Basic Information

Faculty

• Faculty of Medicine

Email Address

• Email Address

  yanatori.izumi.8nkyoto-u.ac.jp

Academic Degree

• 14 Mar. 2013

  川崎医科大学博士（医学）

Academic Resume (Undergraduate School/Majors)

• 鹿児島大学, 歯学部歯学科, 卒業

Research History

• From Jun. 2023, To Present

  Kyoto University, Department of Molecular and Cellular Physiology Graduate School of Medicine, 講師
• From Apr. 2023, To May 2023

  Kyoto University, 細胞機能制御学, Program-Specific Senior Lecturer
• From Apr. 2021, To Mar. 2023

  Kyoto University, 細胞機能制御学, 特定助教
• From Apr. 2019, To Mar. 2021

  Nagoya University, Graduate School of Medicine, 特任助教
• From Jun. 2017, To Mar. 2019

  Stanford University School of Medicine, Biochemistry, Postdoctoral research
• From Apr. 2017, To May 2017

  Nagoya University, Graduate School of Medicine, 研究員
• From Apr. 2013, To Mar. 2017

  Kawasaki Medical School, 分子生物学, 講師
• From Apr. 2007, To Mar. 2013

  Kawasaki Medical School, 分子生物学, 助教

ID,URL

• J-Global ID

  201901012097657339

researchmap URL

• https://researchmap.jp/izumiyanatori

Research

Research Interests

• フェロトーシス
• 老化
• 鉄シャペロン
• エフェクター分子
• クラミジア
• 感染症
• 酸化ストレス
• 鉄代謝

Research Areas

• Life sciences, Cell biology
• Life sciences, Molecular biology
• Life sciences, Bacteriology, クラミジア、エフェクター分子
• Life sciences, Medical biochemistry

Papers

• Iron metabolism and ferroptosis

  Shinya Toyokuni; Izumi Yanatori

  Ferroptosis in Health and Disease, 10 Oct. 2019

  
• 細胞内鉄輸送タンパク質PCBP1における鉄イオンの結合と輸送の分子メカニズム

  浦 敦人; 簗取 いずみ; 城 宜嗣; 澤井 仁美

  日本生化学会大会プログラム・講演要旨集, Nov. 2022

  
• Association of poly(rC)-binding protein-2 with sideroflexin-3 through TOM20 as an iron entry pathway to mitochondria.

  Danyang Mi; Izumi Yanatori; Hao Zheng; Yingyi Kong; Tasuku Hirayama; Shinya Toyokuni

  Free radical research, 10 Apr. 2024, Peer-reviewed

  
• Protocol for the isolation of GFP-expressing ferroptosis-dependent extracellular vesicles in in vitro cell culture models.

  Fumiya Ito; Izumi Yanatori; Katsuhiro Kato; Shinya Toyokuni

  STAR protocols, 15 Mar. 2024, Peer-reviewed, Invited

  
• New iron export pathways acting via holo-ferritin secretion.

  Izumi Yanatori; Fumio Kishi; Shinya Toyokuni

  Archives of biochemistry and biophysics, 06 Sep. 2023, Peer-reviewed, Invited, Lead author, Corresponding author

  
• Iron links endogenous and exogenous nanoparticles.

  Shinya Toyokuni; Yingyi Kong; Misako Katabuchi; Yuki Maeda; Yashiro Motooka; Fumiya Ito; Izumi Yanatori

  Archives of biochemistry and biophysics, 01 Sep. 2023, Peer-reviewed, Invited

  
• Newly uncovered biochemical and functional aspects of ferritin.

  Izumi Yanatori; Sohji Nishina; Fumio Kishi; Keisuke Hino

  FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Aug. 2023, Peer-reviewed, Lead author

  
• Matrigel-based organoid culture of malignant mesothelioma reproduces cisplatin sensitivity through CTR1.

  Fumiya Ito; Katsuhiro Kato; Izumi Yanatori; Yuki Maeda; Toyoaki Murohara; Shinya Toyokuni

  BMC cancer, 31 May 2023, Peer-reviewed

  
• Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin.

  Fumiya Ito; Katsuhiro Kato; Izumi Yanatori; Toyoaki Murohara; Shinya Toyokuni

  Redox biology, Nov. 2021, Peer-reviewed

  
• Iron and liver cancer: an inseparable connection.

  Keisuke Hino; Izumi Yanatori; Yuichi Hara; Sohji Nishina

  The FEBS journal, 20 Sep. 2021, Peer-reviewed, Invited

  
• CD63 is regulated by iron via the IRE-IRP system and is important for ferritin secretion by extracellular vesicles.

