Basic Information

Faculty

• 薬学部

Concurrent Affiliation

• Graduate School of Pharmaceutical Sciences, 医薬創成情報科学専攻 システムバイオロジー分野, 教授

Professional Memberships

• 日本薬学会
• 日本分子生物学会
• 日本内分泌学会
• 日本時間生物学会
• 日本神経科学会
• 日本生化学会

Academic Degree

• 修士（理学）(東京大学)
• 博士（理学）(東京大学)

Academic Resume (Graduate Schools)

• 東京大学, 大学院理学系研究科修士課程生物化学専攻, 修了
• 東京大学, 大学院理学系研究科博士後期課程生物化学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 東京大学, 理学部生物化学科, 卒業

High School

• High School

  私立灘高等学校

Research History

• From Apr. 2018, To Present

  Kyoto University, Graduate School of Pharmaceutical Sciences, 教授
• From Jan. 2011, To Mar. 2018

  京都大学 薬学研究科(研究院) 准教授
• From 2008, To 2011

  京都大学 薬学研究科(研究院), 講師
• From 2007, To 2009

  京都大学 薬学研究科, 講師
• From 2006, To 2007

  神戸大学 医学(系)研究科(研究院), 助手
• From 01 Jan. 2011

  -, -
• From 01 Apr. 2004

  -, -
• From 01 Apr. 2003

  -, -
• From 01 Apr. 2002

  -, -

Language of Instruction

• English

ID,URL

• ORCID ID

  0000-0001-6264-9217

• J-Global ID

  201101085704492210

• External link

  http://systems-biology.pharm.kyoto-u.ac.jp/

Website(s) (URL(s))

• http://systems-biology.pharm.kyoto-u.ac.jp/

researchmap URL

• https://researchmap.jp/doimasao

Research

Research Topics, Overview of the research

• Research Topics

  Research and Development of Innovative Chronotherapy and Diagnosis Based on Biological Clock

• Overview of the research

  Given the increasing prevalence of sleep disorders, rotating shift work, and irregular nocturnal lifestyles in our society today, it is important to elucidate how body clock disturbances affect human health and disease. The missions of my lab study include the development of drugs able to tune the internal body time as well as the creation of new mechanism-based diagnostics and therapeutic interventions against the diseases caused by the body clock disturbances. We prospect that these works will change preexisting disease concepts and generate new treatment strategies based on the molecular clock.

Research Interests

• イントラクライン
• 翻訳制御
• 老化
• G蛋白質制御因子
• 視交叉上核
• 生体リズム
• 薬理学
• 転写制御
• 高血圧
• 神経科学
• 時計遺伝子
• サーカディアンリズム
• Steroid
• G-protien coupled receptor
• Adult lifestyl-related disease

Research Areas

• Life sciences, Pharmacology
• Life sciences, Pharmaceuticals - health and biochemistry
• Life sciences, Functional biochemistry
• Life sciences, Neuroscience - general

Papers

• Identification of angiotensin II-responsive circadian clock gene expression in adrenal zona glomerulosa cells and human adrenocortical H295R cells

  Tomohiro Otani; Takahito Miyake; Takumi Ota; Daisuke Yarimizu; Yuuki Nakagawa; Iori Murai; Hitoshi Okamura; Emi Hasegawa; Masao Doi

  Frontiers in Endocrinology, 26 Mar. 2025, Peer-reviewed, Last author, Corresponding author

  
• Circadian Clock and Body Temperature

  Takahito Miyake; Yuichi Inoue; Yota Maekawa; Masao Doi

  Advances in Experimental Medicine and Biology, 18 Sep. 2024, Peer-reviewed, Last author, Corresponding author

  
• Identification of meibomian gland testosterone metabolites produced by tissue-intrinsic intracrine deactivation activity

  Khanh Tien Nguyen Pham; Takahito Miyake; Tomo Suzuki; Shigeru Kinoshita; Yuki Hamada; Hikari Uehara; Mamiko Machida; Takeshi Nakajima; Emi Hasegawa; Masao Doi

  iScience, Feb. 2025, Peer-reviewed, Last author, Corresponding author

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• Size-reduced DREADD derivatives for AAV-assisted multimodal chemogenetic control of neuronal activity and behavior.

  Takahito Miyake; Kaho Tanaka; Yutsuki Inoue; Yuji Nagai; Reo Nishimura; Takehito Seta; Shumpei Nakagawa; Ken-Ichi Inoue; Emi Hasegawa; Takafumi Minamimoto; Masao Doi

  Cell reports methods, 21 Oct. 2024, Peer-reviewed, Last author, Corresponding author

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• Circuits involving the hypothalamic suprachiasmatic nucleus for controlling diverse physiologies verified by the aid of optogenetics and chemogenetics

  Sui-Wen Hsiao; Masao Doi

  International Review of Cell and Molecular Biology, 2024, Peer-reviewed, Last author, Corresponding author

  
• d-Alanine Affects the Circadian Clock to Regulate Glucose Metabolism in Kidney.

  Shinsuke Sakai; Youichi Tanaka; Yusuke Tsukamoto; Shihoko Kimura-Ohba; Atsushi Hesaka; Kenji Hamase; Chin-Ling Hsieh; Eiryo Kawakami; Hiraku Ono; Kotaro Yokote; Mitsuaki Yoshino; Daisuke Okuzaki; Hiroyo Matsumura; Atsuko Fukushima; Masashi Mita; Maiko Nakane; Masao Doi; Yoshitaka Isaka; Tomonori Kimura

  Kidney360, 15 Dec. 2023

  
• Reactivation of circadian clock-regulated intracrine activity ameliorates meibomian gland dysfunction and its associated dry eye disease

  Hikari Uehara; Masao Doi

  SSBR Proceedings, volume ’Circadian Clocks’ edited by Honma K and Honma S, Hokkaido University Press, 2023

  
• Omeprazole Induces CYP3A4 mRNA Expression but Not CYP3A4 Protein Expression in HepaRG Cells

  Yuto Fujita; Takahito Miyake; Xinyan Shao; Yuto Aoki; Emi Hasegawa; Masao Doi

  Biological and Pharmaceutical Bulletin, 27 Jun. 2024, Peer-reviewed, Last author, Corresponding author

  
• Temperature-Dependent Upregulation of Per2 Protein Expression Is Mediated by eIF2α Kinases PERK and PKR through PI3K Activation

  Xinyan Shao; Takahito Miyake; Yuichi Inoue; Emi Hasegawa; Masao Doi

  Biological and Pharmaceutical Bulletin, 05 Mar. 2024, Peer-reviewed, Last author, Corresponding author

  
• An intact pituitary vasopressin system is critical for building a robust circadian clock in the suprachiasmatic nucleus.

  Yoshiaki Yamaguchi; Yota Maekawa; Kyohei Kabashima; Takanobu Mizuno; Motomi Tainaka; Toru Suzuki; Kumiko Dojo; Takeichiro Tominaga; Sayaka Kuroiwa; Satoru Masubuchi; Masao Doi; Keiko Tominaga; Kazuto Kobayashi; Satoshi Yamagata; Keiichi Itoi; Manabu Abe; William J Schwartz; Kenji Sakimura; Hitoshi Okamura

  Proceedings of the National Academy of Sciences of the United States of America, 24 Oct. 2023

  
• Calibrated ribosome profiling assesses the dynamics of ribosomal flux on transcripts.

  Kotaro Tomuro; Mari Mito; Hirotaka Toh; Naohiro Kawamoto; Takahito Miyake; Siu Yu A Chow; Masao Doi; Yoshiho Ikeuchi; Yuichi Shichino; Shintaro Iwasaki

  Nature communications, 26 Aug. 2024

  
• The identification of novel small extracellular vesicle (sEV) production modulators using luciferase‐based sEV quantification method

  Aki Yamamoto; Yuki Takahashi; Shinsuke Inuki; Shumpei Nakagawa; Kodai Nakao; Hiroaki Ohno; Masao Doi; Yoshinobu Takakura

  Journal of Extracellular Biology, Sep. 2022, Peer-reviewed

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• Minimal upstream open reading frame of Per2 mediates phase fitness of the circadian clock to day/night physiological body temperature rhythm.

  Takahito Miyake; Yuichi Inoue; Xinyan Shao; Takehito Seta; Yuto Aoki; Khanh Tien Nguyen Pham; Yuichi Shichino; Junko Sasaki; Takehiko Sasaki; Masahito Ikawa; Yoshiaki Yamaguchi; Hitoshi Okamura; Shintaro Iwasaki; Masao Doi

  Cell reports, 28 Feb. 2023, Peer-reviewed, Last author, Corresponding author

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• Optimising the method for visualising mouse meibomian gland using eyelid whole-mount lipid staining.

  Yuki Hamada; Lena Sasaki; Hikari Uehara; Tomo Suzuki; Shigeru Kinoshita; Kento Otsuka; Akio Kihara; Yoshiaki Yamaguchi; Takahito Miyake; Masao Doi

  The ocular surface, 06 Oct. 2022, Peer-reviewed, Last author, Corresponding author

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• Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity.

  Yoshiaki Yamaguchi; Iori Murai; Momoko Takeda; Shotaro Doi; Takehito Seta; Reiko Hanada; Kenji Kangawa; Hitoshi Okamura; Takahito Miyake; Masao Doi

  Biological & pharmaceutical bulletin, 2022, Peer-reviewed, Last author, Corresponding author

  
• Circadian protection against bacterial skin infection by epidermal CXCL14-mediated innate immunity

  Kojiro Tsujihana; Kosuke Tanegashima; Yasuko Santo; Hiroyuki Yamada; Sota Akazawa; Ryuta Nakao; Keiko Tominaga; Risa Saito; Yasumasa Nishito; Ryu-Ichiro Hata; Tomonori Nakamura; Iori Murai; Yuka Kono; Maho Sugawa; Miki Tanioka; Gyohei Egawa; Masao Doi; Tadashi Isa; Kenji Kabashima; Takahiko Hara; Hitoshi Okamura

  Proceedings of the National Academy of Sciences, 21 Jun. 2022, Peer-reviewed

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• A light-induced small G-protein gem limits the circadian clock phase-shift magnitude by inhibiting voltage-dependent calcium channels.

  Masahiro Matsuo; Kazuyuki Seo; Akiyuki Taruno; Yasutaka Mizoro; Yoshiaki Yamaguchi; Masao Doi; Rhyuta Nakao; Hiroshi Kori; Takaya Abe; Harunori Ohmori; Keiko Tominaga; Hitoshi Okamura

  Cell reports, 24 May 2022, Peer-reviewed

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• Intracrine activity involving NAD-dependent circadian steroidogenic activity governs age-associated meibomian gland dysfunction

  Lena Sasaki; Yuki Hamada; Daisuke Yarimizu; Tomo Suzuki; Hiroki Nakamura; Aya Shimada; Khanh Tien; Nguyen Pham; Xinyan Shao; Koki Yamamura; Tsutomu Inatomi; Hironobu Morinaga; Emi K. Nishimura; Fujimi Kudo; Ichiro Manabe; Shogo Haraguchi; Yuki Sugiura; Makoto Suematsu; Shigeru Kinoshita; Mamiko Machida; Takeshi Nakajima; Hiroshi Kiyonari; Hitoshi Okamura; Yoshiaki Yamaguchi; Takahito Miyake; Masao Doi

  Nature Aging, Feb. 2022, Peer-reviewed, Last author, Corresponding author

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• [Roles of the Circadian Clock Mechanism in the Regulation of Daily Rhythms of Body Temperature].

  Takahito Miyake; Masao Doi

  Brain and nerve = Shinkei kenkyu no shinpo, Feb. 2022

  
• Gpr19 is a circadian clock-controlled orphan GPCR with a role in modulating free-running period and light resetting capacity of the circadian clock.

  Yoshiaki Yamaguchi; Iori Murai; Kaoru Goto; Shotaro Doi; Huihua Zhou; Genzui Setsu; Hiroyuki Shimatani; Hitoshi Okamura; Takahito Miyake; Masao Doi

  Scientific reports, 17 Nov. 2021, Peer-reviewed, Last author, Corresponding author

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• Thermographic imaging of mouse across circadian time reveals body surface temperature elevation associated with non-locomotor body movements

  Hiroyuki Shimatani; Yuichi Inoue; Yota Maekawa; Takahito Miyake; Yoshiaki Yamaguchi; Masao Doi

  PLOS ONE, 28 May 2021, Peer-reviewed, Last author, Corresponding author

  
• Role of α2δ3 in Cellular Synchronization of the Suprachiasmatic Nucleus Under Constant Light Conditions

  Masahiro Matsuo; Kazuyuki Seo; Naoki Mizuguchi; Fumiyoshi Yamazaki; Shoichi Urabe; Naoto Yamada; Masao Doi; Keiko Tominaga; Hitoshi Okamura

  Neuroscience, May 2021

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• Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver

  Heng Lin; Yen-Sung Huang; Jean-Michel Fustin; Masao Doi; Huatao Chen; Hui-Huang Lai; Shu-Hui Lin; Yen-Lurk Lee; Pei-Chih King; Hsien-San Hou; Hao-Wen Chen; Pei-Yun Young; Hsu-Wen Chao

  Nature Communications, 24 Aug. 2020, Peer-reviewed

  
• Time-Restricted G-Protein Signaling Pathways via GPR176, Gz, and RGS16 Set the Pace of the Master Circadian Clock in the Suprachiasmatic Nucleus

  Shumpei Nakagawa; Khanh Tien Nguyen Pham; Xinyan Shao; Masao Doi

  International Journal of Molecular Sciences, 17 Jul. 2020, Peer-reviewed, Last author, Corresponding author

  
• Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176.

