Researchers Information System

日本語に切り替えるswitch to english

Search for faculty members

Advanced SearchSearch by organization

Murakami, Kazuma

Graduate School of Agriculture, Division of Food Science and Biotechnology Associate Professor

Murakami, Kazuma
list
    Last Updated :2025/04/29

    Basic Information

    Faculty

    • 農学部

    Email Address

    • Email Address

      murakami.kazuma.4vkyoto-u.ac.jp

    Professional Memberships

    • 日本ケミカルバイオロジー学会
    • 日本基礎老化学会
    • アメリカ神経科学会
    • アメリカ化学会
    • 日本認知症学会
    • 日本ペプチド学会
    • 日本農芸化学会
    • 日本核酸医薬学会
    • The Japan Society of Nucleic Acids Chemistry

    Academic Degree

    • 修士（農学）(京都大学)
    • 博士（農学）(京都大学)

    Academic Resume (Graduate Schools)

    • 京都大学, 大学院農学研究科博士後期課程食品生物科学専攻, 修了
    • 京都大学, 大学院農学研究科修士課程食品生物科学専攻, 修了

    Academic Resume (Undergraduate School/Majors)

    • 京都大学, 農学部生物機能科学科, 卒業

    High School

    • High School

      清風高等学校

    Research History

    • From 2013, To Present
      京都大学大学農学研究科准教授
    • From 2009, To 2013
      京都大学農学研究科助教
    • From 2007, To 2009
      日本学術振興会特別研究員SPD
    • From 2004, To 2007
      日本学術振興会特別研究員DC1

    ID,URL

    Website(s) (URL(s))

    researchmap URL

    list
      Last Updated :2025/04/29

      Research

      Research Topics, Overview of the research

      • Research Topics

        1. Molecular basis of functional food components and herbal medicine and organic synthesis of active compounds, 2. Searching of target proteins with biomolecules, 3. Development of DNA/RNA aptamer targeting biomolecules, 4. Synthesis of active analogues of antisense nucleic acid

      • Overview of the research

        生体関連物質に関する作用機構の解明のため、高磁場NMRおよび高感度MSなどの機器分析、フラボノイド合成、分子生物学的手法を用いた細胞実験を行っている。生体分子の一例として、アルツハイマー病因物質であるアミロイドβオリゴマーに着目し、細胞内標的タンパク質や内因性DNA/RNAアプタマーを探索している。また、得られたアプタマーの配列に基づいて、低分解性アナログやペプチド核酸アナログを化学合成する。さらに、食品・漢方薬に含まれる天然物に着目し、動物実験でアルツハイマー病の予防効果を明らかにした化合物について脳内における代謝機構（活性本体の同定）を調べている。以上の研究テーマを推進することで、有機化学を通じて食品生物科学における未解決課題に挑む。

      Research Interests

      • Biochemistry
      • Chemical Biology
      • Nucleic Biological Chemistry
      • Peptide Chemistry
      • Bioorganic Chemistry

      Research Areas

      • Life sciences, Bioorganic chemistry
      • Nanotechnology/Materials, Molecular biochemistry

