Basic Information

Affiliated programs (koza)

• Graduate School of Pharmaceutical Sciences, 薬科学専攻 生体機能化学講座, 助教

Faculty

• 薬学部

Professional Memberships

• From 2019, To Present

  The Membrane Society of Japan
• From 2018, To Present

  Division of Biofunctional Chemistry, The chemical Society of Japan
• From 2017, To Present

  THE BIOPHYSICAL SOCIETY OF JAPAN
• From 2016, To Present

  The Japanese Peptide Society
• From 2011, To Present

  THE PHARMACEUTICAL SOCIETY OF JAPAN

Academic Degree

• 修士（薬学）(京都大学)
• 博士（薬学）(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院薬学研究科修士課程創薬科学専攻, 修了
• 京都大学, 大学院薬学研究科博士後期課程創薬科学専攻, 修了

Research History

• From Apr. 2021, To Present

  Kyoto University, Graduate School of Pharmaceutical Sciences, Assistant Professor
• From Apr. 2016, To Mar. 2021

  Kyoto University, Institute for Chemical Research, Assistant Professor
• From Oct. 2015, To Mar. 2016

  Kyoto University, Institute for Integrated Cell-Material Sciences (iCeMS), Postdoctoral fellow
• From Jul. 2015, To Sep. 2015

  Kyoto University, Graduate School of Pharmaceutical Sciences, Postdoctoral fellow
• From Apr. 2014, To Jun. 2015

  Kyoto University, Institute for Virus Research, Limited-term Assistant Professor

Profile

• Profile

  現在の研究課題
  1. 曲率認識ペプチドを担体とした細胞外小胞の新規回収法の開発
  2. 細胞外小胞に由来するアジュバント活性物質の探索
  3. 新規可溶化剤を用いた膜タンパク質の構造解析研究

ID,URL

• ORCID ID

  0000-0003-1927-2922

• J-Global ID

  201401004373240099

• Researcher number

  70732874

• External link

  https://www.pharm.kyoto-u.ac.jp/yakkai/

researchmap URL

• https://researchmap.jp/7000009602

Research

Research Interests

• Extracellular vesicles
• membrane curvature
• drug delivery
• membrane proteins
• fluorescence imaging
• lipid raft
• lipid packing
• peptide

Research Areas

• Life sciences, Pharmaceuticals - chemistry and drug development, Chemical Biology

Papers

• Synthesis and Properties of V-Shaped Xanthene Dyes with Tunable and Predictable Absorption and Emission Wavelengths

  Akari Yamagami; Kotaro Kiyotaki; Sae Wakabayashi; Naoki Egami; Kenichi Kawano; Shiroh Futaki; Ayumi Imayoshi; Kazunori Tsubaki

  The Journal of Organic Chemistry, 12 Jan. 2022, Peer-reviewed

  
• Design of the N-terminus Substituted Curvature-sensing Peptides that Exhibit Highly Sensitive Detection Ability of Bacterial Extracellular Vesicles

  Kenichi Kawano; Fumiaki Yokoyama; Kouhei Kamasaka; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara; Shiroh Futaki

  Chemical and Pharmaceutical Bulletin, 01 Nov. 2021, Peer-reviewed, Lead author, Corresponding author

  
• 細胞外膜小胞の高感度検出を基軸とした曲率認識ペプチドの創製研究

  Kenichi Kawano

  Peptide Newsletter Japan, 30 Jul. 2021, Peer-reviewed, Invited, Lead author, Last author, Corresponding author

  
• Influence of the Dabcyl group on the cellular uptake of cationic peptides: short oligoarginines as efficient cell-penetrating peptides

  Ildikó Szabó; Françoise Illien; Levente E. Dókus; Mo’ath Yousef; Zsuzsa Baranyai; Szilvia Bősze; Shoko Ise; Kenichi Kawano; Sandrine Sagan; Shiroh Futaki; Ferenc Hudecz; Zoltán Bánóczi

  Amino Acids, 25 May 2021, Peer-reviewed

  
• Membrane anchoring of a curvature-inducing peptide, EpN18, promotes membrane translocation of octaarginine

  Kakeru Kuroki; Takayuki Sakai; Toshihiro Masuda; Kenichi Kawano; Shiroh Futaki

  Bioorganic & Medicinal Chemistry Letters, 10 May 2021, Peer-reviewed

  
• Metal complex lipids for fluid–fluid phase separation in co-assembled phospholipid membranes

