Basic Information

Affiliated programs (koza)

• Graduate School of Pharmaceutical Sciences, 薬科学専攻 生体機能化学講座, 教授

Concurrent Affiliation

• 政策のための科学ユニット
• 政策のための科学ユニット

Professional Memberships

• The Pharmaceutical Society of Japan
• 日本生化学会
• アメリカ化学会(American Chemical Society)
• 日本ペプチド学会
• 日本化学会

Academic Degree

• MS(Kyoto University)
• PhD(Kyoto University)

Language of Instruction

• English

ID,URL

• ORCID ID

  0000-0002-0124-4002

• J-Global ID

  200901039325790433

• External link

  http://www.scl.kyoto-u.ac.jp/~bfdc/index.html

Website(s) (URL(s))

• http://www.scl.kyoto-u.ac.jp/‾bfdc/index.html

researchmap URL

• https://researchmap.jp/futaki.shiroh

Research

Research Topics, Overview of the research

• Research Topics

  1. Creation of bioactive proteins that control cell function and genes
  2. Development of peptide-based intracellular delivery systems for biomacromolecules
  3. Design of peptides and proteins that induce membrane curvature
  4. Design of artificial transcription factors that regulate gene expression
  5. Assembly control of membrane proteins and the regulation of biological signals

Research Interests

• ペプチド工学
• 細胞機能化学
• ペプチド化学
• Peptide Engineering
• Cell Functional Chemistry
• Peptide Chemistry

Research Areas

• Life sciences, Pharmaceuticals - health and biochemistry
• Life sciences, Pharmaceuticals - chemistry and drug development
• Nanotechnology/Materials, Molecular biochemistry

Papers

• Optimizing Charge Switching in Membrane Lytic Peptides for Endosomal Release of Biomacromolecules

  Kentarou Sakamoto; Misao Akishiba; Takahiro Iwata; Kazuya Murata; Seiya Mizuno; Kenichi Kawano; Miki Imanishi; Fumihiro Sugiyama; Shiroh Futaki

  Angewandte Chemie, Aug. 2020

  
• KCNN4 as a Genomic Determinant of Cytosolic Delivery by the Attenuated Cationic Lytic Peptide L17E

  Masashi Kuriyama; Hisaaki Hirose; Yoshimasa Kawaguchi; Junya Michibata; Masashi Maekawa; Shiroh Futaki

  Molecular Therapy, Jan. 2025

  
• Highly sequence-specific, timing-controllable m6A demethylation by modulating RNA-binding affinity of m6A erasers.

  Kenko Otonari; Yuri Asami; Kosuke Ogata; Yasushi Ishihama; Shiroh Futaki; Miki Imanishi

  Chemical communications (Cambridge, England), 05 Nov. 2024

  
• Polysaccharide-Based Coacervate Microgel Bearing Cationic Peptides That Achieve Dynamic Cell-Membrane Structure Alteration and Facile Cytosolic Infusion of IgGs.

  Junya Michibata; Yoshimasa Kawaguchi; Hisaaki Hirose; Akiko Eguchi; Sayaka Deguchi; Kazuo Takayama; Wei Xu; Takuro Niidome; Yoshihiro Sasaki; Kazunari Akiyoshi; Shiroh Futaki

  Bioconjugate chemistry, 05 Nov. 2024

  
• Foreword

  Futaki, S.

  Drug Delivery System, 2020

  
• Quality and Safety Considerations for Therapeutic Products Based on Extracellular Vesicles.

  Yoshinobu Takakura; Rikinari Hanayama; Kazunari Akiyoshi; Shiroh Futaki; Kyoko Hida; Takanori Ichiki; Akiko Ishii-Watabe; Masahiko Kuroda; Kazushige Maki; Yasuo Miura; Yoshiaki Okada; Naohiro Seo; Toshihide Takeuchi; Teruhide Yamaguchi; Yusuke Yoshioka

  Pharmaceutical research, Aug. 2024

  
• An approach for the intracellular delivery of IgG via enzymatic ligation with a cell-permeable attenuated cationic amphiphilic lytic peptide.

  Yoshimasa Kawaguchi; Sakahiro Terada; Shiroh Futaki

  Bioorganic & medicinal chemistry, 24 Jul. 2024

  
• Finding ways into the cytosol: Peptide-mediated approaches for delivering proteins into cells.

  Yoshimasa Kawaguchi; Shiroh Futaki

  Current opinion in chemical biology, 20 Jun. 2024

  
• ATP2B4 is an essential gene for epidermal growth factor-induced macropinocytosis in A431 cells.

  Shunsuke Yoshie; Masashi Kuriyama; Masashi Maekawa; Wei Xu; Takuro Niidome; Shiroh Futaki; Hisaaki Hirose

  Genes to cells : devoted to molecular & cellular mechanisms, 10 Apr. 2024

  
• Extracellular Microvesicles Modified with Arginine-Rich Peptides for Active Macropinocytosis Induction and Delivery of Therapeutic Molecules

  Kenta Morimoto; Jojiro Ishitobi; Kosuke Noguchi; Ryoichi Kira; Yukiya Kitayama; Yuto Goto; Daisuke Fujiwara; Masataka Michigami; Atsushi Harada; Tomoka Takatani-Nakase; Ikuo Fujii; Shiroh Futaki; Masamitsu Kanada; Ikuhiko Nakase

  ACS Applied Materials & Interfaces, 02 Apr. 2024

  
• Light-controllable cell-membrane disturbance for intracellular delivery.

  Wenting Huo; Koji Miki; Huiying Mu; Takashi Osawa; Harumi Yamaguma; Yuuya Kasahara; Satoshi Obika; Yoshimasa Kawaguchi; Hisaaki Hirose; Shiroh Futaki; Yusuke Miyazaki; Wataru Shinoda; Shuji Akai; Kouichi Ohe

  Journal of materials chemistry. B, 08 Mar. 2024

  
• Liquid Droplet-Mediated Formulation of Lipid Nanoparticles Encapsulating Immunoglobulin G for Cytosolic Delivery.

  Yusuke Hirai; Yoshimasa Kawaguchi; Chisato Kasahara; Hisaaki Hirose; Shiroh Futaki

  Molecular pharmaceutics, 30 Jan. 2024

  
• E3MPH16: An efficient endosomolytic peptide for intracellular protein delivery.

  Yoshimasa Kawaguchi; Yuki Kawamura; Hisaaki Hirose; Megumi Kiyokawa; Momo Hirate; Tsuyoshi Hirata; Yuriko Higuchi; Shiroh Futaki

  Journal of controlled release : official journal of the Controlled Release Society, 30 Jan. 2024

  
• Inkjet-Based Intracellular Delivery System that Effectively Utilizes Cell-Penetrating Peptides for Cytosolic Introduction of Biomacromolecules through the Cell Membrane

  Mika Omura; Kenta Morimoto; Yurina Araki; Hisaaki Hirose; Yoshimasa Kawaguchi; Yukiya Kitayama; Yuto Goto; Atsushi Harada; Ikuo Fujii; Tomoka Takatani-Nakase; Shiroh Futaki; Ikuhiko Nakase

  ACS Applied Materials & Interfaces, 04 Oct. 2023

  
• Xanthine derivatives inhibit FTO in an L-ascorbic acid-dependent manner.

  Kamui Tanaka; Akiyo Suda; Motonari Uesugi; Shiroh Futaki; Miki Imanishi

  Chemical communications (Cambridge, England), 07 Sep. 2023

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• Macropinoscope: Real-Time Simultaneous Tracking of pH and Cathepsin B Activity in Individual Macropinosomes.

  Hisaaki Hirose; Eiji Nakata; Zhengxiao Zhang; Yuya Shibano; Masashi Maekawa; Takashi Morii; Shiroh Futaki

  Analytical chemistry, 01 Aug. 2023

  
• Disulfiram encapsulated in polymer nanoparticles ameliorates thioacetamide-induced liver injury

  Wei Xu; Yuta Kadoya; Kaito Sennari; Waliul Islam; Tianli Zhang; Tomohiro Sawa; Fumika Akizuki; Hisaaki Hirose; Shiroh Futaki; Yukio Fujiwara; Yoshihiro Komohara; Takuro Niidome

  Journal of Drug Delivery Science and Technology, Sep. 2023

  
• Light-Induced Condensation of Biofunctional Molecules around Targeted Living Cells to Accelerate Cytosolic Delivery.

  Ikuhiko Nakase; Moe Miyai; Kosuke Noguchi; Mamoru Tamura; Yasuyuki Yamamoto; Yushi Nishimura; Mika Omura; Kota Hayashi; Shiroh Futaki; Shiho Tokonami; Takuya Iida

  Nano letters, 28 Dec. 2022

  
• Structural Dissection of Epsin-1 N-Terminal Helical Peptide: The Role of Hydrophobic Residues in Modulating Membrane Curvature.

  Motoki Nishimura; Yoshimasa Kawaguchi; Kakeru Kuroki; Yuna Nakagawa; Toshihiro Masuda; Takayuki Sakai; Kenichi Kawano; Hisaaki Hirose; Miki Imanishi; Tomoka Takatani-Nakase; Sergii Afonin; Anne S Ulrich; Shiroh Futaki

  Chemistry (Weinheim an der Bergstrasse, Germany), 06 Mar. 2023

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• Surface morphology live-cell imaging reveals how macropinocytosis inhibitors affect membrane dynamics

  Hiroki Ida; Noriko Taira; Koichi Azuma; Akichika Kumatani; Misao Akishiba; Shiroh Futaki; Yasufumi Takahashi; Hitoshi Shiku

  Electrochimica Acta, Feb. 2023

  
• Modular Redesign of a Cationic Lytic Peptide To Promote the Endosomal Escape of Biomacromolecules

  Yusuke Azuma; Haruka Imai; Yoshimasa Kawaguchi; Ikuhiko Nakase; Hiroshi Kimura; Shiroh Futaki

  Angewandte Chemie, 24 Sep. 2018, Peer-reviewed

  
• A noncanonical endocytic pathway is involved in the internalization of 3 μm polystyrene beads into HeLa cells.

  Hisaaki Hirose; Masashi Maekawa; Hiroki Ida; Masashi Kuriyama; Yasufumi Takahashi; Shiroh Futaki

  Biomaterials science, 06 Dec. 2022

  
• Publisher Correction: Piezo1 activation using Yoda1 inhibits macropinocytosis in A431 human epidermoid carcinoma cells (Scientific Reports, (2022), 12, 1, (6322), 10.1038/s41598-022-10153-8)

  Masashi Kuriyama; Hisaaki Hirose; Toshihiro Masuda; Masachika Shudou; Jan Vincent V. Arafiles; Miki Imanishi; Masashi Maekawa; Yuji Hara; Shiroh Futaki

  Scientific Reports, Dec. 2022

  
• Piezo1 activation using Yoda1 inhibits macropinocytosis in A431 human epidermoid carcinoma cells

  Masashi Kuriyama; Hisaaki Hirose; Toshihiro Masuda; Masachika Shudou; Jan Vincent Arafiles; Miki Imanishi; Masashi Maekawa; Yuji Hara; Shiroh Futaki

  Scientific Reports, Dec. 2022

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• Quantitative Analysis of Extracellular Vesicle Uptake and Fusion with Recipient Cells.

  Hisaaki Hirose; Yusuke Hirai; Michihito Sasaki; Hirofumi Sawa; Shiroh Futaki

  Bioconjugate chemistry, 04 Oct. 2022

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• Split luciferase-based estimation of cytosolic cargo concentration delivered intracellularly via attenuated cationic amphiphilic lytic peptides

  Syusuke Okano; Yoshimasa Kawaguchi; Kenichi Kawano; Hisaaki Hirose; Miki Imanishi; Shiroh Futaki

  Bioorganic and Medicinal Chemistry Letters, 15 Sep. 2022

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• Hemopexin as a Potential Binding Partner of Arginine-Rich Cell-Penetrating Peptides in Serum

  Kayo Nomura; Kenichi Kawano; Yoshimasa Kawaguchi; Yuki Kawamura; Junya Michibata; Keiko Kuwata; Koji Sugiyama; Kenji Kusumoto; Shiroh Futaki

  ACS Pharmacology and Translational Science, 12 Aug. 2022

  
• Stearylated Macropinocytosis-Inducing Peptides Facilitating the Cellular Uptake of Small Extracellular Vesicles.

  Yuna Nakagawa; Jan Vincent V Arafiles; Yoshimasa Kawaguchi; Ikuhiko Nakase; Hisaaki Hirose; Shiroh Futaki

  Bioconjugate chemistry, 04 May 2022

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• L17ER4: A cell-permeable attenuated cationic amphiphilic lytic peptide

  Kenta Shinga; Takahiro Iwata; Kazuya Murata; Yoko Daitoku; Junya Michibata; Jan Vincent V. Arafiles; Kentarou Sakamoto; Misao Akishiba; Tomoka Takatani-Nakase; Seiya Mizuno; Fumihiro Sugiyama; Miki Imanishi; Shiroh Futaki

  Bioorganic and Medicinal Chemistry, 01 May 2022

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• Dodecaborate-Encapsulated Extracellular Vesicles with Modification of Cell-Penetrating Peptides for Enhancing Macropinocytotic Cellular Uptake and Biological Activity in Boron Neutron Capture Therapy.

  Shiori Hirase; Ayako Aoki; Yoshihide Hattori; Kenta Morimoto; Kosuke Noguchi; Ikuo Fujii; Tomoka Takatani-Nakase; Shiroh Futaki; Mitsunori Kirihata; Ikuhiko Nakase

  Molecular pharmaceutics, 04 Apr. 2022

  
• Synthesis and Properties of V-Shaped Xanthene Dyes with Tunable and Predictable Absorption and Emission Wavelengths.

  Akari Yamagami; Kotaro Kiyotaki; Sae Wakabayashi; Naoki Egami; Kenichi Kawano; Shiroh Futaki; Ayumi Imayoshi; Kazunori Tsubaki

  The Journal of organic chemistry, 04 Mar. 2022

  
• Artificial Nanocage Formed via Self-Assembly of β-Annulus Peptide for Delivering Biofunctional Proteins into Cell Interiors.

  Kentarou Sakamoto; Hiroto Furukawa; Jan Vincent V Arafiles; Miki Imanishi; Kazunori Matsuura; Shiroh Futaki

  Bioconjugate chemistry, 16 Feb. 2022

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• Grafting Hydrophobic Amino Acids Critical for Inhibition of Protein-Protein Interactions on a Cell-Penetrating Peptide Scaffold.

  Yuki Nagano; Jan Vincent V Arafiles; Keiko Kuwata; Yoshimasa Kawaguchi; Miki Imanishi; Hisaaki Hirose; Shiroh Futaki

  Molecular pharmaceutics, 07 Feb. 2022

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• Recognition of G-quadruplex RNA by a crucial RNA methyltransferase component, METTL14.

  Atsuhiro Yoshida; Takanori Oyoshi; Akiyo Suda; Shiroh Futaki; Miki Imanishi

  Nucleic acids research, 11 Jan. 2022

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• Peptide-Mediated Strategies for Intracellular Protein Delivery

  Shiroh Futaki

  Aldrichimica Acta, 2022

  
• 細胞膜の脂質パッキングと細胞内送達

  二木 史朗

  オレオサイエンス, 2022

  
• Protein Delivery to Cytosol by Cell-Penetrating Peptide Bearing Tandem Repeat Penetration-Accelerating Sequence

  Akiko Okuda; Shiroh Futaki

  Methods in Molecular Biology, 2022

  
• Direct entry of cell-penetrating peptide can be controlled by maneuvering the membrane curvature

  Kazutami Sakamoto; Taku Morishita; Kenichi Aburai; Daisuke Ito; Tomohiro Imura; Kenichi Sakai; Masahiko Abe; Ikuhiko Nakase; Shiroh Futaki; Hideki Sakai

  Scientific Reports, Dec. 2021

  
• Cytosolic protein delivery using pH-responsive, charge-reversible lipid nanoparticles.

  Yusuke Hirai; Hisaaki Hirose; Miki Imanishi; Tomohiro Asai; Shiroh Futaki

  Scientific reports, 06 Oct. 2021

  
• Membrane anchoring of a curvature-inducing peptide, EpN18, promotes membrane translocation of octaarginine

  Kakeru Kuroki; Takayuki Sakai; Toshihiro Masuda; Kenichi Kawano; Shiroh Futaki

  Bioorganic and Medicinal Chemistry Letters, 01 Jul. 2021

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• A facile combinatorial approach to construct a ratiometric fluorescent sensor: application for the real-time sensing of cellular pH changes

  Eiji Nakata; Hisaaki Hirose; Khongorzul Gerelbaatar; Jan Vincent V. Arafiles; Zhengxiao Zhang; Shiroh Futaki; Takashi Morii

  Chemical Science, 21 Jun. 2021

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• Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides.

  Takahiro Iwata; Hisaaki Hirose; Kentarou Sakamoto; Yusuke Hirai; Jan Vincent V Arafiles; Misao Akishiba; Miki Imanishi; Shiroh Futaki

  Angewandte Chemie (International ed. in English), 11 Jun. 2021

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• Chemical passports to cross biological borders

  Jan Vincent V. Arafiles; Shiroh Futaki

  Nature Chemistry, Jun. 2021

  
• Influence of the Dabcyl group on the cellular uptake of cationic peptides: short oligoarginines as efficient cell-penetrating peptides.

  Ildikó Szabó; Françoise Illien; Levente E Dókus; Mo'ath Yousef; Zsuzsa Baranyai; Szilvia Bősze; Shoko Ise; Kenichi Kawano; Sandrine Sagan; Shiroh Futaki; Ferenc Hudecz; Zoltán Bánóczi

  Amino acids, 25 May 2021

  
• Potentiating the Membrane Interaction of an Attenuated Cationic Amphiphilic Lytic Peptide for Intracellular Protein Delivery by Anchoring with Pyrene Moiety

  Kentarou Sakamoto; Junya Michibata; Yusuke Hirai; Akiko Ide; Asuka Ikitoh; Tomoka Takatani-Nakase; Shiroh Futaki

  Bioconjugate Chemistry, 19 May 2021

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• Discovery of a Macropinocytosis-Inducing Peptide Potentiated by Medium-Mediated Intramolecular Disulfide Formation

  Jan Vincent V. Arafiles; Hisaaki Hirose; Yusuke Hirai; Masashi Kuriyama; Maxwell Mamfe Sakyiamah; Wataru Nomura; Kazuhiro Sonomura; Miki Imanishi; Akira Otaka; Hirokazu Tamamura; Shiroh Futaki

  Angewandte Chemie - International Edition, 17 May 2021

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• Use of homoarginine to obtain attenuated cationic membrane lytic peptides

  Kentarou Sakamoto; Misao Akishiba; Takahiro Iwata; Jan Vincent V. Arafiles; Miki Imanishi; Shiroh Futaki

  Bioorganic & medicinal chemistry letters, 15 May 2021

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• Nanoscale Visualization of Morphological Alteration of Live-Cell Membranes by the Interaction with Oligoarginine Cell-Penetrating Peptides

  Hiroki Ida; Yasufumi Takahashi; Akichika Kumatani; Hitoshi Shiku; Tomo Murayama; Hisaaki Hirose; Shiroh Futaki; Tomokazu Matsue

  Analytical Chemistry, Apr. 2021

  
• Environmental pH stress influences cellular secretion and uptake of extracellular vesicles

  Ikuhiko Nakase; Natsumi Ueno; Mie Matsuzawa; Kosuke Noguchi; Mami Hirano; Mika Omura; Tomoya Takenaka; Ayaka Sugiyama; Nahoko Bailey Kobayashi; Takuya Hashimoto; Tomoka Takatani-Nakase; Eiji Yuba; Ikuo Fujii; Shiroh Futaki; Tetsuhiko Yoshida

  FEBS Open Bio, Mar. 2021

  
• 送達ペプチドを用いた抗体の細胞内導入の試み

  二木 史朗

  BIO Clinica, 2021

  
• マクロピノサイトーシスを活用した細胞内送達の可能性

  二木 史朗

  生化学, 2021

  
• Design of the N-Terminus Substituted Curvature-Sensing Peptides That Exhibit Highly Sensitive Detection Ability of Bacterial Extracellular Vesicles.

  Kenichi Kawano; Fumiaki Yokoyama; Kouhei Kamasaka; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara; Shiroh Futaki

  Chemical & pharmaceutical bulletin, 2021

  
• Functional Peptides That Target Biomembranes: Design and Modes of Action.

  Shiroh Futaki

  Chemical & pharmaceutical bulletin, 2021

  
• Effect of Surface Modifications on Cellular Uptake of Gold Nanorods in Human Primary Cells and Established Cell Lines.

  Yuxiang Xiao; Wei Xu; Yoshihiro Komohara; Yukio Fujiwara; Hisaaki Hirose; Shiroh Futaki; Takuro Niidome

  ACS omega, 22 Dec. 2020

  
• Development of a Simple and Rapid Method for In Situ Vesicle Detection in Cultured Media

  Kenichi Kawano; Fumiaki Yokoyama; Jun Kawamoto; Takuya Ogawa; Tatsuo Kurihara; Shiroh Futaki

  Journal of Molecular Biology, 06 Nov. 2020, Peer-reviewed

  
• Optimizing Charge Switching in Membrane Lytic Peptides for Endosomal Release of Biomacromolecules

  Kentarou Sakamoto; Misao Akishiba; Takahiro Iwata; Kazuya Murata; Seiya Mizuno; Kenichi Kawano; Miki Imanishi; Fumihiro Sugiyama; Shiroh Futaki

  Angewandte Chemie - International Edition, 02 Nov. 2020, Peer-reviewed

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• Design and creation of functional membrane-interacting peptides

  Shiroh Futaki

  Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 01 Nov. 2020

  
• Pseudo-Membrane Jackets: Two-Dimensional Coordination Polymers Achieving Visible Phase Separation in Cell Membrane

  Ryo Ohtani; Kenichi Kawano; Masanao Kinoshita; Saeko Yanaka; Hikaru Watanabe; Kenji Hirai; Shiroh Futaki; Nobuaki Matsumori; Hiroshi Uji-i; Masaaki Ohba; Koichi Kato; Shinya Hayami

  Angewandte Chemie - International Edition, 05 Oct. 2020, Peer-reviewed

  
• Effective RNA regulation by combination of multiple programmable RNA-binding proteins

  Misaki Sugimoto; Akiyo Suda; Shiroh Futaki; Miki Imanishi

  Applied Sciences (Switzerland), 01 Oct. 2020

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• Effect of vesicle size on the cytolysis of cell‐ penetrating peptides (CPPS)

  Kazutami Sakamoto; Takeshi Kitano; Haruka Kuwahara; Megumi Tedani; Kenichi Aburai; Shiroh Futaki; Masahiko Abe; Hideki Sakai; Hiroyasu Ohtaka; Yuji Yamashita

  International Journal of Molecular Sciences, 01 Oct. 2020, Peer-reviewed

  
• Improved cytosolic delivery of macromolecules through dimerization of attenuated lytic peptides

  Yohei Nomura; Kentarou Sakamoto; Misao Akishiba; Takahiro Iwata; Hisaaki Hirose; Shiroh Futaki

  Bioorganic and Medicinal Chemistry Letters, 01 Sep. 2020, Peer-reviewed

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• Key process and factors controlling the direct translocation of cell-penetrating peptide through bio-membrane

  Taku Morishita; Kenichi Aburai; Kenichi Sakai; Masahiko Abe; Ikuhiko Nakase; Shiroh Futaki; Hideki Sakai; Kazutami Sakamoto

  International Journal of Molecular Sciences, 01 Aug. 2020, Peer-reviewed

  
• An Artificial Amphiphilic Peptide Promotes Endocytic Uptake by Inducing Membrane Curvature

  Toshihiro Masuda; Hisaaki Hirose; Kentarou Baba; Astrid Walrant; Sandrine Sagan; Naoyuki Inagaki; Toyoshi Fujimoto; Shiroh Futaki

  Bioconjugate Chemistry, 17 Jun. 2020, Peer-reviewed

  
• Enhancing the activity of membrane remodeling epsin-peptide by trimerization

  Wei Yuan Hsu; Toshihiro Masuda; Sergii Afonin; Takayuki Sakai; Jan Vincent V. Arafiles; Kenichi Kawano; Hisaaki Hirose; Miki Imanishi; Anne S. Ulrich; Shiroh Futaki

  Bioorganic and Medicinal Chemistry Letters, 15 Jun. 2020, Peer-reviewed

  
• Rational Design Principles of Attenuated Cationic Lytic Peptides for Intracellular Delivery of Biomacromolecules.

  Naoki Tamemoto; Misao Akishiba; Kentarou Sakamoto; Kenichi Kawano; Hiroshi Noguchi; Shiroh Futaki

  Molecular pharmaceutics, 01 Jun. 2020, Peer-reviewed

  
• Peptide-assisted intracellular delivery of biomacromolecules

  Shiroh Futaki; Jan Vincent V. Arafiles; Hisaaki Hirose

  Chemistry Letters, Jun. 2020

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• Stimulating Macropinocytosis for Intracellular Nucleic Acid and Protein Delivery: A Combined Strategy with Membrane-Lytic Peptides To Facilitate Endosomal Escape.

  Jan Vincent V Arafiles; Hisaaki Hirose; Misao Akishiba; Shogo Tsuji; Miki Imanishi; Shiroh Futaki

  Bioconjugate chemistry, 18 Mar. 2020, Peer-reviewed

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• Programmable RNA methylation and demethylation using PUF RNA binding proteins.

  Kouki Shinoda; Akiyo Suda; Kenko Otonari; Shiroh Futaki; Miki Imanishi

  Chemical communications (Cambridge, England), 28 Jan. 2020, Peer-reviewed

  
• Conversion of cationic amphiphilic lytic peptides to cell-penetration peptides

  Hao-Hsin Yu; Kentarou Sakamoto; Misao Akishiba; Naoki Tamemoto; Hisaaki Hirose; Ikuhiko Nakase; Miki Imanishi; Fatemeh Madani; Astrid Graslund; Shiroh Futaki

  PEPTIDE SCIENCE, Jan. 2020, Peer-reviewed

  
• Loosening of Lipid Packing by Cell-Surface Recruitment of Amphiphilic Peptides by Coiled-Coil Tethering.

  Takayuki Sakai; Kenichi Kawano; Masatomo Iino; Toshihide Takeuchi; Miki Imanishi; Shiroh Futaki

  Chembiochem : a European journal of chemical biology, 16 Aug. 2019, Peer-reviewed

  
• 細胞膜透過型アルブミンの細胞内移行機序の解明 マクロピノサイトーシス誘導とエンドソーム脱出経路

  一水 翔太; 渡邊 博志; 前田 仁志; 清水 太郎; 異島 優; 石田 竜弘; 二木 史朗; 小田切 優樹; 丸山 徹

  日本DDS学会学術集会プログラム予稿集, Jun. 2019, Peer-reviewed

  
• Inducible Membrane Permeabilization by Attenuated Lytic Peptides: A New Concept for Accessing Cell Interiors through Ruffled Membranes

  Akishiba, M.; Futaki, S.

  Molecular Pharmaceutics, 2019, Peer-reviewed

  
• An influenza-derived membrane tension-modulating peptide regulates cell movement and morphology via actin remodeling

  Masuda, T.; Baba, K.; Nomura, T.; Tsujita, K.; Murayama, T.; Itoh, T.; Takatani-Nakase, T.; Sokabe, M.; Inagaki, N.; Futaki, S.

  Communications Biology, 2019, Peer-reviewed

  
• Development of a membrane curvature-sensing peptide based on a structure – Activity correlation study

  Kawano, K.; Ogushi, M.; Masuda, T.; Futaki, S.

  Chemical and Pharmaceutical Bulletin, 2019, Peer-reviewed

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• Meeting Peptides in Kyoto

  Futaki, S.; Matsuzaki, K.; Goto, Y.

  ChemBioChem, 2019, Peer-reviewed

  
• Dipicolylamine/Metal Complexes that Promote Direct Cell-Membrane Penetration of Octaarginine

  Kawaguchi, Y.; Ise, S.; Azuma, Y.; Takeuchi, T.; Kawano, K.; Le, T.K.; Ohkanda, J.; Futaki, S.

  Bioconjugate Chemistry, 2019, Peer-reviewed

  
• Oligoarginine-Bearing Tandem Repeat Penetration-Accelerating Sequence Delivers Protein to Cytosol via Caveolae-Mediated Endocytosis

  Okuda, A.; Tahara, S.; Hirose, H.; Takeuchi, T.; Nakase, I.; Ono, A.; Takehashi, M.; Tanaka, S.; Futaki, S.