  Masao Doi

  Scientific reports, 10 Mar. 2020, Peer-reviewed, Last author, Corresponding author

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• Reconstitution of Organismal Liver Clock Function Requires Light

  Masao Doi

  Trends in Endocrinology & Metabolism, Sep. 2019, Peer-reviewed, Last author, Corresponding author

  
• Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity.

  Masao Doi; Hiroyuki Shimatani; Yuta Atobe; Iori Murai; Hida Hayashi; Yukari Takahashi; Jean-Michel Fustin; Yoshiaki Yamaguchi; Hiroshi Kiyonari; Nobuya Koike; Kazuhiro Yagita; Choogon Lee; Manabu Abe; Kenji Sakimura; Hitoshi Okamura

  Nature communications, 12 Jun. 2019, Peer-reviewed, Lead author, Corresponding author

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• Fetal Leydig cells dedifferentiate and serve as adult Leydig stem cells.

  Yuichi Shima; Kanako Miyabayashi; Tetsuya Sato; Mikita Suyama; Yasuyuki Ohkawa; Masao Doi; Hitoshi Okamura; Kentaro Suzuki

  Development (Cambridge, England), 05 Dec. 2018, Peer-reviewed

  
• Circadian coordination of ATP release in the urothelium via connexin43 hemichannels

  Atsushi Sengiku; Masakatsu Ueda; Jin Kono; Takeshi Sano; Nobuyuki Nishikawa; Sumihiro Kunisue; Kojiro Tsujihana; Louis S. Liou; Akihiro Kanematsu; Shigeki Shimba; Masao Doi; Hitoshi Okamura; Osamu Ogawa; Hiromitsu Negoro

  Scientific Reports, 01 Dec. 2018, Peer-reviewed

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• Correction: Two Ck1δ transcripts regulated by m6A meth-ylation code for two antagonistic kinases in the control of the circadian clock (Proceedings of the National Academy of Sciences of the United States of America (2018) 115 (5980-5985) DOI: 10.1073/pnas.1721371115)

  Jean Michel Fustin; Rika Kojima; Kakeru Itoh; Hsin Yi Chang; Shiqi Ye; Bowen Zhuang; Asami Oji; Shingo Gibo; Rajesh Narasimamurthy; David Virshup; Gen Kurosawa; Masao Doi; Ichiro Manabe; Yasushi Ishihama; Masahito Ikawa; Hitoshi Okamura

  Proceedings of the National Academy of Sciences of the United States of America, 03 Jul. 2018

  
• Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock

  Jean-Michel Fustin; Rika Kojima; Kakeru Itoh; Hsin-Yi Chang; Ye Shiqi; Bowen Zhuang; Asami Oji; Shingo Gibo; Rajesh Narasimamurthy; David Virshup; Gen Kurosawa; Masao Doi; Ichiro Manabe; Yasushi Ishihama; Masahito Ikawa; Hitoshi Okamura

  Proceedings of the National Academy of Sciences of the United States of America, 05 Jun. 2018, Peer-reviewed

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• Gm7325 Transcription Is Regulated by MyoD in Activated Muscle Satellite Cells

  Daisuke Takei; Miyuki Nishi; So-ichiro Fukada; Masao Doi; Hitoshi Okamura; Akiyoshi Uezumi; Lidan Zhang; Morikatsu Yoshida; Mikiya Miyazato; Atsuhiko Ichimura; Hiroshi Takeshima

  Biophysical Journal, Feb. 2018, Peer-reviewed

  
• Calcitonin receptors are ancient modulators for rhythms of preferential temperature in insects and body temperature in mammals

  Tadahiro Goda; Masao Doi; Yujiro Umezaki; Iori Murai; Hiroyuki Shimatani; Michelle L. Chu; Victoria H. Nguyen; Hitoshi Okamura; Fumika N. Hamada

  Genes and Development, 15 Jan. 2018, Peer-reviewed

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• Circadian PER2 protein oscillations do not persist in cycloheximide-treated mouse embryonic fibroblasts in culture

  Motomi Tainaka; Masao Doi; Yuichi Inoue; Iori Murai; Hitoshi Okamura

  Chronobiology International, 02 Jan. 2018, Peer-reviewed

  
• Circadian rhythms of micturition during jet lag

  Kakeru Ito; Miho Yasuda; Yuki Maeda; Jean-Michel Fustin; Yoshiaki Yamaguchi; Yuka Kono; Hiromitsu Negoro; Akihiro Kanematsu; Osamu Ogawa; Masao Doi; Hitoshi Okamura

  Biomedical Research (Japan), 2018, Peer-reviewed

  
• Effect of daily light on c-Fos expression in the suprachiasmatic nucleus under jet lag conditions

  Yulin Chen; Yoshiaki Yamaguchi; Toru Suzuki; Masao Doi; Hitoshi Okamura

  Acta Histochemica et Cytochemica, 2018, Peer-reviewed

  
• Circadian clock regulates hepatic polyploidy by modulating Mkp1-Erk1/2 signaling pathway

  Hsu-Wen Chao; Masao Doi; Jean-Michel Fustin; Huatao Chen; Kimihiko Murase; Yuki Maeda; Hida Hayashi; Rina Tanaka; Maho Sugawa; Naoki Mizukuchi; Yoshiaki Yamaguchi; Jun-ichirou Yasunaga; Masao Matsuoka; Mashito Sakai; Michihiro Matsumoto; Shinshichi Hamada; Hitoshi Okamura

  NATURE COMMUNICATIONS, Dec. 2017, Peer-reviewed

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• G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock

  Kaoru Goto; Masao Doi; Tianyu Wang; Sumihiro Kunisue; Iori Murai; Hitoshi Okamura

  ENDOCRINE JOURNAL, Jun. 2017, Peer-reviewed

  
• Carbachol Induces Phase-dependent Phase Shifts of Per1 Transcription Rhythms in Cultured Suprachiasmatic Nucleus Slices

  Kumiko Dojo; Yoshiaki Yamaguchi; Jean-Michel Fustin; Masao Doi; Masaki Kobayashi; Hitoshi Okamura

  JOURNAL OF BIOLOGICAL RHYTHMS, Apr. 2017, Peer-reviewed

  
• Gm7325 is MyoD-dependently expressed in activated muscle satellite cells

  Daisuke Takei; Miyuki Nishi; So-ichiro Fukada; Masao Doi; Hitoshi Okamura; Akiyoshi Uezumi; Lidan Zhang; Morikatsu Yoshida; Mikiya Miyazato; Atsuhiko Ichimura; Hiroshi Takeshima

  BIOMEDICAL RESEARCH-TOKYO, 2017, Peer-reviewed

  
• G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock

  Kaoru Goto; Masao Doi; Tianyu Wang; Sumihiro Kunisue; Iori Murai; Hitoshi Okamura

  Endocrine Journal, 2017, Peer-reviewed

  
• Clock genes and salt-sensitive hypertension: a new type of aldosterone-synthesizing enzyme controlled by the circadian clock and angiotensin II

  Hitoshi Okamura; Masao Doi; Kaoru Goto; Rika Kojima

  HYPERTENSION RESEARCH, Oct. 2016, Peer-reviewed

  
• Real-Time Recording of Circadian Per1 and Per2 Expression in the Suprachiasmatic Nucleus of Freely Moving Rats

  Yoshiaki Yamaguchi; Kazuki Okada; Takanobu Mizuno; Takumi Ota; Hiroyuki Yamada; Masao Doi; Masaki Kobayashi; Hajime Tei; Yasufumi Shigeyoshi; Hitoshi Okamura

  JOURNAL OF BIOLOGICAL RHYTHMS, Feb. 2016, Peer-reviewed

  
• Gpr176 is a Gz-linked orphan G-protein-coupled receptor that sets the pace of circadian behaviour

  Masao Doi; Iori Murai; Sumihiro Kunisue; Genzui Setsu; Naohiro Uchio; Rina Tanaka; Sakurako Kobayashi; Hiroyuki Shimatani; Hida Hayashi; Hsu-Wen Chao; Yuuki Nakagawa; Yukari Takahashi; Yunhong Hotta; Jun-ichirou Yasunaga; Masao Matsuoka; Michael H. Hastings; Hiroshi Kiyonari; Hitoshi Okamura

  NATURE COMMUNICATIONS, Feb. 2016, Peer-reviewed

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• Reply to comments to "letter to the Editor: Comment on Azmahani et al. steroidogenic enzymes, their related transcription factors and nuclear receptors in human sebaceous glands under normal and pathological conditions"

  Abdullah Azmahani; Yasuhiro Nakamura; Saulo J.A. Felizola; Yohei Ozawa; Kazue Ise; Takayoshi Inoue; Keely M. McNamara; Masao Doi; Hitoshi Okamura; Christos C. Zouboulis; Setsuya Aiba; Hironobu Sasano

  Journal of Steroid Biochemistry and Molecular Biology, 01 Jan. 2016, Peer-reviewed

  
• Stimulus-selective induction of the orphan nuclear receptor NGFIB underlies different influences of angiotensin II and potassium on the human adrenal gland zona glomerulosa-specific 3 beta-HSD isoform gene expression in adrenocortical H295R cells

  Daisuke Yarimizu; Masao Doi; Takumi Ota; Hitoshi Okamura

  ENDOCRINE JOURNAL, Sep. 2015, Peer-reviewed

  
• Stimulus-selective induction of the orphan nuclear receptor NGFIB underlies different influences of angiotensin II and potassium on the human adrenal gland zona glomerulosa-specific 3 beta-HSD isoform gene expression in adrenocortical H295R cells

  Daisuke Yarimizu; Masao Doi; Takumi Ota; Hitoshi Okamura

  ENDOCRINE JOURNAL, Sep. 2015, Peer-reviewed

  
• 3 beta-hydroxysteroid dehydrogenase isoforms in human aldosterone-producing adenoma

  Sachiko Konosu-Fukaya; Yasuhiro Nakamura; Fumitoshi Satoh; Saulo J. A. Felizola; Takashi Maekawa; Yoshikiyo Ono; Ryo Morimoto; Kazue Ise; Ken-ichiro Takeda; Koshin Katsu; Fumiyoshi Fujishima; Atsuko Kasajima; Mika Watanabe; Yoichi Arai; Elise P. Gomez-Sanchez; Celso E. Gomez-Sanchez; Masao Doi; Hitoshi Okamura; Hironobu Sasano

  MOLECULAR AND CELLULAR ENDOCRINOLOGY, Jun. 2015, Peer-reviewed

  
• Hypertension Caused by Disruption of the Circadian System: Blood Pressure Regulation at Multiple Levels

  Hitoshi Okamura; Miho Yasuda; Jean-Michel Fustin; Masao Doi

  Circadian Medicine, 08 May 2015, Peer-reviewed

  
• Angiotensin II Triggers Expression of the Adrenal Gland Zona Glomerulosa-Specific 3 beta-Hydroxysteroid Dehydrogenase Isoenzyme through De Novo Protein Synthesis of the Orphan Nuclear Receptors NGFIB and NURR1

  Takumi Ota; Masao Doi; Fumiyoshi Yamazaki; Daisuke Yarimizu; Kazuki Okada; Iori Murai; Hida Hayashi; Sumihiro Kunisue; Yuuki Nakagawa; Hitoshi Okamura

  MOLECULAR AND CELLULAR BIOLOGY, Oct. 2014, Peer-reviewed

  
• Angiotensin II Triggers Expression of the Adrenal Gland Zona Glomerulosa-Specific 3 beta-Hydroxysteroid Dehydrogenase Isoenzyme through De Novo Protein Synthesis of the Orphan Nuclear Receptors NGFIB and NURR1

  Takumi Ota; Masao Doi; Fumiyoshi Yamazaki; Daisuke Yarimizu; Kazuki Okada; Iori Murai; Hida Hayashi; Sumihiro Kunisue; Yuuki Nakagawa; Hitoshi Okamura

  MOLECULAR AND CELLULAR BIOLOGY, Oct. 2014, Peer-reviewed

  
• Steroidogenic enzymes, their related transcription factors and nuclear receptors in human sebaceous glands under normal and pathological conditions

  Abdullah Azmahani; Yasuhiro Nakamura; Saulo J. A. Felizola; Yohei Ozawa; Kazue Ise; Takayoshi Inoue; Keely M. McNamara; Masao Doi; Hitoshi Okamura; Christos C. Zouboulis; Setsuya Aiba; Hironobu Sasano

  JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, Oct. 2014, Peer-reviewed

  
• Chronic hyperaldosteronism in Cryptochrome-null mice induces high-salt- and blood pressure-independent kidney damage in mice

  Dwi Aris Agung Nugrahaningsih; Noriaki Emoto; Nicolas Vignon-Zellweger; Eko Purnomo; Keiko Yagi; Kazuhiko Nakayama; Masao Doi; Hitoshi Okamura; Ken-ichi Hirata

  HYPERTENSION RESEARCH, Mar. 2014, Peer-reviewed

  
• Isoform-Specific Monoclonal Antibodies Against 3 beta-Hydroxysteroid Dehydrogenase/Isomerase Family Provide Markers for Subclassification of Human Primary Aldosteronism

  Masao Doi; Fumitoshi Satoh; Takashi Maekawa; Yasuhiro Nakamura; Jean-Michel Fustin; Motomi Tainaka; Yunhong Hotta; Yukari Takahashi; Ryo Morimoto; Kei Takase; Sadayoshi Ito; Hironobu Sasano; Hitoshi Okamura

  JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, Feb. 2014, Peer-reviewed

  
• Immunolocalization of murine type VI 3 beta-hydroxysteroid dehydrogenase in the adrenal gland, testis, skin, and placenta

  Koki Yamamura; Masao Doi; Hida Hayashi; Takumi Ota; Iori Murai; Yunhong Hotta; Rie Komatsu; Hitoshi Okamura

  MOLECULAR AND CELLULAR ENDOCRINOLOGY, Jan. 2014, Peer-reviewed

  
• [Intercellular communication-based robust circadian oscillation of the suprachiasmatic nucleus in the brain: mechanisms beyond intracellular clock machinery].

