Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医学専攻 神経再生研究, 教授
• Graduate School of Medicine, 医科学専攻 神経再生研究, 教授

Professional Memberships

• THE JAPAN NEUROSCIENCE SOCIETY
• THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE
• International Society for Stem Cell Reseach
• 日本脳神経外科コングレス
• 日本脳神経外科学会

Academic Degree

• 博士（医学）(京都大学)

Research History

• From 2022, To Present

  京都大学iPS細胞研究所, 所長
• From 2012, To Present

  京都大学iPS細胞研究所, 臨床応用研究部門, 教授
• From 2007, To 2012

  Kyoto University, Institute for Frontier Medical Sciences, 准教授
• From 2003, To 2007

  Kyoto University, Neurosurgery, Hospital, 講師
• From 1997, To 2003

  Kyoto University Hospital, Neurosurgery, 脳神経外科, 助手（復職）
• From 1995, To 1996

  米国ソーク研究所 ポスドク研究員
• From 1993, To 1994

  Kyoto University, Neurosurgery, Hospital, 助手

ID,URL

• J-Global ID

  201801012937289240

• External link

  https://www.cira.kyoto-u.ac.jp/j/research/takahashi_summary.html

researchmap URL

• https://researchmap.jp/20181003

Research

Research Topics, Overview of the research

• Research Topics

  neuronal regeneration using pluripotent stem cells

• Overview of the research

  We are developing a cell replacement therapy for the neurological disorders by using stem cells, especially embryonic stem cells (ES cells) and induced pluripotent stem cells (iPS cells). The main target is Parkinson's disease, and our research focuses on induction of dopaminergic (DA) neurons from these cells and transplantation of the cells into the brain to improve neurological symptoms. So far, we have demonstrated that transplantation of monkey ES cell-derived neurons improved the Parkinsonian symptoms of the monkey models. In addition, we have revealed a method to prevent tumor formation. Now, we are inducing DA neurons from human ES and iPS cells, and developing a safe and effective method for clinical application of these cells.

Research Interests

• 神経再生
• 脳神経外科

Research Areas

• Life sciences, Cell biology
• Life sciences, Neurosurgery

Papers

• Transplantation of mouse and primate es cells into ischemic mouse brain

  Yasushi Takagi; Motoaki Fujimoto; Makoto Hayase; Junya Hayashi; Jun Takahashi; Nobuo Hashimoto; Kazuhiko Nozaki

  Journal of Cerebral Blood Flow and Metabolism, 13 Nov. 2007

  
• Cell transplantation therapy using induced pluripotent stem cell-derived dopaminergic progenitors for parkinson’s disease

  Daisuke Doi; Jun Takahashi

  Drug Delivery System, 2020

  
• Contribution of the Pulvinar and Lateral Geniculate Nucleus to the Control of Visually Guided Saccades in Blindsight Monkeys.

  Norihiro Takakuwa; Kaoru Isa; Hirotaka Onoe; Jun Takahashi; Tadashi Isa

  The Journal of neuroscience : the official journal of the Society for Neuroscience, 24 Feb. 2021, Peer-reviewed

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• High Mobility Group A1 Regulates Transcription Levels of Oligodendrocyte Marker Genes in Cultured Oligodendrocyte Precursor Cells

  Egawa N; Hamanaka G; K Chung; Ishikawa H; Shindo A; Maki T; Takahashi R; Inoue H; Eng H. Lo; Arai K

  International Journal of Molecular Sciences, 17 Feb. 2022, Peer-reviewed

  
• iPSC-based drug repositioning identifies Src/c-Abl as a therapeutic target for ALS motor neurons.

  Imamura K; Izumi Y; Watanabe A; Tsukita K; Woltjen K; Yamamoto T; Hotta A; Kondo T; Kitaoka S; Ohta A; Tanaka A; Watanabe D; Morita M; Kaji R; Takuma H; Tamaoka A; Kunath T; Wray S; Furuya H; Era T; Fujisawa T; Nishotoh H; Kengo H; Ichijo H; Julien J-P; Obata N; Hosokawa M; Akiyama H; Ayaki T; Ito H; Takahashi R; Yamanaka S; Inoue H

  Science Translational Medicine, May 2017, Peer-reviewed

  
• CHEMOTHERAPY AND WHOLE-VENTRICULAR IRRADIATION WITH INTENSITY-MODULATED RADIATION THERAPY FOR INTRACRANIAL GERMINOMAS

  Kenichiro Watanabe; Hisanori Fujino; Matsubara Hiroshi; Adachi Souichi; Tatsutoshi Nakahata; Kishi Yo; Yoshiki Arakawa; Jun Takahashi; Takashi Mizowaki

  PEDIATRIC BLOOD & CANCER, Nov. 2009, Peer-reviewed

  
• Treatment Results and Surgical Complications of Asymptomatic Non-ruptured Intracranial Aneurysms.

  MANAKA Hiroshi; SAKAI Nobuyuki; NAGATA Izumi; NAKAHARA Ichiro; SHIMOZURU Tetsurou; SAKAI Hideki; HIGASHI Toshio; TAKAHASHI Jun C.; OHTA Hajime; KOKUZAWA Jouji; MORIZANE Asuka; ANEI Ryougo; SHINDO Atsushi; KAWABATA Yasuhiro; KIKUCHI Haruhiko

  Nosotchu no Geka Kenkyukai koenshu, 2001

  
• Brain Attack最前線 直達手術か血管内手術か(2) 急性期破裂脳動脈瘤塞栓術の治療成績

  坂井 信幸; 滝 和郎; 中原 一郎; 村尾 健一; 下鶴 哲郎; 酒井 秀樹; 東 登志夫; 高橋 淳; 大田 元; 石澤 錠二; 間中 浩; 森実 飛鳥; 川端 康弘; 永田 泉; 菊池 晴彦

  The Mt. Fuji Workshop on CVD, Jul. 2000, Peer-reviewed

  
• 研修医のためのクリニカルカンファレンス 頸動脈病変のステント留置における超音波診断の意義

  石澤 錠二; 中原 一郎; 坂井 信幸; 下鶴 哲郎; 酒井 秀樹; 東 登志夫; 高橋 淳; 大田 元; 間中 浩; 森実 飛鳥; 新堂 敦; 川端 康弘; 永田 泉; 山上 宏; 菊池 晴彦

  脳神経外科速報, Dec. 1999, Peer-reviewed

  
• 頚部頚動脈狭窄病変に対する外科治療のトピックス ＣＥＡとＳｔｅｎｔｉｎｇの選択:CEAとStentingの選択

  秋山 義典; 坂井 信幸; 中原 一郎; 酒井 秀樹; 石澤 錠二; 間中 浩; 森実 飛鳥; 林 直樹; 高橋 淳; 永田 泉

  脳卒中, 1999

  
• Viral delivery of L1CAM promotes axonal extensions by embryonic cerebral grafts in mouse brain.

  Ryosuke Tsuchimochi; Keitaro Yamagami; Naoko Kubo; Naoya Amimoto; Fabian Raudzus; Bumpei Samata; Tetsuhiro Kikuchi; Daisuke Doi; Koji Yoshimoto; Aya Mihara; Jun Takahashi

  Stem cell reports, 11 Apr. 2023

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• Induction of the Germ-Cell Fate from Pluripotent Stem Cells in Cynomolgus Monkeys.

  Sakai Y; Nakamura T; Okamoto I; Gyobu-Motani S; Ohta H; Yabuta Y; Tsukiyama T; Iwatani C; Tsuchiya H; Ema M; Morizane A; Takahashi J; Yamamoto T; Saitou M

  Biology of reproduction, Nov. 2019, Peer-reviewed

  
• Automated measurement of fluorescence signals reveals a significant increase of the graft-derived neurite extension in neonates compared to aged rats

  Luc Grinand; Jun Takahashi

  Regenerative Therapy, Mar. 2022, Peer-reviewed

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• Cryopreservation of Induced Pluripotent Stem Cell-Derived Dopaminergic Neurospheres for Clinical Application

  Satoe Hiramatsu; Asuka Morizane; Tetsuhiro Kikuchi; Daisuke Doi; Kenji Yoshida; Jun Takahashi

  Journal of Parkinson's Disease, 24 Dec. 2021, Peer-reviewed

  
• Long-term seizure outcome following resective surgery for epilepsy: To be or not to be completely cured?

  Takeharu Kunieda; Nobuhiro Mikuni; Sumiya Shibata; Rika Inano; Yukihiro Yamao; Takayuki Kikuchi; Riki Matsumoto; Jun Takahashi; Akio Ikeda; Hidenao Fukuyama; Susumu Miyamoto

  Neurologia Medico-Chirurgica, 2013, Peer-reviewed

  
• Electric stimulation on human cortex suppresses fast cortical activity and epileptic spikes

  Masako Kinoshita; Akio Ikeda; Riki Matsumoto; Tahamina Begum; Keiko Usui; Junichi Yamamoto; Masao Matsuhashi; Motohiro Takayama; Nobuhiro Mikuni; Jun Takahashi; Susumu Miyamoto; Hiroshi Shibasaki

  Epilepsia, Jul. 2004, Peer-reviewed

  
• Multisensory convergence at human temporo-parietal junction - Epicortical recording of evoked responses

  Masao Matsuhashi; Akio Ikeda; Shinji Ohara; Riki Matsumoto; Junichi Yamamoto; Motohiro Takayama; Takeshi Satow; Tahamina Begum; Keiko Usui; Takashi Nagamine; Nobuhiro Mikuni; Jun Takahashi; Susumu Miyamoto; Hidenao Fukuyama; Hiroshi Shibasaki

  Clinical Neurophysiology, May 2004, Peer-reviewed

  
• "Supplementary motor area (SMA) seizure" rather than "SMA epilepsy" in optimal surgical candidates: A document of subdural mapping

  Akio Ikeda; Takeshi Sato; Shinji Ohara; Masao Matsuhashi; Junichi Yamamoto; Motohiro Takayama; Riki Matsumoto; Nobuhiro Mikuni; Jun Takahashi; Susumu Miyamoto; Waro Taki; Nobuo Hashimoto; Hiroshi Shibasaki

  Journal of the Neurological Sciences, 15 Oct. 2002, Peer-reviewed

  
• Low-frequency electric cortical stimulation has an inhibitory effect on epileptic focus in mesial temporal lobe epilepsy

  Junichi Yamamoto; Akio Ikeda; Takeshi Satow; Kazuhide Takeshita; Motohiro Takayama; Masao Matsuhashi; Riki Matsumoto; Shinji Ohara; Nobuhiro Mikuni; Jun Takahashi; Susumu Miyamoto; Waro Taki; Nobuo Hashimoto; John C. Rothwell; Hiroshi Shibasaki

  Epilepsia, 2002, Peer-reviewed

  
• Pretreatment with Perlecan-Conjugated Laminin-E8 Fragment Enhances Maturation of Grafted Dopaminergic Progenitors in Parkinson’s Disease Model

  Hiromasa Adachi; Asuka Morizane; Sadaharu Torikoshi; Fabian Raudzus; Yukimasa Taniguchi; Susumu Miyamoto; Kiyotoshi Sekiguchi; Jun Takahashi

  Stem Cells Translational Medicine, 20 Jul. 2022, Peer-reviewed

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• Microsurgical Anatomy and Surgical Procedures for the Tentorial Incisura

  TAKAHASHI Jun C.; MIYAMOTO Susumu

  Jpn J Neurosurg, 20 Sep. 2012

  
• The effect of vascular progenitor cells on chronic cerebral hypoperfusion mouse model

  Kazuo Washida; Masafumi Ihara; Jun Takahashi; Hidefumi Ito; Hidekazu Tomimoto; Ryosuke Takahashi

  NEUROSCIENCE RESEARCH, 2009, Peer-reviewed

  
• Evading the Immune System: Immune Modulation and Immune Matching in Cell Replacement Therapies for Parkinson’s Disease

  Asuka Morizane; Jun Takahashi

  Journal of Parkinson's Disease, 22 Sep. 2021

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• Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level

  Xinyue Yuan; Manuel Schröter; Marie Engelene J. Obien; Michele Fiscella; Wei Gong; Tetsuhiro Kikuchi; Aoi Odawara; Shuhei Noji; Ikuro Suzuki; Jun Takahashi; Andreas Hierlemann; Urs Frey

  Nature Communications, Dec. 2020

  
• Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation.

  A Nakano-Kobayashi; A Fukumoto; A Morizane; D T Nguyen; T M Le; K Hashida; T Hosoya; R Takahashi; J Takahashi; O Hori; M Hagiwara

  Science advances, Nov. 2020

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• 小児出血型もやもや病に対する直接血行再建

  舟木 健史; 高橋 淳; 宮本 享

  小児の脳神経, Nov. 2020

  
• 【頭蓋内血管狭窄病変】もやもや病に対する脳血行再建術のエビデンス

  舟木 健史; 高橋 淳; 宮本 享

  脳神経外科ジャーナル, Oct. 2020

  
• Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson's disease.

