Yanatori, Izumi(Graduate School of Medicine, Medicine) | Activity Database on Education and Research, Kyoto University

Yanatori, Izumi

Graduate School of Medicine, Medicine Senior Lecturer/ Junior Associate Professor

Last Updated :2026/11/02

Basic Information

Faculty

Faculty of Medicine

Email Address

Email Address
yanatori.izumi.8nkyoto-u.ac.jp

Academic Degree

14 Mar. 2013
川崎医科大学博士（医学）

Academic Resume (Undergraduate School/Majors)

鹿児島大学, 歯学部歯学科, 卒業

Research History

From Nov. 2026, To Present
University of Tsukuba, Life Science Center for Survival Dynamics Tsukuba Advanced Research Alliance (TARA), Professor

From Jun. 2023, To Oct. 2026
Kyoto University, Department of Molecular and Cellular Physiology Graduate School of Medicine, 講師

ID,URL

J-Global ID
201901012097657339

researchmap URL

https://researchmap.jp/izumiyanatori

Last Updated :2026/11/02

Research

Research Interests

フェロトーシス

老化

鉄シャペロン

エフェクター分子

クラミジア

感染症

酸化ストレス

鉄代謝

Research Areas

Life sciences, Cell biology

Life sciences, Molecular biology

Life sciences, Bacteriology, クラミジア、エフェクター分子

Life sciences, Medical biochemistry

Papers

Safe lysosomal sequestration of ferrous iron is mediated via cholesterol shielding and drives senescence and ferroptosis resistance
Izumi Yanatori; Tasuku Hirayama; Raku Son; Yasuhiro Murakawa; Yuta Matsuoka; Yuki Sugiura; Masato Niwa; Tatsuya Katsuno; Masahiko Tsujimoto; Hiroyuki Yasui; Atsuyasu Sato; Makoto Nakanishi; Kazuhiro Iwai
The EMBO Journal, Oct. 2026, Peer-reviewed, Lead author, Corresponding author

細胞内鉄輸送タンパク質におけるヘムの結合特性ならびに挿入機構
竹下はな; 浦敦人; 簗取いずみ; 杉島正一; 澤井仁美
日本生化学会大会プログラム・講演要旨集, Nov. 2025

細胞内鉄輸送タンパク質の金属結合解析ならびに鉄貯蔵タンパク質Ferritinとの相互作用解析
佐藤渚; 浦敦人; 長尾春代; 簗取いずみ; 當舎武彦; 城宜嗣; 澤井仁美
日本生化学会大会プログラム・講演要旨集, Nov. 2025

細胞内鉄輸送タンパク質におけるヘムの結合特性ならびに挿入機構
竹下はな; 浦敦人; 簗取いずみ; 杉島正一; 澤井仁美
日本生化学会大会プログラム・講演要旨集, Nov. 2025

Ferroptosis: biology and role in liver disease
Keisuke Hino·; Sohji Nishina; Izumi Yanatori
Journal of Gastroenterology, Sep. 2025, Peer-reviewed, Last author, Corresponding author
Access this paper :

細胞内鉄動態とフェリチン分泌の分子メカニズム
𥱋取いずみ
臨床血液, 2023, Peer-reviewed, Invited, Lead author, Last author, Corresponding author

Iron metabolism and ferroptosis
Shinya Toyokuni; Izumi Yanatori
Ferroptosis in Health and Disease, 10 Oct. 2019

細胞内鉄輸送タンパク質PCBP1における鉄イオンの結合と輸送の分子メカニズム
浦敦人; 簗取いずみ; 城宜嗣; 澤井仁美
日本生化学会大会プログラム・講演要旨集, Nov. 2022

Association of poly(rC)-binding protein-2 with sideroflexin-3 through TOM20 as an iron entry pathway to mitochondria.
Danyang Mi; Izumi Yanatori; Hao Zheng; Yingyi Kong; Tasuku Hirayama; Shinya Toyokuni
Free radical research, 10 Apr. 2024, Peer-reviewed

