Basic Information

Faculty

• 理学部

Professional Memberships

• THE BIOPHYSICAL SOCIETY OF JAPAN
• THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
• The Nuclear Magnetic Resonance Society of Japan

Academic Degree

• 修士（理学）(大阪大学)
• 博士（理学）(大阪大学)

Academic Resume (Graduate Schools)

• 大阪大学, 大学院理学研究科有機化学専攻前期課程, 卒業
• 大阪大学, 大学院理学研究科生物化学専攻後期課程, 修了

Academic Resume (Undergraduate School/Majors)

• 大阪大学, 理学部化学科, 卒業

High School

• High School

  兵庫県立龍野高等学校

Research History

• From Jul. 2014, To Present

  Kyoto University, Graduate School of Science, Professor
• From Mar. 2008, To Jun. 2014

  Kyoto University, Graduate School of Engineering, Associate Professor
• From Apr. 2001, To Mar. 2008

  Yokohama City University, Assistant Professor
• From Apr. 1998, To Mar. 2001

  The Hong Kong University of Science & Technology, Depart of Biochemistry, Research Associate

ID,URL

• ORCID ID

  0000-0003-3843-3330

• J-Global ID

  201301007949375647

researchmap URL

• https://researchmap.jp/tochio

Research

Research Topics, Overview of the research

• Research Topics

  Protein NMR
  Structural Biology(Innate immunity, inflammation, ubiquitin)

• Overview of the research

  Studying structure and function of biologically important proteins.

Research Interests

• NMR
• Structural Biology
• Innate Immunity
• in-cell NMR
• Ubiquitin chain
• MyD88

Research Areas

• Life sciences, Structural biochemistry
• Life sciences, Immunology
• Life sciences, Biophysics
• Nanotechnology/Materials, Molecular biochemistry

Papers

• From Monomers to Oligomers: Structural Mechanism of Receptor-Triggered MyD88 Assembly in Innate Immune Signaling

  Kazuki Kasai; Kayo Imamura; Masatoshi Uno; Naotaka Sekiyama; Tomoko Miyata; Fumiaki Makino; Ryusei Yamada; Yoshiki Takahashi; Noriyuki Kodera; Keiichi Namba; Hidenori Ohnishi; Akihiro Narita; Hiroki Konno; Hidehito Tochio

  18 Sep. 2024

  
• Interaction modes of human orexin 2 receptor with selective and nonselective antagonists studied by NMR spectroscopy

  Kayo Imamura; Ken-Ichi Akagi; Yohei Miyanoiri; Hirokazu Tsujimoto; Takatsugu Hirokawa; Hideo Ashida; Kaori Murakami; Asuka Inoue; Ryoji Suno; Takahisa Ikegami; Naotaka Sekiyama; So Iwata; Takuya Kobayashi; Hidehito Tochio

  Structure, Jan. 2024

  
• SUMO化Ad4BP/SF-1に結合する転写制御複合体の精製と解析

  土屋 惠; 磯貝 信; 谷口 浩章; 杤尾 豪人; 白川 昌宏; 諸橋 憲一郎; 平岡 泰; 原口 徳子; 小川 英知

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• ALS mutations in the TIA-1 prion-like domain trigger highly condensed pathogenic structures

  Naotaka Sekiyama; Kiyofumi Takaba; Saori Maki-Yonekura; Ken-ichi Akagi; Yasuko Ohtani; Kayo Imamura; Tsuyoshi Terakawa; Keitaro Yamashita; Daigo Inaoka; Koji Yonekura; Takashi S. Kodama; Hidehito Tochio

  Proceedings of the National Academy of Sciences, 20 Sep. 2022

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• MS4-9 自然免疫系細胞内アダプター分子の構造生物学的機能解析と臨床応用への展望(アレルゲン,免疫療法,ウイルス免疫, 第19回日本アレルギー学会春季臨床大会)

  名田 匡利; 大西 秀典; 相馬 和佳; 李 愛蓮; 加藤 善一郎; 金子 英雄; 近藤 直実; 杤尾 豪人; 白川 昌宏

  アレルギー, 2007

  
• 分子生物学的アプローチの臨床へのインパクト : IL-18及びシグナル伝達系タンパク質構造解析に基づく創薬へのアプローチ

  大西 秀典; 加藤 善一郎; 李 愛蓮; 木村 豪; 名田 匡利; 徳見 哲司; 相馬 和佳; 松井 永子; 金子 英雄; 近藤 直実; 杤尾 豪人; 白川 昌宏

  日本小児アレルギー学会誌 = The Japanese journal of pediatric allergy and clinical immunology, 10 Mar. 2008

  
• S1f2-3 In vitro and in cell NMR studies of modifier proteins(S1-f2: "Functions and dynamics of protein systems in various aspect",Symposia,Abstract,Meeting Program of EABS & BSJ 2006)

  Shirakawa Masahiro; Sakai Tomomi; Tochio Hidehito; Kokubo Tetsuro; Ki Sewon; Sugihara Fuminori; Baba Daichi; Hiroaki Hidekazu

  Seibutsu Butsuri, 2006

  
• 2P127 SUMO-3 (Small Ubiquitin-like Modifier) Recognition by a SUMO Binding Motif(31. Protein folding and misfolding (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

  Sekiyama Naotaka; Saitoh Toshihito; Ikegami Takahisa; Tochio Hidehito; Shirakawa Masahiro

  Seibutsu Butsuri, 2006

  
• 1P323 Molecular basis of microtubule disassembly mechanism regulated by katanin p60(10. Cytoskeleton,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

  Iwaya Naoko; Unzai Satoru; Tomii Kentaro; Goda Natsuko; Tochio Hidehito; Shirakawa Masahiro; Hiroaki Hidekazu

  Seibutsu Butsuri, 2006

  
• Crystal structure of the extracellular signaling complex of interleukin-18

  Naotaka Tsutsumi; Takeshi Kimura; Kyohei Arita; Mariko Ariyoshi; Hidenori Ohnishi; Takahiro Yamamoto; Xiaobing Zuo; Naomi Kondo; Masahiro Shirakawa; Zenichiro Kato; Hidehito Tochio

  Acta Crystallographica Section A Foundations and Advances, 05 Aug. 2014

  
• 122 アレルギー病態における細胞内シグナル伝達機構のタンパク構造学的基盤(自然免疫,一般演題(口演),第56回日本アレルギー学会秋季学術大会)

  大西 秀典; 杤尾 豪人; 加藤 善一郎; 李 愛蓮; 白川 昌宏; 近藤 直実

  アレルギー, 2006

  
• 1SF04 SUMOylation of a DNA repair protein

  Shirakawa M.; Baba D.; Maita N.; Saito H.; Uchimura Y.; Sugasawa K.; Hanaoka F.; Tochio H.; Hiroaki H.

  Seibutsu Butsuri, 2005

  
• 1P100 Dynamics of MBD1-MBD/Methylated DNA complex

  Inomata K.; Ohki I.; Shimotake N.; Fujiwara K.; Tochio H.; Shirakawa M.

  Seibutsu Butsuri, 2004

  
• 2P-020 Structural study on molecular switching mechanism by phosphorylation of Sld2(Protein:Structure & Function,The 47th Annual Meeting of the Biophysical Society of Japan)

  Abe Shogo; Ariyoshi Mariko; Tochio Hidehito; Araki Hiroyuki; Shirakawa Masahiro

  Seibutsu Butsuri, 2009

  
• 3P019 Structural and thermodynamic analyses of histone H3 recognition by UHRF1(Protein: Structure,The 48th Annual Meeting of the Biophysical Society of Japan)

  Sugita Kazuya; Arita Kyohei; Unoki Motoko; Ariyoshi Mariko; Tochio Hidehito; Hamamoto Ryuji; Shirakawa Masahiro

  Seibutsu Butsuri, 2010

  
• 1P-044 Thermodynamic analysis of the hemi-methylated CpG DNA recognition by SRA domain of mouse NP95(The 46th Annual Meeting of the Biophysical Society of Japan)

  Sugita Kazuya; Arita Kyohei; Ariyoshi Mariko; Tochio Hidehito; Nakamura Yusuke; Shirakawa Masahiro

  Seibutsu Butsuri, 2008

  
• 1P-043 The Ubiquitin Associated Domain Of p62 In The Solution Exists In A Monomer-Dimer Equilibrium(The 46th Annual Meeting of the Biophysical Society of Japan)

  Morimoto Daichi; Isogai Shin; Abe Shogo; Tenno Takeshi; Arita Kyohei; Ariyoshi Mariko; Tochio Hidehito; Tanaka Keiji; Shirakawa Masahiro

  Seibutsu Butsuri, 2008

  
• S2N2 The interaction between PSD-95 PDZ domain and the target molecules

  Tochio H.; Qiang Zhaug; Li Ming; Zhang Mingjie

  Seibutsu Butsuri, 2002

  
• Characterizing conformational ensembles of multi-domain proteins using anisotropic paramagnetic NMR restraints

  Xue-Ni Hou; Hidehito Tochio

  Biophysical Reviews, Feb. 2022

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• Conformational Space Sampled by Domain Reorientation of Linear Diubiquitin Reflected in Its Binding Mode for Target Proteins

  Xue‐Ni Hou; Naotaka Sekiyama; Yasuko Ohtani; Feng Yang; Yohei Miyanoiri; Ken‐ichi Akagi; Xun‐Cheng Su; Hidehito Tochio

  ChemPhysChem, 16 Jul. 2021, Peer-reviewed

  
• Tracking the 3D Rotational Dynamics in Nanoscopic Biological Systems

  Ryuji Igarashi; Takuma Sugi; Shingo Sotoma; Takuya Genjo; Yuta Kumiya; Erik Walinda; Hiroshi Ueno; Hitoshi Sumiya; Hidehito Tochio; Yohsuke Yoshinari; Yoshie Harada; Masahiro Shirakawa

  Journal of the American Chemical Society, Apr. 2020, Peer-reviewed

  
• Contribution of Coiled-Coil Assembly to Ca2+/Calmodulin-Dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-Associated Phenotypes

  Onur K. Polat; Masatoshi Uno; Terukazu Maruyama; Ha Nam Tran; Kayo Imamura; Chee Fah Wong; Reiko Sakaguchi; Mariko Ariyoshi; Kyohei Itsuki; Jun Ichikawa; Takashi Morii; Masahiro Shirakawa; Ryuji Inoue; Katsuhiko Asanuma; Jochen Reiser; Hidehito Tochio; Yasuo Mori; Masayuki X. Mori

  Journal of the American Society of Nephrology, Sep. 2019, Peer-reviewed

  
• An innate interaction between IL-18 and the propeptide that inactivates its precursor form.