      Papers

      • Neurotoxic Implications of Human Coronaviruses in Neurodegenerative Diseases: A Perspective from Amyloid Aggregation
        Thi Hong Van Nguyen; Francois Ferron; Kazuma Murakami
        ACS Chemical Biology, 24 Apr. 2025
      • Detection of Dietary Chalcone and Flavonoid Metabolites in Mice Using UPLC–MS/MS and Their Modulatory Effects on Amyloid β Aggregation
        Kota Taniwa; Kazuma Murakami; Yoshiki Sakaguchi; Naotaka Izuo; Mizuho Hanaki; Nobuaki Sampa; Toshiaki Kume; Takahiko Shimizu; Kazuhiro Irie
        Journal of Agricultural and Food Chemistry, 13 Sep. 2023, Peer-reviewed, Corresponding author
      • 神経疾患に対する核酸医薬：アプタマー医薬
        村上一馬
        脳神経内科, Jun. 2023, Invited
      • 腸内細菌生産天然物による創薬研究の新展開
        村上一馬
        アグリバイオ, May 2023, Invited
      • Lysine-targeting inhibition of amyloid β oligomerization by a green perilla-derived metastable chalcone in vitro and in vivo
        Kazuma Murakami; Yoshiki Sakaguchi; Kota Taniwa; Naotaka Izuo; Mizuho Hanaki; Taiji Kawase; Kenji Hirose; Takahiko Shimizu; Kazuhiro Irie
        RSC Chemical Biology, Oct. 2022, Peer-reviewed, Lead author, Corresponding author
      • Interactions of amyloid coaggregates with biomolecules and its relevance to neurodegeneration
        Kazuma Murakami; Kenjiro Ono
        The FASEB Journal, Sep. 2022, Peer-reviewed
        Access this paper :
      • Activity-differential search for amyloid-β aggregation inhibitors using LC-MS combined with principal component analysis
        Mizuho Hanaki; Kazuma Murakami; Hiroki Gunji; Kazuhiro Irie
        Bioorganic & Medicinal Chemistry Letters, Feb. 2022, Lead author, Corresponding author
      • Synthetic Biology-Based Discovery of Diterpenoid Pyrones from the Genome of Eupenicillium shearii
        Yohei Morishita; Kento Tsukada; Kazuma Murakami; Kazuhiro Irie; Teigo Asai
        Journal of Natural Products, 20 Jan. 2022
      • Aptamers targeting amyloidogenic proteins and their emerging role in neurodegenerative diseases
        Kazuma Murakami; Naotaka Izuo; Gal Bitan
        Journal of Biological Chemistry, Jan. 2022
        Access this paper :
      • Searching for Natural Products That Delay Nucleation Phase and Promote Elongation Phase of Amyloid β42 toward Alzheimer’s Disease Therapeutics
        Kazuma Murakami; Shiori Horii; Mizuho Hanaki; Kazuhiro Irie
        ACS Chemical Neuroscience, 31 Aug. 2021
      • Development of a Novel Alzheimer's Disease Model Based on the Theory of the Toxic-conformer of Amyloid β
        Naotaka Izuo; Takahiko Shimizu; Kazuma Murakami; Kazuhiro Irie
        YAKUGAKU ZASSHI, 01 Jun. 2021
      • Nucleic Acid Aptamer That Recognize Amyloid Protein: First RNA Aptamer Against Aβ42 Oligomer
        村上一馬; 入江一浩
        化学と生物, May 2021, Peer-reviewed, Invited, Lead author, Corresponding author
      • Synthetic and Biophysical Studies on the Toxic Conformer in Amyloid β with the E22Δ Mutation in Alzheimer Pathology.
        Kazuma Murakami; Tomomi Yamaguchi; Naotaka Izuo; Toshiaki Kume; Hideyuki Hara; Kazuhiro Irie
        ACS chemical neuroscience, 07 Oct. 2020
      • Detection of Amyloid β Oligomers with RNA Aptamers in AppNL-G-F/NL-G-F Mice: A Model of Arctic Alzheimer's Disease.
        Yayoi Obata; Kazuma Murakami; Taiji Kawase; Kenji Hirose; Naotaka Izuo; Takahiko Shimizu; Kazuhiro Irie
        ACS omega, 01 Sep. 2020
      • Synthetic and biochemical studies on the effect of persulfidation on disulfide dimer models of amyloid b42 at position 35 in Alzheimer's etiology
        Kazuma Murakami; a; Haruka Kato; Mizuho Hanaki; a; Yoko Monobe; Ken-ichi Akagi; Taiji Kawase; c; Kenji Hirosec; Kazuhiro Irie
        RSC Adv., May 2020, Peer-reviewed
        Access this paper :
      • Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones.
        Kento Tsukada; Shono Shinki; Akiho Kaneko; Kazuma Murakami; Kazuhiro Irie; Masatoshi Murai; Hideto Miyoshi; Shingo Dan; Kumi Kawaji; Hironori Hayashi; Eiichi N Kodama; Aki Hori; Emil Salim; Takayuki Kuraishi; Naoya Hirata; Yasunari Kanda; Teigo Asai
        Nature communications, 14 Apr. 2020, Peer-reviewed
        Access this paper :
      • An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer's disease.
        Kazuma Murakami; Yayoi Obata; Asa Sekikawa; Haruka Ueda; Naotaka Izuo; Tatsuya Awano; Keiji Takabe; Takahiko Shimizu; Kazuhiro Irie
        The Journal of biological chemistry, 10 Apr. 2020, Peer-reviewed
        Access this paper :
      • Synthesis and physicochemical properties of 20-mer peptide nucleic acid conjugates with testosterone 17β-carboxylic acid
        Ryotaro Yagita a; Kazuma Murakami a; Hisafumi Ikeda b; Kazuhiro Irie a
        Tetrahedron Letters, Apr. 2020, Peer-reviewed
      • Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model.
        Tomohiro Imamura; Yuki T Yanagihara; Yasumasa Ohyagi; Norimichi Nakamura; Kyoko M Iinuma; Ryo Yamasaki; Hirohide Asai; Masahiro Maeda; Kazuma Murakami; Kazuhiro Irie; Jun-Ichi Kira
        Neurobiology of disease, Apr. 2020, Peer-reviewed
      • Evaluation of Toxic Amyloid 42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator.
        Kazuma Murakami; Mayuko Yoshimura; Shota Nakagawa; Toshiaki Kume; Takayuki Kondo; Haruhisa Inoue; Kazuhiro Irie
        International journal of molecular sciences, 11 Feb. 2020, Peer-reviewed
      • An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease.
        Naotaka Izuo; Kazuma Murakami; Yoshitaka Fujihara; Masahiro Maeda; Takashi Saito; Takaomi C Saido; Kazuhiro Irie; Takahiko Shimizu
        Biochemical and biophysical research communications, 30 Jul. 2019, Peer-reviewed
      • Three Structural Features of Functional Food Components and Herbal Medicine with Amyloid β42 Anti-Aggregation Properties.
        Kazuma Murakami; Kazuhiro Irie
        Molecules (Basel, Switzerland), 05 Jun. 2019, Peer-reviewed, Invited
        Access this paper :
      • Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation.
        Yumi Irie; Mizuho Hanaki; Kazuma Murakami; Tsuneo Imamoto; Takumi Furuta; Takeo Kawabata; Taiji Kawase; Kenji Hirose; Yoko Monobe; Ken-Ichi Akagi; Ryo C Yanagita; Kazuhiro Irie
        Chemical communications (Cambridge, England), 20 Dec. 2018, Peer-reviewed
      • Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques.
        Yusuke Kageyama; Atsushi Saito; Olga Pletnikova; Gay L Rudow; Yumi Irie; Yang An; Kazuma Murakami; Kazuhiro Irie; Susan M Resnick; David R Fowler; Lee J Martin; Juan C Troncoso
        Scientific reports, 15 Nov. 2018, Peer-reviewed
      • Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers.
        Kazuma Murakami; Takuya Yoshioka; Shiori Horii; Mizuho Hanaki; Satohiro Midorikawa; Shinji Taniwaki; Hiroki Gunji; Ken-Ichi Akagi; Taiji Kawase; Kenji Hirose; Kazuhiro Irie
        Chemical communications (Cambridge, England), 14 Jun. 2018, Peer-reviewed
      • Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine.
        Mizuho Hanaki; Kazuma Murakami; Sumie Katayama; Ken-Ichi Akagi; Kazuhiro Irie
        Bioorganic & medicinal chemistry, 01 May 2018, Peer-reviewed
      • アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発
        泉尾直孝; 清水孝彦; 村上一馬; 入江一浩
        医薬品医療機器レギュラトリーサイエンス, 2018
      • A Toxic Conformer of Aβ42 with a Turn at 22-23 is a Novel Therapeutic Target for Alzheimer's Disease.
        Naotaka Izuo; Chihiro Kasahara; Kazuma Murakami; Toshiaki Kume; Masahiro Maeda; Kazuhiro Irie; Koutaro Yokote; Takahiko Shimizu
        Scientific reports, 18 Sep. 2017, Peer-reviewed
        Access this paper :
      • INHIBITORY ACTIVITY OF HISPIDIN DERIVATIVES ISOLATED FROM INONOTUS OBLIQUUS ON AMYLOID beta AGGREGATION
        Yukine Aihara; Ayumi Kawaguchi; Mizuho Hanaki; Kazuma Murakami; Kazuhiro Irie; Hideyuki Shigemori
        HETEROCYCLES, Jul. 2017, Peer-reviewed
      • Synthesized Aβ42 Caused Intracellular Oxidative Damage, Leading to Cell Death, via Lysosome Rupture.
        Yuki Oku; Kazuma Murakami; Kazuhiro Irie; Jun Hoseki; Yasuyoshi Sakai
        Cell structure and function, 23 May 2017, Peer-reviewed
      • Synthetic Models of Quasi-Stable Amyloid β40 Oligomers with Significant Neurotoxicity.
        Yumi Irie; Kazuma Murakami; Mizuho Hanaki; Yusuke Hanaki; Takashi Suzuki; Yoko Monobe; Tomoyo Takai; Ken-Ichi Akagi; Taiji Kawase; Kenji Hirose; Kazuhiro Irie
        ACS chemical neuroscience, 19 Apr. 2017, Peer-reviewed
      • 食品・生薬成分によるアミロイドβ42の凝集抑制機構の系統的解析
        K. Murakami; K. Irie
        日本認知症学会誌, 2017, Invited
      • Inhibitory Activities of Antioxidant Flavonoids from Tamarix gallica on Amyloid Aggregation Related to Alzheimer's and Type 2 Diabetes Diseases.
        Asma Ben Hmidene; Mizuho Hanaki; Kazuma Murakami; Kazuhiro Irie; Hiroko Isoda; Hideyuki Shigemori
        Biological & pharmaceutical bulletin, 2017, Peer-reviewed
      • STRUCTURE-ACTIVITY RELATIONSHIP OF PHENYLETHANOID GLYCOSIDES ON THE INHIBITION OF AMYLOID beta AGGREGATION
        Eri Kidachi; Manami Kurisu; Yusaku Miyamae; Mizuho Hanaki; Kazuma Murakami; Kazuhiro Irie; Hideyuki Shigemori
        HETEROCYCLES, Nov. 2016, Peer-reviewed
      • Semisynthesis and Structure-Activity Studies of Uncarinic Acid C Isolated from Uncaria rhynchophylla as a Specific Inhibitor of the Nucleation Phase in Amyloid β42 Aggregation.
        Takuya Yoshioka; Kazuma Murakami; Kyohei Ido; Mizuho Hanaki; Kanoko Yamaguchi; Satohiro Midorikawa; Shinji Taniwaki; Hiroki Gunji; Kazuhiro Irie
        Journal of natural products, 28 Oct. 2016, Peer-reviewed
      • Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer's disease diagnosis.
        Kazuma Murakami; Maki Tokuda; Takashi Suzuki; Yumi Irie; Mizuho Hanaki; Naotaka Izuo; Yoko Monobe; Ken-Ichi Akagi; Ryotaro Ishii; Harutsugu Tatebe; Takahiko Tokuda; Masahiro Maeda; Toshiaki Kume; Takahiko Shimizu; Kazuhiro Irie
        Scientific reports, 04 Jul. 2016, Peer-reviewed
        Access this paper :
      • Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids.
        Mizuho Hanaki; Kazuma Murakami; Ken-ichi Akagi; Kazuhiro Irie
        Bioorganic & medicinal chemistry, 15 Jan. 2016, Peer-reviewed
      • Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region.
        Kazuma Murakami; Takashi Suzuki; Mizuho Hanaki; Yoko Monobe; Ken-Ichi Akagi; Kazuhiro Irie
        Biochemical and biophysical research communications, 23 Oct. 2015, Peer-reviewed
      • Pathophysiological activities of the "toxic conformer" and the "non-toxic conformer" of amyloid beta-induced neurotoxicity
        Izuo Naotaka; Kume Toshiaki; Murakami Kazuma; Irie Kazuhiro; Izumi Yasuhiko; Akaike Akinori; Yokote Koutaro; Shimizu Takahiko
        JOURNAL OF PHARMACOLOGICAL SCIENCES, Jul. 2015, Peer-reviewed
      • アルツハイマー病様神経毒性におけるアミロイドβコンホマーの役割
        泉尾直孝; 村上一馬; 久米利明; 前田雅弘; 入江一浩; 清水孝彦
        基礎老化研究, 2015, Invited
      • Potential Role of Vitamin C in the Prevention of Alzheimer's Disease
        Kazuma Murakami; Kazuhiro Irie; Takahiko Shimizu
        Diet and Nutrition in Dementia and Cognitive Decline, 18 Nov. 2014, Peer-reviewed
      • Induction of Oxidative stress by the "toxic conformer" is crucial for A beta 42
        Izuo Naotaka; Kume Toshiaki; Murakami Kazuma; Sato Mizuho; Irie Kazuhiro; Izumi Yasuhiko; Akaike Akinori; Yokote Koutaro; Shimizu Takahiko
        JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Peer-reviewed
      • Conformation-specific antibodies to target amyloid β oligomers and their application to immunotherapy for Alzheimer's disease.
        Kazuma Murakami
        Bioscience, biotechnology, and biochemistry, 2014, Peer-reviewed
      • Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy for Alzheimer's disease.
        Naotaka Izuo; Kazuma Murakami; Mizuho Sato; Mami Iwasaki; Yasuhiko Izumi; Takahiko Shimizu; Akinori Akaike; Kazuhiro Irie; Toshiaki Kume
        Biochemical and biophysical research communications, 16 Aug. 2013, Peer-reviewed
      • Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues.
        Mizuho Sato; Kazuma Murakami; Mayumi Uno; Yu Nakagawa; Sumie Katayama; Ken-ichi Akagi; Yuichi Masuda; Kiyonori Takegoshi; Kazuhiro Irie
        The Journal of biological chemistry, 09 Aug. 2013, Peer-reviewed
      • Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity.
        Hiroaki Kamachi; Keisuke Tanaka; Ryo C Yanagita; Akira Murakami; Kazuma Murakami; Harukuni Tokuda; Nobutaka Suzuki; Yu Nakagawa; Kazuhiro Irie
        Bioorganic & medicinal chemistry, 15 May 2013, Peer-reviewed
      • Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness.
        Takayuki Kondo; Masashi Asai; Kayoko Tsukita; Yumiko Kutoku; Yutaka Ohsawa; Yoshihide Sunada; Keiko Imamura; Naohiro Egawa; Naoki Yahata; Keisuke Okita; Kazutoshi Takahashi; Isao Asaka; Takashi Aoi; Akira Watanabe; Kaori Watanabe; Chie Kadoya; Rie Nakano; Dai Watanabe; Kei Maruyama; Osamu Hori; Satoshi Hibino; Tominari Choshi; Tatsutoshi Nakahata; Hiroyuki Hioki; Takeshi Kaneko; Motoko Naitoh; Katsuhiro Yoshikawa; Satoko Yamawaki; Shigehiko Suzuki; Ryuji Hata; Shu-Ichi Ueno; Tsuneyoshi Seki; Kazuhiro Kobayashi; Tatsushi Toda; Kazuma Murakami; Kazuhiro Irie; William L Klein; Hiroshi Mori; Takashi Asada; Ryosuke Takahashi; Nobuhisa Iwata; Shinya Yamanaka; Haruhisa Inoue
