Basic Information

Faculty

• 農学部

Professional Memberships

• 細胞生物学会
• 生化学会
• 農芸化学会

Academic Degree

• 農学修士(京都大学)
• 博士（農学）(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院農学研究科博士後期課程農芸化学専攻, 修了
• 京都大学, 大学院農学研究科修士課程農芸化学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 京都大学, 農学部農芸化学科, 卒業

Research History

• From Apr. 2019, To Present

  京都大学大学院, 農学研究科, 教授
• From Apr. 2007, To Mar. 2019

  京都大学大学院, 農学研究科, 准教授
• From Jul. 2003, To Mar. 2007

  京都大学大学院, 農学研究科, 助教授
• From Apr. 1991, To Jun. 2003

  Kyoto University, 農学部/農学研究科, 助手
• From Jul. 1994, To Jul. 1996

  NIDR, NIH, USA

Language of Instruction

• English

ID,URL

• ORCID ID

  0000-0002-2708-537X

• J-Global ID

  200901013889095469

researchmap URL

• https://researchmap.jp/read0013042

Research

Research Topics, Overview of the research

• Research Topics

  Mechanisms by which cell-extracellular matrix adhesion regulates cell behavior and cell fate.

• Overview of the research

  Our human body is composed of 37 trillion cells. In addition to cells, various non-cellular components including proteins and sugars that surround cells are also major constituents of the body. These non-cellular components called extracellular matrix regulate various cellular behaviors and fates (cell growth, migration, and differentiation) as extracellular environments. Cells cooperate with each other to maintain homeostasis in vivo. These regulation and cooperation are prerequisite for multicellular organisms. Abnormalities in regulation and cooperation in the body lead to various diseases such as cancer.
  The goal of my research is to understand the mechanisms of various “cellular” and physiological events from the viewpoint of “biochemistry” of genes and proteins. In particular, I have been analyzing the mechanism by which extracellular matrix, such as collagen, regulate cell growth and differentiation.

Research Interests

• 細胞生物学
• 分子生物学
• Cell Biology
• Molecular Biology

Research Areas

• Life sciences, Applied molecular and cellular biology
• Life sciences, Applied biochemistry
• Life sciences, Cell biology

Papers

• Expression in HEK293 cells, purification, and characterization of recombinant human α-glucosidases

  So Nishimoto; Teisuke Takita; Kazumichi M Nishida; Masaaki Ito; Toshiyuki Kimura; Yasuhisa Kimura; Noriyuki Kioka; Kiyoshi Yasukawa

  Bioscience, Biotechnology, and Biochemistry, 16 Apr. 2025

  
• The ATPase activity of ABCA1 is increased by cholesterol in the presence of anionic lipids

  Kazuki Sakata; Noriyuki Kioka; Kazumitsu Ueda; Yasuhisa Kimura

  The Journal of Biochemistry, 31 May 2024

  
• The plasma membrane of focal adhesions has a high content of cholesterol and phosphatidylcholine with saturated acyl chains.

  Hiroshi Tachibana; Kodai Minoura; Tomohiro Omachi; Kohjiro Nagao; Takafumi Ichikawa; Yasuhisa Kimura; Nozomu Kono; Yuta Shimanaka; Hiroyuki Arai; Kazumitsu Ueda; Noriyuki Kioka

  Journal of cell science, 15 Aug. 2023

  
• Cholesterol accumulation in ovarian follicles causes ovulation defects in Abca1a Japanese medaka (Oryzias latipes)

  Ryota Futamata; Masato Kinoshita; Katsueki Ogiwara; Noriyuki Kioka; Kazumitsu Ueda

  Heliyon, Feb. 2023

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• The role of ATP hydrolysis in conformational changes of human P-glycoprotein in living cells

  Ryota Futamata; Fumihiko Ogasawara; Takafumi Ichikawa; Atsushi Kodan; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  bioRxiv, Nov. 2019

  
• がんの転移,浸潤,および細胞骨格形成制御における新規細胞膜裏打ちタンパク質ビネキシンの機能解析

  木岡 紀幸

  日本農芸化学会誌, 01 Jun. 2000

  
• ABCB1/MDR1/P-gp employs an ATP-dependent twist-and-squeeze mechanism to export hydrophobic drugs.