  Doi M

  Nihon rinsho. Japanese journal of clinical medicine, Dec. 2013, Peer-reviewed

  
• XRNA-methylation-dependent RNA processing controls the speed of the circadian clock

  Jean-Michel Fustin; Masao Doi; Yoshiaki Yamaguchi; Hayashi Hida; Shinichi Nishimura; Minoru Yoshida; Takayuki Isagawa; Masaki Suimye Morioka; Hideaki Kakeya; Ichiro Manabe; Hitoshi Okamura

  Cell, 07 Nov. 2013, Peer-reviewed

  
• Mice Genetically Deficient in Vasopressin V1a and V1b Receptors Are Resistant to Jet Lag

  Yoshiaki Yamaguchi; Toru Suzuki; Yasutaka Mizoro; Hiroshi Kori; Kazuki Okada; Yulin Chen; Jean-Michel Fustin; Fumiyoshi Yamazaki; Naoki Mizuguchi; Jing Zhang; Xin Dong; Gozoh Tsujimoto; Yasushi Okuno; Masao Doi; Hitoshi Okamura

  SCIENCE, Oct. 2013, Peer-reviewed

  
• Circadian Clock-Deficient Mice as a Tool for Exploring Disease Etiology

  Masao Doi

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Sep. 2012, Peer-reviewed

  
• [Circadian clocks and hypertension].

  Doi M; Okamura H

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica, May 2012, Peer-reviewed

  
• Involvement of urinary bladder Connexin43 and the circadian clock in coordination of diurnal micturition rhythm

  Hiromitsu Negoro; Akihiro Kanematsu; Masao Doi; Sylvia O. Suadicani; Masahiro Matsuo; Masaaki Imamura; Takeshi Okinami; Nobuyuki Nishikawa; Tomonori Oura; Shigeyuki Matsui; Kazuyuki Seo; Motomi Tainaka; Shoichi Urabe; Emi Kiyokage; Takeshi Todo; Hitoshi Okamura; Yasuhiko Tabata; Osamu Ogawa

  NATURE COMMUNICATIONS, May 2012, Peer-reviewed

  
• Rhythmic Nucleotide Synthesis in the Liver: Temporal Segregation of Metabolites

  Jean-Michel Fustin; Masao Doi; Hiroyuki Yamada; Rie Komatsu; Shigeki Shimba; Hitoshi Okamura

  CELL REPORTS, Apr. 2012, Peer-reviewed

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• [Circadian rhythm abnormality and hypertension].

  Okamura H; Doi M

  Nihon rinsho. Japanese journal of clinical medicine, Feb. 2012, Peer-reviewed

  
• Circadian clock signals in the adrenal cortex

  Takumi Ota; Jean-Michel Fustin; Hiroyuki Yamada; Masao Doi; Hitoshi Okamura

  MOLECULAR AND CELLULAR ENDOCRINOLOGY, Feb. 2012, Peer-reviewed

  
• Accurate Determination of S-Phase Fraction in Proliferative Cells by Dual Fluorescence and Peroxidase Immunohistochemistry with 5-Bromo-2 '-Deoxyuridine (BrdU) and Ki67 Antibodies

  Rina Tanaka; Motomi Tainaka; Takumi Ota; Naoki Mizuguchi; Hiroyuki Kato; Shoichi Urabe; Yulin Chen; Jean-Michel Fustin; Yoshiaki Yamaguchi; Masao Doi; Shinshichi Hamada; Hitoshi Okamura

  JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, Aug. 2011, Peer-reviewed

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• Transportin 1 in the Mouse Brain: Appearance in Regions of Neurogenesis, Cerebrospinal Fluid Production/Sensing, and Circadian Clock

  Miho Sato; Yasutaka Mizoro; Yuta Atobe; Yoshito Fujimoto; Yoshiaki Yamaguchi; Jean-Michel Fustin; Masao Doi; Hitoshi Okamura

  JOURNAL OF COMPARATIVE NEUROLOGY, Jun. 2011, Peer-reviewed

  
• Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus

  Masao Doi; Atsushi Ishida; Akiko Miyake; Miho Sato; Rie Komatsu; Fumiyoshi Yamazaki; Ikuo Kimura; Soken Tsuchiya; Hiroshi Kori; Kazuyuki Seo; Yoshiaki Yamaguchi; Masahiro Matsuo; Jean-Michel Fustin; Rina Tanaka; Yasuko Santo; Hiroyuki Yamada; Yukari Takahashi; Michihiro Araki; Kazuki Nakao; Shinichi Aizawa; Masaki Kobayashi; Karl Obrietan; Gozoh Tsujimoto; Hitoshi Okamura

  NATURE COMMUNICATIONS, May 2011, Peer-reviewed

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• Hypertension Due to Loss of Clock: Novel Insight From the Molecular Analysis of Cry1/Cry2-Deleted Mice

  Hitoshi Okamura; Masao Doi; Yoshiaki Yamaguchi; Jean-Michel Fustin

  CURRENT HYPERTENSION REPORTS, Apr. 2011, Peer-reviewed

  
• Control of Circadian Phase by an Artificial Zinc Finger Transcription Regulator

  Miki Imanishi; Atsushi Nakamura; Masao Doi; Shiroh Futaki; Hitoshi Okamura

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, Peer-reviewed

  
• Mammalian circadian clock system: Molecular mechanisms for pharmaceutical and medical sciences

  Hitoshi Okamura; Masao Doi; Jean-Michel Fustin; Yoshiaki Yamaguchi; Masahiro Matsuo

  ADVANCED DRUG DELIVERY REVIEWS, Jul. 2010, Peer-reviewed

  
• Activation of AMPA Receptors in the Suprachiasmatic Nucleus Phase-Shifts the Mouse Circadian Clock In Vivo and In Vitro

  Yasutaka Mizoro; Yoshiaki Yamaguchi; Rena Kitazawa; Hiroyuki Yamada; Masahiro Matsuo; Jean-Michel Fustin; Masao Doi; Hitoshi Okamura

  PLOS ONE, Jun. 2010, Peer-reviewed

  
• Mammalian Clock Gene Cryptochrome Regulates Arthritis via Proinflammatory Cytokine TNF-alpha

  Akira Hashiramoto; Takashi Yamane; Ken Tsumiyama; Kohsuke Yoshida; Koichiro Komai; Hiroyuki Yamada; Fumiyoshi Yamazaki; Masao Doi; Hitoshi Okamura; Shunichi Shiozawa

  JOURNAL OF IMMUNOLOGY, Feb. 2010, Peer-reviewed

  
• Circadian clocks in adrenal aldosterone-secreting cells

  Takumi Ota; Masao Doi; Hitoshi Okamura

  NEUROSCIENCE RESEARCH, 2010, Peer-reviewed

  
• Clock genes and diseases

  Masao Doi; Hitoshi Okamura

  NEUROSCIENCE RESEARCH, 2010, Peer-reviewed

  
• Salt-sensitive hypertension in circadian clock-deficient Cry-null mice involves dysregulated adrenal Hsd3b6

  Masao Doi; Yukari Takahashi; Rie Komatsu; Fumiyoshi Yamazaki; Hiroyuki Yamada; Shogo Haraguchi; Noriaki Emoto; Yasushi Okuno; Gozoh Tsujimoto; Akihiro Kanematsu; Osamu Ogawa; Takeshi Todo; Kazuyoshi Tsutsui; Gijsbertus T. J. van der Horst; Hitoshi Okamura

  NATURE MEDICINE, Jan. 2010, Peer-reviewed

  
• Circadian characteristics of mice depleted with GPR7

  Naohiro Uchio; Masao Doi; Masahiro Matsuo; Fumiyoshi Yamazaki; Yasutaka Mizoro; Mari Hondo; Takeshi Sakurai; Hitoshi Okamura

  BIOMEDICAL RESEARCH-TOKYO, Dec. 2009, Peer-reviewed

  
• Molecular Clocks in Mouse Skin

  Miki Tanioka; Hiroyuki Yamada; Masao Doi; Hideki Bando; Yoshiaki Yamaguchi; Chikako Nishigori; Hitoshi Okamura

  JOURNAL OF INVESTIGATIVE DERMATOLOGY, May 2009, Peer-reviewed

  
• The dorsomedial hypothalamic nucleus is not necessary for food-anticipatory circadian rhythms of behavior, temperature or clock gene expression in mice

  Takahiro Moriya; Reiko Aida; Takashi Kudo; Masashi Akiyama; Masao Doi; Naomi Hayasaka; Norimichi Nakahata; Ralph Mistlberger; Hitoshi Okamura; Shigenobu Shibata

  EUROPEAN JOURNAL OF NEUROSCIENCE, Apr. 2009, Peer-reviewed

  
• Circadian expression of the Na+/H+ exchanger NHE3 in the mouse renal medulla

  Hiromi Nishinaga; Rie Komatsu; Masao Doi; Jean-Michel Fustin; Hiroyuki Yamada; Ryusuke Okura; Yoshiaki Yamaguchi; Masahiro Matsuo; Noriaki Emoto; Hitoshi Okamura

  BIOMEDICAL RESEARCH-TOKYO, Apr. 2009, Peer-reviewed

  
• On the Communication Pathways between the Central Pacemaker and Peripheral Oscillators

  Nicolas Cermakian; Matthew P. Pando; Masao Doi; Luca Cardone; Irene Yujnovsky; David Morse; Paolo Sassone-Corsi

  Molecular Clocks and Light Signalling, Oct. 2008, Peer-reviewed

  
• Circadian expression of 86-and 84-kDa heat shock proteins in the mouse suprachiasmatic nucleus

  Tsuyoshi Fukuyama; Masao Doi; Masahiro Matsuo; Hiromi Nishinaga; Shigeru Miyake; Hitoshi Okamura

  BIOMEDICAL RESEARCH-TOKYO, Apr. 2008, Peer-reviewed

  
• Light-inducible and clock-controlled expression of MAP kinase phosphatase 1 in mouse central pacemaker neurons

  Masao Doi; Sehyung Cho; Irene Yujnovsky; Jun Hirayama; Nicloas Cermakian; Andrew C. B. Cato; Paolo Sassone-Corsi

  JOURNAL OF BIOLOGICAL RHYTHMS, Apr. 2007, Peer-reviewed

  
• Impaired light masking in dopamine D2 receptor-null mice

  M Doi; Yujnovsky, I; J Hirayama; M Malerba; E Tirotta; P Sassone-Corsi; E Borrelli

  NATURE NEUROSCIENCE, Jun. 2006, Peer-reviewed

  
• Circadian regulator CLOCK is a histone acetyltransferase

  M Doi; J Hirayama; P Sassone-Corsi

  CELL, May 2006, Peer-reviewed

  
• Signaling mediated by the dopamine D2 receptor potentiates circadian regulation by CLOCK : BMAL1

  Yujnovsky, I; J Hirayama; M Doi; E Borrelli; P Sassone-Corsi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Apr. 2006, Peer-reviewed

  
• Lcg is a light-inducible and clock-controlled gene expressed in the chicken pineal gland

  M Hatori; T Okano; Y Nakajima; M Doi; Y Fukada

  JOURNAL OF NEUROCHEMISTRY, Mar. 2006, Peer-reviewed

  
• Common pathways in circadian and cell cycle clocks: Light-dependent activation of Fos/AP-1 in zebrafish controls CRY-1a and WEE-1

  J Hirayama; L Cardone; M Doi; P Sassone-Corsi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jul. 2005, Peer-reviewed

