; TSUJIMOTO GOZO; OHNO HIROAKI; FUJII NOBUTAKA

  日本薬学会年会要旨集, 05 Mar. 2008

  
• パラジウム触媒を用いたアレンの連続環化反応によるErgot alkaloid骨格の一挙構築

  INUKI SHINSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2008

  
• ヘリックス誘起モチーフを導入した抗HIVペプチドのデザインと合成

  WATANABE KENTARO; OISHI SHIN'YA; ITO SAORI; TANAKA MASANORI; NISHIKAWA HIROKI; WATABE TAKESHI; IZUMI KAZUKI; SAKAGAMI YASUKO; KODAMA EIICHI; MATSUOKA MASAO; OHNO HIROAKI; FUJII NOBUTAKA

  日本薬学会年会要旨集, 05 Mar. 2008

  
• Chemical Virologyを基盤とする新興・再興ウイルス侵入阻害剤の開発研究

  FUJII NOBUTAKA; OISHI SHIN'YA; NISHIKAWA HIROKI; WATANABE TSUYOSHI; OHNO HIROAKI; UJIIE MAKOTO; TAGUCHI FUMIHIRO; KODAMA EIICHI; MATSUOKA MASAO

  ケミカルバイオロジーシンポジウム発表要旨集 第4回 化学-生物融合領域創成の軌跡 理研シンポジウム 平成20年, 2008

  
• T‐20(Fuzeon)耐性HIV‐1変異株における6‐ヘリカルバンドル構造のX線構造解析

  渡部毅; 大石真也; 西川裕輝; 渡辺健太郎; 中野博明; 中津亨; 大野浩章; 加藤博章; 児玉栄一; 松岡雅雄; 藤井信孝

  日本化学会講演予稿集,88th,2,878, 2008

  
• シス型アミド結合等価体としてのZ型アルケンおよびE型フルオロアルケンジペプチドイソスターの合成と応用

  TOMITA KENJI; NARUMI TETSUO; NIIDA AYUMI; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 09 Nov. 2007

  
• 新規非ペプチド性ケモカイン受容体CXCR4アンタゴニストの創製研究

  KATO MANABU; UEDA SATOSHI; INUKI SHINSUKE; OISHI SHIN'YA; OHNO HIROAKI; EVANS BARRY; WANG ZI-XUAN; PEIPER STEPHEN C; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 09 Nov. 2007

  
• 連続結合形成反応による縮環型芳香族化合物の一挙合成法の開発

  OHNO HIROAKI; OTA YUSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; IUCHI MUTSUMI; TANAKA TETSUAKI

  反応と合成の進歩シンポジウム講演要旨集, 20 Oct. 2007

  
• パラジウム触媒カルボニル化反応を用いたトリフルオロメチルアルケンジペプチドイソスターおよび類縁体の新規合成法の開発

  INOKUCHI ERIKO; NARUMI TETSUO; NIIDA AYUMU; TOMITA KENJI; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA

  反応と合成の進歩シンポジウム講演要旨集, 20 Oct. 2007

  
• Pd触媒を用いたタンデム型N‐アリール化―C‐H活性化によるカルバゾールの合成と反応機構の考察

  WATABE TOSHIAKI; UEDA SATOSHI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  次世代を担う有機化学シンポジウム講演要旨集, 25 May 2007

  
• (Z)‐トリフルオロメチルアルケン型ジペプチドイソスターの高立体選択的合成法

  INOKUCHI ERIKO; NARUMI TETSUO; NIIDA AYUMI; KOBAYASHI KAZUYA; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA

  日本薬学会年会要旨集, 05 Mar. 2007

  
• Pd触媒を用いたタンデム型N‐アリール化―C‐H活性化によるカルバゾールの合成と反応機構の考察

  WATABE TOSHIAKI; UEDA SATOSHI; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  日本薬学会年会要旨集, 05 Mar. 2007

  
• GPR54に対するフルオロベンゾイルペンタペプチドの構造親和性相関研究

  TOMITA KENJI; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA

  日本薬学会年会要旨集, 05 Mar. 2007

  
• EKコンセプトを利用した高活性HIV膜融合阻害剤の創製研究

  ITO SAORI; OISHI SHIN'YA; NISHIKAWA YUKI; TANAKA MASANORI; WATANABE KENTARO; IZUMI KAZUKI; KODAMA EIICHI; MATSUOKA MASAO; OHNO HIROAKI; FUJII NOBUTAKA

  日本薬学会年会要旨集, Mar. 2007

  
• Direct synthesis of 2-(aminomethyl)indoles through copper(I)-catalyzed domino three-component coupling and cyclization reactions (vol 46, pg 2295, 2007)

  H. Ohno; Y. Ohta; S. Oishi; N. Fujii

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007

  
• Development of a novel fusion inhibitor against t-20-resistant HIV-1

  S. Oishi; S. Ito; H. Nishikawa; M. Tanaka; H. Ohno; A. Otaka; K. Izumi; E. Kodama; M. Matsuoka; N. Fujii

  BIOPOLYMERS, 2007

  
• Synthesis and application of (Z)-alkene- and (E)-fluoroalkene-dipeptide isosteres as cis-amide equivalents

