Basic Information

Faculty

• 農学部

Email Address

• Email Address

  murakami.kazuma.4vkyoto-u.ac.jp

Professional Memberships

• 日本神経化学会
• 日本生化学会
• 日本ケミカルバイオロジー学会
• Society for Neuroscience
• American Chemical Society
• 日本認知症学会
• 日本ペプチド学会
• 日本農芸化学会
• 日本核酸医薬学会
• The Japan Society of Nucleic Acids Chemistry

Academic Degree

• 修士（農学）(京都大学)
• 博士（農学）(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院農学研究科博士後期課程食品生物科学専攻, 修了
• 京都大学, 大学院農学研究科修士課程食品生物科学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 京都大学, 農学部生物機能科学科, 卒業

High School

• High School

  清風高等学校

Research History

• From Apr. 2023, To Present

  学術変革領域研究（B）, 領域代表
• From Oct. 2022, To Nov. 2022

  カリフォルニア大学ロサンゼルス校, 客員准教授
• From 2013, To Present

  京都大学大学農学研究科准教授
• From 2009, To 2013

  京都大学農学研究科助教
• From 2007, To 2009

  日本学術振興会特別研究員SPD
• From 2004, To 2007

  日本学術振興会特別研究員DC1

Profile

• Profile

  『ケミカルバイオロジーを食品科学研究に導入することで健康長寿社会の実現に貢献したい』という目標を掲げています．これまでアミロイド蛋白質の凝集に関する生化学・有機化学研究から出発し, 神経変性疾患の検出・診断を目的とした核酸医薬，予防・治療を目的とした機能性食品分子の開発へと展開しました．その過程でアミロイド凝集体の新概念である学術変革領域「メタアグリゲート」の創成につながっています（学変B領域HP：https://www.metaaggregate.kais.kyoto-u.ac.jp/）．現在は以下の研究テーマに取り組んでいます．

  
  

  1. アミロイド凝集は生体中でどのように始まるのか？
  2. アミロイド凝集を阻害する機能性食品分子や腸内細菌産生物質はどれか？どのように？
  3. DNA/RNAアプタマーを用いて中枢疾患の早期診断と治療をどのように解決するか？
  4. スーパーカルコゲノイドはレドックス制御するか？酸化ストレス疾患の予防できるか？

  
  

  kaken DB: https://nrid.nii.ac.jp/ja/nrid/1000080571281/

Language of Instruction

• Japanese
• English

ID,URL

• ORCID ID

  0000-0003-3152-1784

• J-Global ID

  200901016636621112

• Researcher ID

  GQA-7062-2022

• Researcher number

  80571281

• External link

  https://www.metaaggregate.kais.kyoto-u.ac.jp/

Website(s) (URL(s))

• http://www.orgchem.kais.kyoto-u.ac.jp/
• https://www.metaaggregate.kais.kyoto-u.ac.jp/
• https://scholar.google.co.jp/citations?hl=ja&user=uJDRjosAAAAJ

researchmap URL

• https://researchmap.jp/read0134623

Research

Research Topics, Overview of the research

• Research Topics

  1. How does amyloid aggregation begin in living organisms?
  2. Which functional food molecules or gut microbiota-derived metabolites inhibit amyloid aggregation, and how?
  3. How can DNA/RNA aptamers contribute to the early diagnosis and treatment of central nervous system diseases?
  4. Do superchalcogenides regulate redox processes and thereby prevent oxidative stress-related diseases?

• Overview of the research

  Since neurodegenerative disorders such as Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis still lack curative therapies, this research focuses on elucidating the molecular mechanisms of amyloid aggregation and strategies to inhibit it from the following three perspectives. (1) Investigating RNA binding proteins and RNA structures, we will use bio-NMR spectroscopy to analyze the structure and formation mechanism of MetaAggregates. (2) We will clarify at the atomic level the effects of functional food molecules, gut microbiota-derived metabolites, and superchalcogenides aiming to develop personalized anti-dementia drugs through synergy optimization. (3) We will develop fluorescence-based diagnostic systems using nucleic acid aptamers and brain delivery technologies to propose novel approaches for early diagnosis and treatment of central nervous system diseases.

Research Interests

• functional food molecules
• Nucleic acid aptamer
• Chemical Biology
• MetaAggregates
• Superchalcogenide
• Amyloidogenic protein

Research Areas

• Environmental science/Agricultural science, Environmental agriculture, Food metabolism
• Life sciences, Biomedical engineering
• Life sciences, Bioorganic chemistry
• Nanotechnology/Materials, Molecular biochemistry

Papers

• Development of an RNA Aptamer as a Therapeutic Agent for Synucleinopathies

  Kazuma Murakami; Thi Hong Van Nguyen; Leo Tsuda; Esha Chawla; Yiran Chen; Chioko Nagao; Kenji Mizuguchi; Hidehito Tochio; Gal Bitan

  bioRxiv, 24 Aug. 2025, Lead author, Corresponding author

  
• Proteomic and in silico dissection of MetaAggregates in amyotrophic lateral sclerosis brains

  Kazuma Murakami; Thi Hong Van Nguyen; Nobuko Fujita; Chioko Nagao; Kenji Mizuguchi; Takumi Nishiuchi; Yasuhiro Sakashita; Moeko Noguchi-Shinohara; Kenjiro Ono

  bioRxiv, 11 Jul. 2025, Lead author, Corresponding author

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• Lysine-Targeting Inhibitors of Amyloidogenic Protein Aggregation: A Promise for Neurodegenerative Proteinopathies

  Kazuma Murakami; Thi Hong Van Nguyen; Chioko Nagao; Kenji Mizuguchi; Gal Bitan

  JACS Au, 25 Aug. 2025, Lead author, Corresponding author

  
• Neurotoxic Implications of Human Coronaviruses in Neurodegenerative Diseases: A Perspective from Amyloid Aggregation

  Thi Hong Van Nguyen; Francois Ferron; Kazuma Murakami

  ACS Chemical Biology, 16 May 2025, Last author, Corresponding author

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• Detection of Dietary Chalcone and Flavonoid Metabolites in Mice Using UPLC–MS/MS and Their Modulatory Effects on Amyloid β Aggregation

  Kota Taniwa; Kazuma Murakami; Yoshiki Sakaguchi; Naotaka Izuo; Mizuho Hanaki; Nobuaki Sampa; Toshiaki Kume; Takahiko Shimizu; Kazuhiro Irie

  Journal of Agricultural and Food Chemistry, 13 Sep. 2023, Peer-reviewed, Corresponding author

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• 神経疾患に対する核酸医薬：アプタマー医薬

  村上一馬

  脳神経内科, Jun. 2023, Invited, Lead author, Last author, Corresponding author

  
• 腸内細菌生産天然物による創薬研究の新展開

  村上一馬

  アグリバイオ, May 2023, Invited, Lead author, Last author, Corresponding author

  
• Lysine-targeting inhibition of amyloid β oligomerization by a green perilla-derived metastable chalcone in vitro and in vivo

  Kazuma Murakami; Yoshiki Sakaguchi; Kota Taniwa; Naotaka Izuo; Mizuho Hanaki; Taiji Kawase; Kenji Hirose; Takahiko Shimizu; Kazuhiro Irie

  RSC Chemical Biology, Oct. 2022, Peer-reviewed, Lead author, Corresponding author

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• Interactions of amyloid coaggregates with biomolecules and its relevance to neurodegeneration

  Kazuma Murakami; Kenjiro Ono

  The FASEB Journal, Sep. 2022, Peer-reviewed, Lead author, Corresponding author

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• Activity-differential search for amyloid-β aggregation inhibitors using LC-MS combined with principal component analysis

  Mizuho Hanaki; Kazuma Murakami; Hiroki Gunji; Kazuhiro Irie

  Bioorganic & Medicinal Chemistry Letters, Feb. 2022, Lead author, Corresponding author

  
• Synthetic Biology-Based Discovery of Diterpenoid Pyrones from the Genome of Eupenicillium shearii

  Yohei Morishita; Kento Tsukada; Kazuma Murakami; Kazuhiro Irie; Teigo Asai

  Journal of Natural Products, 20 Jan. 2022

  
• Aptamers targeting amyloidogenic proteins and their emerging role in neurodegenerative diseases

  Kazuma Murakami; Naotaka Izuo; Gal Bitan

  Journal of Biological Chemistry, Jan. 2022, Lead author, Corresponding author

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• Searching for Natural Products That Delay Nucleation Phase and Promote Elongation Phase of Amyloid β42 toward Alzheimer’s Disease Therapeutics

  Kazuma Murakami; Shiori Horii; Mizuho Hanaki; Kazuhiro Irie

  ACS Chemical Neuroscience, 31 Aug. 2021, Lead author, Corresponding author

  
• Development of a Novel Alzheimer's Disease Model Based on the Theory of the Toxic-conformer of Amyloid β

  Naotaka Izuo; Takahiko Shimizu; Kazuma Murakami; Kazuhiro Irie

  YAKUGAKU ZASSHI, 01 Jun. 2021

  
• Nucleic Acid Aptamer That Recognize Amyloid Protein: First RNA Aptamer Against Aβ42 Oligomer

  村上一馬; 入江一浩

  化学と生物, May 2021, Peer-reviewed, Invited, Lead author, Corresponding author

  
• Synthetic and Biophysical Studies on the Toxic Conformer in Amyloid β with the E22Δ Mutation in Alzheimer Pathology.

  Kazuma Murakami; Tomomi Yamaguchi; Naotaka Izuo; Toshiaki Kume; Hideyuki Hara; Kazuhiro Irie

  ACS Chemical Neuroscience, 07 Oct. 2020, Lead author, Corresponding author

  
• Detection of Amyloid β Oligomers with RNA Aptamers in AppNL-G-F/NL-G-F Mice: A Model of Arctic Alzheimer's Disease.

  Yayoi Obata; Kazuma Murakami; Taiji Kawase; Kenji Hirose; Naotaka Izuo; Takahiko Shimizu; Kazuhiro Irie

  ACS Omega, 01 Sep. 2020, Corresponding author

  
• Synthetic and biochemical studies on the effect of persulfidation on disulfide dimer models of amyloid b42 at position 35 in Alzheimer's etiology

  Kazuma Murakami; a; Haruka Kato; Mizuho Hanaki; a; Yoko Monobe; Ken-ichi Akagi; Taiji Kawase; c; Kenji Hirosec; Kazuhiro Irie

  RSC Adv., May 2020, Peer-reviewed, Corresponding author

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• Synthetic biology based construction of biological activity-related library of fungal decalin-containing diterpenoid pyrones.

  Kento Tsukada; Shono Shinki; Akiho Kaneko; Kazuma Murakami; Kazuhiro Irie; Masatoshi Murai; Hideto Miyoshi; Shingo Dan; Kumi Kawaji; Hironori Hayashi; Eiichi N Kodama; Aki Hori; Emil Salim; Takayuki Kuraishi; Naoya Hirata; Yasunari Kanda; Teigo Asai

  Nature Communications, 14 Apr. 2020, Peer-reviewed

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• An RNA aptamer with potent affinity for a toxic dimer of amyloid β42 has potential utility for histochemical studies of Alzheimer's disease.

  Kazuma Murakami; Yayoi Obata; Asa Sekikawa; Haruka Ueda; Naotaka Izuo; Tatsuya Awano; Keiji Takabe; Takahiko Shimizu; Kazuhiro Irie

  Journal of Biological Chemistry, 10 Apr. 2020, Peer-reviewed, Lead author, Corresponding author

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• Synthesis and physicochemical properties of 20-mer peptide nucleic acid conjugates with testosterone 17β-carboxylic acid

  Ryotaro Yagita a; Kazuma Murakami a; Hisafumi Ikeda b; Kazuhiro Irie a

  Tetrahedron Letters, Apr. 2020, Peer-reviewed, Corresponding author

  
• Insulin deficiency promotes formation of toxic amyloid-β42 conformer co-aggregating with hyper-phosphorylated tau oligomer in an Alzheimer's disease model.

  Tomohiro Imamura; Yuki T Yanagihara; Yasumasa Ohyagi; Norimichi Nakamura; Kyoko M Iinuma; Ryo Yamasaki; Hirohide Asai; Masahiro Maeda; Kazuma Murakami; Kazuhiro Irie; Jun-Ichi Kira

  Neurobiology of disease, Apr. 2020, Peer-reviewed

  
• Evaluation of Toxic Amyloid 42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator.

  Kazuma Murakami; Mayuko Yoshimura; Shota Nakagawa; Toshiaki Kume; Takayuki Kondo; Haruhisa Inoue; Kazuhiro Irie

  International journal of molecular sciences, 11 Feb. 2020, Peer-reviewed, Lead author, Corresponding author

  
• An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease.

  Naotaka Izuo; Kazuma Murakami; Yoshitaka Fujihara; Masahiro Maeda; Takashi Saito; Takaomi C Saido; Kazuhiro Irie; Takahiko Shimizu

  Biochemical and biophysical research communications, 30 Jul. 2019, Peer-reviewed

  
• 

  Three Structural Features of Functional Food Components and Herbal Medicine with Amyloid β42 Anti-Aggregation Properties.

  Kazuma Murakami; Kazuhiro Irie

  Molecules, 05 Jun. 2019, Peer-reviewed, Invited, Lead author, Corresponding author

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• Synthesis and biochemical characterization of quasi-stable trimer models of full-length amyloid β40 with a toxic conformation.

  Yumi Irie; Mizuho Hanaki; Kazuma Murakami; Tsuneo Imamoto; Takumi Furuta; Takeo Kawabata; Taiji Kawase; Kenji Hirose; Yoko Monobe; Ken-Ichi Akagi; Ryo C Yanagita; Kazuhiro Irie

  Chemical Communications, 20 Dec. 2018, Peer-reviewed

  
• Amyloid β toxic conformer has dynamic localization in the human inferior parietal cortex in absence of amyloid plaques.