Protocol for the isolation of GFP-expressing ferroptosis-dependent extracellular vesicles in in vitro cell culture models.
Fumiya Ito; Izumi Yanatori; Katsuhiro Kato; Shinya Toyokuni
STAR protocols, 15 Mar. 2024, Peer-reviewed, Invited

New iron export pathways acting via holo-ferritin secretion.
Izumi Yanatori; Fumio Kishi; Shinya Toyokuni
Archives of biochemistry and biophysics, 06 Sep. 2023, Peer-reviewed, Invited, Lead author, Corresponding author

Iron links endogenous and exogenous nanoparticles.
Shinya Toyokuni; Yingyi Kong; Misako Katabuchi; Yuki Maeda; Yashiro Motooka; Fumiya Ito; Izumi Yanatori
Archives of biochemistry and biophysics, 01 Sep. 2023, Peer-reviewed, Invited

Newly uncovered biochemical and functional aspects of ferritin.
Izumi Yanatori; Sohji Nishina; Fumio Kishi; Keisuke Hino
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Aug. 2023, Peer-reviewed, Lead author

Matrigel-based organoid culture of malignant mesothelioma reproduces cisplatin sensitivity through CTR1.
Fumiya Ito; Katsuhiro Kato; Izumi Yanatori; Yuki Maeda; Toyoaki Murohara; Shinya Toyokuni
BMC cancer, 31 May 2023, Peer-reviewed

Ferroptosis-dependent extracellular vesicles from macrophage contribute to asbestos-induced mesothelial carcinogenesis through loading ferritin.
Fumiya Ito; Katsuhiro Kato; Izumi Yanatori; Toyoaki Murohara; Shinya Toyokuni
Redox biology, Nov. 2021, Peer-reviewed

Iron and liver cancer: an inseparable connection.
Keisuke Hino; Izumi Yanatori; Yuichi Hara; Sohji Nishina
The FEBS journal, 20 Sep. 2021, Peer-reviewed, Invited

CD63 is regulated by iron via the IRE-IRP system and is important for ferritin secretion by extracellular vesicles.
Izumi Yanatori; Des R Richardson; Herschel S Dhekne; Shinya Toyokuni; Fumio Kishi
Blood, 21 Oct. 2021, Peer-reviewed, Lead author

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade.
Herschel S Dhekne*; Izumi Yanatori*(*equally contributed); Edmundo G Vides; Yuriko Sobu; Federico Diez; Francesca Tonelli; Suzanne R Pfeffer
Life science alliance, May 2021, Peer-reviewed, Lead author

Application of a C. trachomatis expression system to identify C. pneumoniae proteins translocated into host cells.
Izumi Yanatori; Koshiro Miura; Yi-Shan Chen; Raphael H Valdivia; Fumio Kishi
Journal of bacteriology, 08 Mar. 2021, Peer-reviewed, Lead author

Carcinogenesis as Side Effects of Iron and Oxygen Utilization: From the Unveiled Truth toward Ultimate Bioengineering.
Shinya Toyokuni; Yingyi Kong; Zhen Cheng; Kotaro Sato; Shotaro Hayashi; Fumiya Ito; Li Jiang; Izumi Yanatori; Yasumasa Okazaki; Shinya Akatsuka
Cancers, 10 Nov. 2020, Peer-reviewed

Iron loss triggers mitophagy through induction of mitochondrial ferritin.
Yuichi Hara; Izumi Yanatori; Atsushi Tanaka; Fumio Kishi; John J Lemasters; Sohji Nishina; Kyo Sasaki; Keisuke Hino
EMBO reports, 05 Nov. 2020, Peer-reviewed

The new role of poly (rC)-binding proteins as iron transport chaperones: Proteins that could couple with inter-organelle interactions to safely traffic iron.
Izumi Yanatori; Des R Richardson; Shinya Toyokuni; Fumio Kishi
Biochimica et biophysica acta. General subjects, Nov. 2020, Peer-reviewed, Lead author