  K. Tomita; T. Narumi; A. Niida; S. Oishi; H. Ohno; N. Fujii

  BIOPOLYMERS, 2007

  
• シスアミド等価型アルケンジペプチドイソスターの合成と応用

  OISHI SHIN'YA; NIIDA AYUMI; NARUMI TETSUO; TOMITA KENJI; INOKUCHI ERIKO; OHNO HIROAKI; KITAURA KAZUO; FUJII NOBUTAKA; OTAKA AKIRA; INUI KEN'ICHI

  反応と合成の進歩シンポジウム講演要旨集, 20 Nov. 2006

  
• パラジウム触媒による炭素‐フッ素結合切断を伴うフルオロアルケン骨格の合成

  NARUMI TETSUO; TOMITA KENJI; INOKUCHI ERIKO; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA

  反応と合成の進歩シンポジウム講演要旨集, 20 Nov. 2006

  
• 銅触媒を用いた三成分カップリングによる2‐(アミノメチル)インドール骨格構築法の開発

  OTA YUSUKE; OISHI SHIN'YA; FUJII NOBUTAKA; OHNO HIROAKI

  反応と合成の進歩シンポジウム講演要旨集, 20 Nov. 2006

  
• 二核亜鉛錯体構造を有する新規ケモカインレセプターCXCR4アンタゴニストの創製

  OGAWA TEPPEI; TAMAMURA HIROKAZU; OJIDA AKIO; TSUTSUMI HIROSHI; NAKASHIMA HIDEKI; OISHI SHIN'YA; OHNO HIROAKI; HAMACHI ITARU; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 10 Nov. 2006

  
• EKコンセプトを利用した高活性HIV膜融合阻害剤の創製研究

  ITO SAORI; OISHI SHIN'YA; NISHIKAWA HIROKI; TANAKA MICHINORI; IZUMI KAZUKI; KODAMA EIICHI; MATSUOKA MASAO; OHNO HIROAKI; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 10 Nov. 2006

  
• Structure-activity relationship studies on GPR54 agonists

  TOMITA KENJI; OISHI SHIN'YA; OHNO HIROAKI; FUJII NOBUTAKA; AKAMATSU MIKI

  構造活性相関シンポジウム講演要旨集, 07 Nov. 2006

  
• 有機金属による炭素‐フッ素結合切断を伴うフルオロアルケン骨格の合成:多価官能基を有するフルオロアルケン型ジペプチドイソスターの高立体選択的合成への展開

  NARUMI TETSUO; TOMITA TAKETSUGU; NIIDA AYUMI; OISHI SHIN'YA; OTAKA AKIRA; OHNO HIROAKI; FUJII NOBUTAKA

  次世代を担う有機化学シンポジウム講演要旨集, 19 May 2006

  
• フルオロアルケンイソスターの高立体選択的合成法の開発と生理活性ペプチドへの応用

  NARUMI TETSUO; MIYATANI TOSHIJIRO; NIIDA AYUMI; TOMITA KENJI; OISHI SHIN'YA; OHNO HIROAKI; OTAKA AKIRA; FUJII NOBUTAKA

  日本薬学会年会要旨集, 06 Mar. 2006

  
• パラジウム触媒による炭素‐フッ素結合活性化を伴うフルオロアルケンイソスターの新規合成法の開発

  NARUMI TETSUO; NIIDA AYUMI; TOMITA KENJI; OISHI SHIN'YA; OTAKA AKIRA; OHNO HIROAKI; FUJII NOBUTAKA

  日本薬学会年会要旨集, 06 Mar. 2006

  
• ペンタペプチド性GPR54アゴニストのN末端領域における構造活性相関研究および定量的構造活性相関研究

  TOMITA KENJI; NIIDA AYUMI; HARADA TOSHIYUKI; OISHI SHIN'YA; OHNO HIROAKI; AKAMATSU MIKI; FUJII NOBUTAKA

  日本薬学会年会要旨集, 06 Mar. 2006

  
• 多価官能基を有するフルオロアルケン型ジペプチドイソスターの高立体選択的合成法の開発

  NARUMI TETSUO; NIIDA AYUMU; TOMITA KENJI; OISHI SHIN'YA; OHNO HIROAKI; OTAKA AKIRA; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 10 Nov. 2005

  
• 低分子GPR54作動剤の構造活性相関研究

  TOMITA KENJI; NIIDA AYUMU; OISHI SHIN'YA; OHNO HIROAKI; OTAKA AKIRA; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 10 Nov. 2005

  
• フッ化物を用いない有機ケイ素化合物のカップリング反応

  大野 浩章

  ファルマシア, 01 May 2002

  
• ジエチル亜鉛と触媒量のパラジウム(0)を用いたアレンの合成

  OHNO HIROAKI; MIYAMURA KUMIKO; TANAKA TETSUAKI; TODA AYAKO; OISHI SHIN'YA; FUJII NOBUTAKA; TAKEMOTO YOSHIJI; IBUKA TOSHIRO