        Cell stem cell, 04 Apr. 2013, Peer-reviewed
      • Development of a platinum complex as an anti-amyloid agent for the therapy of Alzheimer's disease.
        Vijaya B Kenche; Lin W Hung; Keyla Perez; Irene Volitakes; Guiseppe Ciccotosto; Jeffrey Kwok; Nicole Critch; Nikki Sherratt; Mikhalina Cortes; Varsha Lal; Colin L Masters; Kazuma Murakami; Roberto Cappai; Paul A Adlard; Kevin J Barnham
        Angewandte Chemie (International ed. in English), 18 Mar. 2013, Peer-reviewed
      • Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation.
        Mizuho Sato; Kazuma Murakami; Mayumi Uno; Haruko Ikubo; Yu Nakagawa; Sumie Katayama; Ken-Ichi Akagi; Kazuhiro Irie
        Bioscience, biotechnology, and biochemistry, 2013, Peer-reviewed
      • Inhibition of amyloid β aggregation by acteoside, a phenylethanoid glycoside.
        Manami Kurisu; Yusaku Miyamae; Kazuma Murakami; Junkyu Han; Hiroko Isoda; Kazuhiro Irie; Hideyuki Shigemori
        Bioscience, biotechnology, and biochemistry, 2013, Peer-reviewed
      • Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease.
        Naoko Soejima; Yasumasa Ohyagi; Norimichi Nakamura; Eri Himeno; Kyoko M Iinuma; Nobutaka Sakae; Ryo Yamasaki; Takeshi Tabira; Kazuma Murakami; Kazuhiro Irie; Noriaki Kinoshita; Frank M LaFerla; Yutaka Kiyohara; Toru Iwaki; Jun-ichi Kira
        Current Alzheimer research, Jan. 2013, Peer-reviewed
      • Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-A beta APP mutation
        L. Kulic; J. McAfoose; T. Welt; C. Tackenberg; C. Spaeni; F. Wirth; V. Finder; U. Konietzko; M. Giese; A. Eckert; K. Noriaki; T. Shimizu; K. Murakami; K. Irie; S. Rasool; C. Glabe; C. Hock; R. M. Nitsch
        TRANSLATIONAL PSYCHIATRY, Nov. 2012, Peer-reviewed
      • Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein.
        Yusaku Miyamae; Manami Kurisu; Kazuma Murakami; Junkyu Han; Hiroko Isoda; Kazuhiro Irie; Hideyuki Shigemori
        Bioorganic & medicinal chemistry, 01 Oct. 2012, Peer-reviewed
      • Caffeoylquinic acids inhibit amyloid β fibril formation and cellular toxicity.
        Miyamae, Y; Kurisu, M; Murakami, K; Han, J; Isoda, H; Irie, K; Shigemori, H
        Bioorg. Med. Chem. 19 (1), 5844-5849 (2012)., Oct. 2012, Peer-reviewed
      • Toxicity in rat primary neurons through the cellular oxidative stress induced by the turn formation at positions 22 and 23 of Aβ42.
        Naotaka Izuo; Toshiaki Kume; Mizuho Sato; Kazuma Murakami; Kazuhiro Irie; Yasuhiko Izumi; Akinori Akaike
        ACS chemical neuroscience, 19 Sep. 2012, Peer-reviewed
      • Toxicity in Rat Primary Neurons through the Cellular Oxidative Stress Induced by the Turn Formation at Positions 22 and 23 of A beta 42
        Naotaka Izuo; Toshiaki Kume; Mizuho Sato; Kazuma Murakami; Kazuhiro Irie; Yasuhiko Izumi; Akinori Akaike
        ACS CHEMICAL NEUROSCIENCE, Sep. 2012, Peer-reviewed
      • SOD1の減少はアルツハイマー病様病態を早期に発症させる
        清水 孝彦; 村上 一馬; 村田 央; 野田 義博; 初田 裕幸; 村山 繁雄; 入江 一浩; 白澤 卓二
        日本抗加齢医学会総会プログラム・抄録集, Jun. 2012
      • Cytoplasmic superoxide radical: a possible contributing factor to intracellular Aβ oligomerization in Alzheimer disease.
        Kazuma Murakami; Takahiko Shimizu
        Communicative & integrative biology, 01 May 2012, Peer-reviewed
      • Geranyl modification on the tryptophan residue of ComXRO-E-2 pheromone by a cell-free system.
        Fumitada Tsuji; Ayako Ishihara; Keiko Kurata; Aya Nakagawa; Masahiro Okada; Shigeyuki Kitamura; Kyoko Kanamaru; Yuichi Masuda; Kazuma Murakami; Kazuhiro Irie; Youji Sakagami
        FEBS letters, 20 Jan. 2012, Peer-reviewed
      • Lack of the consensus sequence necessary for tryptophan prenylation in the ComX pheromone precursor.
        Fumitada Tsuji; Ayako Ishihara; Aya Nakagawa; Masahiro Okada; Shigeyuki Kitamura; Kyoko Kanamaru; Yuichi Masuda; Kazuma Murakami; Kazuhiro Irie; Youji Sakagami
        Bioscience, biotechnology, and biochemistry, 2012, Peer-reviewed
      • Crucial role of the turn at positions 22-23 in neurotoxicity of amyloid beta
        Izuo Naotaka; Kume Toshiaki; Sato Mizuho; Murakami Kazuma; Irie Kazuhiro; Izumi Yasuhiko; Akaike Akinori
        JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, Peer-reviewed
      • Aβの毒性ターン構造を認識する抗体
        村上一馬; 入江一浩
        神経内科, 2012, Invited
      • アミロイドβの「毒性コンホマー」形成とGlu22位における遺伝性変異
        村上一馬; 佐藤瑞穂; 鈴木啓之; 泉尾直孝; 久米利明; 赤池昭紀; 永田 徹; 西崎知之; 富山貴美; 森 啓; 入江一浩
        Dementia Japan,, 2012, Invited
      • Identification and biological activities of bryostatins from Japanese bryozoan.
        Sayo Ueno; Ryo C Yanagita; Kazuma Murakami; Akira Murakami; Harukuni Tokuda; Nobutaka Suzuki; Takeshi Fujiwara; Kazuhiro Irie
        Bioscience, biotechnology, and biochemistry, 2012, Peer-reviewed
      • ComX pheromone precursor contains no consensus sequence necessary for tryptophan prenylation.
        Tsuji, F; Ishihara, A; Kurata, K; Nakagawa, A; Okada, M; Kitamura, S; Kanamaru, K; Masuda, Y; Murakami, K; Irie, K; Sakagami, Y
        Biosci. Biotechnol. Biochem. 76 (8), 1492-1496 (2012)., 2012, Peer-reviewed
      • Stimulation of the amyloidogenic pathway by cytoplasmic superoxide radicals in an Alzheimer's disease mouse model.
        Kazuma Murakami; Nakaba Murata; Yoshihiro Noda; Kazuhiro Irie; Takuji Shirasawa; Takahiko Shimizu
        Bioscience, biotechnology, and biochemistry, 2012, Peer-reviewed
      • Preparation of stable amyloid β-protein oligomers of defined assembly order.
        Clark Rosensweig; Kenjiro Ono; Kazuma Murakami; Devin K Lowenstein; Gal Bitan; David B Teplow
        Methods in molecular biology (Clifton, N.J.), 2012, Peer-reviewed
      • SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease.
        Kazuma Murakami; Nakaba Murata; Yoshihiro Noda; Shoichi Tahara; Takao Kaneko; Noriaki Kinoshita; Hiroyuki Hatsuta; Shigeo Murayama; Kevin J Barnham; Kazuhiro Irie; Takuji Shirasawa; Takahiko Shimizu
        The Journal of biological chemistry, 30 Dec. 2011, Peer-reviewed
      • アルツハイマー病の分子治療戦略 新しい視点を求めて アミロイドβの毒性ターン構造を認識する抗体の開発
        入江 一浩; 村上 一馬; 増田 裕一; 村田 央; 野田 義博; 初田 裕幸; 村山 繁雄; 清水 孝彦; 堀越 優子; 木下 憲明; 白澤 卓二
        臨床神経学, Nov. 2011
      • [Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23].
        Kazuhiro Irie; Kazuma Murakami; Yuichi Masuda; Nakaba Murata; Yoshihiro Noda; Hiroyuki Hatsuta; Shigeo Murayama; Takahiko Shimizu; Yuko Horikoshi; Noriaki Kinoshita; Takuji Shirasawa
        Rinsho shinkeigaku = Clinical neurology, Nov. 2011, Peer-reviewed
      • Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice
        Kazuma Murakami; Shin-ichi Yokoyama; Nakaba Murata; Yusuke Ozawa; Kazuhiro Irie; Takuji Shirasawa; Takahiko Shimizu
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2011, Peer-reviewed
      • Formation of the 42-mer Amyloid β Radical and the Therapeutic Role of Superoxide Dismutase in Alzheimer's Disease.
        Kazuma Murakami; Takahiko Shimizu; Kazuhiro Irie
        Journal of amino acids, 2011, Peer-reviewed
      • Vitamin C restores behavioral deficits and amyloid-β oligomerization without affecting plaque formation in a mouse model of Alzheimer's disease.
        Kazuma Murakami; Nakaba Murata; Yusuke Ozawa; Noriaki Kinoshita; Kazuhiro Irie; Takuji Shirasawa; Takahiko Shimizu
        Journal of Alzheimer's disease : JAD, 2011, Peer-reviewed
      • E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity.
        Takayuki Suzuki; Kazuma Murakami; Naotaka Izuo; Toshiaki Kume; Akinori Akaike; Tetsu Nagata; Tomoyuki Nishizaki; Takami Tomiyama; Hiroshi Takuma; Hiroshi Mori; Kazuhiro Irie
        International journal of Alzheimer's disease, 19 Dec. 2010, Peer-reviewed
      • Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23.
        Kazuma Murakami; Yuko Horikoshi-Sakuraba; Nakaba Murata; Yoshihiro Noda; Yuichi Masuda; Noriaki Kinoshita; Hiroyuki Hatsuta; Shigeo Murayama; Takuji Shirasawa; Takahiko Shimizu; Kazuhiro Irie
        ACS chemical neuroscience, 17 Nov. 2010, Peer-reviewed
      • The turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide: the emerging role in the pathogenesis of Alzheimer's disease.
        Kazuma Murakami; Yuichi Masuda; Takuji Shirasawa; Takahiko Shimizu; Kazuhiro Irie
        Geriatrics & gerontology international, Jul. 2010, Peer-reviewed
      • Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model.
        Nakaba Murata; Kazuma Murakami; Yusuke Ozawa; Noriaki Kinoshita; Kazuhiro Irie; Takuji Shirasawa; Takahiko Shimizu
        Bioscience, biotechnology, and biochemistry, 2010, Peer-reviewed
      • RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity.
        Farid Rahimi; Kazuma Murakami; Jamie L Summers; Chi-Hong B Chen; Gal Bitan
        PloS one, 10 Nov. 2009, Peer-reviewed
      • Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative.
        Kazuma Murakami; Jun Inagaki; Mitsuru Saito; Yasutaka Ikeda; Chizuru Tsuda; Yoshihiro Noda; Satoru Kawakami; Takuji Shirasawa; Takahiko Shimizu
        Biochemical and biophysical research communications, 01 May 2009, Peer-reviewed
      • Isomerization and/or racemization at Asp23 of Abeta42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro.
        Kazuma Murakami; Mayumi Uno; Yuichi Masuda; Takahiko Shimizu; Takuji Shirasawa; Kazuhiro Irie
        Biochemical and biophysical research communications, 15 Feb. 2008, Peer-reviewed
      • Isomerization and/or racemization at Asp23 of A beta 42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro
        Kazuma Murakami; Mayumi Uno; Yuichi Masuda; Takahiko Shimizu; Takuji Shirasawa; Kazuhiro Irie
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2008, Peer-reviewed
      • βアミロイドの毒性コンホメーション
        村上 一馬; 清水 孝彦; 白澤 卓二; 入江 一浩
        化学と生物, 2008, Peer-reviewed
      • アミロイドβ (Aβ42) の毒性コンホメーションの提唱
        村上 一馬; 清水 孝彦; 白澤 卓二; 入江 一浩
        基礎老化研究, 2008, Peer-reviewed, Invited
      • Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: implications for the stronger neurotoxicity of Abeta42 than Abeta40.
        Kazuma Murakami; Hideyuki Hara; Yuichi Masuda; Hajime Ohigashi; Kazuhiro Irie
        Chembiochem : a European journal of chemical biology, 17 Dec. 2007, Peer-reviewed
      • The toxic conformation of the 42-residue amyloid β peptide and its relevance to oxidative stress in Alzheimer's disease
        K. Irie; K. Murakami; Y. Masuda; A. Morimoto; H. Ohigashi; H. Hara; R. Ohashi; K. Takegoshi; H. Fukuda; M. Nagao; T. Shimizu; T. Shirasawa
        Mini-Reviews in Medicinal Chemistry, Oct. 2007, Peer-reviewed
      • Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR.
        Yuichi Masuda; Kazuhiro Irie; Kazuma Murakami; Hajime Ohigashi; Ryutaro Ohashi; K Takegoshi; Takahiko Shimizu; Takuji Shirasawa
        Bioorganic & medicinal chemistry, 15 Dec. 2005, Peer-reviewed
      • Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR
        Y Masuda; K Irie; K Murakami; H Ohigashi; R Ohashi; K Takegoshi; T Shimizu; T Shirasawa
        BIOORGANIC & MEDICINAL CHEMISTRY, Dec. 2005, Peer-reviewed
      • Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease.
        Kazuma Murakami; Kazuhiro Irie; Hajime Ohigashi; Hideyuki Hara; Masaya Nagao; Takahiko Shimizu; Takuji Shirasawa
        Journal of the American Chemical Society, 02 Nov. 2005, Peer-reviewed
      • Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease.
        Kazuhiro Irie; Kazuma Murakami; Yuichi Masuda; Akira Morimoto; Hajime Ohigashi; Ryutaro Ohashi; Kiyonori Takegoshi; Masaya Nagao; Takahiko Shimizu; Takuji Shirasawa
        Journal of bioscience and bioengineering, May 2005, Peer-reviewed
      • Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement.
        Akira Morimoto; Kazuhiro Irie; Kazuma Murakami; Yuichi Masuda; Hajime Ohigashi; Masaya Nagao; Hiroyuki Fukuda; Takahiko Shimizu; Takuji Shirasawa
        The Journal of biological chemistry, 10 Dec. 2004, Peer-reviewed
      • Neurotoxicity and physicochemical properties of Abeta mutant peptides from cerebral amyloid angiopathy: implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease.
        Kazuma Murakami; Kazuhiro Irie; Akira Morimoto; Hajime Ohigashi; Mayumi Shindo; Masaya Nagao; Takahiko Shimizu; Takuji Shirasawa
        The Journal of biological chemistry, 14 Nov. 2003, Peer-reviewed
      • Neurotoxicity and physicochemical properties of A beta mutant peptides from cerebral amyloid angiopathy - Implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease
        K Murakami; K Irie; A Morimoto; H Ohigashi; M Shindo; M Nagao; T Shimizu; T Shirasawa
        JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2003, Peer-reviewed
      • Aggregation and neurotoxicity of mutant amyloid beta (A beta) peptides with proline replacement: importance of turn formation at positions 22 and 23.
        Akira Morimoto; Kazuhiro Irie; Kazuma Murakami; Hajime Ohigashi; Mayumi Shindo; Masaya Nagao; Takahiko Shimizu; Takuji Shirasawa
        Biochemical and biophysical research communications, 12 Jul. 2002, Peer-reviewed
      • Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23
        K Murakami; K Irie; A Morimoto; H Ohigashi; M Shindo; M Nagao; T Shimizu; T Shirasawa
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2002, Peer-reviewed