  Izumi Yanatori; Des R Richardson; Herschel S Dhekne; Shinya Toyokuni; Fumio Kishi

  Blood, 21 Oct. 2021, Peer-reviewed, Lead author

  
• LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade.

  Herschel S Dhekne*; Izumi Yanatori*(*equally contributed); Edmundo G Vides; Yuriko Sobu; Federico Diez; Francesca Tonelli; Suzanne R Pfeffer

  Life science alliance, May 2021, Peer-reviewed, Lead author

  
• Application of a C. trachomatis expression system to identify C. pneumoniae proteins translocated into host cells.

  Izumi Yanatori; Koshiro Miura; Yi-Shan Chen; Raphael H Valdivia; Fumio Kishi

  Journal of bacteriology, 08 Mar. 2021, Peer-reviewed, Lead author

  
• Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering.

  Shinya Toyokuni; Yingyi Kong; Zhen Cheng; Kotaro Sato; Shotaro Hayashi; Fumiya Ito; Li Jiang; Izumi Yanatori; Yasumasa Okazaki; Shinya Akatsuka

  Cancers, 10 Nov. 2020, Peer-reviewed

  
• Iron loss triggers mitophagy through induction of mitochondrial ferritin.

  Yuichi Hara; Izumi Yanatori; Atsushi Tanaka; Fumio Kishi; John J Lemasters; Sohji Nishina; Kyo Sasaki; Keisuke Hino

  EMBO reports, 05 Nov. 2020, Peer-reviewed

  
• The new role of poly (rC)-binding proteins as iron transport chaperones: Proteins that could couple with inter-organelle interactions to safely traffic iron.

  Izumi Yanatori; Des R Richardson; Shinya Toyokuni; Fumio Kishi

  Biochimica et biophysica acta. General subjects, Nov. 2020, Peer-reviewed, Lead author

  
• Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium.

  Fumiya Ito; Izumi Yanatori; Yuki Maeda; Kenta Nimura; Satoki Ito; Tasuku Hirayama; Hideko Nagasawa; Norihiko Kohyama; Yasumasa Okazaki; Shinya Akatsuka; Shinya Toyokuni

  Redox biology, Sep. 2020, Peer-reviewed

  
• Ferroptosis at the crossroads of infection, aging and cancer.

  Shinya Toyokuni; Izumi Yanatori; Yingyi Kong; Hao Zheng; Yashiro Motooka; Li Jiang

  Cancer science, Aug. 2020, Peer-reviewed

  
• How iron is handled in the course of heme catabolism: Integration of heme oxygenase with intracellular iron transport mechanisms mediated by poly (rC)-binding protein-2.

  Izumi Yanatori; Des R Richardson; Shinya Toyokuni; Fumio Kishi

  Archives of biochemistry and biophysics, 15 Sep. 2019, Peer-reviewed

  
• DMT1 and iron transport.

  Yanatori I; Kishi F

  Free radical biology & medicine, Mar. 2019, Peer-reviewed, Invited

  
• A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.

  Dhekne HS; Yanatori I; Gomez RC; Tonelli F; Diez F; Schüle B; Steger M; Alessi DR; Pfeffer SR; lly contributed

  eLife, Nov. 2018, Peer-reviewed

  
• The iron chaperone poly(rC)-binding protein 2 forms a metabolon with the heme oxygenase 1/cytochrome P450 reductase complex for heme catabolism and iron transfer

  Izumi Yanatori; Des R. Richardson; Shinya Toyokuni; Fumio Kishi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2017, Peer-reviewed

  
• Iron Export through the Transporter Ferroportin 1 Is Modulated by the Iron Chaperone PCBP2

  Izumi Yanatori; Des R. Richardson; Kiyoshi Imada; Fumio Kishi

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2016, Peer-reviewed

  
• Fibroblast activation protein-alpha-expressing fibroblasts promote the progression of pancreatic ductal adenocarcinoma

  Tomoya Kawase; Yumiko Yasui; Sohji Nishina; Yuichi Hara; Izumi Yanatori; Yasuyuki Tomiyama; Yoshihiro Nakashima; Koji Yoshida; Fumio Kishi; Masafumi Nakamura; Keisuke Hino

  BMC GASTROENTEROLOGY, Sep. 2015, Peer-reviewed

  
• Inhibition of iron uptake by ferristatin II is exerted through internalization of DMT1 at the plasma membrane

  Izumi Yanatori; Yumiko Yasui; Yumiko Noguchi; Fumio Kishi

  CELL BIOLOGY INTERNATIONAL, Apr. 2015, Peer-reviewed

  
• Chlamydia pneumoniae CPj0783 interaction with Huntingtin-protein14

  Izumi Yanatori; Yumiko Yasui; Kazunobu Ouchi; Fumio Kishi

  INTERNATIONAL MICROBIOLOGY, 2015, Peer-reviewed

  
• Hepatitis C Virus Core Protein Suppresses Mitophagy by Interacting with Parkin in the Context of Mitochondrial Depolarization