  反応と合成の進歩シンポジウム講演要旨集, 27 Oct. 2000

  

Presentations

• Gold-Catalyzed Cascade Cyclization for Fused Ring Construction

  Hiroaki Ohno

  The 8th Japanese-Sino Symposium on Organic Chemistry for Young Scientists, 19 Sep. 2019, Invited

  
• Gold-Catalyzed C-C bond Formation and Its Application to Alkaloid Synthesis

  Hiroaki Ohno

  Technische Universität Wien Special Lecture, 06 Aug. 2019, Invited

  
• Gold-Catalyzed Cascade Cyclization Reactions via C-H Bond Cleavage

  Hiroaki Ohno

  The 47th Naito Conference, 03 Jul. 2019

  
• Gold-Catalyzed C-C bond Formation and Its Application to Alkaloid Synthesis

  OHNO Hiroaki

  1st NCTU Conference on Advanced Organic Synthesis, 17 Dec. 2018, Invited

  
• 天然物骨格一挙構築法の開発と応用

  大野 浩章

  京大テックフォーラム, 30 Oct. 2018, Invited

  
• 金触媒を用いた複素環骨格の構築とアルカロイドの全合成

  大野 浩章

  第53回天然物化学談話会, 04 Jul. 2018, Invited

  
• ⾦触媒を⽤いたアルカロイド型⾻格の構築と応⽤

  大野 浩章

  千葉大学大学院 薬学研究院 特別講義, 08 Jun. 2018, Invited

  
• ⾦触媒を⽤いたアルカロイド型⾻格の構築と応⽤

  大野 浩章

  岡山大学医歯薬学総合研究科 特別講演会, 29 Sep. 2017, Invited

  
• ⾦触媒を⽤いた複素環⾻格構築法の開発と応⽤

  大野 浩章

  中外製薬 講演会, 13 Sep. 2017, Invited

  
• 金触媒によるアルカロイド型骨格の構築と全合成研究

  大野 浩章

  第37回有機合成若手セミナー, 09 Aug. 2017, Invited

  
• Direct Construction of Fused Nitrogen Heterocycles by Gold-Catalyzed Cascade Cyclizations

  OHNO Hiroaki

  Nordic/Kyoto OMCOS 2017, 24 Jun. 2017, Invited

  
• 金触媒によるアルキンの活性化を基盤とした骨格構築反応の開発と応用

  大野 浩章

  明治薬科大学 特別講義, 19 Dec. 2016, Invited

  
• 金触媒を用いた反応の開発と応用

  大野 浩章

  塩野義製薬（株） 創薬化学研究所セミナー, 03 Oct. 2016, Invited

  
• 多重結合の連続活性化を用いた骨格構築反応の開発と応用

  大野 浩章

  近畿大学薬学研究科 大学院特別講義, 23 Apr. 2016, Invited

  
• Efficient Construction of Heterocyclic Scaffolds and Its Application

  OHNO Hiroaki

  AGORA Bayer Meeting 2016, 15 Apr. 2016, Invited

  
• Gold-Catalyzed Cascade Cyclizations of Alkynes for Construction of Nitrogen Heterocycles

  OHNO Hiroaki

  Pacifichem, 15 Dec. 2015, Invited

  
• 金触媒によるアルキンの活性化を用いた骨格構築反応の開発と応用

  大野 浩章

  名城大学特別講演会, 04 Dec. 2015, Invited

  
• アルキンの活性化を基盤とする複素環骨格構築反応の開発と応用

  大野 浩章

  京大有機金属化学若手勉強会, 31 Oct. 2015, Invited

  
• アルキンの活性化を基盤とする連続反応の開発と応用

  大野 浩章

  日本薬学会東海支部特別講演会, 29 May 2015, Invited

  
• π結合の活性化を基盤とする連続反応の開発と応用

  大野 浩章

  東京医科歯科大学 生材研セミナー, 26 Jan. 2015, Invited

  
• Gold-Catalyzed Annulations and Their Medicinal Applications

  OHNO Hiroaki

  DPhG Annual Meeting 2014, 25 Sep. 2014, Invited

  
• アレンやアルキンを合成素子とする連続反応の開発と応用

  大野 浩章

  金沢大学 医歯薬保健研究域薬学系 講演会, 13 Jun. 2014, Invited

  
• 金触媒を用いた骨格構築反応の開発と生物活性化合物合成への応用

  大野 浩章

  京都府立大学 鴨叡会・生命分子化学科セミナー, 17 Dec. 2013, Invited

  
• 金触媒を用いた骨格構築反応の開発と生物活性化合物合成への応用

  大野 浩章

  立命館大学 創薬基盤科学若手セミナー, 09 Dec. 2013, Invited

  
• 付加反応を用いて中心骨格を構築する天然物合成

  大野 浩章

  第12回化学系薬学若手研究者セミナー, 24 Aug. 2013, Invited

  
• 高い原子効率を有する遷移金属触媒反応を用いた天然物の合成研究

  天然物ケミカルバイオロジー：分子標的と活性制御地区シンポジウム, 16 Mar. 2013, 新学術領域「天然物ケミカルバイオロジー：分子標的と活性制御」, Invited