  Atsushi Kodan; Ryota Futamata; Yasuhisa Kimura; Noriyuki Kioka; Toru Nakatsu; Hiroaki Kato; Kazumitsu Ueda

  FEBS letters, Mar. 2021

  
• Live Cell FRET Analysis of the Conformational Changes of Human P-glycoprotein.

  Ryota Futamata; Noriyuki Kioka; Kazumitsu Ueda

  Bio-protocol, 20 Feb. 2021

  
• ABCA13 dysfunction associated with psychiatric disorders causes impaired cholesterol trafficking.

  Mitsuhiro Nakato; Naoko Shiranaga; Maiko Tomioka; Hitomi Watanabe; Junko Kurisu; Mineko Kengaku; Naoko Komura; Hiromune Ando; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  The Journal of biological chemistry, 16 Dec. 2020

  
• Stiffness of the extracellular matrix regulates differentiation into beige adipocytes.

  Kyoko Takata; Tsuyoshi Goto; Mito Kuroda; Yasuhisa Kimura; Ichiro Harada; Kazumitsu Ueda; Teruo Kawada; Noriyuki Kioka

  Biochemical and biophysical research communications, 05 Nov. 2020, Peer-reviewed

  
• In vivo FRET analyses reveal a role of ATP hydrolysis–associated conformational changes in human P-glycoprotein

  Ryota Futamata; Fumihiko Ogasawara; Takafumi Ichikawa; Atsushi Kodan; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  Journal of Biological Chemistry, 10 Apr. 2020, Peer-reviewed

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• C-terminal of ABCA1 separately regulates cholesterol floppase activity and cholesterol efflux activity.

  Okamoto Y; Tomioka M; Ogasawara F; Nagaiwa K; Kimura Y; Kioka N; Ueda K

  Bioscience, biotechnology, and biochemistry, Dec. 2019, Peer-reviewed

  
• Changes in the asymmetric distribution of cholesterol in the plasma membrane influence streptolysin O pore formation

  Fumihiko Ogasawara; Fumi Kano; Masayuki Murata; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  Scientific Reports, 14 Mar. 2019, Peer-reviewed

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• Roles of the Mesenchymal Stromal/Stem Cell Marker Meflin in Cardiac Tissue Repair and the Development of Diastolic Dysfunction.

  Akitoshi Hara; Hiroki Kobayashi; Naoya Asai; Shigeyoshi Saito; Takahiro Higuchi; Katsuhiro Kato; Takahiro Okumura; Yasuko K Bando; Mikito Takefuji; Yasuyuki Mizutani; Yuki Miyai; Shoji Saito; Shoichi Maruyama; Keiko Maeda; Noriyuki Ouchi; Arata Nagasaka; Takaki Miyata; Shinji Mii; Noriyuki Kioka; Daniel L Worthley; Toyoaki Murohara; Masahide Takahashi; Atsushi Enomoto

  Circulation research, 02 Aug. 2019

  
• Phosphorylation by protein kinase C stabilizes ABCG1 and increases cholesterol efflux.

  Watanabe T; Kioka N; Ueda K; Matsuo M

  Journal of biochemistry, May 2019, Peer-reviewed

  
• How ATP is used by P-glycoprotein to export multiple hydrophobic compounds

  Ryota Futamata; Fumihiko Ogasawara; Takafumi Ichikawa; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  May 2019

  
• Cell migration is negatively modulated by ABCA1.

  Ito S; Kioka N; Ueda K

  Bioscience, biotechnology, and biochemistry, Mar. 2019, Peer-reviewed

  
• Apolipoprotein A-I directly interacts with extracellular domain 1 of human ABCA1

  Kawanobe, T.; Shiranaga, N.; Kioka, N.; Kimura, Y.; Ueda, K.