  Daisuke Doi; Hiroaki Magotani; Tetsuhiro Kikuchi; Megumi Ikeda; Satoe Hiramatsu; Kenji Yoshida; Naoki Amano; Masaki Nomura; Masafumi Umekage; Asuka Morizane; Jun Takahashi

  Nature communications, 06 Jul. 2020, Peer-reviewed

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• Axonal Extensions along Corticospinal Tracts from Transplanted Human Cerebral Organoids

  Takahiro Kitahara; Hideya Sakaguchi; Asuka Morizane; Tetsuhiro Kikuchi; Susumu Miyamoto; Jun Takahashi

  Stem Cell Reports, Jul. 2020, Peer-reviewed

  
• Zonisamide promotes survival of human‐induced pluripotent stem cell‐derived dopaminergic neurons in the striatum of female rats

  Yoshifumi Miyawaki; Bumpei Samata; Tetsuhiro Kikuchi; Kaneyasu Nishimura; Jun Takahashi

  Journal of Neuroscience Research, 07 Jun. 2020, Peer-reviewed

  
• Exercise Promotes Neurite Extensions from Grafted Dopaminergic Neurons in the Direction of the Dorsolateral Striatum in Parkinson’s Disease Model Rats

  Sadaharu Torikoshi; Asuka Morizane; Takafumi Shimogawa; Bumpei Samata; Susumu Miyamoto; Jun Takahashi

  Journal of Parkinson's Disease, 03 Apr. 2020, Peer-reviewed

  
• L1CAM Is a Marker for Enriching Corticospinal Motor Neurons in the Developing Brain

  Bumpei Samata; Rika Takaichi; Yuko Ishii; Kaori Fukushima; Harumi Nakagawa; Yuichi Ono; Jun Takahashi

  Frontiers in Cellular Neuroscience, 19 Feb. 2020, Peer-reviewed

  
• Preclinical evaluation of patient-derived cells shows promise for Parkinson’s disease

  Jun Takahashi

  Journal of Clinical Investigation, 13 Jan. 2020, Invited

  
• Evidence and Future Prospects of Cerebral Revascularization for Moyamoya Disease

  Funaki Takeshi; C. Takahashi Jun; Miyamoto Susumu

  Japanese Journal of Neurosurgery, 2020

  
• Induced pluripotent stem cell technology: venturing into the second decade

  Yanhong Shi; Haruhisa Inoue; Jun Takahashi; Shinya Yamanaka

  Principles of Tissue Engineering, 2020

  
• Hypothalamic Contribution to Pituitary Functions Is Recapitulated In Vitro Using 3D-Cultured Human iPS Cells

  Takatoshi Kasai; Hidetaka Suga; Mayu Sakakibara; Chikafumi Ozone; Ryusaku Matsumoto; Mayuko Kano; Kazuki Mitsumoto; Koichiro Ogawa; Yu Kodani; Hiroshi Nagasaki; Naoko Inoshita; Mariko Sugiyama; Takeshi Onoue; Taku Tsunekawa; Yoshihiro Ito; Hiroshi Takagi; Daisuke Hagiwara; Shintaro Iwama; Motomitsu Goto; Ryoichi Banno; Jun Takahashi; Hiroshi Arima

  Cell Reports, Jan. 2020, Peer-reviewed

  
• The Ethics of Cerebral Organoid Research: Being Conscious of Consciousness

  Tsutomu Sawai; Hideya Sakaguchi; Elizabeth Thomas; Jun Takahashi; Misao Fujita

  Stem Cell Reports, Sep. 2019, Peer-reviewed

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• Self-Organized Synchronous Calcium Transients in a Cultured Human Neural Network Derived from Cerebral Organoids

  Hideya Sakaguchi; Yuki Ozaki; Tomoka Ashida; Takayoshi Matsubara; Naotaka Oishi; Shunsuke Kihara; Jun Takahashi

  Stem Cell Reports, Sep. 2019, Peer-reviewed

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• 小児もやもや病の手術法と長期成績 小児もやもや病における成人後出血転化例の脳血管撮影の特徴

  舟木 健史; 高橋 淳; 宮本 享

  小児の脳神経, Apr. 2019, Peer-reviewed

  
• 小児もやもや病に対する前・後大脳動脈領域への直接血行再建 周術期および中期治療成績の検証

  舟木 健史; 高橋 淳; 宮本 享

  小児の脳神経, Mar. 2019, Peer-reviewed

  
• 【出血性脳血管障害】出血型もやもや病治療の新たな展開

  舟木 健史; 高橋 淳; 宮本 享; JAM Trial Group

  脳神経外科ジャーナル, Mar. 2019, Peer-reviewed

  
• MicroRNA-Based Separation of Cortico-Fugal Projection Neuron-Like Cells Derived From Embryonic Stem Cells.

  Tadashi Sunohara; Asuka Morizane; Satoshi Matsuura; Susumu Miyamoto; Hirohide Saito; Jun Takahashi

  Frontiers in neuroscience, 2019, Peer-reviewed

  
• Therapeutic effects of combined cell transplantation and locomotor training in rats with brain injury.

  Takafumi Shimogawa; Hideya Sakaguchi; Tetsuhiro Kikuchi; Ryosuke Tsuchimochi; Noritaka Sano; Sadaharu Torikoshi; Akira Ito; Tomoki Aoyama; Koji Iihara; Jun Takahashi

  NPJ Regenerative medicine, 2019, Peer-reviewed

  
• Xeno-free culture for generation of forebrain oligodendrocyte precursor cells from human pluripotent stem cells

  Yulius Hermanto; Takakuni Maki; Yasushi Takagi; Susumu Miyamoto; Jun Takahashi

  J Neurosci Res, 2019, Peer-reviewed

  
• erification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model

  Jose Ichisima; Naoya M Suzuki; Bumpei Samata; Tomonari Awaya; Jun Takahashi; Masatoshi Hagiwara; Tatsutoshi Nakahata; Megumu K Saito

  J Hum Genet, 2019, Peer-reviewed

  
• 小児もやもや病診断・治療の進歩と長期予後 小児もやもや病の成人後の遅発性脳血管イベントおよび社会的予後

  舟木 健史; 高橋 淳; 宮本 享

  The Mt. Fuji Workshop on CVD, Jul. 2018, Peer-reviewed

  
• Three-dimensional induction of dorsal, intermediate and ventral spinal cord tissues from human pluripotent stem cells.

  Ogura T; Sakaguchi H; Miyamoto S; Takahashi J

  Development, Jul. 2018, Peer-reviewed

  
• Transplantation of feeder-free human induced pluripotent stem cell–derived cortical neuron progenitors in adult male Wistar rats with focal brain ischemia

  Yulius Hermanto; Tadashi Sunohara; Ahmad Faried; Yasushi Takagi; Jun Takahashi; Takakuni Maki; Susumu Miyamoto

  Journal of Neuroscience Research, 01 May 2018, Peer-reviewed

  
• 小児出血発症もやもや病に対する直接血行再建

  舟木 健史; 高橋 淳; 宮本 享

  小児の脳神経, Apr. 2018, Peer-reviewed

  
• Stem cells and regenerative medicine for neural

  Takahashi J

  Curr Opin Biotechnol, Apr. 2018, Peer-reviewed

  
• Human Trials of Stem Cell-Derived Dopamine Neurons for Parkinson's Disease: Dawn of a New Era

  Roger A. Barker; Malin Parmar; Lorenz Studer; Jun Takahashi

  Cell Stem Cell, 02 Nov. 2017, Peer-reviewed

  
• もやもや病を究める もやもや病の手術成績 中長期予後へのインパクト

  高橋 淳; 濱野 栄佳; 片岡 大治; 舟木 健史; 宮本 享

  脳循環代謝, Nov. 2017, Peer-reviewed

  
• Idiopathic Parkinson's Disease Patient-derived Induced Pluripotent Stem Cells Function as Midbrain Dopaminergic Neurons in Rodent Brains

  Tetsuhiro Kikuchi; Asuka Morizane; Daisuke Doi; Keisuke Okita; Masato Nakagawa; Hodaka Yamakado; Haruhisa Inoue; Ryosuke Takahashi; Jun Takahashi

  JOURNAL OF NEUROSCIENCE RESEARCH, Sep. 2017, Peer-reviewed

  
• MHC matching improves engraftment of iPSC-derived neurons in non-human primates

  Asuka Morizane; Tetsuhiro Kikuchi; Takuya Hayashi; Hiroshi Mizuma; Sayuki Takara; Hisashi Doi; Aya Mawatari; Matthew F. Glasser; Takashi Shiina; Hirohito Ishigaki; Yasushi Itoh; Keisuke Okita; Emi Yamasaki; Daisuke Doi; Hirotaka Onoe; Kazumasa Ogasawara; Shinya Yamanaka; Jun Takahashi

  NATURE COMMUNICATIONS, Aug. 2017, Peer-reviewed

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• Human iPS cell-derived dopaminergic neurons function in a primate Parkinson's disease model

  Tetsuhiro Kikuchi; Asuka Morizane; Daisuke Doi; Hiroaki Magotani; Hirotaka Onoe; Takuya Hayashi; Hiroshi Mizuma; Sayuki Takara; Ryosuke Takahashi; Haruhisa Inoue; Satoshi Morita; Michio Yamamoto; Keisuke Okita; Masato Nakagawa; Malin Parmar; Jun Takahashi

  NATURE, Aug. 2017, Peer-reviewed

  
• Enhanced Axonal Extension of Subcortical Projection Neurons Isolated from Murine Embryonic Cortex using Neuropilin-1

  Noritaka Sano; Takafumi Shimogawa; Hideya Sakaguchi; Yoshihiko Ioroi; Yoshifumi Miyawaki; Asuka Morizane; Susumu Miyamoto; Jun Takahashi

  FRONTIERS IN CELLULAR NEUROSCIENCE, May 2017, Peer-reviewed

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• 小児もやもや病の手術法 小児もやもや病に対する直接血行再建 特に前・後大脳動脈領域への直接血行再建手技について

  舟木 健史; 高橋 淳; 宮本 享

  小児の脳神経, Apr. 2017, Peer-reviewed

  
• 【State of the Art-難治例に対する手術-】出血発症もやもや病に対する外科治療のエビデンスと最新の知見

  舟木 健史; 高橋 淳; 宮本 享

  脳神経外科ジャーナル, Jan. 2017, Peer-reviewed

  
• Strategies for bringing stem cell-derived dopamine neurons to the clinic: The Kyoto trial

  Jun Takahashi

  FUNCTIONAL NEURAL TRANSPLANTATION IV: TRANSLATION TO CLINICAL APPLICATION, PT A, 2017, Peer-reviewed

  
• Genetic and pharmacological correction of aberrant dopamine synthesis using patient iPSCs with BH4 metabolism disorders

  Taizo Ishikawa; Keiko Imamura; Takayuki Kondo; Yasushi Koshiba; Satoshi Hara; Hiroshi Ichinose; Mahoko Furujo; Masako Kinoshita; Tomoko Oeda; Jun Takahashi; Ryosuke Takahashi; Haruhisa Inoue

  HUMAN MOLECULAR GENETICS, Dec. 2016, Peer-reviewed

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• 【脳卒中治療-Consensus、Controversy、New Trials】Consensus 出血発症もやもや病に対するバイパス治療

  舟木 健史; 高橋 淳; 宮本 享

  Clinical Neuroscience, Nov. 2016, Peer-reviewed

  
• Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1

  Bumpei Samata; Daisuke Doi; Kaneyasu Nishimura; Tetsuhiro Kikuchi; Akira Watanabe; Yoshimasa Sakamoto; Jungo Kakuta; Yuichi Ono; Jun Takahashi

  NATURE COMMUNICATIONS, Oct. 2016, Peer-reviewed

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• Cytoplasmic aggregates of dynactin in iPSC-derived tyrosine hydroxylase-positive neurons from a patient with Perry syndrome

  Takayasu Mishima; Taizo Ishikawa; Keiko Imamura; Takayuki Kondo; Yasushi Koshiba; Ryosuke Takahashi; Jun Takahashi; Akihiro Watanabe; Naoki Fujii; Yoshio Tsuboi; Haruhisa Inoue

  PARKINSONISM & RELATED DISORDERS, Sep. 2016, Peer-reviewed

  
• MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells

  Callum J. C. Parr; Shota Katayama; Kenji Miki; Yi Kuang; Yoshinori Yoshida; Asuka Morizane; Jun Takahashi; Shinya Yamanaka; Hirohide Saito

  SCIENTIFIC REPORTS, Sep. 2016, Peer-reviewed

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• Drug discovery toward successful cell transplantation therapy for Parkinson's disease using human pluripotent stem cells.