  
• Protein phosphorylation-dependent regulation of circadian timekeeping

  M Doi; T Okano

  SEIKAGAKU, Feb. 2005, Peer-reviewed

  
• Transplantation of mouse embryo fibroblasts: An approach to study the physiological pathways linking the suprachiasmatic nucleus and peripheral clocks

  SY Cho; Yujnovsky, I; M Doi; P Sassone-Corsi

  CIRCADIAN RHYTHMS, 2005, Peer-reviewed

  
• Transplantation of mouse embryo fibroblasts: An approach to study the physiological pathways linking the suprachiasmatic nucleus and peripheral clocks

  SY Cho; Yujnovsky, I; M Doi; P Sassone-Corsi

  CIRCADIAN RHYTHMS, 2005, Peer-reviewed

  
• Crystal structure and interactions of the PAS repeat region of the Drosophila clock protein PERIOD

  O Yildiz; M Doi; Yujnovsky, I; L Cardone; A Berndt; S Hennig; S Schulze; C Urbanke; P Sassone-Corsi; E Wolf

  MOLECULAR CELL, Jan. 2005, Peer-reviewed

  
• Negative control of circadian clock regulator E4BP4 by casein kinase I epsilon-mediated phosphorylation

  M Doi; T Okano; Yujnovsky, I; P Sassone-Corsi; Y Fukada

  CURRENT BIOLOGY, Jun. 2004, Peer-reviewed

  
• On the communication pathways between the central pacemaker and peripheral oscillators

  N. Cermakian; M.P. Pando; M. Doi; L. Cardone; I. Yujnovsky; D. Morse; P. Sassone-Corsi

  Novartis Foundation Symposium, 2003, Peer-reviewed

  
• Light-dependent changes in the chick pineal temperature and the expression of cHsp90 alpha gene: A potential contribution of in vivo temperature change to the photic-entrainment of the chick pineal circadian clock

  M Doi; Y Nakajima; T Okano; Y Fukada

  ZOOLOGICAL SCIENCE, Jun. 2002, Peer-reviewed

  
• Light-induced phase-delay of the chicken pineal circadian clock is associated with the induction of cE4bp4, a potential transcriptional repressor of cPer2 gene

  Masao Doi; Yoshito Nakajima; Toshiyuki Okano; Yoshitaka Fukada

  Proceedings of the National Academy of Sciences of the United States of America, 2001, Peer-reviewed

  

Misc.

• 体温のサーカディアンリズムに全身の時計を調和させるmRNAシスエレメントの発見

  三宅崇仁; 土居雅夫

  生体の科学, 2024

  
• 神経疾患におけるオリゴデンドロサイト

  瀬田孟仁; 土居雅夫; 村松里衣子

  月間「細胞」, 2024

  
• 逆-時間生理学

  土居雅夫

  日本時間生物学会誌, 2022

  
• 睡眠覚醒の日内リズムを司る体内時計と体温の相互支配的な関係

  邵欣彦; 三宅崇仁; 土居雅夫

  老年精神医学雑誌, 2024

  
• 最小単位uORF翻訳を介した体内時計調律：ゆるやかな体温変動にしなやかに調和する時計の仕組み

  三宅崇仁; 土居雅夫

  生化学, 2023

  
• 蕭穗文、土居雅夫

  Monthly Book OCULISTA, 2023

  
• 体内時計とドライアイ

  濵田悠貴; 土居雅夫

  Precision Medicine, 2023

  
• ニコチンアミドモノヌクレオチドを用いた加齢性ドライアイ治療へ

  蕭穗文; 土居雅夫

  MEDCHEM NEWS, 2023

  
• イントラクライン機構の再活性化による加齢性ドライアイ軽減―NAD+とサーカディアンリズムが鍵―

  上原日佳梨; 土居雅夫

  Geriatric Medicine（老年医学）, 2023

  
• NAD+によるイントラクラインを介した加齢性ドライアイ軽減法

  土居雅夫; 佐々木玲奈; 濵田悠貴; 鑓水大介

  実験医学, 2022

  
• 体内時計の分子機構と疾病治療への展望 (特集 時間薬理学--最適な投与方法を求めて)

  山崎 文義; 土居 雅夫; 岡村 均

  医薬ジャ-ナル, Jun. 2009

  
• ANALYSIS OF PUTATIVE CLOCK-RELATED GENES INDUCED BY LIGHT IN A PHASE-DEPENDENT MANNER(Physiology&Biochemistry,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan) :

  Hatori Megumi; Okano Toshiyuki; Nakajima Yoshito; Doi Masao; Fukada Yoshitaka

  Zoological science, 2003

  
• 老化と体内時計：加齢による脳内中枢時計の機能低下を中心に

  濵田悠貴; 山口賀章; 土居 雅夫

  Geriatric Medicine（老年医学）, Jul. 2021, Invited

  
• 時間生物学と医療の融合－現状と将来－

  土居 雅夫

  メディカル・サイエンス・ダイジェスト, Jun. 2021, Invited

  
• 行動・基礎体温の日内リズムの維持に必要な時計遺伝子の転写調節シスエレメント

  土居 雅夫

  新学術「温度生物学」ニュースレター, Jul. 2020, Invited

  
• 変温動物の日内体温制御

  三宅 崇仁; 土居 雅夫

  新学術領域研究 温度生物学ハンドブック, May 2020, Peer-reviewed, Invited

  
• 時計遺伝子の転写のシス制御エレメントに点変異を入れると体内時計はどうなるのか

  Nguyen Pham; Khanh Tien; 土居 雅夫

  生化学, 2020, Peer-reviewed, Invited

  
• 体内時計の中枢を調節するG蛋白質共役型受容体

  嶋谷 寛之; 土居 雅夫

  膜タンパク質工学ハンドブック(エヌ・ティー・エス出版), 2020, Invited

  
• 昼寝の時刻の体温を制御する脳内中枢時計の分子機構

  前川 洋太; 土居 雅夫

  内分泌・糖尿病・代謝内科, 2019, Invited

  
• 体内時計の中枢を調節するG蛋白質共役型受容体シグナル

  中川 峻平; 土居 雅夫

  医学のあゆみ, Nov. 2018, Invited

  
• 「昼寝」の体温リズムを調整する遺伝子を発見

  土居 雅夫

  化学, Mar. 2018, Invited

  
• Gz-linked orphan GPCR regulating the center of the circadian clock

  Sumihiro Kunisue; Masao Doi

  Seikagaku, 2017, Invited

  
• 活性化した筋衛星細胞におけるMyoD依存的なGm7325遺伝子の発現

  武井大祐; 西美幸; 深田宗一朗; 土居雅夫; 岡村均; 上住聡芳; 吉田守克; 宮里幹也; 市村敦彦; 市村敦彦; 竹島浩

  日本筋学会学術集会プログラム・抄録集, Jul. 2017

  
• 【脳と時計-睡眠リズム障害を中心として-】 体内時計の中枢を制御するオーファンG蛋白質共役受容体

  土居 雅夫; 岡村 均

  BIO Clinica, Aug. 2016, Invited

  
• 体内時計の中枢を制御するオーファンGPCRの同定

  土居 雅夫; 岡村 均

  医学のあゆみ, May 2016, Invited

  
• 生活習慣病と体内時計

  土居 雅夫

  日本内科学会雑誌, Apr. 2016

  
• 視交叉上核ニューロンの概日振動を調節するGz共役型オーファン受容体の同定

  土居 雅夫

  ブレインサイエンス・レビュー, Feb. 2016

  
• 【GPCR研究の最前線2016】 GPCR機能の新展開【精神・神経・睡眠・摂食】 生体リズムを調節するGPCR

  土居 雅夫; 岡村 均

  医学のあゆみ, Jan. 2016

  
• 【概日リズムと疾患】 概日リズム異常による高血圧

  鑓水 大介; 土居 雅夫; 岡村 均

  Medical Science Digest, Oct. 2015

  
• 新しいアルドステロン症の病理診断

  土居 雅夫; 岡村 均

  腎臓内科・泌尿器科, Oct. 2015

  
• Aldosterone産生腺腫のCYP11B1、CYP11B2、HSD3B1、HSD3B2発現における免疫組織化学的検討と遺伝子解析

  小野 美澄; 深谷 佐智子; 中村 保宏; 森本 玲; 岩倉 芳倫; 祢津 昌広; 工藤 正孝; 尾股 慧; 手塚 雄太; 五十嵐 康宏; 北脇 優子; 山崎 有人; 土居 雅夫; 岡村 均; 伊藤 貞嘉; 笹野 公伸; 佐藤 文俊

  日本内分泌学会雑誌, Sep. 2015

  
• 【中枢神経系によるエネルギー代謝調節機構】 中枢時計とエネルギー代謝制御

  薛 元瑞; 土居 雅夫; 岡村 均

  内分泌・糖尿病・代謝内科, Jul. 2015

  
• 原発性アルドステロン症の新規病理鑑別診断とステロイド合成の病態生理

  佐藤 文俊; 小野 美澄; 森本 玲; 岩倉 芳倫; 尾股 慧; 工藤 正孝; 清治 和将; 高瀬 圭; 中村 保宏; 土居 雅夫; 岡村 均; 笹野 公伸; 伊藤 貞嘉

  日本高血圧学会総会プログラム・抄録集, Oct. 2014

  
• Novel Pathological Diagnosis Between Aldosterone Producing Adenoma And Idiopathic Hyperaldosteronism

  Fumitoshi Satoh; Yoshikiyo Ono; Ryo Morimoto; Masataka Kudo; Yoshitsugu Iwakura; Kei Omata; Kazumasa Seiji; Kei Takase; Yasuhiro Nakamura; Masao Doi; Hitoshi Okamura; Celso Gomez-Sanchez; Hironobu Sasano; Sadayoshi Ito

  HYPERTENSION, Sep. 2014

  
• 【医学・医療のいまがわかるキーワード2014】 生化学・分子生物学 時計遺伝子

  土居 雅夫; 岡村 均

  医学のあゆみ, May 2014

  
• 生体リズムと生活習慣病 生体リズムと高血圧

  岡村 均; 土居 雅夫

  循環plus, May 2014

  
• アルドステロン研究Update 原発性アルドステロン症Update 臨床診断と病理診断の進歩

  佐藤 文俊; 森本 玲; 工藤 正孝; 岩倉 芳倫; 小野 美澄; 尾股 慧; 高瀬 圭; 清治 和将; 土居 雅夫; 岡村 均; 中村 保宏; 笹野 公伸; 伊藤 貞嘉

  日本内分泌学会雑誌, Apr. 2014

  
• 【概日リズムと疾患-病態・診断・治療の最新知見-】 時計遺伝子と生体リズム調節分子

  土居 雅夫

  日本臨床, Dec. 2013

  
• 【原発性アルドステロン症Update 2013】 原発性アルドステロン症のトランスレーショナルリサーチ 時計遺伝子と高血圧の出会い

  岡村 均; 土居 雅夫

  医学のあゆみ, Nov. 2013

  
• 【原発性アルドステロン症:Up-date】 生体リズム異常による高アルドステロン血症と血圧の多層的制御機構

  岡村 均; 土居 雅夫

  血圧, Aug. 2013

  
• 【原発性アルドステロン症-診断と治療の新展開】 特発性アルドステロン症と時計遺伝子

  土居 雅夫; 岡村 均

  カレントテラピー, Jul. 2013

  
• 【パーフェクト24時間血圧コントロールを目指す 睡眠・サーカディアン高血圧治療】 生体のサーカディアンリズム 時計遺伝子と高血圧の発生機序

  土居 雅夫; 岡村 均

  Circulation, Apr. 2013

  
• 人工DNA結合蛋白質による細胞分子時計の操作

  今西未来; 中村篤史; 山本和俊; 土居雅夫; 岡村均; 二木史朗

  「細胞を創る」研究会5.0 ,横浜（東京工業大学）, 21 Nov. 2012, Peer-reviewed

  
• The bladder has got rhythm: Involvement of bladder circadian clock and Connexin43 in the coordination of diurnal micturition rhythm

  Hiromitsu Negoro; Akihiro Kanematsu; Masao Doi; Sylvia O. Suadicani; Masaaki Imamura; Takeshi Okinami; Nobuyuki Nishikawa; Hitoshi Okamura; Yasuhiko Tabata; Osamu Ogawa

  American Academy of Pediatrics 2012 National Conference and Exhibition, Oct. 2012

  
• Period1プロモーターを標的とした人工転写因子による細胞時計のリセット

  今西未来; 中村篤史; 土居雅夫; 二木史朗; 岡村均

  第19回日本時間生物学会学術大会 ,札幌（北海道大学）, 15 Sep. 2012, Peer-reviewed

  
• 【高血圧のすべて2012-研究と診療の最前線】 高血圧の成因に関する新知見 生体リズム異常と高血圧

  岡村 均; 土居 雅夫

  医学のあゆみ, Jun. 2012

  
• 生体リズム異常と高血圧

  土居 雅夫; 岡村 均

  現代医学, Jun. 2012

  
• Resetting of the cellular circadian clock by an artificial zinc-finger transcription factor