  Biomacromolecules, 2019, Peer-reviewed

  
• Cell-penetrating mechanism of intracellular targeting albumin: Contribution of macropinocytosis induction and endosomal escape

  Ichimizu, S.; Watanabe, H.; Maeda, H.; Hamasaki, K.; Ikegami, K.; Chuang, V.T.G.; Kinoshita, R.; Nishida, K.; Shimizu, T.; Ishima, Y.; Ishida, T.; Seki, T.; Katsuki, H.; Futaki, S.; Otagiri, M.; Maruyama, T.

  Journal of Controlled Release, 2019, Peer-reviewed

  
• Intracellular target delivery of cell-penetrating peptide-conjugated dodecaborate for boron neutron capture therapy (BNCT)

  Nakase, I.; Katayama, M.; Hattori, Y.; Ishimura, M.; Inaura, S.; Fujiwara, D.; Takatani-Nakase, T.; Fujii, I.; Futaki, S.; Kirihata, M.

  Chemical Communications, 2019, Peer-reviewed

  
• Arginine-rich cell-penetrating peptide-modified exosomes for macropinocytosis induction and effective cellular uptake

  Noguchi Kosuke; Aoki Ayako; Kobayashi Nahoko Bailey; Takatani-Nakase Tomoka; Yoshida Tetsuhiko; Fujii Ikuo; Futaki Shiroh; Nakase Ikuhiko

  JOURNAL OF PEPTIDE SCIENCE, Sep. 2018, Peer-reviewed

  
• Sequence-specific 5mC detection in live cells based on the TALE-split luciferase complementation system

  Shogo Tsuji; Kouki Shinoda; Shiroh Futaki; Miki Imanishi

  ANALYST, Aug. 2018, Peer-reviewed

  
• Modular Redesign of a Cationic Lytic Peptide To Promote the Endosomal Escape of Biomacromolecules

  Azuma, Y.; Imai, H.; Kawaguchi, Y.; Nakase, I.; Kimura, H.; Futaki, S.

  Angewandte Chemie - International Edition, 2018, Peer-reviewed

  
• バイオ中分子・高分子の細胞内移行・送達にかかわる新しい視点

  二木史朗

  ファルマシア, 2018, Peer-reviewed

  
• Nested PUF Proteins: Extending Target RNA Elements for Gene Regulation

  Shinoda, K.; Tsuji, S.; Futaki, S.; Imanishi, M.

  ChemBioChem, 2018, Peer-reviewed

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• Development of xanthene dyes containing arylacetylenes: The role of acetylene linker and substituents on the aryl group

  Hirata, R.; Torii, A.; Kawano, K.; Futaki, S.; Imayoshi, A.; Tsubaki, K.

  Tetrahedron, 2018, Peer-reviewed

  
• Importance of Net Hydrophobicity in the Cellular Uptake of All-Hydrocarbon Stapled Peptides

  Sakagami, K.; Masuda, T.; Kawano, K.; Futaki, S.

  Molecular Pharmaceutics, 2018, Peer-reviewed

  
• Design and tuning of a cell-penetrating albumin derivative as a versatile nanovehicle for intracellular drug delivery

  Ichimizu, S.; Watanabe, H.; Maeda, H.; Hamasaki, K.; Nakamura, Y.; Chuang, V.T.G.; Kinoshita, R.; Nishida, K.; Tanaka, R.; Enoki, Y.; Ishima, Y.; Kuniyasu, A.; Kobashigawa, Y.; Morioka, H.; Futaki, S.; Otagiri, M.; Maruyama, T.

  Journal of Controlled Release, 2018, Peer-reviewed

  
• Syntheses and properties of second-generation V-shaped xanthene dyes with piperidino groups

  Akari Yamagami; Kenichi Kawano; Shiroh Futaki; Kouji Kuramochi; Kazunori Tsubaki

  TETRAHEDRON, Dec. 2017, Peer-reviewed

  
• Increased hydrophobic block length of PTDMs promotes protein internalization (vol 7, pg 7514, 2016)

  Coralie M. Backlund; Federica Sgolastra; Ronja Otter; Lisa M. Minter; Toshihide Takeuchi; Shiroh Futaki; Gregory N. Tew

  POLYMER CHEMISTRY, Nov. 2017, Peer-reviewed

  
• Photoaffinity labeling methods to explore internalization mechanisms of arginine-rich cell-penetrating peptides

  Gen Tanaka; Yoshimasa Kawaguchi; Keiko Kuwata; Toshihide Takeuchi; Ikuhiko Nakase; Shiroh Futaki

  Photoaffinity Labeling for Structural Probing Within Protein, 25 Sep. 2017

  
• Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide

  Misao Akishiba; Toshihide Takeuchi; Yoshimasa Kawaguchi; Kentarou Sakamoto; Hao-Hsin Yu; Ikuhiko Nakase; Tomoka Takatani-Nakase; Fatemeh Madani; Astrid Graslund; Shiroh Futaki

  NATURE CHEMISTRY, Aug. 2017, Peer-reviewed

  
• Loosening of Lipid Packing Promotes Oligoarginine Entry into Cells

  Tomo Murayama; Toshihiro Masuda; Sergii Afonin; Kenichi Kawano; Tomoka Takatani-Nakase; Hiroki Ida; Yasufumi Takahashi; Takeshi Fukuma; Anne S. Ulrich; Shiroh Futaki

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Jun. 2017, Peer-reviewed

  
• Receptor clustering and activation by multivalent interaction through recognition peptides presented on exosomes

  I. Nakase; N. Ueno; M. Katayama; K. Noguchi; T. Takatani-Nakase; N. B. Kobayashi; T. Yoshida; I. Fujii; S. Futaki

  CHEMICAL COMMUNICATIONS, Jan. 2017

  
• Cell-Surface Interactions on Arginine-Rich Cell-Penetrating Peptides Allow for Multiplex Modes of Internalization

  Futaki, S.; Nakase, I.

  Accounts of Chemical Research, 2017, Peer-reviewed

  
• Membrane translocation of arginine-rich cell-penetrating peptides

  Shiroh Futaki

  Seikagaku, 2017

  
• Cytosolic antibody delivery by lipid-sensitive endosomolytic peptide

  Akishiba, M.; Takeuchi, T.; Kawaguchi, Y.; Sakamoto, K.; Yu, H.-H.; Nakase, I.; Takatani-Nakase, T.; Madani, F.; Gräslund, A.; Futaki, S.

  Nature Chemistry, 2017, Peer-reviewed

  
• Detection of: N ⁶-methyladenosine based on the methyl-sensitivity of MazF RNA endonuclease

  Imanishi, M.; Tsuji, S.; Suda, A.; Futaki, S.

  Chemical Communications, 2017, Peer-reviewed

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• Calmodulin EF-hand peptides as Ca²⁺-switchable recognition tags

  Oku, A.; Imanishi, M.; Noshiro, D.; Murayama, T.; Takeuchi, T.; Nakase, I.; Futaki, S.

  Biopolymers, 2017, Peer-reviewed

  
• Arginine-rich cell-penetrating peptide-modified extracellular vesicles for active macropinocytosis induction and efficient intracellular delivery

  Nakase, I.; Noguchi, K.; Aoki, A.; Takatani-Nakase, T.; Fujii, I.; Futaki, S.

  Scientific Reports, 2017, Peer-reviewed

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• Sequence-specific recognition of methylated DNA by an engineered transcription activator-like effector protein.

  Tsuji S; Futaki S; Imanishi M

  Chemical communications (Cambridge, England), Dec. 2016, Peer-reviewed

  
• Cholesterol-Lowering Effect of Octaarginine-Appended beta-Cyclodextrin in Npc1-Trap-CHO Cells

  Keiichi Motoyama; Rena Nishiyama; Yuki Maeda; Taishi Higashi; Yoshimasa Kawaguchi; Shiroh Futaki; Yoichi Ishitsuka; Yuki Kondo; Tetsumi Irie; Takumi Era; Hidetoshi Arima

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Nov. 2016, Peer-reviewed

  
• Current Understanding of Direct Translocation of Arginine-Rich Cell-Penetrating Peptides and Its Internalization Mechanisms

  Toshihide Takeuchi; Shiroh Futaki

  CHEMICAL & PHARMACEUTICAL BULLETIN, Oct. 2016, Peer-reviewed

  
• Vectorization of biomacromolecules into cells using extracellular vesicles with enhanced internalization induced by macropinocytosis

  Ikuhiko Nakase; Kosuke Noguchi; Ikuo Fujii; Shiroh Futaki

  SCIENTIFIC REPORTS, Oct. 2016, Peer-reviewed

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• Relating structure and internalization for ROMP-based protein mimics

  Backlund, C.M.; Takeuchi, T.; Futaki, S.; Tew, G.N.

  Biochimica et Biophysica Acta - Biomembranes, Jul. 2016, Peer-reviewed

  
• Preparation of Peptide Thioesters From Naturally Occurring Sequences Using Reaction Sequence Consisting of Regioselective S-Cyanylation and Hydrazinolysis

  Rin Miyajima; Yusuke Tsuda; Tsubasa Inokuma; Akira Shigenaga; Miki Imanishi; Shiroh Futaki; Akira Otaka

  BIOPOLYMERS, Jul. 2016, Peer-reviewed

  
• Relating structure and internalization for ROMP-based protein mimics

  Coralie M. Backlund; Toshihide Takeuchi; Shiroh Futaki; Gregory N. Tew

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Jul. 2016, Peer-reviewed

  
• Effect of Amino Acid Substitution in the Hydrophobic Face of Amphiphilic Peptides on Membrane Curvature and Perturbation: N-Terminal Helix Derived From Adenovirus Internal Protein VI As a Model

  Tomo Murayama; Silvia Pujals; Hisaaki Hirose; Ikuhiko Nakase; Shiroh Futaki

  BIOPOLYMERS, Jul. 2016, Peer-reviewed

  
• Syndecan-4 Is a Receptor for Clathrin-Mediated Endocytosis of Arginine-Rich Cell-Penetrating Peptides.

  Yoshimasa Kawaguchi; Toshihide Takeuchi; Keiko Kuwata; Junya Chiba; Yasumaru Hatanaka; Ikuhiko Nakase; Shiroh Futaki

  Bioconjugate chemistry, 20 Apr. 2016, Peer-reviewed

  
• Increased hydrophobic block length of PTDMs promotes protein internalization

  Coralie M. Backlund; Federica Sgolastra; Ronja Otter; Lisa M. Minter; Toshihide Takeuchi; Shiroh Futaki; Gregory N. Tew

  POLYMER CHEMISTRY, 2016, Peer-reviewed

  
• Sequence-specific recognition of methylated DNA by an engineered transcription activator-like effector protein

  Shogo Tsuji; Shiroh Futaki; Miki Imanishi

  CHEMICAL COMMUNICATIONS, 2016, Peer-reviewed

  
• Erratum: Suppressive effect of membrane-permeable peptides derived from autophosphorylation sites of the IGF-1 receptor on breast cancer cells (European Journal of Pharmacology (2015) 765 24-33))

  Yoshihiro Kuroda; Nahoko Kato-Kogoe; Emi Tasaki; Mayumi Yuasa-Sunagawa; Koji Yamanegi; Keiji Nakasyo; Ikuhiko Nakase; Shiroh Futaki; Yumi Tohyama; Munetaka Hirose

  European Journal of Pharmacology, 15 Nov. 2015, Peer-reviewed

  
• Suppressive effect of membrane-permeable peptides derived from autophosphorylation sites of the IGF-1 receptor on breast cancer cells (vol 765, pg 24, 2015)

  Yoshihiro Kuroda; Nahoko Kato-Kogoe; Emi Tasaki; Mayumi Yuasa-Sunagawa; Koji Yamanegi; Keiji Nakasho; Ikuhiko Nakase; Shiroh Futaki; Yumi Tohyama; Munetaka Hirose

  EUROPEAN JOURNAL OF PHARMACOLOGY, Nov. 2015

  
• Suppressive effect of membrane-permeable peptides derived from autophosphorylation sites of the IGF-1 receptor on breast cancer cells

  Yoshihiro Kuroda; Nahoko Kato-Kogoe; Emi Tasaki; Mayumi Yuasa-Sunagawa; Koji Yamanegi; Keiji Nakasyo; Ikuhiko Nakase; Shiroh Futaki; Yumi Tohyama; Munetaka Hirose

  EUROPEAN JOURNAL OF PHARMACOLOGY, Oct. 2015, Peer-reviewed

  
• Determining the relationship between structure, internalization, and delivery efficiency for protein mimics

  Backlund Coralie; Takeuchi Toshihide; Futaki Shiroh; Tew Gregory

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 16 Aug. 2015, Peer-reviewed

  
• Cell penetrating peptides for chemical biological studies

  Ikuhiko Nakase; Toshihide Takeuchi; Shiroh Futaki

  Cell-Penetrating Peptides: Methods and Protocols, 22 Jul. 2015, Peer-reviewed

  
• Combined treatment with a pH-sensitive fusogenic peptide and cationic lipids achieves enhanced cytosolic delivery of exosomes

  Ikuhiko Nakase; Shiroh Futaki

  SCIENTIFIC REPORTS, May 2015, Peer-reviewed

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• Intercellular chaperone transmission via exosomes contributes to maintenance of protein homeostasis at the organismal level

  Toshihide Takeuchi; Mari Suzuki; Nobuhiro Fujikake; H. Akiko Popiel; Hisae Kikuchi; Shiroh Futaki; Keiji Wada; Yoshitaka Nagai

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2015, Peer-reviewed

  
• Cellular Uptake of Arginine-Rich Cell-Penetrating Peptides and the Contribution of Membrane-Associated Proteoglycans

  Ikuhiko Nakase; Yoshimasa Kawaguchi; Motoyoshi Nomizu; Shiroh Futaki

  TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, May 2015, Peer-reviewed, Invited

  
• Functional Peptide-based Intracellular Delivery

  中瀬 生彦; 二木 史朗

  化學工業, Nov. 2014

  
• コラーゲン様3重らせん構造を持つペプチドのバイオツールとしての応用

  増田 亮; 山崎 ちさと; 中瀬 生彦; 山本 和宏; 能勢 博; 二木 史朗; 安井 裕之; 小出 隆規

  日本結合組織学会学術大会・マトリックス研究会大会合同学術集会プログラム・抄録集, Jun. 2014

  
• Molecular interplays involved in the cellular uptake of octaarginine on cell surfaces and the importance of syndecan-4 cytoplasmic V domain for the activation of protein kinase C alpha

  Ikuhiko Nakase; Katsuhiro Osaki; Gen Tanaka; Atsushi Utani; Shiroh Futaki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2014, Peer-reviewed

  
• Controlling leucine-zipper partner recognition in cells through modification of a-g interactions

  Yusuke Azuma; Tim Kuekenshoener; Guangyong Ma; Jun-ichiro Yasunaga; Miki Imanishi; Gen Tanaka; Ikuhiko Nakase; Takahiro Maruno; Yuji Kobayashi; Katja M. Arndt; Masao Matsuoka; Shiroh Futaki

  CHEMICAL COMMUNICATIONS, 2014, Peer-reviewed

  
• Peptide-Based Therapeutic Approaches for Treatment of the Polyglutamine Diseases

  Toshihide Takeuchi; H. Akiko Popiel; Shiroh Futaki; Keiji Wada; Yoshitaka Nagai

  CURRENT MEDICINAL CHEMISTRY, 2014, Peer-reviewed

  
• Extramembrane control of ion channel peptide assemblies, using alamethicin as an example

  Shiroh Futaki; Daisuke Noshiro; Tatsuto Kiwada; Koji Asami

  Accounts of Chemical Research, 17 Dec. 2013, Peer-reviewed

  
• Erratum: A cyclochiral conformational motif constructed using a robust hydrogen-bonding network (Journal of the American Chemical Society (2013) 135 (13644-13647) DOI: 10.1021/ja407051k)

  Kenji Mishiro; Takumi Furuta; Takahiro Sasamori; Kazuhiro Hayashi; Norihiro Tokitoh; Shiroh Futaki; Takeo Kawabata

  Journal of the American Chemical Society, 13 Nov. 2013

  
• Development of a Novel Nanoparticle by Dual Modification With the Pluripotential Cell-Penetrating Peptide PepFect6 for Cellular Uptake, Endosomal Escape, and Decondensation of an siRNA Core Complex

  Asako Mitsueda; Yuri Shimatani; Masahiro Ito; Takashi Ohgita; Asako Yamada; Susumu Hama; Astrid Graslund; Staffan Lindberg; Ulo Langel; Hideyoshi Harashima; Ikuhiko Nakase; Shiroh Futaki; Kentaro Kogure

  BIOPOLYMERS, Nov. 2013, Peer-reviewed

  
• Creating a TALE protein with unbiased 5 '-T binding

  Shogo Tsuji; Shiroh Futaki; Miki Imanishi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2013, Peer-reviewed

  
• Curvature engineering: positive membrane curvature induced by epsin N-terminal peptide boosts internalization of octaarginine.

  Sílvia Pujals; Hiroki Miyamae; Sergii Afonin; Tomo Murayama; Hisaaki Hirose; Ikuhiko Nakase; Kentaro Taniuchi; Masato Umeda; Kazutami Sakamoto; Anne S Ulrich; Shiroh Futaki

  ACS chemical biology, 20 Sep. 2013, Peer-reviewed

  
• Effects of pyrenebutyrate on the translocation of arginine-rich cell-penetrating peptides through artificial membranes: Recruiting peptides to the membranes, dissipating liquid-ordered phases, and inducing curvature

  S. Katayama; I. Nakase; Y. Yano; T. Murayama; Y. Nakata; K. Matsuzaki; S. Futaki

  Biochimica et Biophysica Acta - Biomembranes, Sep. 2013, Peer-reviewed

  
• A Cyclochiral Conformational Motif Constructed Using a Robust Hydrogen-Bonding Network

  Kenji Mishiro; Takumi Furuta; Takahiro Sasamori; Kazuhiro Hayashi; Norihiro Tokitoh; Shiroh Futaki; Takeo Kawabata

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2013, Peer-reviewed

  
• Effects of pyrenebutyrate on the translocation of arginine-rich cell-penetrating peptides through artificial membranes: Recruiting peptides to the membranes, dissipating liquid-ordered phases, and inducing curvature

  Sayaka Katayama; Ikuhiko Nakase; Yoshiaki Yano; Tomo Murayama; Yasushi Nakata; Katsumi Matsuzaki; Shiroh Futaki

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Sep. 2013, Peer-reviewed

  
• Identification of cellular proteins interacting with octaarginine (R8) cell-penetrating peptide by photo-crosslinking

  Yoshimasa Kawaguchi; Gen Tanaka; Ikuhiko Nakase; Miki Imanishi; Junya Chiba; Yasumaru Hatanaka; Shiroh Futaki

  Bioorganic and Medicinal Chemistry Letters, 01 Jul. 2013, Peer-reviewed

  
• Dynamic Amphiphile Libraries To Screen for the "Fragrant" Delivery of siRNA into HeLa Cells and Human Primary Fibroblasts

  Charlotte Gehin; Javier Montenegro; Eun-Kyoung Bang; Ana Cajaraville; Shota Takayama; Hisaaki Hirose; Shiroh Futaki; Stefan Matile; Howard Riezman

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 2013, Peer-reviewed

  
• Modeling the endosomal escape of cell-penetrating peptides using a transmembrane pH gradient

  Fatemeh Madani; Rania Abdo; Staffan Lindberg; Hisaaki Hirose; Shiroh Futaki; Ulo Langel; Astrid Graslund

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Apr. 2013, Peer-reviewed

  
• Construction of a Ca2+-gated artificial channel by fusing alamethicin with a calmodulin-derived extramembrane segment

  Daisuke Noshiro; Kazuhiro Sonomura; Hao-Hsin Yu; Miki Imanishi; Koji Asami; Shiroh Futaki

  Bioconjugate Chemistry, 20 Feb. 2013, Peer-reviewed

  
• Oligopeptides derived from autophosphorylation sites of EGF receptor suppress EGF-stimulated responses in human lung carcinoma A549 cells

  Yoshihiro Kuroda; Nahoko Kato-Kogoe; Emi Tasaki; Eri Murata; Koyo Ueda; Mineo Abe; Kazuhide Miyamoto; Ikuhiko Nakase; Shiroh Futaki; Yumi Tohyama; Munetaka Hirose

  European Journal of Pharmacology, 05 Jan. 2013, Peer-reviewed

  
• Arginine-rich peptides: Methods of translocation through biological membranes

  Shiroh Futaki; Hisaaki Hirose; Ikuhiko Nakase

  Current Pharmaceutical Design, 2013, Peer-reviewed

  
• Collagen-like Cell-Penetrating Peptides

  Chisato M. Yamazaki; Ikuhiko Nakase; Hiroyuki Endo; Saya Kishimoto; Yoshihiro Mashiyama; Ryo Masuda; Shiroh Futaki; Takaki Koide

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, Peer-reviewed

  
• Cell-penetrating peptides (CPPs) as a vector for the delivery of siRNAs into cells

  Ikuhiko Nakase; Gen Tanaka; Shiroh Futaki

  MOLECULAR BIOSYSTEMS, 2013, Peer-reviewed

  
• Control of leakage activities of alamethicin analogs by metals: Side chain-dependent adverse gating response to Zn2+

  Daisuke Noshiro; Koji Asami; Shiroh Futaki

  BIOORGANIC & MEDICINAL CHEMISTRY, Dec. 2012, Peer-reviewed

  
• Induction of autophagic cell death of glioma-initiating cells by cell-penetrating D-isomer peptides consisting of Pas and the p53 C-terminus

  Yutaka Ueda; Fan-Yan Wei; Taku-ichiro Hide; Hiroyuki Michiue; Kentaro Takayama; Taku Kaitsuka; Hideo Nakamura; Keishi Makino; Jun-ichi Kuratsu; Shiroh Futaki; Kazuhito Tomizawa

  BIOMATERIALS, Dec. 2012, Peer-reviewed

  
• CXCR4 Stimulates Macropinocytosis: Implications for Cellular Uptake of Arginine-Rich Cell-Penetrating Peptides and HIV

  Gen Tanaka; Ikuhiko Nakase; Yasunori Fukuda; Ryo Masuda; Shinya Oishi; Kazuya Shimura; Yoshimasa Kawaguchi; Tomoka Takatani-Nakase; Ulo Langel; Astrid Graslund; Katsuya Okawa; Masao Matsuoka; Nobutaka Fujii; Yasumaru Hatanaka; Shiroh Futaki

  CHEMISTRY & BIOLOGY, Nov. 2012, Peer-reviewed

  
• Construction of a Rhythm Transfer System That Mimics the Cellular Clock

  Miki Imanishi; Kazutoshi Yamamoto; Hiroyuki Yamada; Yuka Hirose; Hitoshi Okamura; Shiroh Futaki

  ACS CHEMICAL BIOLOGY, Nov. 2012, Peer-reviewed

  
• Bioinspired Mechanism for the Translocation of Peptide through the Cell Membrane

  Kazutami Sakamoto; Kenichi Aburai; Taku Morishita; Kenichi Sakai; Hideki Sakai; Masahiko Abe; Ikuhiko Nakase; Shiroh Futaki

  CHEMISTRY LETTERS, Oct. 2012, Peer-reviewed

  
• Efficient Intracellular Delivery of Nucleic Acid Pharmaceuticals Using Cell-Penetrating Peptides

  Ikuhiko Nakase; Hidetaka Akita; Kentaro Kogure; Astrid Graslund; Ulo Langel; Hideyoshi Harashima; Shiroh Futaki

  ACCOUNTS OF CHEMICAL RESEARCH, Jul. 2012, Peer-reviewed

  
• Effect of the Attachment of a Penetration Accelerating Sequence and the Influence of Hydrophobicity on Octaarginine-Mediated Intracellular Delivery

  Kentaro Takayama; Hisaaki Hirose; Gen Tanaka; Silvia Pujals; Sayaka Katayama; Ikuhiko Nakase; Shiroh Futaki

  MOLECULAR PHARMACEUTICS, May 2012, Peer-reviewed

  
• Transient Focal Membrane Deformation Induced by Arginine-rich Peptides Leads to Their Direct Penetration into Cells

  Hisaaki Hirose; Toshihide Takeuchi; Hiroko Osakada; Silvia Pujals; Sayaka Katayama; Ikuhiko Nakase; Shouhei Kobayashi; Tokuko Haraguchi; Shiroh Futaki

  MOLECULAR THERAPY, May 2012, Peer-reviewed

  
• Accumulation of arginine-rich cell-penetrating peptides in tumors and the potential for anticancer drug delivery in vivo

  Ikuhiko Nakase; Yusuke Konishi; Masashi Ueda; Hideo Saji; Shiroh Futaki

  JOURNAL OF CONTROLLED RELEASE, Apr. 2012, Peer-reviewed

  
• Zn(II) Binding and DNA Binding Properties of Ligand-Substituted CXHH-Type Zinc Finger Proteins

  Miki Imanishi; Kazushi Matsumura; Shogo Tsuji; Tomohiro Nakaya; Shigeru Negi; Shiroh Futaki; Yukio Sugiura

  BIOCHEMISTRY, Apr. 2012, Peer-reviewed

  
• Rational design of DNA sequence-specific zinc fingers

  Hidetoshi Kono; Miki Imanishi; Shigeru Negi; Kazuya Tatsutani; Yui Sakaeda; Ayaka Hashimoto; Chie Nakayama; Shiroh Futaki; Yukio Sugiura

  FEBS LETTERS, Mar. 2012, Peer-reviewed

  
• Cell-Penetrating Peptide Induces Various Deformations of Lipid Bilayer Membrane: Inverted Micelle, Double Bilayer, and Transmembrane

  Shuhei Kawamoto; Takeshi Miyakawa; Masako Takasu; Ryota Morikawa; Tatsuki Oda; Hiroaki Saito; Shiroh Futaki; Hidemi Nagao

  INTERNATIONAL JOURNAL OF QUANTUM CHEMISTRY, Jan. 2012, Peer-reviewed

  
• Two-Dimensional Molecular Assembly of Bacteriochlorophyll a Derivatives Using Synthetic Poly(ethylene glycol)-Linked Light-Harvesting Model Polypeptides on a Gold Electrode Modified with Supported Lipid Bilayers

  Tsuyoshi Ochiai; Morio Nagata; Kosuke Shimoyama; Tomoya Kato; Takahide Asaoka; Masaharu Kondo; Takehisa Dewa; Keiji Yamashita; Ayumi Kashiwada; Shiroh Futaki; Hideki Hashimoto; Mamoru Nango

  ACS MACRO LETTERS, Jan. 2012, Peer-reviewed

  
• Signal Transduction Using an Artificial Receptor System that Undergoes Dimerization Upon Addition of a Bivalent Leucine-Zipper Ligand

  Ikuhiko Nakase; Shinya Okumura; Gen Tanaka; Katsuhiro Osaki; Miki Imanishi; Shiroh Futaki

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, Peer-reviewed

  
• Binding of Tat peptides on DOPC and DOPG lipid bilayer membrane studied by molecular dynamics simulations

  Shuhei Kawamoto; Masako Takasu; Takeshi Miyakawa; Ryota Morikawa; Tatsuki Oda; Shiroh Futaki; Hidemi Nagao

  MOLECULAR SIMULATION, 2012, Peer-reviewed

  
• Transformation of an antimicrobial peptide into a plasma membrane-permeable, mitochondria-targeted peptide via the substitution of lysine with arginine

  Ikuhiko Nakase; Shinya Okumura; Sayaka Katayama; Hisaaki Hirose; Silvia Pujals; Hirofumi Yamaguchi; Satoko Arakawa; Shigeomi Shimizu; Shiroh Futaki

  CHEMICAL COMMUNICATIONS, 2012, Peer-reviewed

  
• Dipicolylamine as a unique structural switching element for helical peptides

  Yusuke Azuma; Haruka Imai; Tomoyuki Yoshimura; Takeo Kawabata; Miki Imanishi; Shiroh Futaki

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, Peer-reviewed

  
• Free energy of cell-penetrating peptide through lipid bilayer membrane: coarse-grained model simulation

  S. Kawamoto; M. Takasu; T. Miyakawa; T. Oda; H. Saito; S. Futaki; H. Nagao; W. Shinoda

  Progress in Theoretical Chemistry and Physics, 2012, Peer-reviewed

  
• KALA-modified multi-layered nanoparticles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine

  Sharif M. Shaheen; Hidetaka Akita; Takashi Nakamura; Shota Takayama; Shiroh Futaki; Atsushi Yamashita; Ryo Katoono; Nobuhiko Yui; Hideyoshi Harashima

  BIOMATERIALS, Sep. 2011, Peer-reviewed

  
• KALA-modified multi-layered nanoparticles as gene carriers for MHC class-I mediated antigen presentation for a DNA vaccine

  Sharif M. Shaheen; Hidetaka Akita; Takashi Nakamura; Shota Takayama; Shiroh Futaki; Atsushi Yamashita; Ryo Katoono; Nobuhiko Yui; Hideyoshi Harashima

  Biomaterials, Sep. 2011, Peer-reviewed

  
• Octa-Arginine Mediated Delivery of Wild-Type Lnk Protein Inhibits TPO-Induced M-MOK Megakaryoblastic Leukemic Cell Growth by Promoting Apoptosis

  Chung Yeng Looi; Miki Imanishi; Satoshi Takaki; Miki Sato; Natsuko Chiba; Yoji Sasahara; Shiroh Futaki; Shigeru Tsuchiya; Satoru Kumaki

  PLOS ONE, Aug. 2011, Peer-reviewed

  
• Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA

  Yu Sakurai; Hiroto Hatakeyama; Yusuke Sato; Hidetaka Akita; Kentaro Takayama; Sachiko Kobayashi; Shiroh Futaki; Hideyoshi Harashima

  BIOMATERIALS, Aug. 2011, Peer-reviewed

  
• Internalization of Arginine-rich Cell-penetrating Peptides and Delivery of Biomacromolecules into Cells

  FUTAKI Shiroh

  MEMBRANE, 01 Jul. 2011

  
• An Arginine Residue Instead of a Conserved Leucine Residue in the Recognition Helix of the Finger 3 of Zif268 Stabilizes the Domain Structure and Mediates DNA Binding

  Shigeru Negi; Miki Imanishi; Maeko Sasaki; Kazuya Tatsutani; Shiroh Futaki; Yukio Sugiura

  BIOCHEMISTRY, Jul. 2011, Peer-reviewed

  
• Selective isolation of N-blocked peptide by combining AspN digestion, transamination, and tosylhydrazine glass treatment

  Kazuhiro Sonomura; Hiroki Kuyama; Ei-ichi Matsuo; Susumu Tsunasawa; Shiroh Futaki; Osamu Nishimura

  ANALYTICAL BIOCHEMISTRY, Mar. 2011, Peer-reviewed

  
• Inverted micelle formation of cell-penetrating peptide studied by coarse-grained simulation: Importance of attractive force between cell-penetrating peptides and lipid head group

  Shuhei Kawamoto; Masako Takasu; Takeshi Miyakawa; Ryota Morikawa; Tatsuki Oda; Shiroh Futaki; Hidemi Nagao

  JOURNAL OF CHEMICAL PHYSICS, Mar. 2011, Peer-reviewed

  
• Acylation of octaarginine: Implication to the use of intracellular delivery vectors

  Sayaka Katayama; Hisaaki Hirose; Kentaro Takayama; Ikuhiko Nakase; Shiroh Futaki

  JOURNAL OF CONTROLLED RELEASE, Jan. 2011, Peer-reviewed

  
• Reprint of: Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: Programmed endosomal escape and dissociation

  Hidetaka Akita; Kentaro Kogure; Rumiko Moriguchi; Yoshio Nakamura; Tomoko Higashi; Takashi Nakamura; Satoshi Serada; Minoru Fujimoto; Tetsuji Naka; Shiroh Futaki; Hideyoshi Harashima

  JOURNAL OF CONTROLLED RELEASE, Jan. 2011, Peer-reviewed

  
• Application of a fusiogenic peptide GALA for intracellular delivery.