  Yusuke Kageyama; Atsushi Saito; Olga Pletnikova; Gay L Rudow; Yumi Irie; Yang An; Kazuma Murakami; Kazuhiro Irie; Susan M Resnick; David R Fowler; Lee J Martin; Juan C Troncoso

  Scientific Reports, 15 Nov. 2018, Peer-reviewed

  
• Role of the carboxy groups of triterpenoids in their inhibition of the nucleation of amyloid β42 required for forming toxic oligomers.

  Kazuma Murakami; Takuya Yoshioka; Shiori Horii; Mizuho Hanaki; Satohiro Midorikawa; Shinji Taniwaki; Hiroki Gunji; Ken-Ichi Akagi; Taiji Kawase; Kenji Hirose; Kazuhiro Irie

  Chemical communications (Cambridge, England), 14 Jun. 2018, Peer-reviewed, Lead author

  
• Mechanistic analyses of the suppression of amyloid β42 aggregation by apomorphine.

  Mizuho Hanaki; Kazuma Murakami; Sumie Katayama; Ken-Ichi Akagi; Kazuhiro Irie

  Bioorganic & medicinal chemistry, 01 May 2018, Peer-reviewed

  
• アミロイドβ「毒性コンホマー」を標的にしたアルツハイマー病の治療・診断法の開発

  泉尾直孝; 清水孝彦; 村上一馬; 入江一浩

  医薬品医療機器レギュラトリーサイエンス, 2018

  
• A Toxic Conformer of Aβ42 with a Turn at 22-23 is a Novel Therapeutic Target for Alzheimer's Disease.

  Naotaka Izuo; Chihiro Kasahara; Kazuma Murakami; Toshiaki Kume; Masahiro Maeda; Kazuhiro Irie; Koutaro Yokote; Takahiko Shimizu

  Scientific reports, 18 Sep. 2017, Peer-reviewed

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• INHIBITORY ACTIVITY OF HISPIDIN DERIVATIVES ISOLATED FROM INONOTUS OBLIQUUS ON AMYLOID beta AGGREGATION

  Yukine Aihara; Ayumi Kawaguchi; Mizuho Hanaki; Kazuma Murakami; Kazuhiro Irie; Hideyuki Shigemori

  HETEROCYCLES, Jul. 2017, Peer-reviewed

  
• Synthesized Aβ42 Caused Intracellular Oxidative Damage, Leading to Cell Death, via Lysosome Rupture.

  Yuki Oku; Kazuma Murakami; Kazuhiro Irie; Jun Hoseki; Yasuyoshi Sakai

  Cell Structure and Function, 23 May 2017, Peer-reviewed

  
• Synthetic Models of Quasi-Stable Amyloid β40 Oligomers with Significant Neurotoxicity.

  Yumi Irie; Kazuma Murakami; Mizuho Hanaki; Yusuke Hanaki; Takashi Suzuki; Yoko Monobe; Tomoyo Takai; Ken-Ichi Akagi; Taiji Kawase; Kenji Hirose; Kazuhiro Irie

  ACS chemical neuroscience, 19 Apr. 2017, Peer-reviewed

  
• 食品・生薬成分によるアミロイドβ42の凝集抑制機構の系統的解析

  K. Murakami; K. Irie

  日本認知症学会誌, 2017, Invited

  
• Inhibitory Activities of Antioxidant Flavonoids from Tamarix gallica on Amyloid Aggregation Related to Alzheimer's and Type 2 Diabetes Diseases.

  Asma Ben Hmidene; Mizuho Hanaki; Kazuma Murakami; Kazuhiro Irie; Hiroko Isoda; Hideyuki Shigemori

  Biological & Pharmaceutical Bulletin, 2017, Peer-reviewed

  
• STRUCTURE-ACTIVITY RELATIONSHIP OF PHENYLETHANOID GLYCOSIDES ON THE INHIBITION OF AMYLOID beta AGGREGATION

  Eri Kidachi; Manami Kurisu; Yusaku Miyamae; Mizuho Hanaki; Kazuma Murakami; Kazuhiro Irie; Hideyuki Shigemori

  HETEROCYCLES, Nov. 2016, Peer-reviewed

  
• Semisynthesis and Structure-Activity Studies of Uncarinic Acid C Isolated from Uncaria rhynchophylla as a Specific Inhibitor of the Nucleation Phase in Amyloid β42 Aggregation.

  Takuya Yoshioka; Kazuma Murakami; Kyohei Ido; Mizuho Hanaki; Kanoko Yamaguchi; Satohiro Midorikawa; Shinji Taniwaki; Hiroki Gunji; Kazuhiro Irie

  Journal of Natural Products, 28 Oct. 2016, Peer-reviewed

  
• Monoclonal antibody with conformational specificity for a toxic conformer of amyloid β42 and its application toward the Alzheimer's disease diagnosis.

  Kazuma Murakami; Maki Tokuda; Takashi Suzuki; Yumi Irie; Mizuho Hanaki; Naotaka Izuo; Yoko Monobe; Ken-Ichi Akagi; Ryotaro Ishii; Harutsugu Tatebe; Takahiko Tokuda; Masahiro Maeda; Toshiaki Kume; Takahiko Shimizu; Kazuhiro Irie

  Scientific reports, 04 Jul. 2016, Peer-reviewed, Lead author

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• Structural insights into mechanisms for inhibiting amyloid β42 aggregation by non-catechol-type flavonoids.

  Mizuho Hanaki; Kazuma Murakami; Ken-ichi Akagi; Kazuhiro Irie

  Bioorganic & medicinal chemistry, 15 Jan. 2016, Peer-reviewed

  
• Synthesis and characterization of the amyloid β40 dimer model with a linker at position 30 adjacent to the intermolecular β-sheet region.

  Kazuma Murakami; Takashi Suzuki; Mizuho Hanaki; Yoko Monobe; Ken-Ichi Akagi; Kazuhiro Irie

  Biochemical and biophysical research communications, 23 Oct. 2015, Peer-reviewed, Lead author

  
• Pathophysiological activities of the "toxic conformer" and the "non-toxic conformer" of amyloid beta-induced neurotoxicity

  Izuo Naotaka; Kume Toshiaki; Murakami Kazuma; Irie Kazuhiro; Izumi Yasuhiko; Akaike Akinori; Yokote Koutaro; Shimizu Takahiko

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Jul. 2015, Peer-reviewed

  
• アルツハイマー病様神経毒性におけるアミロイドβコンホマーの役割

  泉尾直孝; 村上一馬; 久米利明; 前田雅弘; 入江一浩; 清水孝彦

  基礎老化研究, 2015, Invited

  
• Potential Role of Vitamin C in the Prevention of Alzheimer's Disease

  Kazuma Murakami; Kazuhiro Irie; Takahiko Shimizu

  Diet and Nutrition in Dementia and Cognitive Decline, 18 Nov. 2014, Peer-reviewed

  
• Induction of Oxidative stress by the "toxic conformer" is crucial for A beta 42

  Izuo Naotaka; Kume Toshiaki; Murakami Kazuma; Sato Mizuho; Irie Kazuhiro; Izumi Yasuhiko; Akaike Akinori; Yokote Koutaro; Shimizu Takahiko

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, Peer-reviewed

  
• Conformation-specific antibodies to target amyloid β oligomers and their application to immunotherapy for Alzheimer's disease.

  Kazuma Murakami

  Bioscience, biotechnology, and biochemistry, 2014, Peer-reviewed, Lead author, Last author, Corresponding author

  
• Non-toxic conformer of amyloid β may suppress amyloid β-induced toxicity in rat primary neurons: implications for a novel therapeutic strategy for Alzheimer's disease.

  Naotaka Izuo; Kazuma Murakami; Mizuho Sato; Mami Iwasaki; Yasuhiko Izumi; Takahiko Shimizu; Akinori Akaike; Kazuhiro Irie; Toshiaki Kume

  Biochemical and biophysical research communications, 16 Aug. 2013, Peer-reviewed

  
• Site-specific inhibitory mechanism for amyloid β42 aggregation by catechol-type flavonoids targeting the Lys residues.

  Mizuho Sato; Kazuma Murakami; Mayumi Uno; Yu Nakagawa; Sumie Katayama; Ken-ichi Akagi; Yuichi Masuda; Kiyonori Takegoshi; Kazuhiro Irie

  The Journal of biological chemistry, 09 Aug. 2013, Peer-reviewed

  
• Structure-activity studies on the side chain of a simplified analog of aplysiatoxin (aplog-1) with anti-proliferative activity.

  Hiroaki Kamachi; Keisuke Tanaka; Ryo C Yanagita; Akira Murakami; Kazuma Murakami; Harukuni Tokuda; Nobutaka Suzuki; Yu Nakagawa; Kazuhiro Irie

  Bioorganic & Medicinal Chemistry, 15 May 2013, Peer-reviewed

  
• Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness.

  Takayuki Kondo; Masashi Asai; Kayoko Tsukita; Yumiko Kutoku; Yutaka Ohsawa; Yoshihide Sunada; Keiko Imamura; Naohiro Egawa; Naoki Yahata; Keisuke Okita; Kazutoshi Takahashi; Isao Asaka; Takashi Aoi; Akira Watanabe; Kaori Watanabe; Chie Kadoya; Rie Nakano; Dai Watanabe; Kei Maruyama; Osamu Hori; Satoshi Hibino; Tominari Choshi; Tatsutoshi Nakahata; Hiroyuki Hioki; Takeshi Kaneko; Motoko Naitoh; Katsuhiro Yoshikawa; Satoko Yamawaki; Shigehiko Suzuki; Ryuji Hata; Shu-Ichi Ueno; Tsuneyoshi Seki; Kazuhiro Kobayashi; Tatsushi Toda; Kazuma Murakami; Kazuhiro Irie; William L Klein; Hiroshi Mori; Takashi Asada; Ryosuke Takahashi; Nobuhisa Iwata; Shinya Yamanaka; Haruhisa Inoue

  Cell stem cell, 04 Apr. 2013, Peer-reviewed

  
• Development of a platinum complex as an anti-amyloid agent for the therapy of Alzheimer's disease.

  Vijaya B Kenche; Lin W Hung; Keyla Perez; Irene Volitakes; Guiseppe Ciccotosto; Jeffrey Kwok; Nicole Critch; Nikki Sherratt; Mikhalina Cortes; Varsha Lal; Colin L Masters; Kazuma Murakami; Roberto Cappai; Paul A Adlard; Kevin J Barnham

  Angewandte Chemie (International ed. in English), 18 Mar. 2013, Peer-reviewed

  
• Structure-activity relationship for (+)-taxifolin isolated from silymarin as an inhibitor of amyloid β aggregation.

  Mizuho Sato; Kazuma Murakami; Mayumi Uno; Haruko Ikubo; Yu Nakagawa; Sumie Katayama; Ken-Ichi Akagi; Kazuhiro Irie

  Bioscience, Biotechnology, and Biochemistry, 2013, Peer-reviewed

  
• Inhibition of amyloid β aggregation by acteoside, a phenylethanoid glycoside.

  Manami Kurisu; Yusaku Miyamae; Kazuma Murakami; Junkyu Han; Hiroko Isoda; Kazuhiro Irie; Hideyuki Shigemori

  Bioscience, Biotechnology, and Biochemistry, 2013, Peer-reviewed

  
• Intracellular accumulation of toxic turn amyloid-β is associated with endoplasmic reticulum stress in Alzheimer's disease.

  Naoko Soejima; Yasumasa Ohyagi; Norimichi Nakamura; Eri Himeno; Kyoko M Iinuma; Nobutaka Sakae; Ryo Yamasaki; Takeshi Tabira; Kazuma Murakami; Kazuhiro Irie; Noriaki Kinoshita; Frank M LaFerla; Yutaka Kiyohara; Toru Iwaki; Jun-ichi Kira

  Current Alzheimer research, Jan. 2013, Peer-reviewed

  
• Early accumulation of intracellular fibrillar oligomers and late congophilic amyloid angiopathy in mice expressing the Osaka intra-A beta APP mutation

  L. Kulic; J. McAfoose; T. Welt; C. Tackenberg; C. Spaeni; F. Wirth; V. Finder; U. Konietzko; M. Giese; A. Eckert; K. Noriaki; T. Shimizu; K. Murakami; K. Irie; S. Rasool; C. Glabe; C. Hock; R. M. Nitsch

  TRANSLATIONAL PSYCHIATRY, Nov. 2012, Peer-reviewed

  
• Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein.

  Yusaku Miyamae; Manami Kurisu; Kazuma Murakami; Junkyu Han; Hiroko Isoda; Kazuhiro Irie; Hideyuki Shigemori

  Bioorganic & medicinal chemistry, 01 Oct. 2012, Peer-reviewed

  
• Caffeoylquinic acids inhibit amyloid β fibril formation and cellular toxicity.

  Miyamae, Y; Kurisu, M; Murakami, K; Han, J; Isoda, H; Irie, K; Shigemori, H

  Bioorg. Med. Chem. 19 (1), 5844-5849 (2012)., Oct. 2012, Peer-reviewed

  
• Toxicity in Rat Primary Neurons through the Cellular Oxidative Stress Induced by the Turn Formation at Positions 22 and 23 of A beta 42

  Naotaka Izuo; Toshiaki Kume; Mizuho Sato; Kazuma Murakami; Kazuhiro Irie; Yasuhiko Izumi; Akinori Akaike

  ACS chemical neuroscience, Sep. 2012, Peer-reviewed

  
• SOD1の減少はアルツハイマー病様病態を早期に発症させる

  清水 孝彦; 村上 一馬; 村田 央; 野田 義博; 初田 裕幸; 村山 繁雄; 入江 一浩; 白澤 卓二

  日本抗加齢医学会総会プログラム・抄録集, Jun. 2012

  
• Cytoplasmic superoxide radical: a possible contributing factor to intracellular Aβ oligomerization in Alzheimer disease.