  Bioscience, Biotechnology and Biochemistry, Mar. 2019, Peer-reviewed

  
• An amphipathic helix of vinexin α is necessary for a substrate stiffness-dependent conformational change in vinculin

  Naoya Hino; Takafumi Ichikawa; Yasuhisa Kimura; Michiyuki Matsuda; Kazumitsu Ueda; Noriyuki Kioka

  Journal of Cell Science, Jan. 2019, Peer-reviewed

  
• Temporary sequestration of cholesterol and phosphatidylcholine within extracellular domains of ABCA1 during nascent HDL generation

  Masato Ishigami; Fumihiko Ogasawara; Kohjiro Nagao; Hidehiko Hashimoto; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  Scientific Reports, 01 Dec. 2018, Peer-reviewed

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• Vinexin family (SORBS) proteins regulate mechanotransduction in mesenchymal stem cells

  Kuroda; M. Ueda; K., Kioka, N

  Scientific Reports, 2018, Peer-reviewed

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• Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation

  Takafumi Ichikawa; Masahiro Kita; Tsubasa S. Matsui; Ayaka Ichikawa Nagasato; Tomohiko Araki; Shian-Huey Chiang; Takuhito Sezaki; Yasuhisa Kimura; Kazumitsu Ueda; Shinji Deguchi; Alan R. Saltiel; Noriyuki Kioka

  JOURNAL OF CELL SCIENCE, Oct. 2017, Peer-reviewed

  
• Lysophosphatidylcholine export by human ABCA7

  Maiko Tomioka; Yoshinobu Toda; Noralyn B. Manucat; Hiroyasu Akatsu; Manabu Fukumoto; Nozomu Kono; Hiroyuki Arai; Noriyuki Kioka; Kazumitsu Ueda

  BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, Jul. 2017, Peer-reviewed

  
• Lysophosphatidylcholine export by human ABCA7

  Tomioka, M.; Toda, Y.; Ma{\~n}ucat, N.B.; Akatsu, H.; Fukumoto, M.; Kono, N.; Arai, H.; Kioka, N.; Ueda, K.

  Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Jul. 2017, Peer-reviewed

  
• Lysophosphatidylcholine export by human ABCA7.

  Maiko Tomioka; Yoshinobu Toda; Noralyn B Mañucat; Hiroyasu Akatsu; Manabu Fukumoto; Nozomu Kono; Hiroyuki Arai; Noriyuki Kioka; Kazumitsu Ueda

  Biochimica et biophysica acta. Molecular and cell biology of lipids, Jul. 2017, Peer-reviewed

  
• Cellular force assay detects altered contractility caused by a nephritis-associated mutation in nonmuscle myosin IIA

  Shota P. Fukuda; Tsubasa S. Matsui; Takafumi Ichikawa; Taichi Furukawa; Noriyuki Kioka; Shuichiro Fukushima; Shinji Deguchi

  DEVELOPMENT GROWTH & DIFFERENTIATION, Jun. 2017, Peer-reviewed

  
• Vinculin association with actin cytoskeleton is necessary for stiffness-dependent regulation of vinculin behaviore

  Tomohiro Omachi; Takafumi Ichikawa; Yasuhisa Kimura; Kazumitsu Ueda; Noriyuki Kioka

  PLOS ONE, Apr. 2017, Peer-reviewed

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• Fluid shear stress applied by orbital shaking induces MG-63 osteosarcoma cells to activate ERK in two phases through distinct signaling pathways

  Takashi Fukada; Hiroki Sakajiri; Mito Kuroda; Noriyuki Kioka; Kenji Sugimoto

  Biochemistry and Biophysics Reports, 01 Mar. 2017, Peer-reviewed

  
• Vinculin promotes nuclear localization of TAZ to inhibit ECM stiffness-dependent differentiation into adipocytes

  Mito Kuroda; Hiroki Wada; Yasuhisa Kimura; Kazumitsu Ueda; Noriyuki Kioka

  JOURNAL OF CELL SCIENCE, Mar. 2017, Peer-reviewed

  
• The distribution of vinculin to lipid rafts plays an important role in sensing stiffness of extracellular matrix

  Ayaka Ichikawa Nagasato; Hiroshi Yamashita; Michinori Matsuo; Kazumitsu Ueda; Noriyuki Kioka

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 2017, Peer-reviewed

  
• ABCG1 and ABCG4 Suppress gamma-Secretase Activity and Amyloid beta Production

  Osamu Sano; Maki Tsujita; Yuji Shimizu; Reiko Kato; Aya Kobayashi; Noriyuki Kioka; Alan T. Remaley; Makoto Michikawa; Kazumitsu Ueda; Michinori Matsuo