  Tsutsumi N; Yokota A; Kimura T; Kato Z; Fukao T; Shirakawa M; Ohnishi H; Tochio H

  Scientific reports, Apr. 2019, Peer-reviewed

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• Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization

  Hiroaki Fujita; Akira Tokunaga; Satoshi Shimizu; Amanda L. Whiting; Francisco Aguilar-Alonso; Kenji Takagi; Erik Walinda; Yoshiteru Sasaki; Taketo Shimokawa; Tsunehiro Mizushima; Izuru Ohki; Mariko Ariyoshi; Hidehito Tochio; Federico Bernal; Masahiro Shirakawa; Kazuhiro Iwai

  Cell Reports, 24 Apr. 2018, Peer-reviewed

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• Ca2+-Dependent Inactivation Mediated by Calmodulin in TRPC6 Channel Underlies FSGS Channelopathy

  Masatoshi Uno; Onur K. Polat; Ha Nam Tran; Shota Yamaji; Yasuo Mori; Hidehito Tochio; Masayuki X. Mori

  BIOPHYSICAL JOURNAL, Feb. 2018

  
• Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88

  Masatoshi Uno; Takahiro Watanabe-Nakayama; Hiroki Konno; Ken-ichi Akagi; Naotaka Tsutsumi; Toshiyuki Fukao; Masahiro Shirakawa; Hidenori Ohnishi; Hidehito Tochio

  Chemical Communications, 2018, Peer-reviewed

  
• Hexaphyrin as a Potential Theranostic Dye for Photothermal Therapy and F-19 Magnetic Resonance Imaging

  Tomohiro Higashino; Hirotaka Nakatsuji; Ryosuke Fukuda; Haruki Okamoto; Hirohiko Imai; Tetsuya Matsuda; Hidehito Tochio; Masahiro Shirakawa; Nikolai V. Tkachenko; Mitsuru Hashida; Tatsuya Murakami; Hiroshi Imahori

  CHEMBIOCHEM, May 2017, Peer-reviewed

  
• Selective Labeling of Proteins on Living Cell Membranes Using Fluorescent Nanodiamond Probes

  Shingo Sotoma; Jun Iimura; Ryuji Igarashi; Koichiro M. Hirosawa; Hidenori Ohnishi; Shin Mizukami; Kazuya Kikuchi; Takahiro K. Fujiwara; Masahiro Shirakawa; Hidehito Tochio

  NANOMATERIALS, Apr. 2016, Peer-reviewed

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• Structural analysis of the TKB domain of ubiquitin ligase Cbl-b complexed with its small inhibitory peptide, Cblin

  Ayako Ohno; Arisa Ochi; Nobuo Maita; Tatsuya Ueji; Aki Bando; Reiko Nakao; Katsuya Hirasaka; Tomoki Abe; Shigetada Teshima-Kondo; Hisao Nemoto; Yuushi Okumura; Akira Higashibata; Sachiko Yano; Hidehito Tochio; Takeshi Nikawa

  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Mar. 2016, Peer-reviewed

  
• UCP3 is associated with Hax-1 in mitochondria in the presence of calcium ion

  Katsuya Hirasaka; Edward M. Mills; Marie Haruna; Aki Bando; Chika Ikeda; Tomoki Abe; Shohei Kohno; Sara M. Nowinski; Cory U. Lago; Ken-ichi Akagi; Hidehito Tochio; Ayako Ohno; Shigetada Teshima-Kondo; Yuushi Okumura; Takeshi Nikawa

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Mar. 2016, Peer-reviewed

  
• ナノダイヤモンドNVCを使った新しい生体・細胞計測法 (特集 新しい光学技術 : 生体とダイヤモンドにフォーカス)

  五十嵐 龍治; 杤尾 豪人; 白川 昌宏

  光技術コンタクト = Optical and electro-optical engineering contact, Jan. 2016

  
• Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation

  Megumi Tsuchiya; Shin Isogai; Hiroaki Taniguchi; Hidehito Tochio; Masahiro Shirakawa; Ken-ichirou Morohashi; Yasushi Hiraoka; Tokuko Haraguchi; Hidesato Ogawa

  SCIENTIFIC REPORTS, Sep. 2015, Peer-reviewed

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• Non-invasive analysis of proteins in living cells using nmr spectroscopy

  Hidehito Tochio; Shuhei Murayama; Kohsuke Inomata; Daichi Morimoto; Ayako Ohno; Masahiro Shirakawaa

  Yakugaku Zasshi, 01 Mar. 2015, Peer-reviewed

  
• Optically Detected Magnetic Resonance of Nanodiamonds In Vivo; Implementation of Selective Imaging and Fast Sampling

  Yosuke Yoshinari; Shigeyuki Mori; Ryuji Igarashi; Takuma Sugi; Hiroaki Yokota; Kazuhiro Ikeda; Hitoshi Sumiya; Ikue Mori; Hidehito Tochio; Yoshie Harada; Masahiro Shirakawa

  JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, Feb. 2015, Peer-reviewed

  
• Suppression of nonspecific protein-nanodiamond adsorption enabling specific targeting of nanodiamonds to biomolecules of interest

  Shingo Sotoma; Ryuji Igarashi; Jun Iimura; Yuta Kumiya; Hidehito Tochio; Yoshie Harada; Masahiro Shirakawa

  Chemistry Letters, 2015, Peer-reviewed

  
• Comprehensive and quantitative analysis for controlling the physical/chemical states and particle properties of nanodiamonds for biological applications

  S. Sotoma; K. Akagi; S. Hosokawa; R. Igarashi; H. Tochio; Y. Harada; M. Shirakawa

  RSC Advances, 2015, Peer-reviewed

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• The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates

  Daichi Morimoto; Erik Walinda; Harumi Fukada; Yu-Shin Sou; Shun Kageyama; Masaru Hoshino; Takashi Fujii; Hikaru Tsuchiya; Yasushi Saeki; Kyohei Arita; Mariko Ariyoshi; Hidehito Tochio; Kazuhiro Iwai; Keiichi Namba; Masaaki Komatsu; Keiji Tanaka; Masahiro Shirakawa

  Nature Communications, Jan. 2015, Peer-reviewed

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• Magnetic Resonance Imaging of Tumor with a Self-Traceable Phosphorylcholine Polymer

  Hisatsugu Yamada; Yoshinori Hasegawa; Hirohiko Imai; Yuki Takayama; Fuminori Sugihara; Tetsuya Matsuda; Hidehito Tochio; Masahiro Shirakawa; Shinsuke Sando; Yu Kimura; Akio Toshimitsu; Yasuhiro Aoyama; Teruyuki Kondo

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jan. 2015, Peer-reviewed

  
• The structural basis for receptor recognition of human interleukin-18

  Naotaka Tsutsumi; Takeshi Kimura; Kyohei Arita; Mariko Ariyoshi; Hidenori Ohnishi; Takahiro Yamamoto; Xiaobing Zuo; Katsumi Maenaka; Enoch Y. Park; Naomi Kondo; Masahiro Shirakawa; Hidehito Tochio; Zenichiro Kato

  NATURE COMMUNICATIONS, Dec. 2014, Peer-reviewed

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• Purification, crystallization and preliminary X-ray crystallographic analysis of human IL-18 and its extracellular complexes

  Takeshi Kimura; Naotaka Tsutsumi; Kyohei Arita; Mariko Ariyoshi; Hidenori Ohnishi; Naomi Kondo; Masahiro Shirakawa; Zenichiro Kato; Hidehito Tochio

  Acta Crystallographica Section F:Structural Biology Communications, 01 Oct. 2014, Peer-reviewed

  
• Purification, crystallization and preliminary X-ray crystallographic analysis of human IL-18 and its extracellular complexes

  Takeshi Kimura; Naotaka Tsutsumi; Kyohei Arita; Mariko Ariyoshi; Hidenori Ohnishi; Naomi Kondo; Masahiro Shirakawa; Zenichiro Kato; Hidehito Tochio

  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, Oct. 2014, Peer-reviewed

  
• Solution Structure of the Ubiquitin-associated ( UBA) Domain of Human Autophagy Receptor NBR1 and Its Interaction with Ubiquitin and Polyubiquitin

  Erik Walinda; Daichi Morimoto; Kenji Sugase; Tsuyoshi Konuma; Hidehito Tochio; Masahiro Shirakawa

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2014, Peer-reviewed

  
• Functional assessment of the mutational effects of human IRAK4 and MyD88 genes

  Takahiro Yamamoto; Naotaka Tsutsumi; Hidehito Tochio; Hidenori Ohnishi; Kazuo Kubota; Zenichiro Kato; Masahiro Shirakawa; Naomi Kondo

  MOLECULAR IMMUNOLOGY, Mar. 2014

  
• EAAS3-1 Structural basis for the receptor recognitions of interleukin-18(EAAS3 Innate/adaptive immunity and allergy,Free Paper Session 1,East Asia Allergy Symposium 2014)

  Ohnishi Hidenori; Tsutsumi Naotaka; Kimura Takeshi; Kondo Naomi; Shirakawa Masahiro; Tochio Hidehito; Kato Zenichiro

  Japanese Journal of Allergology, 2014

  
• Effective production of fluorescent nanodiamonds containing negatively-charged nitrogen-vacancy centers by ion irradiation

  Shingo Sotoma; Yohsuke Yoshinari; Ryuji Igarashi; Akiyoshi Yamazaki; Shige H. Yoshimura; Hidehito Tochio; Masahiro Shirakawa; Yoshie Harada

  Diamond and Related Materials, 2014, Peer-reviewed

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• Pruning the ALS-Associated Protein SOD1 for in-Cell NMR

  Jens Danielsson; Kohsuke Inomata; Shuhei Murayama; Hidehito Tochio; Lisa Lang; Masahiro Shirakawa; Mikael Oliveberg

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2013, Peer-reviewed

  
• 1SCP-05 Optically detected magnetic resonance spectroscopy of nitrogen-vacancy centers for subnanoscopic measurement in vivo(1SCP Challenges to in vivo biophysics,Symposium,The 51th Annual Meeting of the Biophysical Society of Japan)

  Igarashi Ryuji; Kumiya Yuta; Sugi Takuma; Sugihara Fuminori; Tochio Hidehito; Yoshinari Yousuke; Harada Yoshie; Shirakawa Masahiro

  Seibutsu Butsuri, 2013

  
• Quantitative comparison of protein dynamics in live cells and in vitro by in-cell F-19-NMR

  Yousuke Takaoka; Yoshiyuki Kioi; Akira Morito; Junji Otani; Kyohei Arita; Eishi Ashihara; Mariko Ariyoshi; Hidehito Tochio; Masahiro Shirakawa; Itaru Hamachi

  CHEMICAL COMMUNICATIONS, 2013, Peer-reviewed

  
• A Structured Monodisperse PEG for the Effective Suppression of Protein Aggregation

  Takahiro Muraoka; Kota Adachi; Mihoko Ui; Shunichi Kawasaki; Nabanita Sadhukhan; Haruki Obara; Hidehito Tochio; Masahiro Shirakawa; Kazushi Kinbara

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, Peer-reviewed

  
• Watching protein structure at work in living cells using NMR spectroscopy

  Hidehito Tochio

  CURRENT OPINION IN CHEMICAL BIOLOGY, Dec. 2012, Peer-reviewed

  
• Real-Time Background-Free Selective Imaging of Fluorescent Nanodiamonds in Vivo

  Ryuji Igarashi; Yohsuke Yoshinari; Hiroaki Yokota; Takuma Sugi; Fuminori Sugihara; Kazuhiro Ikeda; Hitoshi Sumiya; Shigenori Tsuji; Ikue Mori; Hidehito Tochio; Yoshie Harada; Masahiro Shirakawa

  NANO LETTERS, Nov. 2012, Peer-reviewed

  
• Molecular analysis of the binding mode of Toll/interleukin-1 receptor (TIR) domain proteins during TLR2 signaling

  Masatoshi Nada; Hidenori Ohnishi; Hidehito Tochio; Zenichiro Kato; Takeshi Kimura; Kazuo Kubota; Takahiro Yamamoto; Yuji O. Kamatari; Naotaka Tsutsumi; Masahiro Shirakawa; Naomi Kondo

  MOLECULAR IMMUNOLOGY, Oct. 2012, Peer-reviewed

  
• Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1

  Kyohei Arita; Shin Isogai; Takashi Oda; Motoko Unoki; Kazuya Sugita; Naotaka Sekiyama; Keiko Kuwata; Ryuji Hamamoto; Hidehito Tochio; Mamoru Sato; Mariko Ariyoshi; Masahiro Shirakawa

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2012, Peer-reviewed

  
• TRAM Is Involved in IL-18 Signaling and Functions as a Sorting Adaptor for MyD88

  Hidenori Ohnishi; Hidehito Tochio; Zenichiro Kato; Norio Kawamoto; Takeshi Kimura; Kazuo Kubota; Takahiro Yamamoto; Tatsuyoshi Funasaka; Hiroshi Nakano; Richard W. Wong; Masahiro Shirakawa; Naomi Kondo

  PLOS ONE, Jun. 2012, Peer-reviewed

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• NMR analysis of Lys63-linked polyubiquitin recognition by the tandem ubiquitin-interacting motifs of Rap80

  Naotaka Sekiyama; JunGoo Jee; Shin Isogai; Ken-ichi Akagi; Tai-huang Huang; Mariko Ariyoshi; Hidehito Tochio; Masahiro Shirakawa

  JOURNAL OF BIOMOLECULAR NMR, Apr. 2012, Peer-reviewed

  
• Substrate/Product-Targeted NMR Monitoring of Pyrimidine Catabolism and Its Inhibition by a Clinical Drug

  Hisatsugu Yamada; Keigo Mizusawa; Ryuji Igarashi; Hidehito Tochio; Masahiro Shirakawa; Yasuhiko Tabata; Yu Kimura; Teruyuki Kondo; Yasuhiro Aoyama; Shinsuke Sando

  ACS CHEMICAL BIOLOGY, Mar. 2012, Peer-reviewed

  
• Structural Analysis of Proteins in Living Eukaryotic Cells Using Magnetic Resonance Spectroscopy