  Kazuma Murakami; Takahiko Shimizu

  Communicative & Integrative Biology, 01 May 2012, Peer-reviewed, Lead author, Corresponding author

  
• Geranyl modification on the tryptophan residue of ComXRO-E-2 pheromone by a cell-free system.

  Fumitada Tsuji; Ayako Ishihara; Keiko Kurata; Aya Nakagawa; Masahiro Okada; Shigeyuki Kitamura; Kyoko Kanamaru; Yuichi Masuda; Kazuma Murakami; Kazuhiro Irie; Youji Sakagami

  FEBS Letters, 20 Jan. 2012, Peer-reviewed

  
• Lack of the consensus sequence necessary for tryptophan prenylation in the ComX pheromone precursor.

  Fumitada Tsuji; Ayako Ishihara; Aya Nakagawa; Masahiro Okada; Shigeyuki Kitamura; Kyoko Kanamaru; Yuichi Masuda; Kazuma Murakami; Kazuhiro Irie; Youji Sakagami

  Bioscience, Biotechnology, and Biochemistry, 2012, Peer-reviewed

  
• Crucial role of the turn at positions 22-23 in neurotoxicity of amyloid beta

  Izuo Naotaka; Kume Toshiaki; Sato Mizuho; Murakami Kazuma; Irie Kazuhiro; Izumi Yasuhiko; Akaike Akinori

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2012, Peer-reviewed

  
• Aβの毒性ターン構造を認識する抗体

  村上一馬; 入江一浩

  神経内科, 2012, Invited, Lead author

  
• アミロイドβの「毒性コンホマー」形成とGlu22位における遺伝性変異

  村上一馬; 佐藤瑞穂; 鈴木啓之; 泉尾直孝; 久米利明; 赤池昭紀; 永田 徹; 西崎知之; 富山貴美; 森 啓; 入江一浩

  Dementia Japan,, 2012, Invited, Lead author

  
• Identification and biological activities of bryostatins from Japanese bryozoan.

  Sayo Ueno; Ryo C Yanagita; Kazuma Murakami; Akira Murakami; Harukuni Tokuda; Nobutaka Suzuki; Takeshi Fujiwara; Kazuhiro Irie

  Bioscience, Biotechnology, and Biochemistry, 2012, Peer-reviewed

  
• ComX pheromone precursor contains no consensus sequence necessary for tryptophan prenylation.

  Tsuji, F; Ishihara, A; Kurata, K; Nakagawa, A; Okada, M; Kitamura, S; Kanamaru, K; Masuda, Y; Murakami, K; Irie, K; Sakagami, Y

  Biosci. Biotechnol. Biochem. 76 (8), 1492-1496 (2012)., 2012, Peer-reviewed

  
• Stimulation of the amyloidogenic pathway by cytoplasmic superoxide radicals in an Alzheimer's disease mouse model.

  Kazuma Murakami; Nakaba Murata; Yoshihiro Noda; Kazuhiro Irie; Takuji Shirasawa; Takahiko Shimizu

  Bioscience, biotechnology, and biochemistry, 2012, Peer-reviewed, Lead author

  
• Preparation of stable amyloid β-protein oligomers of defined assembly order.

  Clark Rosensweig; Kenjiro Ono; Kazuma Murakami; Devin K Lowenstein; Gal Bitan; David B Teplow

  Methods in molecular biology (Clifton, N.J.), 2012, Peer-reviewed

  
• SOD1 (copper/zinc superoxide dismutase) deficiency drives amyloid β protein oligomerization and memory loss in mouse model of Alzheimer disease.

  Kazuma Murakami; Nakaba Murata; Yoshihiro Noda; Shoichi Tahara; Takao Kaneko; Noriaki Kinoshita; Hiroyuki Hatsuta; Shigeo Murayama; Kevin J Barnham; Kazuhiro Irie; Takuji Shirasawa; Takahiko Shimizu

  The Journal of Biological Chemistry, 30 Dec. 2011, Peer-reviewed, Lead author

  
• アルツハイマー病の分子治療戦略 新しい視点を求めて アミロイドβの毒性ターン構造を認識する抗体の開発

  入江 一浩; 村上 一馬; 増田 裕一; 村田 央; 野田 義博; 初田 裕幸; 村山 繁雄; 清水 孝彦; 堀越 優子; 木下 憲明; 白澤 卓二

  臨床神経学, Nov. 2011

  
• [Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23].

  Kazuhiro Irie; Kazuma Murakami; Yuichi Masuda; Nakaba Murata; Yoshihiro Noda; Hiroyuki Hatsuta; Shigeo Murayama; Takahiko Shimizu; Yuko Horikoshi; Noriaki Kinoshita; Takuji Shirasawa

  Rinsho Shinkeigaku = Clinical neurology, Nov. 2011, Peer-reviewed

  
• Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice

  Kazuma Murakami; Shin-ichi Yokoyama; Nakaba Murata; Yusuke Ozawa; Kazuhiro Irie; Takuji Shirasawa; Takahiko Shimizu

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2011, Peer-reviewed

  
• Formation of the 42-mer Amyloid β Radical and the Therapeutic Role of Superoxide Dismutase in Alzheimer's Disease.

  Kazuma Murakami; Takahiko Shimizu; Kazuhiro Irie

  Journal of Amino Acids, 2011, Peer-reviewed, Lead author

  
• Vitamin C restores behavioral deficits and amyloid-β oligomerization without affecting plaque formation in a mouse model of Alzheimer's disease.

  Kazuma Murakami; Nakaba Murata; Yusuke Ozawa; Noriaki Kinoshita; Kazuhiro Irie; Takuji Shirasawa; Takahiko Shimizu

  Journal of Alzheimer's disease : JAD, 2011, Peer-reviewed, Lead author

  
• E22Δ Mutation in Amyloid β-Protein Promotes β-Sheet Transformation, Radical Production, and Synaptotoxicity, But Not Neurotoxicity.

  Takayuki Suzuki; Kazuma Murakami; Naotaka Izuo; Toshiaki Kume; Akinori Akaike; Tetsu Nagata; Tomoyuki Nishizaki; Takami Tomiyama; Hiroshi Takuma; Hiroshi Mori; Kazuhiro Irie

  International journal of Alzheimer's disease, 19 Dec. 2010, Peer-reviewed

  
• Monoclonal antibody against the turn of the 42-residue amyloid β-protein at positions 22 and 23.

  Kazuma Murakami; Yuko Horikoshi-Sakuraba; Nakaba Murata; Yoshihiro Noda; Yuichi Masuda; Noriaki Kinoshita; Hiroyuki Hatsuta; Shigeo Murayama; Takuji Shirasawa; Takahiko Shimizu; Kazuhiro Irie

  ACS chemical neuroscience, 17 Nov. 2010, Peer-reviewed, Lead author

  
• The turn formation at positions 22 and 23 in the 42-mer amyloid beta peptide: the emerging role in the pathogenesis of Alzheimer's disease.

  Kazuma Murakami; Yuichi Masuda; Takuji Shirasawa; Takahiko Shimizu; Kazuhiro Irie

  Geriatrics & Gerontology International, Jul. 2010, Peer-reviewed, Lead author

  
• Silymarin attenuated the amyloid β plaque burden and improved behavioral abnormalities in an Alzheimer's disease mouse model.

  Nakaba Murata; Kazuma Murakami; Yusuke Ozawa; Noriaki Kinoshita; Kazuhiro Irie; Takuji Shirasawa; Takahiko Shimizu

  Bioscience, Biotechnology, and Biochemistry, 2010, Peer-reviewed

  
• RNA aptamers generated against oligomeric Abeta40 recognize common amyloid aptatopes with low specificity but high sensitivity.

  Farid Rahimi; Kazuma Murakami; Jamie L Summers; Chi-Hong B Chen; Gal Bitan

  PloS one, 10 Nov. 2009, Peer-reviewed

  
• Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative.

  Kazuma Murakami; Jun Inagaki; Mitsuru Saito; Yasutaka Ikeda; Chizuru Tsuda; Yoshihiro Noda; Satoru Kawakami; Takuji Shirasawa; Takahiko Shimizu

  Biochemical and Biophysical Research Communications, 01 May 2009, Peer-reviewed, Lead author

  
• Isomerization and/or racemization at Asp23 of A beta 42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro

  Kazuma Murakami; Mayumi Uno; Yuichi Masuda; Takahiko Shimizu; Takuji Shirasawa; Kazuhiro Irie

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2008, Peer-reviewed, Lead author

  
• アミロイドβ (Aβ42) の毒性コンホメーションの提唱

  村上 一馬; 清水 孝彦; 白澤 卓二; 入江 一浩

  基礎老化研究, 2008, Peer-reviewed, Invited, Lead author, Corresponding author

  
• Distance measurement between Tyr10 and Met35 in amyloid beta by site-directed spin-labeling ESR spectroscopy: implications for the stronger neurotoxicity of Abeta42 than Abeta40.

  Kazuma Murakami; Hideyuki Hara; Yuichi Masuda; Hajime Ohigashi; Kazuhiro Irie

  ChemBioChem : a European journal of chemical biology, 17 Dec. 2007, Peer-reviewed, Lead author

  
• The toxic conformation of the 42-residue amyloid β peptide and its relevance to oxidative stress in Alzheimer's disease

  K. Irie; K. Murakami; Y. Masuda; A. Morimoto; H. Ohigashi; H. Hara; R. Ohashi; K. Takegoshi; H. Fukuda; M. Nagao; T. Shimizu; T. Shirasawa

  Mini-Reviews in Medicinal Chemistry, Oct. 2007, Peer-reviewed

  
• Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR.

  Yuichi Masuda; Kazuhiro Irie; Kazuma Murakami; Hajime Ohigashi; Ryutaro Ohashi; K Takegoshi; Takahiko Shimizu; Takuji Shirasawa

  Bioorganic & Medicinal Chemistry, 15 Dec. 2005, Peer-reviewed

  
• Formation and stabilization model of the 42-mer Abeta radical: implications for the long-lasting oxidative stress in Alzheimer's disease.

  Kazuma Murakami; Kazuhiro Irie; Hajime Ohigashi; Hideyuki Hara; Masaya Nagao; Takahiko Shimizu; Takuji Shirasawa

  Journal of the American Chemical Society, 02 Nov. 2005, Peer-reviewed, Lead author

  
• Structure of beta-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer's disease.

  Kazuhiro Irie; Kazuma Murakami; Yuichi Masuda; Akira Morimoto; Hajime Ohigashi; Ryutaro Ohashi; Kiyonori Takegoshi; Masaya Nagao; Takahiko Shimizu; Takuji Shirasawa

  Journal of Bioscience and Bioengineering, May 2005, Peer-reviewed

  
• Analysis of the secondary structure of beta-amyloid (Abeta42) fibrils by systematic proline replacement.

  Akira Morimoto; Kazuhiro Irie; Kazuma Murakami; Yuichi Masuda; Hajime Ohigashi; Masaya Nagao; Hiroyuki Fukuda; Takahiko Shimizu; Takuji Shirasawa

  Journal of Biological Chemistry, 10 Dec. 2004, Peer-reviewed

  
• Neurotoxicity and physicochemical properties of A beta mutant peptides from cerebral amyloid angiopathy - Implication for the pathogenesis of cerebral amyloid angiopathy and Alzheimer's disease

  K Murakami; K Irie; A Morimoto; H Ohigashi; M Shindo; M Nagao; T Shimizu; T Shirasawa

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2003, Peer-reviewed, Lead author

  
• Aggregation and neurotoxicity of mutant amyloid beta (A beta) peptides with proline replacement: importance of turn formation at positions 22 and 23.

  Akira Morimoto; Kazuhiro Irie; Kazuma Murakami; Hajime Ohigashi; Mayumi Shindo; Masaya Nagao; Takahiko Shimizu; Takuji Shirasawa

  Biochemical and Biophysical Research Communications, 12 Jul. 2002, Peer-reviewed

  
• Synthesis, aggregation, neurotoxicity, and secondary structure of various A beta 1-42 mutants of familial Alzheimer's disease at positions 21-23

  K Murakami; K Irie; A Morimoto; H Ohigashi; M Shindo; M Nagao; T Shimizu; T Shirasawa

  Biochemical and Biophysical Research Communications, May 2002, Peer-reviewed, Lead author

  

Misc.