  Imanishi, M; Nakamura, A; Doi, M; Okamura, H; Futaki, S

  金属の関与する生体関連反応シンポジウム(SRM2012) ,金沢（金沢大学）, 31 May 2012, Peer-reviewed

  
• キーワード解説 時計遺伝子と高血圧

  土居 雅夫; 岡村 均

  日本薬理学雑誌, May 2012

  
• ヒト副腎組織における3β-HSD subtypeの発現および特異性

  前川 尚志; 中村 保宏; 土居 雅夫; 佐藤 文俊; 伊勢 和恵; Felizola Saulo; 岡村 均; 笹野 公伸

  日本病理学会会誌, Mar. 2012

  
• 生体リズムと高血圧

  岡村 均; 土居 雅夫

  日本臨床, Feb. 2012

  
• これからもっと増える生体リズム調節分子 細胞時計からシステム時計の解析へ

  土居 雅夫; 岡村 均

  細胞工学, Feb. 2012

  
• 細胞内Gタンパク質シグナルの仕分けが生体リズムのタイミングを決める 目覚まし遺伝子Rgs16の発見

  土居 雅夫; 岡村 均

  化学と生物, Jan. 2012

  
• 【体内時計と疾病】 高血圧と生体リズム異常 あらたな高血圧治療薬の開発に向けて

  土居 雅夫

  医学のあゆみ, Nov. 2011

  
• 疾患の病因と病態 生体リズム異常とアルドステロン産生過剰を伴う高血圧

  岡村 均; 土居 雅夫

  Annual Review循環器, Jan. 2011

  
• 内分泌 基礎分野での進歩 生体リズムと高血圧

  岡村 均; 土居 雅夫

  Annual Review糖尿病・代謝・内分泌, Jan. 2011

  
• 【体内時計と身近な病気】 時計遺伝子と高血圧

  土居 雅夫; 岡村 均

  脳21, Oct. 2010

  
• 【代謝・自律神経ネットワークと血圧調節】 血圧調節にかかわる内分泌・代謝・自律神経ネットワーク

  岡村 均; 土居 雅夫

  血圧, Oct. 2010

  
• ゲノムレベルでの時計遺伝子プロモーター解析を目指した亜鉛フィンガー型人工転写因子の創製とその機能

  中村篤史; 中村篤史; 今西未来; 土居雅夫; 岡村均; 二木史朗

  日本ケミカルバイオロジー学会第5年会 ,横浜（慶応義塾大学日吉キャンパス）, 19 May 2010, Peer-reviewed

  
• 生体リズム異常に伴う高血圧発症メカニズム

  土居雅夫; 岡村均

  実験医学, 2010

  
• 【化粧品科学の新たな視点を探る】 皮膚における生体リズムの分子機構

  山田 裕之; 土居 雅夫; 岡村 均

  FRAGRANCE JOURNAL, Jan. 2010

  
• 【時間と病気 生体時計から時間医学へ】 分子からみた生体リズムの時間機構

  土居 雅夫; 岡村 均

  Medical Bio, Nov. 2009

  
• 時計遺伝子プロモーター解析へ向けた亜鉛フィンガー型人工転写因子の創製

  中村篤史; 中村篤史; 今西未来; 土居雅夫; 岡村均; 二木史朗

  第6回アジア睡眠学会 日本睡眠学会第34回定期学術集会 第16回日本時間生物学会学術大会. 2009 合同大会 ,大阪, 27 Oct. 2009, Peer-reviewed

  
• 【時間薬理学 最適な投与方法を求めて】 体内時計の分子機構と疾病治療への展望

  山崎 文義; 土居 雅夫; 岡村 均

  医薬ジャーナル, Jun. 2009

  
• The dorsomedial hypothalamus is not necessary for food-associated rhythms of behavior, temperature or clock gene expression in mice

  Takahiro Moriya; Reiko Aida; Takashi Kudo; Masashi Akiyama; Masao Doi; Naomi Hayasaka; Ralph Mistlberger; Hitoshi Okamura; Shigenobu Shibata; Norimichi Nakahata

  NEUROSCIENCE RESEARCH, 2009

  
• 【中枢時計と末梢時計 時計遺伝子研究の最前線】 概日時計システムの総論 生物時計システムにおけるネガティブフィードバック理論の確立と展開

  岡村 均; 土居 雅夫

  Clinical Neuroscience, Oct. 2007

  
• 時計タンパク質CLOCKのヒストンアセチル化酵素としての働き

  土居雅夫; Paolo Sassone-Corsi

  実験医学, 2006

  
• 時計遺伝子の転写機構

  土居雅夫; Paolo Sassone-Corsi

  医学のあゆみ, 2006

  
• A clock-related gene Lcg expressed in the chicken pineal gland

  Megumi Hatori; Toshiyuki Okano; Yoshito Nakajima; Masao Doi; Yoshitaka Fukada

  ZOOLOGICAL SCIENCE, Dec. 2005

  
• 体内時計の時間調節を担うタンパク質リン酸化反応

  土居 雅夫; 岡野 俊行

  生化学, Feb. 2005

  
• 脳内光受容と体内時計の時刻調節ー動物が体内時計をリセットする仕組みー

  深田吉孝; 土居雅夫

  現代化学, Jan. 2002

  
• 概日時計の光位相制御に関わる転写因子E4BP4の同定

  土居 雅夫; 中島 芳人; 岡野 俊行; 深田 吉孝

  神経化学, Sep. 2001

  
• ニワトリ松果体における概日時計の光位相シフトに関わる転写抑制因子E4BP4

  岡野 俊行; 土居 雅夫; 中島 芳人; 深田 吉孝

  生化学, Aug. 2001

  
• 時計遺伝子cPer2の転写を光依存的に抑制する転写因子E4BP4の同定

  2001

  
• Chicken pineal E4bp4 : Transcriptional repressor of cPer2 gene

  Keystone Symposia on Molecular Clocks, 2001

  
• ニワトリ松果体の概日時計システムにおける転写因子E4BP4の役割

  米アカデミー紀要, 2001

  
• 概日時計の光位相シフトに関与する遺伝子の探索

  第73回日本生化学会大会, 2000

  
• Screen for genes involving in light-entrainment of circadian clock

  2000

  
• ニワトリ松果体における時計関連遺伝子の探索

  第70回日本動物学会大会, 1999

  
• Screen for clock-relate genes in chicken pineal gland

  1999

  
• ニワトリ松果体におけるHSP90遺伝子転写量の日周変動

  第5回日本光生物学協会, 1998

  
• Circadian expression of hsp90 gene in chicken pineal gland

  1998

  

Presentations

• 化学遺伝学的GPCRツールの小型化と脳神経回路のマルチモード制御への応用

  田中香帆; 三宅崇仁; 土居雅夫

  第145回日本薬学会年会, 28 Mar. 2025

  
• 体内時計中枢SCNのex vivo培養における概日性キナーゼ活性変動の観察

  田中陽一; 土居雅夫

  第145回日本薬学会年会, 27 Mar. 2025

  
• Reexamination of the mechanism of oscillation and phase control of clock genes based on parametric control in translation

  Masao Doi

  APPW2025(第130回日本解剖学会/第102回日本生理学会/第98回日本薬理学会合同大会), 18 Mar. 2025

  
• Identification of Meibomian Gland Testosterone Metabolites Produced by Tissue-Intrinsic Intracrine Deactivation Activity

  Khanh Tien Nguyen Pham; Takahito Miyake; Masao Doi

  The 12th SKO Symposium, 18 Nov. 2024

  
• 翻訳制御を介した細胞時計のパラメトリックな温度エントレイメント

  土居雅夫

  第31回日本時間生物学会学術大会, 17 Nov. 2024

  
• 日常診療で汎用される降圧薬カンデサルタンによる副腎球状層細胞の分子時計のリセット

  大谷知寛; 三宅崇仁; 土居雅夫

  第31回日本時間生物学会学術大会, 16 Nov. 2024

  
• SABER-FISH Identifies V1a Expression in VIPergic Neurons in the SCN

  Huihua Zhou; Morio Azuma; Taka-aki Koshimizu; Emi Hasegawa; Masao Doi

  第31回日本時間生物学会学術大会, 16 Nov. 2024

  
• 翻訳のパラメトリク制御に基づく時計遺伝子の発振・位相調節機構の再考

  土居雅夫

  第97回日本生化学会大会, 06 Nov. 2024

  
• マイボーム腺組織内因性イントラクライン活性により産出されるテストステロン代謝物の同定

  Khanh Tien Nguyen Pham; 三宅崇仁; 土居雅夫

  第97回日本生化学会大会, 06 Nov. 2024

  
• 時間生物学に立脚した加齢性疾患への治療アプローチ

  土居雅夫

  第77回日本自律神経学会総会, 25 Oct. 2024

  
• First in Class NMN薬に向けてー老化・体内時計薬の考え方ー

  土居雅夫

  名古屋大学環境医学セミナー, 25 Sep. 2024

  
• Reexamination of the mechanism of oscillation and phase control of clock genes based on parametric translationanl regulation

  Masao Doi

  Asia Forum on Chronobiology 2024, 11 Aug. 2024, Invited

  
• Circadian intracrine activity governs age-associated meibomian gland dysfunction and evaporative dry eye disease.

  Sui-Wen Hsiao; Masao Doi

  Sapporo Symposium on BIOLOGICAL RHYTHM 2024, 10 Aug. 2024

  
• Candesartan, an antihypertensive drug used in daily clinical practice, resets the molecular clock in the adrenal cortex zona glomerulosa cells

  Tomohiro Otani; Takahito Miyake; Masao Doi

  Sapporo Symposium on BIOLOGICAL RHYTHM 2024, 10 Aug. 2024

  
• The size-reduced DREADD derivatives for AAV-assisted multimodal chemogenetic control of neuronal activity and behavior

  土居雅夫

  第18回GPCR研究会, 25 May 2024

  
• 発光半減期アッセイによるGPCRのリガンドに依存した分解促進の検出

  森下和奏; 土居雅夫

  第18回GPCR研究会, 25 May 2024

  
• 化学遺伝学的GPCRツールの小型化と神経回路機能制御への応用

  田中香帆; 三宅崇仁; 土居雅夫

  第18回GPCR研究会, 25 May 2024

  
• Local testosterone synthesis by intracrine mechanism in the Meibomian gland

  Tomo Suzuki; Lena Sasaki; Shigeru Kinoshita; Masao Doi

  ARVO2024, 09 May 2024

  
• The role of the minimal upstream open reading frame of Per2

  Masao Doi

  China-Japan Chronobiology Summit Forum, 11 Dec. 2023, Invited

  
• Intracrine activity in the meibomian gland: A nexus between circadian clock and MGD

  Masao Doi

  The 29th Annual Meeting of Kyoto Cornea Club, 17 Nov. 2023, Invited

  
• Circadian intracrine activity governs age-associated meibomian gland dysfunction and evaporative dry eye disease

  Masao Doi

  Sapporo Symposium on BIOLOGICAL RHYTHM 2022, 14 Aug. 2022, Invited

  
• Circadian steroidogenesis and ageing-associated disease

  Masao Doi

  XVII EUROPEAN BIOLOGICAL RHYTHMS SOCIETY CONGRESS, 26 Jul. 2022

  
• Circadian clock: disease etiology and drug target exploration

  Masao Doi

  The 5th Asian Forum on Chronobiology, 17 Jul. 2021

  
• Time as medicine and disease etiology

  Masao Doi

  The CFBT Summer Showcase, Manchester, 29 Jun. 2021, Invited

  
• Research for drug discovery aimed at circadian rhythm regulation by time-restricted gating of G-protein signaling

  Masao Doi

  第85回日本循環器学会学術集会, 27 Mar. 2021, Invited

  
• 時計遺伝子のシス制御エレメントが個体の活動や生理リズムの維持に与える影響の範囲・限界

  土居雅夫

  第43回日本分子生物学会年会, 04 Dec. 2020

  
• 加齢性睡眠障害/早朝覚醒の鍵を握る生体リズム機構

  土居雅夫

  AMED老化メカニズムの解明・制御プロジェクト 一般社団法人Link-J共催 老化研究産学連携シンポジウム, 09 Nov. 2020

  
• 脳内サーカディアンリズム中枢を制御する時間選択的Gタンパク質シグナル伝達経路GPR176-Gz-RGS16の役割

  土居雅夫

  第９３回日本生化学会大会, 15 Sep. 2020

  
• 昼寝の体温・代謝リズムを制御する脳内サーカディアンリズム中枢の分子機構

  土居雅夫

  第34回日本糖尿病・肥満動物学会, 31 Jan. 2020, Invited

  
• Per2遺伝子プロモーターシス調節配列E’-boxを欠損したマウス個体の脆弱な概日振動

  土居雅夫

  第26回日本時間生物学会年会, 13 Oct. 2019

  
• 温度生物学と時間生物学の交差点

  土居雅夫

  新学術領域「温度生物学」若手の会トピカル講演, 08 Sep. 2019

  
• Non-coding cis-regulatory element E’-box of Period2 is essential for daily maintenance of organismal behavior and physiology

  Masao Doi

  第3回日本循環器学会基礎研究フォーラム, 07 Sep. 2019, Invited

  
• 体内時計の転写・翻訳フィードバックループにおける翻訳制御の役割

  土居雅夫

  大阪大学蛋白質研究所セミナー, 09 Aug. 2019

  
• The circadian clock regulator Gpr176 undergoes N-glycosylation and couples to Gz

  土居雅夫

  第15回GPCR研究会, 25 May 2019

  
• Time-restricted G-protein signaling through Gpr176/Gz/Rgs16 sets the pace of the central clock.