  Hidehito Tochio; Masahiro Shirakawa

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Feb. 2012, Peer-reviewed

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• 2SB-02 Protein NMR spectroscopy in the cellular environment(2SB Symposium organized by younger generation: Young scientists pioneering future life sciences,Symposium,The 50th Annual Meeting of the Biophysical Society of Japan)

  Inomata Kohsuke; Murayama Shuhei; Futaki Shiro; Hiroaki Hidekazu; Ito Yutaka; Tochio Hidehito; Shirakawa Masahiro

  Seibutsu Butsuri, 2012

  
• Crystal Structure of the Ubiquitin-associated (UBA) Domain of p62 and Its Interaction with Ubiquitin

  Shin Isogai; Daichi Morimoto; Kyohei Arita; Satoru Unzai; Takeshi Tenno; Jun Hasegawa; Yu-shin Sou; Masaaki Komatsu; Keiji Tanaka; Masahiro Shirakawa; Hidehito Tochio

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2011, Peer-reviewed

  
• In-Cell NMR Spectroscopy in Protein Chemistry and Drug Discovery

  Ayako Ohno; Kohsuke Inomata; Hidehito Tochio; Masahiro Shirakawa

  CURRENT TOPICS IN MEDICINAL CHEMISTRY, Jan. 2011, Peer-reviewed

  
• クロマチン遺伝子制御研究の現状と将来 UHRF1によるエピジェネティックマークの読み取り機構の構造生物学的基盤

  有田 恭平; 杉田 和也; 鵜木 元香; 浜本 隆二; 有吉 真理子; 栃尾 豪人; 白川 昌宏

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2010, Peer-reviewed

  
• H-1, C-13, and N-15 resonance assignment of the TIR domain of human MyD88

  Hidenori Ohnishi; Hidehito Tochio; Zenichiro Kato; Takeshi Kimura; Hidekazu Hiroaki; Naomi Kondo; Masahiro Shirakawa

  BIOMOLECULAR NMR ASSIGNMENTS, Oct. 2010, Peer-reviewed

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• Turn-on Detection of Targeted Biochemical Reactions by Triple Resonance NMR Analysis Using Isotope-labeled Probe

  Keigo Mizusawa; Ryuji Igarashi; Kosei Uehira; Yoshimasa Takafuji; Yasuhiko Tabata; Hidehito Tochio; Masahiro Shirakawa; Shinsuke Sando; Yasuhiro Aoyama

  CHEMISTRY LETTERS, Sep. 2010, Peer-reviewed

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• Purification, crystallization and preliminary crystallographic studies of Lys48-linked polyubiquitin chains

  Daichi Morimoto; Shin Isogai; Takeshi Tenno; Hidehito Tochio; Masahiro Shirakawa; Mariko Ariyoshi

  ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Jun. 2010, Peer-reviewed

  
• Distance Determination in Proteins inside Xenopus laevis Oocytes by Double Electron-Electron Resonance Experiments

  Ryuji Igarashi; Tomomi Sakai; Hideyuki Hara; Takeshi Tenno; Toshiaki Tanaka; Hidehito Tochio; Masahiro Shirakawa

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 2010, Peer-reviewed

  
• Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase Mcm proteins.

  Jungoo Jee; Takeshi Mizuno; Katsuhiko Kamada; Hidehito Tochio; Yasumasa Chiba; Ken-Ichiro Yanagi; Gentaro Yasuda; Hidekazu Hiroaki; Fumio Hanaoka; Masahiro Shirakawa

  The Journal of biological chemistry, 21 May 2010, Peer-reviewed

  
• A Common Substrate Recognition Mode Conserved between Katanin p60 and VPS4 Governs Microtubule Severing and Membrane Skeleton Reorganization

  Naoko Iwaya; Yohta Kuwahara; Yoshie Fujiwara; Natsuko Goda; Takeshi Tenno; Kohei Akiyama; Shogo Mase; Hidehito Tochio; Takahisa Ikegami; Masahiro Shirakawa; Hidekazu Hiroaki

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2010, Peer-reviewed

  
• Structural basis for regulation of poly-SUMO chain by a SUMO-like domain of Nip45

  Naotaka Sekiyama; Kyohei Arita; Yoshihiro Ikeda; Kohtaro Hashiguchi; Mariko Ariyoshi; Hidehito Tochio; Hisato Saitoh; Masahiro Shirakawa

  PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, May 2010, Peer-reviewed

  
• Solution structure of a zinc-finger domain that binds to poly-ADP-ribose

  Shin Isogai; Shin-Ichiro Kanno; Mariko Ariyoshi; Hidehito Tochio; Yutaka Ito; Akira Yasui; Masahiro Shirakawa

  GENES TO CELLS, Feb. 2010, Peer-reviewed

  
• Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling

  Hidenori Ohnishi; Hidehito Tochio; Zenichiro Kato; Kenji E. Orii; Ailian Li; Takeshi Kimura; Hidekazu Hiroaki; Naomi Kondo; Masahiro Shirakawa

  Proceedings of the National Academy of Sciences of the United States of America, 23 Jun. 2009, Peer-reviewed

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• High-resolution multi-dimensional NMR spectroscopy of proteins in human cells

  Kohsuke Inomata; Ayako Ohno; Hidehito Tochio; Shin Isogai; Takeshi Tenno; Ikuhiko Nakase; Toshihide Takeuchi; Shiroh Futaki; Yutaka Ito; Hidekazu Hiroaki; Masahiro Shirakawa

  NATURE, Mar. 2009, Peer-reviewed

  
• Self-assembling nanoprobes that display off/on 19F nuclear magnetic resonance signals for protein detection and imaging

  Takaoka, Yousuke; Sakamoto, Takashi; Tsukiji, Shinya; Narazaki, Michiko; Matsuda, Tetsuya; Tochio, Hidehito; Shirakawa, Masahiro; Hamachi, Itaru

  Nature chemistry, 2009, Peer-reviewed

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• Molecular Basis for SUMOylation-dependent Regulation of DNA Binding Activity of Heat Shock Factor 2

  Yukihiro Tateishi; Mariko Ariyoshi; Ryuji Igarashi; Hideyuki Hara; Kenji Mizuguchi; Azusa Seto; Akira Nakai; Tetsuro Kokubo; Hidehito Tochio; Masahiro Shirakawa

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2009, Peer-reviewed

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• Structure of the small ubiquitin-like modifier (SUMO)-interacting motif of MBD1-containing chromatin-associated factor 1 bound to SUMO-3.

  Naotaka Sekiyama; Takahisa Ikegami; Tsutomu Yamane; Mitsunori Ikeguchi; Yasuhiro Uchimura; Daichi Baba; Mariko Ariyoshi; Hidehito Tochio; Hisato Saitoh; Masahiro Shirakawa

  The Journal of biological chemistry, 19 Dec. 2008, Peer-reviewed

  
• The solution structure of the C-terminal domain of NfeD reveals a novel membrane-anchored OB-fold

  Yohta Kuwahara; Ayako Ohno; Taichi Morii; Hideshi Yokoyama; Ikuo Matsui; Hidehito Tochio; Masahiro Shirakawa; Hidekazu Hiroaki

  PROTEIN SCIENCE, Nov. 2008, Peer-reviewed

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• Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

  Kyohei Arita; Mariko Ariyoshi; Hidehito Tochio; Yusuke Nakamura; Masahiro Shirakawa

  NATURE, Oct. 2008, Peer-reviewed

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• Kinetic and thermodynamic evidence for flipping of a methyl-CpG binding domain on methylated DNA

  Kosuke Inomata; Izuru Ohki; Hidehito Tochio; Kenichiro Fujiwara; Hidekazu Hiroaki; Masahiro Shirakawat

  BIOCHEMISTRY, Mar. 2008, Peer-reviewed

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• Paramagnetic relaxation-based F-19 MRI probe to detect protease activity

  Shin Mizukami; Rika Takikawa; Fuminori Sugihara; Yuichiro Hori; Hidehito Tochio; Markus Walchli; Masahiro Shirakawa; Kazuya Kikuchi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jan. 2008

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• Expression, purification and structural analysis of human IL-18 binding protein: A potent therapeutic molecule for allergy

  Takeshi Kimura; Zenichiro Kato; Hidenori Ohnishi; Hidehito Tochio; Masahiro Shirakawa; Naomi Kondo

  Allergology International, 2008, Peer-reviewed

  
• Fluoroscopic assessment of protein leakage during Xenopus oocytes in-cell NMR experiment by co-injected EGFP

  Tomorni Sakai; Hidehito Tochio; Kosuke Inomata; Yoshiyuki Sasaki; Takeshi Tenno; Toshiaki Tanaka; Tetsuro Kokubo; Hidekazu Hiroaki; Masahiro Shirakawa

  ANALYTICAL BIOCHEMISTRY, Dec. 2007, Peer-reviewed

  
• Magnetic resonance-based visualization of gene expression in mammalian cells using a bacterial polyphosphate kinase reporter gene

  Sewon Ki; Fuminori Sugihara; Koji Kasahara; Hidehito Tochio; Masahiro Shirakawa; Tetsuro Kokubo

  BIOTECHNIQUES, Feb. 2007, Peer-reviewed

  
• Fine-tuning of protein domain boundary by minimizing potential coiled coil regions

  Naoko Iwaya; Natsuko Goda; Satoru Unzai; Kenichiro Fujiwara; Toshiki Tanaka; Kentaro Tomii; Hidehito Tochio; Masahiro Shirakawa; Hidekazu Hiroaki

  JOURNAL OF BIOMOLECULAR NMR, Jan. 2007, Peer-reviewed

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• In-cell NMR spectroscopy of proteins inside Xenopus laevis oocytes

  Tomomi Sakai; Hidehito Tochio; Takeshi Tenno; Yutaka Ito; Tetsuro Kokubo; Hidekazu Hiroaki; Masahiro Shirakawa

  JOURNAL OF BIOMOLECULAR NMR, Nov. 2006, Peer-reviewed

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• Crystal structure of SUMO-3-modified thymine-DNA glycosylase.

  Daichi Baba; Nobuo Maita; Jun-Goo Jee; Yasuhiro Uchimura; Hisato Saitoh; Kaoru Sugasawa; Fumio Hanaoka; Hidehito Tochio; Hidekazu Hiroaki; Masahiro Shirakawa

  Journal of molecular biology, 26 May 2006, Peer-reviewed

  
• Heteronuclear multidimensional NMR and homology modelling studies of the C-terminal nucleotide-binding domain of the human mitochondrial ABC transporter ABCB6

  Kaori Kurashima-Ito; Teppei Ikeya; Hiroshi Senbongi; Hidehito Tochio; Tsutomu Mikawa; Takehiko Shibata; Yutaka Ito

  JOURNAL OF BIOMOLECULAR NMR, May 2006, Peer-reviewed

  
• A novel magnetic resonance-based method to measure gene expression in living cells

  S Ki; F Sugihara; K Kasahara; H Tochio; A Okada-Marubayashi; S Tomita; M Morita; M Ikeguchi; M Shirakawa; T Kokubo

  NUCLEIC ACIDS RESEARCH, 2006, Peer-reviewed

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• Structural characterization of the MIT domain from human Vps4b

  H Takasu; JG Jee; A Ohno; N Goda; K Fujiwara; H Tochio; M Shirakawa; H Hiroaki

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2005, Peer-reviewed

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• Molecular mechanism of a temperature-sensitive phenotype in peroxisomal biogenesis disorder

  K Hashimoto; Z Kato; T Nagase; N Shimozawa; K Kuwata; K Omoya; A Li; E Matsukuma; Y Yamamoto; H Ohnishi; H Tochio; M Shirakawa; Y Suzuki; RJA Wanders; N Kondo

  PEDIATRIC RESEARCH, Aug. 2005, Peer-reviewed

  
• Plc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in Saccharomyces cerevisiae

  C Auesukaree; H Tochio; M Shirakawa; Y Kaneko; S Harashima

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2005, Peer-reviewed

  
• Crystal structure of thymine DNA glycosylase conjugated to SUMO-1.