  Nakase, I.; Kogure, K.; Harashima, H.; Futaki, S.

  Methods in molecular biology (Clifton, N.J.), 2011, Peer-reviewed

  
• Mechanisms of cellular uptake of cell-penetrating peptides

  Astrid Gräslund; Fatemeh Madani; Staffan Lindberg; Ülo Langel; Shiroh Futaki

  Journal of Biophysics, 2011, Peer-reviewed

  
• Control of Circadian Phase by an Artificial Zinc Finger Transcription Regulator

  Miki Imanishi; Atsushi Nakamura; Masao Doi; Shiroh Futaki; Hitoshi Okamura

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, Peer-reviewed

  
• The formation of particle-like structure on cell membranes accompanies direct influx of arginine-rich peptides into cells

  H. Hirose; T. Takeuchi; I. Nakase; S. Futaki

  BIOPOLYMERS, 2011, Peer-reviewed

  
• Switching mechanism of an optically-gated optical switch using an organic dye.

  Takashi Hiraga; Ichiro Ueno; Noriyasu Shiga; Hirofumi Watanabe; Shiroh Futaki; Masaki Kubo; Shigeru Takarada; Norio Tanaka

  ORGANIC PHOTONIC MATERIALS AND DEVICES XIII, 2011, Peer-reviewed

  
• Expressed protein ligation for the preparation of fusion proteins with cell penetrating peptides for endotoxin removal and intracellular delivery

  Hao-Hsin Yu; Ikuhiko Nakase; Silvia Pujals; Hisaaki Hirose; Gen Tanaka; Sayaka Katayama; Miki Imanishi; Shiroh Futaki

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Dec. 2010, Peer-reviewed

  
• Cytosolic delivery of macromolecules using pH-dependent fusogenic peptide

  Ikuhiko Nakase; Sachiko Kobayashi; Shiroh Futaki

  DRUG DISCOVERY TODAY, Dec. 2010, Peer-reviewed

  
• CHEMICAL AND BIOLOGICAL FACTORS THAT CONTRIBUTE TO THE INTERNALIZATION OF ARGININE-RICH CELL-PENETRATING PEPTIDES

  Shiroh Futaki

  JOURNAL OF GENE MEDICINE, Dec. 2010, Peer-reviewed

  
• Enhanced Target-Specific Accumulation of Radio labeled Antibodies by Conjugating Arginine-Rich Peptides as Anchoring Molecules

  Rei Miyamoto; Hiromichi Akizawa; Takeshi Nishikawa; Tomoya Uehara; Yusuke Azuma; Ikuhiko Nakase; Shiroh Futaki; Hirofumi Hanaoka; Yasuhiko Iida; Keigo Endo; Yasushi Arano

  BIOCONJUGATE CHEMISTRY, Nov. 2010, Peer-reviewed

  
• Zinc finger-zinc finger interaction between the transcription factors, GATA-1 and Sp1

  Miki Imanishi; Chika Imamura; Chika Higashi; Wei Yan; Shigeru Negi; Shiroh Futaki; Yukio Sugiura

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2010, Peer-reviewed

  
• Rev-derived peptides inhibit HIV-1 replication by antagonism of Rev and a co-receptor, CXCR4

  Kazuki Shimane; Eiichi N. Kodama; Ikuhiko Nakase; Shiroh Futaki; Yasuteru Sakurai; Yasuko Sakagami; Xiaoguang Li; Toshio Hattori; Stefan G. Sarafianos; Masao Matsuoka

  INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, Sep. 2010, Peer-reviewed

  
• Metal-Stimulated Regulation of Transcription by an Artificial Zinc-Finger Protein

  Miki Imanishi; Tomohiro Nakaya; Tatsuya Morisaki; Daisuke Noshiro; Shiroh Futaki; Yukio Sugiura

  CHEMBIOCHEM, Aug. 2010, Peer-reviewed

  
• Intracellular Delivery Using Membrane-Permeable Basic Peptides : The Molecular Mechanisms and Applications

  FUTAKI Shiroh; NAKASE Ikuhiko

  Seibutsu Butsuri, 25 May 2010, Peer-reviewed

  
• Nanoparticles for ex vivo siRNA delivery to dendritic cells for cancer vaccines: Programmed endosomal escape and dissociation

  Hidetaka Akita; Kentaro Kogure; Rumiko Moriguchi; Yoshio Nakamura; Tomoko Higashi; Takashi Nakamura; Satoshi Serada; Minoru Fujimoto; Tetsuji Naka; Shiroh Futaki; Hideyoshi Harashima

  JOURNAL OF CONTROLLED RELEASE, May 2010, Peer-reviewed

  
• Metal-Assisted Channel Stabilization: Disposition of a Single Histidine on the N-terminus of Alamethicin Yields Channels with Extraordinarily Long Lifetimes

  Daisuke Noshiro; Koji Asami; Shiroh Futaki

  BIOPHYSICAL JOURNAL, May 2010, Peer-reviewed

  
• Contribution of the flexible loop region to the function of staphylococcal enterotoxin B

  Saeko Yanaka; Motonori Kudou; Yoshikazu Tanaka; Takumi Sasaki; Sumiyo Takemoto; Atsuko Sakata; Yukio Hattori; Tomoyuki Koshi; Shiroh Futaki; Kouhei Tsumoto; Toshihiro Nakashima

  PROTEIN ENGINEERING DESIGN & SELECTION, May 2010, Peer-reviewed

  
• Cell-penetrating D-Isomer Peptides of p53 C-terminus: Long-term Inhibitory Effect on the Growth of Bladder Cancer

  Daiji Araki; Kentaro Takayama; Miyabi Inoue; Toyohiko Watanabe; Hiromi Kumon; Shiroh Futaki; Hideki Matsui; Kazuhito Tomizawa

  UROLOGY, Apr. 2010, Peer-reviewed

  
• Development of an intracellularly acting inhibitory peptide selective for PKN

  Kazuhiro Shiga; Kentaro Takayama; Shiroh Futaki; Jessica E. Hutti; Lewis C. Cantley; Katsuko Ueki; Yoshitaka Ono; Hideyuki Mukai

  BIOCHEMICAL JOURNAL, Jan. 2010, Peer-reviewed

  
• Artificial Transcription Factors Based on Multi-zinc Finger Motifs

  Tatsuya Morisaki; Miki Imanishi; Shiroh Futaki; Yukio Sugiura

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Jan. 2010, Peer-reviewed

  
• Binding of Tat peptides on DOPC and DOPG lipid bilayer membrane studied by molecular dynamics simulations

  KAWAMOTO, Shuhei; TALASU, Masako; MIYAKAWA, Takeshi; MORIKAWA, Ryota; ODA, Tatsuki; FUTAKI, Shiroh; NOGAO, Hidemi

  Molecular Simulation, DOI:10.1080/08927022.2010.536546,, 2010, Peer-reviewed

  
• Endosome-Disruptive Peptides for Improving Cytosolic Delivery of Bioactive Macromolecules

  Ikuhiko Nakase; Sachiko Kobayashi; Shiroh Futaki

  BIOPOLYMERS, 2010, Peer-reviewed

  
• Transduction of Cell-Penetrating Peptides Into Induced Pluripotent Stem Cells

  Hiroshi Yukawa; Hirofumi Noguchi; Ikuhiko Nakase; Yoshitaka Miyamoto; Koichi Oishi; Nobuyuki Hamajima; Shiroh Futaki; Shuji Hayashi

  CELL TRANSPLANTATION, 2010, Peer-reviewed

  
• Cellular uptake, distribution and cytotoxicity of the hydrophobic cell penetrating peptide sequence PFVYLI linked to the proapoptotic domain peptide PAD

  Catherine L. Watkins; Paul Brennan; Christopher Fegan; Kentaro Takayama; Ikuhiko Nakase; Shiroh Futaki; Arwyn T. Jones

  JOURNAL OF CONTROLLED RELEASE, Dec. 2009, Peer-reviewed

  
• Elucidating cell-penetrating peptide mechanisms of action for membrane interaction, cellular uptake, and translocation utilizing the hydrophobic counter-anion pyrenebutyrate

  Peter Guterstam; Fatemeh Madani; Hisaaki Hirose; Toshihide Takeuchi; Shiroh Futaki; Samir El Andaloussi; Astrid Graslund; Ulo Langel

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Dec. 2009, Peer-reviewed

  
• Elucidating cell-penetrating peptide mechanisms of action for membrane interaction, cellular uptake, and translocation utilizing the hydrophobic counter-anion pyrenebutyrate.

  Guterstam P; Madani F; Hirose H; Takeuchi T; Futaki S; El Andaloussi S; Gräslund A; Langel U

  Biochimica et biophysica acta, Dec. 2009, Peer-reviewed

  
• DYNAMICS IN CELLULAR UPTAKE OF ARGININE-RICH PEPTIDES

  Shiroh Futaki

  JOURNAL OF GENE MEDICINE, Dec. 2009, Peer-reviewed

  
• 身近な「ペプチド」：いのちの基本からくすりまで

  二木史朗

  海洋化学研究, 01 Nov. 2009

  
• Cell-surface Accumulation of Flock House Virus-derived Peptide Leads to Efficient Internalization via Macropinocytosis

  Ikuhiko Nakase; Hisaaki Hirose; Gen Tanaka; Akiko Tadokoro; Sachiko Kobayashi; Toshihide Takeuchi; Shiroh Futaki

  MOLECULAR THERAPY, Nov. 2009, Peer-reviewed

  
• A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo

  Hiroto Hatakeyama; Erika Ito; Hidetaka Akita; Motoi Oishi; Yukio Nagasaki; Shiroh Futaki; Hideyoshi Harashima

  JOURNAL OF CONTROLLED RELEASE, Oct. 2009, Peer-reviewed

  
• Positive and negative cooperativity of modularly assembled zinc fingers

  Miki Imanishi; Atsushi Nakamura; Tatsuya Morisaki; Shiroh Futaki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2009, Peer-reviewed

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• Enhanced intracellular delivery using arginine-rich peptides by the addition of penetration accelerating sequences (Pas)

  Kentaro Takayama; Ikuhiko Nakase; Hiroyuki Michiue; Toshihide Takeuchi; Kazuhito Tomizawa; Hideki Matsui; Shiroh Futaki

  JOURNAL OF CONTROLLED RELEASE, Sep. 2009, Peer-reviewed

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• Effect of Polyethyleneglycol Spacer on the Binding Properties of Nuclear Localization Signal-Modified Liposomes to Isolated Nucleus

  Dai Kurihara; Hidetaka Akita; Asako Kudo; Tomoya Masuda; Shiroh Futaki; Hideyoshi Harashima

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jul. 2009, Peer-reviewed

  
• Low concentration thresholds of plasma membranes for rapid energy-independent translocation of a cell-penetrating peptide

  Catherine L. Watkins; Dirk Schmaljohann; Shiroh Futaki; Arwyn T. Jones

  BIOCHEMICAL JOURNAL, Jun. 2009, Peer-reviewed

  
• Mesostructured silica based delivery system for a drug with a peptide as a cell-penetrating vector

  Chuanbo Gao; Isabel Izquierdo-Barba; Ikuhiko Nakase; Shiroh Futaki; Juanfang Ruan; Kazutami Sakamoto; Yasuhiro Sakamoto; Kazuyuki Kuroda; Osamu Terasaki; Shunai Che

  MICROPOROUS AND MESOPOROUS MATERIALS, Jun. 2009, Peer-reviewed

  
• Cytosolic Targeting of Macromolecules Using a pH-Dependent Fusogenic Peptide in Combination with Cationic Liposomes

  Sachiko Kobayashi; Ikuhiko Nakase; Noriko Kawabata; Hao-Hsin Yu; Silvia Pujals; Miki Imanishi; Ernest Giralt; Shiroh Futaki

  BIOCONJUGATE CHEMISTRY, May 2009, Peer-reviewed

  
• Efficient short interference rna delivery to tumor cells using a combination of octaarginine, gala and tumor-specific, cleavable polyethylene glycol system

  Yu Sakurai; Hiroto Hatakeyama; Hidetaka Akita; Motoi Oishi; Yukio Nagasaki; Shiroh Futaki; Hideyoshi Harashima

  Biological and Pharmaceutical Bulletin, May 2009, Peer-reviewed

  
• A pH-Sensitive Fusogenic Peptide Facilitates Endosomal Escape and Greatly Enhanced the Gene Silencing of siRNA-Containing Nanoparticles In Vitro and In Vivo

  Hiroto Hatakeyama; Erika Itho; Hidetaka Akita; Motoi Oihi; Yukio Nagasaki; Shiroh Futaki; Hideyoshi Harashima

  MOLECULAR THERAPY, May 2009, Peer-reviewed

  
• High-resolution multi-dimensional NMR spectroscopy of proteins in human cells

  Kohsuke Inomata; Ayako Ohno; Hidehito Tochio; Shin Isogai; Takeshi Tenno; Ikuhiko Nakase; Toshihide Takeuchi; Shiroh Futaki; Yutaka Ito; Hidekazu Hiroaki; Masahiro Shirakawa

  NATURE, Mar. 2009, Peer-reviewed

  
• Delivery of Macromolecules Using Arginine-Rich Cell-Penetrating Peptides: Ways to Overcome Endosomal Entrapment

  Ayman El-Sayed; Shiroh Futaki; Hideyoshi Harashima

  AAPS JOURNAL, Mar. 2009, Peer-reviewed

  
• Transferrin receptor-dependent cytotoxicity of artemisinin-transferrin conjugates on prostate cancer cells and induction of apoptosis

  Ikuhiko Nakase; Byron Gallis; Tornoka Takatani-Nakase; Steve Oh; Eric Lacoste; Narendra P. Singh; David R. Goodlett; Seigo Tanaka; Shiroh Futaki; Henry Lai; Tomikazu Sasaki

  CANCER LETTERS, Feb. 2009, Peer-reviewed

  
• Novel System to Achieve One-Pot Modification of Cargo Molecules with Oligoarginine Vectors for Intracellular Delivery

  Kentaro Takayama; Akiko Tadokoro; Silvia Pujals; Ikuhiko Nakase; Ernest Giralt; Shiroh Futaki

  BIOCONJUGATE CHEMISTRY, Feb. 2009, Peer-reviewed

  
• Development of membrane-permeable peptide vectors and their internalization mechanisms

  Dcuhiko Nakase; Shiroh Futaki

  Seikagaku, 2009, Peer-reviewed

  
• 「細胞表面を取り巻く化学」

  二木史朗

  化学レビュー１０ 生体機能化学生体機能の謎に迫る！, 64(3), 48-52, 2009

  
• 膜透過ペプチドベクターの開発とメカニズム (Review)

  中瀬生彦; 二木史朗

  生化学, 81（11）, 992-995, 2009, Peer-reviewed

  
• Cobalt(II)-Responsive DNA Binding of a GCN4-bZIP Protein Containing Cysteine Residues Functionalized with Iminodiacetic Acid

  Yusuke Azuma; Miki Imanishi; Tomoyuki Yoshimura; Takeo Kawabata; Shiroh Futaki

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, Peer-reviewed

  
• Oligoarginine-Based Prodrugs with Self-Cleavable Spacers for Caco-2 Cell Permeation

  Kentaro Takayama; Yuka Suehisa; Takuya Fujita; Jeffrey-Tri Nguyen; Shiroh Futaki; Akira Yamamoto; Yoshiaki Kiso; Yoshio Hayashi

  CHEMICAL & PHARMACEUTICAL BULLETIN, Nov. 2008, Peer-reviewed

  
• Oligoarginine-based prodrugs with self-cleavable spacers for intestinal absorption.

  Kentaro Takayama; Yuka Suehisa; Takuya Fujita; Jeffrey-Tri Nguyen; Shiroh Futaki; Akira Yamamoto; Yoshiaki Kiso; Yoshio Hayashi

  Chemical and Pharmaceuticsl Bulletin, Nov. 2008

  
• Rapid transcriptional activity in vivo and slow DNA binding in vitro by an artificial multi-zinc finger protein

  Tatsuya Morisaki; Miki Imanishi; Shiroh Futaki; Yukio Sugiura

  BIOCHEMISTRY, Sep. 2008, Peer-reviewed

  
• Octaarginine- and octalysine-modified nanoparticles have different modes of endosomal escape

  Ayman El-Sayed; Ikramy A. Khalil; Kentaro Kogure; Shiroh Futaki; Hideyoshi Harashima

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2008, Peer-reviewed

  
• An artificial virus-like nano carrier system: enhanced endosomal escape of nanoparticles via synergistic action of pH-sensitive fusogenic peptide derivatives

  Kentaro Sasaki; Kentaro Kogure; Shinji Chaki; Yoshio Nakamura; Rumiko Moriguchi; Hirofumi Hamada; Radostin Danev; Kuniaki Nagayama; Shiroh Futaki; Hideyoshi Harashima

  ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Aug. 2008, Peer-reviewed

  
• Novel intracellular delivery system using pH-dependent fusiogenic peptide

  Ikuhiko Nakase; Sachiko Kobayashi; Noriko Kawabata; Shiroh Futaki

  JOURNAL OF PEPTIDE SCIENCE, Aug. 2008, Peer-reviewed

  
• 膜透過ペプチドを用いる細胞導入技術

  二木史朗

  ファルマシア, 01 Apr. 2008, Peer-reviewed

  
• Octaarginine-modified liposomes: Enhanced cellular uptake and controlled intracellular trafficking

  Krarny A. Khalil; Kentaro Kogure; Shiroh Futaki; Hideyoshi Harashima

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Apr. 2008, Peer-reviewed

  
• Methodological and cellular aspects that govern the internalization mechanisms of arginine-rich cell-penetrating peptides

  Ikuhiko Nakase; Toshihide Takeuchi; Gen Tanaka; Shiroh Futaki

  ADVANCED DRUG DELIVERY REVIEWS, Mar. 2008, Peer-reviewed

  
• Membrane permeable peptide vectors: chemistry and functional design for the therapeutic applications - Preface

  Shiroh Futaki

  ADVANCED DRUG DELIVERY REVIEWS, Mar. 2008, Peer-reviewed

  
• Cellular internalization and distribution of arginine-rich peptides as a function of extracellular peptide concentration, serum, and plasma membrane associated proteoglycans

  Michie Kosuge; Toshihide Takeuchi; Ikuhiko Nakase; Arwyn Tomos Jones; Shiroh Futaki

  BIOCONJUGATE CHEMISTRY, Mar. 2008, Peer-reviewed

  
• Creation of metal sensitive channel-forming peptides: Metal-assisted peptide assembly and its application

  Daisuke Noshiro; Koji Asami; Shiroh Futaki

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2008, Peer-reviewed

  
• Structural switch of artificial metal-responsive leucine zipper motifs using Ida-Co(II) complexation

  Yusuke Azuma; Tomoyuki Yoshimura; Takeo Kawabata; Shiroh Futaki

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2008, Peer-reviewed

  
• Evaluation of effective membrane penetration by FHV peptide

  Ikuhiko Nakase; Hisaaki Hirose; Shiroh Futaki

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2008, Peer-reviewed

  
• Effect of surface-modification with octaarginine versus octalysine on cellular uptake and endosomal escape of nanoparticles

  Ayman El-Sayed; Ikramy A. Khalil; Kentaro Kogure; Shiroh Futaki; Hideyoshi Harashima

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2008, Peer-reviewed

  
• Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption

  Yoshio Hayashi; Kentaro Takayama; Yuka Suehisa; Takuya Fujita; Jeffrey-Tri Nguyen; Shiroh Futaki; Akira Yamamoto; Yoshiaki Kiso

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Sep. 2007, Peer-reviewed

  
• Arginine-rich peptides and their internalization mechanisms

  S. Futaki; I. Nakase; A. Taclokoro; T. Takeuchi; A. T. Jones

  BIOCHEMICAL SOCIETY TRANSACTIONS, Aug. 2007, Peer-reviewed

  
• alpha-helical linker of an artificial 6-zinc finger peptide contributes to selective DNA binding to a discontinuous recognition sequence

  Wei Yan; Miki Imanishi; Shiroh Futaki; Yukio Sugiura

  BIOCHEMISTRY, Jul. 2007, Peer-reviewed

  
• New packaging method of mycobacterial cell wall using octaarginine-modified liposomes: Enhanced uptake by and immunostimulatory activity of dendritic cells

  Atthachal Homhuan; Kentaro Kogure; Hideyuki Akaza; Shiroh Futaki; Takashi Naka; Yukiko Fujita; Ikuya Yano; Hideyoshi Harashima

  JOURNAL OF CONTROLLED RELEASE, Jul. 2007, Peer-reviewed

  
• Octaarginine-modified multifunctional envelope-type nano device for siRNA

  Yoshio Nakamura; Kentaro Kogure; Shiroh Futaki; Hideyoshi Harashima

  JOURNAL OF CONTROLLED RELEASE, Jun. 2007, Peer-reviewed

  
• Temperature-, concentration- and cholesterol-dependent translocation of L- and D-octa-arginine across the plasma and nuclear membrane of CD34(+) leukaemia cells

  Marjan M. Fretz; Neal A. Penning; Saly Al-Taei; Shiroh Futaki; Toshihide Takeuchi; Ikuhiko Nakase; Gert Storm; Arwyn T. Jones

  BIOCHEMICAL JOURNAL, Apr. 2007, Peer-reviewed

  
• NMR investigation of the electrostatic effect in binding of a neuropeptide, achatin-I, to phosphatidylcholine bilayers

  Tomohiro Kimura; Keiko Ninomiya; Shiroh Futaki

  JOURNAL OF PHYSICAL CHEMISTRY B, Apr. 2007, Peer-reviewed

  
• Octaarginine-modified multifunctional envelope-type nanoparticles for gene delivery

  I. A. Khalil; K. Kogure; S. Futaki; S. Hama; H. Akita; M. Ueno; H. Kishida; M. Kudoh; Y. Mishina; K. Kataoka; M. Yamada; H. Harashima

  GENE THERAPY, Apr. 2007, Peer-reviewed

  
• Activation of c-Jun NH2-terminal kinase (JNK) pathway during islet transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor

  H. Noguchi; Y. Nakai; M. Ueda; Y. Masui; S. Futaki; N. Kobayashi; S. Hayashi; S. Matsumoto

  DIABETOLOGIA, Mar. 2007, Peer-reviewed

  
• Interaction of arginine-rich peptides with membrane-associated proteoglycans is crucial for induction of actin organization and macropinocytosis

  Ikuhiko Nakase; Akiko Tadokoro; Noriko Kawabata; Toshihide Takeuchi; Hironori Katoh; Kiyo Hiramoto; Manabu Negishi; Motoyoshi Nomizu; Yukio Sugiura; Shiroh Futaki

  BIOCHEMISTRY, Jan. 2007, Peer-reviewed

  
• Guanidine-containing molecular transporters: Sorbitol-based transporters show high intracellular selectivity toward mitochondria

  Kaustabh K. Maiti; Woo Sirl Lee; Toshihide Takeuchi; Catherine Watkins; Marjan Fretz; Dong-Chan Kim; Shiroh Futaki; Arwyn Jones; Kyong-Tai Kim; Sung-Kee Chung

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, Peer-reviewed

  
• Ligand-induced extramembrane conformation switch controlling alamethicin assembly and the channel current

  Shiroh Futaki; Koji Asami

  CHEMISTRY & BIODIVERSITY, 2007, Peer-reviewed

  
• Acid wash in determining cellular uptake of fab/cell-permeating peptide conjugates

  Shouju Kameyama; Mayo Horie; Takeo Kikuchi; Takao Omura; Akiko Tadokoro; Toshihide Takeuchi; Ikuhiko Nakase; Yukio Sugiura; Shiroh Futaki

  BIOPOLYMERS, 2007, Peer-reviewed

  
• Oligomers of beta-amino acid bearing non-planar amides form ordered structures

  Yuko Otani; Shiroh Futaki; Tatsuto Kiwada; Yukio Sugiura; Atsuya Muranaka; Nagao Kobayashi; Masanobu Uchiyama; Kentaro Yamaguchi; Tomohiko Ohwada

  TETRAHEDRON, Dec. 2006, Peer-reviewed

  
• Effects of Na+/H+ exchanger inhibitors on subcellular localisation of endocytic organelles and intracellular dynamics of protein transduction domains HIV-TAT peptide and octaarginine

  Marjan Fretz; Jing Jin; Robin Conibere; Neal A. Penning; Saly Al-Taei; Gert Storm; Shiroh Futaki; Toshihide Takeuchi; Ikuhiko Nakase; Arwyn T. Jones

  JOURNAL OF CONTROLLED RELEASE, Nov. 2006, Peer-reviewed

  
• Anion hopping of (and on) functional oligoarginines: from chloroform to cells

  Naomi Sakai; Shiroh Futaki; Stefan Matile

  SOFT MATTER, Aug. 2006, Peer-reviewed

  
• Cellular uptake and subsequent intracellular trafficking of R8-liposomes introduced at low temperature

  Akitada Iwasa; Hidetaka Akita; Ikramy Khalil; Kentaro Kogure; Shiroh Futaki; Hideyoshi Harashima

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Jun. 2006, Peer-reviewed

  
• Delivery of condensed DNA by liposomal non-viral gene delivery system into nucleus of dendritic cells

  Takashi Nakamura; Rumiko Moriguchi; Kentaro Kogure; Arisa Minoura; Tomoya Masuda; Hidetaka Akita; Kazunori Kato; Hirofumi Hamada; Shiroh Futaki; Hideyoshi Harashima

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jun. 2006, Peer-reviewed

  
• Cellular uptake and subsequent intracellular trafficking of R8-liposomes introduced at low temperature.