  Ryo Ohtani; Yuka Anegawa; Hikaru Watanabe; Yutaro Tajima; Masanao Kinoshita; Nobuaki Matsumori; Kenichi Kawano; Saeko Yanaka; Koichi Kato; Masaaki Nakamura; Masaaki Ohba; Shinya Hayami

  Angewandte Chemie International Edition, 15 Mar. 2021, Peer-reviewed

  
• Development of a Microwave Resonator and Effects of Electric and Magnetic Fields on Cultured Cancer Cells

  Mamiko Asano; Jun-ichi Sugiyama; Kenichi Kawano; Shiroh Futaki

  Thermal Medicine, Mar. 2021, Peer-reviewed

  
• Development of a Simple and Rapid Method for In Situ Vesicle Detection in Cultured Media

  Kenichi Kawano; Fumiaki Yokoyama; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara; Shiroh Futaki

  Journal of Molecular Biology, 12 Sep. 2020, Peer-reviewed, Lead author, Corresponding author

  
• Pseudo‐membrane jackets: Two‐dimensional coordination polymers achieving visible phase separation in cell membrane

  Ryo Ohtani; Kenichi Kawano; Masanao Kinoshita; Saeko Yanaka; Hikaru Watanabe; Kenji Hirai; Shiroh Futaki; Nobuaki Matsumori; Hiroshi Uji-i; Masaaki Ohba; Koichi Kato; Shinya Hayami

  Angewandte Chemie International Edition, 30 Jun. 2020, Peer-reviewed, Lead author

  
• Optimizing charge switching in membrane lytic peptides for endosomal release of biomacromolecules

  Kentarou Sakamoto; Misao Akishiba; Takahiro Iwata; Kazuya Murata; Seiya Mizuno; Kenichi Kawano; Miki Imanishi; Fumihiro Sugiyama; Shiroh Futaki

  Angewandte Chemie International Edition, 18 Jun. 2020, Peer-reviewed

  
• Rational Design Principles of Attenuated Cationic Lytic Peptides for Intracellular Delivery of Biomacromolecules

  Naoki Tamemoto; Misao Akishiba; Kentarou Sakamoto; Kenichi Kawano; Hiroshi Noguchi; Shiroh Futaki

  Molecular Pharmaceutics, Apr. 2020, Peer-reviewed

  
• Enhancing the Activity of Membrane Remodeling Epsin-Peptide by Trimerization

  Wei-Yuan Hsu, Toshihiro Masuda, Sergii Afonin, Takayuki Sakai, Jan Vincent V Arafiles, Kenichi Kawano, Hisaaki Hirose, Miki Imanishi, Anne S Ulrich, Shiroh Futaki

  Bioorganic & Medicinal Chemistry Letters, Apr. 2020, Peer-reviewed

  
• Loosening of Lipid Packing by Cell Surface Recruitment of Amphiphilic Peptides by Coiled-coil Tethering

  Takayuki Sakai; Kenichi Kawano; Masatomo Iino; Toshihide Takeuchi; Miki Imanishi; Shiroh Futaki

  ChemBioChem, Aug. 2019, Peer-reviewed

  
• Development of a membrane curvature-sensing peptide based on a structure–activity correlation study.

  Kenichi Kawano; Masaya Ogushi; Toshihiro Masuda; Shiroh Futaki

  Chemical & Pharmaceutical Bulletin, Jul. 2019, Peer-reviewed, Lead author

  
• Dipicolylamine/Metal Complexes that Promote Direct Cell-Membrane Penetration of Octaarginine.

  Kawaguchi Y; Ise S; Azuma Y; Takeuchi T; Kawano K; Le TK; Ohkanda J; Futaki S

  Bioconjugate chemistry, Feb. 2019, Peer-reviewed

  
• Development of xanthene dyes containing arylacetylenes: The role of acetylene linker and substituents on the aryl group

  Ryo Hirata; Ayame Torii; Kenichi Kawano; Shiroh Futaki; Ayumi Imayoshi; Kazunori Tsubaki

  Tetrahedron, 05 Jul. 2018, Peer-reviewed

  
• Importance of Net Hydrophobicity in the Cellular Uptake of All-Hydrocarbon Stapled Peptides