  Nishimura K; Takahashi J

  Adv Regen Biol., Aug. 2016, Peer-reviewed

  
• JAM Trial 結果と今後の展望

  舟木 健史; 高橋 淳; 宮本 享

  脳卒中の外科, Jul. 2016, Peer-reviewed

  
• Fail-Safe Therapy by Gamma-Ray Irradiation Against Tumor Formation by Human-Induced Pluripotent Stem Cell-Derived Neural Progenitors

  Mitsuko Katsukawa; Yusuke Nakajima; Akiko Fukumoto; Daisuke Doi; Jun Takahashi

  STEM CELLS AND DEVELOPMENT, Jun. 2016, Peer-reviewed

  
• Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin alpha 5 beta 1

  Kaneyasu Nishimura; Daisuke Doi; Bumpei Samata; Shigeo Murayama; Tsuyoshi Tahara; Hirotaka Onoe; Jun Takahashi

  STEM CELL REPORTS, Apr. 2016, Peer-reviewed

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• WNT-059, a Small-Molecule WNT Inhibitor, Efficiently Induces Anterior Cortex That Includes Cortical Motor Neurons From Human Pluripotent Stem Cells

  Makoto Motono; Yoshihiko Ioroi; Takenori Ogura; Jun Takahashi

  STEM CELLS TRANSLATIONAL MEDICINE, Apr. 2016, Peer-reviewed

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• Cell therapy for Parkinson’s disease

  Asuka Morizane; Jun Takahashi

  Neurologia Medico-Chirurgica, 15 Mar. 2016, Peer-reviewed, Invited

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• 【出血性脳血管障害】出血発症成人もやもや病とその外科治療 Japan Adult Moyamoya Trialの結果を中心に

  宮本 享; 高橋 淳; 舟木 健史; JAM Trial Group

  脳神経外科ジャーナル, Jan. 2016, Peer-reviewed

  
• Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue

  Hideya Sakaguchi; Taisuke Kadoshima; Mika Soen; Nobuhiro Narii; Yoshihito Ishida; Masatoshi Ohgushi; Jun Takahashi; Mototsugu Eiraku; Yoshiki Sasai

  NATURE COMMUNICATIONS, Nov. 2015, Peer-reviewed

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• Identification of Neurexophilin 3 as a Novel Supportive Factor for Survival of Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors

  Kaneyasu Nishimura; Shigeo Murayama; Jun Takahashi

  STEM CELLS TRANSLATIONAL MEDICINE, Aug. 2015, Peer-reviewed

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• 【Stroke 2015-脳卒中対策基本法制定、脳卒中治療ガイドライン改訂を前に】Japan Adult Moyamoya Trialの概要

  舟木 健史; 高橋 淳; 宮本 享

  脳神経外科速報, Apr. 2015, Peer-reviewed

  
• Modeling the Early Phenotype at the Neuromuscular Junction of Spinal Muscular Atrophy Using Patient-Derived iPSCs

  Michiko Yoshida; Shiho Kitaoka; Naohiro Egawa; Mayu Yamane; Ryunosuke Ikeda; Kayoko Tsukita; Naoki Amano; Akira Watanabe; Masafumi Morimoto; Jun Takahashi; Hajime Hosoi; Tatsutoshi Nakahata; Haruhisa Inoue; Megumu K. Saito

  STEM CELL REPORTS, Apr. 2015, Peer-reviewed

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• X-linked severe combined immunodeficiency (X-SCID) rats for xeno-transplantation and behavioral evaluation

  Bumpei Samata; Tetsuhiro Kikuchi; Yoshifumi Miyawaki; Asuka Morizane; Tomoji Mashimo; Masato Nakagawa; Keisuke Okita; Jun Takahashi

  JOURNAL OF NEUROSCIENCE METHODS, Mar. 2015, Peer-reviewed

  
• パーキンソン病患者由来iPSCからのドパミン神経誘導

  菊地哲広; 森実飛鳥; 土井大輔; 井上治久; 高橋良輔; 沖田圭介; 中川誠人; 高橋淳

  再生医療, 01 Feb. 2015

  
• Induction and Transplantation of Neural Stem Cells from Human Pluripotent Stem Cells in Experimental Models (Rat) of Parkinson's disease

  Makoto Motono; Asuka Morizane; Jun Takahashi

  Neural Stem Cell Assays, 30 Jan. 2015, Peer-reviewed

  
• Risk of Tumorigenesis and Patient Hope

  Misao Fujita; Taichi Hatta; Tsutomu Sawai; Jun Takahashi

  AJOB Neuroscience, 02 Jan. 2015, Peer-reviewed

  
• 【知っておくべき脳卒中最新治療】もやもや病出血予防のための手術療法

  舟木 健史; 高橋 淳; 宮本 享

  診断と治療, Jan. 2015, Peer-reviewed

  
• 各種疾患 脳血管障害 もやもや病の再出血予防(Japan Adult Moyamoya Trial)

  舟木 健史; 高橋 淳; 宮本 享

  Annual Review神経, Jan. 2015, Peer-reviewed

  
• 【最新臨床脳卒中学[下]-最新の診断と治療-】日本における大規模臨床試験 Japan Adult Moyamoya(JAM)Trial

  宮本 享; 高橋 淳; 舟木 健史

  日本臨床, Oct. 2014, Peer-reviewed

  
• iPS細胞にとっての組織適合性 iPS細胞を用いた脳内細胞移植治療における免疫原性の検討

  森実 飛鳥; 土井 大輔; 菊地 哲広; 沖田 圭介; 水間 広; 尾上 浩隆; 林 拓也; 椎名 隆; 小笠原 一誠; 山中 伸弥; 高橋 淳

  MHC: Major Histocompatibility Complex, Apr. 2014

  
• Isolation of Human Induced Pluripotent Stem Cell-Derived Dopaminergic Progenitors by Cell Sorting for Successful Transplantation

  Daisuke Doi; Bumpei Samata; Mitsuko Katsukawa; Tetsuhiro Kikuchi; Asuka Morizane; Yuichi Ono; Kiyotoshi Sekiguchi; Masato Nakagawa; Malin Parmar; Jun Takahashi

  STEM CELL REPORTS, Mar. 2014, Peer-reviewed

  
• A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells

  Masato Nakagawa; Yukimasa Taniguchi; Sho Senda; Nanako Takizawa; Tomoko Ichisaka; Kanako Asano; Asuka Morizane; Daisuke Doi; Jun Takahashi; Masatoshi Nishizawa; Yoshinori Yoshida; Taro Toyoda; Kenji Osafune; Kiyotoshi Sekiguchi; Shinya Yamanaka

  SCIENTIFIC REPORTS, Jan. 2014, Peer-reviewed

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• Differentiation-defective phenotypes revealed by large-scale analyses of human pluripotent stem cells

  Michiyo Koyanagi-Aoi; Mari Ohnuki; Kazutoshi Takahashi; Keisuke Okita; Hisashi Noma; Yuka Sawamura; Ito Teramoto; Megumi Narita; Yoshiko Sato; Tomoko Ichisaka; Naoki Amano; Akira Watanabe; Asuka Morizane; Yasuhiro Yamada; Tosiya Sato; Jun Takahashi; Shinya Yamanaka

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 2013, Peer-reviewed

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• 【脳動脈瘤治療に残る課題】治療困難な脳動脈瘤 開頭手術に残された課題

  菊池 隆幸; 宮本 享; 高橋 淳; 舟木 健史

  脳神経外科ジャーナル, Oct. 2013, Peer-reviewed

  
• Direct Comparison of Autologous and Allogeneic Transplantation of iPSC-Derived Neural Cells in the Brain of a Nonhuman Primate

  Asuka Morizane; Daisuke Doi; Tetsuhiro Kikuchi; Keisuke Okita; Akitsu Hotta; Toshiyuki Kawasaki; Takuya Hayashi; Hirotaka Onoe; Takashi Shiina; Shinya Yamanaka; Jun Takahashi

  STEM CELL REPORTS, Oct. 2013, Peer-reviewed

  
• Response to comment on "Drug screening for ALS using patient-specific induced pluripotent stem cells".

  Naohiro Egawa; Shiho Kitaoka; Kayoko Tsukita; Motoko Naitoh; Kazutoshi Takahashi; Takuya Yamamoto; Fumihiko Adachi; Takayuki Kondo; Keisuke Okita; Isao Asaka; Takashi Aoi; Akira Watanabe; Yasuhiro Yamada; Asuka Morizane; Jun Takahashi; Takashi Ayaki; Hidefumi Ito; Katsuhiro Yoshikawa; Satoko Yamawaki; Shigehiko Suzuki; Dai Watanabe; Hiroyuki Hioki; Takeshi Kaneko; Kouki Makioka; Koichi Okamoto; Hiroshi Takuma; Akira Tamaoka; Kazuko Hasegawa; Takashi Nonaka; Masato Hasegawa; Akihiro Kawata; Minoru Yoshida; Tatsutoshi Nakahata; Ryosuke Takahashi; Maria C N Marchetto; Fred H Gage; Shinya Yamanaka; Haruhisa Inoue

  Science translational medicine, 05 Jun. 2013, Peer-reviewed

  
• Neural Induction with a Dopaminergic Phenotype from Human Pluripotent Stem Cells Through a Feeder-Free Floating Aggregation Culture

  Morizane A; Doi D; Takahashi J

  Methods in Molecular Biology, May 2013, Peer-reviewed

  
• Therapeutic Application of Stem Cell Technology toward the Treatment of Parkinson's Disease

  Kaneyasu Nishimura; Jun Takahashi

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Feb. 2013, Peer-reviewed

  
• gamma-Secretase Inhibitors Prevent Overgrowth of Transplanted Neural Progenitors Derived from Human-Induced Pluripotent Stem Cells

  Aya Ogura; Asuka Morizane; Yusuke Nakajima; Susumu Miyamoto; Jun Takahashi

  STEM CELLS AND DEVELOPMENT, Feb. 2013, Peer-reviewed

  
• Systemic administration of valproic acid and zonisamide promotes differentiation of induced pluripotent stem cell-derived dopaminergic neurons

  Tatsuya Yoshikawa; Bumpei Samata; Aya Ogura; Susumu Miyamoto; Jun Takahashi

  FRONTIERS IN CELLULAR NEUROSCIENCE, Feb. 2013, Peer-reviewed

  
• Drug screening for ALS using patient-specific induced pluripotent stem cells.

  Naohiro Egawa; Shiho Kitaoka; Kayoko Tsukita; Motoko Naitoh; Kazutoshi Takahashi; Takuya Yamamoto; Fumihiko Adachi; Takayuki Kondo; Keisuke Okita; Isao Asaka; Takashi Aoi; Akira Watanabe; Yasuhiro Yamada; Asuka Morizane; Jun Takahashi; Takashi Ayaki; Hidefumi Ito; Katsuhiro Yoshikawa; Satoko Yamawaki; Shigehiko Suzuki; Dai Watanabe; Hiroyuki Hioki; Takeshi Kaneko; Kouki Makioka; Koichi Okamoto; Hiroshi Takuma; Akira Tamaoka; Kazuko Hasegawa; Takashi Nonaka; Masato Hasegawa; Akihiro Kawata; Minoru Yoshida; Tatsutoshi Nakahata; Ryosuke Takahashi; Maria C N Marchetto; Fred H Gage; Shinya Yamanaka; Haruhisa Inoue

  Science translational medicine, 01 Aug. 2012, Peer-reviewed

  
• Functional recovery of the murine brain ischemia model using human induced pluripotent stem cell-derived telencephalic progenitors.