• ○○ならではのハプニング

  村上一馬

  内藤記念科学振興財団 時報, Mar. 2025

  
• リアル学会での偶然から

  村上一馬

  内藤記念科学振興財団 時報, Sep. 2021, Invited

  
• 33. Functional analysis of new peptide hormones that control stomatal formation

  Hirabayashi Tomomi; Sugita Taiga; Hokoyama Mayumi; Kondo Tatsuhiko; Murakami Kazuma; Irie Kazuhiro; Kakimoto Tatsuo; Sakagami Youji

  植物化学調節学会研究発表記録集, 03 Oct. 2011

  
• アミロイドβのプロトフィブリルを認識するRNAアプタマー

  村上一馬

  第38回日本認知症学会学術集会（京王プラザホテル、東京）, Nov. 2020, Peer-reviewed

  
• アミロイドβの凝集を抑制する食品・生薬成分の作用機構

  入江一浩; 村上一馬

  2019年度日本農芸化学会大会（東京農大、東京）, Mar. 2019

  
• アミロイドβ42の毒性オリゴマーに対する核酸アプタマーの開発研究と脳組織染色への応用

  村上一馬

  2019年度日本農芸化学会大会（東京農大、東京）, Mar. 2019

  
• 生合成経路の再構築と再設計による糸状菌ジテルペノイドピロンライブラリーの構築と生物活性評価

  塚田健人; 塚田健人; 金子秋穂; 新木翔之; 河治久実; 児玉栄一; 倉石貴透; 村上一馬; 入江一浩; 平田尚也; 諫田泰成; 浅井禎吾

  メディシナルケミストリーシンポジウム講演要旨集, 01 Nov. 2018

  
• 生合成経路の再構築と再設計による糸状菌ジテルペノイドピロンライブラリーの構築と生物活性評価

  塚田健人; 塚田健人; 金子秋穂; 新木翔之; 河治久実; 児玉栄一; 倉石貴透; 村上一馬; 入江一浩; 平田尚也; 諫田泰成; 浅井禎吾

  メディシナルケミストリーシンポジウム講演要旨集, 01 Nov. 2018

  
• RNA aptamers targeting the toxic oligomers of Aβ42 and their application to immunohistochemistry

  K. Murakami

  The 45th International Syposium on Nucleic Acids Chemistry (Kyoto University Clock Tower Centennial Hall) (Kyoto, Japan), Nov. 2018

  
• 天然物によるアミロイドβの毒性オリゴマー形成阻害機構

  村上一馬

  第37回日本認知症学会学術集会（ロイトン札幌・札幌市教育文化会館、札幌市）, Oct. 2018

  
• 生薬チョウトウコウに含まれるアミロイドβオリゴマー形成阻害物質の同定と作用機構

  村上一馬

  第59回天然有機化合物討論会（わくわくホリデーホール、札幌市）, Sep. 2017, Peer-reviewed

  
• アミロイドβの毒性配座理論と抗体創製

  村上一馬; 入江一浩

  認知症研究を知る若手研究者の集まり2017（湯の宿木もれび、大津市）, Jul. 2017

  
• アミロイドβ42の35番目でジスルフィド架橋したダイマーの合成と活性評価

  村上一馬

  2017年度日本農芸化学会大会（京都女子大学、京都市）, Mar. 2017

  
• 天然ポリフェノールによるAβ42凝集阻害機構の解明とアルツハイマー病予防の可能性

  村上一馬; 入江一浩

  第35回日本認知症学会学術集会（東京国際フォーラム、東京都千代田区）, Dec. 2016, Invited

  
• アミロイドβの毒性コンホマーにきわめて特異的な抗体の開発とアルツハイマー病診断への応用

  村上一馬

  2016年度日本農芸化学会大会（札幌コンベンションセンター、札幌市）, Mar. 2016

  
• Characterization of the monoclonal antibody (24B3) highly recognizing the toxic turn of amyloid β42 and its application to diagnosis for Alzheimer’s disease

  K. Murakami

  The 8th Takeda Science Foundation Symposium on PharmaSciences “Biomolecule-based Medicinal Science: Featuring Mid-Size Drugs” (Takeda Pharmaceutical Company, Ltd.) (Suita, Japan), Jan. 2016

  
• 神経細胞内に蓄積したAβ42が細胞死を引き起こす機構

  奥 勇紀; 村上 一馬; 入江 一浩; 寶関 淳; 阪井 康能

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• Characterization of monoclonal antibodies against the toxic turn of amyloid β42 and their application to diagnosis for Alzheimer’s disease.

  K. Murakami

  2015 International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) (Hawaii, USA), Dec. 2015, Invited

  
• アミロイドβの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用

  村上一馬; 入江一浩

  第8回たんぱく質の異常凝集とその防御・修復機構に関する研究会（京都大学原子炉実験所、熊取町）, Nov. 2015

  
• アミロイドβの毒性コンホマーを極めて特異的に認識する抗体の開発とAD診断への応用

  村上一馬

  第34回日本認知症学会学術集会（リンクステーションホール青森）, Oct. 2015

  
• アミロイドβペプチドの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用

  K. Murakami; K. Irie

  第47回若手ペプチド夏の勉強会、信州塩尻・天然温泉アスティかたおか（塩尻市）, Aug. 2015, Invited

  
• 神経細胞内に蓄積したAβ42による細胞毒性の発現機構

  奥勇紀; 村上一馬; 入江一浩; 寶関淳; 阪井康能

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2015

  
• 青じそ由来化合物DDC のAβ誘発神経毒性に対する保護作用

  岩崎真実; 泉安彦; 村上一馬; 入江一浩; 赤池昭紀; 久米利明

  次世代を担う創薬・医療薬理シンポジウム2014, Aug. 2014

  
• Inhibitors for Aβ42 aggregation in a traditional herbal medicine Uncaria rhynchophylla

  K. Murakami

  Alzheimer’s Association International Conference (Bella Center A/S, Copenhagen, Denmark), Jul. 2014, Peer-reviewed

  
• Aβ42誘発神経毒性には「毒性コンホマー」による酸化ストレスの誘導が重要である

  泉尾直孝; 久米利明; 村上一馬; 佐藤瑞穂; 入江一浩; 泉安彦; 赤池昭紀; 横手幸太郎; 清水孝彦

  第87回日本薬理学会年会, Mar. 2014

  
• 伝統生薬チョウトウコウに含まれるアミロイドβ凝集抑制物質

  村上一馬

  2014年度日本農芸化学会大会（東京）, Mar. 2014

  
• 神経細胞内に蓄積したAβ42による細胞毒性の発症機構

  奥勇紀; 村上一馬; 入江一浩; 寳関淳; 阪井康能

  日本分子生物学会年会プログラム・要旨集(Web), 2014

  
• 食品由来カフェオイルキナ酸の神経細胞保護効果

  繁森英幸; 宮前友策; 栗栖真奈美; 村上一馬; 入江一浩; Han Junkyu; 礒田博子

  日本機能性食品医用学会, Dec. 2013, Peer-reviewed

  
• ポリフェノールによるアミロイドβ42の凝集抑制機構

  村上一馬

  第6回タンパク質の異常凝集とその防御・修復機構に関する研究会（京都大学原子炉実験所）, Nov. 2013

  
• アルツハイマー病患者iPS細胞由来神経系細胞におけるAβオリゴマーの細胞毒性

  中野 梨絵; 浅井 将; 近藤 孝之; 月田 香代子; 渡邊 かおり; 門谷 千恵; 村上 一馬; 入江 一浩; Klein William L; 森 啓; 丸山 啓; 朝田 隆; 城谷 圭朗; 井上 治久; 岩田 修永

  Dementia Japan, Oct. 2013

  
• Vitamin C and silymarin restores Aβ oligomerization and behavioral abnormality in Alzheimer’s pathology

  K. Murakami

  Alzheimer's Association International Conference (AAIC) 2013 in Boston, USA, Jul. 2013

  
• ビタミンCによるアルツハイマー病態緩和

  村上一馬

  2013年度日本農芸化学会大会（仙台）, Mar. 2013

  
• Cytoplasmic SOD Deficiency Promotes the Formation of Amyloid Beta Oligomer and Memory Impairment in a Mouse Model of Alzheimer's Disease

  Takahiko Shimizu; Kazuma Murakami; Hiroyuki Hatsuta; Shigeo Murayama; Kazuhiro Irie; Takuji Shirasawa

  FREE RADICAL BIOLOGY AND MEDICINE, Nov. 2012

  
• アミロイドβオリゴマーの形成と空間記憶異常における細胞質SODの役割

  村上一馬

  第31回日本認知症学会学術集会, Oct. 2012

  
• Aβ42“毒性コンホマー”の形成は細胞内酸化ストレスを誘導する

  泉尾直孝; 久米利明; 佐藤瑞穂; 村上一馬; 入江一浩; 泉安彦; 赤池昭紀

  次世代を担う創薬・医療薬理シンポジウム 2012, Sep. 2012

  
• 17 Specific Inhibitory Mechanism of Aβ42 Aggregation by Catechol-Type Flavonoids(Oral Presentation)

  Murakami Kazuma; Sato Mizuho; Ikubo Haruko; Uno Mayumi; Nakagawa Yu; Katayama Sumie; Akagi Ken-ichi; Masuda Yuichi; Takegoshi Kiyonori; Irie Kazuhiro

  Symposium on the Chemistry of Natural Products, symposium papers, Sep. 2012, Peer-reviewed

  
• Aβ42“毒性コンホマー”の形成による細胞内酸化ストレスの誘導

  泉尾直孝; 久米利明; 佐藤瑞穂; 村上一馬; 入江一; 泉安彦; 赤池昭紀

  第31回日本認知症学会学術集会, Jul. 2012

  
• アミロイド β ペプチドの毒性ターン構造の同定とその構造特異抗体の開発

  村上一馬

  第47回天然物化学談話会, 熊本, Jul. 2012, Peer-reviewed

  
• Monoclonal antibody against a toxic conformer of Aβ42 with a turn at E22-D23.

  Irie, K; Murakami, K; Kinoshita, N; Shirasawa, T; Shimizu, T; Tokuda, T

  Alzheimer’s Association International Conference 2012, Vancouver, Canada, Jul. 2012, Peer-reviewed

  
• CuZn-SOD loss accelerates the formation of amyloid β oligomer and memory impairment in Tg2576 mice

  Murakami, K; Murata, N; Noda, Y; Tahara, S; Kaneko, T; Kinoshita, N; Hatsuta, H; Murayama, S; Barnham, Kevin J; Irie, K; Shirasawa, T; Shimizu, T

  Alzheimer’s Association International Conference, Vancouver, Canada, Jul. 2012, Peer-reviewed

  
• 寄生植物由来化合物のアミロイドβ凝集阻害活性に関する研究

  栗栖真奈美; 宮前友策; 木立恵利; 村上一馬; Han Junkyu; 礒田博子; 入江一浩; 繁森英幸

  新規素材探索研究会, Jun. 2012

  
• アミロイド β誘発神経毒性における 22,23位でのターン構造の重要性

  泉尾直孝; 久米利明; 佐藤瑞穂; 村上一馬; 入江一浩; 泉安彦; 赤池昭紀

  第 85回日本薬理学会年会, Mar. 2012

  
• ヤセウツボ（Orobanche miner）由来化合物のアミロイドβ凝集阻害活性に関する研究

  栗栖真奈美; 宮前友策; 村上一馬; Han Junkyu; 礒田博子; 入江一浩; 繁森英幸

  日本農芸化学会2012年度大会, Mar. 2012

  
• 細胞質酸化ストレスによるアミロイド β オリゴマー形成能および記憶異常の促進

  村上一馬; 村田 央; 野田義博; 田原正一; 金子孝夫; 木下憲明; 初田裕幸; 村山繁雄; 入江一浩; 白澤卓二; 清水孝彦

  日本農芸化学会2012年度大会, 京都, Mar. 2012, Peer-reviewed

  
• 細胞質局在型SODの減少はアミロイドβオリゴマー形成と記憶障害を促進する

  清水孝彦; 清水孝彦; 村上一馬; 村上一馬; 村田央; 野田義博; 初田裕幸; 村山繁雄; 入江一浩; 白澤卓二

  日本分子生物学会年会プログラム・要旨集(Web), 2012

  
• 固体NMRおよびESRによるアミロイドβの立体構造解析と毒性ターン構造特異抗体の開発

  村上 一馬; 増田 裕一; 入江 一浩

  遺伝子医学MOOK, 2012, Peer-reviewed, Invited

  
• 抗酸化ストレスに着目したアルツハイマー病予防の可能性

  村上一馬

  原子炉実験所専門研究会（熊取）, Nov. 2011

  
• 大阪変異によるアミロイド β の毒性コンホマー形成能の増大．

  村上一馬; 鈴木啓之; 泉尾直孝; 久米利明; 赤池昭紀; 永田 徹; 西崎知之; 富山貴美; 森 啓; 入江一浩

  第30回日本認知症学会学術集会, 東京., Nov. 2011, Peer-reviewed

  
• Silymarin attenuated the amyloid β deposition and improved behavioral abnormalities in a mouse model of Alzheimer’s disease.

  Shimizu, T; Murakami, K; Murata, N; Ozawa, Y; Irie, K; Shirasawa, T

  41st Annual Meeting of Society for Neuroscience, Washington DC, USA, Nov. 2011, Peer-reviewed

  
• カフェオイルキナ酸のアミロイドβ凝集阻害活性及び分子機構

  宮前友策; 栗栖真奈美; 村上一馬; 入江一浩; Han Junkyu; 礒田博子; 繁森英幸

  第52回天然有機化合物討論会, Sep. 2011, Peer-reviewed

  
• Antibody against toxic conformer of Alzheimer β.

  Murakami, K; Horikoshi-Sakuraba, Y; Kinoshita, N; Shirasawa, T; Shimizu, T; Irie, K

  22nd French-Japanese Symposium on Medicinal and Fine Chemistry, Rouen, France, Sep. 2011, Peer-reviewed

  
• Inhibitory mechanism of amyloid β aggregation by flavonoids.

  Sato, M; Murakami, K; Ikubo, H; Masuda, Y; Takegoshi, K; Irie, K

  27th International Symposium on the Chemistry of Natural Products (ISCNP27)/7th International Conference on Biodiversity (ICOB7), Brisbane, Australia, Jul. 2011, Peer-reviewed

  
• E22Δ mutation promotes the oformation of toxic conformer in Alzheimer’s peptide, Aβ42.

  Murakami, K; Suzuki, T; Yamaguchi, T; Izuo, N; Kume, T; Akaike, A; Nagata, T; Nishizaki, T; Tomiyama, T; Takuma, H; Mori, H; Irie, K

  27th International Symposium on the Chemistry of Natural Products (ISCNP27)/7th International Conference on Biodiversity (ICOB7), Brisbane, Australia, Jul. 2011, Peer-reviewed

  
• Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice.