  PLOS ONE, May 2016, Peer-reviewed

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• Neurite outgrowth stimulation by n-3 and n-6 PUFAs of phospholipids in apoE-containing lipoproteins secreted from glial cells

  Mitsuhiro Nakato; Michinori Matsuo; Nozomu Kono; Makoto Arita; Hiroyuki Arai; Jun Ogawa; Noriyuki Kioka; Kazumitsu Ueda

  JOURNAL OF LIPID RESEARCH, Oct. 2015, Peer-reviewed

  
• Position 834 in TM6 plays an important role in cholesterol and phosphatidylcholine transport by ABCA1

  Shimpei Itoh; Kohjiro Nagao; Yasuhisa Kimura; Michinori Matsuo; Noriyuki Kioka; Kazumitsu Ueda

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, May 2015, Peer-reviewed

  
• ABCB4 exports phosphatidylcholine in a sphingomyelin-dependent manner

  Yu Zhao; Masato Ishigami; Kohjiro Nagao; Kentaro Hanada; Nozomu Kono; Hiroyuki Arai; Michinori Matsuo; Noriyuki Kioka; Kazumitsu Ueda

  JOURNAL OF LIPID RESEARCH, Mar. 2015, Peer-reviewed

  
• Loss of Dlg5 expression promotes the migration and invasion of prostate cancer cells via Girdin phosphorylation

  L. Tomiyama; T. Sezaki; M. Matsuo; K. Ueda; N. Kioka

  ONCOGENE, Feb. 2015, Peer-reviewed

  
• Fomiroid A, a Novel Compound from the Mushroom Fomitopsis nigra, Inhibits NPC1L1-Mediated Cholesterol Uptake via a Mode of Action Distinct from That of Ezetimibe

  Tomohiro Chiba; Tsuyoshi Sakurada; Rie Watanabe; Kohji Yamaguchi; Yasuhisa Kimura; Noriyuki Kioka; Hirokazu Kawagishi; Michinori Matsuo; Kazumitsu Ueda

  PLOS ONE, Dec. 2014, Peer-reviewed

  
• ABCA1, ABCG1, and ABCG4 Are Distributed to Distinct Membrane Meso-Domains and Disturb Detergent-Resistant Domains on the Plasma Membrane

  Osamu Sano; Shiho Ito; Reiko Kato; Yuji Shimizu; Aya Kobayashi; Yasuhisa Kimura; Noriyuki Kioka; Kentaro Hanada; Kazumitsu Ueda; Michinori Matsuo

  PLOS ONE, Oct. 2014, Peer-reviewed

  
• The role of the interaction of the vinculin proline-rich linker region with vinexin alpha in sensing the stiffness of the extracellular matrix

  Hiroshi Yamashita; Takafumi Ichikawa; Daisuke Matsuyama; Yasuhisa Kimura; Kazumitsu Ueda; Susan W. Craig; Ichiro Harada; Noriyuki Kioka

  JOURNAL OF CELL SCIENCE, May 2014, Peer-reviewed

  
• Small-Molecule-Induced Clustering of Heparan Sulfate Promotes Cell Adhesion

  Naohiro Takemoto; Tetsuya Suehara; Heidie L. Frisco; Shin-ichi Sato; Takuhito Sezaki; Kosuke Kusamori; Yoshinori Kawazoe; Sun Min Park; Sayumi Yamazoe; Yoshiyuki Mizuhata; Rintaro Inoue; Gavin J. Miller; Steen U. Hansen; Gordon C. Jayson; John M. Gardiner; Toshiji Kanaya; Norihiro Tokitoh; Kazumitsu Ueda; Yoshinobu Takakura; Noriyuki Kioka; Makiya Nishikawa; Motonari Uesugi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2013, Peer-reviewed