  Masanori Gomi; Yasushi Takagi; Asuka Morizane; Daisuke Doi; Masaki Nishimura; Susumu Miyamoto; Jun Takahashi

  Brain research, 12 Jun. 2012, Peer-reviewed

  
• Selective white matter abnormalities in a novel rat model of vascular dementia

  Akihiro Kitamura; Youshi Fujita; Naoya Oishi; Raj N. Kalaria; Kazuo Washida; Takakuni Maki; Yoko Okamoto; Yoshiki Hase; Mahito Yamada; Jun Takahashi; Hidefumi Ito; Hidekazu Tomimoto; Hidenao Fukuyama; Ryosuke Takahashi; Masafumi Ihara

  NEUROBIOLOGY OF AGING, May 2012, Peer-reviewed

  
• Prolonged Maturation Culture Favors a Reduction in the Tumorigenicity and the Dopaminergic Function of Human ESC-Derived Neural Cells in a Primate Model of Parkinson's Disease

  Daisuke Doi; Asuka Morizane; Tetsuhiro Kikuchi; Hirotaka Onoe; Takuya Hayashi; Toshiyuki Kawasaki; Makoto Motono; Yoshiki Sasai; Hidemoto Saiki; Masanori Gomi; Tatsuya Yoshikawa; Hideki Hayashi; Mizuya Shinoyama; Mohamed M. Refaat; Hirofumi Suemori; Susumu Miyamoto; Jun Takahashi

  STEM CELLS, May 2012, Peer-reviewed

  
• Transplantation of telencephalic neural progenitors induced from embryonic stem cells into subacute phase of focal cerebral ischemia

  Motoaki Fujimoto; Hideki Hayashi; Yasushi Takagi; Makoto Hayase; Takeshi Marumo; Masanori Gomi; Masaki Nishimura; Hiroharu Kataoka; Jun Takahashi; Nobuo Hashimoto; Kazuhiko Nozaki; Susumu Miyamoto

  Laboratory Investigation, Apr. 2012, Peer-reviewed

  
• Cytotoxic T lymphocyte antigen 4 immunogloblin promotes neuronal differentiation in the grafts of embryonic stem cell-derived neural precursor cells

  M. Shinoyama; M. Ideguchi; H. Hayashi; D. Doi; N. Hashimoto; M. Suzuki; J. Takahashi

  Neuroscience, 27 Jan. 2012, Peer-reviewed

  
• Objective and quantitative evaluation of primate model of Parkinson's disease

  Hidemoto Saiki; Jun Takahashi

  2012 ICME International Conference on Complex Medical Engineering, CME 2012 Proceedings, 2012, Peer-reviewed

  
• A challenge towards the clinical application of induced pluripotent stem cell technology for the treatment of Parkinson's disease

  Asuka Morizane; Jun Takahashi

  Brain and Nerve, 01 Jan. 2012, Peer-reviewed

  
• Single and Local Blockade of Interleukin-6 Signaling Promotes Neuronal Differentiation From Transplanted Embryonic Stem Cell-Derived Neural Precursor Cells

  Masanori Gomi; Tomohiro Aoki; Yasushi Takagi; Masaki Nishimura; Yoshiyuki Ohsugi; Masahiko Mihara; Kazuhiko Nozaki; Nobuo Hashimoto; Susumu Miyamoto; Jun Takahashi

  JOURNAL OF NEUROSCIENCE RESEARCH, Sep. 2011, Peer-reviewed

  
• A more efficient method to generate integration-free human iPS cells

  Keisuke Okita; Yasuko Matsumura; Yoshiko Sato; Aki Okada; Asuka Morizane; Satoshi Okamoto; Hyenjong Hong; Masato Nakagawa; Koji Tanabe; Ken-Ichi Tezuka; Toshiyuki Shibata; Takahiro Kunisada; Masayo Takahashi; Jun Takahashi; Hiroh Saji; Shinya Yamanaka

  Nature Methods, May 2011, Peer-reviewed

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• Small-molecule inhibitors of bone morphogenic protein and activin/nodal signals promote highly efficient neural induction from human pluripotent stem cells.

  Asuka Morizane; Daisuke Doi; Tetsuhiro Kikuchi; Kaneyasu Nishimura; Jun Takahashi

  Journal of neuroscience research, Feb. 2011, Peer-reviewed

  
• Survival of Human Induced Pluripotent Stem Cell-Derived Midbrain Dopaminergic Neurons in the Brain of a Primate Model of Parkinson's Disease

  Tetsuhiro Kikuchi; Asuka Morizane; Daisuke Doi; Hirotaka Onoe; Takuya Hayashi; Toshiyuki Kawasaki; Hidemoto Saiki; Susumu Miyamoto; Jun Takahashi

  JOURNAL OF PARKINSONS DISEASE, 2011, Peer-reviewed

  
• マウス慢性脳低灌流モデルの認知機能障害および白質障害に対するテルミサルタンの効果

  鷲田 和夫; 猪原 匡史; 西尾 佳子; 藤田 裕之; 眞木 崇州; 山田 真人; 高橋 淳; 呉 暁峰; 木原 武士; 伊東 秀文; 冨本 秀和; 高橋 良輔

  脳循環代謝, Nov. 2010

  
• 血管性認知症モデルマウスの認知機能障害および白質障害に対するテルミサルタンの効果

  鷲田 和夫; 猪原 匡史; 西尾 佳子; 藤田 裕之; 眞木 崇州; 山田 真人; 高橋 淳; 呉 暁峰; 木原 武士; 伊東 秀文; 冨本 秀和; 高橋 良輔

  Dementia Japan, Sep. 2010

  
• 血管性認知症モデルマウスの認知機能障害および白質病変に対するテルミサルタンの効果(Nonhypotensive dose of telmisartan attenuates cognitive impairment partially due to PPAR-γ activation in mice with chronic cerebral hypoperfusion)

  鷲田 和夫; 猪原 匡史; 西尾 佳子; 藤田 祐之; 眞木 崇州; 山田 真人; 高橋 淳; 呉 暁峰; 木原 武士; 伊東 秀文; 冨本 秀和; 高橋 良輔

  神経化学, Aug. 2010

  
• Nonhypotensive dose of telmisartan attenuates cognitive impairment partially due to peroxisome proliferator-activated receptor-γ activation in mice with chronic cerebral hypoperfusion

  Kazuo Washida; Masafumi Ihara; Keiko Nishio; Youshi Fujita; Takakuni Maki; Mahito Yamada; Jun Takahashi; Xiaofeng Wu; Takeshi Kihara; Hidefumi Ito; Hidekazu Tomimoto; Ryosuke Takahashi

  Stroke, Aug. 2010, Peer-reviewed

  
• Objective and quantitative evaluation of motor function in a monkey model of Parkinson's disease

  Hidemoto Saiki; Takuya Hayashi; Ryosuke Takahashi; Jun Takahashi

  JOURNAL OF NEUROSCIENCE METHODS, Jul. 2010, Peer-reviewed

  
• Matrigel Supports Survival and Neuronal Differentiation of Grafted Embryonic Stem Cell-Derived Neural Precursor Cells

  Makoto Uemura; Mohamed M. Refaat; Mizuya Shinoyama; Hideki Hayashi; Nobuo Hashimoto; Jun Takahashi

  JOURNAL OF NEUROSCIENCE RESEARCH, Feb. 2010, Peer-reviewed

  
• Embryonic stem cell transplantation for the treatment of Parkinson's disease

  Asuka Morizane; Jun Takahashi

  Perspectives of Stem Cells: From Tools for Studying Mechanisms of Neuronal Differentiation towards Therapy, 2010, Peer-reviewed

  
• 解剖を中心とした脳神経手術手技 後頭蓋窩巨大脳動脈瘤に対するflow alteration treatment

  宮本 享; 舟木 健史; 高橋 淳; 飯原 弘二

  Neurological Surgery, Dec. 2009, Peer-reviewed

  
• パーキンソン病の再生医療--ES細胞,iPS細胞を用いた細胞移植治療の展望 (特集 Regenerative Medicine--期待される21世紀の新しい医療) -- (脳神経領域)

  森実 飛鳥; 高橋 淳

  綜合臨床, Jan. 2009, Peer-reviewed

  
• ES 細胞，iPS 細胞を用いた細胞移植治療の臨床応用－Clinical Application of Cell Transplantation Using Pluripotent Stem Cell－

  森実飛鳥; 高橋淳

  月刊バイオインダストリー26（7）: 34－39（2009）, 2009, Peer-reviewed

  
• Minimization of exogenous signals in ES cell culture induces rostral hypothalamic differentiation

  Takafumi Wataya; Satoshi Ando; Keiko Muguruma; Hanako Ikeda; Kiichi Watanabe; Mototsugu Eiraku; Masako Kawada; Jun Takahashi; Nobuo Hashimoto; Yoshiki Sasai

  Proceedings of the National Academy of Sciences of the United States of America, 19 Aug. 2008, Peer-reviewed

  
• Immune or inflammatory response by the host brain suppresses neuronal differentiation of transplanted ES cell-derived neural precursor cells

  Makoto Ideguchi; Mizuya Shinoyama; Masanori Gomi; Hideki Hayashi; Nobuo Hashimoto; Jun Takahashi

  JOURNAL OF NEUROSCIENCE RESEARCH, Jul. 2008, Peer-reviewed

  
• [Ictal Gerstmann's syndrome in a patient with symptomatic parietal lobe epilepsy].

  Akihiro Shimotake; Youshi Fujita; Akio Ikeda; Hidekazu Tomimoto; Jun Takahashi; Ryosuke Takahashi

  Rinsho shinkeigaku = Clinical neurology, Mar. 2008

  
• Inhibition of the Rho/ROCK pathway reduces apoptosis during transplantation of embryonic stem cell-derived neural precursors

  Masaomi Koyanagi; Jun Takahashi; Yoshiki Arakawa; Daisuke Doi; Hitoshi Fukuda; Hideki Hayashi; Shuh Narumiya; Nobuo Hashimoto

  Journal of Neuroscience Research, 01 Feb. 2008, Peer-reviewed

  
• Meningeal cells induce dopaminergic neurons from embryonic stem cells

  Hideki Hayashi; Asuka Morizane; Masaomi Koyanagi; Yuichi Ono; Yoshiki Sasai; Nobuo Hashimoto; Jun Takahashi

  European Journal of Neuroscience, Jan. 2008, Peer-reviewed

  
• Differences in neurogenic potential in floor plate cells along an anteroposterior location: Midbrain dopaminergic neurons originate from mesencephalic floor plate cells

  Yuichi Ono; Tomoya Nakatani; Yoshimasa Sakamoto; Eri Mizuhara; Yasuko Minaki; Minoru Kumai; Akiko Hamaguchi; Miyuki Nishimura; Yoko Inoue; Hideki Hayashi; Jun Takahashi; Toshio Imai

  Development, Sep. 2007, Peer-reviewed

  
• Subtemporal hippocampectomy preserving the basal temporal language area for intractable mesial temporal lobe epilepsy: Preliminary results

  Nobuhiro Mikuni; Susumu Miyamoto; Akio Ikeda; Takeshi Satow; Junya Taki; Jun Takahashi; Yoshitaka Ohigashi; Nobuo Hashimoto

  EPILEPSIA, Aug. 2006, Peer-reviewed

  
• Primate embryonic stem cell-derived neuronal progenitors transplanted into ischemic brain

  Junya Hayashi; Yasushi Takagi; Hitoshi Fukuda; Takayuki Imazato; Masaki Nishimura; Motoaki Fujimoto; Jun Takahashi; Nobuo Hashimoto; Kazuhiko Nozaki

  Journal of Cerebral Blood Flow and Metabolism, 19 Jun. 2006, Peer-reviewed

  
• Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: Effect of in vitro differentiation on graft survival and teratoma formation

  Anke Brederlau; Ana Sofia Correia; Sergey V. Anisimov; Muna Elmi; Gesine Paul; Laurent Roybon; Asuka Morizane; Filip Bergquist; Ilse Riebe; Ulf Nannmark; Manolo Carta; Erik Hanse; Jun Takahashi; Yoshiki Sasai; Keiko Funa; Patrick Brundin; Peter S. Eriksson; Jia-Yi Li

  Stem Cells, Jun. 2006, Peer-reviewed

  
• Generation of graftable dopaminergic neuron progenitors from mouse ES cells by a combination of coculture and neurosphere methods

  Asuka Morizane; Jim Takahashi; Mizuya Shinoyama; Makoto Ideguchi; Yasushi Takagi; Hitoshi Fukuda; Masaomi Koyanagi; Yoshiki Sasai; Nobuo Hashimoto

  Journal of Neuroscience Research, 01 May 2006, Peer-reviewed

  
• Clinical outcome of patients with SREDA (subclinical rhythmic EEG discharge of adults)

  Tahamina Begum; Akio Ikeda; Jun Takahashi; Hidekazu Tomimoto; Shun Shimohama; Takeshi Satow; Takashi Nagamine; Hidenao Fukuyama; Hiroshi Shibasaki

  Internal Medicine, 01 Mar. 2006, Peer-reviewed

  
• Fluorescence-activated cell sorting-based purification of embryonic stem cell-derived neural precursors averts tumor formation after transplantation

  Hitoshi Fukuda; Jun Takahashi; Kiichi Watanabe; Hideki Hayashi; Asuka Morizane; Masaomi Koyanagi; Yoshiki Sasai; Nobuo Hashimoto

  Stem Cells, Mar. 2006, Peer-reviewed

  
• Survival and differentiation of neural progenitor cells derived from embryonic stem cells and transplanted into ischemic brain

  Yasushi Takagi; Masaki Nishimura; Asuka Morizane; Jun Takahashi; Kazuhiko Nozaki; Junya Hayashi; Nobuo Hashimoto

  Journal of Neurosurgery, Aug. 2005, Peer-reviewed

  
• Estrogen promotes differentiation and survival of dopaminergic neurons derived from human neural stem cells

  Yo Kishi; Jun Takahashi; Masaomi Koyanagi; Asuka Morizane; Yo Okamoto; Satoshi Horiguchi; Kei Tashiro; Tasuku Honjo; Shingo Fujii; Nobuo Hashimoto

  Journal of Neuroscience Research, 01 Feb. 2005, Peer-reviewed

  
• Dopaminergic neurons generated from monkey embryonic stem cells function in a Parkinson primate model

  Yasushi Takagi; Jun Takahashi; Hidemoto Saiki; Asuka Morizane; Takuya Hayashi; Yo Kishi; Hitoshi Fukuda; Yo Okamoto; Masaomi Koyanagi; Makoto Ideguchi; Hideki Hayashi; Takayuki Imazato; Hiroshi Kawasaki; Hirofumi Suemori; Shigeki Omachi; Hidehiko Iida; Nobuyuki Itoh; Norio Nakatsuji; Yoshiki Sasai; Nobuo Hashimoto