  Akitada Iwasa; Hidetaka Akita; Ikramy Khalil; Kentaro Kogure; Shiroh Futaki; Hideyoshi Harashima

  Biochimica et biophysica acta, Jun. 2006

  
• ペプチドによる細胞内移送制御

  二木史朗

  高分子, 01 May 2006, Peer-reviewed

  
• Effects of cell-permeating peptide binding on the distribution of I-125-labeled Fab fragment in rats

  S Kameyama; M Horie; T Kikuchi; T Omura; T Takeuchi; Nakase, I; Y Sugiura; S Futaki

  BIOCONJUGATE CHEMISTRY, May 2006, Peer-reviewed

  
• Transmission of extramembrane conformational change into current: Construction of metal-gated ion channel

  T Kiwada; K Sonomura; Y Sugiura; K Asami; S Futaki

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, May 2006, Peer-reviewed

  
• Significant Silencing Effect of a Multifunctional Envelope-Type Nano Device Encapsulating Antisense Oligodeoxynucleotide and Double-Stranded siRNA

  Kentaro Kogure; Yoshio Nakamura; Ikramy A. Khalil; Shiroh Futaki; Hideyoshi Harashima

  MOLECULAR THERAPY, May 2006, Peer-reviewed

  
• Cellular Uptake and Subsequent Intracellular of R8-Liposomes Introduced at Low Temperature

  Akitada Iwasa; Hidetaka Akita; Ikramy Khalil; Kentaro Kogure; Shiroh Futaki; Hideyoshi Harashima

  MOLECULAR THERAPY, May 2006, Peer-reviewed

  
• Significant and prolonged antisense effect of a multifunctional envelope-type nano device encapsulating antisense oligodeoxynucleotide

  Y Nakamura; K Kogure; Y Yamada; S Futaki; H Harashima

  JOURNAL OF PHARMACY AND PHARMACOLOGY, Apr. 2006, Peer-reviewed

  
• Distribution of immunoglobulin Fab fragment conjugated with HIV-1 REV peptide following intravenous administration in rats

  Shouju Kameyama; Ritsuko Okada; Takeo Kikuchi; Takao Ornura; Ikuhiko Nakase; Toshihide Takeuchi; Yukio Sugiura; Shiroh Futaki

  MOLECULAR PHARMACEUTICS, Mar. 2006, Peer-reviewed

  
• High density of octaarginine stimulates macropinocytosis leading to efficient intracellular trafficking for gene expression

  IA Khalil; K Kogure; S Futaki; H Harashima

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2006, Peer-reviewed

  
• Evaluation of the nuclear delivery and intra-nuclear transcription of plasmid DNA condensed with mu (mu) and NLS-mu by cytoplasmic and nuclear microinjection: a comparative study with poly-L-lysine

  H Akita; M Tanimoto; T Masuda; K Kogure; S Hama; K Ninomiya; S Futaki; H Harashima

  JOURNAL OF GENE MEDICINE, Feb. 2006, Peer-reviewed

  
• Design of Intracellular Delivery Using Peptide Vectors

  Futaki Shiroh

  Kobunshi, 01 Jan. 2006

  
• Intracellular traffic and fate of protein transduction domains HIV-1 TAT peptide and octaarginine. Implications for their utilization as drug delivery vectors

  S Al-Taei; NA Penning; JC Simpson; S Futaki; T Takeuchi; Nakase, I; AT Jones

  BIOCONJUGATE CHEMISTRY, Jan. 2006, Peer-reviewed

  
• トピックス：ペプチドベクターを用いた細胞内移送

  二木史朗

  酵素工学ニュース第５５号, 平成18年4月号, 41497, 2006

  
• 分子集合体の細胞内デリバリー

  二木史朗

  臨床検査, 50, 1439-1546, 2006, Peer-reviewed

  
• Design, synthesis, and membrane-translocation studies of inositol-based transporters

  Kaustabh K. Maiti; Ock-Youm Jeon; Woo Sirl Lee; Dong-Chan Kim; Kyong-Tai Kim; Toshihide Takeuchi; Shiroh Futaki; Sung-Kee Chung

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, Peer-reviewed

  
• Direct and rapid cytosolic delivery using cell-penetrating peptides mediated by pyrenebutyrate

  Toshihide Takeuchi; Michie Kosuge; Akiko Tadokoro; Yukio Sugiura; Mayumi Nishi; Mitsuhiro Kawata; Naomi Sakai; Stefan Matile; Shiroh Futaki

  ACS CHEMICAL BIOLOGY, 2006, Peer-reviewed

  
• Oligoarginine vectors for intracellular delivery: Design and cellular-uptake mechanisms

  S Futaki

  BIOPOLYMERS, 2006, Peer-reviewed

  
• Direct and rapid cytosolic delivery using cell-penetrating peptides in the presence of counteranions.

  Takeuchi T; Kosuge M; Tadokoro A; Sugiura Y; Nishi M; Kawata M; Sakai N; Matile S; Futaki S

  ACS Chemical Biology, 2006, Peer-reviewed

  
• Unique features of a pH-sensitive fusogenic peptide that improves the transfection efficiency of cationic liposomes

  S Futaki; Y Masui; Nakase, I; Y Sugiura; T Nakamura; K Kogure; H Harashima

  JOURNAL OF GENE MEDICINE, Nov. 2005, Peer-reviewed

  
• Intracellular Protein Delivery Using Membrane-Permeable Peptides

  FUTAKI Shiroh

  KAGAKU TO SEIBUTSU, 01 Oct. 2005

  
• Mitochondrial delivery of mastoparan with transferrin liposornes equipped with a pH-sensitive fusogenic peptide for selective cancer therapy

  Y Yamada; Y Shinohara; T Kakudo; S Chaki; S Futaki; H Kamiya; H Harashima

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Oct. 2005, Peer-reviewed

  
• A multifunctional envelope-type nano device for novel gene delivery of siRNA plasmids

  R Moriguchi; K Kogure; H Akita; S Futaki; M Miyagishi; K Taira; H Harashima

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Sep. 2005, Peer-reviewed

  
• Cell permeable peptide of JNK inhibitor prevents islet apoptosis immediately after isolation and improves islet graft function

  H Noguchi; Y Nakai; S Matsumoto; M Kawaguchi; M Ueda; T Okitsu; Y Iwanaga; Y Yonekawa; H Nagata; K Minami; Y Masui; S Futaki; K Tanaka

  AMERICAN JOURNAL OF TRANSPLANTATION, Aug. 2005, Peer-reviewed

  
• Real-time in-cell F-19 NMR study on uptake of fluorescent and nonfluorescent F-19-octaarginines into human Jurkat cells

  E Okamura; K Ninomiya; S Futaki; Y Nagai; T Kimura; C Wakai; N Matubayasi; Y Sugiura; M Nakahara

  CHEMISTRY LETTERS, Jul. 2005, Peer-reviewed

  
• Site-specific DNA cleavage by artificial zinc finger-type nuclease with cerium-binding peptide

  T Nakatsukasa; Y Shiraishi; S Negi; M Imanishi; S Futaki; Y Sugiura

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2005, Peer-reviewed

  
• RNase S complex bearing arginine-rich peptide and anti-HIV activity

  S Futaki; Nakase, I; T Suzuki; D Nameki; EI Kodama; M Matsuoka; Y Sugiura

  JOURNAL OF MOLECULAR RECOGNITION, Mar. 2005, Peer-reviewed

  
• Anionic fullerenes, calixarenes, coronenes, and pyrenes as activators of oligo/polyarginines in model membranes and live cells

  F Perret; M Nishihara; T Takeuchi; S Futaki; AN Lazar; AW Coleman; N Sakai; S Matile

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2005, Peer-reviewed

  
• Membrane-permeable arginine-rich peptides and the translocation mechanisms

  S Futaki

  ADVANCED DRUG DELIVERY REVIEWS, Feb. 2005, Peer-reviewed

  
• Direct observation of anion-mediated translocation of fluorescent oligoarginine carriers into and across bulk liquid and anionic bilayer membranes

  N Sakai; T Takeuchi; S Futaki; S Matile

  CHEMBIOCHEM, Jan. 2005, Peer-reviewed

  
• Arginine magic with new counterions up the sleeve

  M Nishihara; F Perret; T Takeuchi; S Futaki; AN Lazar; AW Coleman; N Sakai; S Matile

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2005, Peer-reviewed

  
• PDX-1 protein is internalized by lipid raft-dependent macropinocytosis

  H Noguchi; S Matsumoto; T Okitsu; Y Iwanaga; Y Yonekawa; H Nagata; M Matsushita; FY Wei; H Matsui; K Minami; S Seino; Y Masui; S Futaki; K Tanaka

  CELL TRANSPLANTATION, 2005, Peer-reviewed

  
• Pharmacokinetic analysis of the tissue distribution of octaarginine modified liposomes in mice.

  D. Mudhakir; H. Akita; I.A. Khalil; S. Futaki; H. Harashima

  Drug metabolism and pharmacokinetics., 2005, Peer-reviewed

  
• Intracellular delivery of arginine-rich peptides using counteranions

  T Takeuchi; M Kosuge; A Tadokoro; Y Sugiura; N Sakai; S Matile; S Futaki

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2005, Peer-reviewed

  
• Octaarginine-mediated stimulation of clathrin-independent endocytic uptake leading to enhanced gene expression through avoiding lysosomal degradation

  IA Khalil; K Kogure; S Futaki; H Harashima

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2005, Peer-reviewed

  
• Arginine-rich peptides: the structures and manners of internalization

  Shiroh Futaki; Ikuhiko Nakase; Toshihide Takeuchi; Miki Niwa; Jeremy C. Simpson; Arwyn T. Jones; Yukio Sugiura

  Peptides 2004, Proceedings, 2005, Peer-reviewed

  
• Control of peptide structure and recognition by Fe(III)-induced helix destabilization

  S Futaki; T Kiwada; Y Sugiura

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2004, Peer-reviewed

  
• Cellular uptake of arginine-rich peptides: Roles for macropinocytosis and actin rearrangement

  Nakase, I; M Niwa; T Takeuchi; K Sonomura; N Kawabata; Y Koike; M Takehashi; S Tanaka; K Ueda; JC Simpson; AT Jones; Y Sugiura; S Futaki

  MOLECULAR THERAPY, Dec. 2004, Peer-reviewed

  
• アルギニンペプチドを用いたタンパク質および薬物の細胞内送達

  中瀬生彦; 二木史朗

  化学, 01 Nov. 2004

  
• ＤＤＳの新しい潮流（２）ペプチドを用いた細胞内デリバリー

  二木史朗

  Drug Metab Pharmacokinet, 30 Aug. 2004

  
• キャリヤーペプチドを使ってタンパク質やさまざまな分子を細胞に導入できる！

  二木史朗

  現代化学, 01 Aug. 2004

  
• Development of a non-viral multifunctional envelope-type nano device by a novel lipid film hydration method

  K Kogure; R Moriguchi; K Sasaki; M Ueno; S Futaki; H Harashima

  JOURNAL OF CONTROLLED RELEASE, Aug. 2004, Peer-reviewed

  
• Intracellular Delivery Using Arginine-Rich Peptides

  FUTAKI Shiroh

  薬剤学, 01 May 2004

  
• Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: An artificial viral-like delivery system

  T Kakudo; S Chaki; S Futaki; Nakase, I; K Akaji; T Kawakami; K Maruyama; H Kamiya; H Harashima

  BIOCHEMISTRY, May 2004, Peer-reviewed

  
• Arginine carrier peptide bearing Ni(II) chelator to promote cellular uptake of histidine-tagged proteins

  S Futaki; M Niwa; Nakase, I; A Tadokoro; YJ Zhang; M Nagaoka; N Wakako; Y Sugiura

  BIOCONJUGATE CHEMISTRY, May 2004, Peer-reviewed

  
• Mechanism of improved gene transfer by the N-terminal stearylation of octaarginine: enhanced cellular association by hydrophobic core formation

  IA Khalil; S Futaki; M Niwa; Y Baba; N Kaji; H Kamiya; H Harashima

  GENE THERAPY, Apr. 2004, Peer-reviewed

  
• Gramicidin-based channel systems for the detection of protein-ligand interaction

  S Futaki; YJ Zhang; T Kiwada; Nakase, I; T Yagami; S Oiki; Y Sugiura

  BIOORGANIC & MEDICINAL CHEMISTRY, Mar. 2004, Peer-reviewed

  
• Quantitative three-dimensional analysis of the intracellular trafficking of plasmid DNA transfected by a nonviral gene delivery system using confocal laser scanning microscopy

  H Akita; R Ito; IA Khalil; S Futaki; H Harashima

  MOLECULAR THERAPY, Mar. 2004, Peer-reviewed

  
• alpha,alpha-disubstituted glycines bearing a large hydrocarbon ring: Peptide self-assembly through hydrophobic recognition

  T Ohwada; D Kojima; T Kiwada; S Futaki; Y Sugiura; K Yamaguchi; Y Nishi; Y Kobayashili

  CHEMISTRY-A EUROPEAN JOURNAL, Feb. 2004, Peer-reviewed

  
• Total chemical synthesis of large CCK isoforms using a thioester segment condensation approach

  K Kitagawa; H Adachi; Y Sekigawa; T Yagami; S Futaki; YJ Gu; K Inoue

  TETRAHEDRON, Jan. 2004, Peer-reviewed

  
• Intracellular Delivery of Proteins and Drugs Using Arginine Peptides

  Nakase I; Futaki S

  Chemistry, Nov, 68-69, 2004

  
• Intracellular Delivery of Proteins and Macromolecules Using Carrier Peptides

  Futaki S

  Chemistry Today, Aug, 32-36, 2004

  
• Peptide-mediated Drug Delivery (Review)

  Futaki S

  The Cell, 36, 428-431, 2004

  
• ペプチドによるドラッグデリバリー (Review)

  二木史朗

  細胞, 36, 428-431, 2004

  
• Intracellular Delivery Using Arginine Peptides (Review)

  Futaki S

  J. Phar. Sci. Tech., Jpn, 64, 164-167, 2004

  
• Total synthesis of artificial zinc-finger proteins: Problems and perspectives

  S Futaki; K Tatsuto; Y Shiraishi; Y Sugiura

  BIOPOLYMERS, 2004, Peer-reviewed

  
• Factors affecting membrane transport of octaarginine-modified liposomes for gene delivery

  LA Khalil; K Kogure; S Futaki; H Harashima

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2004, Peer-reviewed

  
• Application of oligoarginine for the delivery of protein complexes into living cells

  Shiroh Futaki; Ikuhiko Nakase; Miki Niwa; Tomoki Suzuki; Daisuke Nameki; Ei-ichi Kodama; Masao Matsuoka; Yukio Sugiura

  Peptide Revolution: Genomics, Proteomics & Therapeutics, 2004, Peer-reviewed

  
• Synthetic copoly(Lys/Phe) and poly(Lys) translocate through lipid bilayer membranes.

  Akira Shibata; Syuichi Murata; Satoru Ueno; Shaoqian Liu; Shiroh Futaki; Yoshinobu Baba

  Biochimica et biophysica acta, 13 Oct. 2003, Peer-reviewed

  
• Synthetic copoly(Lys/Phe) and poly(Lys) translocate through lipid bilayer membranes

  A Shibata; S Murata; S Ueno; SQ Liu; S Futaki; Y Baba

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Oct. 2003, Peer-reviewed

  
• Membrane permeability commonly shared among arginine-rich peptides

  S Futaki; S Goto; Y Sugiura

  JOURNAL OF MOLECULAR RECOGNITION, Sep. 2003, Peer-reviewed

  
• Structural variety of membrane permeable peptides

  S Futaki; S Goto; T Suzuki; Nakase, I; Y Sugiura

  CURRENT PROTEIN & PEPTIDE SCIENCE, Apr. 2003, Peer-reviewed

  
• Can nuclear localization signals enhance nuclear localization of plasmid DNA?

  T Nagasaki; T Myohoji; T Tachibana; S Futaki; S Tamagaki

  BIOCONJUGATE CHEMISTRY, Mar. 2003, Peer-reviewed

  
• Preface

  Futaki, S.

  Current Protein and Peptide Science, 2003, Peer-reviewed

  
• pH-sensitive liposomes in nuclear targeting of macromolecules

  R Tachibana; S Futaki; H Harashima; H Kiwada

  LIPOSOMES, PT B, 2003, Peer-reviewed

  
• Intracellular delivery of biopolymers using membrane-permeable peptides.

  Futaki Shiroh

  MEMBRANE, 2003

  
• Arginine-rich peptides: potential for intracellular delivery of macromolecules and the mystery of the translocation mechanisms

  S Futaki

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Oct. 2002, Peer-reviewed

  
• Membrane permeable basic peptides: The potential of these peptides for the intracellular delivery of proteins and drugs.

  二木史朗

  蛋白質 核酸 酵素, 01 Sep. 2002, Peer-reviewed

  
• Detection of protein-ligand interaction on the membranes using C-terminus biotin-tagged alamethicin

  Y Zhang; S Futaki; T Kiwada; Y Sugiura

  BIOORGANIC & MEDICINAL CHEMISTRY, Aug. 2002, Peer-reviewed

  
• Generation of reactive oxygen species and activation of NF-kappa B by non-A beta component of Alzheimer's disease amyloid

  S Tanaka; M Takehashi; N Matoh; S Iida; T Suzuki; S Futaki; H Hamada; E Masliah; Y Sugiura; K Ueda

  JOURNAL OF NEUROCHEMISTRY, Jul. 2002, Peer-reviewed

  
• Translocation of branched-chain arginine peptides through cell membranes: Flexibility in the spatial disposition of positive charges in membrane-permeable peptides

  S Futaki; Nakase, I; T Suzuki; YJ Zhang; Y Sugiura

  BIOCHEMISTRY, Jun. 2002, Peer-reviewed

  
• コンビナトリアル・バイオエンジニアリング （６） バイオテクノロジーのニューウェーブ コンビナトリアル・バイオエンジニアリングの向かう未来

  民谷栄一; 二木史朗; 吉田和哉

  現代化学, 01 Mar. 2002, Peer-reviewed

  
• Kinetic analysis of the interaction between vitronectin and the urokinase receptor

  Y Okumura; Y Kamikubo; SA Curriden; JY Wang; T Kiwada; S Futaki; K Kitagawa; DJ Loskutoff

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2002, Peer-reviewed

  
• Topological stability and self-association of a completely hydrophobic model transmembrane helix in lipid bilayers

  Y Yano; T Takemoto; S Kobayashi; H Yasui; H Sakurai; W Ohashi; M Niwa; S Futaki; Y Sugiura; K Matsuzaki

  BIOCHEMISTRY, Mar. 2002, Peer-reviewed

  
• Possible existence of common internalization mechanisms among arginine-rich peptides

  T Suzuki; S Futaki; M Niwa; S Tanaka; K Ueda; Y Sugiura

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2002, Peer-reviewed

  
• Future of combinatorial Bioengineering

  Tamiya E; Futaki S; Yoshida K

  Chemistry Today, 372, 23-30, 2002, Peer-reviewed

  
• Membrane permeable basic peptides: the potential of these peptides for the intracellular delivery of proteins and drugs

  Futaki, S.

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2002, Peer-reviewed

  
• Alamethicin-leucine zipper hybrid peptide: A prototype for the design of artificial receptors and ion channels

  S Futaki; M Fukuda; M Omote; K Yamauchi; T Yagami; M Niwa; Y Sugiura

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2001, Peer-reviewed

  
• Stearylated arginine-rich peptides: A new class of transfection systems

  S Futaki; W Ohashi; T Suzuki; M Niwa; S Tanaka; K Ueda; H Harashima; Y Sugiura

  BIOCONJUGATE CHEMISTRY, Nov. 2001, Peer-reviewed

  
• Facile solid-phase synthesis of sulfated tyrosine-containing peptides: Part II. Total synthesis of human big Gastrin-II and its C-terminal glycine-extended peptide (G34-Gly sulfate) by the solid-phase segment condensation approach

  K Kitagawa; C Aida; H Fujiwara; T Yagami; S Futaki

  CHEMICAL & PHARMACEUTICAL BULLETIN, Aug. 2001, Peer-reviewed

  
• A 'cassette' RNase: Site-selective cleavage of RNA by RNase S equipped with RNA-recognition segment

  S Futaki; M Araki; T Kiwada; Nakase, I; Y Sugiura

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, May 2001, Peer-reviewed

  
• Evaluation of two sperm antigens, rSMP-B and YWK-II, as targets for immunocontraception

  M Takikawa; M Kamada; M Maegawa; S Yamano; M Irahara; T Aono; S Futaki; Y Ohmoto; SS Koide

  ZYGOTE, May 2001, Peer-reviewed

  
• Stoichiometry of subunit e in rat liver mitochondrial H+-ATP synthase and membrane topology of its putative Ca2+-dependent regulatory region

  N Arakaki; Y Ueyama; M Hirose; T Himeda; H Shibata; S Futaki; K Kitagawa; T Higuti

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, Apr. 2001, Peer-reviewed

  
• Arginine-rich peptides - An abundant source of membrane-permeable peptides having potential as carriers for intracellular protein delivery

  S Futaki; T Suzuki; W Ohashi; T Yagami; S Tanaka; K Ueda; Y Sugiura

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2001, Peer-reviewed

  
• Detecting a tag on a channel opening: blockage of the biotinylated channels by streptavidin

  S Futaki; YJ Zhang; Y Sugiura

  TETRAHEDRON LETTERS, Feb. 2001, Peer-reviewed

  
• Facile solid-phase synthesis of sulfated tyrosine-containing peptides: Total synthesis of human big gastrin-II and cholecystokinin (CCK)-39(1,2)

  K Kitagawa; C Aida; H Fujiwara; T Yagami; S Futaki; M Kogire; J Ida; K Inoue

  JOURNAL OF ORGANIC CHEMISTRY, Jan. 2001, Peer-reviewed

  
• チャネルポアの微細加工とリアルタイムセンシング

  二木史朗

  化学, 3月号, 58-59, 2001

  
• Specific cytotoxicity of antibody to YAL-198, a sperm antigen peptide, to murine zygote

  M. Kamada; M. Takikawa; M. Maegawa; S. Yamamoto; S. Yamanoa; M. Irahara; T. Aono; S. Futaki; Y. Ohmoto; S. Koide

  Systems Biology in Reproductive Medicine, 2001, Peer-reviewed

  
• Stabilization of a tyrosine O-sulfate residue by a cationic functional group: formation of a conjugate acid-base pair

  T Yagami; K Kitagawa; C Aida; H Fujiwara; S Futaki

  JOURNAL OF PEPTIDE RESEARCH, Oct. 2000, Peer-reviewed

  
• Artificial zinc finger peptide containing a novel His(4) domain

  Y Hori; K Suzuki; Y Okuno; M Nagaoka; S Futaki; Y Sugiura

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2000, Peer-reviewed

  
• Poly-(L)-glutamine forms cation channels: Relevance to the pathogenesis of the polyglutamine diseases

  H Monoi; S Futaki; S Kugimiya; H Minakata; K Yoshihara

  BIOPHYSICAL JOURNAL, Jun. 2000, Peer-reviewed

  
• シャペロンとして働く両親媒性高分子

  二木 史朗

  ファルマシア, 01 May 2000

  
• Stability and self aggregation of a model transmembrane helix in lipid bilayers

  Yano Y.; Takemoto T.; Kobayashi S; Ohashi W.; Niwa M.; Futaki S.; Sugiura Y.; Matsuzaki K.

  Seibutsu Butsuri, 2000

  
• Poly-L-glutamine forms cation channels: Relevance to the pathogenesis of the polyglutamine diseases

  Hiroshi Monoi; Shiroh Futaki; Shin-Ichi Kugimiya; Hiroyuki Minakata; Kazuo Yoshihara

  Biophysical Journal, 2000

  
• Identification of the human sperm protein that interacts with sperm-immobilizing antibodies in the sera of infertile women

  M Kamada; S Yamamoto; M Takikawa; K Kunimi; M Maegawa; S Futaki; Y Ohmoto; T Aono; SS Koide

  FERTILITY AND STERILITY, Oct. 1999, Peer-reviewed

  
• Fmoc固相合成法による硫酸化チロシン含有ペプチドの直接合成法の開発

  二木史朗; 北川幸己; 矢上 健; 山口 実

  島津評論, Aug. 1999

  
• Chemical ligation to obtain proteins comprising helices with individual amino acid sequences

  S Futaki; M Aoki; T Ishikawa; F Kondo; T Asahara; M Niwa; Y Nakaya; T Yagami; K Kitagawa

  BIOORGANIC & MEDICINAL CHEMISTRY, Jan. 1999, Peer-reviewed

  
• Stabilization of tyrosine-O-sulfate residues through the formation of a conjugate acid-base pair

  T Yagami; K Kitagawa; C Aida; H Fujiwara; S Futaki

  PEPTIDE SCIENCE - PRESENT AND FUTURE, 1999, Peer-reviewed

  
• Incorporation of the nuclear localization signal (NLS) peptide-albumin conjugate to macrophages using pH-sensitive liposomes

  S Futaki; R Tachibana; M Shono; M Azumano; M Niwa; H Kiwada; H Harashima

  PEPTIDE SCIENCE - PRESENT AND FUTURE, 1999, Peer-reviewed

  
• Desulfation vs. deprotection: direct solid-phase synthesis of Tyr(SO3H)-containing peptides using the SN1-type deprotection procedure

  K Kitagawa; T Yagami; C Aida; H Fujiwara; S Futaki; M Kogire; J Ida; K Inoue

  PEPTIDE SCIENCE - PRESENT AND FUTURE, 1999, Peer-reviewed

  
• Preparation of peptide thioester segments using Fmoc-solid-phase peptide synthesis and application of the thioester ligation strategy to the construction of TASP molecules

  S Futaki; K Sogawa; M Fukuda; M Niwa; H Hojo

  PEPTIDES: FRONTIERS OF PEPTIDES SCIENCE, 1999, Peer-reviewed

  
• Total solid-phase synthesis of human cholecystokinin (CCK)-39

  K Kitagawa; C Aida; H Fujiwara; T Yagami; S Futaki

  PEPTIDES: FRONTIERS OF PEPTIDES SCIENCE, 1999, Peer-reviewed

  
• The alamethicin-leucine zipper hybrid peptide: modulation of the assembling of transmembrane peptides through the extramembrane peptide segments

  S Futaki; M Fukuda; M Niwa

  PEPTIDE SCIENCE - PRESENT AND FUTURE, 1999, Peer-reviewed

  
• Peptide synthesis aiming at elucidation and creation of protein functions

  S Futaki

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Nov. 1998, Peer-reviewed

  
• Intracellular regulation of macromolecules using pH-sensitive liposomes and nuclear localization signal: Qualitative and quantitative evaluation of intracellular trafficking

  R Tachibana; H Harashima; M Shono; M Azumano; M Niwa; S Futaki; H Kiwada

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 1998, Peer-reviewed

  
• beta-Microseminoprotein prostatic secretory protein is a member of immunoglobulin binding factor family

  M Kamada; H Mori; N Maeda; S Yamamoto; K Kunimi; M Takikawa; M Maegawa; T Aono; S Futaki; SS Koide

  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, Oct. 1998, Peer-reviewed

  
• Enzymatic activation of immunoglobulin binding factor in female reproductive tract

  H Mori; M Kamada; M Maegawa; S Yamamoto; T Aono; S Futaki; M Yano; H Kido; SS Koide

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 1998, Peer-reviewed

  
• Creation of ion channel function using synthetic peptides

  S Futaki

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Feb. 1998, Peer-reviewed

  
• Involvement of H2O2 production in cisplatin-induced nephrotoxicity

  Y Tsutsumishita; T Onda; K Okada; M Takeda; H Endou; S Futaki; M Niwa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 1998, Peer-reviewed

  
• Peptide ion channels: Design and creation of function

  S Futaki

  BIOPOLYMERS, 1998, Peer-reviewed

  
• Synthesis and antinociceptive activity of [D-Ala(2)]Leu-enkephalin derivatives conjugated with the adamantane moiety

  K Kitagawa; N Mizobuchi; T Hama; T Hibi; R Konishi; S Futaki

  CHEMICAL & PHARMACEUTICAL BULLETIN, Nov. 1997, Peer-reviewed

  
• Benzoquinones inhibit the expression of inducible nitric oxide synthase gene

  M Niwa; N Nakamura; K Kitajima; M Ueda; Y Tsutsumishita; S Futaki; Y Takaishi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 1997, Peer-reviewed

  
• Assembling of the four individual helices corresponding to the transmembrane segments (S4 in repeat I-IV) of the sodium channel