  Daichi Baba; Nobuo Maita; Jun-Goo Jee; Yasuhiro Uchimura; Hisato Saitoh; Kaoru Sugasawa; Fumio Hanaoka; Hidehito Tochio; Hidekazu Hiroaki; Masahiro Shirakawa

  Nature, 16 Jun. 2005, Peer-reviewed

  
• Structure of the UBA domain of Dsk2p in complex with ubiquitin: Molecular determinants for ubiquitin recognition

  A Ohno; J Jee; K Fujiwara; T Tenno; N Goda; H Tochio; H Kobayashi; H Hiroaki; M Shirakawa

  STRUCTURE, Apr. 2005, Peer-reviewed

  
• Structure of RNA aptamer complexed with an RNA-binding peptide of Tat with aid of residue-specific 13C, 15N labeling.

  Matsugami, A.; Tochio, H.; Niyada, E.; Tamura, Y.; Kudo, M.; Misono, T.S.; Kumar, P.; Katahira, M.

  Nucleic acids symposium series (2004), 2005, Peer-reviewed

  
• Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains (vol 9, pg 865, 2004)

  T Tenno; K Fujiwara; H Tochio; K Iwai; EH Morita; H Hayashi; S Murata; H Hiroaki; M Sato; K Tanaka; M Shirakawa

  GENES TO CELLS, Nov. 2004, Peer-reviewed

  
• Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains

  T Tenno; K Fujiwara; H Tochio; K Iwai; EH Morita; H Hayashi; S Murata; H Hiroaki; M Sato; K Tanaka; M Shirakawa

  GENES TO CELLS, Oct. 2004, Peer-reviewed

  
• Structural basis for distinct roles of Lys63- and Lys48-linked polyubiquitin chains

  T Tenno; K Fujiwara; H Tochio; K Iwai; EH Morita; H Hayashi; S Murata; H Hiroaki; M Sato; K Tanaka; M Shirakawa

  GENES TO CELLS, Oct. 2004, Peer-reviewed

  
• Structural biology of ubiquitin and ubiquitin binding domain/motif

  Kenichiro, F.; Hidehito, T.

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, May 2004, Peer-reviewed

  
• High-throughput construction method for expression vector of peptides for NMR study suited for isotopic labeling

  T Tenno; N Goda; Y Tateishi; H Tochio; M Mishima; H Hayashi; M Shirakawa; H Hiroaki

  PROTEIN ENGINEERING DESIGN & SELECTION, Apr. 2004, Peer-reviewed

  
• Intracellular phosphate serves as a signal for the regulation of the PHO pathway in Saccharomyces cerevisiae

  C Auesukaree; T Homma; H Tochio; M Shirakawa; Y Kaneko; S Harashima

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2004, Peer-reviewed

  
• Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B.

  Kenichiro Fujiwara; Takeshi Tenno; Kaoru Sugasawa; Jun-Goo Jee; Izuru Ohki; Chojiro Kojima; Hidehito Tochio; Hidekazu Hiroaki; Fumio Hanaoka; Masahiro Shirakawa

  The Journal of biological chemistry, 06 Feb. 2004, Peer-reviewed

  
• Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95

  JF Long; H Tochio; P Wang; JS Fan; C Sala; M Niethammer; M Sheng; MJ Zhang

  JOURNAL OF MOLECULAR BIOLOGY, Mar. 2003, Peer-reviewed

  
• Backbone dynamics of the 8 kDa dynein light chain dimer reveals molecular basis of the protein's functional diversity

  JS Fan; Q Zhang; H Tochio; MJ Zhang

  JOURNAL OF BIOMOLECULAR NMR, Jun. 2002, Peer-reviewed

  
• An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p

  H Tochio; MMK Tsui; DK Banfield; MJ Zhang

  SCIENCE, Jul. 2001, Peer-reviewed

  
• Structural basis of diverse sequence-dependent target recognition by the 8 kDa dynein light chain

  JS Fan; Q Zhang; H Tochio; M Li; MJ Zhang

  JOURNAL OF MOLECULAR BIOLOGY, Feb. 2001, Peer-reviewed

  
• Formation of nNOS/PSD-95 PDZ dimer requires a preformed beta-finger structure from the nNOS PDZ domain

  H Tochio; YK Mok; Q Zhang; HM Kan; DS Bredt; MJ Zhang

  JOURNAL OF MOLECULAR BIOLOGY, Oct. 2000, Peer-reviewed

  
• Formation of a native-like beta-hairpin finger structure of a peptide from the extended PDZ domain of neuronal nitric oxide synthase in aqueous solution

  P Wang; Q Zhang; H Tochio; JS Fan; MJ Zhang

  EUROPEAN JOURNAL OF BIOCHEMISTRY, Jun. 2000, Peer-reviewed

  
• Solution structure and backbone dynamics of the second PDZ domain of postsynaptic density-95

  H Tochio; F Hung; M Li; DS Bredt; MJ Zhang

  JOURNAL OF MOLECULAR BIOLOGY, Jan. 2000, Peer-reviewed

  
• Solution structure of the extended neuronal nitric oxide synthase PDZ domain complexed with an associated peptide

  H Tochio; Q Zhang; P Mandal; M Li; MJ Zhang

  NATURE STRUCTURAL BIOLOGY, May 1999, Peer-reviewed

  
• Intermolecular contacts between the lambda-Cro repressor and the operator DNA characterized by nuclear magnetic resonance spectroscopy

  H Tochio; C Kojima; H Matsuo; T Yamazaki; Y Kyogoku

  JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, Apr. 1999, Peer-reviewed

  
• Protein inhibitor of neuronal nitric-oxide synthase, PIN, binds to a 17-amino acid residue fragment of the enzyme

  JS Fan; QA Zhang; M Li; H Tochio; T Yamazaki; M Shimizu; MJ Zhang

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1998, Peer-reviewed

  
• Solution structure of a protein inhibitor of neuronal nitric oxide synthase

  H Tochio; S Ohki; Q Zhang; M Li; MJ Zhang

  NATURE STRUCTURAL BIOLOGY, Nov. 1998, Peer-reviewed

  
• Assignment of backbone resonances for larger proteins using the C-13-H-1 coherence of a H-1(alpha)-, H-2-, C-13-, and N-15-labeled sample

  T Yamazaki; H Tochio; J Furui; S Aimoto; Y Kyogoku

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 1997, Peer-reviewed

  
• CYTOKINE-INDUCING GLYCOLIPIDS IN THE LIPOTEICHOIC ACID FRACTION FROM ENTEROCOCCUS-HIRAE ATCC-9790

  Y SUDA; H TOCHIO; K KAWANO; H TAKADA; T YOSHIDA; S KOTANI; S KUSUMOTO

  FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, Oct. 1995, Peer-reviewed

  
• Induced structural changes in protein-DNA complexes

  Y Kyogoku; C Kojima; SJ Lee; H Tochio; N Suzuki; H Matsuo; M Shirakawa

  NUCLEAR MAGNETIC RESONANCE AND NUCLEIC ACIDS, 1995, Peer-reviewed

  

Misc.

• Structure study of UHRF1

  K, Arita; K. Sugita; M. Unoki; T. Oda; S. Isogai; H. Tochio; M. Sato; M. Ariyoshi; M. Shirakawa

  Acta Crystallographica Section A: Foundations and Advances, 2011

  
• NMRを用いた再構成ヌクレオソーム上におけるヒストン修飾認識機構解析

  西原宏直; 大木出; 大谷淳二; 水上進; 菊地和也; 杤尾豪人; 白川昌宏; 有吉眞理子

  生化学, 2010

  
• 核磁気共鳴法と再構成ヌクレオソームを用いたヒストン修飾認識機構の解明

  西原宏直; 大木出; 大谷淳二; 水上進; 菊地和也; 栃尾豪人; 白川昌宏; 有吉眞理子

  日本分子生物学会年会講演要旨集, 2009

  
• HR23Bユビキチン相同ドメイン-プロテアソームS5aサブユニットユビキチン結合モチーフ複合体の構造解析

  藤原健一朗; 天野剛志; 菅沢薫; JEE J-G; 大木出; 児嶋長次郎; 栃尾豪人; 広明秀一; 花岡文雄

  NMR討論会講演要旨集, 2003

  
• プロテアソームS5aサブユニットユビキチン結合モチーフとhHR23Bユビキチン相同ドメイン複合体の構造解析

  藤原健一朗; 天野剛志; 菅沢薫; JEE J G; 大木出; 児嶋長次郎; 栃尾豪人; 広明秀一; 花岡文雄

  日本分子生物学会年会プログラム・講演要旨集, 2003

  
• 直鎖型ユビキチンリガーゼLUBACの安定化機構の構造基盤研究

  徳永暉; 藤田宏明; WALINDA Erik; 大木出; 有吉眞理子; 杤尾豪人; 岩井一宏; 白川昌宏

  日本分子生物学会年会プログラム・要旨集(Web), 2018

  
• ダイヤモンドNV中心(NVC)による量子センシングによる細胞内の物性測定

  白川昌宏; 五十嵐龍治; 源城拓哉; 外間進悟; 藤咲貴大; 寺田大紀; 田辺竜太郎; 大木出; 吉成洋祐; 杤尾豪人

  日本分子生物学会年会プログラム・要旨集(Web), 2018

  
• 光検出磁気共鳴法による生細胞における1分子運動の計測

  白川昌宏; 五十嵐龍治; 五十嵐龍治; 源城拓哉; 外間進悟; 藤咲貴大; 寺田大紀; 田辺竜太郎; 大木出; 吉成洋祐; 杤尾豪人

  Abstracts. Annual Meeting of the NMR Society of Japan, 2017

  
• ダイアモンド粒子の窒素-空隙中心(NVC)を用いた生体・細胞のナノジャイロセンシング手法の開発

  白川昌宏; 五十嵐龍治; 久美屋雄太; 杉拓磨; 杉拓磨; 外間進悟; 杤尾豪人; 吉成洋祐; 原田慶恵

  日本蛋白質科学会年会プログラム・要旨集, 2015

  
• 蛍光性ナノダイヤモンドによる超解像イメージング及び角度計測に関する研究

  外間進悟; 五十嵐龍治; 杤尾豪人; 原田慶恵; 白川昌宏

  日本生化学会大会(Web), 2015

  
• ダイヤモンドスピンを用いた生体内ジャイロセンシング技術の開発

  久美屋雄太; 五十嵐龍治; 杉拓磨; 杉拓磨; 外間進悟; 杤尾豪人; 吉成洋祐; 原田慶恵; 白川昌宏; 白川昌宏

  Abstracts. Annual Meeting of the NMR Society of Japan, 2014

  
• 蛍光性ナノダイヤモンドを用いた一分子生体イメージング手法の開発

  飯村順; 外間進悟; 五十嵐龍治; 廣澤幸一郎; 藤原敬宏; 大西秀典; 水上進; 菊地和也; 杤尾豪人; 原田慶恵; 白川昌宏

  日本分子生物学会年会プログラム・要旨集(Web), 2014

  
• 基質/代謝物選択的NMRを応用した生体内代謝プロセスの直接追跡と薬剤活性のその場評価

  山田久嗣; 水澤圭吾; 五十嵐龍二; 杤尾豪人; 白川昌宏; 田畑泰彦; 木村祐; 近藤輝幸; 青山安宏; 山東信介

  日本化学会講演予稿集, 2012

  
• ナノダイアモンドを用いた光検出磁気共鳴顕微鏡装置の開発と生物試料への応用

  森重之; 吉成洋佑; 五十嵐龍治; 外間進悟; 横田浩章; 栃尾豪人; 白川昌宏; 原田慶恵; 原田慶恵; 池田和寛; 角谷均

  Abstracts. Annual Meeting of the NMR Society of Japan, 2012

  
• 生体内代謝プロセスの多重共鳴NMR追跡:多核多重ラベル化ウラシルの異化代謝反応

  山田久嗣; 水澤圭吾; 五十嵐龍二; 杤尾豪人; 白川昌宏; 田畑泰彦; 山東信介; 青山安宏

  日本化学会講演予稿集, 2011

  
• 多重共鳴NMR法による生体内代謝プロセスの直接追跡

  山田久嗣; 水澤圭吾; 五十嵐龍二; 杤尾豪人; 白川昌宏; 田畑泰彦; 木村祐; 近藤輝幸; 山東信介; 青山安宏

  JSMI Report, 2011

  
• 多重共鳴NMR法による生体内代謝プロセスの直接追跡

  山田久嗣; 水澤圭吾; 五十嵐龍二; 杤尾豪人; 白川昌宏; 田畑泰彦; 木村祐; 近藤輝幸; 山東信介; 青山安宏

  JSMI Report, 2011

  
• ¹³C,¹⁵Cラベル化基質を用いるコリン細胞取り込みの三重共鳴NMR解析

  篠田悠太; 青山安宏; 五十嵐龍治; 杤尾豪人; 白川昌宏

  日本化学会西日本大会講演要旨集, 2010

  
• Monitoring of Biological Process Using Multiple Resonance NMR: Turn-On Sensing of Metabolic Events with Signal Switching Probe