  Kazuma Murakami; Shin-ichi Yokoyama; Nakaba Murata; Yusuke Ozawa; Kazuhiro Irie; Takuji Shirasawa; Takahiko Shimizu

  Biochemical and biophysical research communications, 27 May 2011, Peer-reviewed

  
• アミロイド β のGlu22欠損による毒性コンホマー形成能の促進

  村上一馬; 鈴木啓之; 泉尾直孝; 久米利明; 赤池昭紀; 永田 徹; 西崎知之; 富山貴美; 森 啓; 入江一浩

  日本農芸化学会2011年度大会, 京都, Mar. 2011, Peer-reviewed

  
• Monoclonal antibody against the toxic turn structure of the 42-mer amyloid β peptide.

  Murakami, K; Horikoshi-Sakuraba, Y; Murata, N; Noda, Y; Masuda, Y; Kinoshita, N; Hatsuta, H; Murayama, S; Shirasawa, T; Shimizu, T; Irie, K

  The 2010 International Chemical Congress of Pacific Basin Societies, Honolulu HI, USA, Dec. 2010, Peer-reviewed

  
• アミロイド β の毒性ターン構造特異的抗体．

  村上一馬; 堀越優子; 村田 央; 野田義博; 増田裕一; 木下憲明; 初田裕幸; 村山繁雄; 白澤卓二; 清水孝彦; 入江一浩

  第29回日本認知症学会学術集会, 名古屋, Nov. 2010, Peer-reviewed

  
• SilymarinによるADモデルマウスの行動異常及びAβ オリゴマー形成の改善．

  村上一馬; 村田 央; 小澤裕介; 木下憲明; 入江一浩; 白澤卓二; 清水孝彦

  日本農芸化学会2010年度関西支部大会, 大阪, Oct. 2010, Peer-reviewed

  
• アミロイド β（Αβ42）の毒性コンホマー特異的抗体の作製

  村上一馬; 堀越優子; 村田 央; 野田義博; 増田裕一; 木下憲明; 初田裕幸; 村山繁雄; 白澤卓二; 清水孝彦; 入江一浩

  第52回天然有機化合物討論会, 静岡, Sep. 2010, Peer-reviewed

  
• アミロイド β の毒性コンホマーを標的とした立体構造特異的抗体．

  村上一馬; 堀越優子; 村田 央; 野田義博; 増田裕一; 木下憲明; 初田裕幸; 村山繁雄; 白澤卓二; 清水孝彦; 入江一浩

  日本農芸化学会2010年度大会, 東京, Mar. 2010, Peer-reviewed

  
• Silyamarin inhibits neurotoxicity and aggregation of the 42-mer amyloid-β peptide.

  村田 央; 村上一馬; 横山慎也; 入江一浩; 白澤卓二; 清水孝彦

  第32回日本分子生物学会年会, 横浜, Dec. 2009, Peer-reviewed

  
• RNA Aptamers Generated against Oligomeric A beta 40 Recognize Common Amyloid Aptatopes with Low Specificity but High Sensitivity

  Farid Rahimi; Kazuma Murakami; Jamie L. Summers; Chi-Hong B. Chen; Gal Bitan

  PLOS ONE, Nov. 2009, Peer-reviewed

  
• CuZn-SOD欠損マウスにおける皮膚の菲薄化およびコラーゲン形成異常.

  清水孝彦; 村上一馬; 稲垣 潤; 斎藤 充; 池田泰隆; 津田千鶴; 野田義博; 川上 哲; 白澤卓二

  第32回日本基礎老化学会年会, 横浜, Jun. 2009, Peer-reviewed

  
• 細胞質SOD欠損マウスにおける皮膚の菲薄化.

  清水孝彦; 村上一馬; 稲垣 潤; 斎藤 充; 池田泰隆; 津田千鶴; 野田義博; 川上 哲; 白澤卓二

  第9回日本抗加齢医学会総会, May 2009, Peer-reviewed

  
• アミロイドβのAsp23における異性化あるいはラセミ化が凝集能および神経細胞毒性に及ぼす影響

  村上一馬; 宇野真弓; 増田裕一; 清水孝彦; 白澤卓二; 入江一浩

  日本農芸化学会年2009年度大会, 福岡, Mar. 2009, Peer-reviewed

  
• Development of a monoclonal antibody against the toxic conformer of the 42-mer amyloid β protein

  Kazuma Murakami

  39th Annual Meeting of Society for Neuroscience (Chicago, USA), 2009

  
• β アミロイドの毒性コンホメーションのESRならびに固体NMRによる検証.

  入江一浩; 村上一馬; 増田裕一; 上村諭子; 原 英之; 中西 梓; 大橋竜太郎; 竹腰清乃理

  第27回日本認知症学会, 前橋, Oct. 2008, Peer-reviewed

  
• Aptamers selected against monomeric Aβ40 recognize other amyloid proteins.

  Summers, J. L; Rahimi, F; Murakami, K; Bitan, G

  22nd Annual Symposium of the Protein Society, San Diego, USA, Jul. 2008, Peer-reviewed

  
• Isomerization and/or racemization at Asp23 of A beta 42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro

  Kazuma Murakami; Mayumi Uno; Yuichi Masuda; Takahiko Shimizu; Takuji Shirasawa; Kazuhiro Irie

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2008, Peer-reviewed

  
• アミロイドβペプチドのターン構造形成とアスパラギン酸残基修飾

  清水孝彦; 村上一馬; 宇野真弓; 入江一浩; 白澤卓二

  第80回日本生化学会大会ワークショップ, Dec. 2007, Peer-reviewed

  
• Distance analysis between Tyr-10 and Met-35 in amyloid β using site-directed spin labeling ESR: implications for the stronger neurotoxicity of Aβ42 than Aβ40.

  Murakami, K; Hara, H; Irie, K

  37th Annual Meeting of Society for Neuroscience, San Diego, CA, USA, Nov. 2007, Peer-reviewed

  
• 固体NMRならびにESRによるアミロイド β (Aβ42) の毒性コンホメーションの解析.

  入江一浩; 増田裕一; 村上一馬; 上村諭子; 原 英之; 大橋竜太郎; 中西 梓; 竹腰清乃理

  第 49回天然有機化合物討論会, 北海道, Sep. 2007, Peer-reviewed

  
• ラジカル産生を介した β アミロイドの神経細胞毒性発現機構.

  村上一馬

  日本農芸化学会 2007年度大会, 東京, Mar. 2007, Peer-reviewed

  
• ‘Malignant’ conformation of Alzheimer’s β peptides (Aβ42) through radical formation.

  Murakami, K; Irie, K; Ohigashi, H; Hara, H; Nagao, M; Shimizu, T; Shirasawa, T

  International Conference of 43rd Japanese Peptide Symposium, Yokohama, Japan, Nov. 2006, Peer-reviewed

  
• Elucidation of the ‘malignant’ conformation of β-amyloid with Italian mutation (E22K-Aβ42) using solid-state NMR.

  Masuda, Y; Irie, K; Murakami, K; Ohigashi, H; Ohashi, R; Takegoshi, K

  ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products, Kyoto, Japan, Jul. 2006, Peer-reviewed

  
• Formation and stabilization mechanism of the β-amyloid radical.

  Murakami, K; Irie, K; Ohigashi, H; Hara, H; Nagao, M; Shimizu, T; Shirasawa, T

  ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products, Jul. 2006, Peer-reviewed

  
• Application of dipolar-assisted rotational resonance (DARR) to β-amyloid.

  Masuda, Y; Irie, K; Murakami, K; Ohigashi, H; Ohashi, R; ○Takegoshi, K

  The 2005 International Chemical Congress of Pacific Basin Societies, Honolulu, USA, Dec. 2005, Peer-reviewed

  
• Elucidation of the ‘malignant’ conformation of β-amyloid with Italian mutation (E22K-Aβ42) using solid-state NMR: implications for the pathogenesis of cerebral amyloid angiopathy and Alzheimer’s disease.

  Masuda, Y; Irie, K; Murakami, K; Ohigashi, H; Ohashi, R; Takegoshi, K; Shimizu, T; Shirasawa, T

  35th Annual Meeting of Society for Neuroscience, Washington DC, USA, Nov. 2005, Peer-reviewed

  
• New aggregation model of 42-mer amyloid β by the systematic proline replacement.

  Irie, K; Murakami, K; Masuda, Y; Morimoto, A; Ohigashi, H; Hara, H; Nagao, M; Shimizu, T; Shirasawa, T

  35th Annual Meeting of Society for Neuroscience, Washington DC, USA, Nov. 2005, Peer-reviewed

  
• Alzheimer’s 42-mer β peptide-specific mechanism of neurotoxicity through radical formation.

  Murakami, K; Irie, K; Ohigashi, H; Hara, H; Nagao, M; Shimizu, T; Shirasawa, T

  35th Annual Meeting of Society for Neuroscience, Washington DC, USA, Nov. 2005, Peer-reviewed

  
• β アミロイドの新しい凝集モデルに基づく神経細胞毒性発現機構.

  村上一馬; 入江一浩; 森本 晃; 増田裕一; 大東 肇; 永尾雅哉; 清水孝彦; 白澤卓二

  第 47回天然有機化合物討論会, 徳島, Oct. 2005, Peer-reviewed

  
• Aβ42 ラジカルの生成と神経細胞毒性発現機構.

  村上一馬

  第 24 回日本認知症学会, 大阪, Sep. 2005, Peer-reviewed

  
• 系統的プロリン置換による β アミロイドフィブリルの2次構造解析

  村上一馬

  日本農芸化学会 2005 年度大会, 札幌, Mar. 2005, Peer-reviewed

  
• Structural analysis of amyloid β.

  Ohashi, R; Takegoshi, K; Terao, T; Masuda, Y; Murakami, K; Irie, K

  XXI International Conference on Magnetic Resonance in Biological Systems, (Hyderabad, Andhra Pradesh, India),, Jan. 2005

  
• New aggregation model of amyloid β by the systematic proline replacement.

  Murakami, K; Irie, K; Morimoto, A; Masuda, Y; Ohigashi, H; Nagao, M; Fukuda, H; Shimizu, T; Shirasawa, T

  1st Asia-Pacific International Peptide Symposium, 41st Japanese Peptide Symposium, Fukuoka, Japan, Nov. 2004, Peer-reviewed

  
• β アミロイド (Aβ42) の新しい凝集モデル

  村上一馬

  第 37 回若手ペプチド夏の勉強会, 京都, Aug. 2004, Peer-reviewed

  
• プロリン置換による Aβ42 凝集体の立体構造解析.

  村上一馬

  日本農芸化学会 2004 年度大会, 広島, Mar. 2004, Peer-reviewed

  
• β アミロイドの新しい凝集モデル

  村上一馬

  第 22 回日本認知症学会, Oct. 2003, Peer-reviewed

  
• β アミロイドの新しい凝集仮説.

  村上一馬

  第 38 回天然物化学談話会, 福岡, Jul. 2003, Peer-reviewed

  
• 家族性アルツハイマー病因 β アミロイドの凝集活性および神経細胞毒性.

  村上一馬

  日本農芸化学会 2003 年度大会, 東京, Apr. 2003, Peer-reviewed

  
• 家族性アルツハイマー病因ペプチドの化学合成、凝集活性および神経細胞毒性

  村上一馬

  第 37 回天然物化学談話会, 京都, Jul. 2002, Peer-reviewed

  
• 家族性アルツハイマー β ペプチドの合成、凝集活性および神経細胞毒性.

  村上一馬

  日本農芸化学会 2002 年度大会, 仙台, Mar. 2002, Peer-reviewed

  

Presentations

• 似た者どうしはひっつきやすい。これ、⼈間だけじゃなくタンパク質でもそうなんです

  村上一馬

  京大100人論文

  
• Development of RNA aptamers for supersulfide amyloid and superchalcogenides

  Thi Hong Van Nguyen; Kazuma Murakami

  超硫黄研究フロンティアシンポジウム2024, 04 Dec. 2024

  
• メタアグリゲートと病態蛋白質の学術変革

  村上一馬

  2025年度日本農芸化学会年会, 07 Mar. 2025, Invited

  
• BLIを用いたアミロイドタンパク質に結合する核酸アプタマーの認識機構解析

  村上一馬

  ザルトリウスライフサイエンスアカデミー2024, 12 Dec. 2024, Invited

  
• メタアグリゲートと病態蛋白の学術変革

  村上一馬

  第43回日本認知症学術集会, 22 Nov. 2024, Invited

  
• メタアグリゲートと病態蛋白の学術変革

  村上一馬

  京都大学複合原子力科学専門研究会「第15回タンパク質の異常凝集とその防御・修復機構に関する研究会」, 28 Aug. 2024, Invited

  
• 京都大学へようこそ〜自由と学問の聖地で研究者になろう〜

  村上一馬

  清風中学講演会, 21 Aug. 2024, Invited

  
• 【アミロイドとタンパク質】分子進化法によるメタアグリゲートの網羅的探索と検証

  村上一馬

  学術変革領域研究 (B)「メタアグリゲートの超分子挙動と動的キャプチャー」公開シンポジウム, 24 May 2024, Invited

  
• Advances in nucleic acid biochemistry research on meta-aggregates of amyloidogenic proteins

  Kazuma Murakami

  The 2nd International G-ReXS Conference in Sendai, 20 May 2024, Invited

  
• αシヌクレインを認識するRNAアプタマー

  村上一馬

  第13回 DSANJ Digital Bio Conference 2024, 25 Jan. 2024, Invited

  
• リシン標的型凝集阻害剤：抗認知症薬としての展望

  村上一馬

  第42回日本認知症学会学術集会（シンポジウム27：新しい分析ツールでひも解く次代のmisfolding病研究）, 25 Nov. 2023, Invited

  
• アミロイド疾患の分子標的治療を目指した核酸生物化学研究

  村上一馬

  第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会合同大会（シンポジウム：多様なアミロイド凝集体による神経変性メカニズムの解明）＊学術変革領域研究（B）「メタアグリゲートの超分子挙動と動的キャプチャー」との共催, 06 Jul. 2023, Invited