  S Futaki; M Aoki; M Fukuda; F Kondo; M Niwa; K Kitagawa; Y Nakaya

  TETRAHEDRON LETTERS, Oct. 1997, Peer-reviewed

  
• Preparation of peptide thioesters using Fmoc-solid-phase peptide synthesis and its application to the construction of a template-assembled synthetic protein (TASP)

  S Futaki; K Sogawa; J Maruyama; T Asahara; M Niwa; H Hojo

  TETRAHEDRON LETTERS, Sep. 1997, Peer-reviewed

  
• Embodying a stable alpha-helical protein structure through efficient chemical ligation via thioether formation

  S Futaki; T Ishikawa; M Niwa; K Kitagawa; T Yagami

  BIOORGANIC & MEDICINAL CHEMISTRY, Sep. 1997, Peer-reviewed

  
• Benzoquinones inhibit inducible nitric oxide synthase mRNA expression

  M Niwa; K Kitajima; N Nakamira; S Futaki

  FASEB JOURNAL, Jul. 1997, Peer-reviewed

  
• Peptide-unit assembling via disulfide cross-linking: A versatile approach which enables the creation of artificial proteins comprising helices with different amino acid sequences

  S Futaki; K Kitagawa

  TETRAHEDRON, Jun. 1997, Peer-reviewed

  
• The structure of the promoter region for rat inducible nitric oxide synthase gene

  M Niwa; Y Kawai; N Nakamura; S Futaki

  LIFE SCIENCES, Jun. 1997, Peer-reviewed

  
• Efficient solid-phase synthesis of sulfated tyrosine-containing peptides using 2-chlorotrityl resin: Facile synthesis of gastrin/cholecystokinin peptides

  K Kitagawa; C Aida; H Fujiwara; T Yagami; S Futaki

  TETRAHEDRON LETTERS, Jan. 1997, Peer-reviewed

  
• Detection of A Speciflc Anti Sperm Antibody in Sera of Infertile Women

  K. Kunimi; M. Takikawa; S. Yamamoto; M Hirano; H. Mori; M. Maegawa; M. Kamada; T. Aono; S. Futaki; S. S. Koide

  Nihon Seishokumeneki Gakkai Zassi, 1997

  
• Expression of immunoglobulin binding factor mRNA in uterine cervical gland

  K. Kunimi; M. Takikawa; S. Yamamoto; H. Mori; M. Maegawa; M. Kamada; T. Aono; S. Futaki; M. Niwa; S. S. Koide

  Journal of Reproductive Immunology, 1997, Peer-reviewed

  
• Expression of immunoglobulin binding factor mRNA in uterine cervical gland

  S. Yamamoto; K. Kunimi; M. Takikawa; H. Mori; M. Maegawa; M. Kamada; T. Aono; S. Futaki; M. Niwa; S. S. Koide

  Nihon Seishokumeneki Gakkai Zassi, 1997

  
• Steroid 5 alpha-reductase type 1 immunolocalized in the anterior pituitary of intact and castrated male rats

  H Yokoi; Y Tsuruo; T Miyamoto; K Kitagawa; S Futaki; K Ishimura

  HISTOCHEMISTRY AND CELL BIOLOGY, Oct. 1996, Peer-reviewed

  
• Sequence analysis of inducible nitric oxide synthase in rat kidney, lung, and uterus

  Y Tsutsumishita; Y Kawai; H Takahara; T Onda; J Miyoshi; S Futaki; M Niwa

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Oct. 1996, Peer-reviewed

  
• Suppression of inducible nitric oxide synthase mRNA expression by tryptoquinone A

  M Niwa; Y Tsutsumishita; Y Kawai; H Takahara; N Nakamura; S Futaki; Y Takaishi; W Kondoh; H Moritoki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 1996, Peer-reviewed

  
• Immunohistochemical presence of 5 alpha-reductase rat type 1-containing cells in the rat brain

  Y Tsuruo; T Miyamoto; H Yokoi; K Kitagawa; S Futaki; K Ishimura

  BRAIN RESEARCH, May 1996, Peer-reviewed

  
• Impaired fertility in female rats immunized with synthetic peptide segments of two sperm proteins

  H Negishi; YK Jaiswal; S Yamamoto; M Kamada; S Futaki; SS Koide

  BIOCHEMICAL ARCHIVES, May 1996, Peer-reviewed

  
• T-cell membrane-associated serine protease, tryptase TL(2), binds human immunodeficiency virus type 1 gp120 and cleaves the third-variable-domain loop of gp120 - Neutralizing antibodies of human immunodeficiency virus type 1 inhibit cleavage of gp120

  Y Niwa; M Yano; S Futaki; Y Okumura; H Kido

  EUROPEAN JOURNAL OF BIOCHEMISTRY, Apr. 1996, Peer-reviewed

  
• Immunocytochemical localization of 5 alpha-reductase type 1 in the prostate of normal and castrated rats

  T Miyamoto; S Kagawa; K Kitagawa; S Futaki; H Yokoi; Y Tsuruo; K Ishimura

  HISTOCHEMISTRY AND CELL BIOLOGY, Feb. 1996, Peer-reviewed

  
• Pseudo-symmetrical protein: Construction of a four-helix-bundle protein with four intramolecular disulfide cross-linkings

  S Futaki; T Ishikawa; M Niwa; T Yagami; K Kitagawa

  TETRAHEDRON LETTERS, Jan. 1996, Peer-reviewed

  
• Immunocytochemical localization of 5α-reductase type 1 in the prostate of normal and castrated rats

  Tadayuki Miyamoto; Susumu Kagawa; Kouki Kitagawa; Shiroh Futaki; Hiromichi Yokoi; Yoshihiro Tsuruo; Kazunori Ishimura

  Histochemistry and Cell Biology, 1996, Peer-reviewed

  
• Assembling of alpha-helices corresponding to the transmembrane region of sodium channel and the channel activity

  S Futaki; M Aoki; M Niwa; K Kitagawa; H Miyoshi; Y Nakaya

  PEPTIDE CHEMISTRY 1995, 1996, Peer-reviewed

  
• Steroid 5α-reductase type 1 immunolocalized in the anterior pituitary of intact and castrated male rats

  Hiromichi Yokoi; Yoshihiro Tsuruo; Tadayuki Miyamoto; Kouki Kitagawa; Shiroh Futaki; Kazunori Ishimura

  Histochemistry and Cell Biology, 1996

  
• ANALYSIS OF SULFATED TYROSINE-CONTAINING PEPTIDES BY LIQUID SECONDARY-ION MASS-SPECTROMETRY WITH CONSTANT NEUTRAL-LOSS (80 AMU) SCANNING

  T YAGAMI; K KITAGAWA; S FUTAKI

  ANALYTICAL SCIENCES, Dec. 1995, Peer-reviewed

  
• PEPTIDE-UNIT ASSEMBLING USING S-ALKYLATION - A HIGHLY DENATURATION RESISTANT PROTEIN WAS OBTAINED

  S FUTAKI; T ISHIKAWA; M NIWA; K KITAGAWA; T YAGAMI

  TETRAHEDRON LETTERS, Jul. 1995, Peer-reviewed

  
• LIQUID SECONDARY-ION MASS-SPECTROMETRY OF PEPTIDES CONTAINING MULTIPLE TYROSINE-O-SULFATES

  T YAGAMI; K KITAGAWA; S FUTAKI

  RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 1995, Peer-reviewed

  
• CONSTRUCTION AND CHARACTERIZATION OF DENOVO DESIGNED 4-HELIX-BUNDLE PROTEINS AND THEIR POTENTIAL FOR THE ELUCIDATION OF PROTEIN FUNCTION

  S FUTAKI; M AOKI; T ISHIKAWA; H WATANABE; F KONDO; M NIWA; K KITAGAWA; T YAGAMI

  PEPTIDE CHEMISTRY 1994, 1995, Peer-reviewed

  
• PREPARATION OF THE PROTECTED PEPTIDE FRAGMENTS WITH SAFETY-CATCH-TYPE PROTECTING GROUPS AND APPLICATION TO THE SOLID-PHASE FRAGMENT CONDENSATION

  K KITAGAWA; S SHIWA; K SATOH; S FUTAKI

  PEPTIDE CHEMISTRY 1994, 1995, Peer-reviewed

  
• DETECTION OF IMMUNOGLOBULIN BINDING-FACTOR BY ENZYME-LINKED-IMMUNOSORBENT-ASSAY USING 2 MONOCLONAL-ANTIBODIES

  M KAMADA; N MAEDA; M MAEGAWA; H MORI; S YAMAMOTO; T AONO; M MURAGUCHI; Y OHMOTO; S FUTAKI; F OGUSHI; S SONE; H KANAYAMA; S KAGAWA; SS KOIDE

  BIOCHEMISTRY AND MOLECULAR BIOLOGY INTERNATIONAL, Oct. 1994, Peer-reviewed

  
• A NOVEL-APPROACH FOR THE SYNTHESIS OF TYROSINE SULFATE-CONTAINING PEPTIDES USING A SAFETY CATCH TYPE PROTECTING GROUP AS A KEY FEATURE

  K KITAGAWA; S FUTAKI; T YAGAMI

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Aug. 1994, Peer-reviewed

  
• ADAMANTANE AS A BRAIN-DIRECTED DRUG CARRIER FOR POORLY ABSORBED DRUG .2. AZT DERIVATIVES CONJUGATED WITH THE 1-ADAMANTANE MOIETY

  N TSUZUKI; T HAMA; M KAWADA; A HASUI; R KONISHI; S SHIWA; Y OCHI; S FUTAKI; K KITAGAWA

  JOURNAL OF PHARMACEUTICAL SCIENCES, Apr. 1994, Peer-reviewed

  
• IMMUNOGLOBULIN BINDING-FACTOR - A NEW TUMOR-MARKER FOR PROSTATIC TUMORS

  N MAEDA; M KAMADA; T DAITOH; M MAEGAWA; K HIRANO; T AONO; T SHIOTSU; H KANAYAMA; S KAGAWA; S FUTAKI; M MURAGUCHI; Y OHMOTO; ZG LIANG; SS KOIDE

  PROSTATE, Mar. 1994, Peer-reviewed

  
• PEPTIDE-UNIT ASSEMBLING USING DISULFIDE CROSS-LINKING - A NEW APPROACH FOR CONSTRUCTION OF PROTEIN MODELS

  S FUTAKI; K KITAGAWA

  TETRAHEDRON LETTERS, Feb. 1994, Peer-reviewed

  
• SOLID-PHASE SYNTHESIS OF CIONIN, A PROTOCHORDATE-DERIVED OCTAPEPTIDE RELATED TO THE GASTRIN/CHOLECYSTOKININ FAMILY OF PEPTIDES, AND ITS MONO-TYROSINE-SULFATE-CONTAINING DERIVATIVES

  K KITAGAWA; S FUTAKI; T YAGAMI; S SUMI; K INOUE

  INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, Feb. 1994, Peer-reviewed

  
• CONSTRUCTION OF ALPHA-HELIX BUNDLE PROTEINS USING PEPTIDE-UNIT ASSEMBLING

  S FUTAKI; T ISHIKAWA; K KITAGAWA; T YAGAMI

  PEPTIDE CHEMISTRY 1993, 1994, Peer-reviewed

  
• CHEMICAL SYNTHESIS AND MASS-SPECTROMETRIC CHARACTERIZATION OF A MULTIPLY SULFATED PEPTIDE

  K KITAGAWA; T YAGAMI; S SHINOMIYA; S FUTAKI

  PEPTIDE CHEMISTRY 1993, 1994, Peer-reviewed

  
• Solid‐phase synthesis of cionin, a protochordate‐derived octapeptide related to the gastrin/cholecystokinin family of peptides, and its mono‐tyrosine‐sulfate‐containing derivatives

  KOUKI KITAGAWAI; SHIROH FUTAKI; TAKESHI YAGAMI; SHOICHIRO SUMI; KAZUTOMO INOUE

  International Journal of Peptide and Protein Research, 1994

  
• Detection of immunoglobulin binding factor by enzyme-linked immunosorbent assay using two monoclonal antibodies

  M. Kamada; N. Maeda; M. Maegawa; H. Mori; S. Yamamoto; T. Aono; M. Muraguchi; Y. Ohmoto; S. Futaki; F. Ogushi; S. Sone; H. Kanayama; S. Kagawa; S. S. Koide

  Biochemistry and Molecular Biology International, 1994

  
• MOLECULAR-CLONING AND CHARACTERIZATION OF A NOVEL NEUTROPHIL CHEMOTACTIC FACTOR FROM A FILARIAL PARASITE

  M OWHASHI; S FUTAKI; K KITAGAWA; Y HORII; H MARUYAMA; H HAYASHI; Y NAWA

  MOLECULAR IMMUNOLOGY, Oct. 1993, Peer-reviewed

  
• IMMUNOGLOBULIN BINDING-FACTOR IN HUMAN SEMINAL PLASMA - IMMUNOLOGICAL FUNCTION

  N MAEDA; M KAMADA; T DAITOH; T AONO; S FUTAKI; ZG LIANG; SS KOIDE

  ARCHIVES OF ANDROLOGY, Jul. 1993, Peer-reviewed

  
• KINETIC AND STEREOCHEMICAL COMPARISON OF WILD-TYPE AND ACTIVE-SITE K145Q MUTANT ENZYME OF BACTERIAL D-AMINO-ACID TRANSAMINASE

  MB BHATIA; S FUTAKI; H UENO; JM MANNING; D RINGE; T YOSHIMURA; K SODA

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 1993, Peer-reviewed

  
• EVALUATION OF THE FINAL DEPROTECTION SYSTEM FOR THE SOLID-PHASE SYNTHESIS OF TYR(SO3H)-CONTAINING PEPTIDES WITH 9-FLUORENYLMETHYLOXYCARBONYL (FMOC)-STRATEGY AND ITS APPLICATION TO THE SYNTHESIS OF CHOLECYSTOKININ (CCK)-12

  T YAGAMI; S SHIWA; S FUTAKI; K KITAGAWA

  CHEMICAL & PHARMACEUTICAL BULLETIN, Feb. 1993, Peer-reviewed

  
• Immunoglobulin binding factor in human seminal plasma: Immunological function

  N. Maeda; M. Kamada; T. Daitoh; T. Aono; S. Futaki; Z. G. Liang; S. S. Koide

  Archives of Andrology, 01 Jan. 1993

  
• Kinetic and stereochemical comparison of wild-type and active-site K145Q mutant enzyme of bacterial D-amino acid transaminase

  M. B. Bhatia; S. Futaki; H. Ueno; J. M. Manning; D. Ringe; T. Yoshimura; K. Soda

  Journal of Biological Chemistry, 01 Jan. 1993

  
• A NOVEL NEUTROPHIL CHEMOTACTIC PEPTIDE INCLUDED IN THE EPITOPE OF A PARASITE-DERIVED CHEMOTACTIC FACTOR FOR NEUTROPHILS

  M OWHASHI; S FUTAKI; K KITAGAWA; Y HORII; Y NAWA; H HAYASHI

  PEPTIDE CHEMISTRY 1992, 1993, Peer-reviewed

  
• IMMUNOGLOBULIN BINDING-FACTOR IN HUMAN SEMINAL PLASMA - PURIFICATION, CHARACTERIZATION AND IMMUNOLOGICAL FUNCTION

  N MAEDA; S FUTAKI; K KITAGAWA; M KAMADA; T DAITOH; T AONO; ZG LIANG; SS KOIDE

  PEPTIDE CHEMISTRY 1992, 1993, Peer-reviewed

  
• SYNTHETIC STUDY OF TYR (SO3H)-CONTAINING PEPTIDES

  K KITAGAWA; S FUTAKI; T YAGAMI; T TAIKE; S SHIWA

  PEPTIDE CHEMISTRY 1992, 1993, Peer-reviewed

  
• Immunoglobulin binding factor in human seminal plasma: Immunological function

  N. Maeda; M. Kamada; T. Daitoh; T. Aono; S. Futaki; Z. G. Liang; S. S. Koide

  Systems Biology in Reproductive Medicine, 1993

  
• SYNTHESES OF 2 TYROSINE SULFATE CONTAINING PEPTIDES, LEUCOSULFAKININ (LSK)-II AND CHOLECYSTOKININ (CCK)-12, USING THE O-PARA-(METHYLSULPHINYL)BENZYL SERINE FOR THE SELECTIVE SULFATION OF TYROSINE

  S FUTAKI; T TAIKE; T AKITA; K KITAGAWA

  TETRAHEDRON, Oct. 1992, Peer-reviewed

  
• INACTIVATION OF DIMERIC D-AMINO-ACID TRANSAMINASE BY A NORMAL SUBSTRATE THROUGH FORMATION OF AN UNPRODUCTIVE COENZYME ADDUCT IN ONE SUBUNIT

  AM DELPOZO; T YOSHIMURA; MB BHATIA; S FUTAKI; JM MANNING; D RINGE; K SODA

  BIOCHEMISTRY, Jul. 1992, Peer-reviewed

  
• EFFECT OF SUBSTITUTION OF A LYSYL RESIDUE THAT BINDS PYRIDOXAL-PHOSPHATE IN THERMOSTABLE D-AMINO-ACID AMINOTRANSFERASE BY ARGININE AND ALANINE

  K NISHIMURA; K TANIZAWA; T YOSHIMURA; N ESAKI; S FUTAKI; JM MANNING; K SODA

  BIOCHEMISTRY, Apr. 1991, Peer-reviewed

  
• INTRATHECAL INJECTIONS OF GALANIN AND ITS ANTISERUM AFFECT NOCICEPTIVE RESPONSE OF RAT TO MECHANICAL, BUT NOT THERMAL, STIMULI

  Y KURAISHI; M KAWAMURA; T YAMAGUCHI; T HOUTANI; S KAWABATA; S FUTAKI; N FUJII; M SATOH

  PAIN, Mar. 1991, Peer-reviewed

  
• ADAMANTANE AS A BRAIN-DIRECTED DRUG CARRIER FOR POORLY ABSORBED DRUG - ANTINOCICEPTIVE EFFECTS OF [D-ALA2]LEU-ENKEPHALIN DERIVATIVES CONJUGATED WITH THE 1-ADAMANTANE MOIETY

  N TSUZUKI; T HAMA; T HIBI; R KONISHI; S FUTAKI; K KITAGAWA

  BIOCHEMICAL PHARMACOLOGY, Feb. 1991, Peer-reviewed

  
• Sulphur trioxide/thiol: A novel system for the reduction of methionine sulphoxide

  Shiroh Futaki; Takeshi Yagami; Takashi Taike; Tadashi Akita; Kouki Kitagawa

  Journal of the Chemical Society, Perkin Transactions 1, 01 Dec. 1990

  
• Use of dimethylformamide-sulphur trioxide complex as a sulphating agent of tyrosine

  Shiroh Futaki; Takashi Taike; Takeshi Yagami; Toyoko Ogawa; Tadashi Akita; Kouki Kitagawa

  Journal of the Chemical Society, Perkin Transactions 1, 01 Dec. 1990

  
• SUBSTITUTION OF GLUTAMINE FOR LYSINE AT THE PYRIDOXAL-PHOSPHATE BINDING-SITE OF BACTERIAL D-AMINO-ACID TRANSAMINASE - EFFECTS OF EXOGENOUS AMINES ON THE SLOW FORMATION OF INTERMEDIATES

  S FUTAKI; H UENO; AM DELPOZO; MA POSPISCHIL; JM MANNING; D RINGE; B STODDARD; K TANIZAWA; T YOSHIMURA; K SODA

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1990, Peer-reviewed

  
• SUBSTITUTION OF GLUTAMINE FOR LYSINE AT THE PYRIDOXAL-PHOSPHATE BINDING-SITE OF BACTERIAL D-AMINO-ACID TRANSAMINASE - EFFECTS OF EXOGENOUS AMINES ON THE SLOW FORMATION OF INTERMEDIATES

  S FUTAKI; H UENO; AM DELPOZO; MA POSPISCHIL; JM MANNING; D RINGE; B STODDARD; K TANIZAWA; T YOSHIMURA; K SODA

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1990

  
• USE OF DIMETHYLFORMAMIDE SULFUR-TRIOXIDE COMPLEX AS A SULFATING AGENT OF TYROSINE

  S FUTAKI; T TAIKE; T YAGAMI; T OGAWA; T AKITA; K KITAGAWA

  JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, Jun. 1990, Peer-reviewed

  
• SULFUR-TRIOXIDE THIOL - A NOVEL SYSTEM FOR THE REDUCTION OF METHIONINE SULFOXIDE

  S FUTAKI; T YAGAMI; T TAIKE; T AKITA; K KITAGAWA

  JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, Mar. 1990, Peer-reviewed

  
• Studies on anti-allergic agent. I. 1,2,3-trisubstituted-2-propen-1-one derivatives, 3,4-disubstituted-4-oxo-2-butenoic acids and the related compounds

  H. Hirao; T. Fujita; Y. Iwasaki; H. Ide; S. Inoue; K. Kitagawa; S. Futaki; H. Kawanishi; T. Akita

  Yakugaku Zasshi, 1990, Peer-reviewed

  
• Solution Synthesis of Human Peptide YY (hPYY)

  Kouki Kitagawa; Takahiro Tomoyasu; Shiroh Futaki; Tadashi Akita; Shunichi Higashide; Kazutomo Inoue; Takayoshi Tobe

  Chemical and Pharmaceutical Bulletin, 1990, Peer-reviewed

  
• Facile Reduction of Methionine Sulfoxide with Sulfur Trioxide/Iodide Ion System

  Shiroh Futaki; Takeshi Yagami; Takashi Taike; Toyoko Ogawa; Tadashi Akita; Kouki Kitagawa

  Chemical and Pharmaceutical Bulletin, 1990, Peer-reviewed

  
• A new approach for the synthesis of tyrosine sulphate containing peptides: Use of the p-(methylsulphinyl)benzyl group as a key protecting group of serine

  Shiroh Futaki; Takashi Taike; Tadashi Akita; Kouki Kitagawa

  Journal of the Chemical Society, Chemical Communications, 1990, Peer-reviewed

  
• APPLICATION OF DMF-SO3 COMPLEX TO THE REDUCTION OF MET(O) AND TO THE SULFATION OF TYR

  S FUTAKI; T TAIKE; T YAGAMI; T AKITA; K KITAGAWA

  PEPTIDE CHEMISTRY 1989, 1990, Peer-reviewed

  
• A new approach for the synthesis of tyrosine sulphate containing peptides: Use of the p-(methylsulphinyl)benzyl group as a key protecting group of serine

  Shiroh Futaki; Takashi Taike; Tadashi Akita; Kouki Kitagawa

  Journal of the Chemical Society, Chemical Communications, 1990

  
• ORIENTATION OF CHARGERIN-II (A6L) IN THE ATP SYNTHASE OF RAT-LIVER MITOCHONDRIA DETERMINED WITH ANTIBODIES AGAINST PEPTIDES OF THE PROTEIN

  T ODA; S FUTAKI; K KITAGAWA; Y YOSHIHARA; TANI, I; T HIGUTI

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 1989, Peer-reviewed

  
• SOLUTION SYNTHESIS OF HUMAN NEUROPEPTIDE-Y (HNPY)

  S ONO; K KITAGAWA; S FUTAKI; S KIYAMA; Y OOI; T AKITA; S HIGASHIDE; K INOUE; S SUMI; T TOBE

  CHEMICAL & PHARMACEUTICAL BULLETIN, Jul. 1989, Peer-reviewed

  
• APPLICATION OF THE TRIMETHYLSILYL TRIFLUOROMETHANESULFONATE DEPROTECTING PROCEDURE FOR THE SYNTHESIS OF PORCINE PEPTIDE YY (PYY)

  S ONO; S KIYAMA; K KITAGAWA; S FUTAKI; T NAKAMURA; T TAIKE; T AKITA; S SUMI; K INOUE; M FUJIMURA; T TOBE; H YAJIMA

  INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, Jan. 1989, Peer-reviewed

  
• Solution Syntheses of Two Enkephalin-Containing Peptides, Peptide E and Dynorphin(l—24), Using Nin-(2,4,6-Triisopropylphenylsulfonyl)tryptophan

  Kouki Kitagawa; Tatsuhiko Kawamoto; Shiroh Futaki; Shinya Kiyama; Yoshiaki Kiso; Tadashi Akita; Hideki Moritoki

  Chemical and Pharmaceutical Bulletin, 1989, Peer-reviewed

  
• FACILE REDUCTION OF METHIONINE SULFOXIDE WITH SULFUR-TRIOXIDE THIOL SYSTEM

  S FUTAKI; T TAIKE; T YAGAMI; T AKITA; K KITAGAWA

  TETRAHEDRON LETTERS, 1989, Peer-reviewed

  
• STUDIES ON PEPTIDES .160. SYNTHESIS OF A 33-RESIDUE PEPTIDE CORRESPONDING TO THE ENTIRE AMINO-ACID SEQUENCE OF HUMAN CHOLECYSTOKININ (HCCK-33)

  N FUJII; S FUTAKI; S FUNAKOSHI; K AKAJI; H MORIMOTO; R DOI; K INOUE; M KOGIRE; S SUMI; M YUN; T TOBE; M AONO; M MATSUDA; H NARUSAWA; M MORIGA; H YAJIMA

  CHEMICAL & PHARMACEUTICAL BULLETIN, Sep. 1988, Peer-reviewed

  
• ROLE OF SULFATED TYROSINE RESIDUE IN INFLUENCING THE BIOLOGIC ACTIVITY OF HUMAN CHOLECYSTOKININ-33

  R DOI; K INOUE; M KOGIRE; S SUMI; M YUN; S FUTAKI; N FUJII; H YAJIMA; T TOBE

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 1988, Peer-reviewed

  
• EFFECT OF SYNTHETIC HUMAN CHOLECYSTOKININ-33 ON EXOCRINE PANCREAS

  R DOI; K INOUE; M KOGIRE; S SUMI; M YUN; S FUTAKI; N FUJII; H YAJIMA; T TOBE

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 1988, Peer-reviewed

  
• Synthesis and antifungal activity of a series of novel 2-propen-1-one

  Y. Iwasaki; T. Fujita; H. Yabe; H. Hirao; K. Kitagawa; S. Futaki; T. Inoue; T. Matsuzaki; T. Akita

  Yakugaku Zasshi, 1988, Peer-reviewed

  
• Studies on Peptides. CLIX. Preparation of a Protected 33-Residue Peptide for the Synthesis of Human Cholecystokinin (hCCK-33)

  Nobutaka Fujii; Shiroh Futaki; Susumu Funakoshi; Kenichi Akaji; Hiroshi Morimoto; Osamu Ikemura; Haruaki Yajima

  Chemical and Pharmaceutical Bulletin, 1988, Peer-reviewed

  
• Total synthesis of human cholecystokinin-33

  Nobutaka Fujii; Shiroh Futaki; Hiroshi Morimoto; Kazutomo Inoue; Ryuichiro Doi; Takayoshi Tobe; Haruaki Yajima

  Journal of the Chemical Society, Chemical Communications, 1988, Peer-reviewed

  
• Total synthesis of human cholecystokinin-33

  Nobutaka Fujii; Shiroh Futaki; Hiroshi Morimoto; Kazutomo Inoue; Ryuichiro Doi; Takayoshi Tobe; Haruaki Yajima

  Journal of the Chemical Society, Chemical Communications, 1988

  
• SYNTHESIS AND ANTIFUNGAL ACTIVITY OF AZOLE DERIVATIVES OF 2-PROPEN-1-ONE

  Y IWASAKI; T FUJITA; H YABE; K KITAGAWA; S FUTAKI; T MATSUZAKI; T AKITA

  JOURNAL OF PHARMACEUTICAL SCIENCES, Nov. 1987, Peer-reviewed

  
• PROTEOLYSIS OF HUMAN C-REACTIVE PROTEIN PRODUCES PEPTIDES WITH POTENT IMMUNOMODULATING ACTIVITY

  FA ROBEY; K OHURA; S FUTAKI; N FUJII; H YAJIMA; N GOLDMAN; KD JONES; S WAHL

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 1987, Peer-reviewed

  
• PROTEOLYSIS OF HUMAN C-REACTIVE PROTEIN PRODUCES PEPTIDES WITH POTENT IMMUNOMODULATING ACTIVITY

  FA ROBEY; K OHURA; S FUTAKI; N FUJII; H YAJIMA; N GOLDMAN; KD JONES; S WAHL

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 1987

  
• STUDIES ON PEPTIDES .132. EVALUATION OF 2 BETA-CARBOXYL PROTECTING GROUPS OF ASPARTIC-ACID, CYCLOHEPTYL AND CYCLOOCTYL, FOR PEPTIDE-SYNTHESIS

  FUJII, N; NOMIZU, M; FUTAKI, S; OTAKA, A; FUNAKOSHI, S; AKAJI, K; WATANABE, K; YAJIMA, H

  CHEMICAL & PHARMACEUTICAL BULLETIN, 01 Jan. 1986, Peer-reviewed

  
• Studies on Peptides. CXLIII. Evaluation of β-Menthylaspartate for Peptide Synthesis

  Haruaki Yajima; Shiroh Futaki; Akira Otaka; Takeyoshi Yamashita; Susumu Funakoshi; Kiyoshi Bessho; Nobutaka Fujii; Kenichi Akaji

  Chemical and Pharmaceutical Bulletin, 1986, Peer-reviewed

  
• Studies on Peptides. CXXXIII. Synthesis and Biological Activity of Galanin, a Novel Porcine Intestinal Polypeptide

  Haruaki Yajima; Shiroh Futaki; Nobutaka Fujii; Kenichi Akaji; Susumu Funakoshi; Mitsuya Sakurai; Shinichi Katakura; Kazutomo Inoue; Ryo Hosotani; Takayoshi Tobe; Tomio Segawa; Atsuko Inoue; Kazuhiko Tatemoto; Viktor Mutt

  Chemical and Pharmaceutical Bulletin, 1986, Peer-reviewed

  
• STUDIES ON PEPTIDES .129. APPLICATION OF NIN-MESITYLENESULFONYL-TRYPTOPHAN FOR THE SYNTHESES OF NEUROMEDIN-B AND NEUROMEDIN-C

  N FUJII; S FUTAKI; K AKAJI; H YAJIMA; A INOUE; T SEGAWA

  CHEMICAL & PHARMACEUTICAL BULLETIN, 1985, Peer-reviewed

  
• SYNTHESIS OF GALANIN, A NEW GASTROINTESTINAL POLYPEPTIDE

  H YAJIMA; S FUTAKI; N FUJII; K AKAJI; S FUNAKOSHI; M SAKURAI; S KATAKURA; K INOUE; R HOSOTANI; T TOBE; T SEGAWA; A INOUE; K TATEMOTO; MUTT, V

  JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1985, Peer-reviewed

  
• STUDIES ON PEPTIDES .121. N-IN-MESITYLENESULFONYLTRYPTOPHAN, A NEW DERIVATIVE FOR PEPTIDE-SYNTHESIS

  N FUJII; S FUTAKI; K YASUMURA; H YAJIMA

  CHEMICAL & PHARMACEUTICAL BULLETIN, 1984, Peer-reviewed

  
• STUDIES ON PEPTIDES .122. N-SUCCINIMIDYL-PARA-(2-NITROVINYL)-BENZOATE AND ITS META-ISOMER, AS HETEROBIFUNCTIONAL CONJUGATING REAGENTS FOR IMMUNOASSAY

  N FUJII; Y HAYASHI; S FUTAKI; K AKAJI; H YAJIMA; T KITAGAWA

  CHEMICAL & PHARMACEUTICAL BULLETIN, 1984, Peer-reviewed

  
• Cell-penetrating D-isomer Peptides Consisting of Pas and the p53 C-terminus Induce Autophagic Cell Death of Glioma-initiating Cells

  Ueda, Y; Fan-Yan Wei; Hide, T; Michiue, H; Takayama, K; Kaitsuka, T; Nakamura, H; Makino, K; Kuratsu, J; Futaki, S; Tomizawa, K

  Biomaterials, in press,, Peer-reviewed

  

Misc.