  水澤圭吾; 上平晃聖; 山東信介; 青山安宏; 五十嵐龍治; 栃尾豪人; 白川昌宏

  日本化学会講演予稿集, 2009

  
• 多重共鳴NMRを用いた生体における集積コリンおよびグルコース代謝物の選択的計測

  五十嵐龍治; 杤尾豪人; 水澤圭吾; 上平晃聖; 山東信介; 青山安宏; 白川昌宏

  Abstracts. Annual Meeting of the NMR Society of Japan, 2009

  
• In Vivo Chemistry:多重共鳴NMR技術を利用したOFF-ON型細胞・生体内化学解析

  堂浦智裕; 水澤圭吾; 五十嵐龍治; 栃尾豪人; 白川昌宏; 青山安宏; 山東信介

  日本化学会バイオテクノロジー部会シンポジウム講演要旨集, 2009

  
• 生体プロセスを追跡するための多重共鳴NMRの利用

  上平晃聖; 青山安宏; 五十嵐龍治; 栃尾豪人; 白川昌宏; 久家克明; 山内文生; 吉村公博; 矢野哲哉

  日本化学会講演予稿集, 2008

  
• 細胞システム解析に向けた分子プローブ:多重共鳴ラベル化プローブを用いた生体プロセスの追跡

  水澤圭吾; 上平晃聖; 山東信介; 青山安宏; 五十嵐龍治; 栃尾豪人; 白川昌宏; 久家克明; 山内文生; 吉村公博; 矢野哲哉

  日本化学会バイオテクノロジー部会シンポジウム講演要旨集, 2008

  
• 磁気共鳴法を用いたアフリカツメガエル卵母細胞内におけるタンパク質の立体構造情報の収集

  五十嵐龍治; 酒井智美; 原英之; 天野剛志; WAELCHLI Markus; 伊藤隆; 杤尾豪人; 白川昌宏

  Abstracts. Annual Meeting of the NMR Society of Japan, 2008

  
• 蛋白質立体構造からみたIL-18のシグナル伝達メカニズムの解明

  木村豪; 木村豪; 堤尚孝; 有田恭平; 有吉眞理子; 山本崇裕; 近藤直実; 近藤直実; 白川昌宏; 杤尾豪人; 加藤善一郎; 加藤善一郎

  呼吸, 2015

  
• NMR study of solution structure of lambda-Cro-DNA complex

  TOCHIO H.; KOJIMA C.; YAMAZAKI T.; KYOGOKU Y.

  Biophysics, Oct. 1997

  
• 免疫シグナルハブタンパク質MyD88の分子内相互作用解析

  宇野雅俊; 中山隆宏; 紺野宏記; 大西秀典; 白川昌宏; 杤尾豪人

  日本生化学会大会(Web), Dec. 2017

  
• NMR analysis of proteins in the cells

  Tochio Hidehito

  Chemistry, Jul. 2016

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• LUBACリガーゼ形成における相同性の高いHOIL-1L、SHARPINのUBLの機能的差異

  藤田 宏明; 清水 覚司; 徳永 暉; Walinda Erik; 高木 賢治; 水島 恒裕; 栃尾 豪人; 岩井 一宏

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• 安定同位元素を集積した高分子ナノプローブによるがんの分子標的MRイメージング

  山田久嗣; 長谷川嘉則; 木村祐; 今井宏彦; 松田哲也; 杤尾豪人; 白川昌宏; 山東信介; 青山安宏; 年光昭夫; 近藤輝幸; 宇都義浩

  第17回癌治療増感研究シンポジウム, Feb. 2015

  
• タンパク質NMRの生態系への応用：新規MRI及びin-cell NMR法

  李 真和; 榎園 能章; 猪股 晃介; 山田 久嗣; 今井 宏彦; 牧野 顕; 木村 俊作; 松田 哲也; 近藤 輝幸; 白川 昌宏; 杤尾 豪人

  第53回NMR討論会, Nov. 2014

  
• 第1章 構造解析のための先端技術の高度化 3.NMRを使った細胞内タンパク質の状態解析

  杤尾豪人

  実験医学, 10 Jun. 2014

  
• 安定同位元素を集積したポリマーナノプローブによるがんの分子標的MRイメージング

  山田 久嗣; 長谷川 嘉則; 鈴木 祐貴; 木村 祐; 今井 宏彦; 松田 哲也; 杤尾 豪人; 白川 昌宏; 山東 信介; 青山 安宏; 年光 昭夫; 近藤 輝幸

  日本分子イメージング学会第9回学術集会, May 2014

  
• 生化学に新たな視点を与える技術の開発とその応用 ナノダイヤモンドNVCを使った新しい生体・細胞計測法

  杤尾豪人; 外間進悟; 原田慶恵

  生化学, 25 Apr. 2014

  
• 安定同位元素ラベル化L-DOPAの合成と多重共鳴NMR法によるその代謝反応追跡

  亀田 哲郎; 山田 久嗣; 木村 祐; 今井 宏彦; 松田 哲也; 杤尾 豪人; 白川 昌宏; 山東 信介; 青山 安宏; 年光 昭夫; 近藤 輝幸

  日本化学会第94回春季年会, Mar. 2014

  
• HER2部分抗体を結合した新規キラルデンドリマーアミン配位Gd-MRI造影剤の合成と機能評価

  木村 祐; 沖塚 真珠美; 三宅 由花; 雉鳥 弘樹; 今井 宏彦; 松田 哲也; 杤尾 豪人; 白川 昌宏; 矢野 哲哉; 年光 昭夫; 近藤 輝幸

  日本化学会第94回春季年会, Mar. 2014

  
• アレルギー,自己免疫,自己炎症疾患治療薬開発に向けたIL‐18複合体の構造解析

  木村豪; 堤尚孝; 有田恭平; 有吉眞理子; 大西秀典; 白川昌宏; 近藤直実; 杤尾豪人; 加藤善一郎

  日本小児科学会雑誌, 01 Feb. 2014

  
• Application of nitrogen-vacancy centers of diamonds to biological Imaging

  Hidehito Tochio; Shingo Sotoma; Yoshie Harad

  Seikagaku, 2014

  
• 多重磁気共鳴イメージングのための安定同位元素集積化高分子プローブ

  長谷川 嘉則; 山田 久嗣; 木村 祐; 今井 宏彦; 松田 哲也; 杤尾 豪人; 白川 昌宏; 青山 安宏; 年光 昭夫; 近藤 輝幸

  第7回バイオ関連化学シンポジウム, Sep. 2013

  
• 分子標的MRイメージングのための新手法

  長谷川 嘉則; 山田 久嗣; 木村 祐; 今井 宏彦; 高山 裕生; 杉原 文徳; 松田 哲也; 杤尾 豪人; 白川 昌宏; 山東 信介; 青山 安宏; 年光 昭夫; 近藤 輝幸

  日本分子イメージング学会第8回学術集会, May 2013

  
• 安定同位元素ラベル化生体適合性高分子プローブの開発と磁気共鳴イメージングへの応用

  長谷川 嘉則; 山田 久嗣; 木村 祐; 杤尾 豪人; 白川 昌宏; 杉原 文徳; 今井 宏彦; 高山 裕生; 松田 哲也; 矢野 哲哉; 山東 信介; 青山 安宏; 年光 昭夫; 近藤 輝幸

  日本化学会第93回春季年会, Mar. 2013

  
• 高感度多重共鳴NMR解析のための安定同位元素ラベル化生体適合性高分子プローブ

  長谷川 嘉則; 山田 久嗣; 木村 祐; 杤尾 豪人; 白川 昌宏; 杉原 文徳; 今井 宏彦; 高山 裕生; 松田 哲也; 矢野 哲哉; 山東 信介; 青山 安宏; 年光 昭夫; 近藤 輝幸

  日本化学会第93回春季年会, Mar. 2013

  
• NMRで細胞内のタンパク質を見る

  杤尾豪人; 白川昌宏

  CSJ Curr Rev, 30 Nov. 2012

  
• 安定同位体元素を集積化した生体適合性高分子プローブの合成と多重共鳴NMR法による機能評価

  長谷川 嘉則; 山田 久嗣; 木村 祐; 杤尾 豪人; 白川 昌宏; 杉原 文徳; 今井 宏彦; 高山 裕生; 松田 哲也; 矢野 哲哉; 山東 信介; 青山 安宏; 年光 昭夫; 近藤 輝幸

  第2回CSJ化学フェスタ, Oct. 2012

  
• Triple resonance NMR in application to in situ monitoring of targeted metabolic reaction and its inhibition by a clinical drug

  Hisatsugu Yamada; Keigo Mizusawa; Ryuji Igarashi; Hidehito Tochio; Masahiro Shirakawa; Yasuhiko Tabata; Yu Kimura; Teruyuki Kondo; Yasuhiro Aoyama; Shinsuke Sando

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2012

  
• 磁気共鳴を使った真核細胞内タンパク質の構造・機能解析

  杤尾 豪人; 白川 昌宏

  YAKUGAKU ZASSHI, 2012, Peer-reviewed

  Access this misc :

  
• “多重共鳴NMR を応用した生体内代謝プロセスの直接追跡と薬剤活性のその場評価”

  山田久嗣; 水澤圭吾; 五十嵐龍二; 杤尾豪人; 白川昌宏; 田畑泰彦; 木村祐; 近藤輝幸; 青山安宏; 山東信介

  第5回バイオ関連化学シンポジウム,2011.9.26, 2011, Peer-reviewed

  
• 自然免疫異常症の構造生物学的解析

  大西秀典; 加藤善一郎; 木村豪; 久保田一生; 金子英雄; 近藤直実; 堤尚孝; 杤尾豪人; 白川昌宏

  日本小児科学会雑誌, 01 Dec. 2010

  
• In‐cell NMRによるヒト細胞内におけるタンパク質の構造・相互作用・フォールディング安定性の解析

  猪股晃介; 真板(大野)綾子; 杤尾豪人; 磯貝信; 天野剛志; 中瀬生彦; 武内敏秀; 二木史朗; 伊藤隆; 廣明秀一; 白川昌宏

  生化学, 25 Sep. 2009

  
• p62 UBAドメインのユビキチン認識機構の構造学的研究

  森本 大智; 磯貝 信; 阿部 翔吾; 有田 恭平; 雲財 悟; 天野 剛志; 有吉 眞理子; 杤尾 豪人; 小松 雅明; 田中 啓二; 白川 昌宏

  日本生化学会大会プログラム・講演要旨集, Sep. 2009

  
• タンパク質の構造を決める‐2 NMRによる生体高分子の解析手法の最近の進展 試験管から細胞内へ

  杤尾豪人; 猪股晃介; 白川昌宏

  化学と生物, 01 Sep. 2009

  
• 生命機能を解き明かす最新計測技術 In‐Cell NMRによる細胞内タンパク質のその場観察

  杤尾豪人; 白川昌宏

  Bio Ind, 12 Feb. 2009

  
• Structure of the UBA domain of Dsk2p in complex with ubiquitin: Molecular determinants for ubiquitin recognition.