  Koki Sakagami; Toshihiro Masuda; Kenichi Kawano; Shiroh Futaki

  Molecular Pharmaceutics, 05 Mar. 2018, Peer-reviewed

  
• Syntheses and properties of second-generation V-shaped xanthene dyes with piperidino groups

  Akari Yamagami; Kenichi Kawano; Shiroh Futaki; Kouji Kuramochi; Kazunori Tsubaki

  Tetrahedron, Dec. 2017, Peer-reviewed

  
• ペプチド科学を基盤技術に用いた膜タンパク質と生体膜の研究

  河野 健一

  Peptide Newsletter Japan, Nov. 2017, Peer-reviewed, Lead author, Last author, Corresponding author

  
• Stoichiometric analysis of oligomeric states of three class-A GPCRs, chemokine-CXCR4, dopamine-D2, and prostaglandin-EP1 receptors, on living cells

  Kenichi Kawano; Tetsuya Yagi; Nozomu Fukada; Yoshiaki Yano; Katsumi Matsuzaki

  Journal of Peptide Science, Jul. 2017, Peer-reviewed, Lead author

  
• Loosening of Lipid Packing Promotes Oligoarginine Entry into Cells

  Tomo Murayama; Toshihiro Masuda; Sergii Afonin; Kenichi Kawano; Tomoka Takatani-Nakase; Hiroki Ida; Yasufumi Takahashi; Takeshi Fukuma; Anne S. Ulrich; Shiroh Futaki

  Angewandte Chemie International Edition, Jun. 2017, Peer-reviewed

  
• A pH-dependent charge reversal peptide for cancer targeting

  Naoko Wakabayashi; Yoshiaki Yano; Kenichi Kawano; Katsumi Matsuzaki

  European Biophysical Journal, Mar. 2017, Peer-reviewed

  
• 

  The 3G Condiments, Garlic, Ginger, and Green Onion, Exhibit Synergistic Antibacterial effects

  望月 達人; 河野 健一; 矢野 義明; 松崎 勝巳

  ELCAS Journal, Mar. 2016

  
• Oligomerization-function relationship of EGFR on living cells detected by the coiled-coil labeling and FRET microscopy

  Hirotaka Yamashita; Yoshiaki Yano; Kenichi Kawano; Katsumi Matsuzaki

  Biochimica et Biophysica Acta - Biomembranes, 2015, Peer-reviewed

  
• 

  A Dimer Is the Minimal Proton-Conducting Unit of the Influenza A Virus M2 Channel

  Kenichi Kawano; Yoshiaki Yano; Katsumi Matsuzaki

  Journal of Molecular Biology, Jul. 2014, Peer-reviewed, Lead author

  
• A visualization tool for oligomerization and internalization of membrane proteins in living cells: Coiled-coil labeling method

  Yoshiaki Yano; Kenichi Kawano; Kaoru Omae; Yuki Takeda; Sayaka Matsuzaki; Katsumi Matsuzaki

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2014, Peer-reviewed

  
• Stoichiometric analysis of oligomerization of membrane proteins using coiled-coil labeling and in-cell spectroscopy

  Kenichi Kawano

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2014, Peer-reviewed, Lead author

  
• 

  Stoichiometric analysis of oligomerization of membrane proteins on living cells using coiled-coil labeling and spectral imaging

  Kenichi Kawano; Yoshiaki Yano; Kaoru Omae; Sayaka Matsuzaki; Katsumi Matsuzaki

  Analytical Chemistry, 19 Mar. 2013, Peer-reviewed, Lead author

  
• 

  Coiled-Coil Tag–Probe Labeling Methods for Live-Cell Imaging of Membrane Receptors

  Yoshiaki Yano; Kenichi Kawano; Kaoru Omae; Katsumi Matsuzaki

  Methods Enzymology, 2012, Peer-reviewed

  

Misc.