  Journal of Clinical Investigation, 2005, Peer-reviewed

  
• Neural Precursor Cells Derived from Human Embryonic Brain Retain Regional Specificity

  Satoshi Horiguchi; Jun Takahashi; Yo Kishi; Asuka Morizane; Yo Okamoto; Masaomi Koyanagi; Masayuki Tsuji; Kei Tashiro; Tasuku Honjo; Shingo Fujii; Nobuo Hashimoto

  Journal of Neuroscience Research, 15 Mar. 2004, Peer-reviewed

  
• A Combined Subtemporal and Transventricular/Transchoroidal Fissure Approach to Medial Temporal Lesions

  Susumu Miyamoto; Hiroharu Kataoka; Akio Ikeda; Jun Takahashi; Nobuhiro Mikuni; Keiko Usui; Motohiro Takayama; Takeshi Satow; Nobuo Hashimoto; David W. Roberts; David Rojas-Zalazar; Jorge Mura; Evandro De Oliveira; Ivan S. Ciric; M. Gazi Yaşargil; Saleem I. Abdulrauf

  Neurosurgery, 2004, Peer-reviewed

  
• Optimal conditions for in vivo induction of dopaminergic neurons from embryonic stem cells through stromal cell-derived inducing activity

  Asuka Morizane; Jun Takahashi; Yasushi Takagi; Yoshiki Sasai; Nobuo Hashimoto

  Journal of Neuroscience Research, 15 Sep. 2002, Peer-reviewed

  
• Neurons generated from adult rat hippocampal stem cells form functional glutamatergic and GABAergic synapses in vitro

  Hiroki Toda; Jun Takahashi; Akira Mizoguchi; Konomi Koyano; Nobuo Hashimoto

  Experimental Neurology, 2000, Peer-reviewed

  
• Regeneration of the central nervous system by cell transplantation

  J. Takahashi

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2000, Peer-reviewed

  
• Proliferation of neuronal precursor cells in the dentate gyms is accelerated after transient forebrain ischemia in mice

  Yasushi Takagi; Kazuhiko Nozaki; Jun Takahashi; Junji Yodoi; Masatsune Ishikawa; Nobuo Hashimoto

  Brain Research, 12 Jun. 1999, Peer-reviewed

  
• Seizure with prominent tonic initial signs followed by psychomotor features: A case report clinically manifesting an unusual ictal evolution

  Akio Ikeda; Akira Sengoku; Nobuhisa Aoyagi; Yasutaka Kubota; Riki Matsumoto; Shinji Ohara; Takeharu Kunieda; Kaku Kimura; Jun Takahashi; Susumu Miyamoto; Hiroshi Shibasaki

  Epileptic Disorders, 1999, Peer-reviewed

  
• Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina

  Masayo Takahashi; Theo D. Palmer; Jun Takahashi; Fred H. Gage

  Molecular and Cellular Neurosciences, 1998, Peer-reviewed

  
• A successful surgical removal of a ventral, midbrain, cavernous angioma by using a pterional approach: A case report

  M. Morimoto; S. Miyamoto; H. Kikuchi; I. Nagata; J. Takahashi

  Japanese Journal of Neurosurgery, 1996, Peer-reviewed

  

Misc.

• 日本人のアテローム血栓性脳梗塞の強力な遺伝子多型RNF213 p.4810K

  猪原 匡史; 岡崎 周平; 森本 貴昭; 鎌谷 洋一郎; 上村 鉄平; 原田 浩二; 冨田 努; 東山 綾; 高橋 淳; 中川原 譲二; 古賀 政利; 豊田 一則; 鷲田 和夫; 齊藤 聡; 望月 秀樹; 秦 淳; 二宮 利治; 吾郷 哲朗; 久保 充明; 小泉 昭夫

  臨床神経学, Nov. 2019

  
• pineal parenchymal tumor of intermediate differentiationの病理所見と治療方法の検討

  高橋 潤; 荒川 芳輝; 織田 雅; 香月 教寿; 大野 誠; 高橋 淳; 橋本 信夫; 中嶋 安彬

  Brain Tumor Pathology, Apr. 2005

  
• Does cerebral perfusion reserve reflect oxgen extraction fraction? - Analysis on intensity-filtered VOI method.

  T Hayashi; H Watabe; H Moriwaki; Y Hasegawa; J Takahashi; K Fukuchi; K Hayashida; H Iida

  JOURNAL OF NUCLEAR MEDICINE, May 2002

  
• パーキンソン病に対する再生医療とリハビリテーション

  森実飛鳥; 高橋 淳

  総合リハビリテーション, 2021

  
• Regenerative medicine by using ES cells and iPS cells

  高橋 淳; 森実 飛鳥

  Japanese journal of clinical medicine, Jun. 2009

  
• 成人型もやもや病に対する外科治療 (特集 ガイドライン時代の脳卒中の治療--ガイドライン利用の意義とその適応の限界)

  宮本 享; 野中 裕康; 高橋 淳

  救急医学, Sep. 2005

  
• Management of intracranial arteriovenous malformations

  宮本 享; 高橋 淳

  Brain and nerve, Oct. 2008

  
• 荒木千里記念脳外科症例検討研究会記録(241)脳底動脈部分血栓化巨大動脈瘤に対しHunterian ligationを行うもregrowthを来した一例--その後の治療方針

  野中 裕康; 高橋 淳; 宮本 享

  北野病院紀要, 2003

  
• プロポフォールがirritable zone,seizure onset zoneの皮質脳波に与える影響

  芝田純也; 國枝武治; 中江卓郎; 西田誠; 稲野理賀; 山尾幸広; 荒川芳輝; 菊池隆幸; 吉田和道; 高木康志; 高橋淳; 松本理器; 池田昭夫; 宮本享

  てんかん研究, 2013

  
• カニクイザルのiPS細胞ならびに分化細胞におけるMHC遺伝子発現解析

  椎名隆; 山田幸穂; 森実飛鳥; 杉田直; 河村拓史; 石垣宏仁; 高橋淳; 高橋政代; 澤芳樹; 小笠原一誠

  日本組織適合性学会大会抄録集, 31 Aug. 2015

  
• 6. Microsurgical Anatomy of the Tentorial Incisura(PS2-1 The 25th Microneurosurgical Anatomy Seminar "Anatomy and Surgery in the Temporal Lobe and its Surrounding Tissues",Plenary Session,Professional Spirit and Research Mind of Neurosurgeons,The 31st Annual Meeting of The Japanese Congress of Neurological Surgeons)

  Takahashi Jun

  Japanese journal of neurosurgery, 10 Apr. 2011

  
• Using Aneurysm Clips : Appropriate Choice and Optimal Applications

  TAKAHASHI Jun C.; MIYAMOTO Susumu

  Japanese journal of neurosurgery, 20 Jul. 2010

  
• iPSC-derived cell therapy for Parkinson's disease

  土井 大輔; 高橋 淳

  生体の科学, Jul. 2016

  
• Parkinson病に対する神経細胞移植 (特集 移植療法の現況と今後の展望) -- (組織,細胞移植)

  森実 飛鳥; 高橋 淳

  診断と治療, Oct. 2014

  
• Nonhypotensive dose of telmisartan attenuates cognitive impairment partially due to PPAR-gamma activation in mice with chronic cerebral hypoperfusion

  Kazuo Washida; Masafumi Ihara; Keiko Nishio; Youshi Fujita; Takakuni Maki; Mahito Yamada; Jun Takahashi; Xiaofeng Wu; Takeshi Kihara; Hidefumi Ito; Hidekazu Tomimoto; Ryosuke Takahashi

  NEUROSCIENCE RESEARCH, 2010

  
• Clinical application of cell therapy for Parkinson's disease

  森実 飛鳥; 高橋 淳

  医学のあゆみ, 05 Aug. 2017

  
• Cell therapy for Parkinson's disease

  森実 飛鳥; 高橋 淳

  医学のあゆみ, 18 Feb. 2017

  
• Cell therapy for Parkinson's disease

  森実 飛鳥; 高橋 淳

  老年精神医学雑誌, Nov. 2014

  
• わが国における妊産婦と脳血管障害 : 平成22年･23年日本脳神経外科学会による悉皆調査報告 (特集 妊産婦と脳血管疾患)

  髙橋 淳; 宮本 享

  産科と婦人科, May 2014

  
• Cell therapy for Parkinson's disease

  菊地 哲広; 高橋 淳

  医学のあゆみ, 31 Dec. 2011

  
• Cell Transplantation Therapy for Parkinson's Disease

  菊地 哲広; 髙橋 淳

  最新醫學 = The medical frontline, Jun. 2017

  
• 神経難病と再生医療 (特集 難病対策)

  土井 大輔; 髙橋 淳

  公衆衛生, Jun. 2016

  
• カニクイザルiPS細胞を用いた脳内神経細胞同種移植

  森実飛鳥; 土井大輔; 菊地哲広; 沖田圭介; 高良沙幸; 水間広; 尾上浩隆; 林拓也; 椎名隆; 石垣宏仁; 小笠原一誠; 高橋淳; 高橋淳

  再生医療, 01 Feb. 2016

  
• Research toward the clinical application of cell therapy for Parkinson's disease with induced pluripotent stem cells

  森実 飛鳥; 高橋 淳

  麻酔, Nov. 2015

  
• iPS cell modeling of genetic Parkinson's disease

  Yasushi Koshiba; Hodaka Yamakado; Asuka Morizane; Tetsuhiro Kikuchi; Kazuko Hasegawa; Haruhisa Inoue; Jun Takahashi; Ryosuke Takahashi

  MOVEMENT DISORDERS, Nov. 2014

  
• 妊娠に関連する脳卒中と治療指針 (特集 若年・壮年期の脳卒中とリハビリテーション)

  吉田 和道; 高橋 淳; 宮本 享

  Monthly book medical rehabilitation, Jul. 2014

  
• パーキンソン病のVisual View パーキンソン病とiPS細胞技術

  土井 大輔; 髙橋 淳

  Frontiers in Parkinson disease, May 2014

  
• iPS細胞由来ドパミン神経移植の臨床応用へのストラテジー~自家移植およびHLA適合移植の可能性~

  森実飛鳥; 土井大輔; 菊地哲広; 沖田圭介; 水間広; 尾上浩隆; 林拓也; 椎名隆; 小笠原一誠; 山中伸弥; 高橋淳

  再生医療, 27 Jan. 2014

  
• 嚢胞成分による閉塞性水頭症に対して内視鏡的アプローチを行い著効した下垂体腺腫の一例

  森田康平; 荒川芳輝; 姜裕; 國枝武治; 高橋淳; 高木康志; 宮本享

  日本間脳下垂体腫瘍学会プログラム・抄録集, 2014

  
• Isolation of new supportive factor for survival of iPSC-derived dopaminergic neurons

  Kaneyasu Nishimura; Jun Takahashi

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014

  
• Systemic administration of valproic acid and zonisamide promotes differentiation of induced pluripotent stem cell-derived dopaminergic neurons (vol 7, 11, 2013)

  Tatsuya Yoshikawa; Bumpei Samata; Aya Ogura; Susumu Miyamoto; Jun Takahashi

  FRONTIERS IN CELLULAR NEUROSCIENCE, Jul. 2013

  
• パーキンソン病に対する幹細胞移植治療の実現化 (再生医療の実現化ハイウェイ) -- (中長期での臨床研究への到達を目指す再生医療研究)

  高橋 淳; 森実 飛鳥

  再生医療 : 日本再生医療学会雑誌, May 2013

  
• 間脳下垂体疾患診療における3T MRI装置を用いた術前検査の有用性の検討

  北条雅人; 山本憲; 五百蔵義彦; 安藤充重; 荒川芳輝; 高橋淳; 高木康志; 宮本享

  日本間脳下垂体腫瘍学会プログラム・抄録集, 2013

  
• Gliadel留置後の症候性脳浮腫に対するbevacizumab療法

  福井伸行; 福井伸行; 荒川芳輝; 小野功朗; 國枝武治; 高木康志; 高橋淳; 宮本享

  日本脳腫瘍学会プログラム・抄録集, 2013

  
• サルiPS細胞による神経分化誘導:自家移植モデルを目指して

  森実飛鳥; 沖田圭介; 土井大輔; 菊地哲広; 高橋淳

  再生医療, 16 May 2012

  
• ES，iPS 細胞を用いたパーキンソン病治療

  高橋淳

  第40 回日本救急医学会総会・学術集会（2012.11.15．京都）, 2012, Peer-reviewed

  
• ES, iPS 細胞を用いた，パーキンソン病に対する細胞移植治療

  高橋淳

  日本脳神経外科学会第71 回学術総会 （2012.10.17．大阪）, 2012, Peer-reviewed

  
• iPS 細胞を用いたパーキンソン病治療の開発研究CiRA Mini-Symposium -iPA 細胞

  高橋淳

  新しい医学への可能性−（2012.10.10．京都）, 2012, Peer-reviewed

  
• iPS 細胞技術と直接誘導法を用いた神経系の再生・疾患研究

  高橋淳

  文部科学省iPS 細胞等研究ネットワーク 第4 回合同シンポジウム「再生医学研究の最前線」（2012.06.17．横浜）, 2012, Peer-reviewed

