Basic Information

Faculty

• 医学部

Professional Memberships

• From 2024, To Present

  The physiological Society Japan
• From 2008, To Present

  Japan Neuroscience Society
• From 2006, To Present

  Society for Neuroscience

Academic Degree

• 修士（工学）(東京大学)
• 博士（科学）(東京大学)

Research History

• From Mar. 2025, To Present

  Kagoshima University, Graduate School of Medical and Dental Sciences, Professor
• From Feb. 2023, To Feb. 2025

  Kyoto University, Graduate School of Medicine, Associate Professor
• From Sep. 2014, To Jan. 2023

  Kyoto University, Graduate School of Medicine, Senior Lecturer
• From Apr. 2014, To Aug. 2014

  Kyoto University, Department of Biostudies, Lecturer
• From Apr. 2010, To Mar. 2014

  Duke University Mooney Lab, Postdoctral Fellow
• From Apr. 2008, To Mar. 2010

  Duke University Mooney Lab, 日本学術振興会 海外特別研究員
• From Apr. 2006, To Mar. 2008

  RIKEN, 日本学術振興会 特別研究員
• From Jun. 2006, To Jan. 2008

  Centre National de la Recherche Scientifique, 訪問研究員
• From Apr. 2004, To Mar. 2006

  RIKEN, 研究員
• To Mar. 2004

  東京大学 複雑理工学 博士課程終了

Profile

• Profile

  Currently, I'm working on neural circuits of songbirds to understand the neural basis of the complex motor learning (song learning) by using in-vivo electrophysiology and computational neuroscience.

ID,URL

• ORCID ID

  0000-0002-0540-320X

• J-Global ID

  201101036869974480

• External link

  https://www3.kufm.kagoshima-u.ac.jp/physiol1/en/

researchmap URL

• https://researchmap.jp/hamaguchikosuke

Research

Research Topics, Overview of the research

• Research Topics

  system neuroscience, imaging, electrophysiology, reinforcement learning, spiking neuron models, neural network
  

Research Interests

• Decision Making
• 強化学習
• 運動野
• 神経生理
• 大脳基底核

Research Areas

• Life sciences, Clinical pharmacy, motor learning, computational neuroscience
• Life sciences, Physiology, motor learning, computational neuroscience
• Life sciences, Neuroscience - general, motor learning, computational neuroscience
• Informatics, Sensitivity (kansei) informatics
• Informatics, Soft computing

Papers

• Distinct Roles of Dopamine D1 and D2 Receptor-expressing Neurons in the Nucleus Accumbens for a Strategy Dependent Decision Making

  Tadaaki Nishioka; Tom Macpherson; Kosuke Hamaguchi; Takatoshi Hikida

  bioRxiv, 05 Aug. 2021

  
• Error-related signaling in nucleus accumbens D2 receptor-expressing neurons guides inhibition-based choice behavior in mice

  Tadaaki Nishioka; Suthinee Attachaipanich; Kosuke Hamaguchi; Michael Lazarus; Alban de Kerchove d’Exaerde; Tom Macpherson; Takatoshi Hikida

  Nature Communications, 21 Apr. 2023

  
• Prospective and retrospective values integrated in frontal cortex drive predictive choice.

  Kosuke Hamaguchi; Hiromi Takahashi-Aoki; Dai Watanabe

  Proceedings of the National Academy of Sciences of the United States of America, 29 Nov. 2022

  Access this paper :

  
• Error-related Signaling in Nucleus Accumbens D2 Receptor-expressing Neurons Guides Avoidance-based Goal-directed Behavior

  Tadaaki Nishioka; Tom Macpherson; Kosuke Hamaguchi; Takatoshi Hikida

  05 Jan. 2022

  
• Chemogenetic Suppression of the Subthalamic Nucleus Induces Attentional Deficits and Impulsive Action in a Five-Choice Serial Reaction Time Task in Mice.