Asbestos conceives Fe(II)-dependent mutagenic stromal milieu through ceaseless macrophage ferroptosis and β-catenin induction in mesothelium.
Fumiya Ito; Izumi Yanatori; Yuki Maeda; Kenta Nimura; Satoki Ito; Tasuku Hirayama; Hideko Nagasawa; Norihiko Kohyama; Yasumasa Okazaki; Shinya Akatsuka; Shinya Toyokuni
Redox biology, Sep. 2020, Peer-reviewed

Ferroptosis at the crossroads of infection, aging and cancer.
Shinya Toyokuni; Izumi Yanatori; Yingyi Kong; Hao Zheng; Yashiro Motooka; Li Jiang
Cancer science, Aug. 2020, Peer-reviewed

How iron is handled in the course of heme catabolism: Integration of heme oxygenase with intracellular iron transport mechanisms mediated by poly (rC)-binding protein-2.
Izumi Yanatori; Des R Richardson; Shinya Toyokuni; Fumio Kishi
Archives of biochemistry and biophysics, 15 Sep. 2019, Peer-reviewed

DMT1 and iron transport.
Yanatori I; Kishi F
Free radical biology & medicine, Mar. 2019, Peer-reviewed, Invited

A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain.
Dhekne HS; Yanatori I; Gomez RC; Tonelli F; Diez F; Schüle B; Steger M; Alessi DR; Pfeffer SR; lly contributed
eLife, Nov. 2018, Peer-reviewed

The iron chaperone poly(rC)-binding protein 2 forms a metabolon with the heme oxygenase 1/cytochrome P450 reductase complex for heme catabolism and iron transfer
Izumi Yanatori; Des R. Richardson; Shinya Toyokuni; Fumio Kishi
JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2017, Peer-reviewed

Iron Export through the Transporter Ferroportin 1 Is Modulated by the Iron Chaperone PCBP2
Izumi Yanatori; Des R. Richardson; Kiyoshi Imada; Fumio Kishi
JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2016, Peer-reviewed

Fibroblast activation protein-alpha-expressing fibroblasts promote the progression of pancreatic ductal adenocarcinoma
Tomoya Kawase; Yumiko Yasui; Sohji Nishina; Yuichi Hara; Izumi Yanatori; Yasuyuki Tomiyama; Yoshihiro Nakashima; Koji Yoshida; Fumio Kishi; Masafumi Nakamura; Keisuke Hino
BMC GASTROENTEROLOGY, Sep. 2015, Peer-reviewed

Inhibition of iron uptake by ferristatin II is exerted through internalization of DMT1 at the plasma membrane
Izumi Yanatori; Yumiko Yasui; Yumiko Noguchi; Fumio Kishi
CELL BIOLOGY INTERNATIONAL, Apr. 2015, Peer-reviewed

Chlamydia pneumoniae CPj0783 interaction with Huntingtin-protein14
Izumi Yanatori; Yumiko Yasui; Kazunobu Ouchi; Fumio Kishi
INTERNATIONAL MICROBIOLOGY, 2015, Peer-reviewed

Hepatitis C Virus Core Protein Suppresses Mitophagy by Interacting with Parkin in the Context of Mitochondrial Depolarization
Yuichi Hara; Izumi Yanatori; Masanori Ikeda; Emi Kiyokage; Sohji Nishina; Yasuyuki Tomiyama; Kazunori Toida; Fumio Kishi; Nobuyuki Kato; Michio Imamura; Kazuaki Chayama; Keisuke Hino
AMERICAN JOURNAL OF PATHOLOGY, Nov. 2014, Peer-reviewed

Chaperone protein involved in transmembrane transport of iron
Izumi Yanatori; Yumiko Yasui; Mitsuaki Tabuchi; Fumio Kishi
BIOCHEMICAL JOURNAL, Aug. 2014, Peer-reviewed

Mutations of FLVCR1 in posterior column ataxia and retinitis pigmentosa result in the loss of heme export activity
Izumi Yanatori; Yumiko Yasui; Koshiro Miura; Fumio Kishi
BLOOD CELLS MOLECULES AND DISEASES, Jun. 2012, Peer-reviewed