  
• 24(S)-hydroxycholesterol is actively eliminated from neuronal cells by ABCA1

  Akihiro Matsuda; Kohjiro Nagao; Michinori Matsuo; Noriyuki Kioka; Kazumitsu Ueda

  Journal of Neurochemistry, Jul. 2013, Peer-reviewed

  
• Dlg5 interacts with the TGF-β receptor and promotes its degradation

  Takuhito Sezaki; Lucia Tomiyama; Yasuhisa Kimura; Kazumitsu Ueda; Noriyuki Kioka

  FEBS Letters, 05 Jun. 2013, Peer-reviewed

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• ATPase activity of nucleotide binding domains of human MDR3 in the context of MDR1

  M. Ishigami; Y. Tominaga; K. Nagao; Y. Kimura; M. Matsuo; N. Kioka; K. Ueda

  Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Apr. 2013, Peer-reviewed

  
• ATPase activity of nucleotide binding domains of human MDR3 in the context of MDR1

  Masato Ishigami; Yuko Tominaga; Kohjiro Nagao; Yasuhisa Kimura; Michinori Matsuo; Noriyuki Kioka; Kazumitsu Ueda

  Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, Apr. 2013

  
• Non-Specific Protein Modifications by a Phytochemical Induce Heat Shock Response for Self-Defense

  Kohta Ohnishi; Shinya Ohkura; Erina Nakahata; Akari Ishisaka; Yoshichika Kawai; Junji Terao; Taiki Mori; Takeshi Ishii; Tsutomu Nakayama; Noriyuki Kioka; Shinya Matsumoto; Yasutaka Ikeda; Minoru Akiyama; Kazuhiro Irie; Akira Murakami

  PLOS ONE, Mar. 2013, Peer-reviewed

  
• Vinexin-beta protects against cardiac hypertrophy by blocking the Akt-dependent signalling pathway

  Ke Chen; Lu Gao; Yu Liu; Yan Zhang; Ding-Sheng Jiang; Xiang Wei; Xue Hai Zhu; Rui Zhang; Yingjie Chen; Qinglin Yang; Noriyuki Kioka; Xiao-Dong Zhang; Hongliang Li

  BASIC RESEARCH IN CARDIOLOGY, Mar. 2013, Peer-reviewed

  
• ATPase activity of human ABCG1 is stimulated by cholesterol and sphingomyelin

  Hiroshi Hirayama; Yasuhisa Kimura; Noriyuki Kioka; Michinori Matsuo; Kazumitsu Ueda

  JOURNAL OF LIPID RESEARCH, Feb. 2013, Peer-reviewed

  
• Glyceraldehyde-3-phosphate dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stability

  Yuki Ikeda; Ryoichi Yamaji; Kazuhiro Irie; Noriyuki Kioka; Akira Murakami

  ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, Dec. 2012, Peer-reviewed

  
• Role of Dlg5/lp-dlg, a Membrane-Associated Guanylate Kinase Family Protein, in Epithelial-Mesenchymal Transition in LLc-PK1 Renal Epithelial Cells

  Takuhito Sezaki; Kohki Inada; Takayuki Sogabe; Kumiyo Kakuda; Lucia Tomiyama; Yohsuke Matsuno; Takafumi Ichikawa; Michinori Matsuo; Kazumitsu Ueda; Noriyuki Kioka

  PLOS ONE, Apr. 2012, Peer-reviewed

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• ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I binding

  Kohjiro Nagao; Kei Takahashi; Yuya Azuma; Mie Takada; Yasuhisa Kimura; Michinori Matsuo; Noriyuki Kioka; Kazumitsu Ueda

  JOURNAL OF LIPID RESEARCH, Jan. 2012, Peer-reviewed

  
• Liver X Receptor beta (LXR beta) Interacts Directly with ATP-binding Cassette A1 (ABCA1) to Promote High Density Lipoprotein Formation during Acute Cholesterol Accumulation

  Masako Hozoji-Inada; Youichi Munehira; Kohjiro Nagao; Noriyuki Kioka; Kazumitsu Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2011, Peer-reviewed

  
• Liver X Receptor beta (LXR beta) Interacts Directly with ATP-binding Cassette A1 (ABCA1) to Promote High Density Lipoprotein Formation during Acute Cholesterol Accumulation

  Masako Hozoji-Inada; Youichi Munehira; Kohjiro Nagao; Noriyuki Kioka; Kazumitsu Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2011, Peer-reviewed

  
• WAVE2 forms a complex with PKA and is involved in PKA enhancement of membrane protrusions