  Tadaaki Nishioka; Kosuke Hamaguchi; Satoshi Yawata; Takatoshi Hikida; Dai Watanabe

  Frontiers in systems neuroscience, Jun. 2020, Peer-reviewed

  
• Neural circuits mediating neural and behavior sequencing

  Hamaguchi Kosuke

  Transactions of Japanese Society for Medical and Biological Engineering, 2015

  
• A Distributed Recurrent Network Contributes to Temporally Precise Vocalizations

  Kosuke Hamaguchi; Masashi Tanaka; Richard Mooney

  NEURON, Aug. 2016, Peer-reviewed

  
• Auditory synapses to song premotor neurons are gated off during vocalization in zebra finches

  Kosuke Hamaguchi; Katherine A. Tschida; Inho Yoon; Bruce R. Donald; Richard Mooney

  ELIFE, Feb. 2014, Peer-reviewed

  
• Intracellular Neural Recording with Pure Carbon Nanotube Probes

  Inho Yoon; Kosuke Hamaguchi; Ivan V. Borzenets; Gleb Finkelstein; Richard Mooney; Bruce R. Donald

  PLOS ONE, Jun. 2013, Peer-reviewed

  
• Recurrent Interactions between the Input and Output of a Songbird Cortico-Basal Ganglia Pathway Are Implicated in Vocal Sequence Variability

  Kosuke Hamaguchi; Richard Mooney

  JOURNAL OF NEUROSCIENCE, Aug. 2012, Peer-reviewed

  
• Estimating Network Parameters From Combined Dynamics of Firing Rate and Irregularity of Single Neurons

  Kosuke Hamaguchi; Alexa Riehle; Nicolas Brunel

  JOURNAL OF NEUROPHYSIOLOGY, Jan. 2011, Peer-reviewed

  
• Local excitation solutions in one-dimensional neural fields by external input stimuli

  Shigeru Kubota; Kosuke Hamaguchi; Kazuyuki Aihara

  NEURAL COMPUTING & APPLICATIONS, Sep. 2009, Peer-reviewed

  
• Effect of asymmetry in a binary state on the collective behavior of a system with spatially modulated interaction and quenched randomness

  Kosuke Hamaguchi; Hiromitsu Urano; Masato Okada

  PHYSICAL REVIEW E, Nov. 2008, Peer-reviewed

  
• Dynamics and computation of continuous attractors

  Si Wu; Kosuke Hamaguchi; Shun-ichi Amari

  NEURAL COMPUTATION, Apr. 2008, Peer-reviewed

  
• Sparse and dense encoding in layered associative network of spiking neurons

  Kazuya Ishibashi; Kosuke Hamaguchi; Masato Okada

  JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN, Dec. 2007, Peer-reviewed

  
• Variable timescales of repeated spike patterns in synfire chain with Mexican-hat connectivity

  Kosuke Hamaguchi; Masato Okada; Kazuyuki Aihara

  NEURAL COMPUTATION, Sep. 2007, Peer-reviewed

  
• The tracking speed of continuous attractors

  Si Wu; Kosuke Hamaguchi; Shun-ichi Amari

  ADVANCES IN NEURAL NETWORKS - ISNN 2007, PT 1, PROCEEDINGS, 2007, Peer-reviewed

  
• Theory of interaction of memory patterns in layered associative networks

  Kazuya Ishibashi; Kosuke Hamaguchi; Masato Okada

  JOURNAL OF THE PHYSICAL SOCIETY OF JAPAN, Nov. 2006, Peer-reviewed

  
• Analytic solution of neural network with disordered lateral inhibition

  K Hamaguchi; JPL Hatchett; M Okada

  PHYSICAL REVIEW E, May 2006, Peer-reviewed

  
• Correlated firing in a feedforward network with Mexican-hat-type connectivity

  K Hamaguchi; M Okada; M Yamana; K Aihara

  NEURAL COMPUTATION, Sep. 2005, Peer-reviewed

  
• Stochastic resonance of localized activity driven by common noise

  Kosuke Hamaguchi; Masato Okada; Shigeru Kubota; Kazuyuki Aihara

  Biological Cybernetics, Jun. 2005, Peer-reviewed

  
• Stochasticity in localized synfire chain

  K Hamaguchi; M Okada; M Yamana; K Aihara

  NEUROCOMPUTING, Jun. 2005, Peer-reviewed

  
• Theory of Synfire Chain with Mexican-Hat Connectivity

  HAMAGUCHI Kosuke; OKADA Masato; YAMANA Michiko; AIHARA Kazuyuki

  The transactions of the Institute of Electronics, Information and Communication Engineers. D-II, 01 Aug. 2004

  
• Quantitative information transfer through layers of spiking neurons connected by Mexican-Hat-type connectivity

  K Hamaguchi; K Aihara

  NEUROCOMPUTING, Jun. 2004, Peer-reviewed

  
• Theory of localized synfire chain: characteristic propagation speed of stable spike pattern.