Genomic screening for Chlamydophila pneumoniae-specific antigens using serum samples from patients with primary infection.
Yumiko Yasui; Izumi Yanatori; Yasuhiro Kawai; Koshiro Miura; Yoshinori Suminami; Tomomitsu Hirota; Mayumi Tamari; Kazunobu Ouchi; Fumio Kishi
FEMS microbiology letters, Apr. 2012, Peer-reviewed

Heme and non-heme iron transporters in non-polarized and polarized cells.
Yanatori I; Tabuchi M; Kawai Y; Yasui Y; Akagi R; Kishi F
BMC cell biology, Jun. 2010, Peer-reviewed

Retromer-mediated direct sorting is required for proper endosomal recycling of the mammalian iron transporter DMT1.
Mitsuaki Tabuchi; Izumi Yanatori; Yasuhiro Kawai; Fumio Kishi
Journal of cell science, Mar. 2010, Peer-reviewed

Development of a Novel Functional High-Throughput Screening System for Pathogen Effectors in the Yeast Saccharomyces cerevisiae
Mitsuaki Tabuchi; Yasuhiro Kawai; Makiko Nishie-Fujita; Rinji Akada; Terumi Izumi; Izumi Yanatori; Naoyuki Miyashita; Kazunobu Ouchi; Fumio Kishi
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Oct. 2009, Peer-reviewed

Misc.

鉄シャペロンタンパク質PCBPによる鉄イオン輸送機構の解明
浦敦人; 簗取いずみ; 城宜嗣; 澤井仁美
日本蛋白質科学会年会(Web), 2023

鉄シャペロンPCBPは鉄イオンをフェリチンのH鎖に輸送する
浦敦人; 浦敦人; 佐藤渚; 簗取いずみ; 城宜嗣; 當舎武彦; 澤井仁美; 澤井仁美
日本鉄バイオサイエンス学会学術集会プログラム・抄録集, 2024

膜貫通型鉄還元酵素Dcytbから二価金属輸送体DMT1へのFe²⁺授受機構の解析
坂上正虎; 柴田晃利; 藤宇将吾; 高原教代; 簗取いずみ; 城宜嗣; 當舎武彦; 澤井仁美; 澤井仁美
日本生化学会大会(Web), 2024

鉄イオンの吸収に関与する二価金属輸送体DMT1の構造解析に向けた精製法の検討
大谷豪; 柴田晃利; 藤宇将吾; 高原教代; 簗取いずみ; 當舎武彦; 城宜嗣; 澤井仁美; 澤井仁美
日本生化学会大会(Web), 2024

IRON LOSS-INDUCED MITOPHAGY VIA MITOCHONDRIA FERRITIN SUPPRESSES NASH-RELATED HEPATOCELLULAR CARCINOMA
Yuichi Hara; Atsushi Tanaka; Izumi Yanatori; Kyo Sasaki; Sohji Nishina; Keisuke Hino
HEPATOLOGY, Oct. 2019

Mitochondria Ferritin Induces Mitophagy Under Iron Deficient Condition
Koji Nara; Atsushi Tanaka; Izumi Yanatori; Kyo Sasaki; Sohji Nishina; Keisuke Hino
HEPATOLOGY, Oct. 2018

Books and Other Publications

Iron in Biology: Molecular Structures, Cellular Processes and Living Systems
Yanatori I.; Sawai H., Contributor, Chapter 1: Introduction to Iron Dynamics in Human Cells: Fundamental Mechanisms and Updates
Royal Society of Chemistry, Jun. 2025
Find Kyoto University's collection of books :

生命金属ダイナミクス : 生体内における金属の挙動と制御
𥱋取いずみ; 岸文雄, Contributor, 第1章維持─生命と金属─ 第1節二価鉄輸送体DMT1 研究から鉄シャペロンの発見に至る細胞内鉄輸送機構の解析
エヌ・ティー・エス, Jan. 2021
Find Kyoto University's collection of books :