      Misc.

      • リアル学会での偶然から
        村上一馬
        内藤記念科学振興財団 時報 第108号, Sep. 2021, Invited
      • 33. Functional analysis of new peptide hormones that control stomatal formation
        Hirabayashi Tomomi; Sugita Taiga; Hokoyama Mayumi; Kondo Tatsuhiko; Murakami Kazuma; Irie Kazuhiro; Kakimoto Tatsuo; Sakagami Youji
        植物化学調節学会研究発表記録集, 03 Oct. 2011
      • アミロイドβのプロトフィブリルを認識するRNAアプタマー
        村上一馬
        第38回日本認知症学会学術集会（京王プラザホテル、東京）, Nov. 2020, Peer-reviewed
      • アミロイドβの凝集を抑制する食品・生薬成分の作用機構
        入江一浩; 村上一馬
        2019年度日本農芸化学会大会（東京農大、東京）, Mar. 2019
      • アミロイドβ42の毒性オリゴマーに対する核酸アプタマーの開発研究と脳組織染色への応用
        村上一馬
        2019年度日本農芸化学会大会（東京農大、東京）, Mar. 2019
      • 生合成経路の再構築と再設計による糸状菌ジテルペノイドピロンライブラリーの構築と生物活性評価
        塚田健人; 塚田健人; 金子秋穂; 新木翔之; 河治久実; 児玉栄一; 倉石貴透; 村上一馬; 入江一浩; 平田尚也; 諫田泰成; 浅井禎吾
        メディシナルケミストリーシンポジウム講演要旨集, 01 Nov. 2018
      • 生合成経路の再構築と再設計による糸状菌ジテルペノイドピロンライブラリーの構築と生物活性評価
        塚田健人; 塚田健人; 金子秋穂; 新木翔之; 河治久実; 児玉栄一; 倉石貴透; 村上一馬; 入江一浩; 平田尚也; 諫田泰成; 浅井禎吾
        メディシナルケミストリーシンポジウム講演要旨集, 01 Nov. 2018
      • RNA aptamers targeting the toxic oligomers of Aβ42 and their application to immunohistochemistry
        K. Murakami
        The 45th International Syposium on Nucleic Acids Chemistry (Kyoto University Clock Tower Centennial Hall) (Kyoto, Japan), Nov. 2018
      • 天然物によるアミロイドβの毒性オリゴマー形成阻害機構
        村上一馬
        第37回日本認知症学会学術集会（ロイトン札幌・札幌市教育文化会館、札幌市）, Oct. 2018
      • 生薬チョウトウコウに含まれるアミロイドβオリゴマー形成阻害物質の同定と作用機構
        村上一馬
        第59回天然有機化合物討論会（わくわくホリデーホール、札幌市）, Sep. 2017, Peer-reviewed
      • アミロイドβの毒性配座理論と抗体創製
        村上一馬; 入江一浩
        認知症研究を知る若手研究者の集まり2017（湯の宿木もれび、大津市）, Jul. 2017
      • アミロイドβ42の35番目でジスルフィド架橋したダイマーの合成と活性評価
        村上一馬
        2017年度日本農芸化学会大会（京都女子大学、京都市）, Mar. 2017
      • 天然ポリフェノールによるAβ42凝集阻害機構の解明とアルツハイマー病予防の可能性
        村上一馬; 入江一浩
        第35回日本認知症学会学術集会（東京国際フォーラム、東京都千代田区）, Dec. 2016, Invited
      • アミロイドβの毒性コンホマーにきわめて特異的な抗体の開発とアルツハイマー病診断への応用
        村上一馬
        2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市）, Mar. 2016
      • Characterization of the monoclonal antibody (24B3) highly recognizing the toxic turn of amyloid β42 and its application to diagnosis for Alzheimer’s disease
        K. Murakami
        The 8th Takeda Science Foundation Symposium on PharmaSciences “Biomolecule-based Medicinal Science: Featuring Mid-Size Drugs” (Takeda Pharmaceutical Company, Ltd.) (Suita, Japan), Jan. 2016
      • 神経細胞内に蓄積したAβ42が細胞死を引き起こす機構
        奥 勇紀; 村上 一馬; 入江 一浩; 寶関 淳; 阪井 康能
        日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015
      • Characterization of monoclonal antibodies against the toxic turn of amyloid β42 and their application to diagnosis for Alzheimer’s disease.
        K. Murakami
        2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA), Dec. 2015, Invited
      • アミロイドβの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用
        村上一馬; 入江一浩
        第8回たんぱく質の異常凝集とその防御・修復機構に関する研究会（京都大学原子炉実験所、熊取町）, Nov. 2015
      • アミロイドβの毒性コンホマーを極めて特異的に認識する抗体の開発とAD診断への応用
        村上一馬
        第34回日本認知症学会学術集会（リンクステーションホール青森）, Oct. 2015
      • アミロイドβペプチドの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用
        K. Murakami; K. Irie
        第47回若手ペプチド夏の勉強会、信州塩尻・天然温泉アスティかたおか（塩尻市）, Aug. 2015, Invited
      • 神経細胞内に蓄積したAβ42による細胞毒性の発現機構
        奥勇紀; 村上一馬; 入江一浩; 寶関淳; 阪井康能
        日本農芸化学会大会講演要旨集(Web), 05 Mar. 2015
      • 青じそ由来化合物DDC のAβ誘発神経毒性に対する保護作用
        岩崎真実; 泉安彦; 村上一馬; 入江一浩; 赤池昭紀; 久米利明
        次世代を担う創薬・医療薬理シンポジウム2014, Aug. 2014
      • Inhibitors for Aβ42 aggregation in a traditional herbal medicine Uncaria rhynchophylla
        K. Murakami
        Alzheimer’s Association International Conference (Bella Center A/S, Copenhagen, Denmark), Jul. 2014, Peer-reviewed
      • Aβ42誘発神経毒性には「毒性コンホマー」による酸化ストレスの誘導が重要である
        泉尾直孝; 久米利明; 村上一馬; 佐藤瑞穂; 入江一浩; 泉安彦; 赤池昭紀; 横手幸太郎; 清水孝彦
        第87回日本薬理学会年会, Mar. 2014
      • 伝統生薬チョウトウコウに含まれるアミロイドβ凝集抑制物質
        村上一馬
        2014年度日本農芸化学会大会（東京）, Mar. 2014
      • 神経細胞内に蓄積したAβ42による細胞毒性の発症機構
        奥勇紀; 村上一馬; 入江一浩; 寳関淳; 阪井康能
        日本分子生物学会年会プログラム・要旨集(Web), 2014
      • 食品由来カフェオイルキナ酸の神経細胞保護効果
        繁森英幸; 宮前友策; 栗栖真奈美; 村上一馬; 入江一浩; Han Junkyu; 礒田博子
        日本機能性食品医用学会, Dec. 2013, Peer-reviewed
      • ポリフェノールによるアミロイドβ42の凝集抑制機構
        村上一馬
        第6回タンパク質の異常凝集とその防御・修復機構に関する研究会（京都大学原子炉実験所）, Nov. 2013
      • アルツハイマー病患者iPS細胞由来神経系細胞におけるAβオリゴマーの細胞毒性
        中野 梨絵; 浅井 将; 近藤 孝之; 月田 香代子; 渡邊 かおり; 門谷 千恵; 村上 一馬; 入江 一浩; Klein William L; 森 啓; 丸山 啓; 朝田 隆; 城谷 圭朗; 井上 治久; 岩田 修永
        Dementia Japan, Oct. 2013
      • Vitamin C and silymarin restores Aβ oligomerization and behavioral abnormality in Alzheimer’s pathology
        K. Murakami
        Alzheimer's Association International Conference (AAIC) 2013 in Boston, USA, Jul. 2013
      • ビタミンCによるアルツハイマー病態緩和
        村上一馬
        2013年度日本農芸化学会大会（仙台）, Mar. 2013
      • Cytoplasmic SOD Deficiency Promotes the Formation of Amyloid Beta Oligomer and Memory Impairment in a Mouse Model of Alzheimer's Disease
        Takahiko Shimizu; Kazuma Murakami; Hiroyuki Hatsuta; Shigeo Murayama; Kazuhiro Irie; Takuji Shirasawa
        FREE RADICAL BIOLOGY AND MEDICINE, Nov. 2012
      • アミロイドβオリゴマーの形成と空間記憶異常における細胞質SODの役割
        村上一馬
        第31回日本認知症学会学術集会, Oct. 2012
      • Aβ42“毒性コンホマー”の形成は細胞内酸化ストレスを誘導する
        泉尾直孝; 久米利明; 佐藤瑞穂; 村上一馬; 入江一浩; 泉安彦; 赤池昭紀
        次世代を担う創薬・医療薬理シンポジウム 2012, Sep. 2012
      • 17 Specific Inhibitory Mechanism of Aβ42 Aggregation by Catechol-Type Flavonoids(Oral Presentation)
        Murakami Kazuma; Sato Mizuho; Ikubo Haruko; Uno Mayumi; Nakagawa Yu; Katayama Sumie; Akagi Ken-ichi; Masuda Yuichi; Takegoshi Kiyonori; Irie Kazuhiro
        Symposium on the Chemistry of Natural Products, symposium papers, Sep. 2012, Peer-reviewed
      • Aβ42“毒性コンホマー”の形成による細胞内酸化ストレスの誘導
        泉尾直孝; 久米利明; 佐藤瑞穂; 村上一馬; 入江一; 泉安彦; 赤池昭紀
        第31回日本認知症学会学術集会, Jul. 2012
      • アミロイド β ペプチドの毒性ターン構造の同定とその構造特異抗体の開発
        村上一馬
        第47回天然物化学談話会, 熊本, Jul. 2012, Peer-reviewed
      • Monoclonal antibody against a toxic conformer of Aβ42 with a turn at E22-D23.
        Irie, K; Murakami, K; Kinoshita, N; Shirasawa, T; Shimizu, T; Tokuda, T
        Alzheimer’s Association International Conference 2012, Vancouver, Canada, Jul. 2012, Peer-reviewed
      • CuZn-SOD loss accelerates the formation of amyloid β oligomer and memory impairment in Tg2576 mice
        Murakami, K; Murata, N; Noda, Y; Tahara, S; Kaneko, T; Kinoshita, N; Hatsuta, H; Murayama, S; Barnham, Kevin J; Irie, K; Shirasawa, T; Shimizu, T
        Alzheimer’s Association International Conference, Vancouver, Canada, Jul. 2012, Peer-reviewed
      • 寄生植物由来化合物のアミロイドβ凝集阻害活性に関する研究
        栗栖真奈美; 宮前友策; 木立恵利; 村上一馬; Han Junkyu; 礒田博子; 入江一浩; 繁森英幸
        新規素材探索研究会, Jun. 2012
      • アミロイド β誘発神経毒性における 22,23位でのターン構造の重要性
        泉尾直孝; 久米利明; 佐藤瑞穂; 村上一馬; 入江一浩; 泉安彦; 赤池昭紀
        第 85回日本薬理学会年会, Mar. 2012
      • ヤセウツボ（Orobanche miner）由来化合物のアミロイドβ凝集阻害活性に関する研究
        栗栖真奈美; 宮前友策; 村上一馬; Han Junkyu; 礒田博子; 入江一浩; 繁森英幸
        日本農芸化学会2012年度大会, Mar. 2012
      • 細胞質酸化ストレスによるアミロイド β オリゴマー形成能および記憶異常の促進
        村上一馬; 村田 央; 野田義博; 田原正一; 金子孝夫; 木下憲明; 初田裕幸; 村山繁雄; 入江一浩; 白澤卓二; 清水孝彦
        日本農芸化学会2012年度大会, 京都, Mar. 2012, Peer-reviewed
      • 細胞質局在型SODの減少はアミロイドβオリゴマー形成と記憶障害を促進する
        清水孝彦; 清水孝彦; 村上一馬; 村上一馬; 村田央; 野田義博; 初田裕幸; 村山繁雄; 入江一浩; 白澤卓二
        日本分子生物学会年会プログラム・要旨集(Web), 2012
      • 固体NMRおよびESRによるアミロイドβの立体構造解析と毒性ターン構造特異抗体の開発
        村上 一馬; 増田 裕一; 入江 一浩
        遺伝子医学MOOK, 2012, Peer-reviewed, Invited
      • 抗酸化ストレスに着目したアルツハイマー病予防の可能性
        村上一馬
        原子炉実験所専門研究会（熊取）, Nov. 2011
      • 大阪変異によるアミロイド β の毒性コンホマー形成能の増大．
        村上一馬; 鈴木啓之; 泉尾直孝; 久米利明; 赤池昭紀; 永田 徹; 西崎知之; 富山貴美; 森 啓; 入江一浩
        第30回日本認知症学会学術集会, 東京., Nov. 2011, Peer-reviewed
      • Silymarin attenuated the amyloid β deposition and improved behavioral abnormalities in a mouse model of Alzheimer’s disease.
        Shimizu, T; Murakami, K; Murata, N; Ozawa, Y; Irie, K; Shirasawa, T
        41st Annual Meeting of Society for Neuroscience, Washington DC, USA, Nov. 2011, Peer-reviewed
      • カフェオイルキナ酸のアミロイドβ凝集阻害活性及び分子機構
        宮前友策; 栗栖真奈美; 村上一馬; 入江一浩; Han Junkyu; 礒田博子; 繁森英幸
        第52回天然有機化合物討論会, Sep. 2011, Peer-reviewed
      • Antibody against toxic conformer of Alzheimer β.
        Murakami, K; Horikoshi-Sakuraba, Y; Kinoshita, N; Shirasawa, T; Shimizu, T; Irie, K
        22nd French-Japanese Symposium on Medicinal and Fine Chemistry, Rouen, France, Sep. 2011, Peer-reviewed
      • Inhibitory mechanism of amyloid β aggregation by flavonoids.
        Sato, M; Murakami, K; Ikubo, H; Masuda, Y; Takegoshi, K; Irie, K
        27th International Symposium on the Chemistry of Natural Products (ISCNP27)/7th International Conference on Biodiversity (ICOB7), Brisbane, Australia, Jul. 2011, Peer-reviewed