  Ohno, A; Jee, J-G; Fujiwara, K; Tenno, T; Goda, N; Tochio, H; Kobayashi, H; Hiroaki, H; Shirakawa, M

  Structure, 2009

  
• In‐Cell NMRによる細胞内タンパク質の構造・機能の観察

  杤尾豪人; 白川昌宏

  遺伝子医学MOOK, 20 Feb. 2008

  
• Crystal structure of p62 ubiquitin associated (UBA) domain

  Shin Isogai; Takeshi Tenno; Morimoto Daichi; Abe Shogo; Tochio Hidehito; Arita Kyouhei; Ariyoshi Mariko; Tanaka Keiji; Shirakawa Masahiro

  ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2008

  
• SUMO化による転写調節因子heat shock factor2のDNA結合阻害の分子機構

  立石幸寛; 有吉眞理子; 五十嵐龍治; 水口賢司; 杤尾豪人; 白川昌宏

  生化学, 2008

  
• 新規亜鉛フィンガーモチーフCYRドメインの構造機能解析

  磯貝信; 有吉眞理子; 杤尾豪人; 菅野新一郎; 池上貴久; 伊藤隆; 安井明; 白川昌宏

  生化学, 2008

  
• 分子生物学的アプローチの臨床へのインパクトIL‐18及びシグナル伝達系タンパク質構造解析に基づく創薬へのアプローチ

  大西秀典; 加藤善一郎; 李愛蓮; 名田匡利; 相馬和佳; 松井永子; 金子英雄; 近藤直実; 杤尾豪人; 白川昌宏

  日本小児アレルギー学会誌, 20 Oct. 2007

  
• MyD88タンパク立体構造解析による新規シグナル伝達制御分子の開発

  大西秀典; 加藤善一郎; 李愛蓮; 名田匡利; 相馬和佳; 松井永子; 金子英雄; 近藤直実; 杤尾豪人; 白川昌宏

  アレルギー, 30 Sep. 2007

  
• 複製開始制御因子Sld2のリン酸化による機能制御の解析

  倉富博康; 池上貴久; 荒木弘之; 栃尾尚哉; 木川隆則; 横山茂之; 有吉眞理子; 杤尾豪人; 白川昌宏

  Abstr Annu Meet NMR Soc Jpn, 11 Sep. 2007

  
• 新規亜鉛フィンガーモチーフCYRドメインの構造機能解析

  磯貝信; 有吉眞理子; 杤尾豪人; 池上貴久; 伊藤隆; 菅野新一郎; 安井明; 白川昌宏

  Abstr Annu Meet NMR Soc Jpn, 11 Sep. 2007

  
• SUMO(Small Ubiquitin‐like Modifier)修飾によるタンパク質機能変換の構造生物学的研究

  杤尾豪人; 有田恭平; 関山直孝; 馬場大地; 斉藤寿仁; 池上貴久; 白川昌宏

  日本蛋白質科学会年会プログラム・要旨集, 07 May 2007

  
• Molecular basis of microtubule disassembly mechanism regulated by katanin p60

  Naoko Iwaya; Kouhei Akiyama; Satoru Unzai; Kentaro Tomii; Natsuko Goda; Takashi Nagata; Hidehito Tochio; Masahiro Shirakawa; Hidekazu Hiroaki

  International Workshop on Perspectives on Stable Isotope Aided NMR Methods for Protein Structural Analysis, Osaka, 30 Mar. 2007

  
• SUMO‐3(Small Ubiquitin‐like Modifier‐3)とSUMO‐interacting motif複合体の構造解析

  関山直孝; 斉藤寿仁; 池上貴久; 有吉眞理子; 杤尾豪人; 白川昌宏

  生化学, 2007

  
• SUMO‐3(Small Ubiquitin‐like Modifier‐3)とSBM(SUMO binding motif)複合体の構造解析

  関山直孝; 斉藤寿仁; 池上貴久; 杤尾豪人; 白川昌宏

  Abstr Annu Meet NMR Soc Jpn, 20 Nov. 2006

  
• Musashiタンパク質と標的RNAの複合体の構造解析

  大山貴子; 宮ノ入洋平; 永田崇; 栃尾豪人; 岡野栄之; 片平正人

  第8回日本RNA学会年会.淡路島, Jul. 2006

  
• 翻訳を抑制するタンパク質及びRNAに関する構造解析

  松上明正; 小泉大輔; 菊池邦夫; 楳原琢也; 西川冨美子; 西川諭; 大山貴子; 宮ノ入洋平; 永田崇; 栃尾豪人; 岡野栄之; 片平正人

  第8回日本RNA学会年会.淡路島, Jul. 2006

  
• 転写因子GT-1タンパク質のリン酸化によるDNA結合能上昇の構造学的基盤-リン酸化をミミックする変異型と天然型の構造比較-

  二矢田絵美; 能登和明; 宮ノ入洋平; 栃尾豪人; 永田崇; 平塚和之; 片平正人

  第6回日本蛋白質科学会年会.京都, Apr. 2006

  
• In Vivo Molecular Imaging by Using MRI

  SUGIHARA Fuminori; TOCHIO Hidehito

  Biophysics, 25 Nov. 2004

  
• Intracellular inorganic phosphate and polyphosphate are the signals of the PHO pathway in Saccharomyces cerevisiae.

  C Auesukaree; T Homma; H Tochio; M Shirakawa; Y Kaneko; S Harashima

  YEAST, Jul. 2003

  
• Structure of Photoactive Yellow Protein.

  塩沢久美子; 栃尾豪人; JEE J‐G; 池上貴久; 今元泰; 片岡幹雄; 白川昌宏

  NMR討論会講演要旨集, 01 Nov. 2001

  
• PDZヘテロニ量体の構造解析 (特集 ここまで進んだ構造生物学--立体構造解析から生命現象を解き明かす)

  杤尾 豪人; Mingjie Zhang

  細胞工学, Oct. 2001

  
• Solution structure and backbone dynamics of the second PDZ domain of postsynaptic density-95 (vol 295, pg 225, 2000)

  H Tochio; F Hung; M Li; DS Bredt; MJ Zhang

  JOURNAL OF MOLECULAR BIOLOGY, Mar. 2000

  

Industrial Property Rights

• 特開2015-067581, 特願2013-204511, 多重共鳴用のプローブ

  近藤 輝幸; 青山 安宏; 山田 久嗣; 亀田 哲郎; 木村 祐; 杤尾 豪人; 白川 昌宏; 年光 昭夫; 山東 信介

  
• 特許第5451041号, 特開2009-221187, 特願2008-306627, デンドリマー化合物、デンドリマー錯体及びMRI造影剤

  近藤 輝幸; 辻田 寛; ザイヌル; アベデン シデイキ; 松木 伸悟; 三浦 大樹; 杤尾 豪人; 松田 哲也; 楢崎 美智子; 都築 英寿; 久家 克明; 富田 佳紀; 吉村 公博; 矢野 哲哉

  
• 特開2014-001371, 特願2013-103159, 重合体、前記重合体を用いた核磁気共鳴分析用または磁気共鳴イメージング用の造影剤、化合物、前記重合体を用いた核磁気共鳴分析方法および磁気共鳴イメージング方法

  近藤 輝幸; 山田 久嗣; 長谷川 嘉則; 木村 祐; 青山 安宏; 杤尾 豪人; 白川 昌宏; 杉原 文徳; 松田 哲也; 山東 信介; 南 昌人; 山内 文生; 矢野 哲哉; 都築 英寿

  
• 特開2009-221187, 特願2008-306627, 化合物、その製造方法、金属錯体化合物、その製造方法及びMRI造影剤

  近藤 輝幸; 辻田 寛; ザイヌル; アベデン シデイキ; 松木 伸悟; 三浦 大樹; 杤尾 豪人; 松田 哲也; 楢崎 美智子; 都築 英寿; 久家 克明; 富田 佳紀; 吉村 公博; 矢野 哲哉

  
• WO2009-017255, JP2008064170, 変異導入MyD88蛋白によるToll様受容体/インターロイキン18シグナルの特異的制御法

  近藤 直実; 加藤 善一郎; 大西秀典; 白川 昌宏; 杤尾 豪人

  

External funds: Kakenhi

• Diamond NVC for protein analysis

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Hidehito Tochio

  From 01 Apr. 2016, To 31 Mar. 2017, Project Closed

  ダイアモンドNVC;ダイヤモンド;NVC;１分子計測;蛍光イメージング;磁気共鳴

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K14679/
• Structural biology of inflammatory response

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Hidehito Tochio

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  IL-18;MyD88;タンパク質;炎症;NMR;AFM;結晶構造解析;高速AFM;TIR;構造生物学;IL-37;X線結晶構造解析;蛋白質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H04752/
• 蛋白質ダイナミクスのin-cell NMR解析

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  杤尾 豪人

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  NMR;酸化還元電位;ジスルフィド結合;蛋白質;構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-15H01636/
• 直鎖型ポリユビキチン鎖合成の構造的基盤の解明

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  杤尾 豪人

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  直鎖型ユビキチン;X線結晶構造解析;蛋白質;ユビキチン;構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-15H01182/
• Development of analyzing methods for protein-protein interactions and protein dynamics by means of ODMR and in-cell NMR

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  Masahiro Shirakawa

  From 10 Jul. 2014, To 31 Mar. 2019, Project Closed

  ODMR;in-cell NMR;細胞内蛋白質;細胞小器官;Rheo-NMR;in cell NMR

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-26119004/
• 直鎖型ポリユビキチン鎖合成の構造的基盤の解明

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  杤尾 豪人

  From 01 Apr. 2013, To 31 Mar. 2015, Project Closed

  構造解析;ユビキチン;NMR;X線結晶構造解析;構造生物学;NF-κB

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-25112514/
• Structural probing of RNA molecules with in-cell NMR

  Grant-in-Aid for Scientific Research (B)

  Tokushima Bunri University;Tohoku University

  Yoshiyuki TANAKA

  From 01 Apr. 2012, To 31 Mar. 2016, Project Closed

  生体分子計測;NMR;安定同位体標識;バイオプローブ;細胞内化学反応

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24310163/
• Development of the multiresonance magnetic resonance imaging technique

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Hidehito TOCHIO

  From 01 Apr. 2011, To 31 Mar. 2012, Project Closed

  MRI;NMR;多重共鳴NMR

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659586/
• Spying minority in biological phenomena

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Osaka University;Tohoku University

  Akihiko ISHIJIMA

  From 01 Apr. 2011, To 31 Mar. 2016, Project Closed

  バクテリア;走化性;情報伝達;リン酸化;ダイヤモンドナノ粒子;ラマン分光

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23115004/
• Structural study of the Toll-like receptors signaling

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Hidehito TOCHIO

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  MyD88;IRAK;自然免疫;Toll 様受容体;NF-κB;IL-18;炎症;構造生物学;X線結晶構造解析;NMR;インフラマソーム;Toll様受容体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22370038/
• Analyses of the activation mechanisms of receptors of fatty acids and membrane receptors by in situ measurement

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  Masahiro SHIRAKAWA

  From 01 Apr. 2009, To 31 Mar. 2015, Project Closed

  NMR;脂質シャペロン;脂肪酸結合蛋白質;In-cell NMR;19F NMR;細胞生物学;FKBP12;FK506;ラパマイシン;立体構造;細胞計測;ESR;X線結晶法

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-21121006/
• Toll様受容体を介するシグナル伝達経路の構造機能解析

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  杤尾 豪人

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  自然免疫;Toll様受容体;NMR;構造生物学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18770092/
• Proteolysis in the Regulation of Biological Processes

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tokyo Medical and Dental University

  Noboru MIZUSHIMA

  From 01 Apr. 2006, To 31 Mar. 2012, Project Closed

  タンパク質分解;ユビキチン;オートファジー;カルパイン;プロテアーゼ;プロテオリシス;細胞内情報伝達;細胞構造・機能;構造生物学

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-18076008/
• Structural analysis of the intracellular proteolytic system

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  Hidehito TOCHIO;Hidehito TOHCIO

  From 01 Apr. 2006, To 31 Mar. 2011, Project Closed

  X線結晶構造解析;オートファジー;ユビキチン;NMR;中性子小角散乱;構造生物学;プロテアソーム;ユビキチン結合酵素;At16;溶液NMR;Xさ洙結晶構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-18076003/
• タンパク質タグの付加による細胞内タンパク質の局在・機能変換の構造学的研究

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University;Yokohama City University

  杤尾 豪人

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  ユビキチン;SUMO;構造生物学;タンパク質タグ;翻訳後修飾;NMR

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17028046/
• TLRシグナル伝達を決定するTIRドメイン間の相互作用の立体構造学的研究

  Grant-in-Aid for Young Scientists (B)

  Yokohama City University

  杤尾 豪人

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  自然免疫;NMR;構造生物学;Toll like receptor;MyD88;Toll様受容体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16770079/
• 磁気共鳴イメージング法を使った生体内遺伝子発現プロファイルのための新手法の開発

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Yokohama City University

  杤尾 豪人

  From 01 Apr. 2004, To 31 Mar. 2005, Project Closed

  遺伝子発現;MRI;レポーター遺伝子;ポリリン酸

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16011250/
• Structural study of signal transduction by membrane receptors through protein-protein interactions