Awards

16 Oct. 2014
第87回日本生化学会大会　若手優秀発表賞

07 Sep. 2014
日本鉄バイオサイエンス学会学術奨励賞

External funds: Kakenhi

Molecular mechanisms of mitochondrial maintenance and disease development by mitochondrial ferritin.
Grant-in-Aid for Scientific Research (C)
Basic Section 49010:Pathological biochemistry-related
Yamagata University
Atsushi TANAKA
From 01 Apr. 2021, To 31 Mar. 2024, Project Closed
ミトコンドリア;マイトファジー;鉄;ミトコンドリアフェリチン（FTMT);オートファジー;ミトコンドリアフェリチン
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21K06851/

細胞の恒常性維持における鉄シャペロン分子の機能解析
Grant-in-Aid for Scientific Research (C)
Basic Section 48040:Medical biochemistry-related
Kyoto University;Nagoya University
簗取いずみ
From 01 Apr. 2020, To 31 Mar. 2022, Discontinued
CD63;鉄応答性制御;フェリチン分泌;鉄シャペロン;鉄代謝;鉄輸送体;鉄
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K07309/

Analysis of the mechanism how iron is transported safely in cytoplasm
Grant-in-Aid for Research Activity Start-up
0701:Biology at molecular to cellular levels, and related fields
Nagoya University
Izumi Yanatori
From 30 Aug. 2019, To 31 Mar. 2021, Project Closed
鉄;鉄代謝;鉄シャペロン;鉄シャペロン分子;フェリチン;シャペロン;細胞内輸送
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K23722/

鉄シャペロンによる細胞内鉄分配機構の解明
Grant-in-Aid for Scientific Research (C)
Kawasaki Medical School
簗取いずみ
From 01 Apr. 2017, To 31 Mar. 2020, Declined
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K07354/

Analysis of Chlamydia pneumonia effectors controlling host cell death
Grant-in-Aid for Young Scientists (B)
Kawasaki Medical School
Izumi Yanatori
From 01 Apr. 2014, To 31 Mar. 2016, Project Closed
肺炎クラミジア;エフェクター;酵母スクリーニング;細胞内輸送異常;細胞内輸送;アポトーシス
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860223/

Genomic screening for Chlamydophila pneumoniae-specific antigens and development of vaccines
Grant-in-Aid for Challenging Exploratory Research
Kawasaki Medical School
Kazunobu OUCHI
From 01 Apr. 2011, To 31 Mar. 2014, Project Closed
肺炎クラミジア;血清学診断法;血清学的診断法;ワクチン
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659528/

Exploring factors of Chlamydia pneumoniae regulating host apoptosis
Grant-in-Aid for Scientific Research (C)
Kyushu Women's University;Kawasaki Medical School
Koshiro MIURA
From 01 Apr. 2011, To 31 Mar. 2014, Project Closed
Chlamydia pneumoniae;肺炎クラミジア;アポトーシス
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23590525/

Identification and functional analysis of two kinds of novel Chlamydphila pneumoniae effectors
Grant-in-Aid for Young Scientists (B)
Kawasaki Medical School
Izumi YANATORI
From 01 Apr. 2010, To 31 Mar. 2013, Project Closed
病原性;肺炎クラミジア;エフェクター;感染制御;III型分泌装置
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790419/

Analysis of the iron recycling mechanism in the degradation and production process of red blood cell
Grant-in-Aid for Scientific Research (C)
Kawasaki Medical School
Fumio KISHI
From 01 Apr. 2010, To 31 Mar. 2013, Project Closed
血液内科学;赤血球;ヘム;鉄;FLVCR1;輸送体;PCARP;二価鉄;DMT1
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591052/

細胞内鉄還元メカニズムの解析から鉄取込み機序の全貌解明に挑戦する
Grant-in-Aid for Scientific Research (C)
Basic Section 48040:Medical biochemistry-related
Kyoto University
簗取いずみ
From 01 Apr. 2023, To 31 Mar. 2026, Granted
鉄代謝;フェロトーシス;還元酵素
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K06377/

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