  
• 核酸研究から見えてきた新たなAD病態：核酸アプタマー医薬の創製と応用

  村上一馬

  第64回日本神経学会学術大会（シンポジウム14：注目されているアルツハイマー病の新たな病態研究）, 01 Jun. 2023, Invited

  
• メタアグリゲートに関する核酸生物化学研究

  村上一馬

  金沢大学脳神経内科第41回Neuroscience Seminar, 12 May 2023, Invited

  
• アミロイド蛋白質を認識する核酸アプタマー

  村上一馬

  京都大学複合原子力科学専門研究会「第14回タンパク質の異常凝集とその防御・修復機構に関する研究会」, 10 Mar. 2023, Invited

  
• アミロイドタンパク質を認識する核酸アプタマー

  村上一馬

  日本薬学会北陸支部特別講演会, 27 Jan. 2023, Invited

  
• Development of RNA aptamers that recognizes amyloid key structures

  Kazuma Murakami

  UCLA Department of Neurology Seminar, 07 Nov. 2022, Invited

  
• アミロイド凝集を阻害する天然物の論理的探索法

  村上一馬

  第19回ファンクショナルフード学会学術集会, 07 Jan. 2023, Invited

  
• Synthesis of conformation-restricted analogues of amyloid persulfide toward their application to nucleic acid medicine

  Kazuma Murakami; Masayoshi Mochizuki; Taku Yoshiya; Naotaka Izuo

  Redox Week in Sendai2022 (The 12th International NO Conference & The 22nd NOSJ), 30 Oct. 2022

  
• 超硫黄化アミロイドに特異的な核酸プローブとエクソソームを用いた高感度検出法の開発

  村上一馬

  学術変革領域研究（A）新興硫黄生物学が拓く生命原理変革（硫黄生物学）第２回領域会議, 06 Aug. 2022

  
• アミロイドタンパク質を認識する核酸アプタマーの創製と応用

  村上一馬

  2022年度日本農芸化学会オンラインシンポジウム, 17 Mar. 2022

  
• Classification of amyloid β aggregation inhibitors from natural product library

  Kazuma Murakami; Shiori Horii; Tatsuto Sadamitsu; Yoshiki Sakaguchi; Kota Taniwa; Mizuho Hanaki; Hiroki Gunji; Kazuhiro Irie

  Pacifichem2020, 22 Dec. 2021

  
• アミロイドタンパク質を認識するRNAアプタマーの治療・診断応用に向けて〜"アミロイド結合性核酸"の創薬応用〜

  村上一馬; 小畑弥生; 入江一浩

  27 Jun. 2021

  
• アミロイドβ42の毒性オリゴマーを認識するRNAアプタマーの開発

  村上一馬; 小畑弥生; 関川あさ; 上田遥; 川瀬泰司; 廣瀬賢治; 泉尾直孝; 清水孝彦; 入江一浩

  第62回天然有機化合物討論会, 24 Sep. 2020

  
• アミロイドβの凝集を抑える天然物の3つの特徴

  村上一馬

  日本食品科学工学会関西支部大会, 26 Oct. 2019, Invited

  
• Session Chairs of Molecular and Cell Biology: Aβ/amyloid (O3-01-01~06)

  Kazuma Murakami; Lucía Chávez-Gutiérrez

  Alzheimer's Association International Conference 2019, 16 Jul. 2019

  
• Strategy for development of RNA aptamers that target the toxic oligomer of Aβ42

  Murakami, K; Obata, Y; Sekikawa, A; Ueda, H; Izuo, N; Awano, T; Takabe, K; Shimizu, T; Irie, K

  Alzheimer's Association International Conference 2019, 16 Jul. 2019

  
• Strategy for development of RNA aptamers targeting the toxic oligomer of Aβ42: toward prevention of oligomeropathy

  村上 一馬

  UCLA Mini-symposium "Oligomers in Alzheimer's disease: Elucidation of disease mechanisms and development of therapeutics", 12 Jul. 2019

  
• RNA aptamers targeting the toxic oligomers of Aβ42 and their application to immunohistochemistry

  Kazuma Murakami; Yayoi Obata; Asa Sekikawa; Haruka Ueda; Naotaka Izuo; Tatsuya Awano; Keiji Takabe; Takahiko Shimizu; Kazuhiro Irie

  The 45th International Syposium on Nucleic Acids Chemistry, 07 Nov. 2018, Invited

  
• Inhibitory mechanism of amyloid β42 aggregation by traditional herbal medicine and functional food components.

  Kazuma Murakami

  Zhejiang University–Kyoto University Joint Workshop, 27 Nov. 2017, Invited

  
• オリゴマー仮説の視点からバイオマーカーを考える：アミロイドβの毒性配座理論

  村上一馬

  第36回日本認知症学術集会, 24 Nov. 2017, Invited

  
• アミロイドβの毒性配座理論と抗体創製

  村上一馬

  認知症研究を知る若手研究者の集まり2017, 29 Jul. 2017, Invited

  
• アミロイドβの毒性配座抗体とその診断応用

  村上一馬

  筑波大学特別講義（天然有機化合物と創薬R&D）, 05 Dec. 2016, Invited

  
• 天然ポリフェノールによるAβ42凝集阻害機構の解明とアルツハイマー病予防の可能性

  村上一馬

  第35回日本認知症学術集会, 03 Dec. 2016, Invited

  
• アミロイドβのラジカル化：アルツハイマー病態におけるSOD1の役割

  村上一馬

  第11回レドックス・ライフイノベーションシンポジウム, 17 Mar. 2016, Invited

  
• アミロイドβの抗毒性コンホマー抗体とその診断応用の可能性

  村上一馬

  昭和大学学士会後援セミナー, 16 Mar. 2016, Invited

  
• Characterization of monoclonal antibodies against the toxic turn of amyloid β42 and their application to diagnosis for Alzheimer's disease.

  Kazuma Murakami; Mizuho Hanaki; Maria Luisa Moro; Giorgio Giaccone; Fabrizio Tagliavini; Ken-ichi Akagi; Ryotaro Ishii; Takahiko Tokuda; Masahiro Maeda; Naotaka Izuo; Takahiko Shimizu; Kazuhiro Irie

  2015 International Chemical Congress of Pacific Basin Societies (PACICHEM 2015), 15 Dec. 2015, Invited

  
• アミロイドβの毒性配座理論に基づいた構造特異抗体の開発と診断薬への応用

  村上一馬

  京都大学原子炉実験所専門研究会「第8回タンパク質の異常凝集とその防御・修復機構に関する研究会」, 19 Nov. 2015, Invited

  
• アミロイドβペプチドの毒性配座理論に基づいた立体構造特異抗体の開発と診断薬への応用

  村上一馬

  第47回若手ペプチド夏の勉強会, 11 Aug. 2015, Invited

  
• アミロイドβペプチドの毒性コンホマー特異抗体の開発と診断薬への応用

  村上一馬

  第50回天然物化学談話会, 02 Jul. 2015, Invited

  
• 認知症の食品予防に関する化学的研究

  村上一馬

  京都大学オープンキャンパス2015, 02 Jul. 2015, Invited

  
• アミロイドβを標的としたアルツハイマー病の新しい治療戦略

  村上一馬

  日本農芸化学会中部支部第172回例会, 22 Nov. 2014, Invited

  
• アミロイドβの毒性オリゴマー認識薬開発への挑戦

  村上一馬

  日本農芸化学会関西支部例会（第483回講演）, 01 Mar. 2014, Invited

  
• 酸化ストレスに着目したアミロイドβペプチドの神経細胞毒性発現機構

  村上一馬

  新学術領域天然物ケミカルバイオロジー「化学と生物学の壁と打開策：次世代天然物ケミカルバイロジー研究の開拓へ」地区ミニシンポジウム, 01 Feb. 2014, Invited

  
• ポリフェノールによるアミロイドβの凝集抑制メカニズム

  村上一馬

  京都大学原子炉実験所専門研究会「第6回タンパク質の異常凝集とフォールディング病」, 13 Nov. 2013, Invited

  
• ポリフェノールによるアミロイドβの凝集阻害機構

  村上一馬

  生理化学研究ユニット第3回シンポジウム, 02 Jul. 2013, Invited

  
• 抗酸化ストレスに着目したアルツハイマー病予防の可能性

  京都大学原子炉実験所専門研究会「タンパク質の異常凝集とフォールディング病」, 10 Nov. 2011, 京都大学原子炉実験所

  
• アミロイドβ異常凝集における「折れ曲がり」の役割

  京都大学原子炉実験所専門研究会 「タンパク質の異常凝集とフォールディング病」, 12 Nov. 2010, 京都大学原子炉実験所(大阪)

  
• アルツハイマー病と機能性食品因子 （Alzheimer’s disease and functional foods）

  Invited Lecturer in Gwangju University, 13 Oct. 2010, Gwangju大学 (Gwangju, 韓国)

  
• Structural analysis of toxic conformer of 42-mer amyloid β peptide using ESR spectrometry

  7th Asia-Pacific EPR/ESR Symposium, 12 Oct. 2010, Convention Center (Jeju, 韓国)

  
• Development of a monoclonal antibody against the toxic conformer of the 42-mer amyloid β protein.

  Kazuma Murakami; Yuko Horikoshi-Sakuraba; Nakaba Murata; Yoshihiro Noda; Yuichi Masuda; Noriaki Kinoshita; Hiroyuki Hatsuta; Shigeo Murayama; Takuji Shirasawa; Takahiko Shimizu; Kazuhiro Irie

  39th Annual Meeting of Society for Neuroscience (Chicago), 18 Oct. 2009, Invited

  
• ‘Toxic’ turn formation at positions 22 and 23 in Aβ42 and its relevance to oxidative stress in AD

  Neurodegeneration Research Meeting, 14 Aug. 2009, Melbourne大学 (Melbourne, Australia)

  

Books and Other Publications

• 実験医学増刊Vol.41, No.12「いま新薬で加速する神経変性疾患研究」

  村上一馬, Contributor, 第1章タンパク質構造と病態（1ー 2：アミロイドの核形成過程の制御分子群）

  羊土社, Jul. 2023

  Find Kyoto University's collection of books :

  
• New Tide of Natural Product Chemistry

  Kazuma Murakami, Contributor, Part IV New Approach for Drug Discovery Using Natural Products; Chapter 15 High-Throughput Searches for Natural Products as Aggregation Modulators of Amyloidogenic Proteins

  Springer Singapore, 20 Jun. 2023

  Find Kyoto University's collection of books :

  
• アミロイドβの「毒性コンホマー」形成とGlu22における遺伝性変異．

  村上一馬; 佐藤瑞穂; 鈴木啓之; 泉尾直孝; 久米利明; 赤池昭紀; 永田 徹; 西崎知之; 富山貴美; 森 啓; 入江一浩, Single work

  Dementia Japan 26 (3), 311-318 (2012)., 2012, Not refereed

  
• アミロイド β の毒性ターン構造を認識する抗体の開発

  村上一馬; 入江一浩, Single work

  神経内科 77 (2), 179-184 (2012)., 2012, Not refereed

  
• Cytoplasmic superoxide radicals as contributing factors to intracellular Aβ oligomerization in Alzheimer’s disease

  Murakami, K; Shimizu, T, Single work

  Commun. Integr. Biol. 5 (3), 255-258 (2012)., 2012, Not refereed

  
• 固体NMRおよびESRによるアミロイド β の立体構造解析と毒性ターン構造特異抗体の開発.

  村上一馬; 増田裕一; 入江一浩, Single work

  遺伝子医学MOOK「最新ペプチド合成技術とその創薬研究への応用」 21, 211-216 (2012), 2012, Not refereed

  
• 抗酸化ストレスに着目したアルツハイマー病予防の可能性.

  村上一馬; 入江一浩; 清水孝彦, Single work

  タンパク質の異常凝集とその防御・修復機構に関する研究会報告, 4, 10-14 (2011)., 2011, Not refereed

  
• アミロイド β の毒性ターン構造を認識する抗体の開発.

  入江一浩; 村上一馬; 増田裕一; 村田 央; 野田義博; 初田裕幸; 村山繁雄; 清水孝彦; 堀越優子; 木下憲明; 白澤卓二, Single work

  臨床神経 51 (3), 25-29 (2011)., 2011, Not refereed

  
• Formation of the 42-mer amyloid β radical and the therapeutic role of superoxide dismutase in Alzheimer’s disease.

  Murakami, K; Shimizu, T; Irie, K, Single work

  J. Amino Acids 2011, doi: 10.4061/2011/654207 (2011)., 2011, Not refereed

  
• アミロイドβ異常凝集における「折れ曲がり」の役割

  村上一馬; 入江一浩, Single work

  タンパク質の異常凝集とその防御・修復機構に関する研究会報告（III）, 2010, Not refereed

  
• The turn formation at positions 22 and 23 in the 42-mer amyloid β peptide: the merging role in the pathogenesis of Alzheimer’s disease.

  Murakami, K; Masuda; Y. Shirasawa, T; Shimizu, T; Irie, K, Single work

  Geriatr. Gerontol. Int. 10 (Suppl. 1), S169-S179 (2010)., 2010, Not refereed

  
• Amyloids and protein aggregation – analytical methods.

  Li, H; Rahimi, F; Sinha, S; Maiti, P; Bitan, G; Murakami, K, Single work

  Encyclopedia Anal. Chem. doi: 10.1002/9780470027318.a9038 (2009)., 2009, Not refereed

  
• アミロイド β (Aβ42) の毒性コンホメーションの提唱.

  村上一馬; 清水孝彦; 白澤卓二; 入江一浩, Single work

  基礎老化研究 32 (3), 25-29 (2008)., 2008, Not refereed

  
• The toxic conformation of the 42-residue amyloid β peptide and its relevance to oxidative stress in Alzheimer’s disease.