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University;Yokohama City University

  Masahiro SHIRAKAWA

  From 01 Apr. 2003, To 31 Mar. 2009, Project Closed

  NMR;結晶構造解析;膜たんぱく質;免疫;膜受容体;立体構造;X線結晶構造解析法;インターロイキン;膜蛋白質;小胞輸送;SUMO;G蛋白質共役受容体;生理活性ペプチド;細胞内輸送;ペロキシソーム;ユビキチン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15083102/
• プロテアソームS5aサブユニットによるポリユビキチン鎖認識の立体構造学的研究

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Yokohama City University

  杤尾 豪人

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  蛋白質分解;ユビキチン;プロテアソーム;NMR;ユビキチン結合モチーフ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15032248/
• 磁気共鳴イメージング法を使った生体内遺伝子発現プロファイルのための新手法の開発

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Yokohama City University

  杤尾 豪人

  From 01 Apr. 2003, To 31 Mar. 2004, Project Closed

  MRI;イメージング;遺伝子発現プロファイル;レポーターアッセイ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15011247/
• 転写伸長を制御する因子の立体構造及びRNAポリメラーゼとの相互作用の解析

  Grant-in-Aid for Young Scientists (B)

  Yokohama City University

  杤尾 豪人

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  RNAポリメラーゼ;転写伸張;クロマチン;転写;転写伸長反応

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14780528/
• プロテオソームS5aサブユニットによるユビキチン様ドメイン認識の構造学的研究

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Yokohama City University

  杤尾 豪人

  From 01 Apr. 2002, To 31 Mar. 2003, Project Closed

  蛋白質;蛋白質分解;ユビキチン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14037261/
• 磁気共鳴イメージング法を使った生体内遺伝子発現プロファイルのための新手法の開発

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Yokohama City University

  杤尾 豪人

  From 01 Apr. 2002, To 31 Mar. 2003, Project Closed

  遺伝子;ゲノム;発現制御;細胞・組織

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14011243/
• Structural studies on the regulation of signal protein multimerization by receptors

  Grant-in-Aid for Scientific Research (B)

  Basic Section 43020:Structural biochemistry-related

  Kyoto University

  杤尾 豪人

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  自然免疫;多量化;MyD88;炎症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02421/
• Structural studies on the regulation of signal protein multimerization by receptors

  Grant-in-Aid for Scientific Research (B)

  Basic Section 43020:Structural biochemistry-related

  Kyoto University

  杤尾 豪人

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  MyD88;NMR;Ｘ線結晶構造解析;自然免疫;多量化;炎症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27114/

External funds: others

• 成熟B細胞リンパ腫の新規分子標的薬の開発 (2022年度分)

  京都市, 京都発革新的医療技術研究開発助成事業

  From 01 Apr. 2022, To 31 Mar. 2023

  研究代表者

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Biophysics

  N488, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Special Study CourseII(Biological Sciences) 15

  8718, Year-long, Faculty of Science, 12
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Structural Physiology IB

  9014, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Structural Physiology IA

  9013, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Structural Physiology IIA

  9017, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Structural Physiology ID

  9016, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Structural Physiology IC

  9015, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Structural Physiology IIB

  9018, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Structural Physiology IID

  9020, Fall, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Structural Physiology IIC

  9019, Spring, Graduate School of Science, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Course on Biological Science A

  9011, Spring, Graduate School of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Molecular Functions in Biological Systems

  9127, Spring, Graduate School of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Molecular Functions in Biological Systems

  3767, Spring, Faculty of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory work in Biological Science E

  3766, Fall, Faculty of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Biomolecular Science I

  2716, Spring, Faculty of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminars in Biological Science A

  4730, Fall, Faculty of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Biomolecular Science II

  2715, Fall, Faculty of Science, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Fundamental Experiments of Cellular and Molecular Biology

  2729, Fall, Faculty of Science, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Biophysics

  N488, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Special Study CourseII(Biological Sciences) 15

  8718, Year-long, Faculty of Science, 12
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Structural Physiology IID

  9020, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Structural Physiology IIC

  9019, Spring, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Structural Physiology IIB

  9018, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Structural Physiology IB

  9014, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Structural Physiology IA

  9013, Spring, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Structural Physiology IIA

  9017, Spring, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Structural Physiology ID

  9016, Fall, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Structural Physiology IC

  9015, Spring, Graduate School of Science, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Bio molecular Science

  2712, Spring, Faculty of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminars in Biological Science A

  4730, Fall, Faculty of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Molecular Functions in Biological Systems

  3767, Spring, Faculty of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory work in Biological Science E

  3766, Fall, Faculty of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Structural Biology

  8736, Fall, Faculty of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Molecular Functions in Biological Systems

  9127, Spring, Graduate School of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Biomolecular Science

  9118, Spring, Graduate School of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Course on Biological Science A

  9011, Spring, Graduate School of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Fundamental Experiments of Cellular and Molecular Biology

  2729, Fall, Faculty of Science, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminars in Biological Science A

  4730, Fall, Faculty of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Structural Biology

  8736, Fall, Faculty of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Biomolecular Science

  9118, Spring, Graduate School of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Structural Physiology ID

  9016, Fall, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Molecular Functions in Biological Systems

  9127, Spring, Graduate School of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Structural Physiology IC

  9015, Spring, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Structural Physiology IIA

  9017, Spring, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Structural Physiology IB

  9014, Fall, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Structural Physiology IA

  9013, Spring, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Bio molecular Science

  2712, Spring, Faculty of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Molecular Functions in Biological Systems

  3767, Spring, Faculty of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Fundamental Experiments of Cellular and Molecular Biology

  2729, Fall, Faculty of Science, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory work in Biological Science E

  3766, Fall, Faculty of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Biophysics

  N488, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Structural Physiology IIB

  9018, Fall, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Structural Physiology IIC

  9019, Spring, Graduate School of Science, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Course on Biological Science A

  9011, Spring, Graduate School of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Special Study CourseII(Biological Sciences) 15

  8718, Year-long, Faculty of Science, 12
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Structural Physiology IID

  9020, Fall, Graduate School of Science, 1
• From Apr. 2011, To Mar. 2012

  先端科学機器分析及び実習II

  Fall, 工学研究科
• From Apr. 2011, To Mar. 2012

  化学数学I（工業基礎化学）

  Fall, 工学部
• From Apr. 2011, To Mar. 2012

  物理化学III（工業基礎化学）［T15・T18］

  Fall, 工学部
• From Apr. 2011, To Mar. 2012

  物理化学III（工業基礎化学）［T16・T17］

  Fall, 工学部
• From Apr. 2012, To Mar. 2013

  Mathematical Method in Chemistry I (Fundamental Chemistry)

  Fall, 工学部
• From Apr. 2012, To Mar. 2013

  Physical Chemistry III (Fundamental Chemistry)

  Fall, 工学部
• From Apr. 2012, To Mar. 2013

  Biomolecular Function Chemistry

  Spring, 工学研究科
• From Apr. 2013, To Mar. 2014

  Mathematical Method in Chemistry I (Fundamental Chemistry)

  Fall, 工学部
• From Apr. 2013, To Mar. 2014

  Physical Chemistry III (Fundamental Chemistry)

  Fall, 工学部
• From Apr. 2014, To Mar. 2015

  Mathematical Method in Chemistry I (Fundamental Chemistry)

  Fall, 工学部
• From Apr. 2014, To Mar. 2015

  Physical Chemistry III (Fundamental Chemistry)

  Fall, 工学部
• From Apr. 2014, To Mar. 2015

  Biomolecular Function Chemistry

  Spring, 工学研究科
• From Apr. 2014, To Mar. 2015

  Structural Biology

  Fall, 理学部
• From Apr. 2014, To Mar. 2015

  Seminars in Biological Science A

  Fall, 理学部
• From Apr. 2015, To Mar. 2016

  Seminar on Structural Physiology IA

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Structural Physiology IB

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Structural Physiology IC

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Structural Physiology ID

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Structural Physiology IIA

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Structural Physiology IIB

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Structural Physiology IIC

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Seminar on Structural Physiology IID

  Fall, 理学研究科
• From Apr. 2015, To Mar. 2016

  Molecular Functions in Biological Systems

  Spring, 理学部
• From Apr. 2015, To Mar. 2016

  Molecular Functions in Biological Systems

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Biomolecular Science

  Spring, 理学研究科
• From Apr. 2015, To Mar. 2016

  Bio molecular Science

  Spring, 理学部
• From Apr. 2015, To Mar. 2016

  Biophysical Basis of Biological Phenomena

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Seminars in Biological Science A

  Fall, 理学部
• From Apr. 2015, To Mar. 2016

  Laboratory work in Biological Science B

  Spring, 理学部
• From Apr. 2015, To Mar. 2016

  Special Study CourseII(Biological Sciences) 15

  Year-long, 理学部
• From Apr. 2016, To Mar. 2017

  Structural Biology

  Fall, 理学部
• From Apr. 2016, To Mar. 2017

  Seminar on Structural Physiology IA

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Structural Physiology IB

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Structural Physiology IC

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Structural Physiology ID

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Structural Physiology IIA

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Structural Physiology IIB

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Structural Physiology IIC

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Seminar on Structural Physiology IID

  Fall, 理学研究科
• From Apr. 2016, To Mar. 2017

  Molecular Functions in Biological Systems

  Spring, 理学部
• From Apr. 2016, To Mar. 2017

  Molecular Functions in Biological Systems

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Biomolecular Science

  Spring, 理学研究科
• From Apr. 2016, To Mar. 2017

  Bio molecular Science

  Spring, 理学部
• From Apr. 2016, To Mar. 2017

  Seminars in Biological Science A

  Fall, 理学部
• From Apr. 2016, To Mar. 2017

  Laboratory work in Biological Science B

  Spring, 理学部
• From Apr. 2016, To Mar. 2017

  Introduction to Biophysics

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Special Study CourseII(Biological Sciences) 15

  Year-long, 理学部
• From Apr. 2017, To Mar. 2018

  Structural Biology

  Fall, 理学部
• From Apr. 2017, To Mar. 2018

  Seminar on Structural Physiology IA

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Structural Physiology IB

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Structural Physiology IC

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Structural Physiology ID

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Structural Physiology IIA

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Structural Physiology IIB

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Structural Physiology IIC

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Seminar on Structural Physiology IID

  Fall, 理学研究科
• From Apr. 2017, To Mar. 2018

  Molecular Functions in Biological Systems

  Spring, 理学部
• From Apr. 2017, To Mar. 2018

  Molecular Functions in Biological Systems

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Biomolecular Science

  Spring, 理学研究科
• From Apr. 2017, To Mar. 2018

  Bio molecular Science

  Spring, 理学部
• From Apr. 2017, To Mar. 2018

  Seminars in Biological Science A

  Fall, 理学部
• From Apr. 2017, To Mar. 2018

  Laboratory work in Biological Science B

  Spring, 理学部
• From Apr. 2017, To Mar. 2018

  Introduction to Biophysics

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Special Study CourseII(Biological Sciences) 15

  Year-long, 理学部
• From Apr. 2018, To Mar. 2019

  Experimental Course of Fundamental Biology III

  Fall, 理学部
• From Apr. 2018, To Mar. 2019

  Structural Biology

  Fall, 理学部
• From Apr. 2018, To Mar. 2019

  Seminar on Structural Physiology IA

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Structural Physiology IB

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Structural Physiology IC

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Structural Physiology ID

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Structural Physiology IIA

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Structural Physiology IIB

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Structural Physiology IIC

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Seminar on Structural Physiology IID

  Fall, 理学研究科
• From Apr. 2018, To Mar. 2019

  Molecular Functions in Biological Systems

  Spring, 理学部
• From Apr. 2018, To Mar. 2019

  Molecular Functions in Biological Systems

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Biomolecular Science

  Spring, 理学研究科
• From Apr. 2018, To Mar. 2019

  Bio molecular Science

  Spring, 理学部
• From Apr. 2018, To Mar. 2019

  Seminars in Biological Science A

  Fall, 理学部
• From Apr. 2018, To Mar. 2019

  Laboratory work in Biological Science B

  Spring, 理学部
• From Apr. 2018, To Mar. 2019

  Introduction to Biophysics

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Special Study CourseII(Biological Sciences) 15