• Screening of G-quadruplex (G4) structure-specific peptide probes

  井田南加; 川口祥正; 二木史朗; 今西未来

  日本薬学会年会要旨集(Web), 2024

  
• Evaluation of an inkjet-based technology for cytosolic delivery of therapeutic molecules using cell-penetrating peptides

  大村美香; 二宮蒼平; 川口祥正; 藤原大佑; 藤原大佑; 道上雅孝; 道上雅孝; 中瀬朋夏; 藤井郁雄; 藤井郁雄; 二木史朗; 中瀬生彦; 中瀬生彦

  日本薬学会年会要旨集(Web), 2024

  
• Development of an Efficient Endosomolytic Peptide for Cytosolic Protein Delivery

  川口祥正; 川村優貴; 清川めぐみ; 広瀬久昭; 樋口ゆり子; 二木史朗

  日本薬学会年会要旨集(Web), 2024

  
• Cell-Specific and Efficient Delivery By SARS-CoV-2 Spike Protein-Loaded Extracellular Vesicles

  中川優奈; 川口祥正; 広瀬久昭; 橋口隆生; 二木史朗

  日本薬学会年会要旨集(Web), 2024

  
• Cytosolic Delivery of Antibodies through L17ER4 Conjugation

  寺田旺之; 川口祥正; 二木史朗

  日本薬学会年会要旨集(Web), 2024

  
• ペプチドによる細胞内送達の効率と遺伝子発現の相関解析

  栗山 理志; 広瀬 久昭; 川口 祥正; 二木 史朗

  日本生化学会大会プログラム・講演要旨集, Oct. 2023

  
• ホウ素中性子捕捉療法(BNCT)における膜透過性ペプチドを用いたホウ素薬剤の細胞内局在制御と細胞死誘導促進

  中瀬生彦; 片山未来; 服部能英; 石村美紀; 稲浦峻亮; 藤原大佑; 中瀬朋夏; 藤井郁雄; 二木史朗; 切畑光統

  日本DDS学会学術集会プログラム予稿集, 2019

  
• 膜透過性RLAペプチドを用いたミトコンドリアへの薬物送達とピレンブチレートの効果的な利用

  片山未来; 中瀬朋夏; 松井千紘; 服部能英; 高橋幸一; 切畑光統; 藤井郁雄; 二木史朗; 中瀬生彦; 中瀬生彦

  膜シンポジウム, 2018

  
• SARS-CoV-2S protein搭載による細胞外小胞の膜融合促進

  中川優奈; 川口祥正; 橋口隆生; 二木史朗

  生体膜と薬物の相互作用シンポジウム講演要旨集, 2023

  
• The mechanism of action of intracellular delivery peptide L17E

  栗山理志; 広瀬久昭; 川口祥正; 二木史朗

  日本薬学会年会要旨集(Web), 2023

  
• 生理活性物質の細胞内送達に向けたMelittin誘導体の創製

  川口祥正; 為本尚樹; 麓昌高; 二木史朗

  生体膜と薬物の相互作用シンポジウム講演要旨集, 2022

  
• Ni(II)/ジピコリルアミン修飾によるオクタアルギニンペプチドの細胞膜透過促進

  川口 祥正; 伊勢 祥子; 二木 史朗

  日本薬学会年会要旨集, Mar. 2022

  
• ペプチド・タンパク質医薬のサイトゾル送達量の定量的評価系構築

  岡野 秀亮; 川口 祥正; 河野 健一; 二木 史朗

  日本薬学会年会要旨集, Mar. 2022

  
• 細胞外小胞の受容細胞への内在化量および膜融合量の定量化技術の開発

  平井 勇祐; 広瀬 久昭; 佐々木 道仁; 澤 洋文; 二木 史朗

  日本生化学会大会プログラム・講演要旨集, Nov. 2021

  
• 膜張力の変化を介した細胞形態制御の試み

  益田俊博; 村山知; 馬場健太郎; 稲垣直之; 二木史朗

  日本薬学会年会要旨集(CD-ROM), Mar. 2018

  
• A method for selective isolation of N-terminal peptide from N-blocked protein by the combination of AspN digestion, transamination, and tosylhydrazine glass treatment

  SONOMURA Kazuhiro; KUYAMA Hiroki; MATSUO Ei-ichi; TSUNASAWA Susumu; FUTAKI Shiroh; NISHIMURA Osamu

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011

  
• Enhancement of intracellular delivery using arginine-rich peptides

  二木 史朗

  化学工業, May 2007

  
• Synthesis of the Big-molecular-form CCK-peptide by a Thioester Segment Condensation Approach

  KITAGAWA Kouki; ADACHI Hiroshi; FUJIWARA Hidetoshi; FUTAKI Shiroh; YAGAMI Takeshi

  Peptide Science 1999, 01 Mar. 2000

  
• DNA結合におけるZIF268亜鉛フィンガードメインのアルギニン残基の重要性

  佐々木麻恵子; 辰谷和弥; 根木滋; 今西未来; 二木史朗; 杉浦幸雄

  日本化学会講演予稿集, 2011

  
• Intracellular Delivery Using Membrane-Permeable Peptides

  FUTAKI Shiroh

  高分子学会予稿集, 04 Sep. 2007

  
• Identification of a receptor responsible for cellular uptake of R12 peptide

  TANAKA Gen; FUKUDA Yasunori; NAKASE Ikuhiko; HATANAKA Yasumaru; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011

  
• Modification with Iminodiacetic Acids for Controlling the DNA Binding of GCN4-bZIP Protein by a Metal Ion

  AZUMA Yusuke; IMANISHI Miki; YOSHIMURA Tomoyuki; KAWABATA Takeo; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011

  
• Properties of modularly assembled zinc finger peptides for creation of engineered transcription regulators

  NAKAMURA Atsushi; IMANISHI Miki; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011

  
• Direct penetration of arginine-rich peptides into cells accompanies dynamic alteration of membrane structures

  HIROSE Hisaaki; TAKEUCHI Toshihide; NAKASE Ikuhiko; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011

  
• Elucidating effects of amphipathic peptides on cell-membrane architecture

  PUJALS Silvia; TANIUCHI Kentaroh; MIYAMAE Hiroki; UMEDA Masato; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011

  
• Time-Dependent Analysis of Artificial Transcription Factors Based on Zinc Finger Peptides

  MORISAKI Tatsuya; IMANISHI Miki; FUTAKI Shiroh; SUGIURA Yukio

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2007

  
• Direct and Efficient Cytosolic Delivery Using Oligoarginine Vectors in the Presence of Pyrenebutyrate

  TAKEUCHI Toshihide; KOSUGE Michie; TADOKORO Akiko; SUGIURA Yukio; NISHI Mayumi; KAWATA Mitsuhiro; SAKAI Naomi; MATILE Stefan; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2007

  
• Membrane-Associated Proteoglycans and Cellular Uptake of Arginine-Rich Peptides

  TADOKORO Akiko; NAKASE Ikuhiko; KAWABATA Noriko; TAKEUCHI Toshihide; SUGIURA Yukio; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2007

  
• Transmission of Extramembrane Conformational Switch into Channel Current : Design and Construction of Artificial Metal-Gated Receptor Channel

  KIWADA Tatsuto; SONOMURA Kazuhiro; SUGIURA Yukio; ASAMI Koji; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2007

  
• Highly efficeint intracellular delivery as a biothnology for sustainability science

  二木 史朗; 中瀬 生彦; 森井 孝

  生存基盤科学研究ユニット研究成果報告書, 2006

  
• アルギニンペプチドの細胞膜透過--機序と展開 (第25回生体膜と薬物の相互作用シンポジウム--ダイナミックインターフェイスとしての生体膜 講演要旨集)

  二木 史朗; 中瀬 生彦; 丹羽 美紀

  薬学雑誌, 13 Nov. 2003

  
• Mechanistic Study of Membrane Transport of Octaarginine, Stearylated-octaarginine and Octaarginine-modified Liposomes (第25回生体膜と薬物の相互作用シンポジウム--ダイナミックインターフェイスとしての生体膜 講演要旨集)

  Khalil Ikramy A.; Futaki Shiroh; Harashima Hideyoshi

  薬学雑誌, 13 Nov. 2003

  
• Highly efficient intracellular delivery as a biotechnology for sustainability science

  二木 史朗; 中瀬 生彦; 森井 孝

  生存基盤科学研究ユニット研究成果報告書, 2007

  
• Stability and Self-Association of a Model Transmembrane Helix in Lipid Bilayers

  YANO Yoshiaki; TAKEMOTO Tomokazu; KOBAYASHI Satoe; OHASHI Wakana; NIWA Miki; FUTAKI Shiroh; SUGIURA Yukio; MATSUZAKI Katsumi

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2001

  
• Characteristics of Membrane Permeable Arginine-Rich Peptides

  SUZUKI Tomoki; OHASHI Wakana; NAKASE Ikuhiko; TANAKA Seigo; UEDA Kunihiro; FUTAKI Shiroh; SUGIURA Yukio

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2001

  
• Application of Arginine-Rich RNA-Binding Peptides to Gene Delivery

  OHASHI Wakana; SUZUKI Tomoki; NAKASE Ikuhiko; TANAKA Seigo; UEDA Kunihiro; FUTAKI Shiroh; SUGIURA Yukio

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2001

  
• Intracellular Delivery of Synthetic Peptides Mediated by Tat-related Peptides

  FUTAKI Shiroh; SUZUKI Tomoki; OHASHI Wakana; YAGAMI Takeshi; TANAKA Seigo; UEDA Kunihiro; SUGIURA Yukio

  Peptide Science 1999, 01 Mar. 2000

  
• ポストゲノム時代の創薬を目指して〜タンパク質にできること・タンパク質ならできること〜 エンドソーム不安定化ペプチドを用いた細胞内への機能性タンパク質の導入

  秋柴 美沙穂; 武内 敏秀; 川口 祥正; 坂本 健太郎; 中瀬 生彦; 二木 史朗

  日本薬学会年会要旨集, Mar. 2018

  
• ニーマンピック病C型治療薬としての新規膜透過性シクロデキストリンの可能性評価

  西山 怜奈; 本山 敬一; 前田 有紀; 東 大志; 川口 祥正; 二木 史朗; 石塚 洋一; 近藤 悠希; 入江 徹美; 江良 択実; 有馬 英俊

  日本薬学会年会要旨集, Mar. 2017

  
• エンドソーム膜を不安定化する新規ペプチドの開発と抗体の細胞内送達

  秋柴 美沙穂; 武内 敏秀; 川口 祥正; 坂本 健太郎; 二木 史朗

  日本薬学会年会要旨集, Mar. 2017

  
• オクタアルギニンを介した細胞内タンパク質送達法の細胞質輸送効率を評価するためのMALDI-TOF型質量分析計を用いた分析法(A MALDI-TOF mass spectroscopy-based approach to evaluate the cytosolic translocation efficiency of octaarginine-mediated intracellular protein delivery)

  Arafiles Jan Vincent; 川口 祥正; Cherine Bechara; Erancoise Illien; 河野 健一; Fabienne Burlina; Sandrine Sagan; 二木 史朗

  日本薬学会年会要旨集, Mar. 2017

  
• オクタアルギニンと血清タンパク質の相互作用

  野村 佳世; 河野 健一; 川口 祥正; 桑田 啓子; 二木 史朗

  日本薬学会年会要旨集, Mar. 2017

  
• ジピコリルアミン修飾オクタアルギニンと金属の錯体形成による膜透過促進

  伊勢 祥子; 川口 祥正; 武内 敏秀; 二木 史朗

  日本薬学会年会要旨集, Mar. 2016

  
• グルタミン酸を導入した毒素ペプチド変異体による抗体の細胞内送達

  秋柴 美沙穂; 川口 祥正; 武内 敏秀; 二木 史朗

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• オクタアルギニン-ユビキチンコンジュゲートを利用したR8の細胞内在化量の定量

  川口 祥正; Bechara Cherine; Yu Hao-Hsin; 中瀬 生彦; 今西 未来; 武内 敏秀; Burlina Fabienne; Sagan Sandrine; 二木 史朗

  日本薬学会年会要旨集, Mar. 2015

  
• 天然由来の膜傷害ペプチドを用いた高分子生理活性物質の細胞内送達法の開発

  秋柴 美沙穂; 武内 敏秀; 川口 祥正; 二木 史朗

  日本薬学会年会要旨集, Mar. 2015

  
• Life-oriented Chemistry in Pharmaceutical Sciences-Chemistry Challenge to Mystery of Life

  Shigeki Sasaki; Shiroh Futaki

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Apr. 2014, Peer-reviewed

  
• 光架橋法によるオクタアルギニンペプチドの細胞内移行関連タンパク質の同定

  川口 祥正; 田中 弦; 中瀬 生彦; 武内 敏秀; 畑中 保丸; 二木 史朗

  日本薬学会年会要旨集, Mar. 2014

  
• 3P207 Preferential Perturbation of Positively Curved Membranes by Adenovirus-derived Amphiphilic Peptide(Biological & Artificial membrane: Structure & Property,Poster,The 52th Annual Meeting of the Biophysical Society of Japan(BSJ2014))

  Tomo Murayama; Silvia Pujals; Shiroh Futaki

  Seibutsu Butsuri, 2014

  
• 3P201 The Sequence Effects of the Amphypathic Peptides of Adenovirus Protein VI on Their Curvature Inducing Ability(13A. Biological & Artifical membrane: Structure & Property,Poster)

  Murayama Tomo; Pujals Silvia; Futaki Shiroh

  Seibutsu Butsuri, 2013

  
• 1A1724 Effects of bending modulus on the deformation of lipid membrane by cell-penetrating peptide(Biol & Artifi memb 1: Structure & Property, Dynamics,The 49th Annual Meeting of the Biophysical Society of Japan)

  Kawamoto Shuhei; Takasu Masako; Miyakawa Takeshi; Morikawa Ryota; Oda Tatsuki; Saito Hiroaki; Futaki Shiroh; Nagao Hidemi

  Seibutsu Butsuri, 2011

  
• 2SB-03 Cell-penetrating peptides as a tool for intracellular delivery(2SB Frontiers in chemical biology for in-cell biophysics,The 49th Annual Meeting of the Biophysical Society of Japan)

  Futaki Shiroh

  Seibutsu Butsuri, 2011

  
• 1P240 Vesicle membrane translocation of cell-penetrating peptide studied by coarse-grained simulations(Biol & Artifi memb.:Dynamics,The 48th Annual Meeting of the Biophysical Society of Japan)

  Kawamoto Shuhei; Takasu Masako; Oda Tatsuki; Futaki Shiroh; Nagao Hidemi

  Seibutsu Butsuri, 2010

  
• 3P-184 Membrane deformation by arginine-rich peptide(Biol & Artifi memb.:Dynamics,The 47th Annual Meeting of the Biophysical Society of Japan)

  Kawamoto Shuhei; Takasu Masako; Nagao Hidemi; Futaki Shiroh

  Seibutsu Butsuri, 2009

  
• Arginine-rich ペプチドを用いた細胞内デリバリー

  二木 史朗

  Drug delivery system, 10 Jul. 2001

  
• Chemical Synthesis of Proteins Corresponding to the Zinc Finger Domain of Sp1

  KIWADA Tatsuto; FUTAKI Shiroh; SHIRAISHI Yasuhisa; SUGIURA Yukio

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2004

  
• 塩基性ペプチドを用いたタンパク質・核酸の効率的細胞内導入

  二木 史朗

  Drug delivery system, 10 May 2002

  
• Artificial Zinc Finger Peptide Containing a Novel His4 Domain (BIOORGANIC CHEMISTRY-Bioactive Chemistry)

  Hori Yuichiro; Suzuki Kazuo; Okuno Yasushi; Nagaoka Makoto; Futaki Shiroh; Sugiura Yukio

  ICR annual report, Mar. 2001

  Access this misc :

  
• Modulation of Alamethicin Assembly by Hybridization

  FUTAKI Shiroh; OMOTE Masayuki; SUGIURA Yukio; FUKUDA Masayuki; NIWA Mineo

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Oct. 1998

  
• Preparation of Peptide Thioester Segments Using Fmoc-Solid-Phase Peptide Synthesis

  FUTAKI Shiroh; SOGAWA Koji; FUKUDA Masayuki; HOJO Hironobu; NIWA Mineo

  Peptide chemistry : proceedings of the ... Symposium on Peptide Chemistry, 01 Oct. 1996

  
• An Approach to Explore Proteins Involved in the Internalization of Arginine-Rich Peptides Using Photocrosslinking

  KAWAGUCHI Yoshimasa; TANAKA Gen; FUKUDA Yasunori; NAKASE Ikuhiko; HATANAKA Yasumaru; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2012

  
• A New Method of Protein Cross-Linking for the Preparation of Deubiquitinating Enzyme Resistant Ubiquitin Dimer

  OKU Akihiko; YU Hao-Hsin; NAKASE Ikuhiko; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2012

  
• Counteranion-Mediated Delivery of Arginine-Rich Peptides into Living Cells

  TAKEUCHI Toshihide; KOSUGE Michie; TADOKORO Akiko; SUGIURA Yukio; NISHI Mayumi; KAWATA Mitsuhiro; SAKAI Naomi; MATILE Stefan; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2006

  
• The Effect of Octaarginine on the Translocation of Daunomycin-branched Polypeptide Conjugates

  BANOCZI Zoltan; REMENYI Judit; TAKEUCHI Toshihide; FUTAKI Shiroh; HUDECZ Ferenc

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2006

  
• Construction of ion-channel models using synthetic peptides

  FUTAKI S.

  Biophysics, Oct. 1997

  
• Highly efficient intracellular delivery as a biotechnology for sustainability science

  二木 史朗; 中瀬 生彦; 森井 孝

  生存基盤科学研究ユニット研究成果報告書, 2009

  
• 22pJF-5 Four kinds of deformations of lipid bilayer membrane induced by cell-penetrating peptide

  Kawamoto Shuhei; Takasu Masako; Miyakawa Takeshi; Morikawa Ryota; Oda Tatsuki; Saito Hiroaki; Futaki Shiroh; Nagao Hidemi

  Meeting abstracts of the Physical Society of Japan, 24 Aug. 2011

  
• 28aGV-11 Coulomb interaction for inverted micelle formation by cell-penetrating peptide : A coarse-grained simulation study

  Kawamoto Shuhei; Takasu Masako; Miyakawa Takeshi; Morikawa Ryota; Oda Tatsuki; Saito Hiroaki; Futaki Shiroh; Nagao Hidemi

  Meeting abstracts of the Physical Society of Japan, 03 Mar. 2011

  
• 26aPS-23 Inverted micelles induced by peptides in lipid bilayer membrane : A coarse-grained simulation study

  Kawamoto Shuhei; Takasu Masako; Oda Tatsuki; Futaki Shiroh; Nagao Hidemi

  Meeting abstracts of the Physical Society of Japan, 18 Aug. 2010

  
• 26pPSA-40 Membrane deformation of cell-penetrating peptides

  Kawamoto Shuhei; Takasu Masako; Nagao Hidemi; Futaki Shiroh

  Meeting abstracts of the Physical Society of Japan, 18 Aug. 2009

  
• 23aPS-127 Membrane deformation of cell-penetrating peptides

  Kawamoto Shuhei; Takasu Masako; Nagao Hidemi; Oda Tatsuki; Futaki Shiroh

  Meeting abstracts of the Physical Society of Japan, 01 Mar. 2010

  
• Effect of linker sequence on DNA recognition by multi-zine finger protein / Intracellular protein delivery using arginine-rich basic peptides (BIOORGANIC CHEMISTRY - Bioactive Chemistry)

  SUGIURA Yukio; FUTAKI Shiroh; NAGAOKA Makoto; PEI Renjun

  ICR annual report, Mar. 2002

  
• 2S2-PM3 Intracellular delivery using cell-permeable peptides

  FUTAKI Shiroh

  日本生物工学会大会講演要旨集, 2005

  
• エクソソーム形成分泌及び細胞内移行におけるpH培養環境変化の影響

  植野菜摘; 松沢美恵; 野口公輔; 竹中智哉; 杉山綾香; ベイリー小林菜穂子; ベイリー小林菜穂子; 橋本拓弥; 中瀬朋夏; 弓場英司; 藤井郁雄; 二木史朗; 吉田徹彦; 吉田徹彦; 中瀬生彦

  日本膜学会年会講演要旨集, 10 Apr. 2019

  
• 心筋細胞ミトコンドリアを標的とした膜透過性アルギニンペプチドとピレンブチレートを用いた薬物送達

  片山 未来; 中瀬 朋夏; 松井 千紘; 服部 能英; 高橋 幸一; 切畑 光統; 藤井 郁雄; 二木 史朗; 中瀬 生彦

  日本DDS学会学術集会プログラム予稿集, Jun. 2017

  
• アルギニンペプチドとピレンブチレート利用した心筋細胞ミトコンドリアへの効果的な薬物送達

  片山 未来; 中瀬 朋夏; 松井 千紘; 服部 能英; 高橋 幸一; 切畑 光統; 藤井 郁雄; 二木 史朗; 中瀬 生彦

  日本薬学会年会要旨集, Mar. 2017

  
• DEVELOPMENT OF PEPTIDE TOOLS FOR INTRACELLULAR DELIVERY OF ANTIBODIES

  M. Akishiba; T. Takeuchi; Y. Kawaguchi; K. Sakamoto; I. Nakase; S. Futaki

  JOURNAL OF PEPTIDE SCIENCE, Sep. 2016

  
• MEMBRANE-REMODELING AMPHIPATHIC PEPTIDES ENHANCE DIRECT PENETRATION OF OCTAARGININE

  T. Murayama; S. Futaki

  JOURNAL OF PEPTIDE SCIENCE, Sep. 2016

  
• PHOTOCROSSLINKING APPROACHES TO IDENTIFY CELLULAR-UPTAKE RECEPTORS OF ARGININE-RICH CELL-PENETRATING PEPTIDES

  S. Futaki; Y. Kawaguchi; T. Takeuchi; K. Kuwata

  JOURNAL OF PEPTIDE SCIENCE, Sep. 2016

  
• CELL PENETRATION OF DIPICOLYLAMINE-MODIFIED R8 FACILITATED BY METAL COMPLEX FORMATION

  S. Ise; Y. Kawaguchi; T. Takeuchi; K. Kawano; S. Futaki

  JOURNAL OF PEPTIDE SCIENCE, Sep. 2016

  
• EFFECTIVE INTRACELLULAR DELIVERY BASED ON BIOFUNCTIONAL PEPTIDE-MODIFIED EXOSOMES

  I. Nakase; K. Noguchi; N. Ueno; M. Katayama; N. Bailey Kobayashi; T. Takatani-Nakase; T. Yoshida; I. Fujii; S. Futaki

  JOURNAL OF PEPTIDE SCIENCE, Sep. 2016

  
• ニーマンピック病C型様細胞の細胞内コレステロール量に及ぼすオクタアルギニン修飾シクロデキストリンの影響

  西山 怜奈; 本山 敬一; 東 大志; 石塚 洋一; 近藤 悠希; 入江 徹美; 江良 択実; 川口 祥正; 二木 史朗; 有馬 英俊

  日本DDS学会学術集会プログラム予稿集, Jun. 2016

  
• Modifying exosomes with arginine-rich peptides enhances cellular exosome uptake by inducing macropinocytosis

  Ikuhiko Nakase; Kosuke Noguchi; Nahoko Bailey Kobayashi; Tomoka Takatani-Nakase; Tetsuhiko Yoshida; Ikuo Fujii; Shiroh Futaki

  Peptide Science, 2016, Peer-reviewed

  
• POSITIVE MEMBRANE CURVATURE INDUCED BY EPSIN N-TERMINAL PEPTIDE BOOSTS TRANSLOCATION OF OLIGOARGININE THROUGH BIOLOGICAL MEMBRANES: AN APPROACH TOWARDS CURVATURE ENGINEERING

  S. Futaki; As. Pujals; T. Murayama; S. Afonin; H. Miyamae; Ai. Nakase; K. Sakamoto; A. S. Ulrich

  JOURNAL OF PEPTIDE SCIENCE, Sep. 2014

  
• THE SEQUENCE EFFECTSON THECURVATURE SENSITIVE MEMBRANE PERTURBATION OF ADENOVIRUS N-TERMINALPEPTIDE

  T. Murayama; S. Pujals; S. Futaki

  JOURNAL OF PEPTIDE SCIENCE, Sep. 2014

  
• IGF-1Rの自己リン酸化部位由来ペプチドがMCF-7ヒト乳がん細胞に及ぼす影響

  黒田 義弘; 小越 菜保子; 田崎 絵美; 中瀬 生彦; 二木 史朗; 通山 由美; 廣瀬 宗孝

  日本生化学会大会プログラム・講演要旨集, Sep. 2013

  
• Development of Mitochondria-Targeted Cell-Penetrating Peptides and Delivery of Bioactive Molecules

  NAKASE Ikuhiko; KATAYAMA Sayaka; OKUMURA Shinya; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2013

  
• The Role of Pyrenebutyrate on Direct Penetration of Arginine-rich Peptides Through Biological Membranes

  KATAYAMA Sayaka; NAKASE Ikuhiko; NAKATA Yasushi; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2013

  
• Construction of a Calcium-gated Artificial Channel by Fusing Alamethicin with a Calcium Sensor Protein

  NOSHIRO Daisuke; SONOMURA Kazuhiro; YU Hao-Hsin; IMANISHI Miki; ASAMI Koji; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2013

  
• CXCR4によるマクロピノサイトーシスの誘導とHIV‐1感染

  KAWAGUCHI YOSHIMASA; TANAKA GEN; NAKASE IKUHIKO; OISHI SHIN'YA; FUJII NOBUTAKA; SHIMURA KAZUYA; MATSUOKA MASAO; FUTAKI SHIROH

  日本薬学会年会要旨集(CD-ROM), 2013

  
• Single-stranded DNA detection via chemically modified alamethicin nanopore at single molecule level

  R. Kawano; D. Noshiro; T. Osaki; T. Osaki; K. Kamiya; K. Asami; S. Futaki; S. Takeuchi; S. Takeuchi

  17th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2013, 01 Jan. 2013

  
• Creation of Artificial Epidermal Growth Factor Receptor Activated by Bivalent Leucine-zipper Ligand

  Tanaka, G; Nakase, I; Okumura, S; Osaki, K; Futaki, S

  第2回統合物質国際シンポジウム(2012) ,名古屋（名古屋大学）, 10 Dec. 2012, Peer-reviewed

  
• 人工DNA結合蛋白質による細胞分子時計の操作

  今西未来; 中村篤史; 山本和俊; 土居雅夫; 岡村均; 二木史朗

  「細胞を創る」研究会5.0 ,横浜（東京工業大学）, 21 Nov. 2012, Peer-reviewed

  
• 5'-Tthymine recognition by TAL effectors.