      • E22Δ mutation promotes the oformation of toxic conformer in Alzheimer’s peptide, Aβ42.
        Murakami, K; Suzuki, T; Yamaguchi, T; Izuo, N; Kume, T; Akaike, A; Nagata, T; Nishizaki, T; Tomiyama, T; Takuma, H; Mori, H; Irie, K
        27th International Symposium on the Chemistry of Natural Products (ISCNP27)/7th International Conference on Biodiversity (ICOB7), Brisbane, Australia, Jul. 2011, Peer-reviewed
      • Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice.
        Kazuma Murakami; Shin-ichi Yokoyama; Nakaba Murata; Yusuke Ozawa; Kazuhiro Irie; Takuji Shirasawa; Takahiko Shimizu
        Biochemical and biophysical research communications, 27 May 2011, Peer-reviewed
      • アミロイド β のGlu22欠損による毒性コンホマー形成能の促進
        村上一馬; 鈴木啓之; 泉尾直孝; 久米利明; 赤池昭紀; 永田 徹; 西崎知之; 富山貴美; 森 啓; 入江一浩
        日本農芸化学会2011年度大会, 京都, Mar. 2011, Peer-reviewed
      • Monoclonal antibody against the toxic turn structure of the 42-mer amyloid β peptide.
        Murakami, K; Horikoshi-Sakuraba, Y; Murata, N; Noda, Y; Masuda, Y; Kinoshita, N; Hatsuta, H; Murayama, S; Shirasawa, T; Shimizu, T; Irie, K
        The 2010 International Chemical Congress of Pacific Basin Societies, Honolulu HI, USA, Dec. 2010, Peer-reviewed
      • アミロイド β の毒性ターン構造特異的抗体．
        村上一馬; 堀越優子; 村田 央; 野田義博; 増田裕一; 木下憲明; 初田裕幸; 村山繁雄; 白澤卓二; 清水孝彦; 入江一浩
        第29回日本認知症学会学術集会, 名古屋, Nov. 2010, Peer-reviewed
      • SilymarinによるADモデルマウスの行動異常及びAβ オリゴマー形成の改善．
        村上一馬; 村田 央; 小澤裕介; 木下憲明; 入江一浩; 白澤卓二; 清水孝彦
        日本農芸化学会2010年度関西支部大会, 大阪, Oct. 2010, Peer-reviewed
      • アミロイド β（Αβ42）の毒性コンホマー特異的抗体の作製
        村上一馬; 堀越優子; 村田 央; 野田義博; 増田裕一; 木下憲明; 初田裕幸; 村山繁雄; 白澤卓二; 清水孝彦; 入江一浩
        第52回天然有機化合物討論会, 静岡, Sep. 2010, Peer-reviewed
      • アミロイド β の毒性コンホマーを標的とした立体構造特異的抗体．
        村上一馬; 堀越優子; 村田 央; 野田義博; 増田裕一; 木下憲明; 初田裕幸; 村山繁雄; 白澤卓二; 清水孝彦; 入江一浩
        日本農芸化学会2010年度大会, 東京, Mar. 2010, Peer-reviewed
      • Silyamarin inhibits neurotoxicity and aggregation of the 42-mer amyloid-β peptide.
        村田 央; 村上一馬; 横山慎也; 入江一浩; 白澤卓二; 清水孝彦
        第32回日本分子生物学会年会, 横浜, Dec. 2009, Peer-reviewed
      • RNA Aptamers Generated against Oligomeric A beta 40 Recognize Common Amyloid Aptatopes with Low Specificity but High Sensitivity
        Farid Rahimi; Kazuma Murakami; Jamie L. Summers; Chi-Hong B. Chen; Gal Bitan
        PLOS ONE, Nov. 2009, Peer-reviewed
      • CuZn-SOD欠損マウスにおける皮膚の菲薄化およびコラーゲン形成異常.
        清水孝彦; 村上一馬; 稲垣 潤; 斎藤 充; 池田泰隆; 津田千鶴; 野田義博; 川上 哲; 白澤卓二
        第32回日本基礎老化学会年会, 横浜, Jun. 2009, Peer-reviewed
      • 細胞質SOD欠損マウスにおける皮膚の菲薄化.
        清水孝彦; 村上一馬; 稲垣 潤; 斎藤 充; 池田泰隆; 津田千鶴; 野田義博; 川上 哲; 白澤卓二
        第9回日本抗加齢医学会総会, May 2009, Peer-reviewed
      • アミロイドβのAsp23における異性化あるいはラセミ化が凝集能および神経細胞毒性に及ぼす影響
        村上一馬; 宇野真弓; 増田裕一; 清水孝彦; 白澤卓二; 入江一浩
        日本農芸化学会年2009年度大会, 福岡, Mar. 2009, Peer-reviewed
      • Development of a monoclonal antibody against the toxic conformer of the 42-mer amyloid β protein
        Kazuma Murakami
        39th Annual Meeting of Society for Neuroscience (Chicago, USA), 2009
      • β アミロイドの毒性コンホメーションのESRならびに固体NMRによる検証.
        入江一浩; 村上一馬; 増田裕一; 上村諭子; 原 英之; 中西 梓; 大橋竜太郎; 竹腰清乃理
        第27回日本認知症学会, 前橋, Oct. 2008, Peer-reviewed
      • Aptamers selected against monomeric Aβ40 recognize other amyloid proteins.
        Summers, J. L; Rahimi, F; Murakami, K; Bitan, G
        22nd Annual Symposium of the Protein Society, San Diego, USA, Jul. 2008, Peer-reviewed
      • アミロイド β ペプチド (Aβ42) の病的コンホメーションの提唱
        村上一馬; 増田裕一; 森本 晃; 宇野真弓; 原 英之; 清水孝彦; 白澤卓二; 入江一浩
        第31回日本基礎老化学会, 松本, Jun. 2008, Peer-reviewed
      • Isomerization and/or racemization at Asp23 of A beta 42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro
        Kazuma Murakami; Mayumi Uno; Yuichi Masuda; Takahiko Shimizu; Takuji Shirasawa; Kazuhiro Irie
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2008, Peer-reviewed
      • アミロイドβペプチドのターン構造形成とアスパラギン酸残基修飾
        清水孝彦; 村上一馬; 宇野真弓; 入江一浩; 白澤卓二
        第80回日本生化学会大会ワークショップ, Dec. 2007, Peer-reviewed
      • Distance analysis between Tyr-10 and Met-35 in amyloid β using site-directed spin labeling ESR: implications for the stronger neurotoxicity of Aβ42 than Aβ40.
        Murakami, K; Hara, H; Irie, K
        37th Annual Meeting of Society for Neuroscience, San Diego, CA, USA, Nov. 2007, Peer-reviewed
      • 固体NMRならびにESRによるアミロイド β (Aβ42) の毒性コンホメーションの解析.
        入江一浩; 増田裕一; 村上一馬; 上村諭子; 原 英之; 大橋竜太郎; 中西 梓; 竹腰清乃理
        第 49回天然有機化合物討論会, 北海道, Sep. 2007, Peer-reviewed
      • ラジカル産生を介した β アミロイドの神経細胞毒性発現機構.
        村上一馬
        日本農芸化学会 2007年度大会, 東京, Mar. 2007, Peer-reviewed
      • ‘Malignant’ conformation of Alzheimer’s β peptides (Aβ42) through radical formation.
        Murakami, K; Irie, K; Ohigashi, H; Hara, H; Nagao, M; Shimizu, T; Shirasawa, T
        International Conference of 43rd Japanese Peptide Symposium, Yokohama, Japan, Nov. 2006, Peer-reviewed
      • Elucidation of the ‘malignant’ conformation of β-amyloid with Italian mutation (E22K-Aβ42) using solid-state NMR.
        Masuda, Y; Irie, K; Murakami, K; Ohigashi, H; Ohashi, R; Takegoshi, K
        ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products, Kyoto, Japan, Jul. 2006, Peer-reviewed
      • Formation and stabilization mechanism of the β-amyloid radical.
        Murakami, K; Irie, K; Ohigashi, H; Hara, H; Nagao, M; Shimizu, T; Shirasawa, T
        ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products, Jul. 2006, Peer-reviewed
      • Application of dipolar-assisted rotational resonance (DARR) to β-amyloid.
        Masuda, Y; Irie, K; Murakami, K; Ohigashi, H; Ohashi, R; ○Takegoshi, K
        The 2005 International Chemical Congress of Pacific Basin Societies, Honolulu, USA, Dec. 2005, Peer-reviewed
      • Elucidation of the ‘malignant’ conformation of β-amyloid with Italian mutation (E22K-Aβ42) using solid-state NMR: implications for the pathogenesis of cerebral amyloid angiopathy and Alzheimer’s disease.
        Masuda, Y; Irie, K; Murakami, K; Ohigashi, H; Ohashi, R; Takegoshi, K; Shimizu, T; Shirasawa, T
        35th Annual Meeting of Society for Neuroscience, Washington DC, USA, Nov. 2005, Peer-reviewed
      • New aggregation model of 42-mer amyloid β by the systematic proline replacement.
        Irie, K; Murakami, K; Masuda, Y; Morimoto, A; Ohigashi, H; Hara, H; Nagao, M; Shimizu, T; Shirasawa, T
        35th Annual Meeting of Society for Neuroscience, Washington DC, USA, Nov. 2005, Peer-reviewed
      • Alzheimer’s 42-mer β peptide-specific mechanism of neurotoxicity through radical formation.
        Murakami, K; Irie, K; Ohigashi, H; Hara, H; Nagao, M; Shimizu, T; Shirasawa, T
        35th Annual Meeting of Society for Neuroscience, Washington DC, USA, Nov. 2005, Peer-reviewed
      • β アミロイドの新しい凝集モデルに基づく神経細胞毒性発現機構.
        村上一馬; 入江一浩; 森本 晃; 増田裕一; 大東 肇; 永尾雅哉; 清水孝彦; 白澤卓二
        第 47回天然有機化合物討論会, 徳島, Oct. 2005, Peer-reviewed
      • Aβ42 ラジカルの生成と神経細胞毒性発現機構.
        村上一馬
        第 24 回日本認知症学会, 大阪, Sep. 2005, Peer-reviewed
      • 系統的プロリン置換による β アミロイドフィブリルの2次構造解析
        村上一馬
        日本農芸化学会 2005 年度大会, 札幌, Mar. 2005, Peer-reviewed
      • Structural analysis of amyloid β.
        Ohashi, R; Takegoshi, K; Terao, T; Masuda, Y; Murakami, K; Irie, K
        XXI International Conference on Magnetic Resonance in Biological Systems, (Hyderabad, Andhra Pradesh, India),, Jan. 2005
      • New aggregation model of amyloid β by the systematic proline replacement.
        Murakami, K; Irie, K; Morimoto, A; Masuda, Y; Ohigashi, H; Nagao, M; Fukuda, H; Shimizu, T; Shirasawa, T
        1st Asia-Pacific International Peptide Symposium, 41st Japanese Peptide Symposium, Fukuoka, Japan, Nov. 2004, Peer-reviewed
      • β アミロイド (Aβ42) の新しい凝集モデル
        村上一馬
        第 37 回若手ペプチド夏の勉強会, 京都, Aug. 2004, Peer-reviewed
      • プロリン置換による Aβ42 凝集体の立体構造解析.
        村上一馬
        日本農芸化学会 2004 年度大会, 広島, Mar. 2004, Peer-reviewed
      • β アミロイドの新しい凝集モデル
        村上一馬
        第 22 回日本認知症学会, Oct. 2003, Peer-reviewed
      • β アミロイドの新しい凝集仮説.
        村上一馬
        第 38 回天然物化学談話会, 福岡, Jul. 2003, Peer-reviewed
      • 家族性アルツハイマー病因 β アミロイドの凝集活性および神経細胞毒性.
        村上一馬
        日本農芸化学会 2003 年度大会, 東京, Apr. 2003, Peer-reviewed
      • 家族性アルツハイマー病因ペプチドの化学合成、凝集活性および神経細胞毒性
        村上一馬
        第 37 回天然物化学談話会, 京都, Jul. 2002, Peer-reviewed
      • Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23.
        Kazuma Murakami; Kazuhiro Irie; Akira Morimoto; Hajime Ohigashi; Mayumi Shindo; Masaya Nagao; Takahiko Shimizu; Takuji Shirasawa
        Biochemical and biophysical research communications, 31 May 2002, Peer-reviewed
      • 家族性アルツハイマー β ペプチドの合成、凝集活性および神経細胞毒性.
        村上一馬
        日本農芸化学会 2002 年度大会, 仙台, Mar. 2002, Peer-reviewed