• ペプチドが切り拓く小胞研究の新世界 〜マーカー発現量に依存しない新たなエクソソーム検出法の開発〜

  河野健一

  月刊「化学」（Review of Chemistry in 2021）, 01 Apr. 2021, Peer-reviewed, Invited, Lead author, Last author, Corresponding author

  
• 中分子創薬研究のフロンティア －生体分子を標的とした機能性ペプチドの創製

  河野健一; 中瀬生彦

  薬事日報（第12432号）P.4, 19 Mar. 2021, Peer-reviewed, Invited, Lead author, Corresponding author

  
• 中分子創薬研究のフロンティア:~ 生体分子の反応集積場としての膜曲率の役割~

  河野健一; 中瀬生彦

  薬事日報（第12286号）P.7, 18 Mar. 2020, Peer-reviewed, Invited, Lead author, Corresponding author

  
• オクタアルギニンを介した細胞内タンパク質送達法の細胞質輸送効率を評価するためのMALDI-TOF型質量分析計を用いた分析法(A MALDI-TOF mass spectroscopy-based approach to evaluate the cytosolic translocation efficiency of octaarginine-mediated intracellular protein delivery)

  Arafiles Jan Vincent; 川口 祥正; Cherine Bechara; Erancoise Illien; 河野 健一; Fabienne Burlina; Sandrine Sagan; 二木 史朗

  日本薬学会年会要旨集, Mar. 2017

  
• オクタアルギニンと血清タンパク質の相互作用

  野村 佳世; 河野 健一; 川口 祥正; 桑田 啓子; 二木 史朗

  日本薬学会年会要旨集, Mar. 2017

  
• CELL PENETRATION OF DIPICOLYLAMINE-MODIFIED R8 FACILITATED BY METAL COMPLEX FORMATION

  S. Ise; Y. Kawaguchi; T. Takeuchi; K. Kawano; S. Futaki

  JOURNAL OF PEPTIDE SCIENCE, Sep. 2016

  
• The Amantadine-Resistant S31N Mutant of Influenza a Virus M2 Protein Stably Forms a Dimer on the Living Cells

  Kenichi Kawano; Yoshiaki Yano; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2014

  
• Dimer is a Minimal Functional Unit of Influenza a Virus M2 Channel on Living Cells

  Kenichi Kawano; Yoshiaki Yano; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2014

  
• Influenza A virus M2 protein forms a dimeric channel in biomembranes

  K. Kawano; Y. Yano; K. Matsuzaki

  EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Jul. 2013

  
• 1P297 Development of methods for labeling and oligomerization analysis of membrane proteins in live cells(27. Bioimaging,Poster)

  Yano Yoshiaki; Kawano Kenichi; Omae Kaoru; Mtsuzaki Sayaka; Matsuzaki Katsumi

  Seibutsu Butsuri, 2013

  
• Detection of Oligomerization of Membrane Proteins using Coiled-Coil Tag-Probe Labeling Method and In-Cell Fluorescence Spectroscopy

  Kenichi Kawano; Kaoru Omae; Sayaka Matsuzaki; Yoshiaki Yano; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2013

  
• Oligomeric States of Full Length Influenza a Virus M2 Proteins on Biological Membranes

  Ken-ichi Kawano; Sayaka Matsuzaki; Kaoru Oomae; Yoshiaki Yano; Katsumi Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2013

  

Presentations

• Highly sensitive detection of extracellular vesicles with N-terminus-substituted curvature-sensing peptides

  Kenichi Kawano; Yuki Kuzuma; Fumiaki Yokoyama; Kouhei Kamasaka; Takuya Ogawa; Jun Kawamoto; Tatsuo Kurihara; Shiroh Futaki; Katsumi Matsuzaki

  The 142 Annual Meeting of The Pharmaceutical Society of Japan, 26 Mar. 2022

  
• Search for genes related to bacterial extracellular membrane vesicle production by high-throughput screening using curvature-sensing peptide

  井上宙夢; 河野健一; 川本純; 小川拓哉; 栗原達夫

  The 2022 Annual Meetings of The Japanese Society for Bioscience, Biotechnology and Agrochemistry (JSBBA), 18 Mar. 2022

  
• A novel detection tool of extracellular membrane vesicles of bacterial cells in cultured medium using a curvature-sensing peptide

  Kenichi Kawano; Fumiaki Yokoyama; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara; Shiroh Futaki

  EMBO BMVs Workshop, 24 Nov. 2021

  
• 曲率認識ペプチドを用いたShewanella vesiculosa HM13の細胞外膜小胞生産関連遺伝子の探索

  井上宙夢; 河野健一; 川本 純; 小川 拓哉; 栗原 達夫

  極限環境生物学会2021年度（第22回）, 20 Nov. 2021

  
• 生細胞膜中で形成されるアミロイドβタンパク質線維の構造解析

  角友登; 河野健一; 矢野義明; 星野大; 松崎勝巳

  第42回生体膜と薬物の相互作用シンポジウム, 28 Oct. 2021

  
• DESIGN OF CURVATURE-SENSING PEPTIDES FOR HIGHLY SENSITIVE DETECTION OF BACTERIAL EXTRACELLULAR VESICLES

  Kenichi Kawano; Fumiaki Yokoyama; Kouhei Kamasaka; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara; Shiroh Futaki