  Hiroshi Yamashita; Kazumitsu Ueda; Noriyuki Kioka

  Journal of Biological Chemistry, 04 Feb. 2011, Peer-reviewed

  
• WAVE2 Forms a Complex with PKA and Is Involved in PKA Enhancement of Membrane Protrusions

  Hiroshi Yamashita; Kazumitsu Ueda; Noriyuki Kioka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2011, Peer-reviewed

  
• The Closely Related RNA helicases, UAP56 and URH49, Preferentially Form Distinct mRNA Export Machineries and Coordinately Regulate Mitotic Progression

  Tomohiro Yamazaki; Naoko Fujiwara; Hiroko Yukinaga; Miki Ebisuya; Takuya Shiki; Tomoya Kurihara; Noriyuki Kioka; Taiho Kambe; Masaya Nagao; Eisuke Nishida; Seiji Masuda

  MOLECULAR BIOLOGY OF THE CELL, Aug. 2010, Peer-reviewed

  
• Crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo

  Noriyuki Kioka; Takuya Ito; Hiroshi Yamashita; Natsuko Uekawa; Tsutomu Umemoto; Soh Motoyoshi; Hiroshi Imai; Kenzo Takahashi; Hideto Watanabe; Masayasu Yamada; Kazumitsu Ueda

  EXPERIMENTAL CELL RESEARCH, Jun. 2010, Peer-reviewed

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• The role of DLG5 in prostate cancer progression

  Noriyuki Kioka

  69th Annual Meeting of the Japanese Cancer Association, 2010, Peer-reviewed

  
• Tyrosine phosphorylation of vinexin in v-Src-transformed cells attenuates the affinity for vinculin

  Tsutomu Umemoto; Kana Tanaka; Kazumitsu Ueda; Noriyuki Kioka

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2009, Peer-reviewed

  
• v-Src-mediated transformation suppresses the expression of focal adhesion protein vinexin

  Tsutomu Umemoto; Takahiro Inomoto; Kazumitsu Ueda; Michinari Hamaguchi; Noriyuki Kioka

  CANCER LETTERS, Jun. 2009, Peer-reviewed

  
• Formation of Two Intramolecular Disulfide Bonds Is Necessary for ApoA-I-dependent Cholesterol Efflux Mediated by ABCA1

  Masako Hozoji; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2009, Peer-reviewed

  
• The COP9 signalosome controls ubiquitinylation of ABCA1

  Yuya Azuma; Mie Takada; Minami Maeda; Noriyuki Kioka; Kazumitsu Ueda

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2009, Peer-reviewed

  
• Retroendocytosis pathway of ABCA1/apoA-I contributes to HDL formation

  Yuya Azuma; Mie Takada; Hye-Won Shin; Noriyuki Kioka; Kazuhisa Nakayama; Kazumitsu Ueda

  GENES TO CELLS, Feb. 2009, Peer-reviewed

  
• Direct Interaction of Nuclear Liver X Receptor-beta with ABCA1 Modulates Cholesterol Efflux

  Masako Hozoji; Youichi Munehira; Yuika Ikeda; Makoto Makishima; Michinori Matsuo; Noriyuki Kioka; Kazumitsu Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2008, Peer-reviewed

  
• Direct interaction of Cucurbitacin E isolated from Alsomitra macrocarpa to actin filament

  Keiko Momma; Yuko Masuzawa; Naomi Nakai; Moeko Chujo; Akira Murakami; Noriyuki Kioka; Yasunori Kiyama; Toru Akita; Masaya Nagao

  CYTOTECHNOLOGY, Jan. 2008, Peer-reviewed

  
• Sphingomyelin-dependence of cholesterol efflux mediated by ABCG1

  Osamu Sano; Aya Kobayashi; Kohjiro Nagao; Keigo Kumagai; Noriyuki Kioka; Kentaro Hanada; Kazumitsu Ueda; Michinori Matsuo

  JOURNAL OF LIPID RESEARCH, Nov. 2007, Peer-reviewed

  
• Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4

  Shin-ya Morita; Aya Kobayashi; Yasukazu Takanezawa; Noriyuki Kioka; Tetsurou Handa; Hiroyuki Arai; Michinori Matsuo; Kazumitsu Ueda