  
• Gold-Catalyzed Reactions for Construction of Heterocycles

  OHNO Hiroaki

  Dortmund University Special Lecture, 06 Mar. 2013, Invited

  
• Gold-Catalyzed Reactions for Construction of Heterocycles

  OHNO Hiroaki

  Heidelberg University Special Lecture, 04 Mar. 2013, Invited

  
• 触媒的連続結合形成反応による縮環型複素環骨格の一挙構築と天然物合成への応用

  6th Organic Syntheses Lectureship, 22 Feb. 2011, 東京大学薬学研究科, Invited

  
• 触媒的連続結合形成反応による複素環骨格構築法の開発研究

  京都大学グローバルCOE プログラム有機若手ワークショップ, 14 Sep. 2010, 京都大学グローバルCOE プログラム, Invited

  
• 触媒的連続結合形成反応の開発とErgotアルカロイド全合成への応用

  第43回天然物化学談話会, 10 Jul. 2008, 天然物化学談話会, Invited

  
• アレンを合成素子とする触媒的連続結合形成反応の開発

  有機合成協会関西支部賞受賞講演, 08 Nov. 2006, 有機合成協会関西支部, Invited

  
• From amino acids to peptide isosteres and heterocycles: implications to vinylaziridines and amino allene chemistry

  11th Akabori conference, 11 Sep. 2006, Akabori Society

  
• アレン系化合物の新しい反応性に基づく有用反応の開発と連続環化反応への展開

  日本薬学会第124年会（奨励賞受賞講演）, 30 Mar. 2005, 日本薬学会, Invited

  
• アレンとパラジウム触媒の新しい反応性を利用した複素環合成

  日本薬学会第124年会ミニシンポジウム「有機合成化学の若い力」, 29 Mar. 2004, 日本薬学会, Invited

  
• パラジウム(0)を触媒としたアミノアレンの環化反応

  第51回日本薬学会近畿支部総会・大会（受賞講演）, 27 Oct. 2001, 日本薬学会近畿支部, Invited

  

Books and Other Publications

• Intramolecular C−X Bond Formation between C=X or X−H and Alkynes (in Transition-Metal-Mediated Aromatic Ring Construction)

  Hiroaki Ohno

  Wiley, 2013, Not refereed

  
• Synthesis by Substitution (in Science of Synthesis)

  Hiroaki Ohno; Kiyoshi Tomioka

  Thieme, 2007, Not refereed

  
• Vinylaziridines in Organic Synthesis (in Aziridines and Epoxides in Organic Synthesis)

  Hiroaki Ohno

  Wiley-VCH, 2005, Not refereed

  
• Enantioselective Synthesis of Allenes (in Modern Allene Chemistry)

  Hiroaki Ohno; Yasuo Nagaoka; Kiyoshi Tomioka

  Wiley-VCH, 2004, Not refereed

  

Industrial Property Rights

• 特開2012-250973, 特願2012-050334, ピリミドベンゾチアジン−6−イミン誘導体またはその塩を含有するウイルス感染症の治療および/または予防のための薬剤

  前田 英樹; 加藤 貴之; 松岡 雅雄; 志村 和也; 藤井 信孝; 大野 浩章; 大石 真也; 水原 司

  
• WO2012-121168, JP2012055451, キナーゼ阻害剤

  辻本 豪三; 平澤 明; 村田 克美; 藤井 信孝; 大野 浩章; 大石 真也; 鈴木 大和; ゾンイェ ホウ; 仲西 功; 木下 誉富; 高倉 喜信; 西川 元也

  
• WO2012-118124, JP2012055099, 新規ケモカイン受容体拮抗剤

  藤井 信孝; 大野 浩章; 大石 真也; 井ノ口 恵利子; 久保 達彦; 松岡 雅雄; 志村 和也

  
• 特開2012-051804, 特願2008-331963, Eg5阻害剤

  藤井 信孝; 大野 浩章; 大石 真也; 渡部 敏明; 浅井 章良; 澤田 潤一

  

Awards

• Jan. 2001

  The Pharmaceutical Society of Japan, Kinki Branch Award for Encouragement of Research
• Mar. 2005

  The Pharmaceutical Society of Japan, Award for Young Scientists
• Dec. 2005

  The Society of Synthetic Organic Chemistry, Japan, Meiji Seika Award in Synthetic Organic Chemistry, Japan
• Nov. 2006

  Kansai Branch, The Society of Synthetic Organic Chemistry, Japan, Kansai Branch Award
• Nov. 2013

  Banyu Life Science Foundation, Banyu Chemist Award
• Feb. 2014

  Thieme, Thieme Chemistry Journals Award
• 24 Oct. 2014

  Faculty of Pharmaceutical Sciences, Kyoto University, Best Teacher Award

External funds: Kakenhi

• Alkaloid Synthesis and Its Middle Molecular Strategy Based on Reaction Integration