  The 58th Japanese Peptide Symposium, 21 Oct. 2021

  
• DEVELOPMENT OF ANTIMICROBIAL PEPTIDE–ANTIBIOTIC CONJUGATES FOR IMPROVED ANTIMICROBIAL ACTIVITY

  Ruka Yamauchi; Kenichi Kawano; Daigo Kajiwara; Yousuke Yamaoka; Yoshiaki Yano; Kiyosei Takasu; Katsumi Matsuzaki

  The 58th Japanese Peptide Symposium, 20 Oct. 2021

  
• 抗菌活性の向上を目指した抗菌性ペプチド-抗生物質conjugatesの開発

  山内瑠花; 河野健一; 梶原大悟; 山岡庸介; 矢野義明; 高須清誠; 松崎勝巳

  第53回若手ペプチド夏の勉強会, 10 Aug. 2021

  
• 細胞外小胞の高感度検出に向けた曲率認識ペプチドの設計指針

  河野健一; 横山文秋; 釜阪紘平; 小川拓哉; 川本純; 栗原達夫; 二木史朗

  日本膜学会第43年会, 05 Jun. 2021

  
• 曲率認識ペプチドを用いた細胞外膜小胞の簡便な検出法の開発

  河野健一

  日本薬学会第141年会, 29 Mar. 2021, Invited

  
• 曲率認識ペプチドを用いた細菌の菌体外膜小胞のハイスループット検出法の開発

  河野 健一; 小川 拓哉

  京都大学化学研究所 第120回化学研究所研究発表会, 11 Dec. 2020

  
• CURVATURE-SENSING PEPTIDES TO DISTINGUISH BACTERIAL EXTRACELLULAR MEMBRANE VESICLES FROM CELLS IN CULTURED MEDIUM

  K. Kawano; F. Yokoyama; J. Kawamoto; T. Ogawa; T. Kurihara; S. Futaki

  The 57th Japanese Peptide Symposium, 11 Nov. 2020

  
• 夾雑環境下における曲率認識ペプチドを用いた細胞外膜小胞の検出法の開発

  河野健一、横山文秋、小川拓哉、川本純、栗原達夫、二木史朗

  日本膜学会第42年会, 01 Jun. 2020

  
• 脂質パッキング過疎部位からのポリアルギニンペプチドの細胞内流入

  河野 健一 、阪井 貴之 、村山 知 、今西 未来 、二木 史朗

  第62回 日本脂質生化学会(JCBL2020), 14 May 2020, Invited

  
• Frontier research in membrane curvature on roles as molecular reaction sites

  Kenichi Kawano, Ikuhiko Nakase

  The 140th Annual Meeting of the Pharmaceutical Society of Japan, 27 Mar. 2020, Invited