  
• 再生医学は脳卒中を救えるか

  高橋淳

  市民公開講座脳卒中にならない脳卒中に負けない（2012.06.10．京都）, 2012, Peer-reviewed

  
• パーキンソン病に対する幹細胞治療のための開発研究

  高橋淳

  再生医療の実用化に関するニーズ発表会 （2012.02.24．神戸）, 2012, Peer-reviewed

  
• パーキンソン病に対する幹細胞移植 −医工学フォーラム−

  高橋淳

  2011 年度特別学術講演会（2012.02.22．京都）, 2012, Peer-reviewed

  
• パーキンソン病に対する多能性幹細胞移植研究

  高橋淳

  第2 回神経再生医療研究会in Sapporo（2012.02.08．札幌）, 2012, Peer-reviewed

  
• パーキンソン病に対する幹細胞移植治療の実現化に向けての前臨床研究

  高橋淳

  関西広域バイオメディカルクラスター成果報告会（2012.01.31．大阪）, 2012, Peer-reviewed

  
• 霊長類パーキンソン病モデルにおけるヒトES 細胞由来神経細胞の腫瘍源性と機能

  土井大輔; 森実飛鳥; 高橋淳

  第15 回日本異種移植研究会（2012.12.8．京都）, 2012, Peer-reviewed

  
• iPS 細胞由来ドパミン神経細胞移植における生着向上因子の同定に向けて

  西村周泰; 高橋淳

  第35 回日本神経科学学会（2012.9.19．名古屋）, 2012, Peer-reviewed

  
• iPS 細胞を用いた脳内移植治療に対する生着向上因子の同定に向けて−ホスト脳環境の分子 基盤評価に基づいて−

  西村周泰; 高橋淳

  ブレインバンクセミナー（2012.08.21．東京）, 2012, Peer-reviewed

  
• パーキンソン病患者由来iPSC からのドーパミ ン神経誘導

  菊地哲広; 森実飛鳥; 土井大輔; 井上治久; 沖田圭介; 高橋淳

  第11 回日本再生医療学会総会（2012.06.13．横浜）, 2012, Peer-reviewed

  
• 臨床応用のためのヒト多能性幹細胞由来のドーパミン神経細胞純化方法の検討

  土井大輔; 菊地哲広; 森実飛鳥; 高橋淳

  第11 回日本再生医療学会総会（2012.06.12．横浜）, 2012, Peer-reviewed

  
• パーキンソン病に対する多能性幹細胞移植治療の開発研究

  高橋 淳

  ヒトES/iPS 細胞：産業応用最前線セミナー 〜細胞治療と創薬スクリーニング〜（2011 年12 月12 日 東京）, 2011, Peer-reviewed

  
• パーキンソン病に対する幹細胞移植治療

  高橋 淳

  堺市難病支援ネットワーク医療講演会（2011 年11 月19 日 堺）, 2011, Peer-reviewed

  
• 霊長類モデルを用いたパーキンソン病に対する幹細胞移植治療の前

  高橋 淳

  臨床研究 第7 回霊長類医学フォーラム（2011 年11 月18 日 つくば）, 2011, Peer-reviewed

  
• ES, iPS 細胞を用いた神経再生医療

  高橋 淳

  社団法人日本脳神経外科学会第70 回学術総会（2011 年10 月14 日 横浜）, 2011, Peer-reviewed

  
• パーキンソン病に対するES, iPS 細胞移植治療の開発

  高橋 淳

  第26 回神経組織の成長・再生・移植研究会学術 集会（2011 年6 月25 日 東京）, 2011, Peer-reviewed

  
• 幹細胞から分化誘導した中脳ドーパミン神経細胞の濃縮

  佐俣文平; 土井大輔; 尾野雄一; 高橋淳

  第10 回日本再生医療学会総会（2011.3.1 東京）, 2011, Peer-reviewed

  
• 神経前駆細胞脳内移植後の腫瘍化・過増大の制御におけるNotch inhibitor の有効性

  小倉 綾; 森実飛鳥; 中島悠介; 宮本享; 高橋淳

  第10 回日本再生医療学会総会 （2011.3.1-2 東京）, 2011, Peer-reviewed

  
• iPS 細胞由来ドパミン神経細胞移植におけるホスト脳環境の影響

  西村周泰; 高橋 淳

  第34 回日本神経科学大会（2011.9.17 横浜）, 2011, Peer-reviewed

  
• 表面抗原を用いたヒト多能性幹細胞由来のドーパミン神経細胞純化方法の検討

  土井大輔; 森実飛鳥; 菊地哲広; 吉川達也; 宮本 享; 高橋 淳

  第70 回日本脳神経外科学会総会（2011.10.12-14 横浜）, 2011, Peer-reviewed

  
• カニクイザルパーキンソン病 モデルへの ヒトES細胞由来ドーパミン神経細胞の移植 Transplantation of stem cell-derived dopaminergic neurons in primate brains

  森実飛鳥; 土井大輔; 菊地哲広; 吉川達也; 尾上浩隆; 林 拓也; 川崎俊之; 高橋 淳

  第70 回日本脳神経外科学会総会（2011.10.12 横浜）, 2011, Peer-reviewed

  
• ヒトES 細胞を用いたカニクイザルパーキンソ ン病モデルへの細胞移植

  森実飛鳥; 土井大輔; 菊地哲広; 吉川達也; 五味正憲; 高橋 淳

  第10 回 日本再生医療学会総会（2011.03.01 東京）, 2011, Peer-reviewed

  
• Host brain environment affects differentiation of the grafted iPSC-derived dopaminergic neurons