  Irie, K; Murakami, K; Masuda, Y; Morimoto, A; Ohigashi, H; Hara, H; Ohashi, R; Takegoshi K; Fukuda, H; Nagao, M; Shimizu, T; Shirasawa, T, Single work

  Mini-Rev. Med. Chem. 7 (10), 1001-1008 (2007)., 2007, Not refereed

  
• Young investigator’s competition in Yokohama ~‘Malignant conformation of Aβ42 peptide’.

  村上一馬, Single work

  PEPTIDE NEWSLETTER JAPAN 63 (1), 5-8 (2007)., 2007, Not refereed

  
• ‘Malignant’ conformation of Alzheimer’s β peptides (Aβ42) through radical formation.

  Murakami, K; Irie, K; Ohigashi, H; Hara, H; Nagao, M; Shimizu, T; Shirasawa, T, Single work

  In Peptide Science 2006, eds. Ishida, H. & Mihara, H., The Japanese Peptide Society, 19-20 (2006)., 2006, Not refereed

  
• Structure of β-amyloid fibrils and its relevance to their neurotoxicity: implications for the pathogenesis of Alzheimer’s disease.

  Irie, K; Murakami, K; Masuda, Y; Morimoto, A; Ohigashi, H; Ohashi, R; Takegoshi, K; Nagao, M; Shimizu, T; Shirasawa, T, Single work

  J. Biosci. Bioeng. 99 (5), 437-447 (2005)., 2005, Not refereed

  
• New aggregation model of amyloid β by the systematic proline replacement.

  Murakami, K; Irie, K; Morimoto, A; Masuda, Y; Ohigashi, H; Nagao, M; Fukuda, H; Shimizu, T; Shirasawa, T, Single work

  In Peptide Science 2004, ed. Shimohigashi, Y., The Japanese Peptide Society, 179-182 (2005)., 2005, Not refereed

  

Industrial Property Rights

• 特願国際出願PCT/JP2024/4974, RNAアプタマー

  村上一馬

  
• 特願2023—023603, RNAアプタマー

  村上一馬

  
• 特願2014-251898,2015-104411, アミロイドβの22位及び23位のターン構造を極めて特異的に認識する抗体

  入江一浩; 村上一馬; 清水孝彦; 泉尾直孝; 清藤 勉

  
• 特許US 8,710,193; CN ZL201080046483.9, 特願特願2009-239542,国際特許出願PCT/JP2010/006162, Antibody recognizing turn structure in amyloid β

  Irie, K; Murakami, K; Masuda, Y; Shimizu, T; Shirasawa, T; Seito, T

  
• 特願2009-239542, アミロイドβのターン構造を認識する抗体

  入江一浩; 村上一馬; 増田裕一; 清水孝彦; 白澤卓二; 清藤 勉

  

Awards

• Aug. 2004

  日本ペプチド学会, 第37回若手ペプチド夏の勉強会最優秀発表賞
• Oct. 2005

  第47回天然有機化合物討論会奨励賞
• Jul. 2006

  IUPAC天然物化学国際会議ICOB-5&ISCNP-25 poster prize
• Nov. 2006

  The Japanese Peptide Society, 第43回ペプチド討論会&第4回ペプチド工学国際会議若手奨励賞
• Jun. 2008

  日本基礎老化学会, 第31回日本基礎老化学会奨励賞
• Jun. 2008

  Japan Society for Biomedical Gerontology, 2010年度日本農芸化学会大会トピックス賞（共同受賞，筆頭発表者：村上一馬）
• Sep. 2010

  第52回天然有機化合物討論会奨励賞
• Jul. 2012

  第12回天然物談話会奨励賞
• Mar. 2013

  Japan Society for Bioscience, Biotechnology, Agrochemistry, 2013年度農芸化学奨励賞
• Mar. 2013

  日本農芸化学会, Biosci. Biotechnol. Biochem.誌論文賞（共同受賞，筆頭発表者：村上一馬）
• Mar. 2013

  Japan Society for Bioscience, Biotechnology, Agrochemistry, 2013年度日本農芸化学会大会トピックス賞（共同受賞，筆頭発表者：村上一馬）
• 30 Nov. 2018

  36th Medicinal Chemistry Symposium, DMC, PSJ in 2018, Award for Excellent Presentation, 36th Medicinal Chemistry Symposium, DMC, PSJ in 2018 (Collaboration)
• Sep. 2016

  日本学術振興会, 科研費審査委員表彰
• Apr. 2013

  日本農芸化学会, 2018年度日本農芸化学会大会トピックス賞（共同受賞，筆頭発表者：坂口嘉紀）
• Mar. 2019

  日本農芸化学会, 2019年度日本農芸化学会大会ポスター発表選出（共同受賞，筆頭発表者：村上一馬）
• Mar. 2020

  日本農芸化学会, 2020年度日本農芸化学会大会ポスター発表選出（共同受賞，筆頭発表者：村上一馬）
• 30 Sep. 2016

  日本学術振興会, 平成28年度科研費　審査委員表彰

External funds: Kakenhi

• [Amyloid and protein] Comprehensive search and validation of meta-aggregates by molecular evolutionary method

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (III)

  Kyoto University

  村上 一馬

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  RNA結合タンパク質;アミロイド;神経変性疾患;計算科学;高速AFM;分子進化

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-23H03852/
• Supramolecular behavior and dynamic capture of meta-aggregates

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (III)

  Kyoto University

  村上 一馬

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  研究推進;若手支援;アウトリーチ;国際共同研究;女性活躍

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-23H03849/
• Structural chemistry of intracellular recognition by nucleic acid aptamers and brain barrier permeation strategies for the treatment of neurodegenerative disease

  Grant-in-Aid for Scientific Research (B)

  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related

  Kyoto University

  村上 一馬

  From 01 Apr. 2023, To 31 Mar. 2027, Granted

  アプタマー;エクソソーム;神経変性疾患;NMR;ドラッグデリバリーシステム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02093/
• Supramolecular behavior and dynamic capture of metastable amyloid aggregates

  Grant-in-Aid for Transformative Research Areas (B)

  From 01 Apr. 2023, To 31 Mar. 2026

  https://kaken.nii.ac.jp/grant/KAKENHI-AREA-23B304/
• Development of highly sensitive detection method for supersulfide amyloid using nucleic acid probe and exosome

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  村上 一馬

  From 16 Jun. 2022, To 31 Mar. 2024, Declined

  アプタマー;エクソソーム;神経変性疾患;超硫黄;核酸医薬;国際共同研究;ペプチド合成;診断薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22H05564/
• International research project on nucleic acid aptamers and their exosome-based application to therapeutics for synucleinopathy

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Kyoto University

  Kazuma Murakami

  From 27 Oct. 2020, To 31 Mar. 2023, Project Closed

  アプタマー;エクソソーム;神経変性疾患;計算科学;核酸医薬;ドラッグデリバリーシステム;αシヌクレイン;国際共同研究

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20KK0126/
• Bioorganic studies on the genotoxicity of colibactin produced from human microbiome in colorectal cancer

  Grant-in-Aid for Scientific Research (C)

  Basic Section 38040:Bioorganic chemistry-related

  Kyoto University

  Kazuma Murakami

  From 01 Apr. 2020, To 31 Mar. 2024, Project Closed

  腸内細菌;バイオーム分子;天然物化学;コリバクチン;ヒューミマイシン;標的探索;プロバイオティクス;片利共生;抗菌活性;大腸がん;有機合成化学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K05849/
• Very early diagnosis of Alzheimer's disease by the toxic oligomer specific antibody of amyloid beta

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Kyoto University

  Kazuhiro Irie

  From 01 Apr. 2019, To 31 Mar. 2024, Project Closed

  アルツハイマー病;アミロイドβ;抗毒性ターン特異抗体;毒性オリゴマー;分子内ジスルフィド架橋;有機化学;ジスルフィド架橋;２量体;脳神経疾患;抗体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H00921/
• Unified comprehension of chemical communication by natural PKC ligands and development of new medicinal seeds

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Science and Engineering

  Kyoto University

  Kazuhiro Irie

  From 30 Jun. 2017, To 31 Mar. 2022, Project Closed

  プロテインキナーゼＣ;発がんプロモーター;ホルボールエステル;アプリシアトキシン;機械学習;アロタケタール;HIV;アルツハイマー病;シグナル伝達;癌;有機化学;薬理学;酵素;プロテインキナーゼC;CH/π相互作用;マクラマイシン;ヒト免疫不全ウイルス;がん細胞増殖抑制

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-17H06405/
• Structural organic chemistry in inhibitory mechanism of amyloid beta oligomerization

  Grant-in-Aid for Young Scientists (A)

  Kyoto University

  Kazuma Murakami

  From 01 Apr. 2016, To 31 Mar. 2020, Project Closed

  脳神経疾患;アルツハイマー病;有機合成化学;漢方生薬;オリゴマー;アミロイドβ;NMR;質量分析;有機化学;天然物バンク;生薬;代謝

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H06194/
• Search for novel target molecules of intracellular amyloid beta

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Kazuma Murakami

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  アルツハイマー病;アミロイドβ;オリゴマー;標的探索;MS/MS;シグナル伝達;ビオチン化;磁性ビーズ;siRNA

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K12744/
• Novel Preventive Strategy for Alzheimer's Disease Based on the Toxic Conformation Theory of Amyloid beta

  Grant-in-Aid for Scientific Research (S)

  Kyoto University

  Kazuhiro Irie

  From 30 May 2014, To 31 Mar. 2019, Project Closed

  アルツハイマー病;アミロイドβ;毒性ターン;凝集;抗体;脳脊髄液;診断;フラボノイド;脳神経疾患;有機化学;核酸アプタマー;ノックインマウス;毒性オリゴマー;アルツハイマー;オリゴマー;神経細胞毒性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26221202/
• Identification of amyloid beta aggregation inhibitors in a traditional herbal medicine Uncaria rhynchophylla and their inhibitory mechanism

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Kazuma MURAKAMI

  From 01 Apr. 2013, To 31 Mar. 2015, Project Closed

  アルツハイマー病;アミロイドβ;凝集;漢方生薬;単離構造決定;チョウトウコウ;トリテルペン;NMR;カギカズラ;構造決定;トリテルペノイド

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25850080/
• 33S solid-state NMR analysis of methionine radical inducing cytotoxicity of amyloid-beta protein

  Grant-in-Aid for Young Scientists (B)

  Tohoku University

  YUICHI MASUDA

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  有機化学;アミロイド;固体NMR;硫黄;ラジカル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24780108/
• Development of RNA aptamer against toxic Aβ oligomer

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Kazuma MURAKAMI

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  アルツハイマー病;アミロイド β;凝集;オリゴマー;アプタマー;RNA;アミロイドβ;核酸アプタマー;ジアミノピペリン酸;Huisgen反応;白金;プロドラッグ;フイスゲン反応;アジド;アルキン;細胞質SOD;スーパーオキシドラジカル;光親和性標識;ラジカル;酸化ストレス;ビタミンC;インスリン受容体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22603006/
• Development of medicinal seeds for Alzheimer's disease based on the structural analysis of toxic oligomers of amyloid beta

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Kazuhiro IRIE

  From 01 Apr. 2009, To 31 Mar. 2014, Project Closed

  アルツハイマー病;アミロイドβ;凝集;毒性ターン;抗体;フラボノイド;オリゴマー;アルツハイマー;凝集抑制;カテコール;Aβ42;βアミロイド;タキシフォリン;プロテインキナーゼC;クルクミン;シナプス毒性;アプリシアトキシン;抗ターン抗体;毒性コンホマー;光アフィニティーラベリング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21248015/
• Supramolecular behavior and dynamic capture of metastable amyloid aggregates

  Grant-in-Aid for Transformative Research Areas (B)

  From 01 Apr. 2023, To 31 Mar. 2026

  https://kaken.nii.ac.jp/grant/KAKENHI-AREA-23B304/
• Structural chemistry of intracellular recognition by nucleic acid aptamers and brain barrier permeation strategies for the treatment of neurodegenerative diseases

  Grant-in-Aid for Scientific Research (B)

  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related

  Kyoto University

  村上 一馬

  From 01 Apr. 2023, To 31 Mar. 2027, Granted

  核酸アプタマー;エクソソーム;神経変性疾患;NMR;ドラッグデリバリーシステム;アプタマー;核酸医薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K26786/
• Exploring supersulfide that mediates energy metabolism and redox signaling

  Grant-in-Aid for Scientific Research (S)

  Broad Section H

  Tohoku University

  赤池 孝章

  From 01 Apr. 2024, To 31 Mar. 2029, Granted

  超硫黄分子;超硫黄カテネーション;エネルギー代謝;過酸化脂質ラジカル;酸化ストレス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24H00063/
• International research project on the role of amyloid supersulfide in neurodegenerative diseases

  Fund for the Promotion of Joint International Research (International Collaborative Research)

  Medium-sized Section 37:Biomolecular chemistry and related fields

  Kyoto University

  村上 一馬

  From 09 Sep. 2024, To 31 Mar. 2029, Granted

  アミロイド;神経変性疾患;超硫黄分子;国際共同研究;エクソソーム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24KK0115/
• Elucidation of the pathological significance of Abeta protofibrils in Alzheimer's disease using human biological samples

  Grant-in-Aid for Scientific Research (B)

  Basic Section 52020:Neurology-related

  Kanazawa University

  小野 賢二郎

  From 01 Apr. 2025, To 31 Mar. 2028, Granted

  アルツハイマー病;アミロイドβ;プロトフィブリル;レカネマブ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25K02578/