  
• 膜曲率誘導による膜透過性ペプチドの細胞内送達促進

  河野健一

  IRCCS The 5th Symposium, 18 Nov. 2019, Invited

  
• 人工ドメイン形成による膜物性および細胞形態の変化

  河野 健一、高橋 康史、大谷 亮、木下 祥尚

  膜シンポジウム2019, 13 Nov. 2019

  
• DEVELOPMENT OF A MEMBRANE CURVATURE-SENSING PEPTIDE BASED ON A STRUCTURE–ACTIVITY CORRELATION STUDY

  Kenichi Kawano, Masaya Ogushi, Toshihiro Masuda, and Shiroh Futaki

  The 56th Japanese Peptide Symposium, 23 Oct. 2019

  
• Induction and reversible control of phase separation on living cell membranes

  Kenichi KAWANO; Yasufumi TAKAHASHI; Ryo OHTANI; Masanao KINOSHITA; Shiroh FUTAKI

  The 57th Annual Meeting of The Biophysical Society of Japan, 24 Sep. 2019

  
• 錯体脂質を用いた生細胞膜上における人工ドメイン構築

  河野 健一; 高橋 康史; 大谷 亮; 木下 祥尚

  第13回バイオ関連化学シンポジウム2019, 04 Sep. 2019

  
• 生細胞膜上における相分離の誘発と可逆的制御

  河野健一; 高橋康史; 大谷亮; 木下祥尚; 二木史朗

  第17回フィジカルファーマフォーラム, 03 Sep. 2019

  
• 膜曲率誘導によるオクタアルギニンの膜透過促進

  河野 健一; 村山知; 阪井貴之; 二木史朗

  第3回 統合物質創製化学研究推進機構(IRCCS) 若手の会, 12 Jul. 2019

  
• ペプチドを用いた膜曲率センシング

  河野 健一; 小串 正哉; 益田 俊博; 二木 史朗

  第14回ケミカルバイオロジー学会, 12 Jun. 2019

  
• ペプチドを用いた膜曲率センシング

  河野 健一; 小串 正哉; 益田 俊博; 二木 史朗

  第66回日本生化学会近畿支部例会, 25 May 2019

  
• がん細胞由来のエクソソームを認識する曲率感知ペプチドの開発

  河野 健一; 小串 正哉; 益田 俊博; 二木 史朗

  日本薬学会第139年会, 21 Mar. 2019

  
• がん細胞由来のエクソソームを標的としたペプチドベースの認識ツール開発 －曲率感知ペプチドの選定と評価－

  河野 健一; 小串 正哉; 益田 俊博; 二木 史朗

  第68回 日本薬学会近畿支部総会・大会, 13 Oct. 2018

  
• 高曲率小胞指向性を有する曲率感知ペプチドの開発

  河野健一; 小串正哉; 益田俊博; 二木史朗

  第2回統合物質創製化学研究推進機構(IRCCS)若手の会, 15 Jun. 2018

  
• 脂質小胞を感知する曲率センターペプチドの開発

  河野健一; 小串正哉; 益田俊博; 二木史朗

  第65回日本生化学会近畿支部例会, 26 May 2018

  
• ステープルドペプチドの細胞内移行における疎水性の重要性

  坂上功樹; 益田俊博; 河野健一; 二木史朗

  日本薬学会第138年会, 26 Mar. 2018

  
• Lipid packing loosening plays a key role in the direct membrane translocation of octaarginine

  Tomo Murayama; ◯Kenichi Kawano; Shiroh Futaki

  The Second International Symposium on Biofunctional Chemistry 2017, 14 Dec. 2017

  
• Modification of Lipid Packing State by Amphipathic Peptides with Curvature Inducibility.

  Tomo Murayama; ◯Kenichi Kawano; Shiroh Futaki

  統合物質創製化学研究推進機構 第3回国内シンポジウム, 30 Oct. 2017

  
• 曲率誘導性を有する両親媒性ヘリックスペプチド によるオクタアルギニンの膜透過促進

  河野健一; 村山知; 益田俊博; 二木史朗

  第11回バイオ関連化学シンポジウム, 07 Sep. 2017

  
• 曲率誘導性を有する両親媒性ヘリックスペプチドによるオクタアルギニンの膜透過促進

  村山知; 河野健一; 二木史朗

  統合物質創製化学研究推進機構 (IRCCS) 第一回若手の会, 29 Jul. 2017

  
• Membrane-Remodeling Amphipathic Peptides Facilitate Direct Penetration of Octaarginine (R8)

  村山知; 河野健一; 二木史朗

  日本薬学会第137年会, 25 Mar. 2017

  
• STOICHIOMETRIC ANALYSIS OF OLIGOMERIC STATES OF THREE CLASS-A GPCRS, CHEMOKINE-CXCR4, DOPAMINE-D2, AND PROSTAGLANDIN-EP1 RECEPTORS, ON LIVING CELLS

  ◯Kenichi Kawano; Tetsuya Yagi; Yoshiaki Yano; Katsumi Matsuzaki

  The 53th Japanese Peptide Symposium, 27 Oct. 2016

  
• Cell penetration of dipicolylamine-modified R8 facilitated by metal complex formation

  Shoko Ise; Yoshimasa Kawaguchi; Toshihide Takeuchi; ○Kenichi Kawano; Shiroh Futaki

  34th European Peptide Symposium and 8th International Peptide Symposium, 08 Sep. 2016

  
• Facilitated cell penetration of dipicolylamine-modified R8 by metal complex formation

  Shoko Ise; Yoshimasa Kawaguchi; Toshihide Takeuchi; ◯Kenichi Kawano; Shiroh Futaki