  Kosuke Hamaguchi; Masato Okada; Kazuyuki Aihara

  Advances in Neural Information Processing Systems 17 [Neural Information Processing Systems, NIPS 2004, December 13-18, 2004, Vancouver, British Columbia, Canada], 2004, Peer-reviewed

  

Misc.

• Colored Noise Stabilizes Asynchronous Persistent Activity

  HAMAGUCHI Kosuke; BRUNEL Nicolas

  IEICE technical report, 11 Nov. 2007

  
• Inhibition-dominated network can explain multistability and highly irregular states in prefrontal cortex activity

  HAMAGUCHI Kosuke; BRUNEL Nicolas

  IEICE technical report, 07 Mar. 2007

  
• Two-layer neural field model for working memory task with intervening stimulus

  Kubota Shigeru; Okamoto Tsuyoshi; Hamaguchi Kosuke; Aihara Kazuyuki; Kitajima Tatsuo

  IEICE technical report. Nonlinear problems, 10 May 2005

  
• 25aYF-7 Statistical Mechanics of Spinglass with Local Structure

  Hamaguchi K.; Okada M.

  Meeting abstracts of the Physical Society of Japan, 04 Mar. 2005

  
• 13aTC-6 Analysis of Localized Synfire Chain with Fokker-Planck Equaions

  HAMAGUCHI K; OKADA M; AIHARA K

  Meeting abstracts of the Physical Society of Japan, 25 Aug. 2004

  
• Analysis of Synfire Chain with Mexican-Hat type Connectivity

  Hamaguchi Kosuke; Okada Masato; Yamana Michiko; Aihara Kazuyuki

  Meeting abstracts of the Physical Society of Japan, 15 Aug. 2003

  
• 13aTC-5 Statistical Mechanics of Spin System with Mexican-Hat type Interaction

  HAMAGUCHI K; OKADA M; AIHARA K

  Meeting abstracts of the Physical Society of Japan, 25 Aug. 2004

  
• Analyzing local excitation in a neural field model

  KUBOTA Shigeru; HAMAGUCHI Kosuke; AIHARA Kazuyuki

  IEICE technical report. Neurocomputing, 22 Mar. 2005

  
• 29pXH-11 Statistical Mechanics of McCulloch-Pitts Networks with Mexican-Hat Interaction

  Urano Hiromitsu; Hamaguchi Kosuke; Okada Masato

  Meeting abstracts of the Physical Society of Japan, 04 Mar. 2006

  
• 29pXH-4 Analysis of Associative Synfire Chain with Fokker-Planck Equations

  Ishibashi Kazuya; Hamaguchi Kosuke; Okada Masato

  Meeting abstracts of the Physical Society of Japan, 04 Mar. 2006

  
• 21aWB-1 Oscillatory States in a Model of Visual Cortex with Synaptic Delay

  Hamaguchi Kosuke; Nicolas Brunel

  Meeting abstracts of the Physical Society of Japan, 28 Feb. 2007

  
• 21pWB-2 Comparative Study on Ising and McCulloch-Pitts Neural Networks with Random Interaction

  Urano Hiromitsu; Hamaguchi Kosuke; Okada Masato

  Meeting abstracts of the Physical Society of Japan, 28 Feb. 2007

  
• 21aWB-6 Sparsely Encoded Associative Synfire Chain

  Ishibashi Kazuya; Hamaguchi Kosuke; Okada Masato

  Meeting abstracts of the Physical Society of Japan, 28 Feb. 2007

  
• sparse coding promote the stability of synchronous memory pattern propagation

  ISHIBASHI Kazuya; HAMAGUCHI Kosuke; OKADA Masato

  IEICE technical report, 07 Mar. 2007

  
• Comparative Study on Ising and McCulloch-Pitts Neural Networks with Random Interacrion