External funds: others

• 腸内細菌由来⾮天然ペプチドによる感染症治療の標的探索

  第52回内藤記念科学振興財団奨励⾦

  From 01 Apr. 2021, To 31 Mar. 2022

  村上一馬
• 生薬由来化合物をリードにしたアミロイドβオリゴマー特異的な 核磁気共鳴イメージングプローブの開発

  第37回松籟科学技術振興財団研究助成

  From 01 Oct. 2019, To 30 Sep. 2021

  村上一馬
• Aβ毒性コンホマーの細胞内標的タンパク質

  2012年度上原記念生命科学財団研究奨励金

  From 01 Apr. 2013, To 31 Mar. 2014

  村上一馬
• 光親和性標識法及び固体NMR法を用いたアミロイドβ凝集阻害機構の解明

  第22回加藤記念バイオサイエンス振興財団研究助成

  From 01 Apr. 2011, To 30 Mar. 2013

  村上一馬

Education

Teaching subject(s)

• From 01 Apr. 2025, To 31 Mar. 2026

  Basic Organic Chemistry I

  N347, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Outline of Physiological Chemistry

  M212, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Advanced Course of Bioorganic Chemistry

  GA25, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar on Organic Chemistry

  7315, Fall, Faculty of Agriculture, 1
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar of Organic Chemistry in Life Science

  GF03, Fall, Graduate School of Agriculture, 1.5
• From 01 Apr. 2025, To 31 Mar. 2026

  Seminar of Organic Chemistry in Life Science

  GF03, Spring, Graduate School of Agriculture, 1.5
• From 01 Apr. 2025, To 31 Mar. 2026

  Laboratory Course in Organic Chemistry in Food Science

  7280, Spring, Faculty of Agriculture, 3
• From 01 Apr. 2025, To 31 Mar. 2026

  Experimental Course of Organic Chemistry in Life Science

  GG03, Spring, Graduate School of Agriculture, 3
• From 01 Apr. 2025, To 31 Mar. 2026

  Experimental Course of Organic Chemistry in Life Science

  GG03, Fall, Graduate School of Agriculture, 3
• From 01 Apr. 2025, To 31 Mar. 2026

  Outline of Physiological Chemistry

  X101, Fall, Graduate School of Agriculture, 2
• From 01 Apr. 2025, To 31 Mar. 2026

  Analytical Chemistry in Food Science

  7299, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Organic Chemistry I

  N347, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Course of Natural Products Chemistry

  GA26, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar on Organic Chemistry

  7315, Fall, Faculty of Agriculture, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar of Organic Chemistry in Life Science

  GF03, Spring, Graduate School of Agriculture, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar of Organic Chemistry in Life Science

  GF03, Fall, Graduate School of Agriculture, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course of Organic Chemistry in Life Science

  GG03, Fall, Graduate School of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course of Organic Chemistry in Life Science

  GG03, Spring, Graduate School of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Course in Organic Chemistry in Food Science

  7280, Spring, Faculty of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Analytical Chemistry in Food Science

  7299, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Organic Chemistry I

  N347, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Course of Bioorganic Chemistry

  GA25, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar on Organic Chemistry

  7315, Fall, Faculty of Agriculture, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Course in Organic Chemistry in Food Science

  7280, Spring, Faculty of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar of Organic Chemistry in Life Science1

  GB13, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar of Organic Chemistry in Life Science2

  GB14, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course of Organic Chemistry in Life Science2

  GC14, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course of Organic Chemistry in Life Science1

  GC13, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Analytical Chemistry in Food Science

  7299, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course of Organic Chemistry in Life Science1

  GC13, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Organic Chemistry I

  N347, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Course of Natural Products Chemistry

  GA26, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Course in Organic Chemistry in Food Science

  7280, Spring, Faculty of Agriculture, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course of Organic Chemistry in Life Science2

  GC14, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Analytical Chemistry in Food Science

  7299, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar on Organic Chemistry

  7315, Fall, Faculty of Agriculture, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar of Organic Chemistry in Life Science2

  GB14, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar of Organic Chemistry in Life Science1

  GB13, Year-long, Graduate School of Agriculture, 3
• From Apr. 2011, To Mar. 2012

  有機化学実験及び実験法

  Spring, 農学部
• From Apr. 2011, To Mar. 2012

  生命有機化学

  Spring, 農学部
• From Apr. 2011, To Mar. 2012

  食品有機化学III

  Fall, 農学部
• From Apr. 2011, To Mar. 2012

  生命有機化学専攻実験

  農学研究科
• From Apr. 2011, To Mar. 2012

  生命有機化学専攻演習

  農学研究科
• From Apr. 2012, To Mar. 2013

  Organic Chemistry in Life Science

  Spring, 農学部
• From Apr. 2012, To Mar. 2013

  Organic Chemistry in Food Science III

  Fall, 農学部
• From Apr. 2012, To Mar. 2013

  Laboratory Course in Organic Chemistry in Food Science

  Spring, 農学部
• From Apr. 2013, To Mar. 2014

  Organic Chemistry in Food Science III

  Fall, 農学部
• From Apr. 2013, To Mar. 2014

  Organic Chemistry in Life Science

  Spring, 農学部
• From Apr. 2013, To Mar. 2014

  Laboratory Course in Organic Chemistry in Food Science

  Spring, 農学部
• From Apr. 2013, To Mar. 2014

  Seminar of Organic Chemistry in Life Science

  Year-long, 農学研究科
• From Apr. 2013, To Mar. 2014

  Experimental Course of Organic Chemistry in Life Science

  Year-long, 農学研究科
• From Apr. 2014, To Mar. 2015

  Organic Chemistry in Life Science

  Spring, 農学部
• From Apr. 2014, To Mar. 2015

  Laboratory Course in Organic Chemistry in Food Science

  Spring, 農学部
• From Apr. 2014, To Mar. 2015

  Analytical Chemistry in Food Science

  Fall, 農学部
• From Apr. 2014, To Mar. 2015

  Organic Chemistry in Life Science

  Spring, 農学研究科
• From Apr. 2014, To Mar. 2015

  Seminar of Organic Chemistry in Life Science

  Year-long, 農学研究科
• From Apr. 2014, To Mar. 2015

  Experimental Course of Organic Chemistry in Life Science

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Organic Chemistry in Life Science

  Spring, 農学部
• From Apr. 2015, To Mar. 2016

  Experimental Course of Organic Chemistry in Life Science1

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Experimental Course of Organic Chemistry in Life Science

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Seminar of Organic Chemistry in Life Science1

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Seminar of Organic Chemistry in Life Science

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Analytical Chemistry in Food Science

  Fall, 農学部
• From Apr. 2015, To Mar. 2016

  Laboratory Course in Organic Chemistry in Food Science

  Spring, 農学部
• From Apr. 2016, To Mar. 2017

  Basic Organic Chemistry I

  Spring, 全学共通科目
• From Apr. 2016, To Mar. 2017

  Natural Products Chemistry

  Spring, 農学部
• From Apr. 2016, To Mar. 2017

  Organic Chemistry in Life Science

  Spring, 農学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course of Organic Chemistry in Life Science1

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course of Organic Chemistry in Life Science2

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course of Organic Chemistry in Life Science

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Seminar of Organic Chemistry in Life Science1

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Seminar of Organic Chemistry in Life Science2

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Seminar of Organic Chemistry in Life Science

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Analytical Chemistry in Food Science

  Fall, 農学部
• From Apr. 2016, To Mar. 2017

  Laboratory Course in Organic Chemistry in Food Science

  Spring, 農学部
• From Apr. 2017, To Mar. 2018

  Basic Organic Chemistry I

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Natural Products Chemistry

  Spring, 農学部
• From Apr. 2017, To Mar. 2018

  Experimental Course of Organic Chemistry in Life Science1

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course of Organic Chemistry in Life Science2

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Seminar of Organic Chemistry in Life Science1

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Seminar of Organic Chemistry in Life Science2

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Course of Bioorganic Chemistry

  Spring, 農学研究科
• From Apr. 2017, To Mar. 2018

  Analytical Chemistry in Food Science

  Fall, 農学部
• From Apr. 2017, To Mar. 2018

  Laboratory Course in Organic Chemistry in Food Science

  Spring, 農学部
• From Apr. 2018, To Mar. 2019

  Basic Organic Chemistry I

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Natural Products Chemistry

  Spring, 農学部
• From Apr. 2018, To Mar. 2019

  Advanced Course of Natural Products Chemistry

  Spring, 農学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course of Organic Chemistry in Life Science1

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course of Organic Chemistry in Life Science2

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Seminar of Organic Chemistry in Life Science1

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Seminar of Organic Chemistry in Life Science2

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Outline of Physiological Chemistry

  Fall, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Analytical Chemistry in Food Science

  Fall, 農学部
• From Apr. 2018, To Mar. 2019

  Laboratory Course in Organic Chemistry in Food Science

  Spring, 農学部
• From Apr. 2019, To Mar. 2020

  Basic Organic Chemistry I

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Seminar on Organic Chemistry

  Fall, 農学部
• From Apr. 2019, To Mar. 2020

  Experimental Course of Organic Chemistry in Life Science1

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course of Organic Chemistry in Life Science2

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Seminar of Organic Chemistry in Life Science1

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Seminar of Organic Chemistry in Life Science2

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Course of Bioorganic Chemistry

  Spring, 農学研究科
• From Apr. 2019, To Mar. 2020

  Analytical Chemistry in Food Science

  Fall, 農学部
• From Apr. 2019, To Mar. 2020

  Laboratory Course in Organic Chemistry in Food Science

  Spring, 農学部
• From Apr. 2020, To Mar. 2021

  Basic Organic Chemistry I

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Advanced Course of Natural Products Chemistry

  Spring, 農学研究科
• From Apr. 2020, To Mar. 2021

  Seminar on Organic Chemistry

  Spring, 農学部
• From Apr. 2020, To Mar. 2021

  Experimental Course of Organic Chemistry in Life Science1

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course of Organic Chemistry in Life Science2

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Seminar of Organic Chemistry in Life Science1

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Seminar of Organic Chemistry in Life Science2

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Analytical Chemistry in Food Science

  Fall, 農学部
• From Apr. 2020, To Mar. 2021

  Laboratory Course in Organic Chemistry in Food Science

  Year-long, 農学部
• From Apr. 2021, To Mar. 2022

  Basic Organic Chemistry I

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Seminar on Organic Chemistry

  Fall, 農学部
• From Apr. 2021, To Mar. 2022

  Experimental Course of Organic Chemistry in Life Science1

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course of Organic Chemistry in Life Science2

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Seminar of Organic Chemistry in Life Science1

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Seminar of Organic Chemistry in Life Science2

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Course of Bioorganic Chemistry

  Spring, 農学研究科
• From Apr. 2021, To Mar. 2022

  Analytical Chemistry in Food Science

  Fall, 農学部
• From Apr. 2021, To Mar. 2022

  Laboratory Course in Organic Chemistry in Food Science

  Spring, 農学部

Student achievements: Awards

• 2018年度日本農芸化学会大会トピックス賞（共同）

  坂口嘉紀, 日本農芸化学会, 27 Mar. 2018

Part-time lecturer

• From 09 Apr. 2014, To 30 Sep. 2014

  天然物有機化学

  集中, 広島大学, 大学院理学研究科
• From 08 Apr. 2015, To 30 Sep. 2015

  天然物有機化学

  集中, 広島大学, 大学院理学研究科
• From 08 Apr. 2016, To 30 Sep. 2016

  天然物有機化学

  集中, 広島大学, 大学院理学研究科
• From 01 Dec. 2016, To 31 Mar. 2017

  天然有機化合物と創薬R&D

  期間内2回, 筑波大学, 生命環境科学研究科
• From 10 Apr. 2017, To 30 Sep. 2017

  天然物有機化学

  集中, 広島大学, 大学院理学研究科
• From 09 Apr. 2018, To 30 Sep. 2018

  天然物有機化学

  集中, 広島大学, 大学院理学研究科
• From 08 Apr. 2019, To 30 Sep. 2019

  天然物有機化学

  集中, 広島大学, 大学院統合生命科学研究科

Administration

School management (title, position)

• From 01 Apr. 2017, To 31 Mar. 2019

  環境管理専門委員会有機廃液情報管理小委員会　委員
• From 01 Apr. 2015, To 31 Mar. 2021

  放射線障害予防小委員会　委員
• From 01 Apr. 2019, To 31 Mar. 2023

  放射線障害予防小委員会　委員
• From 01 Apr. 2019, To 31 Mar. 2021

  環境管理専門委員会有機廃液情報管理小委員会　委員

Faculty management (title, position)

• From 01 Apr. 2023, To 31 Mar. 2025

  男女共同参画推進委員会　委員
• From 01 Apr. 2023, To 31 Mar. 2027

  図書委員会　委員
• From 01 Oct. 2010

  放射線取扱主任者（農学研究科）
• From 01 Oct. 2010

  エックス線作業主任者（農学研究科）
• From 01 Apr. 2014, To 31 Mar. 2016

  広報委員会　委員
• From 01 Apr. 2014, To 31 Mar. 2016

  研究活動推進委員会　委員
• From 01 Apr. 2015, To 31 Mar. 2027

  動物実験委員会　委員
• From 01 Apr. 2016, To 31 Mar. 2018

  環境・安全・衛生委員会　委員
• From 01 Apr. 2015

  放射線障害防止委員会　委員
• From 01 Apr. 2018, To 31 Mar. 2020

  広報委員会　委員

Academic, Social Contribution

Committee Memberships

• From Apr. 2019, To Present

  参与, 日本農芸化学会 関西支部
• From Nov. 2022, To Present

  代議員, 日本認知症学会
• From Jun. 2020, To May 2022

  代議員, 日本農芸化学会
• From Oct. 2009, To Jul. 2024

  天然物化学談話会世話人（2022.8~副代表）

Academic Contribution

• International Journal of Molecular Sciences (Guest Editor)

  Peer review

  From 2022, To Present

  
• Frontiers in Molecular Neuroscience (Editorial Board)

  Peer review

  From 2020, To Present

  
• PLoS One (Editorial Board)

  Peer review

  From 2019, To Present