  The 14th Chinese International Peptide Symposium & the 5th Asia-pacific International Peptide Symposium, 05 Jul. 2016

  
• 膜張力変化を介した細胞運動制御ペプチドの開発

  益田俊博; 村山知; 河野健一; 二木史朗

  統合物質創製化学研究推進機構MEXT-IRCCS, 23 Jun. 2016

  
• 新規小分子ラベル法とin-cell FRETを用いた膜タンパク質の会合状態の定量的解析

  河野健一; 矢野義明; 大前薫; 松崎紗矢香; 松崎勝巳

  第64回日本薬学会近畿支部総会・大会, 11 Oct. 2014, Invited

  
• 抗インフルエンザウイルス薬アマンタジン耐性M2 S31N変異株の生体膜中における会合状態

  河野健一; 矢野義明; 松崎勝巳

  日本薬学会第134年会, 28 Mar. 2014

  
• Dimer is a minimal functional unit for influenza A virus M2 channel on biomembrane

  ◯Kenichi Kawano; Yoshiaki Yano; Katsumi Matsuzaki

  4th Asia-Pacific International Peptide Symposium, 06 Nov. 2013

  
• 新規小分子ラベル法とin-cell FRETを用いた膜タンパク質の会合状態の定量的解析

  河野健一; 矢野義明; 大前薫; 松崎紗矢香; 松崎勝巳

  第63回日本薬学会近畿支部総会・大会, 12 Oct. 2013

  
• インフルエンザAウィルスM2プロトンチャネルの生体膜中における会合状態

  河野健一; 松崎紗矢香; 大前薫; 矢野義明; 松崎勝巳

  第34回生体膜と薬物の相互作用シンポジウム, 15 Nov. 2012

  
• Mechanism of antiviral Amantadine resistance of influenza A virus M2 proton channel

  ◯Kenichi Kawano; Sayaka Matsuzaki; Kaoru Oomae; Yoshiaki Yano; Katsumi Matsuzaki

  49th Japanese Peptide Symposium, 07 Nov. 2012

  
• インフルエンザAウィルスM2プロトンチャネルの抗ウィルス薬 アマンタジン耐性メカニズム

  河野健一; 松崎紗矢香; 大前 薫; 矢野義明; 松崎勝巳

  第10回次世代を担う若手のフィジカル・ファーマフォーラム（PPF2012）, 06 Aug. 2012

  
• Stoichiometric analysis of oligomerization of membrane proteins on living cell surface

  ◯Kenichi Kawano; Kaoru Oomae; Sayaka Matsuzaki; Yoshiaki Yano; Katsumi Matsuzaki

  The 7th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists, 24 May 2012

  
• M2プロトンチャネルのpH依存的会合状態の変化

  河野健一; 大前薫; 松崎紗矢香; 矢野義明; 松崎勝巳

  日本薬学会第132年会, 30 Mar. 2012

  
• Family A GPCRの受容体活性に会合体形成は本当に必要か

  河野 健一

  第33回生体膜と薬物の相互作用シンポジウム, 24 Nov. 2011

  
• Family A GPCR の受容体活性に会合体形成は本当に必要か

  河野健一; 大前薫; 矢野義明; 松崎勝巳

  第9回次世代を担う若手のフィジカル・ファーマフォーラム（PPF2011）, 13 Sep. 2011

  
• 新規小分子蛍光ラベル法を用いたβ2アドレナリン受容体の生体膜における会合状態の解析

  河野健一; 矢野義明; 松崎勝巳

  日本ケミカルバイオロジー学会第６回年会, 25 May 2011

  

Awards

• 12 Oct. 2013

  日本薬学会近畿支部, 第63回日本薬学会近畿支部奨励賞

External funds: Kakenhi

• Exploration of adjuvant-active substances derived from extracellular membrane vesicles

  Grant-in-Aid for Early-Career Scientists

  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related

  Kyoto University

  河野 健一

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  細胞外小胞;腸内細菌;アジュバント;免疫細胞;蛍光イメージング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K15254/
• In-cell分光法によるアミロイドβ産生制御機構・構造変化の解明と創薬

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47020:Pharmaceutical analytical chemistry and physicochemistry-related