  Yuichi Hara; Izumi Yanatori; Masanori Ikeda; Emi Kiyokage; Sohji Nishina; Yasuyuki Tomiyama; Kazunori Toida; Fumio Kishi; Nobuyuki Kato; Michio Imamura; Kazuaki Chayama; Keisuke Hino

  AMERICAN JOURNAL OF PATHOLOGY, Nov. 2014, Peer-reviewed

  
• Chaperone protein involved in transmembrane transport of iron

  Izumi Yanatori; Yumiko Yasui; Mitsuaki Tabuchi; Fumio Kishi

  BIOCHEMICAL JOURNAL, Aug. 2014, Peer-reviewed

  
• Mutations of FLVCR1 in posterior column ataxia and retinitis pigmentosa result in the loss of heme export activity

  Izumi Yanatori; Yumiko Yasui; Koshiro Miura; Fumio Kishi

  BLOOD CELLS MOLECULES AND DISEASES, Jun. 2012, Peer-reviewed

  
• Genomic screening for Chlamydophila pneumoniae-specific antigens using serum samples from patients with primary infection.

  Yumiko Yasui; Izumi Yanatori; Yasuhiro Kawai; Koshiro Miura; Yoshinori Suminami; Tomomitsu Hirota; Mayumi Tamari; Kazunobu Ouchi; Fumio Kishi

  FEMS microbiology letters, Apr. 2012, Peer-reviewed

  
• Heme and non-heme iron transporters in non-polarized and polarized cells.

  Yanatori I; Tabuchi M; Kawai Y; Yasui Y; Akagi R; Kishi F

  BMC cell biology, Jun. 2010, Peer-reviewed

  
• Retromer-mediated direct sorting is required for proper endosomal recycling of the mammalian iron transporter DMT1.

  Mitsuaki Tabuchi; Izumi Yanatori; Yasuhiro Kawai; Fumio Kishi

  Journal of cell science, Mar. 2010, Peer-reviewed

  
• Development of a Novel Functional High-Throughput Screening System for Pathogen Effectors in the Yeast Saccharomyces cerevisiae

  Mitsuaki Tabuchi; Yasuhiro Kawai; Makiko Nishie-Fujita; Rinji Akada; Terumi Izumi; Izumi Yanatori; Naoyuki Miyashita; Kazunobu Ouchi; Fumio Kishi

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Oct. 2009, Peer-reviewed

  

Misc.

• 細胞内鉄輸送に関わる鉄シャペロンと鉄貯蔵タンパク質の複合体形成の分子機構

  佐藤 渚; 浦 敦人; 簗取 いずみ; 當舎 武彦; 城 宜嗣; 澤井 仁美

  日本生化学会大会プログラム・講演要旨集, Oct. 2023

  
• 鉄応答性に発現制御を受けるCD63陽性小胞によるフェリチン分泌の意義

  簗取いずみ; 豊國伸哉

  月刊血液内科, 2022, Invited, Lead author

  
• 鉄による発現制御を受けるCD63は、細胞外小胞によるフェリチン分泌に重要である

  簗取 いずみ

  生化学, Aug. 2022

  
• Hepatitis C virus core protein suppresses mitophagy by interacting with Parkin

  Yuichi Hara; Sohji Nishina; Izumi Yanatori; Masanori Ikeda; Emi Kiyokage; Yasuyuki Tomiyama; Kazunori Toida; Fumio Kishi; Nobuyuki Kato; Michio Imamura; Kazuaki Chayama; Keisuke Hino

  HEPATOLOGY, Oct. 2013

  
• Iron uptake, delivery, export and storage in hepatocytes

  簗取いずみ

  肝胆膵, 2022

  
• 鉄代謝研究の進歩【極性化細胞での鉄吸収メカニズム】

  簗取いずみ; 岸文雄

  月刊細胞, 2012

  
• 見直されつつある生体鉄 3.腸管における鉄の吸収機構

  岸文雄; 簗取いずみ

  血液フロンティア, 2011

  
• 鉄過剰症-その病態と治療 小腸における鉄吸収メカニズム

  岸文雄; 簗取いずみ

  日本医師会雑誌, 2010

  
• LOSS OF IRON UPREGULATES MITOCHONDRIA FERRITIN AND TRIGGERS MITOPHAGY THROUGH THE BINDING OF MITOCHONDRIA FERRITIN TO NUCLEAR RECEPTOR COACTIVATOR 4