  Masao Doi

  V World Congress for Chronobiology, 25 Apr. 2019, Invited

  
• オーファンG蛋白質共役受容体シグナルの生化学を基軸とした生体リズム中枢調整薬の研究開発

  土居雅夫

  生化学若い研究者の会 冬のセミナー, 26 Jan. 2019, Invited

  
• 昼寝の体温を制御する脳内中枢時計の分子機構

  土居雅夫

  第３回バイオサーモロジーワークショップ ー1℃の違いを知るー, 25 Dec. 2018, Invited

  
• Circadian regulation of G-protein signaling defines morning person. Are you a lark or an owl?

  Masao Doi

  Special Lecture, Taipei Medical University, 19 Oct. 2018, Invited

  
• 昼寝の体温を制御するGPCR

  土居雅夫

  生理学研究所研究会 運動器/代謝系連関による生体機能制御とその変容の仕組み, 23 Sep. 2018, Invited

  
• 体内時計の中枢を制御するG蛋白質共役受容体シグナル

  土居雅夫

  第22回睡眠科学研究講座, 10 Jul. 2018, Invited

  
• 体温のサーカディアンリズムを制御する脳内中枢時計の分子機構

  土居雅夫

  第65回日本実験動物学会総会, 16 May 2018, Invited

  
• 脳内中枢時計によるG蛋白質共役受容体を介した体温の概日性制御機構

  土居雅夫

  次世代脳プロジェクト冬のシンポジウム, 20 Dec. 2017, Invited

  
• A role of G-protein-coupled receptor in daily coordination of mouse body temperature

  Masao Doi

  第24回日本時間生物学会年会, 29 Oct. 2017

  
• 生体リズム中枢における創薬標的分子探索

  土居雅夫

  第39回日本生物学的精神医学会・第47回日本神経精神薬理学会, 28 Sep. 2017

  
• Sleep Brain: Why do we need sleep?

  Masao Doi

  The Japanese-American-German Frontiers of Science Symposium 2017,, 23 Sep. 2017, Invited

  
• G-protein coupled receptors in the SCN: Timed Gi/Gz signaling sets the pace of the central clock.

  Masao Doi

  European Biological Rhythms Society Congress, 02 Aug. 2017

  
• 生物時計を標的にした創薬戦略

  土居雅夫

  日本睡眠学会第42回定期学術集会, 29 Jun. 2017, Invited

  
• 体内時計の中枢を調節するG蛋白質共役型受容体シグナル機構

  土居雅夫

  第90回日本内分泌学会学術総会, 21 Apr. 2017, Invited

  

Books and Other Publications

• 原発性アルドステロン症診療マニュアル 改訂第４版

  岡村 均; 土居雅夫, Contributor, 原発性アルドステロン症の成因（生体リズム異常）

  診断と治療社, 2024

  
• くすりをつくる研究者の仕事

  土居雅夫; 岡村 均, Contributor, 生体リズムと現代病-時計遺伝子を活用して治療する

  化学同人, Mar. 2017, Not refereed

  
• 光と生命の事典

  土居雅夫, Contributor, 哺乳類の生物時計

  朝倉書店, 2016, Not refereed

  
• 時間生物学

  土居雅夫; 岡村 均, Contributor, 概日リズムと循環

  化学同人, Mar. 2012, Not refereed

  
• 生体リズム異常と原発性アルドステロン症

  岡村 均; 土居雅夫, Contributor, 生体リズム異常と原発性アルドステロン症

  診断と治療社, 2011, Not refereed

  

Industrial Property Rights

• 特許ZL202080047245.3, ニコチンアミドモノヌクレオチド（ＮＭＮ）およびニコチンアミドリボシド（ＮＲ）の新規用途

  
• 特許2822512, 特願2022101444, ニコチンアミドモノヌクレオチド（ＮＭＮ）およびニコチンアミドリボシド（ＮＲ）の新規用途

  

Awards

• 28 Mar. 2024

  (社) 日本薬学会, 薬学会学術振興賞

  加齢性疾患・生活習慣病治療に向けた時間生物学に基づく時間医薬科学の展開
• 23 Feb. 2011

  京都大学, 第3回湯川・朝永奨励賞
• 20 Apr. 2011

  文部科学省, 平成23年度科学技術分野の文部科学大臣表彰若手科学者賞
• 30 Mar. 2012

  (社) 日本薬学会, 平成24年度日本薬学会奨励賞
• 04 Feb. 2004

  (財) 井上科学振興財団, 第20回井上研究奨励賞
• 25 Mar. 2010

  (社) 日本内分泌学会, 第11回日本内分泌学会若手研究奨励賞
• 04 Feb. 2011

  (財) 井上科学振興財団, 第3回井上リサーチアウォード
• 20 Apr. 2017

  (社) 日本内分泌学会, 第37回日本内分泌学会研究奨励賞
• 02 Jun. 2017

  (財)臨床薬理研究振興財団, 第10回臨床薬理研究振興財団研究大賞
• 04 Feb. 2003

  (財) 井上科学振興財団, 第20回井上研究奨励賞
• 25 Mar. 2010

  (社) 日本内分泌学会, 第11回　若手研究奨励賞
• 04 Feb. 2011

  (財) 井上科学振興財団, 第3回井上リサーチアウォード
• 23 Feb. 2011

  京都大学, 第3回湯川・朝永奨励賞
• 20 Apr. 2011

  文部科学省, 平成23年度科学技術分野の文部科学大臣表彰若手科学者賞
• 30 Mar. 2012

  (社) 日本薬学会, 平成24年度日本薬学会奨励賞
• 20 Apr. 2017

  (社) 日本内分泌学会, 第37回日本内分泌学会研究奨励賞
• 02 Jun. 2017

  (財)臨床薬理研究振興財団, 第10回臨床薬理研究振興財団研究大賞

Media Coverage

• Newly discovered RNA sequence plays a role in temporal adaptation of circadian rhythm: A group from Kyoto University finds that changes in body temperature fine‐tune translational speed

  Science Japan, Apr. 2023

  
• 体内リズムの時刻合わせ役 新たなＲＮＡ配列発見

  科学新聞, 3面, Mar. 2023

  
• ののちゃんのＤＯ科学「体内時計」って何なの？

  朝日新聞, 朝刊5面, Jan. 2023

  
• まぶたの裏 ホルモン自給自足

  朝日新聞, 夕刊3面, Apr. 2022

  
• 男性ホルモン減 ドライアイに 京大などマウスのまぶたで確認

  読売新聞, 夕刊8面, Feb. 2022

  
• まぶたでステロイド 鍵は体内時計遺伝子

  京都新聞, 朝刊25面, Feb. 2022

  
• 世界も目が点⁉老化防止に光明

  テレビ大阪, やさしいニュース, Feb. 2022

  
• こつこつ観察日記 立派な研究

  朝日新聞, 朝刊27面, 30 Jul. 2021

  
• 京大グループ”ひたすら観察”

  京都新聞, 夕刊1面, 06 Jul. 2021

  
• 「ハカセの論文」 体内時計をコントロールするスイッチを発見

  京都リビング新聞, 2面, 28 Nov. 2020

  
• サイエンスbox シロー博士 生命のリズムを刻む体内時計

  読売新聞, 朝刊16面, 12 Jul. 2019

  
• 体内時計刻むDNA配列 たんぱく質無関係領域で発見

  日刊工業新聞, 朝刊29面, 13 Jun. 2019

  
• 体内時計支える重要DNA解明 京大など従来仮説、有力根拠

  京都新聞, 朝刊24面, 13 Jun. 2019

  
• 体内時計 スイッチはDNA配列 人間の朝型・夜型 解明の手がかりに 京大など

  朝日新聞, 朝刊3面, 13 Jun. 2019

  
• 「昼寝」遺伝子を発見 ヒトにも同様の働き？ 体温の調節に関与 京大准教授らハエ，マウスで確認

  読売新聞, 夕刊 12面, 17 Feb. 2018

  
• 昼寝の関連遺伝⼦、世界初発⾒ 体温調節でぐっすり

  京都新聞, 朝刊1面, 14 Feb. 2018

  
• 昼の眠気に影響？ 体温リズム調節の遺伝子を特定 京大

  朝日新聞, 朝刊33面, 14 Feb. 2018

  
• 体内時計に影響 遺伝子確認 京大チーム 新たな睡眠薬の候補物質研究へ

  産経新聞, 朝刊27面, 01 Mar. 2016

  
• 体内時計調節たんぱく質発見 京大 生活習慣病治療に道

  日刊工業新聞, 29面, 23 Feb. 2016

  
• 体内時計調律 新タンパク質 安全な睡眠薬開発に期待

  京都新聞, 朝刊24面, 18 Feb. 2016

  
• 目覚ましたんぱく 脳内に

  朝日新聞, 朝刊27面, 02 Jun. 2011

  
• 朝寝坊させない たんぱく質発見 京大、新薬開発に一役

  日本経済新聞, 夕刊14面, 25 May 2011

  
• 目覚まし遺伝子発現 京大教授ら マウス脳内、壊すと朝寝坊

  中日新聞, 夕刊12面, 25 May 2011

  
• 体内時計の正確なリズム形成 たんぱく質を特定

  日刊工業新聞, 25面, 25 May 2011

  
• 体内時計を調律 タンパク質発見 睡眠障害治療に道

  京都新聞, 朝刊23面, 25 May 2011

  
• “体内時計”司るタンパク質

  産経新聞, 朝刊24面, 25 May 2011

  
• 体内時計 調節たんぱく質

  読売新聞, 朝刊33面, 25 May 2011

  
• 体内時計に乱れ→高血圧 京大教授ら解明 副腎の酵素関与

  読売新聞, 朝刊38面, 15 Dec. 2009

  
• 高血圧、体の時計遺伝子が原因？ 京大グループ実験

  朝日新聞, 夕刊12面, 14 Dec. 2009

  
• 体内時計壊れ高血圧 京大発見 マウスから原因遺伝子

  毎日新聞, 夕刊12面, 14 Dec. 2009

  
• 不規則生活＋塩分＝高血圧 京大チーム解明

  産経新聞, 夕刊1面, 14 Dec. 2009

  
• 体内時計狂うと高血圧 不規則生活が原因 ホルモン過剰に 京大

  日本経済新聞, 夕刊14面, 14 Dec. 2009

  
• 体内時計乱れ 高血圧症に 京大グループ メカニズム解明 治療薬開発に期待

  京都新聞, 夕刊10面, 14 Dec. 2009

  
• 生体リズムの乱れが高血圧に マウスで解明、治療に期待

  共同通信, 14 Dec. 2009

  
• 夜更かし、狂う体内時計 夕暮れ以降の光 たんぱく質混乱

  朝日新聞, 朝刊3面, 08 Jun. 2004

  
• 体内時計 朝夕 別機構で調節 東大チームが仕組み解明

  読売新聞, 夕刊5面, 20 Aug. 2001

  
• 進みすぎの生物時計 調整にかぎ 東大グループ

  朝日新聞, 夕刊12面, 11 Jul. 2001

  

External funds: Kakenhi

• Tackling the Identification of Regulatory Mechanisms Determining Human Morningness/Eveningness Cnronotype Hidden in Non-Coding Genomic Regions

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 44:Biology at cellular to organismal levels, and related fields

  Kyoto University

  Masao Doi

  From 30 Jul. 2020, To 31 Mar. 2023, Project Closed

  体内時計;ノンコーディング;ノンコーディング領域;朝型夜型;睡眠

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21426/
• Parametric control of sleep, metabolism, and body clock via translation rate control

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (III)

  Kyoto University

  Masao Doi

  From 02 Oct. 2020, To 31 Mar. 2023, Project Closed

  体内時計;翻訳;uORF;体温

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-20H05783/
• Facilitation and development of parametric biology based on translation rate regulatory mechanism

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (III)

  Kyoto University

  Masao Doi

  From 02 Oct. 2020, To 31 Mar. 2023, Project Closed

  翻訳;パラメトリック制御;パレメトリック制御

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-20H05782/
• Parametric biology based on translation rate regulatory mechanism

  Grant-in-Aid for Transformative Research Areas (B)

  From 02 Oct. 2020, To 31 Mar. 2023, Project Closed

  https://kaken.nii.ac.jp/grant/KAKENHI-AREA-20B307/
• Circadian clock and proliferative metabolism in the intestinal T lymphocytes

  Grant-in-Aid for Scientific Research (C)

  Basic Section 54040:Metabolism and endocrinology-related

  Keio University

  Kenichiro Kinouchi

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  概日リズム;概日時計;代謝;エピジェネティックス;T細胞;体内時計