  Kyoto University

  松崎 勝巳

  From 01 Apr. 2021, To 31 Mar. 2025, Granted

  アルツハイマー病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02615/
• Elucidation of the mechanism underlying the influx point of cell-penetrating peptides using artificial lipid domains

  Grant-in-Aid for Early-Career Scientists

  Basic Section 43040:Biophysics-related

  Kyoto University

  Kenichi Kawano

  From 01 Apr. 2018, To 31 Mar. 2020, Project Closed

  人工脂質ラフト;錯体脂質;細胞膜;境界領域;錯体化学;膜透過性ペプチド;直接膜透過;脂質パッキング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K14664/
• Development of a novel fluorescent labeling method for detecting heterooligomers of membrane proteins on living cells

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Matsuzaki Katsumi

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  蛍光イメージング;膜タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04636/
• New strategy for intracellular delivery of biomacropharmaceuticals

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Shiroh Futaki

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  細胞内送達;抗体;エンドサイトーシス;マクロピノサイトーシス;クモ毒;膜傷害性ペプチド;バイオ医薬品;バイオ高分子医薬品;エンドソーム膜不安定化ペプチド;薬学;蛋白質;細胞;薬物送達

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H02497/
• Structural analysis of Am-resistant M2-S31N mutant using a novel detergent and solution NMR

  Grant-in-Aid for Research Activity Start-up

  Kyoto University

  Kenichi Kawano

  From 29 Aug. 2014, To 31 Mar. 2016, Project Closed

  可溶化剤;M2プロトンチャネル;S31N変異体;溶液NMR;A型インフルエンザウイルス;アマンタジン耐性;二量体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26893117/

External funds: others

• がん細胞由来のエクソソームを標的としたペプチド転移診断薬の開発

  武田科学振興財団 2018年度薬学系研究助成

  From 13 Nov. 2018, To 31 May 2021

  河野健一

Education

Teaching subject(s)

• From Apr. 2017, To Mar. 2018

  Laboratory Practice in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Biofunctional Chemistry Seminar

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory Practice in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Biofunctional Chemistry Seminar

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Biofunctional Chemistry Seminar

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Basic Biofunctional Chemistry

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Biofunctional Chemistry Seminar

  Year-long, 薬学研究科

Administration

Faculty management (title, position)

• From 01 Apr. 2016, To 31 Mar. 2017

  化学研究所情報システム技術委員会 委員
• From 01 Apr. 2017, To 31 Mar. 2018

  化学研究所安全衛生委員会 委員
• From 01 Apr. 2017, To 31 Mar. 2018

  化学研究所情報システム技術委員会 委員
• From 01 Apr. 2018, To 31 Mar. 2019

  化学研究所情報システム技術委員会 委員
• From 01 Apr. 2019, To 31 Mar. 2020

  化学研究所情報システム技術委員会 委員
• From 01 Apr. 2020, To 31 Mar. 2021

  化学研究所広報委員会委員
• From 01 Apr. 2020, To 31 Mar. 2021

  化学研究所情報システム技術委員会委員

Academic, Social Contribution

Committee Memberships

• From Mar. 2020, To Present

  関西支部幹事, 生体関連化学部会 若手の会
• From Aug. 2018, To Present

  幹事, 若手ペプチド夏の勉強会
• From Jul. 2019, To Oct. 2020

  実行委員・事務局, 第42回生体膜と薬物の相互作用シンポジウム(2020)

Academic Contribution

• The 55th Summer Seminar for Young Peptide Scientist

  Planning, management, etc.

  The Japanese Peptide Society, From 08 Aug. 2023, To 10 Aug. 2023

  
• 生体機能関連化学部会若手の会 第33回サマースクール（実行委員長）

  Planning, management, etc.

  日本化学会 生体機能関連化学部会 若手の会, From 13 Jul. 2022, To 14 Jul. 2022

  
• 日本薬学会第141年会 シンポジウム（世話人代表）

  Planning, management, etc.

  日本薬学会, From 29 Mar. 2021

  
• 日本薬学会第140年会 シンポジウム（世話人代表）

  Planning, management, etc.

  日本薬学会, From 27 Mar. 2020

  

Social Contribution

• 日本ペプチド学会市民フォーラム2018（世話人代表）

  Host, Chief editor, Edit, Planner, Logistic support

  日本ペプチド学会, 自然に息づく万能素材「アミノ酸・ペプチド」 ~いのちを支え健康を守る立役者~, From 05 Dec. 2018