  Yuichi Hara; Izumi Yanatori; Kyo Sasaki; Sohji Nishina; Fumio Kishi; Keisuke Hino

  AMERICAN JOURNAL OF HEMATOLOGY, Aug. 2017

  
• Iron chelator suppresses hepatocarcinogenesis through mitophagy induction in STAM (R) mice

  Yuichi Hara; Izumi Yanatori; Tasuku Hirayama; Hideko Nagasawa; Fumio Kishi; Keisuke Hino

  HEPATOLOGY, Oct. 2016

  
• Hepatitis C virus core protein suppresses mitophagy by interacting with Parkin

  Yuhichi Hara; Izumi Yanatori; Emi Kiyokage; Sohji Nishina; Yasuyuki Tomiyama; Kazunori Toida; Masanori Ikeda; Fumio Kishi; Nobuyuki Kato; Keisuke Hino

  HEPATOLOGY, Oct. 2012

  
• Analysis of the structural requirements for recycling endosome-targeting of DMT1 isoform II

  M. Tabuchi; I. Yanatori; F. Kishi

  AMERICAN JOURNAL OF HEMATOLOGY, Jun. 2007

  

Awards

• 16 Oct. 2014

  第87回日本生化学会大会　若手優秀発表賞
• 07 Sep. 2014

  日本鉄バイオサイエンス学会学術奨励賞

External funds: Kakenhi

• ミトコンドリアフェリチンによるミトコンドリア機能維持と疾患発生の分子機序

  Grant-in-Aid for Scientific Research (C)

  Basic Section 49010:Pathological biochemistry-related

  Yamagata University

  田中 敦

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  ミトコンドリア;ミトコンドリアフェリチン;鉄;オートファジー;マイトファジー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K06851/
• 細胞の恒常性維持における鉄シャペロン分子の機能解析

  Grant-in-Aid for Scientific Research (C)

  Basic Section 48040:Medical biochemistry-related

  Kyoto University;Nagoya University

  簗取 いずみ

  From 01 Apr. 2020, To 31 Mar. 2022, Discontinued

  CD63;鉄応答性制御;フェリチン分泌;鉄シャペロン;鉄代謝;鉄輸送体;鉄

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07309/
• Analysis of the mechanism how iron is transported safely in cytoplasm

  Grant-in-Aid for Research Activity Start-up

  0701:Biology at molecular to cellular levels, and related fields

  Nagoya University

  Izumi Yanatori

  From 30 Aug. 2019, To 31 Mar. 2021, Project Closed

  鉄;鉄代謝;鉄シャペロン;鉄シャペロン分子;フェリチン;シャペロン;細胞内輸送

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K23722/
• 鉄シャペロンによる細胞内鉄分配機構の解明

  Grant-in-Aid for Scientific Research (C)

  Kawasaki Medical School

  簗取 いずみ

  From 01 Apr. 2017, To 31 Mar. 2020, Declined

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K07354/
• Analysis of Chlamydia pneumonia effectors controlling host cell death

  Grant-in-Aid for Young Scientists (B)

  Kawasaki Medical School

  Izumi Yanatori

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  肺炎クラミジア;エフェクター;酵母スクリーニング;細胞内輸送異常;細胞内輸送;アポトーシス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860223/
• Genomic screening for Chlamydophila pneumoniae-specific antigens and development of vaccines

  Grant-in-Aid for Challenging Exploratory Research

  Kawasaki Medical School

  Kazunobu OUCHI

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  肺炎クラミジア;血清学診断法;血清学的診断法;ワクチン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659528/
• Exploring factors of Chlamydia pneumoniae regulating host apoptosis

  Grant-in-Aid for Scientific Research (C)

  Kyushu Women's University;Kawasaki Medical School

  Koshiro MIURA

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  Chlamydia pneumoniae;肺炎クラミジア;アポトーシス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590525/
• Identification and functional analysis of two kinds of novel Chlamydphila pneumoniae effectors

  Grant-in-Aid for Young Scientists (B)

  Kawasaki Medical School

  Izumi YANATORI

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  病原性;肺炎クラミジア;エフェクター;感染制御;III型分泌装置

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790419/
• Analysis of the iron recycling mechanism in the degradation and production process of red blood cell

  Grant-in-Aid for Scientific Research (C)

  Kawasaki Medical School

  Fumio KISHI

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  血液内科学;赤血球;ヘム;鉄;FLVCR1;輸送体;PCARP;二価鉄;DMT1

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591052/
• 細胞内鉄還元メカニズムの解析から鉄取込み機序の全貌解明に挑戦する

  Grant-in-Aid for Scientific Research (C)

  Basic Section 48040:Medical biochemistry-related

  Kyoto University

  簗取 いずみ

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  鉄代謝;還元酵素

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K06377/