  Kaneyasu Nishimura; Jun Takahashi

  NEUROSCIENCE RESEARCH, 2011

  
• CHALLENGES TOWARDS ES CELL THERAPY FOR PARKINSON'S DISEASE

  J. Takahashi; A. Morizane; D. Dol; T. Kikuchi; H. Onoe; T. Hayashi

  JOURNAL OF NEUROCHEMISTRY, Oct. 2010

  
• 分子化合物を用いたヒト多能性幹細胞からの神経誘導

  森実飛鳥; 土井大輔; 菊地哲広; 高橋淳

  第9 回日本再 生医療学会総会（2010.3.18 広島）, 2010, Peer-reviewed

  
• iPS 細胞を用いたパーキンソン病治療

  高橋淳

  シンポジウム「iPS 細胞研究の最前線」（2010.10.2 東京）, 2010, Peer-reviewed

  
• パーキンソン病に対する幹細胞移植治療の開発研究

  高橋淳

  神経組織の成長・再生・移植研究会第25 回学術集会（2010.5.22 大阪）, 2010, Peer-reviewed

  
• パーキンソン病に対するiPS 細胞移植療法の開発研究

  高橋淳

  第47 回日本臨床分子医学会学術集会 （2010.4.10−11 東京）, 2010, Peer-reviewed

  
• パーキンソン病に対する細胞移植療法の開発

  高橋淳

  第9 回日本再生医療学会総会（2010.3.18 広島）, 2010, Peer-reviewed

  
• 霊長類モデルを用いたパーキンソン病に対する幹細胞移植治療開発研究

  高橋淳

  第2 回滋賀医科大学サルシンポジウム（2010.2.22 滋賀）, 2010, Peer-reviewed

  
• パーキンソン病モデルサルに対するヒトiPS 細胞由来ドーパミン神経移植

  菊地哲広; 森実飛鳥; 土井大輔; 尾上浩隆; 林拓也; 川崎俊之; 宮本享; 高橋淳

  社団法人日本脳神経外科学会第69 回学術総会 （2010.10.27−29．福岡）, 2010, Peer-reviewed

  
• 浮遊培養法によるヒトES 及びiPS 細胞からの神経分化誘導

  菊地哲広; 森実飛鳥; 土井大輔; 高橋淳

  第9 回 日本再生医療学会総会（2010.3.18−19．広島）, 2010, Peer-reviewed

  
• ヒトES 細胞由来の神経細胞移植における霊長類パーキンソン病モデルでの腫瘍形成

  土井大輔; 菊地哲広; 森実飛鳥; 高橋淳

  第4 回パーキンソン病・運動障害疾患コングレス（2010.10.8 京都）, 2010, Peer-reviewed

  
• 霊長類パーキンソン病モデルに対するヒトES 細胞由来移 植片の腫瘍源性

  土井大輔; 菊地哲広; 森実飛鳥; 斎木英資; 高橋淳

  第9 回日本再生医療学会総会（2010.3.18−19 広島）, 2010, Peer-reviewed

  
• サルiPS 細胞からのドーパミン神経分化誘導

  森実飛鳥; 菊地哲広; 吉川達也; 土井大輔; 高橋淳

  神経組織の成長・再生・移植研究会第25 回学術集会（2010.5.22 大阪）, 2010, Peer-reviewed

  
• パーキンソン病に対するGDNF 徐放化生体吸収性ハイドロゲル脳内移植の効果

  吉川達也; 小原洋志; 田畑泰彦; 高橋淳

  第9 回日本再生医療学会（2010.3.19 広島）, 2010, Peer-reviewed

  
• ES，iPS 細胞を用いたパーキンソン病治療の展望

  高橋淳

  「第38 回さいたま市神経カンファレンス学術講演会」 （2009.11.17．埼玉）, 2009, Peer-reviewed

  
• 多能性幹細胞移植によるパーキンソン病治療の現状と展望

  高橋淳

  「第14 回東北パーキンソン病治療研究会」 （2009.11.14．仙台）, 2009, Peer-reviewed

  
• ヒトES 細胞移植における腫瘍形成能の検討

  高橋淳

  「第32 回日本神経科学大会Neuroscience2009」（2009.9.16． 名古屋）, 2009, Peer-reviewed

  
• ES，iPS 細胞を用いたパーキンソン病治療開発研究の現状と展望

  高橋淳

  2009, Peer-reviewed

  
• 細胞移植による神経再生の将来

  高橋淳

  「第50 回日本神経学会総会」（2009.5.21．仙台）, 2009, Peer-reviewed

  
• ES細胞，iPS細胞を用いたパーキンソン病治療へ向けての現状と展望

  高橋淳

  「第5 回長崎ニューロサイエン ス研究会」（2009.5.23．長崎）, 2009, Peer-reviewed

  
• ES細胞研究と臨床への期待

  高橋淳

  「第29 回日本脳神経外科コングレス総会」（2009.5.15．大阪）, 2009, Peer-reviewed

  
• 細胞移植による神経再生

  高橋淳

  「日本医工学治療学会第25 回学術大会」（2009.4.12．大阪）, 2009, Peer-reviewed

  
• ES細胞移植によるパーキンソン病治療法の開発

  高橋淳

  「第6回大阪ニューロサイエンスクラブ」（2009.3.27． 大阪）, 2009, Peer-reviewed

  
• ES細胞を用いたパーキンソン病治療の開発〜再生医療の今と未来〜

  高橋淳

  「平成20 年度奈良市医師会学術 講演会」（2009.3.21．奈良）, 2009, Peer-reviewed

  
• パーキンソン病に対する細胞移植治療の現状と展望

  高橋淳

  「パーキンソン病基礎と臨床の最前線シンポジ ウム」（2009.3.7．京都）, 2009, Peer-reviewed

  
• 幹細胞脳内移植におけるバイオマトリクス

  高橋淳

  「再生医科学研究所医工学フォーラム」（2009.2.25．京都）, 2009, Peer-reviewed

  
• ES，iPS 細胞移植によるパーキンソン病治療へ向けての試み

  高橋淳

  「第6 回神奈川ニューロサイエンスセミ ナー」（2009.1.30．横浜）, 2009, Peer-reviewed

  
• バイオマトリックスを用いた神経細胞移植

  吉川達也; 滝和郎; 宮本享; 高橋淳

  第68回日本脳神経外科学会学術総会（2009.10.14．東京）, 2009, Peer-reviewed

  
• 浮遊培養法によるヒトiPS細胞からの神経分化誘導

  菊地哲広; 森実飛鳥; 土井大輔; 宮本享; 高橋淳

  日本脳神経外科学会第68 回学術総会（2009.10.14−16．東京）, 2009, Peer-reviewed

  
• 浮遊培養法によるiPS 細胞からの神経分化誘導

  菊地哲広; 森実飛鳥; 土井大輔; 高橋淳

  神経組織の成長・再生・移植研究会第24 回学術集会（2009.6.21．渋川市）, 2009, Peer-reviewed

  
• マウス慢性脳低灌流モデルに対する 血管前駆細胞移植の効果

  鷲田和夫; 猪原匡史; 高橋淳; 山下潤; 伊東秀文; 冨本秀和; 高橋良輔

  日本神経科学大会（2009.9.16．名古屋）, 2009, Peer-reviewed

  
• マウス局所脳虚血モデルへのES細胞由来神経幹細胞移植におけるAnti -interleukin-6 receptor antibodyの効果

  五味正憲; 高橋淳; 丸茂岳; 高木康志

  第34 回日本脳卒中学会（2009.3.22．松江）, 2009, Peer-reviewed

  
• ヒトES 細胞由来の神経細胞移植における腫瘍形成とその回避

  土井大輔; 菊地哲広; 林英樹; 森実飛鳥; 宮本享; 高橋淳

  日本脳神経外科学会（2009.10.14．東京）, 2009, Peer-reviewed

  
• ヒト多能性幹細胞からの神経誘導におけるNodal/BMP抑制の役割

  森実飛鳥; 土井大輔; 菊地哲広; 宮本享; 高橋淳

  第68回日本脳神経外科学会学術総会（2009.10.14−17．東京）, 2009, Peer-reviewed

  
• 増殖可能なドーパミン神経前駆細胞のヒトES 細胞からの誘導

  森実飛鳥; 高橋淳; Jia-Yi Li; Patrik Brundin

  第8回日本再生医療学会総会（2009.3.5−6．東京）, 2009, Peer-reviewed

  
• 頚動脈内膜剥離術後の急性閉塞に対して,血栓除去とステント留置による再開通で完全回復した一例

  石井暁; 荒川芳輝; 中江卓郎; 西村真樹; 高橋淳; 高木康志; 宮本享

  Journal of Neuroendovascular Therapy, 2009

  
• Tumor formation in cell replacement therapy using human ES cells

  Jun Takahashi; Daisuke Doi; Asuka Morizane

  NEUROSCIENCE RESEARCH, 2009

  
• 再生医療の臨床応用に向けて

  高橋淳

  神戸医療産業都市構想10周年記念事業, 2008, Peer-reviewed

  
• PET 分子イメージングと再生医療

  高橋淳

  PET 科学アカデミーセミナー（2008.10.28．神戸）, 2008, Peer-reviewed

  
• 多能性幹細胞からのドーパミン産生神経誘導と移植

  高橋淳

  第29回神経組織培養研究会（2008.9.20．東京）, 2008, Peer-reviewed

  
• ES 細胞を用いたパーキンソン病治療の開発

  高橋淳

  第34回神戸薬科大学卒後教育講座（2008.9.7．神戸）, 2008, Peer-reviewed

  
• iPS 細胞を用いたパーキンソン病に対する移植治療の実現化

  高橋淳

  再生医療の実現化プロジェクト第１回 夏のワークショップ（2008.8.28．熱海）, 2008, Peer-reviewed

  
• ここまで進んだパーキンソン病の治療〜ES 細胞を利用した治療方法〜

  高橋淳

  関西広域バイオメディカルク ラスター成果発表会（2008.3.20．大阪）, 2008, Peer-reviewed

  
• ES 細胞由来神経前駆細胞の脳内移植における腫瘍形成と炎症・免疫反応

  高橋淳

  第７回日本再生医療学会総 会（2008.3.13-14．横浜）, 2008, Peer-reviewed

  
• パーキンソン病治療

  高橋淳

  関西広域バイオメディカルクラスター再生医療の実現化セミナー（2008.2.21． 東京）, 2008, Peer-reviewed

  
• ES 細胞を利用した神経再生医療

  高橋淳

  再生医科学研究所医工学フォーラム（2008.2.20．京都）, 2008, Peer-reviewed

  
• Matrix を用いた細胞移植療法の開発

  植村真; Mohamed Refaat; 高橋淳

  神経組織の成長・再生・移植研究 会第23回学術集会（2008.5.17．幕張）, 2008, Peer-reviewed

  
• Interleukin-6 のES 細胞由来神経幹細胞の分化・遊走に対する影響

  五味正憲; 篠山瑞也; 高橋淳

  第９回日本 分子脳神経外科学会（2008.8.30-31．京都）, 2008, Peer-reviewed

  
• 霊長類パーキンソン病モデルに対す るヒトES 細胞移植

  土井大輔; 菊地哲広; 斎木英資; 尾上浩隆; 林拓也; 林英樹; 高橋淳

  神経組織の成長・再生・移植研究会第23回学術集会（2008.5.17．幕張）, 2008, Peer-reviewed

  
• Wnt シグナルを利用したES 細胞からの神経誘導法の開発

  林英樹; 土井大輔; 高橋淳

  第67回日本脳神経 外科学会（2008.10.1-3．盛岡）, 2008, Peer-reviewed

  
• ヒトES 細胞の継代培養数と脳内移植後の生着について

  森実飛鳥; 高橋淳; Jia-Yi Li; Patrik Brundin

  第67回 日本脳神経外科学会（2008.10.1-3．盛岡）, 2008, Peer-reviewed

  
• Meningeal cells induce dopaminergic neurons from embryonic stem cells

  Jun Takahashi; Hideki Hayashi; Asuka Morizane

  NEUROSCIENCE RESEARCH, 2008

  
• 脳深部刺激療法（DBS）について

  高橋淳

  京丹後・舞鶴地区脳深部刺激療法（DBS）座談会（2007.2.1．舞鶴）, 2007, Peer-reviewed

  
• ES 細胞移植によるパーキンソン病治療の開発

  高橋淳

  京都大学再生医科学研究所平成19 年度学術講演会 （2007.12.26．京都）, 2007, Peer-reviewed

  
• 再生医療における分子イメージングの有用性

  高橋淳

  PET 科学アカデミーセミナー（2007.11.21．神戸）, 2007, Peer-reviewed

  
• ES 細胞を利用した神経再生

  高橋淳

  第28 回滋賀神経疾患研究会学術研修会（2007.10.27．草津）, 2007, Peer-reviewed

  
• ES 細胞を用いた神経再生医療

  高橋淳

  第54 回日本麻酔科学会学術集会（2007.5.31−6.2．札幌）, 2007, Peer-reviewed

  
• ES 細胞利用によるパーキンソン病治療法の開発

  高橋淳

  第22 回神経組織の成長・再生・移植研究会 （2007.5.25−26．岡山）, 2007, Peer-reviewed

  
• ES 細胞を用いたパーキンソン病治療開発

  高橋淳

  第5 回京大臨床心血管再生研究会シンポジウム（2007.3.6．京都）, 2007, Peer-reviewed

  
• パーキンソン病に対するニューロモデュレーション

  高橋淳

  第11 回京都内科神経懇話会（2007.3.3．京都）, 2007, Peer-reviewed

  
• ES細胞由来神経前駆細胞のanoikisとRho情報伝達系

  小柳正臣; 高橋淳; 森実飛鳥; 荒川芳輝; 岡本洋; 福田仁; 林英樹; 橋本信夫

  再生医療, 2005

  

Industrial Property Rights

• 特開WO2017/183736, 特願2018-513238, ドーパミン産生神経前駆細胞の製造方法

  高橋淳; 土井大輔; 吉田賢司; 桑原篤; 高橋政代

  
• 特開WO2019/031595, 特願PCT/JP2018/029999, 神経前駆細胞の選別方法

  Jun Takahashi; Asuka Morizane; Tadashi Sunohara; Hirohide Saito; Parr Callum; Moe Yokoshi

  
• 特開WO2016/167372, 特願2017-512611, 大脳皮質ニューロンの誘導方法

  高橋淳; 元野誠; 五百蔵義彦

  
• 特開WO2017/183736, 特願PCT/JP2017/016246, ドーパミン産生神経前駆細胞の製造方法

  Jun Takahashi; Daisuke Doi; Kenji Yoshida; Atsushi Kuwahara; Masayo Takahashi

  
• 特開WO2015/034012, 特願2015-535520, 新規ドーパミン産生神経前駆細胞の誘導方法

  高橋淳; 土井大輔; 佐俣文平; 関口清俊; 尾野雄一

  
• 特許6090937, 特開特表2014-523734, 特願2014-502915, 新規ドーパミン産生神経前駆細胞マーカー

  高橋淳; 土井大輔; 佐俣文平; 尾野雄一

  
• 特開2017-35080, 特願2016-158111, 細胞搬送用容器

  高橋淳; 土井大輔; 岡本恭典; 田中聖真

  
• 特開2017-35079, 特願2016-158110, マイクロチューブ、細胞収容回収器具セット、及び細胞回収補助具

  高橋淳; 土井大輔; 岡本恭典; 田中聖真

  
• 特開WO2016/167372, 特願PCT/JP2016/062578, METHOD FOR INDUCING CEREBRAL CORTEX NEURONS

  Jun Takahashi; Makoto Motono; Yoshihiko Ioroi

  
• 特許5761816, 特開特表2013-501502, 特願2012-507516, 多能性幹細胞から神経前駆細胞への分化誘導法

  高橋淳; 森実飛鳥

  
• 特開WO2015/034012, 特願PCT/JP2014/073372, 新規ドーパミン産生神経前駆細胞の誘導方法

  Jun Takahashi; Daisuke Doi; Bumpei Samata; Kiyotoshi Sekiguchi; Yuuichi Ono

  
• 特開WO2013/015457, 特願PCT/JP2012/069785, NOVEL MARKERS FOR DOPAMINERGIC NEURON PROGENITOR CELLS

  Jun Takahashi; Daisuke Doi; Bumpei Samata; Yuuichi Ono

  
• 特開WO2011/019092, 特願PCT/JP2010/063953, METHOD FOR INDUCING DIFFERENTIATION OF PLURIPOTENT STEM CELLS INTO NEURAL PRECURSOR CELLS

  Jun Takahashi; Asuka Morizane

  

External funds: Kakenhi

• Identification of molecular mechanisms of RNF213-related occlusive cerebrovascular diseases and development of new treatment strategies

  Grant-in-Aid for Scientific Research (B)

  Basic Section 56010:Neurosurgery-related

  Kyoto University

  Susumu Miyamoto

  From 01 Apr. 2019, To 31 Mar. 2022, Project Closed

  moyamoya;genetics;iPS cells;cerebrovascular disease;atherosclerosis;moyamoya disease;RNF213;iPS;gene editing;閉塞性血管障害;遺伝子変異;血管平滑筋細胞;血管内皮細胞;もやもや病;感受性遺伝子;iPSモデル;遺伝子改変マウス;CFD

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03770/
• Reconstruction of cerebrospinal pathway using iPS cells

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Jun TAKAHASHI

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  神経再生;再生医学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H04302/
• Identification of modifiers of moyamoya disease causing gene RNF213 and development of in vitro and in vivo models of the disease

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Susumu Miyamoto

  From 01 Apr. 2016, To 31 Mar. 2019, Project Closed

  脳血管障害;もやもや病;RNF213;脳血管障害学;脳卒中

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H05437/
• Transplantation of iPS cell-derived neuronal stem cells into ischemic brain

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Yasushi Takagi

  From 01 Apr. 2013, To 31 Mar. 2017, Project Closed

  脳血管障害学;脳梗塞;再生医療;移植治療;胚性幹細胞;骨髄間質細胞;神経幹細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293308/
• iPS細胞を用いた皮質脊髄路再構築による運動機能再生

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  高橋 淳

  From 01 Apr. 2013, To 31 Mar. 2014, Declined

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25293307/
• Improving safety in neural celltransplantation with human inducedpluripotent stem cells

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Asuka MORIZANE

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  パーキンソン病;腫瘍化;神経;多能性幹細胞;ソーティング;ドーパミン;移植;iPS細胞;分化誘導;ドーパミン神経;神経幹細胞;細胞移植;低分子化合物

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591837/
• Optimization of the host brain environment for the cell replacement therapy using ES cells

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Jun TAKAHASHI

  From 01 Apr. 2008, To 31 Mar. 2011, Project Closed

  実験脳外科学;ES細胞;神経分化;細胞移植;炎症

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390383/
• Stroke therapy using embryonic stem cells and bone marrow stromal cell-derived neuralstem cells

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Yasushi TAKAGI

  From 01 Apr. 2008, To 31 Mar. 2012, Project Closed

  脳梗塞;神経幹細胞;骨髄間質細胞;胚性幹細胞;移植;ES細胞;iPS細胞;脳虚血;移植治療;脳血管障害学;神経幹細胞移植

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390382/
• Cellular and molecular trafficking of transplanted cell into central nervous system by magnetic resonance unit

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Kenichiro KIKUTA

  From 01 Apr. 2006, To 31 Mar. 2009, Project Closed

  細胞分子イメージング;細胞移植治療;脳虚血;頚動脈狭窄;内皮前駆細胞;骨髄

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390399/
• 髄膜とPA6との比較検討によるドーパミン産生神経誘導能の解明

  Grant-in-Aid for Exploratory Research

  Kyoto University

  高橋 淳

  From 01 Apr. 2005, To 31 Mar. 2007, Project Closed

  ES細胞;神経誘導;ドーパミン産生神経

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17659442/
• Induction of dopaminergic neurons from human ES cells, and transplantation of the cells into monkey Parkinson's disease models

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Jun TAKAHASHI

  From 01 Apr. 2005, To 31 Mar. 2008, Project Closed

  ES細胞;神経分化誘導;細胞移植;パーキンソン病;ドーパミン産生神経;腫瘍形成;ヒトES細胞;神経細胞移植, embryonic stem cells;neural induction;cell transplantation;Parkinson's disease;dopaminergic neuron;tumor formation

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17390397/
• 幹細胞生存支持活性があり増殖活性は無いサイトカインSDNSFによる生体防御の解析

  Grant-in-Aid for Exploratory Research

  Kyoto Prefectural University of Medicine

  田代 啓

  From 01 Apr. 2004, To 31 Mar. 2005, Project Closed

  神経幹細胞;分泌タンパク質;シグナルシークエンストラップ;未分化;サイトカイン;生存支持;ラット;海馬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16659084/
• サイトカインSDNSFの放射線治療における幹細胞生存支持能のマウスモデルでの解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto Prefectural University of Medicine

  田代 啓

  From 01 Apr. 2004, To 31 Mar. 2005, Project Closed

  神経幹細胞;分泌タンパク質;シグナルシークエンストラップ;未分化;サイトカイン;生存支持;ラット;海馬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16023233/
• Transplantation of monkey ES cell-derived dopaminergic neurons into the brain of MPTP-treated monkey

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Jun TAKAHASHI

  From 01 Apr. 2002, To 31 Mar. 2005, Project Closed

  ES細胞;細胞移植;パーキンソン病;ドーパミン産生神経;ドーパミン産生ニューロン;ドーパミン作動性ニューロン, ES cell;Cell Transplantation;Parkinson's disease;Dopaminergic neuron

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14370431/
• Isolation and characterization of stem cell-derived neural stem/progenitor cell supporting factor, SDNSF.