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Kyoto University

  大野 浩章

  From 01 Apr. 2018, To 31 Mar. 2020, Project Closed

  アルカロイド;金触媒;連続反応;反応集積化;中分子

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-18H04408/
• Synthetic and medicinal studies on bioactive indole alkaloids based on direct construction of polycyclic ring systems

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Ohno Hiroaki

  From 01 Apr. 2017, To 31 Mar. 2021, Project Closed

  天然物合成;連続反応;アルカロイド;金触媒;創薬;多環式芳香族化合物;インドール;有機化学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H03971/
• Precise activation based on transition state control using neighboring effect and its medicinal application

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Hiroaki Ohno

  From 10 Jul. 2015, To 31 Mar. 2019, Project Closed

  近接効果;多環式骨格;連続反応;金触媒;アルカロイド;骨格構築;マクロ環化;創薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15KT0061/
• Development of Novel Drug Discovery Technologies for Target Proteins with Elusive Molecular Basis

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Nobutaka Fujii

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  ペプチド;複素環;GPCR;ケモカイン;創薬テンプレート;合理的分子設計;キナーゼ;環状ペプチド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04654/
• Develoment of a screening platform using mirror-image proteins and their application to drug discovery

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Oishi Shinya

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  天然物;ペプチド;キラル化合物;スクリーニング;医薬品探索;SH2ドメイン;カスパーゼ;BIRドメイン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04653/
• Innovative Molecular Transformations Based on Consecutive pai-Activation and Their Medicinal Applications

  Grant-in-Aid for Young Scientists (A)

  Kyoto University

  Ohno Hiroaki

  From 01 Apr. 2012, To 31 Mar. 2017, Project Closed

  多重結合;連続反応;全合成;化合物ライブラリー;アルカロイド;薬らしさ;天然物;金触媒;キノカルシン;ストリクタミン;インドール

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24689001/
• Development and application of a novel screening technolgy toward effective uses of chemical library

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Nobutaka FUJII

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  天然物;化合物ライブラリー;スクリーニング;アッセイ;生物活性化合物;鏡像体;天然有機化合物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659046/
• 原子移動型反応の高度集積化による多環式芳香族化合物の合成と創薬展開

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Science and Engineering

  Kyoto University

  大野 浩章

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  反応集積化;原子効率;多環式芳香環;アルカロイド;遷移金属触媒;アセトゲニン;キナーゼ阻害剤

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-24106720/
• Practical medicinal chemistry on the basis of protein chemistry, computational science and synthetic technologies for a variety of heterocycles

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Nobutaka FUJII

  From 01 Apr. 2011, To 31 Mar. 2015, Project Closed

  CXCR4;CXCR7;ケモカイン;CK2;キナーゼ;KSP;キネシン;複素環;CXCR4ケモカイン受容体;CXCR7ケモカイン受容体;ホモロジーモデル;プロテインキナーゼCK2;スフィンゴシンキナーゼ;jaspine B;FC131;キネシンモータータンパク;分子設計;ドラッグライク;ケモカイン受容体;複素環骨格構築反応

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390025/
• Divergent syntheses of biologically active compounds based on catalytic cascade cyclization reactions

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Hiroaki OHNO

  From 01 Apr. 2010, To 31 Mar. 2012, Project Closed

  有機化学;Ergotアルカロイド;連続反応;スフィンゴ脂質;構造活性相関研究;インドール;テトラヒドロフラン;抗腫瘍活性;全合成研究

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22590005/
• 触媒的多成分反応・高原子効率反応の高度集積化と創薬展開

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Science and Engineering

  Kyoto University

  大野 浩章

  From 01 Apr. 2010, To 31 Mar. 2012, Project Closed

  反応集積化;インドールアルカロイド;カルバゾール;スフィンゴ脂質;パラジウム触媒;金触媒;アレン;ポリイン

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22106521/
• GPCR周辺の細胞外環境解明のためのケミカルプローブの創出と応用

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  大石 真也;藤井 信孝

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  CXCR4;GPR54;ケモカイン;癌;構造活性相関

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20057011/
• 多重標的創薬概念に基づくがん化学療法の新機軸

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  大石 真也;藤井 信孝

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  CXCR4;薬剤耐性;ケモカイン;癌;構造活性相関

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20015021/
• Development of highly atom-economical synthetic methods based on catalytic cascade reactions

  Grant-in-Aid for Young Scientists (A)

  Kyoto University

  Hiroaki OHNO

  From 01 Apr. 2007, To 31 Mar. 2010, Project Closed

  有機化学;多成分反応;連続反応;銅;パラジウム;金;インドール;イソキノリン;アミジン;β-カルボリン;Ergotアルカロイド;リゼルグ酸;C-H活性化;カルバゾール;アルケンイソスター

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19689001/
• ドラッグ指向性化合物バンクの構築と創薬展開

  Grant-in-Aid for Exploratory Research

  Kyoto University

  藤井 信孝

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  化合物バンク;ドラッグ指向性;創薬テンプレート;ケミカルバイオロジー;多成分反応;イソキノリン;キノリン;インドリン;インドール;コンビナトリアル合成;固相反応