  TSUJI, S; Imanishi, M; Futaki, S

  The 39th Inernational Symposium on Nucleic Acids Chemistry ,Toyoda Auditorium, Nagoya University, 16 Nov. 2012, Peer-reviewed

  
• マクロピノサイトーシス誘導受容体としてのCXCR4

  田中 弦; 中瀬生彦; 大石真也; 藤井信孝; 志村和也; 松岡雅雄; 二木史朗

  第34回生体膜と薬物の相互作用シンポジウム(2012) ,京都（京都大学）, 15 Nov. 2012, Peer-reviewed

  
• ミトコンドリアを標的とする膜透過ペプチドの創製と活性分子の細胞内送達

  中瀬生彦; 片山沙綾香; 奥村真也; 二木史朗

  第49回ペプチド討論会 ,かごしま県民交流センター（鹿児島）, 09 Nov. 2012, Peer-reviewed

  
• コラーゲン様ペプチドのコンフォメーション依存的な細胞内への移行

  山崎ちさと; 中瀬生彦; 遠藤裕之; 岸本沙耶; 増山祥弘; 二木史朗; 小出隆規

  第49回ペプチド討論会 ,かごしま県民交流センター（鹿児島）, 09 Nov. 2012, Peer-reviewed

  
• Custom engineering of natural mesoscale-materials for targeted drug and gene-delivery, part 2: Electron microscopic evaluation of polyarganine-derivatized hemocyanins as improved adjuvants and immunogens.

  Silvia Pujals-Riatos; Azumi Yoshimura; Ikuhiko Nakase; Nobuhiro Morone; Shiroh Futaki; John. E. Heuser

  6th Annual Symposium on Nanobiotechnology, Kyoto Cell-Material Integration, Shiran Kaikan, Kyoto University, Japan., 08 Nov. 2012

  
• ROLES OF SYNDECAN-4 AND PKCα FOR CELLULAR UPTAKE OF ARGININE-RICH PEPTIDES

  大崎勝弘; 中瀬生彦; 二木史朗

  第49回ペプチド討論会 ,鹿児島（かごしま県民交流センター ）, 08 Nov. 2012, Peer-reviewed

  
• アルギニンペプチドの直接細胞膜透過を誘起するピレンブチレートの挙動と役割

  片山沙綾香; 中瀬生彦; 中田靖; 二木史朗

  第49回ペプチド討論会 ,鹿児島（かごしま県民交流センター ）, 07 Nov. 2012, Peer-reviewed

  
• アルギニンペプチドの細胞内移行におけるsyndecan-4及びPKCαの寄与

  大崎勝弘; 中瀬生彦; 二木史朗

  第62回日本薬学会近畿支部・大会 ,西宮（武庫川女子大学薬学部浜甲子園キャンパス）, 20 Oct. 2012, Peer-reviewed

  
• モジュール法を用いたガン細胞特異的遺伝子治療薬を指向した高い細胞膜透過性と細胞内環境応答性を有する新規ペプチドリボ核酸の設計・合成と遺伝情報発現制御

  上松亮平; 水谷達哉; 小野寺佳子; 坂本清志; 荒木保幸; 松山洋平; 山吉麻子; 村上章; 中瀬生彦; 二木史朗; 和田健彦

  アンチセンスシンポジウム講演要旨集, 24 Sep. 2012

  
• Period1プロモーターを標的とした人工転写因子による細胞時計のリセット

  今西未来; 中村篤史; 土居雅夫; 二木史朗; 岡村均

  第19回日本時間生物学会学術大会 ,札幌（北海道大学）, 15 Sep. 2012, Peer-reviewed

  
• ミトコンドリアを標的とする細胞膜透過ペプチドベクターの創製

  中瀬生彦; 片山沙綾香; 奥村真也; 二木史朗

  第6回バイオ関連化学シンポジウム ,札幌（北海道大学）, 06 Sep. 2012, Peer-reviewed

  
• Resetting the Cellular Circadian Clock by an Artificial Zinc-finger Transcription Factor

  Imanishi, M; Nakamura, A; Doi, M; Futaki, S; Okamura, H

  FASEB SCIENCE RESEARCH CONFERENCES Genome Engineering: Research & Applications" ,Lucca, Italy, 05 Sep. 2012, Peer-reviewed

  
• In vivoにおけるアルギニンペプチドの腫瘍集積と抗癌剤送達への応用

  中瀬生彦; 小西雄介; 上田真史; 佐治英郎; 二木史朗

  第28回日本DDS学会学術集会 ,札幌（札幌コンベンションセンター）, 05 Jul. 2012, Peer-reviewed

  
• ヘリックス相互作用で活性化可能な人工EGF受容体の創製と細胞機能制御

  中瀬生彦; 大崎勝弘; 奥村真也; 二木史朗

  日本ケミカルバイオロジー学会 第7回年会 ,京都（京都大学百周年時計台記念館）, 09 Jun. 2012, Peer-reviewed

  
• リポソーム内物質のリーケージを金属により制御可能なチャネルペプチドの創製

  能代大輔; 浅見耕司; 二木史朗

  日本ケミカルバイオロジー学会 第7回年会 ,京都（京都大学百周年時計台記念館）, 08 Jun. 2012, Peer-reviewed

  
• 光反応基を用いた細胞膜透過性ペプチドの細胞内移行に関与する候補タンパク質の同定の試み

  川口祥正; 田中弦; 福田保則; 中瀬生彦; 畑中保丸; 二木史朗

  日本ケミカルバイオロジー学会 第7回年会 ,京都（京都大学百周年時計台記念館）, 08 Jun. 2012, Peer-reviewed

  
• Adenovirus internal protein VI由来の両親媒性ペプチドによる膜の形態変化と傷害性に関する研究

  村山知; Pujals S?lvia; 二木史朗

  日本ケミカルバイオロジー学会 第7回年会 ,京都（京都大学百周年時計台記念館）, 07 Jun. 2012, Peer-reviewed

  
• ジンクフィンガーの配位子置換による亜鉛濃度応答性人工転写因子の創製

  今西未来; 辻将吾; 松村一史; 中屋智博; 杉浦幸雄; 二木史朗

  日本ケミカルバイオロジー学会 第7回年会 ,京都（京都大学百周年時計台記念館）, 07 Jun. 2012, Peer-reviewed

  
• 細胞内安定型ユビキチンポリマーの創製と細胞内導入

  奥彰彦; 游晧欣; 吉村智之; 中瀬生彦; 川端猛夫; 二木史朗

  日本ケミカルバイオロジー学会 第7回年会 ,京都（京都大学百周年時計台記念館）, 07 Jun. 2012, Peer-reviewed

  
• 細胞外ドメインの置換によるEGF受容体の会合・活性化制御

  田中弦; 中瀬生彦; 奥村真也; 今西未来; 二木史朗

  第3回統合物質シンポジウム ,福岡（九州大学西新プラザ）, 01 Jun. 2012, Peer-reviewed

  
• Resetting of the cellular circadian clock by an artificial zinc-finger transcription factor

  Imanishi, M; Nakamura, A; Doi, M; Okamura, H; Futaki, S

  金属の関与する生体関連反応シンポジウム(SRM2012) ,金沢（金沢大学）, 31 May 2012, Peer-reviewed

  
• 最新ペプチド合成技術とその創薬研究への応用 第5章 細胞内輸送ペプチドの合成と創薬 2.膜透過性アルギニンペプチドの設計と合成

  中瀬生彦; 田中弦; 二木史朗

  遺伝子医学MOOK, 31 Mar. 2012

  
• 細胞内安定型ユビキチン多量体の構築のための新しいアプローチ

  奥彰彦; 游晧欣; 中瀬生彦; 二木史朗

  日本薬学会第132回年会 ,札幌（北海道大学）, 31 Mar. 2012, Peer-reviewed

  
• 膜障害性に寄与するAdenovirus internal proteinVI の配列デザインに関する研究

  村山知; PUJALS; S?lvia; 二木史朗

  日本薬学会第132回年会 ,札幌（北海道大学）, 30 Mar. 2012, Peer-reviewed

  
• フォトクロスリンカーを用いたアルギニンペプチドの取り込みに関与する細胞分子の探索

  川口祥正; 田中弦; 福田保則; 中瀬生彦; 畑中保丸; 二木史朗

  日本薬学会第132回年会 ,札幌（北海道大学）, 30 Mar. 2012, Peer-reviewed

  
• ミトコンドリアを標的にする膜透過性ペプチドの創製と活性分子送達

  片山沙綾香; 中瀬生彦; 奥村真也; 二木史朗

  日本薬学会第132回年会 ,札幌（北海道大学）, 29 Mar. 2012, Peer-reviewed

  
• ジピコリルアミン含有ヘリックスペプチドのNi(II)イオン特異的応答性

  東佑翼; 今井晴賀; 今西未来; 吉村智之; 川端猛夫; 二木史朗

  日本薬学会第132回年会 ,札幌（北海道大学）, 29 Mar. 2012, Peer-reviewed

  
• In vivoにおける膜透過性ペプチドの腫瘍集積と抗癌剤送達

  中瀬生彦; 小西雄介; 上田真史; 佐治英郎; 二木史朗

  日本薬学会第132回年会 ,札幌（北海道大学）, 29 Mar. 2012, Peer-reviewed

  
• Design and Creation of a Ca2+-sensitive Artificial Channel Protein

  NOSHIRO, Daisuke; SONOMURA, Kazuhiro; Yu H.H; IMANISHI, Miki; ASAMI, Kouji; FUTAKI, Shiroh

  International Symposium on Innovative Nanobiodevices ISIN 2012 ,Nagoya, Japan, 21 Mar. 2012, Peer-reviewed

  
• Metal-Mediated Leakage Control by Histidine-Containing Alamethicin Analogs

  NOSHIRO Daisuke; ASAMI Koji; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2012

  
• A photocross-link approach to identify receptors that stimulate internalization of oligoarginine peptides

  FUTAKI, Shiroh; TANAKA, Gen; NAKASE, Ikuhiko; FUKUDA, Yasunori; MASUDA, Ryo; OISHI, Shinya; FUJII, Nobutaka; HATANAKA, Yasumaru

  8th AFMC International Medicinal Chemistry Symposium “Frontier of Medicinal Science” ,Keio Plaza Hotel Tokyo, 01 Dec. 2011, Peer-reviewed

  
• ヘリックス間相互作用で活性化される人工EGF受容体の創製と細胞機能制御

  中瀬生彦; 大崎勝弘; 奥村真也; 二木史朗

  第2回京都大学GCOE-理化学研究所 共同シンポジウム ,京都（京大桂キャンパス）, 11 Nov. 2011, Peer-reviewed

  
• Circadian Rhythmic Gene Expression Induced by Artificial Clock Proteins

  YAMAMOTO; Kazatoshi; IMANISHI, Miki; HIROSE, Yuka; OKAMURA, Hitoshi; FUTAKI、Shiroh

  The 38th International Symposium on Nucleic Acid Chemistry ,Clark Memorial Student Center, Hokkaido University, 10 Nov. 2011, Peer-reviewed

  
• CXCR4はアルギニンペプチド取り込み促進受容体である：光アフィニティーラベル法によるアプローチ

  田中弦; 川口祥正; 中瀬生彦; 福田保則; 畑中保丸; 二木史朗

  第61回日本薬学会近畿支部大会 ,神戸（神戸学院大学）, 22 Oct. 2011, Peer-reviewed

  
• フォトクロスリンク法によるアルギニンペプチド受容体同定の試み

  二木史朗; 田中弦; 中瀬生彦; 福田保則; 畑中保丸

  反応と合成の進歩シンポジウム講演要旨集, 14 Oct. 2011, Peer-reviewed

  
• 細胞内安定型ユビキチンダイマー構築のための新しいタンパク質架橋法の開発

  奥彰彦; 游晧欣; 中瀬生彦; 二木史朗

  第48回ペプチド討論会 ,札幌（札幌コンベンションセンター）, 28 Sep. 2011, Peer-reviewed

  
• ヒスチジン含有アラメチシン誘導体を用いた金属イオンによるリーケージ制御

  能代大輔; 浅見耕司; 二木史朗

  第48回ペプチド討論会 ,札幌（札幌コンベンションセンター）, 27 Sep. 2011, Peer-reviewed

  
• フォトクロスリンクを用いたアルギニンリッチペプチドの細胞内移行に関与するタンパク質の探索

  川口祥正; 田中弦; 福田保則; 中瀬生彦; 畑中保丸; 二木史朗

  第48回ペプチド討論会 ,札幌（札幌コンベンションセンター）, 27 Sep. 2011, Peer-reviewed

  
• ELUCIDATING THE EFFECT OF EPSIN DERIVED AMPHIPATHIC PEPTIDE ON CELL-MEMBRANE ARCHITECTURE

  PUJALS Silvia; TANIUCHI Kentaroh; MIYAMAE Hiroki; UMEDA Masato; FUTAKI Shiroh

  ペプチド討論会講演要旨集, 27 Sep. 2011, Peer-reviewed

  
• CREATION OF ARTIFICIAL EPIDERMAL GROWTH FACTOR RECEPTOR ACTIVATED BY COILED-COIL PEPTIDES

  NAKASE Ikuhiko; OSAKI Katsuhiro; OKUMURA Shinya; FUTAKI Shiroh

  ペプチド討論会講演要旨集, 27 Sep. 2011, Peer-reviewed

  
• TOPICAL MIGRATION OF MEMBRANE-ASSOCIATED MOLECULES INDUCED BY DIRECT INFLUX OF ARGININE-RICH PEPTIDES INTO CELLS

  HIROSE Hisaaki; TAKEUCHI Toshihide; NAKASE Ikuhiko; FUTAKI Shiroh

  ペプチド討論会講演要旨集, 27 Sep. 2011, Peer-reviewed

  
• IN VIVO TUMOR ACCUMULATION OF ARGININE-RICH CELL-PENETRATING PEPTIDES AND ANTICANCER DRUG DELIVERY

  NAKASE Ikuhiko; KONISHI Yusuke; UEDA Masashi; SAJI Hideo; FUTAKI Shiroh

  ペプチド討論会講演要旨集, 27 Sep. 2011, Peer-reviewed

  
• 新規アラメチシン誘導体による金属を用いたリーケージ制御

  能代大輔; 浅見耕司; 二木史朗

  第５回バイオ関連化学シンポジウム ,つくば（つくば国際会議場「エポカルつくば」）, 13 Sep. 2011, Peer-reviewed

  
• 人工時計タンパク質を用いた周期的遺伝子発現システムの構築

  山本和俊; 今西未来; 二木史朗

  第５回バイオ関連化学シンポジウム ,つくば（つくば国際会議場「エポカルつくば」）, 13 Sep. 2011, Peer-reviewed

  
• 膜透過性R12ペプチドの効率的細胞内移行におけるCXCR4の重要性

  田中弦; 中瀬生彦; 福田保則; 畑中保丸; 二木史朗

  第５回バイオ関連化学シンポジウム ,つくば（つくば国際会議場「エポカルつくば」）, 12 Sep. 2011, Peer-reviewed

  
• 人工時計タンパク質によるリズミックな遺伝子発現の誘起

  今西未来; 山本和俊; 二木史朗

  日本化学会バイオテクノロジー部会シンポジウム講演要旨集, 12 Sep. 2011, Peer-reviewed

  
• EGFRの自己リン酸化部位由来ペプチドのA549ヒト肺腺がん細胞における効果

  黒田 義弘; 村田 恵理; 上田 康陽; 田崎 絵美; 小越 菜保子; 安部 峰大; 宮本 和英; 中瀬 生彦; 二木 史朗; 通山 由美; 廣瀬 宗孝

  日本生化学会大会プログラム・講演要旨集, Sep. 2011

  
• 膜透過ペプチドを用いた細胞内への分子送達

  片山沙綾香; 広瀬久昭; 高山健太郎; 中瀬生彦; 二木史朗

  遺伝子・デリバリー研究会 第11回夏期セミナー ,高知（三翠園ホテル）, 08 Aug. 2011, Peer-reviewed

  
• 膜透過性R12ペプチドの効率的細胞内移行におけるCXCR4の寄与

  田中弦; 中瀬生彦; 福田保則; 二木史朗

  生体機能関連化学部会若手の会 第23回サマースクール ,広島（宮島グランドホテル）, 22 Jul. 2011, Peer-reviewed

  
• ジピコリルアミン骨格をもつペプチドによるニッケル(II)の選択的検出

  東佑翼; 今井晴賀; 今西未来; 吉村智之; 川端猛夫; 二木史朗

  第21回金属の関与する生体関連反応シンポジウム ,千葉（千葉大学）, 30 May 2011, Peer-reviewed

  
• 細胞内移行を促進する膜透過性アルギニンペプチド受容体の同定

  田中弦; 中瀬生彦; 福田保則; 二木史朗

  統合物質創製化学推進事業第２回若手研究会 ,千歳, 28 May 2011, Peer-reviewed

  
• 金属イオンによって安定化されるジピコリルアミン骨格含有単鎖へリックス性ペプチドの設計と合成

  東佑翼; 今井晴賀; 今西未来; 吉村智之; 川端猛夫; 二木史朗

  日本ケミカルバイオロジー学会第6回年会 ,東京（東京工業大学）, 25 May 2011, Peer-reviewed

  
• 膜透過性アルギニンペプチドの効率的細胞内移行におけるCXCR4の寄与

  田中弦; 中瀬生彦; 福田保則; 畑中保丸; 二木史朗

  日本ケミカルバイオロジー学会第6回年会 ,東京（東京工業大学）, 25 May 2011, Peer-reviewed

  
• Alamethicinをベースにした金属イオン感受性人工イオンチャネルの創製

  能代大輔; 浅見耕司; 二木史朗

  日本ケミカルバイオロジー学会第6回年会 ,東京（東京工業大学）, 24 May 2011, Peer-reviewed

  
• DNA Binding Properties of Ligand-Substituted Zinc Finger Proteins

  IMANISHI Miki; NAKAYA Tomohiro; MATSUMURA Kazushi; FUTAKI Shiroh; SUGIURA Yukio

  金属の関与する生体関連反応シンポジウム講演要旨集, 11 May 2011, Peer-reviewed

  
• 細胞透過性オリゴペプチドによるA549ヒト肺線がん細胞に対する細胞増殖抑制、細胞毒性、及びアポトーシスへの影響

  黒田 義弘; 村田 恵理; 上田 康陽; 田崎 絵美; 小越 菜保子; 阿部 峰大; 宮本 和英; 中瀬 生彦; 二木 史朗; 通山 由美; 廣瀬 宗孝

  日本薬学会年会要旨集, Mar. 2011

  
• Design and Creation of Metal-Responsive DNA-Binding Proteins

  FUTAKI Shiroh; IMANISHI Miki; NAKAYA Tomohiro; MORISAKI Tatsuya; NOSHIRO Daisuke; SUGIURA Yukio

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011

  
• Metal-stimulated transcriptional control system using CDH_2-type zinc finger peptides

  NAKAYA Tomohiro; IMANISHI Miki; MORISAKI Tatsuya; NOSHIRO Daisuke; SUGIURA Yukio; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2011

  
• CXCR4 receptor stimulates cellular uptake of polyarginine peptides

  S. Futaki; G. Tanaka; I. Nakase; Y. Fukuda; R. Masuda; S. Oishi; N. Fujii

  BIOPOLYMERS, 2011

  
• Creation of Metal Sensitive Artificial Ion Channels

  D. Noshiro; K. Asami; S. Futaki

  BIOPOLYMERS, 2011, Peer-reviewed

  
• Bidirectional control of the helical structure of a Dpacontaining peptide using divalent metal ions

  Yusuke Azuma; Haruka Imai; Miki Imanishi; Tomoyuki Yoshimura; Takeo Kawabata; Shiroh Futaki

  BIOPOLYMERS, 2011, Peer-reviewed

  
• 膜透過促進配列の付加に伴うアルギニンペプチドの細胞内移行の亢進

  高山健太郎; 中瀬生彦; 二木史朗

  第 9 回次世代を担う若手ファーマ・バイオフォーラム2010 ,京都, 02 Oct. 2010, Peer-reviewed

  
• マクロピノサイトーシスを誘導するR12ペプチド受容体の同定

  田中 弦; 中瀬生彦; 福田保則; 畑中保丸; 二木史朗

  第4回バイオ関連化学シンポジウム ,豊中（大阪大学豊中キャンパス）, 24 Sep. 2010, Peer-reviewed

  
• Dynamics of membrane-associated molecules that accompany direct penetration of arginine-rich peptides into cells

  Hisaaki HIROSE; Toshihide TAKEUCHI; Ikuhiko NAKASE; Shiroh FUTAKI

  The 27th Naito Conference (Membrane Dynamics and Lipid Biology [I]) ,Ch?terais? Gateaux Kingdom SAPPORO, 30 Jun. 2010, Peer-reviewed

  
• Creation of a zinc finger type transcription factor responsive to Zn(II) concentration

  中屋智博; 今西未来; 森崎 達也; 能代 大輔; 二木史朗; 杉浦 幸雄

  金属の関与する生体関連反応シンポジウム ,徳島, 25 Jun. 2010, Peer-reviewed

  
• Design and Creation of the GCN4-bZIP Proteins Functionalized with Iminodiacetic Acid for On/Off Switch of the DNA Binding by Metal Ions

  Azuma Y; Imanishi M; Yoshimura T; Kawabata T; Futaki S

  Gordon Research Conference on Bioorganic Chemistry ,Proctor Academy (Andover, NH), 13 Jun. 2010, Peer-reviewed

  
• Functionalization of GCN4-bZIP with iminodiacetic acid that allow the DNA binding to be controlled by a metal ion

  Azuma Y; Imanishi M; Yoshimura T; Kawabata T; Futaki S

  京大／阪大／ソウル大合同シンポジウム ,吹田（大阪大学）, 20 May 2010, Peer-reviewed

  
• アルギニンペプチドによるマクロピノサイトーシス誘導受容体の同定

  田中 弦; 中瀬生彦; 福田保則; 畑中保丸; 二木史朗

  日本ケミカルバイオロジー学会 第５回年会 ,横浜（慶応義塾大学日吉キャンパス）, 19 May 2010, Peer-reviewed

  
• ゲノムレベルでの時計遺伝子プロモーター解析を目指した亜鉛フィンガー型人工転写因子の創製とその機能

  中村篤史; 中村篤史; 今西未来; 土居雅夫; 岡村均; 二木史朗

  日本ケミカルバイオロジー学会第5年会 ,横浜（慶応義塾大学日吉キャンパス）, 19 May 2010, Peer-reviewed

  
• 亜鉛濃度に依存した新規転写調節系の開発

  中屋智博; 森崎 達也; 能代 大輔; 今西未来; 二木史朗; 杉浦 幸雄

  日本ケミカルバイオロジー学会 第５回 年会 ,横浜, 18 May 2010, Peer-reviewed

  
• ガン細胞特異的遺伝子治療薬を指向した高い細胞膜透過性を有するアルギニン導入α‐ペプチドリボ核酸の設計とmRNAとの相互作用

  和田健彦; 小野寺佳子; 西尾明洋; 澤展也; 坂本清志; 荒木保幸; 中瀬生彦; 二木史朗; 井上佳久

  遺伝子・デリバリー研究会シンポジウム要旨集, 2010

  
• 膜透過促進配列 (Pas) の付加によるアルギニンペプチドの効率的な細胞内移行

  高山健太郎; 中瀬生彦; 二木史朗

  第31回生体膜と薬物の相互作用シンポジウム ,大阪, 01 Dec. 2009, Peer-reviewed

  
• Studies on the effects of arginine residues introduced to peptide ribonucleic acids (PRNA) on the complex stability with RNA.