      Presentations

      • リシン標的型凝集阻害剤：抗認知症薬としての展望
        村上一馬
        第42回日本認知症学会学術集会（シンポジウム27：新しい分析ツールでひも解く次代のmisfolding病研究）, 25 Nov. 2023, Invited
      • アミロイド疾患の分子標的治療を目指した核酸生物化学研究
        村上一馬
        第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会合同大会（シンポジウム：多様なアミロイド凝集体による神経変性メカニズムの解明）＊学術変革領域研究（B）「メタアグリゲートの超分子挙動と動的キャプチャー」との共催, 06 Jul. 2023, Invited
      • 核酸研究から見えてきた新たなAD病態：核酸アプタマー医薬の創製と応用
        村上一馬
        第64回日本神経学会学術大会（シンポジウム14：注目されているアルツハイマー病の新たな病態研究）, 01 Jun. 2023, Invited
      • メタアグリゲートに関する核酸生物化学研究
        村上一馬
        金沢大学脳神経内科第41回Neuroscience Seminar, 12 May 2023, Invited
      • アミロイド蛋白質を認識する核酸アプタマー
        村上一馬
        京都大学複合原子力科学専門研究会「第14回タンパク質の異常凝集とその防御・修復機構に関する研究会」, 10 Mar. 2023, Invited
      • アミロイドタンパク質を認識する核酸アプタマー
        村上一馬
        日本薬学会北陸支部特別講演会, 27 Jan. 2023, Invited
      • Development of RNA aptamers that recognizes amyloid key structures
        Kazuma Murakami
        UCLA Department of Neurology Seminar, 07 Nov. 2022, Invited
      • アミロイド凝集を阻害する天然物の論理的探索法
        村上一馬
        第19回ファンクショナルフード学会学術集会, 07 Jan. 2023, Invited
      • Synthesis of conformation-restricted analogues of amyloid persulfide toward their application to nucleic acid medicine
        Kazuma Murakami; Masayoshi Mochizuki; Taku Yoshiya; Naotaka Izuo
        Redox Week in Sendai2022 (The 12th International NO Conference & The 22nd NOSJ), 30 Oct. 2022
      • 超硫黄化アミロイドに特異的な核酸プローブとエクソソームを用いた高感度検出法の開発
        村上一馬
        学術変革領域研究（A）新興硫黄生物学が拓く生命原理変革（硫黄生物学）第２回領域会議, 06 Aug. 2022
      • アミロイドタンパク質を認識する核酸アプタマーの創製と応用
        村上一馬
        2022年度日本農芸化学会オンラインシンポジウム, 17 Mar. 2022
      • Classification of amyloid β aggregation inhibitors from natural product library
        Kazuma Murakami; Shiori Horii; Tatsuto Sadamitsu; Yoshiki Sakaguchi; Kota Taniwa; Mizuho Hanaki; Hiroki Gunji; Kazuhiro Irie
        Pacifichem2020, 22 Dec. 2021
      • アミロイドタンパク質を認識するRNAアプタマーの治療・診断応用に向けて〜"アミロイド結合性核酸"の創薬応用〜
        村上一馬; 小畑弥生; 入江一浩
        27 Jun. 2021
      • アミロイドβ42の毒性オリゴマーを認識するRNAアプタマーの開発
        村上一馬; 小畑弥生; 関川あさ; 上田遥; 川瀬泰司; 廣瀬賢治; 泉尾直孝; 清水孝彦; 入江一浩
        第62回天然有機化合物討論会, 24 Sep. 2020
      • アミロイドβの凝集を抑える天然物の3つの特徴
        村上一馬
        日本食品科学工学会関西支部大会, 26 Oct. 2019, Invited
      • Session Chairs of Molecular and Cell Biology: Aβ/amyloid (O3-01-01~06)
        Kazuma Murakami; Lucía Chávez-Gutiérrez
        Alzheimer's Association International Conference 2019, 16 Jul. 2019
      • Strategy for development of RNA aptamers that target the toxic oligomer of Aβ42
        Murakami, K; Obata, Y; Sekikawa, A; Ueda, H; Izuo, N; Awano, T; Takabe, K; Shimizu, T; Irie, K
        Alzheimer's Association International Conference 2019, 16 Jul. 2019
      • Strategy for development of RNA aptamers targeting the toxic oligomer of Aβ42: toward prevention of oligomeropathy
        村上 一馬
        UCLA Mini-symposium "Oligomers in Alzheimer's disease: Elucidation of disease mechanisms and development of therapeutics", 12 Jul. 2019
      • RNA aptamers targeting the toxic oligomers of Aβ42 and their application to immunohistochemistry
        Kazuma Murakami; Yayoi Obata; Asa Sekikawa; Haruka Ueda; Naotaka Izuo; Tatsuya Awano; Keiji Takabe; Takahiko Shimizu; Kazuhiro Irie
        The 45th International Syposium on Nucleic Acids Chemistry, 07 Nov. 2018, Invited
      • Inhibitory mechanism of amyloid β42 aggregation by traditional herbal medicine and functional food components.
        Kazuma Murakami
        Zhejiang University–Kyoto University Joint Workshop, 27 Nov. 2017, Invited
      • オリゴマー仮説の視点からバイオマーカーを考える：アミロイドβの毒性配座理論
        村上一馬
        第36回日本認知症学術集会, 24 Nov. 2017, Invited
      • アミロイドβの毒性配座理論と抗体創製
        村上一馬
        認知症研究を知る若手研究者の集まり2017, 29 Jul. 2017, Invited
      • アミロイドβの毒性配座抗体とその診断応用
        村上一馬
        筑波大学特別講義（天然有機化合物と創薬R&D）, 05 Dec. 2016, Invited
      • 天然ポリフェノールによるAβ42凝集阻害機構の解明とアルツハイマー病予防の可能性
        村上一馬
        第35回日本認知症学術集会, 03 Dec. 2016, Invited
      • アミロイドβのラジカル化：アルツハイマー病態におけるSOD1の役割
        村上一馬
        第11回レドックス・ライフイノベーションシンポジウム, 17 Mar. 2016, Invited
      • アミロイドβの抗毒性コンホマー抗体とその診断応用の可能性
        村上一馬
        昭和大学学士会後援セミナー, 16 Mar. 2016, Invited
      • Characterization of monoclonal antibodies against the toxic turn of amyloid β42 and their application to diagnosis for Alzheimer's disease.
        Kazuma Murakami; Mizuho Hanaki; Maria Luisa Moro; Giorgio Giaccone; Fabrizio Tagliavini; Ken-ichi Akagi; Ryotaro Ishii; Takahiko Tokuda; Masahiro Maeda; Naotaka Izuo; Takahiko Shimizu; Kazuhiro Irie
        2015 International Chemical Congress of Pacific Basin Societies (PACICHEM 2015), 15 Dec. 2015, Invited
      • アミロイドβの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用
        村上一馬
        京都大学原子炉実験所専門研究会「第8回タンパク質の異常凝集とその防御・修復機構に関する研究会」, 19 Nov. 2015, Invited
      • アミロイドβペプチドの毒性配座理論に基づいた立体構造特異抗体の開発と診断薬への応用
        村上一馬
        第47回若手ペプチド夏の勉強会, 11 Aug. 2015, Invited
      • アミロイドβペプチドの毒性コンホマー特異抗体の開発と診断薬への応用
        村上一馬
        第50回天然物化学談話会, 02 Jul. 2015, Invited
      • 認知症の食品予防に関する化学的研究
        村上一馬
        京都大学オープンキャンパス2015, 02 Jul. 2015, Invited
      • アミロイドβを標的としたアルツハイマー病の新しい治療戦略
        村上一馬
        日本農芸化学会中部支部第172回例会, 22 Nov. 2014, Invited
      • アミロイドβの毒性オリゴマー認識薬開発への挑戦
        村上一馬
        日本農芸化学会関西支部例会（第483回講演）, 01 Mar. 2014, Invited
      • 酸化ストレスに着目したアミロイドβペプチドの神経細胞毒性発現機構
        村上一馬
        新学術領域天然物ケミカルバイオロジー「化学と生物学の壁と打開策：次世代天然物ケミカルバイロジー研究の開拓へ」地区ミニシンポジウム, 01 Feb. 2014, Invited
      • ポリフェノールによるアミロイドβの凝集抑制メカニズム
        村上一馬
        京都大学原子炉実験所専門研究会「第6回タンパク質の異常凝集とフォールディング病」, 13 Nov. 2013, Invited
      • ポリフェノールによるアミロイドβの凝集阻害機構
        村上一馬
        生理化学研究ユニット第3回シンポジウム, 02 Jul. 2013, Invited
      • 抗酸化ストレスに着目したアルツハイマー病予防の可能性
        京都大学原子炉実験所専門研究会「タンパク質の異常凝集とフォールディング病」, 10 Nov. 2011, 京都大学原子炉実験所
      • アミロイドβ異常凝集における「折れ曲がり」の役割
        京都大学原子炉実験所専門研究会 「タンパク質の異常凝集とフォールディング病」, 12 Nov. 2010, 京都大学原子炉実験所(大阪)
      • アルツハイマー病と機能性食品因子 （Alzheimer’s disease and functional foods）
        Invited Lecturer in Gwangju University, 13 Oct. 2010, Gwangju大学 (Gwangju, 韓国)
      • Structural analysis of toxic conformer of 42-mer amyloid β peptide using ESR spectrometry
        7th Asia-Pacific EPR/ESR Symposium, 12 Oct. 2010, Convention Center (Jeju, 韓国)
      • Development of a monoclonal antibody against the toxic conformer of the 42-mer amyloid β protein.
        Kazuma Murakami; Yuko Horikoshi-Sakuraba; Nakaba Murata; Yoshihiro Noda; Yuichi Masuda; Noriaki Kinoshita; Hiroyuki Hatsuta; Shigeo Murayama; Takuji Shirasawa; Takahiko Shimizu; Kazuhiro Irie
        39th Annual Meeting of Society for Neuroscience (Chicago), 18 Oct. 2009, Invited
      • ‘Toxic’ turn formation at positions 22 and 23 in Aβ42 and its relevance to oxidative stress in AD
        Neurodegeneration Research Meeting, 14 Aug. 2009, Melbourne大学 (Melbourne, Australia)

      Books and Other Publications

      • 実験医学増刊Vol.41, No.12「いま新薬で加速する神経変性疾患研究」
        村上一馬, Contributor, 第1章タンパク質構造と病態（1ー 2：アミロイドの核形成過程の制御分子群）
        羊土社, Jul. 2023
        Find Kyoto University's collection of books :
      • New Tide of Natural Product Chemistry
        Kazuma Murakami, Contributor, Part IV New Approach for Drug Discovery Using Natural Products; Chapter 15 High-Throughput Searches for Natural Products as Aggregation Modulators of Amyloidogenic Proteins
        Springer Singapore, 20 Jun. 2023
        Find Kyoto University's collection of books :
      • アミロイドβの「毒性コンホマー」形成とGlu22における遺伝性変異．
        村上一馬; 佐藤瑞穂; 鈴木啓之; 泉尾直孝; 久米利明; 赤池昭紀; 永田 徹; 西崎知之; 富山貴美; 森 啓; 入江一浩, Single work
        Dementia Japan 26 (3), 311-318 (2012)., 2012, Not refereed
      • アミロイド β の毒性ターン構造を認識する抗体の開発
        村上一馬; 入江一浩, Single work
        神経内科 77 (2), 179-184 (2012)., 2012, Not refereed
      • Cytoplasmic superoxide radicals as contributing factors to intracellular Aβ oligomerization in Alzheimer’s disease
        Murakami, K; Shimizu, T, Single work
        Commun. Integr. Biol. 5 (3), 255-258 (2012)., 2012, Not refereed
      • 固体NMRおよびESRによるアミロイド β の立体構造解析と毒性ターン構造特異抗体の開発.
        村上一馬; 増田裕一; 入江一浩, Single work
        遺伝子医学MOOK「最新ペプチド合成技術とその創薬研究への応用」 21, 211-216 (2012), 2012, Not refereed
      • 抗酸化ストレスに着目したアルツハイマー病予防の可能性.
        村上一馬; 入江一浩; 清水孝彦, Single work
        タンパク質の異常凝集とその防御・修復機構に関する研究会報告, 4, 10-14 (2011)., 2011, Not refereed
      • アミロイド β の毒性ターン構造を認識する抗体の開発.
        入江一浩; 村上一馬; 増田裕一; 村田 央; 野田義博; 初田裕幸; 村山繁雄; 清水孝彦; 堀越優子; 木下憲明; 白澤卓二, Single work
        臨床神経 51 (3), 25-29 (2011)., 2011, Not refereed
      • Formation of the 42-mer amyloid β radical and the therapeutic role of superoxide dismutase in Alzheimer’s disease.
        Murakami, K; Shimizu, T; Irie, K, Single work
        J. Amino Acids 2011, doi: 10.4061/2011/654207 (2011)., 2011, Not refereed
      • アミロイドβ異常凝集における「折れ曲がり」の役割
        村上一馬; 入江一浩, Single work
        タンパク質の異常凝集とその防御・修復機構に関する研究会報告（III）, 2010, Not refereed
      • The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide: the merging role in the pathogenesis of Alzheimer’s disease.
        Murakami, K; Masuda; Y. Shirasawa, T; Shimizu, T; Irie, K, Single work
        Geriatr. Gerontol. Int. 10 (Suppl. 1), S169-S179 (2010)., 2010, Not refereed
      • Amyloids and protein aggregation – analytical methods.
        Li, H; Rahimi, F; Sinha, S; Maiti, P; Bitan, G; Murakami, K, Single work
        Encyclopedia Anal. Chem. doi: 10.1002/9780470027318.a9038 (2009)., 2009, Not refereed
      • アミロイド β (Aβ42) の毒性コンホメーションの提唱.
        村上一馬; 清水孝彦; 白澤卓二; 入江一浩, Single work
        基礎老化研究 32 (3), 25-29 (2008)., 2008, Not refereed
      • The toxic conformation of the 42-residue amyloid β peptide and its relevance to oxidative stress in Alzheimer’s disease.
        Irie, K; Murakami, K; Masuda, Y; Morimoto, A; Ohigashi, H; Hara, H; Ohashi, R; Takegoshi K; Fukuda, H; Nagao, M; Shimizu, T; Shirasawa, T, Single work
        Mini-Rev. Med. Chem. 7 (10), 1001-1008 (2007)., 2007, Not refereed
      • Young investigator’s competition in Yokohama ~‘Malignant conformation of Aβ42 peptide’.
        村上一馬, Single work
        PEPTIDE NEWSLETTER JAPAN 63 (1), 5-8 (2007)., 2007, Not refereed
      • ‘Malignant’ conformation of Alzheimer’s β peptides (Aβ42) through radical formation.
        Murakami, K; Irie, K; Ohigashi, H; Hara, H; Nagao, M; Shimizu, T; Shirasawa, T, Single work
        In Peptide Science 2006, eds. Ishida, H. & Mihara, H., The Japanese Peptide Society, 19-20 (2006)., 2006, Not refereed
      • Structure of β-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer’s disease.
        Irie, K; Murakami, K; Masuda, Y; Morimoto, A; Ohigashi, H; Ohashi, R; Takegoshi, K; Nagao, M; Shimizu, T; Shirasawa, T, Single work
        J. Biosci. Bioeng. 99 (5), 437-447 (2005)., 2005, Not refereed
      • New aggregation model of amyloid β by the systematic proline replacement.
        Murakami, K; Irie, K; Morimoto, A; Masuda, Y; Ohigashi, H; Nagao, M; Fukuda, H; Shimizu, T; Shirasawa, T, Single work
        In Peptide Science 2004, ed. Shimohigashi, Y., The Japanese Peptide Society, 179-182 (2005)., 2005, Not refereed

      Industrial Property Rights

      • 特願国際出願PCT/JP2024/4974, RNAアプタマー
        村上一馬
      • 特願2023—023603, RNAアプタマー
        村上一馬
      • 特願2014-251898,2015-104411, アミロイドβの22位及び23位のターン構造を極めて特異的に認識する抗体
        入江一浩; 村上一馬; 清水孝彦; 泉尾直孝; 清藤 勉
      • 特許US 8,710,193; CN ZL201080046483.9, 特願特願2009-239542,国際特許出願PCT/JP2010/006162, Antibody recognizing turn structure in amyloid β
        Irie, K; Murakami, K; Masuda, Y; Shimizu, T; Shirasawa, T; Seito, T
      • 特願2009-239542, アミロイドβのターン構造を認識する抗体
        入江一浩; 村上一馬; 増田裕一; 清水孝彦; 白澤卓二; 清藤 勉

      Awards

      • Aug. 2004
        日本ペプチド学会, 第37回若手ペプチド夏の勉強会最優秀発表賞
      • Oct. 2005
        第47回天然有機化合物討論会奨励賞
      • Jul. 2006
        IUPAC天然物化学国際会議ICOB-5&ISCNP-25 poster prize
      • Nov. 2006
        The Japanese Peptide Society, 第43回ペプチド討論会&第4回ペプチド工学国際会議若手奨励賞
      • Jun. 2008
        日本基礎老化学会, 第31回日本基礎老化学会奨励賞
      • Jun. 2008
        Japan Society for Biomedical Gerontology, 2010年度日本農芸化学会大会トピックス賞（共同受賞，筆頭発表者：村上一馬）
      • Sep. 2010
        第52回天然有機化合物討論会奨励賞
      • Jul. 2012
        第12回天然物談話会奨励賞
      • Mar. 2013
        Japan Society for Bioscience, Biotechnology, Agrochemistry, 2013年度農芸化学奨励賞
      • Mar. 2013
        日本農芸化学会, Biosci. Biotechnol. Biochem.誌論文賞（共同受賞，筆頭発表者：村上一馬）
      • Mar. 2013
        Japan Society for Bioscience, Biotechnology, Agrochemistry, 2013年度日本農芸化学会大会トピックス賞（共同受賞，筆頭発表者：村上一馬）
      • 30 Nov. 2018
        36th Medicinal Chemistry Symposium, DMC, PSJ in 2018, Award for Excellent Presentation, 36th Medicinal Chemistry Symposium, DMC, PSJ in 2018 (Collaboration)
      • Sep. 2016
        日本学術振興会, 科研費審査委員表彰
      • Apr. 2013
        日本農芸化学会, 2018年度日本農芸化学会大会トピックス賞（共同受賞，筆頭発表者：坂口嘉紀）
      • Mar. 2019
        日本農芸化学会, 2019年度日本農芸化学会大会ポスター発表選出（共同受賞，筆頭発表者：村上一馬）
      • Mar. 2020
        日本農芸化学会, 2020年度日本農芸化学会大会ポスター発表選出（共同受賞，筆頭発表者：村上一馬）
      • 30 Sep. 2016
        日本学術振興会, 平成28年度科研費　審査委員表彰