  URANO Hiromitsu; HAMAGUCHI Kosuke; OKADA Masato

  IEICE technical report, 19 Jan. 2007

  
• Fokker-Planck Analysis of Associative Synfire Chain

  ISHIBASHI Kazuya; HAMAGUCHI Kosuke; OKADA Masato

  IEICE technical report, 10 Mar. 2006

  
• Memory patterns interaction in layered associative network

  Kazuya Ishibashi; Kosuke Hamaguchi; Masato Okada

  NEUROSCIENCE RESEARCH, 2006

  
• Stochastic Resonance of Localized Bump Driven by Common Noise

  HAMAGUCHI Kosuke; OKADA Masato; KUBOTA Sigeru; AIHARA Kazuyuki

  IEICE technical report. Neurocomputing, 17 Jun. 2004

  
• Quantitative infonnation transfer through layers of spiking neurons connected by Mexican-Hat-type connectivity

  K Hamaguchi; K Aihara

  COMPUTATIONAL NEUROSCIENCE: TRENDS IN RESEARCH 2004, 2004

  
• Analysis of Synfire Chain with Mexican-Hat Connectivity

  HAMAGUCHI Kosuke; OKADA Masato; YAMANA Michiko; AIHARA Kazuyuki

  IEICE technical report. Neurocomputing, 20 Jun. 2003

  

External funds: Kakenhi

• 予測的価値を行動に変換する神経機構

  Grant-in-Aid for Scientific Research (B)

  Basic Section 51020:Cognitive and brain science-related

  Kyoto University

  濱口 航介

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  意思決定;予測;２光子カルシウムイメージング;光遺伝学;強化学習;高次運動野;予測的行動;カルシウムイメージング;システム神経科学;２光子顕微鏡

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02804/
• 意思決定過程と内部モデルの相互作用

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  濱口 航介

  From 01 Apr. 2019, To 31 Mar. 2021, Project Closed

  システム神経科学;予測的行動;強化学習;光遺伝学;内部モデル;カルシウムイメージング;二光子カルシウムイメージング;機能マッピング

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-19H04983/
• 神経活動と分子活性が織り成す学習規則の可視化

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  濱口 航介

  From 01 Apr. 2017, To 31 Mar. 2019, Project Closed

  カルシウムイメージング;関心領域;内部モデル;強化学習;システム神経科学;分子活性;神経科学;神経可塑性;イメージング

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-17H06029/
• Neural basis of imitative learning

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Kosuke Hamaguchi

  From 01 Apr. 2017, To 31 Mar. 2020, Project Closed

  外界のモデル化;行動選択;報酬学習;カルシウムイメージング;システム神経科学;強化学習;神経科学;模倣学習;細胞内膜電位記録

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17H03545/
• Neural basis of timing control in motor sequence

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Kosuke Hamaguchi

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  時間制御;synfire chain;小鳥;温度操作;細胞内膜電位記録;システム神経科学;細胞内記録;songbird;temperature manipulation;brainstem feedback;sequential activity;intracellular recording

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K18340/
• Development of measuring neural activity in a freely behaving animal

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Dai Watanabe

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  電気生理学;細胞内記録;光学的計測;光遺伝学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K14315/
• Neural basis of syntactic information processing

  Grant-in-Aid for Scientific Research (S)

  Kyoto University

  Dai Watanabe

  From 31 May 2012, To 31 Mar. 2017, Project Closed

  ソングバード;音声学習;基底核;文法情報;文法;音声制御;神経回路;文法規則;模倣学習;社会学習;ウイルスベクター

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24220009/
• 相関を無視した神経情報デコーディングに関する研究

  Grant-in-Aid for Young Scientists (B)

  The Institute of Physical and Chemical Research

  濱口 航介

  From 01 Apr. 2006, To 31 Mar. 2007, Project Closed

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18700238/
• 逆行性バーコーディングによる局所神経回路構造の解明

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  濱口 航介

  From 16 Jun. 2022, To 31 Mar. 2024, Granted

  バーコード;逆行性ウィルス;２光子カルシウムイメージング;透明化;局所回路;FISH;拡大透明化;空間トランスクリプトミクス;バーコード化;狂犬病ウィルス;カルシウムイメージング;短期記憶

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22H05495/
• Neural mechanism of action selection guided by interoception

  Grant-in-Aid for Scientific Research (B)

  Basic Section 51020:Cognitive and brain science-related

  Kyoto University

  濱口 航介

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  カルシウムイメージング;行動選択;口渇;塩欲求

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02343/
• Local circuit census with retro-barcoding

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  濱口 航介

  From 01 Apr. 2024, To 31 Mar. 2026, Granted

  バーコード;空間トランスクリプトーム;カルシウムイメージング;狂犬病ウィルス

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-24H01235/