  Year-long, 理学部
• From Apr. 2019, To Mar. 2020

  Experimental Course of Fundamental Biology III

  Fall, 理学部
• From Apr. 2019, To Mar. 2020

  Structural Biology

  Fall, 理学部
• From Apr. 2019, To Mar. 2020

  Seminar on Structural Physiology IA

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Structural Physiology IB

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Structural Physiology IC

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Structural Physiology ID

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Structural Physiology IIA

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Structural Physiology IIB

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Structural Physiology IIC

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Seminar on Structural Physiology IID

  Fall, 理学研究科
• From Apr. 2019, To Mar. 2020

  Molecular Functions in Biological Systems

  Spring, 理学部
• From Apr. 2019, To Mar. 2020

  Molecular Functions in Biological Systems

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Biomolecular Science

  Spring, 理学研究科
• From Apr. 2019, To Mar. 2020

  Bio molecular Science

  Spring, 理学部
• From Apr. 2019, To Mar. 2020

  Seminars in Biological Science A

  Fall, 理学部
• From Apr. 2019, To Mar. 2020

  Laboratory work in Biological Science B

  Spring, 理学部
• From Apr. 2019, To Mar. 2020

  Introduction to Biophysics

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Special Study CourseII(Biological Sciences) 15

  Year-long, 理学部
• From Apr. 2020, To Mar. 2021

  Structural Biology

  Fall, 理学部
• From Apr. 2020, To Mar. 2021

  Seminar on Structural Physiology IA

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Structural Physiology IB

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Structural Physiology IC

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Structural Physiology ID

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Structural Physiology IIA

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Structural Physiology IIB

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Structural Physiology IIC

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Structural Physiology IID

  Fall, 理学研究科
• From Apr. 2020, To Mar. 2021

  Molecular Functions in Biological Systems

  Spring, 理学部
• From Apr. 2020, To Mar. 2021

  Molecular Functions in Biological Systems

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Biomolecular Science

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Biomolecular Science

  Spring, 理学部
• From Apr. 2020, To Mar. 2021

  Seminars in Biological Science A

  Fall, 理学部
• From Apr. 2020, To Mar. 2021

  Laboratory Work in Biological Science B

  Spring, 理学部
• From Apr. 2020, To Mar. 2021

  Introduction to Biophysics

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Advanced Course on Biological Science A

  Spring, 理学研究科
• From Apr. 2020, To Mar. 2021

  Special Study CourseII(Biological Sciences) 15

  Year-long, 理学部
• From Apr. 2020, To Mar. 2021

  Fundamental Experiments of Cellular and Molecular Biology

  Fall, 理学部
• From Apr. 2021, To Mar. 2022

  Structural Biology

  Fall, 理学部
• From Apr. 2021, To Mar. 2022

  Seminar on Structural Physiology IA

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Structural Physiology IB

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Structural Physiology IC

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Structural Physiology ID

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Structural Physiology IIA

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Structural Physiology IIB

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Structural Physiology IIC

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Seminar on Structural Physiology IID

  Fall, 理学研究科
• From Apr. 2021, To Mar. 2022

  Molecular Functions in Biological Systems

  Spring, 理学部
• From Apr. 2021, To Mar. 2022

  Molecular Functions in Biological Systems

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Biomolecular Science

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Biomolecular Science

  Spring, 理学部
• From Apr. 2021, To Mar. 2022

  Seminars in Biological Science A

  Fall, 理学部
• From Apr. 2021, To Mar. 2022

  Laboratory Work in Biological Science B

  Spring, 理学部
• From Apr. 2021, To Mar. 2022

  Introduction to Biophysics

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Introduction to Biology and Life Science

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Advanced Course on Biological Science A

  Spring, 理学研究科
• From Apr. 2021, To Mar. 2022

  Special Study CourseII(Biological Sciences) 15

  Year-long, 理学部

Participation in PhD Defense

• 小胞体膜結合性転写因子ATF6αとATF6βがヌードマウスにおける癌細胞増殖に及ぼす影響の解析

  JIN SHENGYU, Graduate School of Science, Sub-chief Examiner

  23 May 2023
• メダカにおける飢餓誘導性脂肪肝発症ならびにレトロトランスロコン構成因子欠失による発症促進の分子機構解析

  IKEDA TOMOYO, Graduate School of Science, Sub-chief Examiner

  25 Mar. 2024
• Elucidation of RNA aptamer structure and interaction in living human cells through in-cell NMR spectroscopy

  OMAR SOBHI MOHAMED MAHMOUD ELADL, Graduate School of Energy Science, Sub-chief Examiner

  25 Mar. 2024
• Study of the recognition of G-quadruplex DNA by human ORC protein

  AFAF SOBHI MOHAMED MAHMOUD ELADL, Graduate School of Energy Science, Sub-chief Examiner

  23 Jan. 2023
• Analysis of conformational space sampled by domain reorientation in linear diubiquitin by paramagnetic NMR

  HOU, XUENI, Graduate School of Science, Chief Examiner

  24 Sep. 2021
• SEL1Lの分解中間体はポリグルタミンタンパク質の細胞質での凝集を促進する

  HATTORI TOKUYA, Graduate School of Science, Sub-chief Examiner

  24 Jan. 2022
• シロイヌナズナζクラスホスホリパーゼDの細胞生物学的研究

  SHIMAMURA RYOTA, Graduate School of Science, Sub-chief Examiner

  24 Jan. 2022

Administration

School management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2025

  国際高等教育院 企画評価専門委員会 生物学部会
• From 01 Apr. 2023, To 31 Mar. 2024

  国際高等教育院 企画評価専門委員会 初修外国語部会 委員
• From 01 Apr. 2022, To 31 Mar. 2023

  国際高等教育院 企画評価専門委員会 初修外国語部会 委員
• From 01 Apr. 2021, To 31 Mar. 2022

  国際高等教育院 企画評価専門委員会 初修外国語部会 委員

Faculty management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2025

  北部キャンパス機器分析拠点運営委員会委員
• From 01 Apr. 2024, To 31 Mar. 2025

  理学研究科低温物質科学研究支援室運営委員会委員
• From 01 Apr. 2024, To 31 Mar. 2025

  理学研究科低温物質科学研究支援室員
• From 01 Apr. 2024, To 31 Mar. 2025

  理学部・教育委員会委員
• From 01 Apr. 2024, To 31 Mar. 2025

  理学部・教育委員会　教務委員会委員
• From 01 Apr. 2024, To 31 Mar. 2025

  理学部・教育委員会　全学共通教育委員会委員
• From 01 Apr. 2023, To 31 Mar. 2024

  理学研究科将来計画委員会委員
• From 01 Apr. 2023, To 31 Mar. 2024

  理学研究科動物実験委員会委員
• From 01 Apr. 2023, To 31 Mar. 2024

  理学研究科低温物質科学研究支援室運営委員会委員
• From 01 Apr. 2023, To 31 Mar. 2024

  北部キャンパス機器分析拠点運営委員会委員
• From 01 Apr. 2023, To 31 Mar. 2024

  理学研究科研究科会議構成員
• From 01 Apr. 2023, To 31 Mar. 2024

  理学研究科専攻長会議構成員
• From 01 Apr. 2023, To 31 Mar. 2024

  理学研究科危機管理委員会委員
• From 01 Apr. 2022, To 31 Mar. 2023

  理学研究科自己点検・評価委員会委員
• From 01 Apr. 2022, To 31 Mar. 2023

  理学研究科SACRA広報・社会連携部門委員会委員
• From 01 Apr. 2022, To 31 Mar. 2023

  理学研究科SACRA広報・社会連携部門委員会　広報小委員会委員長
• From 01 Apr. 2022, To 31 Mar. 2023

  理学研究科低温物質科学研究支援室運営委員会委員
• From 01 Apr. 2022, To 31 Mar. 2023

  北部キャンパス機器分析拠点運営委員会委員
• From 01 Apr. 2020, To 31 Mar. 2020

  理学研究科生物科学専攻副専攻長
• From 01 Apr. 2015, To 31 Mar. 2017

  低温物質科学研究センター寒剤供給部管理運営委員会委員
• From 01 Apr. 2015, To 31 Mar. 2016

  理学研究科将来計画委員会委員
• From 01 Apr. 2015, To 31 Mar. 2016

  理学研究科国際・社会交流委員会委員
• From 01 Apr. 2015, To 31 Mar. 2016

  理学研究科国際・社会交流委員会　玉城記念小委員会委員長
• From 01 Apr. 2015, To 31 Mar. 2016

  理学研究科会議構成員
• From 01 Apr. 2016, To 31 Mar. 2017

  理学研究科生物科学専攻副専攻長
• From 01 Apr. 2016, To 31 Mar. 2017

  理学部・教育委員会委員
• From 01 Apr. 2016, To 31 Mar. 2017

  理学研究科動物実験委員会委員
• From 01 Apr. 2016, To 31 Mar. 2017

  理学研究科国際・社会交流委員会委員
• From 01 Apr. 2016, To 31 Mar. 2017

  理学研究科国際・社会交流委員会　国際交流奨学生推薦小委員会委員
• From 01 Apr. 2016, To 31 Mar. 2017

  理学研究科会議構成員
• From 01 Apr. 2017, To 31 Mar. 2018

  理学研究科自己点検評価委員会委員
• From 01 Apr. 2017, To 31 Mar. 2018

  理学部・教育委員会委員
• From 01 Apr. 2017, To 31 Mar. 2018

  理学部・教育委員会　少人数担任委員会委員
• From 01 Apr. 2017, To 31 Mar. 2018

  理学研究科大学院教育教務委員会委員
• From 01 Apr. 2017, To 31 Mar. 2018

  理学研究科広報委員会委員
• From 01 Apr. 2017, To 31 Mar. 2018

  理学研究科学術推進部低温物質科学研究支援室運営委員会委員
• From 01 Apr. 2016, To 31 Mar. 2018

  環境安全保健機構低温物質専門委員会委員
• From 01 Apr. 2016, To 31 Mar. 2020

  環境安全保健機構低温物質専門委員会委員
• From 01 Apr. 2018, To 31 Mar. 2019

  理学研究科将来計画委員会委員
• From 01 Apr. 2018, To 31 Mar. 2019

  理学部・教育委員会委員
• From 01 Apr. 2017, To 31 Mar. 2019

  理学部・教育委員会　少人数担任委員会委員
• From 01 Apr. 2018, To 31 Mar. 2019

  理学研究科低温物質科学研究支援室運営委員会委員
• From 01 Apr. 2018, To 31 Mar. 2019

  理学研究科研究科会議構成員
• From 01 Apr. 2019, To 31 Mar. 2020

  理学研究科将来計画委員会委員
• From 01 Apr. 2018, To 31 Mar. 2020

  理学研究科相談室運営委員会委員
• From 01 Apr. 2019, To 31 Mar. 2020

  理学研究科低温物質科学研究支援室運営委員会委員
• From 01 Apr. 2019, To 31 Mar. 2020

  理学研究科研究科会議構成員
• From 01 Apr. 2020, To 31 Mar. 2021

  理学研究科動物実験委員会委員
• From 01 Apr. 2020, To 31 Mar. 2021

  理学研究科低温物質科学研究支援室運営委員会委員
• From 01 Apr. 2020, To 31 Mar. 2021

  理学研究科研究科会議構成員
• From 01 Apr. 2020, To 31 Mar. 2021

  理学研究科専攻長会議構成員
• From 01 Apr. 2016, To 31 Mar. 2020

  環境安全保健機構低温物質専門委員会委員
• From 01 Jul. 2016, To 31 Mar. 2022

  環境安全保健機構低温物質管理部門寒剤供給専門小委員会
• From 01 Apr. 2021, To 31 Mar. 2022

  理学研究科大学院教育教務委員会委員
• From 01 Apr. 2021, To 31 Mar. 2023

  理学研究科サイエンス連携探索センター（SACRA)運営協議会委員
• From 01 Apr. 2021, To 31 Mar. 2022

  理学研究科SACRA広報・社会連携部門委員会委員
• From 01 Apr. 2021, To 31 Mar. 2022

  理学研究科SACRA広報・社会連携部門委員会　広報小委員会委員
• From 01 Apr. 2021, To 31 Mar. 2022

  理学研究科低温物質科学研究支援室運営委員会委員
• From 01 Apr. 2021, To 31 Mar. 2022

  北部キャンパス機器分析拠点運営委員会委員