      External funds: Kakenhi

      • [Amyloid and protein] Comprehensive search and validation of meta-aggregates by molecular evolutionary method
        Grant-in-Aid for Transformative Research Areas (B)
        Transformative Research Areas, Section (III)
        Kyoto University
        村上 一馬
        From 01 Apr. 2023, To 31 Mar. 2026, Granted
        RNA結合タンパク質;アミロイド;神経変性疾患;計算科学;高速AFM;分子進化
        https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23H03852/
      • Supramolecular behavior and dynamic capture of meta-aggregates
        Grant-in-Aid for Transformative Research Areas (B)
        Transformative Research Areas, Section (III)
        Kyoto University
        村上 一馬
        From 01 Apr. 2023, To 31 Mar. 2026, Granted
        研究推進;若手支援;アウトリーチ;国際共同研究;女性活躍
        https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-23H03849/
      • Structural chemistry of intracellular recognition by nucleic acid aptamers and brain barrier permeation strategies for the treatment of neurodegenerative disease
        Grant-in-Aid for Scientific Research (B)
        Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
        Kyoto University
        村上 一馬
        From 01 Apr. 2023, To 31 Mar. 2027, Granted
        アプタマー;エクソソーム;神経変性疾患;NMR;ドラッグデリバリーシステム
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02093/
      • Supramolecular behavior and dynamic capture of metastable amyloid aggregates
        Grant-in-Aid for Transformative Research Areas (B)
        From 01 Apr. 2023, To 31 Mar. 2026
        https://kaken.nii.ac.jp/grant/KAKENHI-AREA-23B304/
      • Development of highly sensitive detection method for supersulfide amyloid using nucleic acid probe and exosome
        Grant-in-Aid for Transformative Research Areas (A)
        Transformative Research Areas, Section (III)
        Kyoto University
        村上 一馬
        From 16 Jun. 2022, To 31 Mar. 2024, Declined
        アプタマー;エクソソーム;神経変性疾患;超硫黄;核酸医薬;国際共同研究;ペプチド合成;診断薬
        https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22H05564/
      • International research project on nucleic acid aptamers and their exosome-based application to therapeutics for synucleinopathy
        Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
        Medium-sized Section 37:Biomolecular chemistry and related fields
        Kyoto University
        Kazuma Murakami
        From 27 Oct. 2020, To 31 Mar. 2023, Project Closed
        アプタマー;エクソソーム;神経変性疾患;計算科学;核酸医薬;ドラッグデリバリーシステム;αシヌクレイン;国際共同研究
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20KK0126/
      • Bioorganic studies on the genotoxicity of colibactin produced from human microbiome in colorectal cancer
        Grant-in-Aid for Scientific Research (C)
        Basic Section 38040:Bioorganic chemistry-related
        Kyoto University
        村上 一馬
        From 01 Apr. 2020, To 31 Mar. 2024, Granted
        腸内細菌;抗菌活性;天然物化学;コリバクチン;ヒューミマイシン;標的探索;プロバイオティクス;片利共生;大腸がん;有機合成化学
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K05849/
      • Very early diagnosis of Alzheimer's disease by the toxic oligomer specific antibody of amyloid beta
        Grant-in-Aid for Scientific Research (A)
        Medium-sized Section 37:Biomolecular chemistry and related fields
        Kyoto University
        入江 一浩
        From 01 Apr. 2019, To 31 Mar. 2024, Project Closed
        アルツハイマー病;アミロイドβ;毒性オリゴマー;有機化学;ジスルフィド架橋;２量体;脳神経疾患;抗体
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H00921/
      • Unified comprehension of chemical communication by natural PKC ligands and development of new medicinal seeds
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Science and Engineering
        Kyoto University
        Kazuhiro Irie
        From 30 Jun. 2017, To 31 Mar. 2022, Project Closed
        プロテインキナーゼＣ;発がんプロモーター;ホルボールエステル;アプリシアトキシン;機械学習;アロタケタール;HIV;アルツハイマー病;シグナル伝達;癌;有機化学;薬理学;酵素;プロテインキナーゼC;CH/π相互作用;マクラマイシン;ヒト免疫不全ウイルス;がん細胞増殖抑制
        https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-17H06405/
      • Structural organic chemistry in inhibitory mechanism of amyloid beta oligomerization
        Grant-in-Aid for Young Scientists (A)
        Kyoto University
        Kazuma Murakami
        From 01 Apr. 2016, To 31 Mar. 2020, Project Closed
        脳神経疾患;アルツハイマー病;有機合成化学;漢方生薬;オリゴマー;アミロイドβ;NMR;質量分析;有機化学;天然物バンク;生薬;代謝
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H06194/
      • Search for novel target molecules of intracellular amyloid beta
        Grant-in-Aid for Challenging Exploratory Research
        Kyoto University
        Kazuma Murakami
        From 01 Apr. 2015, To 31 Mar. 2017, Project Closed
        アルツハイマー病;アミロイドβ;オリゴマー;標的探索;MS/MS;シグナル伝達;ビオチン化;磁性ビーズ;siRNA
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K12744/
      • Novel Preventive Strategy for Alzheimer's Disease Based on the Toxic Conformation Theory of Amyloid beta
        Grant-in-Aid for Scientific Research (S)
        Kyoto University
        Kazuhiro Irie
        From 30 May 2014, To 31 Mar. 2019, Project Closed
        アルツハイマー病;アミロイドβ;毒性ターン;凝集;抗体;脳脊髄液;診断;フラボノイド;脳神経疾患;有機化学;核酸アプタマー;ノックインマウス;毒性オリゴマー;アルツハイマー;オリゴマー;神経細胞毒性
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26221202/
      • Identification of amyloid beta aggregation inhibitors in a traditional herbal medicine Uncaria rhynchophylla and their inhibitory mechanism
        Grant-in-Aid for Young Scientists (B)
        Kyoto University
        Kazuma MURAKAMI
        From 01 Apr. 2013, To 31 Mar. 2015, Project Closed
        アルツハイマー病;アミロイドβ;凝集;漢方生薬;単離構造決定;チョウトウコウ;トリテルペン;NMR;カギカズラ;構造決定;トリテルペノイド
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25850080/
      • 33S solid-state NMR analysis of methionine radical inducing cytotoxicity of amyloid-beta protein
        Grant-in-Aid for Young Scientists (B)
        Tohoku University
        YUICHI MASUDA
        From 01 Apr. 2012, To 31 Mar. 2014, Project Closed
        有機化学;アミロイド;固体NMR;硫黄;ラジカル
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24780108/
      • Development of RNA aptamer against toxic Aβ oligomer
        Grant-in-Aid for Scientific Research (C)
        Kyoto University
        Kazuma MURAKAMI
        From 01 Apr. 2010, To 31 Mar. 2013, Project Closed
        アルツハイマー病;アミロイド β;凝集;オリゴマー;アプタマー;RNA;アミロイドβ;核酸アプタマー;ジアミノピペリン酸;Huisgen反応;白金;プロドラッグ;フイスゲン反応;アジド;アルキン;細胞質SOD;スーパーオキシドラジカル;光親和性標識;ラジカル;酸化ストレス;ビタミンC;インスリン受容体
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22603006/
      • Development of medicinal seeds for Alzheimer's disease based on the structural analysis of toxic oligomers of amyloid beta
        Grant-in-Aid for Scientific Research (A)
        Kyoto University
        Kazuhiro IRIE
        From 01 Apr. 2009, To 31 Mar. 2014, Project Closed
        アルツハイマー病;アミロイドβ;凝集;毒性ターン;抗体;フラボノイド;オリゴマー;アルツハイマー;凝集抑制;カテコール;Aβ42;βアミロイド;タキシフォリン;プロテインキナーゼC;クルクミン;シナプス毒性;アプリシアトキシン;抗ターン抗体;毒性コンホマー;光アフィニティーラベリング
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21248015/
      • Supramolecular behavior and dynamic capture of metastable amyloid aggregates
        Grant-in-Aid for Transformative Research Areas (B)
        From 01 Apr. 2023, To 31 Mar. 2026
        https://kaken.nii.ac.jp/grant/KAKENHI-AREA-23B304/
      • Structural chemistry of intracellular recognition by nucleic acid aptamers and brain barrier permeation strategies for the treatment of neurodegenerative diseases
        Grant-in-Aid for Scientific Research (B)
        Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
        Kyoto University
        村上 一馬
        From 01 Apr. 2023, To 31 Mar. 2027, Granted
        核酸アプタマー;エクソソーム;神経変性疾患;NMR;ドラッグデリバリーシステム;アプタマー
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K26786/
      • Exploring supersulfide that mediates energy metabolism and redox signaling
        Grant-in-Aid for Scientific Research (S)
        Broad Section H
        Tohoku University
        赤池 孝章
        From 01 Apr. 2024, To 31 Mar. 2029, Granted
        超硫黄分子;超硫黄カテネーション;エネルギー代謝;過酸化脂質ラジカル;酸化ストレス
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24H00063/
      • 神経変性疾患における超硫黄化アミロイドの役割に関する国際共同研究
        Fund for the Promotion of Joint International Research (International Collaborative Research)
        Medium-sized Section 37:Biomolecular chemistry and related fields
        Kyoto University
        村上 一馬
        From 09 Sep. 2024, To 31 Mar. 2029, Adopted
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24KK0115/

      External funds: others

      • 腸内細菌由来⾮天然ペプチドによる感染症治療の標的探索
        第52回内藤記念科学振興財団奨励⾦
        From 01 Apr. 2021, To 31 Mar. 2022
        村上一馬
      • 生薬由来化合物をリードにしたアミロイドβオリゴマー特異的な 核磁気共鳴イメージングプローブの開発
        第37回松籟科学技術振興財団研究助成
        From 01 Oct. 2019, To 30 Sep. 2021
        村上一馬
      • Aβ毒性コンホマーの細胞内標的タンパク質
        2012年度上原記念生命科学財団研究奨励金
        From 01 Apr. 2013, To 31 Mar. 2014
        村上一馬
      • 光親和性標識法及び固体NMR法を用いたアミロイドβ凝集阻害機構の解明
        第22回加藤記念バイオサイエンス振興財団研究助成
        From 01 Apr. 2011, To 30 Mar. 2013
        村上一馬
      list
        Last Updated :2025/04/29

        Education

        Teaching subject(s)