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K09012/
• Identification and characterization of a potential drug target regulating the pace of the central circadian clock in the brain through orphan G protein-coupled receptors

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Masao Doi

  From 01 Apr. 2017, To 31 Mar. 2022, Project Closed

  体内時計;G蛋白質共役受容体;生体時計;時計遺伝子;N型糖鎖修飾

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H01524/
• International research development of thermal biology

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Center for Novel Science Initatives, National Institutes of Natural Sciences;Okazaki Research Facilities, National Institutes of Natural Sciences

  Makoto Tominaga

  From 06 Nov. 2015, To 31 Mar. 2021, Project Closed

  温度生物学;生理学;神経科学

  https://kaken.nii.ac.jp/grant/KAKENHI-INTERNATIONAL-15K21744/
• Circadian regulation of sex steroids in aged skin after menopause

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Doi Masao

  From 01 Apr. 2015, To 31 Mar. 2016, Project Closed

  概日時計;皮膚;性ステロイド;ステロイド合成律速酵素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K15416/
• Elucidation of the role of circadian clock mechanisms in temperature sensing, temperature response and body temperature control in living organisms

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  Masao Doi

  From 29 Jun. 2015, To 31 Mar. 2020, Project Closed

  体内時計;体温;時計遺伝子;睡眠;G蛋白質共役受容体;視交叉上核;時間生物学;温度;生理学;神経科学;シグナル伝達;時計蛋白質

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-15H05933/
• Development of plasma steroid precursor-based new differential diagnosis and molecular targeted therapies for hyperaldosteronism

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Doi MASAO

  From 01 Apr. 2014, To 31 Mar. 2015, Project Closed

  アルドステロン;副腎;ステロイド合成酵素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26670174/
• Identification and characterization of a potential drug target regulating the pace of the central circadian clock in the brain

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Masao Doi

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  G蛋白質共役型受容体;体内時計;オーファン受容体;視交叉上核;G蛋白質共役受容体;概日時計;GPCR

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293013/
• Histone demethylase Jmjd1a as a regulator of glycolipid metabolism

  Grant-in-Aid for Young Scientists (A)

  The University of Tokyo

  Takeshi INAGAKI

  From 01 Apr. 2009, To 31 Mar. 2013, Project Closed

  エピゲノム;ヒストン脱メチル化酵素;Jmjd1a;糖脂質代謝調節;ヒストン;Jmjdla;肥満;ChIPシークエンス;RNAシークエンス;ヒストンメチル化;エビゲノム;H3K9;Jhdm2a;代謝;糖脂質代謝;ChIP

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21687013/
• 転写振動を支えるエピジェネティックな管理法則の同定と生体リズム調整剤の開発

  Grant-in-Aid for Young Scientists (A)

  Kyoto University

  土居 雅夫

  From 01 Apr. 2008, To 31 Mar. 2012, Project Closed

  遺伝子;発現制御;プロテオーム;神経科学;薬理学;高血圧;生体リズム;G蛋白質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20689002/
• 転写リズムを生成する核内機能複合体の同定と生体リズム調整剤の開発

  Grant-in-Aid for Young Scientists (B)

  Kyoto University;Kobe University

  土居 雅夫

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  生体リズム;遺伝子転写;PERIOD2;視交叉上核;PER10D2;視交叉上枝;GPCR

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18779004/
• Molecular Clocks to Biological Rhythms

  Grant-in-Aid for Specially Promoted Research

  Biological Sciences

  Kyoto University;Kobe University

  Hitoshi OKAMURA

  From 01 Apr. 2006, To 31 Mar. 2011, Project Closed

  時計遺伝子;視交叉上核;G蛋白質;臓器の時計;高血圧;神経科学;発現制御;生理学;脳科学;遺伝子;発光;皮膚;生体リズム;サーカディアンリズム;GPCR;振動子;ペプチド;腎尿細管;ヒートショックプロテイン;喘息;Flightless;Per2

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18002016/
• 細胞から個体までのリズム遺伝子発現の統合システムの解析

  Grant-in-Aid for Scientific Research (A)

  Kobe University

  岡村 均

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  時計遺伝子;Per2;コア・ループ;視交叉上核;副腎皮質ホルモン;転写

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17200024/
• Chronomedical inovation based on circadian biology

  Grant-in-Aid for Scientific Research (S)

  Broad Section H

  Kyoto University

  土居 雅夫

  From 27 Apr. 2022, To 31 Mar. 2027, Granted

  体内時計;生活習慣病;G蛋白質共役受容体;ステロイドホルモン;睡眠覚醒

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H04987/
• 生体リズムを基盤にした時間医薬科学の創成

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 47:Pharmaceutical sciences and related fields

  Kyoto University

  土居 雅夫

  From 01 Apr. 2022, To 31 Mar. 2023, Discontinued

  体内時計;G蛋白質共役受容体;時計遺伝子;不眠症;ドライアイ;生活習慣病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H00441/
• Elucidation of regulatory mechanisms of lipid metabolism in meibomian glands by changes in aging and indigenous bacterial flora

  Grant-in-Aid for Scientific Research (C)

  Basic Section 56060:Ophthalmology-related

  Kyoto Prefectural University of Medicine

  鈴木 智

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  Meibomian gland;MGD;Dry Eye;Microbiome;Lipidome;Sex Steroid Hormones;Sex steroid hormone;マイボーム腺;性ホルモン;常在細菌叢;加齢;脂質生合成

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K09771/
• Elucidation of neural circuits responsible for integrated output of central clock by sparse labeling

  Grant-in-Aid for JSPS Fellows

  Basic Section 47040:Pharmacology-related

  Kyoto University

  土居 雅夫

  From 15 Nov. 2023, To 31 Mar. 2026, Granted

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23KF0246/
• 翻訳のパラメトリク制御に基づく時間タンパク質の発振・位相調節機構の解明

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  土居 雅夫

  From 01 Apr. 2024, To 31 Mar. 2029, Granted

  体内時計

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-24H02306/
• chronoproteinology

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Tokyo Metropolitan Institute of Medical Science

  吉種 光

  From 01 Apr. 2024, To 31 Mar. 2029, Granted

  時間生物学;概日時計;季節応答;質量分析

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-24H02299/
• Parametric biology based on translation rate regulatory mechanism

  Grant-in-Aid for Transformative Research Areas (B)

  From 02 Oct. 2020, To 31 Mar. 2023, Project Closed

  https://kaken.nii.ac.jp/grant/KAKENHI-AREA-20B307/

External funds: others

• 生体リズム学を基盤とする時間医薬イノベーション

  最先端・次世代研究開発支援プログラム

  From 2010, To 2013

  土居 雅夫

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Frontiers of Biology

  N477, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Sciences and Ethics

  U129, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Interdisciplinary Sciences

  Y101, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Medicinal Frontier Science B

  8210, Fall, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Pharmaceutical Biochemistry B

  8206, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  International Skills Practice B

  8304, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  International Skills Practice A

  8303, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutical Laboratory Coaching Practice B

  8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Practice in Medicinal Frontier Sciences

  4213, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Industry-academia Collaborative Internship B

  8306, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Industry-academia Collaborative Internship A

  8305, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Proposal Writing Practice B

  8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Training(Systems Biology)

  E817, Year-long, Faculty of Pharmaceutical Sciences, 14
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Training(Systems Biology)

  D157, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2024, To 31 Mar. 2025

  Physiology III (Clinical Physiology)

  C304, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Physiology I (Basic Physiology)

  C301, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Physiology 4 (Genomic medicine)

  A304, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Physiology 1 (Anatomical Physiology)

  A301, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Laboratory Techniques in Biological Chemistry

  1207, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Modern Life Sciences for Drug Discovery

  1027, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Basic Biological Chemistry II

  1214, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Critical Reading of Scientific Papers B

  8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Biochemistry

  8103, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Pharmaceutical Sciences III

  6007, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar in Medicinal Frontier Sciences

  2316, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Methods in Systems Biology & Drug Discovery

  7007, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Methods in Systems Biology & Drug Discovery

  7007, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Systems Biology & Drug Discovery

  7005, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Systems Biology & Drug Discovery

  7005, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Medicinal Frontier Sciences

  3215, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Frontier Science Research C

  8408, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Frontier Science Research B

  8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  ILAS Seminar-E2

  Z002, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Sciences and Ethics

  U129, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Frontiers of Biology

  N477, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Proposal Writing Practice B

  8403, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Pharmaceutical Biochemistry A

  8205, Fall, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Medicinal Frontier Sciences

  4213, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Industry-academia Collaborative Internship A

  8305, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  International Skills Practice A

  8303, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory Coaching Practice B

  8302, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Systems Biology)

  D157, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Systems Biology)

  B818, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Systems Biology)

  E817, Year-long, Faculty of Pharmaceutical Sciences, 14
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Systems Biology & Drug Discovery

  7005, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Systems Biology & Drug Dicovery

  5301, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Skill Development for Clinical Researches

  5103, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Medicinal Frontier Science Research B

  8407, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Medicinal Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Systems Biology & Drug Discovery

  7005, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Medicinal Frontier Sciences

  3215, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research Training(Systems Biology)

  8157, Year-long, Faculty of Pharmaceutical Sciences, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Basic Biological Chemistry I

  1213, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Biological Chemistry

  1207, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Modern Life Sciences for Drug Discovery

  1027, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar in Medicinal Frontier Sciences

  2316, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Critical Reading of Scientific Papers B

  8405, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Biochemistry

  8103, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Pharmaceutical Sciences III

  6007, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Methods in Systems Biology & Drug Discovery

  5501, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Methods in Systems Biology & Drug Discovery

  7007, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Methods in Systems Biology & Drug Discovery

  7007, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physiology 1 (Anatomical Physiology)

  A301, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physiology 4 (Genomic medicine)

  A304, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physiology III (Clinical Physiology)

  C304, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Physiology I (Basic Physiology)

  C301, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical Laboratory Coaching Practice A

  8301, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Modern Life Sciences for Drug Discovery

  1027, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Systems Biology & Drug Discovery

  7005, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Methods in Systems Biology & Drug Discovery

  7007, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Critical Reading of Scientific Papers A

  8404, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Practice in Medicinal Frontier Sciences

  4213, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Pharmaceutical Biochemistry B

  8206, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Pharmaceutical Biochemistry

  8103, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Skill Development for Clinical Researches

  5103, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Systems Biology & Drug Dicovery

  5301, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Pharmaceutical Sciences III

  6007, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Bioinformatics II: Lead Discovery

  1108, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Systems Biology)

  D157, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Systems Biology)

  B818, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Methods in Systems Biology & Drug Discovery

  7007, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar in Medicinal Frontier Sciences

  2316, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  ILAS Seminar-E2

  Z002, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Proposal Writing Practice A

  8402, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Pharmaceutical Sciences and Ethics

  U129, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Physiology III (Clinical Physiology)

  C304, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Frontiers of Biology

  N477, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Systems Biology & Drug Discovery

  7005, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Basic Biological Chemistry II

  1214, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Medical Frontier Science Research A

  8406, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Research Training(Systems Biology)

  8157, Year-long, Faculty of Pharmaceutical Sciences, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Medicinal Frontier Sciences

  3215, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Physiology 4 (Genomic medicine)

  A304, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Methods in Systems Biology & Drug Discovery

  5501, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From Apr. 2011, To Mar. 2012

  薬学専門実習IV

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  薬学専門実習３

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  Bioinformatics II: Lead Discovery

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  The Role of Life Science in Drug Discovery

  Spring, 全学共通科目
• From Apr. 2011, To Mar. 2012

  一般生理学

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  Introduction to Modern Life Sciences

  Spring, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Advanced Methods in Systems

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Advanced Methods in Systems

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Research in Systems

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Research in Systems

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  生理学４（病態ゲノム学）

  Spring, 薬学部
• From Apr. 2011, To Mar. 2012

  生理学３（病態生理学）

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  生理学１（解剖生理学）

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  病態生理学

  Fall, 薬学部
• From Apr. 2011, To Mar. 2012

  Skill Development for

  Year-long, 薬学研究科
• From Apr. 2011, To Mar. 2012

  Skill Development for

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  General Physiology

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Bioinformatics II: Lead Discovery

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Introduction to Modern Life Sciences

  Spring, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Physiology 4 (Genomic medicine)

  Spring, 薬学部
• From Apr. 2012, To Mar. 2013

  Physiology 3 (Pathophysiology for drug discovery and personalized medicine)

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Physiology 1 (Anatomical Physiology)

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Pathogenesis of major symptoms and signs

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Skill Development for Clinical Researches

  Year-long, 薬学研究科
• From Apr. 2012, To Mar. 2013

  Pharmaceutical Laboratory III: Biochemistry and Microbiology

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2012, To Mar. 2013

  The Role of Life Science in Drug Discovery

  Spring, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Physiology 1 (Anatomical Physiology)

  Fall, 薬学部
• From Apr. 2013, To Mar. 2014

  Physiology 3 (Pathophysiology for drug discovery and personalized medicine)

  Fall, 薬学部
• From Apr. 2013, To Mar. 2014

  Physiology 4 (Genomic medicine)