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Kei TASHIRO

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  神経幹細胞;分泌タンパク質;シグナルシークエンストラップ;未分化;サイトカイン;生存支持;ラット;海馬;生存支持因子;幹細胞由来神経生存因子;SDNSF;分泌タンパク;カルシウム依存性;遺伝子欠損マウス;細胞生存支持活性;MTTアッセイ;タンパク精製;ポリクローナル抗体;細胞増殖因子, stem cell;inner ear;secreted molecule;signal-sequence trap;otocyst;soluble factor;rat;development

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13470036/
• ヒト神経幹細胞の解析によるニューロン分化機構の解明

  Grant-in-Aid for Scientific Research on Priority Areas (C)

  Biological Sciences

  Kyoto University

  高橋 政代

  From 01 Apr. 2001, To 31 Mar. 2002, Project Closed

  神経幹細胞;ヒト胎児脳;ヒト胎児網膜;成人虹彩;視細胞;ホメオボックス遺伝子;組織特異性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13210077/
• 新たなHIV-1ウイルス感染標的細胞としてのヒト脳由来神経系幹細胞の解析

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Biological Sciences

  Kyoto University

  田代 啓

  From 01 Apr. 2001, To 31 Mar. 2002, Project Closed

  HIVウイルス;エイズ脳症;脳神経;ウイルス受容体;神経幹細胞;標的細胞;CXCR4;CCR5

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13015209/
• Regeneration of neuronal function by grafting neural stem cells

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Jun TAKAHASHI

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  神経幹細胞;てんかん;一過性脳虚血;移植;cortical dysplasia;ニューロン, Neural Stem Cells;Epilepsy;Transient Ischemia;Transplantation;Cortical Dysplasia;Neuron

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12671354/
• ヒト神経幹細胞のクローン解析によるニューロン分化機構の解明

  Grant-in-Aid for Scientific Research on Priority Areas (C)

  Biological Sciences

  Kyoto University

  高橋 政代

  From 01 Apr. 2000, To 31 Mar. 2001, Project Closed

  ヒト;塩基性線維芽細胞成長因子;上皮細胞成長因子;脳;網膜;虹彩色素上皮;神経幹細胞;培養

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12210087/
• ヒト脳由来神経系幹細胞株の分化誘導系によるHIVウイルス標的細胞の同定

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Biological Sciences

  Kyoto University

  田代 啓

  From 01 Apr. 2000, To 31 Mar. 2001, Project Closed

  エイズ脳症;HIV;ニューロエイズ;神経幹細胞;エイズ;ウイルス受容体;感染実験;productive infection

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12035213/
• 神経系幹細胞の自己複製因子および特異的表面マーカーの同定

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Kyoto University

  高橋 淳

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  神経幹細胞;分化;海馬;クローニング;シグナルシークエンストラップ;神経系幹細胞;ラット;神経誘導;神経突起

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10770678/
• Functions of IL-1B in preclinical models of RNF213-related angiopathy

  Grant-in-Aid for Scientific Research (B)

  Basic Section 56010:Neurosurgery-related

  Kyoto University

  宮本 享

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  moyamoya;RNF213;iPS;mouse model;inflammation;chronic inflammation

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H03185/
• Elucidation of the role of IL-1beta in RNF213-related vascular disorders and development of preclinical models

  Grant-in-Aid for Scientific Research (B)

  Basic Section 56010:Neurosurgery-related

  Kyoto University

  宮本 享

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  moyamoya disease;RNF213;IL-1beta;moyamoya;iPS;mouse model;inflammation;chronic inflammation

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K24444/

Education

Teaching subject(s)

• From Apr. 2011, To Mar. 2012

  Intoroduction to Biomedical Engineering

  Spring, 全学共通科目
• From Apr. 2011, To Mar. 2012

  Seminar on developmental biology and regenerative medicine

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Introduction to Biomedical Engineering

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Seminar on developmental biology and regenerative medicine

  Spring, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Seminar on Developmental Biology and Regenerative Medicine

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Seminar on Developmental Biology and Regenerative Medicine

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Seminar on Developmental Biology and Regenerative Medicine

  Spring, 全学共通科目

Participation in PhD Defense

• Identifying and reverting the adverse effects of white matter hyperintensities on cortical surface analyses

  OI YUKI, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Evaluation of Foveal Cone and M■ller Cells in Epiretinal Membrane using Adaptive Optics OCT

  ISHIKURA MASAHARU, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Evaluation of BCAS1-positive immature oligodendrocytes after cerebral ischemic stroke and SVD

  JIANG GUANHUA, Graduate School of Medicine, Chief Examiner

  23 Jan. 2024
• Motor Progression and Nigrostriatal Neurodegeneration in Parkinson Disease

  FURUKAWA KOJI, Graduate School of Medicine, Sub-chief Examiner

  23 May 2023
• A model for estimating the brainstem volume in normal healthy individuals and its application to diffuse axonal injury patients

  FUJIMOTO GAKU, Graduate School of Medicine, Sub-chief Examiner

  23 May 2023
• Acute inhibition of AMPA receptors by perampanel reduces amyloid β-protein levels by suppressing β-cleavage of APP in Alzheimer’s disease models

  UEDA SAKIHO, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Altered functional connectivity associated with striatal dopamine depletion in Parkinson’s disease

  SHIMA ATSUSHI, Graduate School of Medicine, Sub-chief Examiner

  25 Sep. 2023
• Microglia-triggered hypoexcitability plasticity of pyramidal neurons in the rat medial prefrontal cortex

  YAMAWAKI YUKI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Long-Term Outcome of Sciatic Nerve Regeneration Using　Bio3D Conduit Fabricated from Human Fibroblasts in a Rat Sciatic Nerve Model

  ANDO MAKI, Graduate School of Medicine, Chief Examiner

  23 Mar. 2023
• Rapid induction of dopaminergic neuron loss accompanied by Lewy body-like inclusions in A53T BAC-SNCA transgenic mice

  OKUDA SHINYA, Graduate School of Medicine, Sub-chief Examiner

  23 May 2022
• Enhanced phase-amplitude coupling of human electrocorticography selectively in the posterior cortical region during rapid eye movement sleep

  TOGAWA JUMPEI, Graduate School of Medicine, Sub-chief Examiner

  24 Nov. 2022
• Long-term Effect of Regular Physical Activity and Exercise Habits in Patients With Early Parkinson Disease

  TSUKITA KAZUTO, Graduate School of Medicine, Chief Examiner

  23 Mar. 2022
• A Biomarker for Benign Adult Familial Myoclonus Epilepsy: High-Frequency Activities in Giant Somatosensory Evoked Potentials

  TOJIMA MAYA, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• Sonic hedgehog expands neural stem cells in the neocortical region leading to an expanded and wrinkled neocortical surface

  MOHAMMED J.M. SHQIRAT, Graduate School of Medicine, Sub-chief Examiner

  24 Sep. 2021
• Hes1 oscillation frequency correlates with activation of neural stem cells

  KAISE TAKASHI, Graduate School of Medicine, Sub-chief Examiner

  26 Jul. 2021
• CD146 is a potential immunotarget for neuroblastoma

  OHBU SATOSHI, Graduate School of Medicine, Chief Examiner

  23 Mar. 2022
• Overlapping Projections of Neighboring Direct and Indirect Pathway Neostriatal Neurons to Globus Pallidus External Segment

  OKAMOTO SHINICHIRO, Graduate School of Medicine, Sub-chief Examiner

  24 Nov. 2021
• Impact of Intraoperative 3-Tesla MRI on Endonasal Endoscopic Pituitary Adenoma Resection and a Proposed New Scoring System for Predicting the Utility of Intraoperative MRI

  TANJI MASAHIRO, Graduate School of Medicine, Chief Examiner

  24 May 2021
• Impact of Gba2 on neuronopathic Gaucher’s disease and α-synuclein accumulation in medaka (Oryzias latipes)

  NAKANISHI　ETSURO, Graduate School of Medicine, Chief Examiner

  24 Jan. 2022

Administration

School management (title, position)

• From 01 Jul. 2022, To 31 Mar. 2024

  ｉＰＳ細胞学系 学系長
• From 01 Jul. 2022, To 31 Mar. 2024

  ｉＰＳ細胞研究所 所長
• From 01 Apr. 2024, To 31 Mar. 2026

  教育研究評議会 評議員
• From 01 Apr. 2024, To 31 Mar. 2026

  部局長会議
• From 01 Apr. 2024, To 31 Mar. 2026

  利益相反マネジメント委員会 委員
• From 01 Apr. 2024, To 31 Mar. 2026

  全学情報セキュリティ委員会 委員
• From 01 Apr. 2024, To 31 Mar. 2026

  人事審査委員会 委員
• From 01 Apr. 2022, To 31 Mar. 2024

  京都大学利益相反マネジメント委員会
• From 01 Apr. 2022

  研究連携基盤運営委員会
• From 01 Apr. 2022, To 31 Mar. 2024

  全学情報セキュリティ委員会 委員
• From 01 Apr. 2022

  研究公正委員会 委員
• From 01 Apr. 2022, To 30 Jun. 2022

  人事審査委員会 委員
• From 01 Apr. 2022, To 31 Mar. 2024

  部局長会議
• From 01 Apr. 2022, To 31 Mar. 2024

  教育研究評議会 評議員
• From 01 Apr. 2022, To 30 Jun. 2022

  ｉＰＳ細胞学系 学系長
• From 01 Apr. 2022, To 30 Jun. 2022

  ｉＰＳ細胞研究所 所長
• From 11 Sep. 2009, To 10 Sep. 2013

  京都大学ヒトゲノム・遺伝子解析研究管理委員会 委員
• From 11 Sep. 2011, To 10 Sep. 2013

  京都大学ヒトゲノム・遺伝子解析研究管理委員会 委員
• From 11 Sep. 2013, To 10 Sep. 2015

  ヒトゲノム・遺伝子解析研究管理委員会 委員
• From 11 Sep. 2015, To 31 Dec. 2015

  ヒトゲノム・遺伝子解析研究管理委員会 委員

Faculty management (title, position)

• From 01 Apr. 2022

  放射線障害防止委員会
• From 01 Apr. 2022

  情報管理委員会
• From 01 Apr. 2022

  教員業績評価委員会
• From 01 May 2014, To 31 Mar. 2016

  副所長
• From 01 Apr. 2018, To 31 Mar. 2022

  副所長
• From 01 May 2014, To 31 Mar. 2016

  管理運営委員会2号委員
• From 01 Apr. 2018

  管理運営委員会2号委員
• From 01 May 2014, To 31 Mar. 2016

  利益相反審査委員会2号委員
• From 01 Apr. 2018, To 31 Mar. 2020

  利益相反審査委員会2号委員
• From 01 Apr. 2014

  動物実験委員会2号委員
• From 01 Apr. 2014, To 31 Mar. 2018

  京都大学再生医科学研究所、物質-細胞統合システム拠点及びiPS細胞研究所 合同医の倫理委員会
• From 01 Apr. 2018, To 31 Mar. 2022

  京都大学ウイルス・再生医科学研究所医の倫理委員会
• From 09 Sep. 2015, To 31 Mar. 2017

  物質-細胞統合システム拠点ヒトES細胞研究倫理審査委員会委員
• 臨床応用研究部門長
• 教員表彰選考委員会2号委員
• From 01 Apr. 2020

  財務委員会委員長、1号委員
• From 01 Apr. 2016, To 31 Mar. 2022

  人権委員会委員長、1号委員
• From 06 Jun. 2019

  自己点検・評価委員会1号、2号委員