        • From 01 Apr. 2024, To 31 Mar. 2025
          Basic Organic Chemistry I
          N347, Spring, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Advanced Course of Natural Products Chemistry
          GA26, Spring, Graduate School of Agriculture, 1
        • From 01 Apr. 2024, To 31 Mar. 2025
          Seminar on Organic Chemistry
          7315, Fall, Faculty of Agriculture, 1
        • From 01 Apr. 2024, To 31 Mar. 2025
          Seminar of Organic Chemistry in Life Science
          GF03, Spring, Graduate School of Agriculture, 1.5
        • From 01 Apr. 2024, To 31 Mar. 2025
          Seminar of Organic Chemistry in Life Science
          GF03, Fall, Graduate School of Agriculture, 1.5
        • From 01 Apr. 2024, To 31 Mar. 2025
          Experimental Course of Organic Chemistry in Life Science
          GG03, Fall, Graduate School of Agriculture, 3
        • From 01 Apr. 2024, To 31 Mar. 2025
          Experimental Course of Organic Chemistry in Life Science
          GG03, Spring, Graduate School of Agriculture, 3
        • From 01 Apr. 2024, To 31 Mar. 2025
          Laboratory Course in Organic Chemistry in Food Science
          7280, Spring, Faculty of Agriculture, 3
        • From 01 Apr. 2024, To 31 Mar. 2025
          Analytical Chemistry in Food Science
          7299, Spring, Faculty of Agriculture, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Basic Organic Chemistry I
          N347, Spring, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2023, To 31 Mar. 2024
          Advanced Course of Bioorganic Chemistry
          GA25, Spring, Graduate School of Agriculture, 1
        • From 01 Apr. 2023, To 31 Mar. 2024
          Seminar on Organic Chemistry
          7315, Fall, Faculty of Agriculture, 1
        • From 01 Apr. 2023, To 31 Mar. 2024
          Laboratory Course in Organic Chemistry in Food Science
          7280, Spring, Faculty of Agriculture, 3
        • From 01 Apr. 2023, To 31 Mar. 2024
          Seminar of Organic Chemistry in Life Science1
          GB13, Year-long, Graduate School of Agriculture, 3
        • From 01 Apr. 2023, To 31 Mar. 2024
          Seminar of Organic Chemistry in Life Science2
          GB14, Year-long, Graduate School of Agriculture, 3
        • From 01 Apr. 2023, To 31 Mar. 2024
          Experimental Course of Organic Chemistry in Life Science2
          GC14, Year-long, Graduate School of Agriculture, 6
        • From 01 Apr. 2023, To 31 Mar. 2024
          Experimental Course of Organic Chemistry in Life Science1
          GC13, Year-long, Graduate School of Agriculture, 6
        • From 01 Apr. 2023, To 31 Mar. 2024
          Analytical Chemistry in Food Science
          7299, Fall, Faculty of Agriculture, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Experimental Course of Organic Chemistry in Life Science1
          GC13, Year-long, Graduate School of Agriculture, 6
        • From 01 Apr. 2022, To 31 Mar. 2023
          Basic Organic Chemistry I
          N347, Spring, Institute for Liberal Arts and Sciences, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Advanced Course of Natural Products Chemistry
          GA26, Spring, Graduate School of Agriculture, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Laboratory Course in Organic Chemistry in Food Science
          7280, Spring, Faculty of Agriculture, 3
        • From 01 Apr. 2022, To 31 Mar. 2023
          Experimental Course of Organic Chemistry in Life Science2
          GC14, Year-long, Graduate School of Agriculture, 6
        • From 01 Apr. 2022, To 31 Mar. 2023
          Analytical Chemistry in Food Science
          7299, Fall, Faculty of Agriculture, 2
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar on Organic Chemistry
          7315, Fall, Faculty of Agriculture, 1
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar of Organic Chemistry in Life Science2
          GB14, Year-long, Graduate School of Agriculture, 3
        • From 01 Apr. 2022, To 31 Mar. 2023
          Seminar of Organic Chemistry in Life Science1
          GB13, Year-long, Graduate School of Agriculture, 3
        • From Apr. 2011, To Mar. 2012
          有機化学実験及び実験法
          Spring, 農学部
        • From Apr. 2011, To Mar. 2012
          生命有機化学
          Spring, 農学部
        • From Apr. 2011, To Mar. 2012
          食品有機化学III
          Fall, 農学部
        • From Apr. 2011, To Mar. 2012
          生命有機化学専攻実験
          農学研究科
        • From Apr. 2011, To Mar. 2012
          生命有機化学専攻演習
          農学研究科
        • From Apr. 2012, To Mar. 2013
          Organic Chemistry in Life Science
          Spring, 農学部
        • From Apr. 2012, To Mar. 2013
          Organic Chemistry in Food Science III
          Fall, 農学部
        • From Apr. 2012, To Mar. 2013
          Laboratory Course in Organic Chemistry in Food Science
          Spring, 農学部
        • From Apr. 2013, To Mar. 2014
          Organic Chemistry in Food Science III
          Fall, 農学部
        • From Apr. 2013, To Mar. 2014
          Organic Chemistry in Life Science
          Spring, 農学部
        • From Apr. 2013, To Mar. 2014
          Laboratory Course in Organic Chemistry in Food Science
          Spring, 農学部
        • From Apr. 2013, To Mar. 2014
          Seminar of Organic Chemistry in Life Science
          Year-long, 農学研究科
        • From Apr. 2013, To Mar. 2014
          Experimental Course of Organic Chemistry in Life Science
          Year-long, 農学研究科
        • From Apr. 2014, To Mar. 2015
          Organic Chemistry in Life Science
          Spring, 農学部
        • From Apr. 2014, To Mar. 2015
          Laboratory Course in Organic Chemistry in Food Science
          Spring, 農学部
        • From Apr. 2014, To Mar. 2015
          Analytical Chemistry in Food Science
          Fall, 農学部
        • From Apr. 2014, To Mar. 2015
          Organic Chemistry in Life Science
          Spring, 農学研究科
        • From Apr. 2014, To Mar. 2015
          Seminar of Organic Chemistry in Life Science
          Year-long, 農学研究科
        • From Apr. 2014, To Mar. 2015
          Experimental Course of Organic Chemistry in Life Science
          Year-long, 農学研究科
        • From Apr. 2015, To Mar. 2016
          Organic Chemistry in Life Science
          Spring, 農学部
        • From Apr. 2015, To Mar. 2016
          Experimental Course of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2015, To Mar. 2016
          Experimental Course of Organic Chemistry in Life Science
          Year-long, 農学研究科
        • From Apr. 2015, To Mar. 2016
          Seminar of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2015, To Mar. 2016
          Seminar of Organic Chemistry in Life Science
          Year-long, 農学研究科
        • From Apr. 2015, To Mar. 2016
          Analytical Chemistry in Food Science
          Fall, 農学部
        • From Apr. 2015, To Mar. 2016
          Laboratory Course in Organic Chemistry in Food Science
          Spring, 農学部
        • From Apr. 2016, To Mar. 2017
          Basic Organic Chemistry I
          Spring, 全学共通科目
        • From Apr. 2016, To Mar. 2017
          Natural Products Chemistry
          Spring, 農学部
        • From Apr. 2016, To Mar. 2017
          Organic Chemistry in Life Science
          Spring, 農学研究科
        • From Apr. 2016, To Mar. 2017
          Experimental Course of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2016, To Mar. 2017
          Experimental Course of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2016, To Mar. 2017
          Experimental Course of Organic Chemistry in Life Science
          Year-long, 農学研究科
        • From Apr. 2016, To Mar. 2017
          Seminar of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2016, To Mar. 2017
          Seminar of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2016, To Mar. 2017
          Seminar of Organic Chemistry in Life Science
          Year-long, 農学研究科
        • From Apr. 2016, To Mar. 2017
          Analytical Chemistry in Food Science
          Fall, 農学部
        • From Apr. 2016, To Mar. 2017
          Laboratory Course in Organic Chemistry in Food Science
          Spring, 農学部
        • From Apr. 2017, To Mar. 2018
          Basic Organic Chemistry I
          Spring, 全学共通科目
        • From Apr. 2017, To Mar. 2018
          Natural Products Chemistry
          Spring, 農学部
        • From Apr. 2017, To Mar. 2018
          Experimental Course of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2017, To Mar. 2018
          Experimental Course of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2017, To Mar. 2018
          Seminar of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2017, To Mar. 2018
          Seminar of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2017, To Mar. 2018
          Advanced Course of Bioorganic Chemistry
          Spring, 農学研究科
        • From Apr. 2017, To Mar. 2018
          Analytical Chemistry in Food Science
          Fall, 農学部
        • From Apr. 2017, To Mar. 2018
          Laboratory Course in Organic Chemistry in Food Science
          Spring, 農学部
        • From Apr. 2018, To Mar. 2019
          Basic Organic Chemistry I
          Spring, 全学共通科目
        • From Apr. 2018, To Mar. 2019
          Natural Products Chemistry
          Spring, 農学部
        • From Apr. 2018, To Mar. 2019
          Advanced Course of Natural Products Chemistry
          Spring, 農学研究科
        • From Apr. 2018, To Mar. 2019
          Experimental Course of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2018, To Mar. 2019
          Experimental Course of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2018, To Mar. 2019
          Seminar of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2018, To Mar. 2019
          Seminar of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2018, To Mar. 2019
          Outline of Physiological Chemistry
          Fall, 全学共通科目
        • From Apr. 2018, To Mar. 2019
          Analytical Chemistry in Food Science
          Fall, 農学部
        • From Apr. 2018, To Mar. 2019
          Laboratory Course in Organic Chemistry in Food Science
          Spring, 農学部
        • From Apr. 2019, To Mar. 2020
          Basic Organic Chemistry I
          Spring, 全学共通科目
        • From Apr. 2019, To Mar. 2020
          Seminar on Organic Chemistry
          Fall, 農学部
        • From Apr. 2019, To Mar. 2020
          Experimental Course of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2019, To Mar. 2020
          Experimental Course of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2019, To Mar. 2020
          Seminar of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2019, To Mar. 2020
          Seminar of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2019, To Mar. 2020
          Advanced Course of Bioorganic Chemistry
          Spring, 農学研究科
        • From Apr. 2019, To Mar. 2020
          Analytical Chemistry in Food Science
          Fall, 農学部
        • From Apr. 2019, To Mar. 2020
          Laboratory Course in Organic Chemistry in Food Science
          Spring, 農学部
        • From Apr. 2020, To Mar. 2021
          Basic Organic Chemistry I
          Spring, 全学共通科目
        • From Apr. 2020, To Mar. 2021
          Advanced Course of Natural Products Chemistry
          Spring, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar on Organic Chemistry
          Spring, 農学部
        • From Apr. 2020, To Mar. 2021
          Experimental Course of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Experimental Course of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Seminar of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2020, To Mar. 2021
          Analytical Chemistry in Food Science
          Fall, 農学部
        • From Apr. 2020, To Mar. 2021
          Laboratory Course in Organic Chemistry in Food Science
          Year-long, 農学部
        • From Apr. 2021, To Mar. 2022
          Basic Organic Chemistry I
          Spring, 全学共通科目
        • From Apr. 2021, To Mar. 2022
          Seminar on Organic Chemistry
          Fall, 農学部
        • From Apr. 2021, To Mar. 2022
          Experimental Course of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2021, To Mar. 2022
          Experimental Course of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2021, To Mar. 2022
          Seminar of Organic Chemistry in Life Science1
          Year-long, 農学研究科
        • From Apr. 2021, To Mar. 2022
          Seminar of Organic Chemistry in Life Science2
          Year-long, 農学研究科
        • From Apr. 2021, To Mar. 2022
          Advanced Course of Bioorganic Chemistry
          Spring, 農学研究科
        • From Apr. 2021, To Mar. 2022
          Analytical Chemistry in Food Science
          Fall, 農学部
        • From Apr. 2021, To Mar. 2022
          Laboratory Course in Organic Chemistry in Food Science
          Spring, 農学部

        Student achievements: Awards

        • 2018年度日本農芸化学会大会トピックス賞（共同）
          坂口嘉紀, 日本農芸化学会, 27 Mar. 2018

        Part-time lecturer

        • From 09 Apr. 2014, To 30 Sep. 2014
          天然物有機化学
          集中, 広島大学, 大学院理学研究科
        • From 08 Apr. 2015, To 30 Sep. 2015
          天然物有機化学
          集中, 広島大学, 大学院理学研究科
        • From 08 Apr. 2016, To 30 Sep. 2016
          天然物有機化学
          集中, 広島大学, 大学院理学研究科
        • From 01 Dec. 2016, To 31 Mar. 2017
          天然有機化合物と創薬R&D
          期間内2回, 筑波大学, 生命環境科学研究科
        • From 10 Apr. 2017, To 30 Sep. 2017
          天然物有機化学
          集中, 広島大学, 大学院理学研究科
        • From 09 Apr. 2018, To 30 Sep. 2018
          天然物有機化学
          集中, 広島大学, 大学院理学研究科
        • From 08 Apr. 2019, To 30 Sep. 2019
          天然物有機化学
          集中, 広島大学, 大学院統合生命科学研究科
        list
          Last Updated :2025/04/29

          Administration

          School management (title, position)

          • From 01 Apr. 2017, To 31 Mar. 2019
            環境管理専門委員会有機廃液情報管理小委員会　委員
          • From 01 Apr. 2015, To 31 Mar. 2021
            放射線障害予防小委員会　委員
          • From 01 Apr. 2019, To 31 Mar. 2023
            放射線障害予防小委員会　委員
          • From 01 Apr. 2019, To 31 Mar. 2021
            環境管理専門委員会有機廃液情報管理小委員会　委員

          Faculty management (title, position)

          • From 01 Apr. 2023, To 31 Mar. 2025
            男女共同参画推進委員会　委員
          • From 01 Apr. 2023, To 31 Mar. 2027
            図書委員会　委員
          • From 01 Oct. 2010
            放射線取扱主任者（農学研究科）
          • From 01 Oct. 2010
            エックス線作業主任者（農学研究科）
          • From 01 Apr. 2014, To 31 Mar. 2016
            広報委員会　委員
          • From 01 Apr. 2014, To 31 Mar. 2016
            研究活動推進委員会　委員
          • From 01 Apr. 2015, To 31 Mar. 2027
            動物実験委員会　委員
          • From 01 Apr. 2016, To 31 Mar. 2018
            環境・安全・衛生委員会　委員
          • From 01 Apr. 2015
            放射線障害防止委員会　委員
          • From 01 Apr. 2018, To 31 Mar. 2020
            広報委員会　委員
          list
            Last Updated :2025/04/29

            Academic, Social Contribution

            Committee Memberships

            • From Apr. 2019, To Present
              参与, 日本農芸化学会 関西支部
            • From Nov. 2022, To Present
              代議員, 日本認知症学会
            • From Jun. 2020, To May 2022
              代議員, 日本農芸化学会
            • From Oct. 2009, To Present
              天然物化学談話会世話人（2022.8~副代表）

            Academic Contribution

            • International Journal of Molecular Sciences (Guest Editor)
              Peer review
              From 2022, To Present
            • Frontiers in Molecular Neuroscience (Editorial Board)
              Peer review
              From 2020, To Present
            • PLoS One (Editorial Board)
              Peer review
              From 2019, To Present

            ページ上部へ戻る