  A. Nishio; N. Sawa; K. Onodera; S. Sakamoto; Y. Araki; I. Nakase; S. Futaki; Y. Inoue; T. Wada

  Nucleic acids symposium series (2004), 01 Dec. 2009

  
• 膜透過ペプチドを用いた癌増殖抑制ペプチドの細胞内導入

  二木史朗; 高山健太郎; 中瀬生彦

  第28回メディシナルケミストリーシンポジウム ,東京, 25 Nov. 2009, Peer-reviewed

  
• D,L-型ペプチドの構造特性を利用した Peptide[2]catenane および D,L-型ペプチド触媒の創製

  宇留野義治; 東野育代; Orhan O; 椿一典; 二木史朗; 川端猛夫

  第29回有機合成若手セミナー 明日の有機合成を担う人のために ,兵庫, 24 Nov. 2009, Peer-reviewed

  
• ロイシンジッパー型タンパク質への金属配位子の位置選択的導入とDNA結合スイッチ

  二木史朗; 東佑翼; 今西未来; 吉村智之; 川端猛夫

  第35回反応と合成の進歩シンポジウム ,金沢, 16 Nov. 2009, Peer-reviewed

  
• Promoted cellular uptake of arginine-rich peptides bearing penetration accelerating sequences (Pas)

  Takayama K; Nakase Ikuhiko; Michiue Hiroyuki; Takeuchi Toshihide; Tomizawa Kazuhito; Matsui Hideki; Futaki Shiroh

  3rd Asia-Pacific International Peptide Symposium ,Jeju, Korea, 08 Nov. 2009, Peer-reviewed

  
• Expressed Protein Ligation法を用いた膜透過性アルギニンペプチド結合タンパク質の調製と細胞内導入

  游 晧欣; 中瀬 生彦; Silvia Pujals; 今西未来; 二木史朗

  第46回ペプチド討論会 ,北九州, 05 Nov. 2009, Peer-reviewed

  
• アラメチシンのアミノ酸置換とチャネル活性

  二木史朗; 野口晴加; 能代大輔; 浅見耕司

  第46回ペプチド討論会 ,北九州, 05 Nov. 2009, Peer-reviewed

  
• Co(II)-responsive DNA binding switch of the designed GCN4-bZIP protein bearing cysteine moieties functionalized with iminodiacetic acids (Ida)

  Azuma Y; Imanisi M; Yoshimura T; Kawabata T; Futaki, S

  2nd Switzerland-Japan Biomolecular Chemistry Symposium (SJBCS09) ,Tokyo, 01 Nov. 2009, Peer-reviewed

  
• 時計遺伝子プロモーター解析へ向けた亜鉛フィンガー型人工転写因子の創製

  中村篤史; 中村篤史; 今西未来; 土居雅夫; 岡村均; 二木史朗

  第6回アジア睡眠学会 日本睡眠学会第34回定期学術集会 第16回日本時間生物学会学術大会. 2009 合同大会 ,大阪, 27 Oct. 2009, Peer-reviewed

  
• 細胞膜を透過するアルギニンペプチドの細胞内拡散経路に関する検討

  広瀬久昭; 田中 弦; 中瀬生彦; 二木史朗

  第82回日本生化学会 ,神戸, 23 Oct. 2009, Peer-reviewed

  
• In‐cell NMRによるヒト細胞内におけるタンパク質の構造・相互作用・フォールディング安定性の解析

  猪股晃介; 真板(大野)綾子; 杤尾豪人; 磯貝信; 天野剛志; 中瀬生彦; 武内敏秀; 二木史朗; 伊藤隆; 廣明秀一; 白川昌宏

  生化学, 25 Sep. 2009

  
• Cell penetrating peptideを用いたリソソーム性保護タンパク質/カテプシンAの細胞内補充効果の解析

  堀川靖; 辻大輔; 佐野詩織; 中瀬生彦; 二木史朗; 伊藤孝司

  生化学, 25 Sep. 2009

  
• 金属錯形成部位のペプチドへの効率的導入法の開発

  東 佑翼; 今西未来; 吉村 智之; 川端 猛夫; 二木史朗

  第24回生体機能関連化学シンポジウム，第12回バイオテクノロジー部会シンポジウム ,福岡, 14 Sep. 2009, Peer-reviewed

  
• アルギニンおよびセリン含有α‐ペプチドリボ核酸の合成とDNA・RNAとの相互作用

  小野寺佳子; 西尾明洋; 澤展也; 坂本清志; 荒木保幸; 中瀬生彦; 二木史朗; 井上佳久; 和田健彦

  日本化学会バイオテクノロジー部会シンポジウム講演要旨集, 13 Sep. 2009

  
• がん細胞特異的アンチセンス分子のラショナルデザインを目指した人工核酸モジュール法の開発 2

  和田健彦; 澤展也; 西尾明洋; 永見祥; 小野寺佳子; 遠藤絵里子; 水谷達哉; 坂本清志; 荒木保幸; 中瀬生彦; 二木史朗; 井上佳久

  日本化学会バイオテクノロジー部会シンポジウム講演要旨集, 13 Sep. 2009

  
• Stabilization of the Channel Peptide Assembly: Metal Coordination with an Additional Histidine Yielded Extremely Stable Channels

  Noshiro D; Asami K; Futaki S

  2nd Switzerland-Japan Biomolecular Chemistry Symposium (SJBCS09) ,東京, 12 Sep. 2009, Peer-reviewed

  
• 細胞内に移行するコラーゲン様ペプチドのデザイン

  小出隆規; 遠藤裕之; 中瀬生彦; 二木史朗

  第3回関東支部大会 ,東京, 05 Sep. 2009, Peer-reviewed

  
• Cell penetrating peptideを用いたリソソーム性保護タンパク質/カテプシンAの細胞内補充効果の解析

  堀川靖; 辻大輔; 二木史朗; 伊藤孝司

  日本糖質学会年会要旨集, 10 Aug. 2009

  
• Design and creation of a metal-responsive GCN4-bZIP protein modified with iminodiacetic acid (Ida)

  Azuma Y; Imanishi M; Yoshimura T; Kawabata T; Futaki S

  2nd International Symposium on Bioinorganic Chemimstry of the New Era ,Takayama, 02 Aug. 2009, Peer-reviewed

  
• Metal-induced DNA-binding switch of bZIP proteins modified with iminodiacetic acid (Ida)

  Azuma Y; Imanishi M; Yoshimura T; Kawabata T; Futaki S

  The Fifth iCeMS International Symposium, Biomaterials at the interface of chemistry, physics, and biology ,Kyoto, 27 Jul. 2009, Peer-reviewed

  
• 核酸認識特性および細胞膜透過性の向上を目指したペプチドリボ核酸へのアルギニン導入効果

  和田健彦; 西尾明洋; 小野寺佳子; 澤展也; 坂本清志; 荒木保幸; 中瀬生彦; 二木史朗; 井上佳久

  バイオ・高分子シンポジウム講演要旨集, 22 Jul. 2009

  
• Creation of artificial zinc finger-type transcription factors and effects on the rhythmic expression of clock genes

  今西未来; 今西未来; 中村篤史; 二木史朗

  第19回金属の関与する生体関連シンポジウム（SRM 2009） ,吹田（大阪大学）, 12 Jun. 2009, Peer-reviewed

  
• 細胞内におけるマルチ亜鉛フィンガータンパク質のDNA結合特性

  森崎達也; 森崎達也; 今西未来; 二木史朗; 杉浦幸雄

  第9回日本蛋白質科学会年会 ,熊本（熊本全日空ホテルニュースカイ）, 22 May 2009, Peer-reviewed

  
• シスエレメントを標的とした人工ジンクフィンガー連結体のDNA結合性の解析

  今西未来; 今西未来; 中村篤史; 二木史朗

  第9回日本蛋白質科学会年会 ,熊本（熊本全日空ホテルニュースカイ）, 22 May 2009, Peer-reviewed

  
• Metal-induced DNA-binding switch of bZIP proteins modified with iminodiacetic acid (Ida)

  AZUMA Yusuke; IMANISHI Miki; YOSHIMURA Tomoyuki; KAWABATA Takeo; FUTAKI Shiroh

  金属の関与する生体関連反応シンポジウム講演要旨集, 20 May 2009, Peer-reviewed

  
• フェニルボロン酸誘導体を塩基部配向規制内部因子とする細胞内環境応答性ペプチドリボ核酸の合成と可逆的RNA錯体形成制御

  和田健彦; 下司慶一郎; 澤展也; 遠藤絵梨子; 坂本清志; 荒木保幸; 中瀬生彦; 二木史朗; 井上佳久

  高分子学会予稿集(CD-ROM), 12 May 2009

  
• Development of Efficient siRNA Delivery System to Tumor Cells by Combining Octaarginine, GALA and Enzymatically-Cleavable PEG-Lipid

  Yu Sakurai; Hiroto Hatakeyama; Hidetaka Akita; Motoi Oishi; Yukio Nagasaki; Shiroh Futaki; Hideyoshi Harashima

  MOLECULAR THERAPY, May 2009

  
• Effects of a Serine Residue Introduced to Arginine‐containing α‐Peptide Ribonucleic Acids upon their Cell Membrane Permeability

  西尾明洋; 和田健彦; 福原学; YANG Cheng; 森直; 中瀬生彦; 二木史朗; 井上佳久

  日本化学会講演予稿集, 13 Mar. 2009

  
• 光架橋による細胞内ペプチドータンパク質相互作用の解析

  福田保則; 畑中保丸; 二木史朗

  第3１回日本分子生物学会年会・第8１回日本生化学会大会 合同大会 ,神戸, 11 Dec. 2008, Peer-reviewed

  
• マルチ亜鉛フィンガーのin vitro及びin celluloでの挙動相関

  森崎達也; 今西未来; 二木史朗; 杉浦幸雄

  第3１回日本分子生物学会年会・第8１回日本生化学会大会 合同大会 ,神戸, 09 Dec. 2008, Peer-reviewed

  
• 効率的に細胞内移行するアルギニンペプチドとその経路

  広瀬久昭; 武内敏秀; 中瀬生彦; 二木史朗

  第3１回日本分子生物学会年会・第8１回日本生化学会大会 合同大会 ,神戸, 09 Dec. 2008, Peer-reviewed

  
• Effects of arginine residue introduction upon interaction and complexation behavior of peptide ribonucleic acids (PRNAs) with RNA: synthesis and properties of alpha-containing arginine.

  T. Wada; N. Sawa; H. Sato; S. Futaki; Y. Inoue

  Nucleic acids symposium series (2004), 01 Dec. 2008

  
• iPS細胞に対する蛋白導入ドメインの有効性比較

  湯川 博; 野口洋文; 中瀬生彦; 宮本義孝; 大石幸一; 二木史朗; 林衆治

  第35回日本臓器保存生物医学会総会 ,東京, 22 Nov. 2008, Peer-reviewed

  
• Enhanced cell internalization of octaarginine by fatty acid modification

  片山沙綾香; 広瀬久昭; 二木史朗

  第45回 ペプチド討論会The 45th Japanese Peptide Symposium ,東京, 30 Oct. 2008, Peer-reviewed

  
• Facile One-Pot Modification with Oligoarginine for Intracellular Delivery

  Takayama K; Tadokoro A; Nakase I; Futaki S

  第45回 ペプチド討論会The 46th Japanese Peptide Symposium ,東京, 29 Oct. 2008, Peer-reviewed

  
• EFFICIENT CELLULAR UPTAKE OF FLOCK HOUSE VIRUS DERIVED PEPTIDE

  NAKASE Ikuhiko; HIROSE Hisaaki; FUTAKI Shiroh

  ペプチド討論会講演要旨集, 14 Oct. 2008, Peer-reviewed

  
• Artificial Zinc Finger-Type Transcription Factors Targeting Circadian Clock Genes

  Imanishi M; Nakamura A; Futaki S

  Chemistry in the New World of Bioengineering and Synthetic Biology ,Oxford, UK, 22 Sep. 2008, Peer-reviewed

  
• Ida修飾化システインを用いた金属応答性bZIPペプチドの創製とDNA結合スイッチ

  東 佑翼; 吉村 智之; 川端 猛夫; 二木史朗

  第3回バイオ関連化学合同シンポジウム ,横浜, 19 Sep. 2008, Peer-reviewed

  
• 時計遺伝子プロモーターに作用するジンクフィンガー型人工転写因子の創製

  今西未来; 今西未来; 中村篤史; 二木史朗

  日本化学会バイオテクノロジー部会シンポジウム講演要旨集, 08 Sep. 2008, Peer-reviewed

  
• Novel Intracellular Delivery System using pH-Dependent Fusiogenic Peptide

  Nakase I; Kobayashi S; Kawabata N; Futaki S

  30th European Peptide Symposium ,Helsinki, Finland, 02 Sep. 2008, Peer-reviewed

  
• Effective Macropinocytosis Induction and Membrane Penetration by FHV Peptide

  Nakase I; Hirose H; Takeuchi T; Futaki S

  Cell-Penetrating Peptides (CPP) Satellite Symposium of 30th European Peptide Symposium ,Helsinki, Finland, 31 Aug. 2008, Peer-reviewed

  
• FHVペプチドの効率的な膜透過機能

  中瀬生彦; 広瀬久昭; 二木史朗

  第30回生体膜と薬物の相互作用シンポジウム ,札幌, 08 Aug. 2008, Peer-reviewed

  
• フェニルボロン酸誘導体を塩基部配向規制内部因子とする新規ペプチドリボ核酸(PRNA)の合成とpHによる可逆的RNA錯体形成制御

  和田健彦; 西尾明洋; 澤展也; 佐藤博文; 二木史朗; 井上佳久

  バイオ・高分子シンポジウム講演要旨集, 18 Jul. 2008

  
• Rapid Cellular Uptake of Octaarginine-Based Peptides Bearing Hydrophobic Amino Acid Sequences

  Takayama K; Takayama K; Takeuchi T; Nakase I; Futaki S

  2nd International Symposium "Cellular Delivery of Therapeutic Macromolecules 2008" ,Cardiff, UK, 23 Jun. 2008, Peer-reviewed

  
• 金属イオンによる会合制御が可能なチャネル形成ペプチドの創製とその応用

  能代大輔; 浅見耕司; 二木史朗

  第18回金属の関与する生体関連反応シンポジウム（SRM2008） ,名古屋, 05 Jun. 2008, Peer-reviewed

  
• Ida-Co(II)錯形成を利用した人工金属応答性ロイシンジッパーの構造スイッチ

  東 佑翼; 吉村 智之; 川端 猛夫; 二木史朗

  第18回金属の関与する生体関連反応シンポジウム（SRM2008） ,名古屋, 05 Jun. 2008, Peer-reviewed

  
• GM2ガングリオシドーシスモデルマウスに対する組換えヒトβ‐ヘキソサミニダーゼの脳内補充効果

  辻大輔; 安岡寛子; 松岡和彦; 宮崎絵梨; 広瀬由記子; 明星裕美; 笠原由子; 千葉靖典; 地神芳文; 二木史朗; 櫻庭均; 伊藤孝司

  脂質生化学研究, 20 May 2008

  
• 膜透過ペプチドを用いた細胞内タンパク質相互作用解析

  中村保則; 兼田真樹; 武内敏秀; 畑中保丸; 二木史朗

  ケミカルバイオロジー研究会年会 ,東京, 20 May 2008, Peer-reviewed

  
• アルギニン含有α‐ペプチドリボ核酸とRNAとの錯体形成挙動に対するセリン導入効果

  和田健彦; 西尾明洋; 澤展也; 武内敏秀; 二木史朗; 井上佳久

  高分子学会予稿集(CD-ROM), 08 May 2008

  
• アルギニン含有α‐ペプチドリボ核酸とRNAとの錯体形成挙動に対するセリン導入効果

  西尾明洋; 澤展也; 和田健彦; 武内敏秀; 二木史朗; 森直; YANG Cheng; 井上佳久

  日本化学会講演予稿集, 12 Mar. 2008

  
• Efficient Internalization of Flock House Virus-derived Peptide into Living Cells

  HIROSE Hisaaki; TAKEUCHI Toshihide; NAKASE Ikuhiko; FUTAKI Shiroh

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2008

  
• A New Approach for Metal-induced Switch Using Modified Cysteines

  Azuma Y; Yoshimura T; Kawabata T; Futaki S

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2008, Peer-reviewed

  
• Cell penetrating peptideを用いた中枢神経系疾患に対するProtein therapyに関する基礎研究

  辻大輔; 広瀬由記子; 中瀬生彦; 二木史朗; 伊藤孝司

  生化学, 2008

  
• Cell penetrating peptideを用いたヒト保護タンパク/カテプシンAの細胞内補充効果の検討

  堀川靖; 辻大輔; 田口雅浩; 広瀬由記子; 二木史朗; 伊藤孝司

  生化学, 2008

  
• マルチ亜鉛フィンガー型人工転写因子による経時的転写活性化能の解析

  森崎達也; 今西未来; 二木史朗; 杉浦幸雄

  第30回日本分子生物学会年会・第80回日本生化学回大会合同大会 ,横浜, 12 Dec. 2007, Peer-reviewed

  
• オリゴアルギニンペプチド融合タンパクの細胞内局在解析

  広瀬 由記子; 広瀬由記子; 辻 大輔; 安岡寛子; 二木史郎; 伊藤孝司

  第30回日本分子生物学会年会・第80回日本生化学回大会合同大会 ,横浜, 11 Dec. 2007, Peer-reviewed

  
• Cell penetrating peptideを用いたヒトβ-ヘキソサミニダーゼの細胞内補充効果の検討

  安岡寛子; 辻 大輔; 広瀬由記子; 明星裕美; 千葉靖典; 地神芳文; 二木史郎; 桜庭 均; 伊藤孝司

  第30回日本分子生物学会年会・第80回日本生化学回大会合同大会 ,横浜, 11 Dec. 2007, Peer-reviewed

  
• 修飾システインを用いた金属応答性ペプチドの開発

  東 佑翼; 吉村智之; 川端 猛夫; 二木史朗

  第44回ペプチド討論会 ,富山, 08 Nov. 2007, Peer-reviewed

  
• フロックハウスウイルス由来ペプチドの効率的細胞内移行

  広瀬久昭; 武内敏秀; 中瀬生彦; 二木史朗

  第44回ペプチド討論会 ,富山, 08 Nov. 2007, Peer-reviewed

  
• キレート形成原子団導入によるアラメチシンの会合安定化

  能代大輔; 浅見孝司; 二木史朗

  第57回日本薬学会近畿支部大会 ,高槻, 27 Oct. 2007, Peer-reviewed

  
• プロモーターを標的とする人工マルチ亜鉛フィンガータンパク質の創製：モチーフの連結によるDNA結合性への影響

  中村篤史; 今西未来; 二木史朗

  第57回日本薬学会近畿支部大会 ,高槻, 27 Oct. 2007, Peer-reviewed

  
• カチオン性脂質とpH感受性ペプチドによるタンパク質の効率的細胞内導入

  小林祥子; 川畑紀子; 中瀬生彦; 二木史朗

  第57回日本薬学会近畿支部大会 ,高槻, 27 Oct. 2007, Peer-reviewed

  
• 高効率に細胞内移行するFHVペプチドの機能評価

  広瀬久昭; 武内敏秀; 中瀬生彦; 二木史朗

  第57回日本薬学会近畿支部大会 ,高槻, 27 Oct. 2007, Peer-reviewed

  
• DESIGN OF PHOSPHOPEPTIDES BEARING PHOTO-CROSS-LINKER FOR THE ANALYSIS OF IN-CELL PROTEIN RECOGNITION

  NAKAMURA Yasunori; KANEDA Masaki; TAKEUCHI Toshihide; HATANAKA Yasumaru; FUTAKI Shiroh

  ペプチド討論会講演要旨集, 15 Oct. 2007, Peer-reviewed

  
• 金属イオンによるチャネル形成ペプチドの会合安定化 Metal-mediated stabilization of channel peptide assemblies

  能代大輔; 浅見孝司; 二木史朗

  第22回生体機能関連化学シンポジウム ,仙台, 28 Sep. 2007, Peer-reviewed

  
• アルギニンペプチドの細胞移行機序の濃度依存性

  二木史朗; 武内敏秀; 小管通江; 中瀬生彦

  第22回生体機能関連化学シンポジウム ,仙台, 28 Sep. 2007, Peer-reviewed

  
• カチオン性脂質共存下におけるpH感受性ペプチドの細胞内移行促進

  小林祥子; 川畑紀子; 中瀬生彦; 二木史朗

  第22回生体機能関連化学シンポジウム ,仙台, 28 Sep. 2007, Peer-reviewed

  
• アルギニンを分子内に有するα‐ペプチドリボ核酸(PRNA)の合成とRNAとの相互作用

  西尾明洋; 和田健彦; 森直; 二木史朗; 井上佳久

  生体機能関連化学シンポジウム講演要旨集, 10 Sep. 2007

  
• アルギニン導入α‐ペプチドリボ核酸(α‐PRNA)の合成とDNAとの相互作用ならびに細胞導入効率の検討

  和田健彦; 西尾明洋; 澤展也; 佐藤博文; 二木史朗; 井上佳久

  バイオ・高分子シンポジウム講演要旨集, 23 Jul. 2007

  
• Linker design of multiple zinc finger peptides: flexible, polycationic, and metal-binding looped linkers

  IMANISHI Miki; YAN Wei; FUTAKI Shiroh; SUGIURA Yukio

  金属の関与する生体関連反応シンポジウム講演要旨集, 01 Jun. 2007, Peer-reviewed

  
• An Oligoarginine-Based Cargo-Transporter System for Improving Drug Intestinal Absorption: Utilization of Self-Cleavable Peptide Linkers

  Takayama K; Hayashi Y; Suehisa Y; Fujita T; Yamamoto A; Futaki S; Kiso Y

  Cell penetrating peptides: A Biochemical Society Focused Meeting ,Telford, UK, 11 May 2007, Peer-reviewed

  
• aヘリックスリンカーが人工6-亜鉛フィンガーペプチドのDNA 結合に及ぼす影響

  閻 薇; 今西未来; 二木史朗; 杉浦幸雄

  日本ケミカルバイオロジー研究会 第2回年会 ,京都, 10 May 2007, Peer-reviewed

  
• 金属を認識する人工受容体型チャネルタンパク質の設計 Designing Artificial Metal-gated Ion Channels

  能代大輔; 園田和弘; 東野俊介; 浅見孝司; 二木史朗

  日本ケミカルバイオロジー研究会 第2回年会 ,京都, 10 May 2007, Peer-reviewed

  
• 膜透過性アルギニンペプチド：細胞による効率的な取り込みとプロテオグリカン依存性

  中瀬生彦; 田所明子; 武内敏秀; 二木史朗

  日本ケミカルバイオロジー研究会 第2回年会 ,京都, 10 May 2007, Peer-reviewed

  
• Creation of artificial zinc finger type transcription factors

  中村篤史; 今西未来; 二木史朗

  日本ケミカルバイオロジー研究会 第2回年会 ,京都, 09 May 2007, Peer-reviewed

  
• アルギニン導入α‐ペプチドリボ核酸(α‐PRNA)の合成と細胞導入の検討

  西尾明洋; 和田健彦; 森直; 二木史朗; 井上佳久

  日本化学会講演予稿集, 12 Mar. 2007

  
• オリゴアルギニンペプチド融合タンパクの細胞内導入機構解析

  辻大輔; 広瀬由記子; 安岡寛子; 二木史朗; 伊藤孝司

  生化学, 2007

  
• Effect of peptide concentration and serum on the modes of internalization of arginine-rich peptides

  Shiroh Futaki; Toshihide Takeuchi; Michie Kosuge; Ikuhiko Nakase

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2007, Peer-reviewed

  
• RNA recognition and recognition control of alpha-peptide ribonucleic acids containing arginine residue by external factors.

  T. Wada; Y. Maeda; N. Sawa; H. Sato; S. Futaki; Y. Inoue

  Nucleic acids symposium series (2004), 01 Dec. 2006

  
• 膜透過ペプチドを用いた細胞内デリバリー

  二木史朗

  徳島大学大学院ヘルスバイオサイエンス研究部講義 ,徳島, 02 Jun. 2006, Peer-reviewed

  
• Uptake mechanisms of FITC-oligoarginine conjugates in HeLa cells.

  Yuka Suehisa; Kentaro Takayama; Mamiko Hayashi; Shiroh Futaki; Akira Yamamoto; Yoshio Hayashi; Yoshiaki Kiso; Takuya Fujita

  Peptide Science 2006, 2006

  
• Design and synthesis of oligoarginine-fluorescein conjugates possessing novel self-cleavable spacers as a model for effective intestinal absorption.

  Yoshio Hayashi; Kentaro Takayama; Yuka Suehisa; Takuya Fujita; Akira Yamamoto; Shiroh Futaki; Yoshiaki Kiso

  Peptide Science 2006, 2006

  
• Synthesis of Nonplanar Peptides Bearing the 7-Azabicyclo[2. 2. 1]heptane Skeleton, and the Possible Self-organized Structures

  OTANI Yuko; FUTAKI Shiroh; KIWADA Tatsuto; SUGIURA Yukio; OHWADA Tomohiko

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2005

  
• Characterization of the Cellular Uptake of Arginine-rich Peptides

  FUTAKI Shiroh; NAKASE Ikuhiko; NIWA Miki; TAKEUCHI Toshihide; SUGIURA Yukio; SIMPSON Jeremy C.; JONES Arwyn T.

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2005

  
• Fe(III)-mediated Modulation of Peptide Structure and Recognition

  FUTAKI Shiroh; KIWADA Tatsuto; SUGIURA Yukio

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2005

  
• Control of peptide structure and function by Fe(II)-induced helix destabilization

  S Futaki; T Kiwada; Y Sugiura

  BIOPOLYMERS, 2005

  
• Effect of counteranions and membrane potential on the cellular uptake of arginine-rich peptides

  T Takeuchi; Nakase, I; Y Sugiura; N Sakai; S Matile; S Futaki

  BIOPOLYMERS, 2005

  
• Development of a Novel Non-Viral DNA Vaccine-Delivering Gene into the Nucleus of Dendritic Cells.

  Nakamra T; Kogure K; Moriguchi R; Futaki S; Fujimuro M; Yokosawa H; Seya T; Harashima H

  Mol.Therapy, 2005

  
• PEG修飾リポソームの細胞内動態制御の検討

  茶木伸治; 小暮健太朗; 二木史朗; 丸山一雄; 原島秀吉

  Drug Deliv Syst, 10 May 2004

  
• ARGININE-RICH PEPTIDES: THE STRUCTURES AND MANNERS OF INTERNALIZATION

  S. Futaki; I. Nakase; T. Takeuchi; M. Niwa; J. C. Simpson; A. T. Jones; Y. Sugiura

  JOURNAL OF PEPTIDE SCIENCE, 2004

  
• Cholesteryl‐GALA導入トランスフェリン修飾リポソームの細胞内動態の解析

  茶木伸治; 角道智行; 中瀬生彦; 丸山一雄; 二木史朗; 紙谷浩之; 原島秀吉

  Drug Deliv Syst, 10 May 2003

  
• Oligoarginine-mediated Delivery of Bioactive Peptides into Living cells

  FUTAKI Shiroh; NAKASE Ikuhiko; NIWA Miki; SUZUKI Tomoki; NAMEKI Daisuke; KODAMA Ei-ichi; MATSUOKA Masao; SUGIURA Yukio

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Feb. 2003

  
• Application of oligoarginine for the delivery of protein complexes into living cells

  S Futaki; Nakase, I; M Niwa; T Suzuki; D Nameki; EL Kodama; M Matsuoka; Y Sugiura

  BIOPOLYMERS, 2003

  
• Mechanism of improved gene transfer by the N-terminal stearylation of octaarginine

  Khalil I.A.; 馬場 嘉信; 二木 史朗; 紙谷 浩之; 原島 秀吉

  日本薬物動態学会年会講演要旨集, 2003

  
• Arginine‐richペプチドを用いたRNase S複合体の細胞内導入

  FUTAKI SHIROH; NAKASE ARIHIKO; SUZUKI TOMOKI; NIWA MIKI; NAMEKI DAISUKE; KODAMA EIICHI; MATSUOKA MASAO; SUGIURA YUKIO

  日本薬学会年会要旨集, 05 Mar. 2002

  
• arginine-richペプチドの膜透過における硫酸化多糖の関与

  鈴木 智樹; 二木 史朗; 丹羽 美紀; 中瀬 生彦; 田中 静吾; 上田 國寛; 杉浦 幸雄

  日本薬学会年会要旨集, Mar. 2002

  
• Involvement of Sulfated Glycosaminoglycans with the Internalization of Basic Peptides

  Suzuki T; Futaki S; Niwa M; Nakase I; Tanaka S; Ueda K; Sugiura Y

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2002, Peer-reviewed

  
• GALAによるTf‐修飾リポソームの細胞内動態の解析

  角道智行; 茶木伸治; 中瀬生彦; 丸山一雄; 二木史朗; 紙谷浩之; 原島秀吉

  生体膜と薬物の相互作用シンポジウム講演要旨集, 08 Nov. 2001

  
• 共焦点レーザー顕微鏡によるTF‐リポソームの細胞内動態の解析とその制御

  茶木伸治; 紙谷浩之; 角道智行; 二木史朗; 丸山一雄; 松岡一郎; 原島秀吉

  Drug Deliv Syst, 10 Jul. 2001

  
• 細胞膜透過能を有するarginine-richペプチドの膜透過効率と細胞選択性

  鈴木 智樹; 大橋 若奈; 中瀬 生彦; 田中 静吾; 上田 國寛; 二木 史朗; 杉浦 幸雄

  日本薬学会年会要旨集, Mar. 2001

  
• Stability and self association of a model transmembrane helix in lipid bilayers

  Y Yano; T Takemoto; S Kobayashi; W Ohashi; M Niwa; S Futaki; Y Sugiura; K Matsuzaki

  BIOPHYSICAL JOURNAL, Jan. 2001

  
• 人工金属フィンガーモチーフの設計 H4型配位構造を有する新規亜鉛フィンガー

  堀雄一郎; 鈴木教夫; 奥野恭史; 永岡真; 二木史朗; 杉浦幸雄

  日本薬学会年会要旨集, 05 Mar. 2000

  
• The engineering, structure, and DNA binding properties of a novel His4-type zinc finger peptide.

  Y. Hori; K. Suzuki; Y. Okuno; M. Nagaoka; S. Futaki; Y. Sugiura

  Nucleic acids symposium series, 01 Jan. 2000

  
• リポソームによる高分子医薬品の細胞内動態制御法に関する研究(1)

  橘 理恵子; 太田 慈子; 庄野 正行; 二木 史郎; 篠原 康雄; 原島 秀吉; 際田 弘志

  薬剤学, 05 Mar. 1998

  
• pH-感受性リポソームによる核局在化シグナル修飾アルブミンの細胞内動態制御法の開発

  橘 理恵子; 原島 秀吉; 際田 弘志; 庄野 正行; 東野 満喜子; 二木 史朗

  薬物動態 = Xenobiotic metabolism and disposition, 09 Oct. 1997

  
• Control of intracellular disposition of liposomally encapsulated FITC-albumin in macrophages

  R. Tachibana; H. Harashima; S. Futaki; M. Shono; H. Kiwada

  Proceedings of the Controlled Release Society, 01 Jan. 1997

  
• STUDIES ON PEPTIDES .132. EVALUATION OF 2 BETA-CARBOXYL PROTECTING GROUPS OF ASPARTIC-ACID, CYCLOHEPTYL AND CYCLOOCTYL, FOR PEPTIDE-SYNTHESIS

  N FUJII; M NOMIZU; S FUTAKI; A OTAKA; S FUNAKOSHI; K AKAJI; K WATANABE; H YAJIMA

  CHEMICAL & PHARMACEUTICAL BULLETIN, Feb. 1986

  
• ペプチドに関する研究(C2012) ペプチド合成におけるアスパラギン酸のβ-カルボキシル基の2つの保護基cycloheptyl及びcyclooctyl estersの有用性

  藤井 信孝; 野水 基義; 二木 史朗

  Chemical & Pharmaceutical Bulletin, Feb. 1986

  
• NIN-MESITYLENE-2-SULFONYLTRYPTOPHAN, A NEW TRYPTOPHAN DERIVATIVE, AND ITS APPLICATION FOR PEPTIDE-SYNTHESIS

  N FUJII; S FUTAKI; K YASUMURA; K AKAJI; H YAJIMA

  HETEROCYCLES, 1984