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18659027/
• 癌転移・骨髄依存薬物耐性の動的超分子機構解明のケミカルプローブ創出と創薬展開

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  藤井 信孝

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  構造活性相関;GPR54;ケモカイン;癌;CXCR4;SDF-1;Eg5;薬剤耐性;Kisspeptin

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18015027/
• 複雑な構造を有する生物活性複素環の一挙合成法の開発と環境調和型連続反応への展開

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  大野 浩章

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  複素環;連続反応;多成分反応;原子効率;環化付加反応;インドール;ソクロブタン;銅触媒;アレン;パラジウム;スルファミド;CH活性化;ベンゾイソインドール

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17790013/
• 生物活性を有する含窒素複素環の自在な合成を指向した新規環形成反応の開発研究

  Grant-in-Aid for Young Scientists (B)

  Osaka University

  大野 浩章

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  パラジウム触媒;複素環;タンデム反応;ヘテロ中員環;シクロプロパン;パラジウムカルベン;スルファミド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15790010/
• パラジウム触媒を用いた新規反応活性種の創出と合成反応への利用

  Grant-in-Aid for Exploratory Research

  Osaka University

  田中 徹明

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  パラジウム触媒;パラジウムカルベン;シクロプロパン;タンデム反応;スルフェン酸亜鉛;ビニルスルホキシド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15659003/
• Synthesis of Biologically Active Compounds Using Potential Utility of Transition Metals

  Grant-in-Aid for Scientific Research (C)

  Osaka University

  Tetsuaki TANAKA

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  ヨウ化サマリウム;スピロ閉環反応;ケチルラジカル;スルフィニルアニオン;パラジウム触媒;ジエチル亜鉛;アミノアレン;π-アリルパラジウム錯体;SmI2;HMPA;アレン, Samarium Iodide;Spirocyclization;Ketyl Radical;Sulfinyl Anion;Palladium Catalyst;Diethylzinc;Amino Allenes;π-Allyl Palladium

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13672212/
• 高活性な降圧剤及びプロテアーゼ阻害剤の開発を指向したアミノアレンの合成研究

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Osaka University

  大野 浩章

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  アミノアレン;有機銅試薬;パラジウム;ジエチル亜鉛;アレン;軸不斉;立体選択的合成;触媒反応

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12771353/
• Synthesis of Novel Bowl-Shaped Highly pi-Conjugated Molecules Based on the Original Vinylcation Formation

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 33:Organic chemistry and related fields

  Kyoto University

  Hiroaki Ohno

  From 30 Jun. 2022, To 31 Mar. 2024, Project Closed

  金触媒;ビニルカチオン;お椀型分子;π共役系;連続反応;フェナントレン;ジベンゾフルオレン;ベンゾフルオランテン;インドール;π共役分子;ひずみ分子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19028/
• Natural product syntheses based on cascade cyclization and their applications to middle-molecule drug modalities

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related

  Kyoto University

  大野 浩章

  From 01 Apr. 2023, To 31 Mar. 2027, Granted

  アルカロイド;連続反応;金触媒;中分子;ケミカルスペース

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02603/
• Natural product syntheses based on cascade cyclization and their applications to middle-molecule drug modalities

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47010:Pharmaceutical chemistry and drug development sciences-related

  Kyoto University

  大野 浩章

  From 01 Apr. 2023, To 31 Mar. 2027, Granted

  アルカロイド;連続反応;金触媒;中分子;ケミカルスペース

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27294/
• フィロウイルスの増殖機構の分子構造基盤の解明と制御法の開発

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 49:Pathology, infection/immunology, and related fields

  Kyoto University

  野田 岳志

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  エボラウイルス;ヌクレオカプシド;抗ウイルス薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24H00609/

Education

Teaching subject(s)

• From 01 Apr. 2025, To 31 Mar. 2026

  Research in Practical Drug Discovery Science

  3214, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Medicinal Frontier Science Research B

  8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Medicinal Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Research in Medicinal Frontier Sciences

  3215, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Medicinal Frontier Science Research C

  8408, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2025, To 31 Mar. 2026

  Outline of Physiological Chemistry

  X101, Fall, Graduate School of Agriculture, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Organic Chemistry II

  N348, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Outline of Physiological Chemistry

  M212, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Practice in Practical Drug Discovery Science

  4212, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Organic Chemistry for Drug Discovery B

  8204, Fall, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Organic Chemistry for Drug Discovery A

  8203, Fall, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Practice in Medicinal Frontier Sciences

  4213, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Medicinal Frontier Science A

  8209, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Proposal Writing Practice B

  8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  International Skills Practice A

  8303, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutical Laboratory Coaching Practice B

  8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Industry-academia Collaborative Internship B

  8306, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Industry-academia Collaborative Internship A

  8305, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  International Skills Practice B

  8304, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Training(Biopharmaceutical Chemistry)

  D168, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Training(Bioorganic Medicinal Chemistry)