  Spring, 薬学部
• From Apr. 2013, To Mar. 2014

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2013, To Mar. 2014

  Introduction to Modern Life Sciences

  Spring, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Skill Development for Clinical Researches

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2013, To Mar. 2014

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Physiology 1 (Anatomical Physiology)

  Fall, 薬学部
• From Apr. 2014, To Mar. 2015

  Physiology 3 (Pathophysiology for drug discovery and personalized medicine)

  Fall, 薬学部
• From Apr. 2014, To Mar. 2015

  Physiology 4 (Genomic medicine)

  Spring, 薬学部
• From Apr. 2014, To Mar. 2015

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2014, To Mar. 2015

  Introduction to Modern Life Sciences

  Spring, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Bioinformatics II: Lead Discovery

  Spring, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Skill Development for Clinical Researches

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2014, To Mar. 2015

  The Role of Life Science in Drug Discovery

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Introduction to Modern Life Sciences

  Spring, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Physiology 4 (Genomic medicine)

  Spring, 薬学部
• From Apr. 2015, To Mar. 2016

  Physiology 3 (Pathophysiology for drug discovery and personalized medicine)

  Fall, 薬学部
• From Apr. 2015, To Mar. 2016

  Physiology 1 (Anatomical Physiology)

  Fall, 薬学部
• From Apr. 2015, To Mar. 2016

  Skill Development for Clinical Researches

  Year-long, 薬学研究科
• From Apr. 2015, To Mar. 2016

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2015, To Mar. 2016

  The Role of Life Science in Drug Discovery

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Bioinformatics II: Lead Discovery

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Introduction to Modern Life Sciences

  Spring, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Physiology 4 (Genomic medicine)

  Spring, 薬学部
• From Apr. 2016, To Mar. 2017

  Physiology 3 (Pathophysiology for drug discovery and personalized medicine)

  Fall, 薬学部
• From Apr. 2016, To Mar. 2017

  Physiology 1 (Anatomical Physiology)

  Fall, 薬学部
• From Apr. 2016, To Mar. 2017

  Skill Development for Clinical Researches

  Year-long, 薬学研究科
• From Apr. 2016, To Mar. 2017

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2017, To Mar. 2018

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Physiology 4 (Genomic medicine)

  Spring, 薬学部
• From Apr. 2017, To Mar. 2018

  Physiology 3 (Pathophysiology for drug discovery and personalized medicine)

  Fall, 薬学部
• From Apr. 2017, To Mar. 2018

  Physiology 1 (Anatomical Physiology)

  Fall, 薬学部
• From Apr. 2017, To Mar. 2018

  Skill Development for Clinical Researches

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2018, To Mar. 2019

  Bioinformatics II: Lead Discovery

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Basic Biological Chemistry II

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research Training(Systems Biology)

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Research Training(Systems Biology)

  Year-long, 薬学部
• From Apr. 2018, To Mar. 2019

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Physiology I (Basic Physiology)

  Fall, 薬学部
• From Apr. 2018, To Mar. 2019

  Physiology 4 (Genomic medicine)

  Spring, 薬学部
• From Apr. 2018, To Mar. 2019

  Skill Development for Clinical Researches

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Introduction to Clinical Pharmacy

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2018, To Mar. 2019

  Advanced Pharmaceutical Sciences III

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Basic Biological Chemistry I

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research Training(Systems Biology)

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Research Training(Systems Biology)

  Year-long, 薬学部
• From Apr. 2019, To Mar. 2020

  Frontiers of Biology

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Advanced Methods in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Methods in Systems Biology & Drug Discovery

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Dicovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Dicovery

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Discovery

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Physiology III (Clinical Physiology)

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Physiology I (Basic Physiology)

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Physiology 4 (Genomic medicine)

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Physiology 1 (Anatomical Physiology)

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Skill Development for Clinical Researches

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Advanced Pharmaceutical Sciences III

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Bioinformatics II: Lead Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Basic Biological Chemistry II

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research Training(Systems Biology)

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Research Training(Systems Biology)

  Year-long, 薬学部
• From Apr. 2020, To Mar. 2021

  Frontiers of Biology

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Methods in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Methods in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Methods in Systems Biology & Drug Discovery

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Methods in Systems Biology & Drug Discovery

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Dicovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Dicovery

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Systems Biology & Drug Discovery

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Physiology III (Clinical Physiology)

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Physiology I (Basic Physiology)

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Physiology 4 (Genomic medicine)

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Physiology I (Anatomical Physiology)

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Skill Development for Clinical Researches

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Advanced Pharmaceutical Sciences III

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Introduction to Modern Life Sciences for Drug Discovery

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Basic Biological Chemistry I

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research Training(Systems Biology)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Research Training(Systems Biology)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Research Training(Systems Biology)

  Year-long, 薬学部
• From Apr. 2021, To Mar. 2022

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Methods in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Methods in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Systems Biology & Drug Dicovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Systems Biology & Drug Discovery

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Systems Biology & Drug Discovery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Physiology III (Clinical Physiology)

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Physiology I (Basic Physiology)

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Physiology 4 (Genomic medicine)

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Physiology I (Anatomical Physiology)

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Skill Development for Clinical Researches

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Introduction to Clinical Pharmacy

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Introduction to Pharmaceutical Sciences and Ethics

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Advanced Pharmaceutical Sciences III

  Spring, 薬学研究科

Participation in PhD Defense

• Chronopharmacological manipulation of Ang II-regulatable cell autonomous oscillators in adrenal zona glomerulosa cells

  OTANI TOMOHIRO, Graduate School of Pharmaceutical Sciences, Chief Examiner

  24 Mar. 2025
• Molecular basis of skeletal ciliopathies caused by mutations in intraflagellar transport complex subunits

  ISHIDA YAMATO, Graduate School of Pharmaceutical Sciences, Chief Examiner

  24 Mar. 2025
• 感覚機能の制御における末梢・中枢神経細胞TRPチャネルの役割に関する研究

  TOBORI SHOTA, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  24 Mar. 2025
• Tissue-Endogenous Intracrine Steroid Hormone Deactivation Machinery in the Meibomian Gland

  Nguyen Pham Khanh Tien, Graduate School of Pharmaceutical Sciences, Chief Examiner

  24 Mar. 2025
• Translation-Mediated Regulatory Mechanisms Regulating Light- and Temperature-Dependent Circadian Gene Expression

  XINYAN SHAO, Graduate School of Pharmaceutical Sciences, Chief Examiner

  24 Mar. 2025
• Regulation of daily rest timing via G-protein cAMP signaling in the brain central circadian clock

  TANAKA YOUICHI, Graduate School of Pharmaceutical Sciences, Chief Examiner

  24 Mar. 2025
• 肝臓特異的Ccdc47欠損マウスの作出と小胞体ストレス誘導剤ツニカマイシンに対する応答の検討

  NAKAJIMA NOBUHISA, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  25 Mar. 2024
• Regulation of the orphan receptor Gpr176 activity via post-translational modifications in the central circadian clock

  WANG TIANYU, Graduate School of Pharmaceutical Sciences, Chief Examiner

  23 Mar. 2023
• 強迫性障害の治療メカニズムに関する研究

  HATAKAMA HIKARI, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2023
• Molecular basis of Bardet-Biedl syndrome caused by defects of intraflagellar transport complex IFT-B

  ZHOU ZHUANG, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  26 Sep. 2022
• Mechanism of thermal entrainment of the circadian clock by newly identified post-transcriptional regulation

  INOUE YUICHI, Graduate School of Pharmaceutical Sciences, Chief Examiner

  23 Mar. 2022
• C-type natriuretic peptide facilitates autonomous Ca2+ entry in growth plate chondrocytes for stimulating bone growth （C型ナトリウム利尿ペプチドは自発的なCa2+流入を介して骨伸長を促進する）

  MIYAZAKI YUU, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2022
• Regulation of Siesta by the Central Circadian Clock in the Brain and its Physiological Role in Memory Consolidation

  MAEKAWA YOTA, Graduate School of Pharmaceutical Sciences, Chief Examiner

  23 Mar. 2022
• 情動行動を司る背側縫線核セロトニン神経の役割に関する研究

  NAGAI YUMA, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2022
• 臨床ビッグデータ解析と薬理学的実証を用いたドパミンD2受容体遮断薬誘発多動性障害抑制法の創出

  NAGAOKA KOKI, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2022
• 報酬および疼痛制御を担う神経機構に関する研究

  KAWAI HIROYUKI, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2022
• 慢性疼痛に関与するLPA合成酵素の役割とその阻害薬探索に関する研究

  TANAKA KEIGO, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2022
• Studies on the mechanism of ciliary protein localization and the molecular basis of ciliopathies

  HANTIAN QIU, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  24 Sep. 2021
• Reverse translational research to investigate the mechanisms underlying insomnia with depression and to develop an algorithm for selecting hypnotics

  SHIGETSURA YUKI, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2022
• ナノスケール液体クロマトグラフィー/イオンモビリティスペクトロメトリー/タンデム質量分析によるリン酸化ペプチド大規模解析に関する研究

  OGATA KOSUKE, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  23 Mar. 2022

Student achievements: Awards

• 第145回日本薬学会年会学生優秀発表賞

  田中陽一, 27 Mar. 2025
• Amgen Scholars Asia Symposium 優秀発表賞

  Amogh Varshney, 02 Aug. 2024
• 第144回日本薬学会年会学生優秀発表賞

  大谷知寛, 29 Mar. 2024
• 第144回日本薬学会年会学生優秀発表賞

  藤田悠人, 29 Mar. 2024
• 第142回日本薬学会年会学生優秀発表賞

  濵田悠貴, 28 Mar. 2022
• 松尾研究奨励賞

  嶋谷寛之, GPCR研究会, 29 Jun. 2018

Administration

School management (title, position)

• From 01 Oct. 2021, To 31 Mar. 2023

  大学院院教育支援機構 大学院共通・横断教育企画評価専門委員会 委員
• From 01 Apr. 2022, To 31 Mar. 2023

  国際高等教育院 企画評価専門委員会 生物学部会 委員
• From 01 Apr. 2021, To 31 Mar. 2023

  国際高等教育院 企画評価専門委員会 委員
• From 01 Apr. 2021, To 30 Sep. 2021

  国際高等教育院 基盤企画評価専門委員会 委員
• From 01 Apr. 2021, To 31 Mar. 2022

  国際高等教育院 企画評価専門委員会 生物学部会 委員
• From 01 Apr. 2021, To 31 Mar. 2022

  障害者入試委員会 委員
• From 28 Oct. 2020, To 30 Sep. 2022

  研究戦略タスクフォース プログラムオフィサー
• From 01 Jan. 2020, To 31 Dec. 2020

  オープンキャンパス委員会 委員
• From 01 Apr. 2019, To 31 Mar. 2021

  国際高等教育院 企画評価専門委員会 委員
• From 01 Apr. 2019, To 31 Mar. 2021

  国際高等教育院 基盤企画評価専門委員会 委員
• From 01 Apr. 2019, To 31 Mar. 2021

  国際高等教育院 企画評価専門委員会 生物学部会 委員
• From 01 Apr. 2019, To 31 Mar. 2021

  組換えＤＮＡ実験安全委員会 委員
• From 01 Apr. 2017, To 31 Mar. 2019

  組換えＤＮＡ実験安全委員会 1号委員
• From 01 May 2016, To 31 Mar. 2019

  国際高等教育院 企画評価専門委員会 英語部会 委員

Faculty management (title, position)

• From 01 Apr. 2023, To 31 Mar. 2025

  動物実験委員会　委員
• From 01 Apr. 2023, To 31 Mar. 2025

  教務委員会　委員
• From 01 Apr. 2023, To 31 Mar. 2025

  産学共同講座「ナノバイオ医薬創成科学講座」運営委員
• From 01 Apr. 2024, To 31 Mar. 2025

  iSAL薬学運営委員会　委員
• From 01 Apr. 2022, To 31 Mar. 2025

  将来計画委員会　委員
• From 01 Apr. 2023, To 31 Mar. 2025

  ハラスメント相談窓口
• From 01 Apr. 2024, To 31 Mar. 2025

  実験動物施設運営委員会　委員長
• From 01 Apr. 2023, To 31 Mar. 2025

  人権委員会　委員
• From 01 Apr. 2023, To 31 Mar. 2024

  実験動物管理委員会　委員長
• From 01 Apr. 2011, To 31 Mar. 2013

  共用試験委員会　委員
• From 01 Apr. 2012, To 31 Mar. 2015

  有機廃液処理実行委員　委員
• From 01 Apr. 2015, To 31 Mar. 2017

  学生委員　委員
• From 01 Apr. 2011, To 31 Mar. 2017

  図書委員会　委員
• From 01 Oct. 2012, To 31 Mar. 2019

  教務委員会　委員
• From 01 Apr. 2011, To 31 Mar. 2013

  ＲＩ管理委員会　委員
• From 01 Apr. 2020, To 31 Mar. 2021

  就職委員
• From 01 Apr. 2019, To 31 Mar. 2021

  学生委員　委員
• From 01 Apr. 2021, To 31 Mar. 2023

  動物実験委員会　委員長