  D171, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2024, To 31 Mar. 2025

  Practical Drug Discovery Science Seminar

  2315, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Basic Organic Chemistry II

  1210, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Laboratory Techniques in Organic Chemistry

  1205, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Clinical Pharmacy

  6001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar in Medicinal Frontier Sciences

  2316, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Organic Chemistry for Drug Discovery

  1026, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Critical Reading of Scientific Papers B

  8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Methods in Systems Biology & Drug Discovery

  7007, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Methods in Systems Biology & Drug Discovery

  7007, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Pharmaceutical Sciences I

  6005, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Organic Chemistry for Drug Discovery

  8102, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Practical Drug Discovery Science

  3214, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Systems Biology & Drug Discovery

  7005, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Systems Biology & Drug Discovery

  7005, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Medicinal Frontier Sciences

  3215, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Frontier Science Research C

  8408, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Frontier Science Research B

  8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Outline of Physiological Chemistry

  X101, Fall, Graduate School of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Outline of Physiological Chemistry

  M212, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Organic Chemistry II

  N348, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Practical Drug Discovery Science

  4212, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Organic Chemistry for Drug Discovery A

  8203, Fall, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Medicinal Frontier Sciences

  4213, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory Coaching Practice B

  8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Industry-academia Collaborative Internship A

  8305, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  International Skills Practice A

  8303, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Proposal Writing Practice B

  8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Biopharmaceutical Chemistry)

  D168, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Chemogenomics)

  D156, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Chemogenomics)

  B817, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Bioorganic Medicinal Chemistry)

  D171, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Chemogenomics)

  E816, Year-long, Faculty of Pharmaceutical Sciences, 14
• From 01 Apr. 2023, To 31 Mar. 2024

  Medicinal Frontier Science Research B

  8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Medicinal Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Systems Biology & Drug Discovery

  7005, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Medicinal Frontier Sciences

  3215, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Practical Drug Discovery Science

  3214, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Systems Biology & Drug Discovery

  7005, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Systems Biology & Drug Dicovery

  5301, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Skill Development for Lead Discovery

  5102, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Chemogenomics)

  8156, Year-long, Faculty of Pharmaceutical Sciences, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Biopharmaceutical Chemistry)

  8165, Year-long, Faculty of Pharmaceutical Sciences, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Outline of Physiological Chemistry

  X101, Fall, Graduate School of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Basic Organic Chemistry I

  1209, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Organic Chemistry

  1205, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Organic Chemistry for Drug Discovery

  1026, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Methods in Systems Biology & Drug Discovery

  5501, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar in Medicinal Frontier Sciences

  2316, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Practical Drug Discovery Science Seminar

  2315, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Clinical Pharmacy

  6001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Critical Reading of Scientific Papers B

  8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Methods in Systems Biology & Drug Discovery

  7007, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Pharmaceutical Sciences I

  6005, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Organic Chemistry for Drug Discovery

  8102, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Methods in Systems Biology & Drug Discovery

  7007, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Bioorganic Medicinal Chemistry)

  D171, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Medical Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Practice in Medicinal Frontier Sciences

  4213, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Chemogenomics)

  8156, Year-long, Faculty of Pharmaceutical Sciences, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Biopharmaceutical Chemistry)

  8165, Year-long, Faculty of Pharmaceutical Sciences, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Methods in Systems Biology & Drug Discovery

  7007, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Laboratory Techniques in Biological Chemistry

  1207, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Organic Chemistry for Drug Discovery

  1026, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Skill Development for Lead Discovery

  5102, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Organic Chemistry II

  N348, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Basic Organic Chemistry II

  1210, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar in Medicinal Frontier Sciences

  2316, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Practical Drug Discovery Science Seminar

  2315, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Chemogenomics)

  D156, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Systems Biology & Drug Discovery

  7005, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Medicinal Frontier Sciences

  3215, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Organic Chemistry for Drug Discovery

  8102, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Biopharmaceutical Chemistry)

  D168, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Pharmaceutical Sciences I

  6005, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Systems Biology & Drug Dicovery

  5301, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Organic Chemistry for Drug Discovery B

  8204, Fall, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Practical Drug Discovery Science

  3214, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Chemogenomics)

  B817, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Methods in Systems Biology & Drug Discovery

  7007, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Practice in Practical Drug Discovery Science

  4212, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Outline of Physiological Chemistry

  X101, Fall, Graduate School of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Methods in Systems Biology & Drug Discovery

  5501, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Drug Discovery & Development II: Lead Discovery Technology

  1111, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Outline of Physiological Chemistry

  M212, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Systems Biology & Drug Discovery

  7005, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From Apr. 2011, To Mar. 2012

  有機化学Ｉ（化学結合論）

  Spring, 薬学部
• From Apr. 2011, To Mar. 2012

  特別実習(ケモゲノミクス・薬品有機製造学)

  Year-long, 薬学部
• From Apr. 2011, To Mar. 2012

  Basic Organic Chemistry A

  Spring, 全学共通科目
• From Apr. 2011, To Mar. 2012

  特別実習[ケモゲノミクス・薬品有機製造学

  Year-long, 薬学部
• From Apr. 2011, To Mar. 2012

  Drug Discovery & Development II:

  Fall, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Organic Chemistry of Pharmaceuticals

  Spring, 全学共通科目
• From Apr. 2011, To Mar. 2012

  Basic Laboratory Techniques in Organic Chemistry

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Basic Laboratory Techniques in Organic Chemistry

  Fall, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Introduction to Basic Organic Chemistry

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Advanced Basic Organic Chemistry I

  Fall, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Laboratory Practice in Basic Medicinal and Organic Chemistry

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Research in Basic Medicinal and Organic Chemistry

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Seminar in Basic Medicinal and Organic Chemistry

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Advanced Methods in Systems

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Advanced Methods in Systems

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Research in Systems

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Research in Systems

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  薬学専門実習II

  Spring, 薬学部
• From Apr. 2011, To Mar. 2012

  薬学専門実習２

  Spring, 薬学部
• From Apr. 2012, To Mar. 2013

  Drug Discovery & Development II: Lead Discovery Technology

  Fall, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  doctoral program

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  doctoral program

  Fall, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Basic Laboratory Techniques in Organic Chemistry

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Basic Laboratory Techniques in Organic Chemistry

  Fall, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Introduction to Basic Organic Chemistry

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Advanced Basic Organic Chemistry II

  Fall, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Laboratory Practice in Basic Medicinal and Organic Chemistry

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Research in Basic Medicinal and Organic Chemistry

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Seminar in Basic Medicinal and Organic Chemistry

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Basic Organic Chemistry A

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Organic Chemistry I(Bonding in Organic Chemistry)

  Spring, 薬学部
• From Apr. 2012, To Mar. 2013

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2012, To Mar. 2013

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2012, To Mar. 2013

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Pharmaceutical Laboratory II:Organic Chemistry

  Spring, 薬学部
• From Apr. 2012, To Mar. 2013

  Pharmaceutical Laboratory 2 : Organic Chemistry

  Spring, 薬学部
• From Apr. 2013, To Mar. 2014

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2013, To Mar. 2014

  Pharmaceutical Laboratory 2 : Organic Chemistry

  Spring, 薬学部
• From Apr. 2013, To Mar. 2014

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2013, To Mar. 2014

  Introduction to Drug Discovery Sciences

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  doctoral program

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  doctoral program

  Fall, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Basic Organic Chemistry B

  Fall, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Organic Chemistry of Pharmaceuticals

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2014, To Mar. 2015

  Pharmaceutical Laboratory 2 : Organic Chemistry

  Spring, 薬学部
• From Apr. 2014, To Mar. 2015

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2014, To Mar. 2015

  Introduction to Drug Discovery Sciences

  Spring, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Drug Discovery & Development II: Lead Discovery Technology

  Fall, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Basic Organic Chemistry B

  Fall, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Organic Chemistry of Pharmaceuticals

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Organic Chemistry of Pharmaceuticals

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Introduction to Drug Discovery Sciences

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Basic Organic Chemistry II

  Fall, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2015, To Mar. 2016

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2015, To Mar. 2016

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Pharmaceutical Laboratory 2 : Organic Chemistry

  Spring, 薬学部
• From Apr. 2016, To Mar. 2017

  Drug Discovery & Development II: Lead Discovery Technology

  Fall, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Introduction to Drug Discovery Sciences

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Basic Organic Chemistry II

  Fall, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2016, To Mar. 2017

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2016, To Mar. 2017

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Introduction to Organic Chemistry for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Organic Chemistry II

  Fall, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2017, To Mar. 2018

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2017, To Mar. 2018

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Drug Discovery & Development II: Lead Discovery Technology

  Fall, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Introduction to Organic Chemistry for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Basic Organic Chemistry II

  Fall, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Organic Chemistry II

  Fall, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Outline of Physiological Chemistry

  Fall, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Introduction to Clinical Pharmacy

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Introduction to Organic Chemistry for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Skill Development for Lead Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Organic Chemistry II

  Fall, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Advanced Methods in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Methods in Systems Biology & Drug Discovery

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Dicovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Dicovery

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Discovery

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Introduction to Clinical Pharmacy

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Drug Discovery & Development II: Lead Discovery Technology

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Introduction to Organic Chemistry for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Skill Development for Lead Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Basic Organic Chemistry II

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Organic Chemistry II

  Fall, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Research Training(Biopharmaceutical Chemistry)

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Methods in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Methods in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Methods in Systems Biology & Drug Discovery

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Methods in Systems Biology & Drug Discovery

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Dicovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Dicovery

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Discovery

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Introduction to Clinical Pharmacy

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Introduction to Organic Chemistry for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Skill Development for Lead Discovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Organic Chemistry II

  Fall, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Laboratory Practice in Practical Drug Discovery Science

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Practical Drug Discovery Science

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Practical Drug Discovery Science Seminar

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research Training(Biopharmaceutical Chemistry)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Research Training(Biopharmaceutical Chemistry)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Research Training(Chemogenomics)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Methods in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科