  HEPATOLOGY, Jul. 2007, Peer-reviewed

  
• Enhanced ApoA-I-dependent cholesterol efflux by ABCA1 from sphingomyelin-deficient chinese hamster ovary cells

  Kohjiro Nagao; Kei Takahashi; Kentaro Hanada; Noriyuki Kioka; Michinori Matsuo; Kazumitsu Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2007, Peer-reviewed

  
• Involvement of phosphatases in the anchorage-dependent regulation of ERK2 activation

  Masaru Mitsushima; Kazumitsu Ueda; Noriyuki Kioka

  EXPERIMENTAL CELL RESEARCH, May 2007, Peer-reviewed

  
• Modulation of drug-stimulated ATPase activity of human MDR1/P-glycoprotein by cholesterol

  Yasuhisa Kimura; Noriyuki Kioka; Hiroaki Kato; Michinori Matsuo; Kazumitsu Ueda

  BIOCHEMICAL JOURNAL, Jan. 2007, Peer-reviewed

  
• Bile salt-dependent efflux of cellular phospholipids mediated by ATP binding cassette protein B4

  Morita, S.-Y.; Kobayashi, A.; Takanezawa, Y.; Kioka, N.; Handa, T.; Arai, H.; Matsuo, M.; Ueda, K.

  Hepatology, 2007, Peer-reviewed

  
• Vinexin beta regulates the phosphorylation of epidermal growth factor receptor on the cell surface

  Masaru Mitsushima; Kazumitsu Ueda; Noriyuki Kioka

  GENES TO CELLS, Sep. 2006, Peer-reviewed

  
• Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1

  Aya Kobayashi; Yasukazu Takanezawa; Takashi Hirata; Yuji Shimizu; Keiko Misasa; Noriyuki Kioka; Hiroyuki Arai; Kazumitsu Ueda; Michinori Matsuo

  JOURNAL OF LIPID RESEARCH, Aug. 2006, Peer-reviewed

  
• Abl kinase interacts with and phosphorylates vinexin

  Masaru Mitsushima; Honami Takahashi; Tomoyuki Shishido; Kazumitsu Ueda; Noriyuki Kioka

  FEBS LETTERS, Jul. 2006, Peer-reviewed

  
• Purification and ATPase activity of human ABCA1

  K Takahashi; Y Kimura; N Kioka; M Matsuo; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2006, Peer-reviewed

  
• Protein kinase A-dependent increase in WAVE2 expression induced by the focal adhesion protein vinexin

  M Mitsushima; T Sezaki; R Akahane; K Ueda; S Suetsugu; T Takenawa; N Kioka

  GENES TO CELLS, Mar. 2006, Peer-reviewed

  
• SHIP2 interaction with the cytoskeletal protein Vinexin

  N Paternotte; J Zhang; Vandenbroere, I; K Backers; D Blero; N Kioka; JM Vanderwinden; Pirson, I; C Erneux

  FEBS JOURNAL, Dec. 2005, Peer-reviewed

  
• Detection of ABCA7-positive cells in salivary glands from patients with Sjogren's syndrome

  Y Toda; R Aoki; Y Ikeda; Y Azuma; N Kioka; M Matsuo; M Sakamoto; S Mori; M Fukumoto; K Ueda

  PATHOLOGY INTERNATIONAL, Oct. 2005, Peer-reviewed

  
• Role of interaction with vinculin in recruitment of vinexins to focal adhesions

  H Takahashi; M Mitsushima; N Okada; T Ito; S Aizawa; R Akahane; T Umemoto; K Ueda; N Kioka

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Oct. 2005, Peer-reviewed

  
• Spatial distribution and functional significance of activated vinculin in living cells

  H Chen; DM Cohen; DM Choudhury; N Kioka; SW Craig

  JOURNAL OF CELL BIOLOGY, May 2005, Peer-reviewed

  
• Human ABCA3, a product of a responsible gene fair abca3 for fatal surfactant deficiency in newborns, exhibit unique ATP hydrolysis activity and generates intracellular multilamellar vesicles

  K Nagata; A Yamamoto; N Ban; AR Tanaka; M Matsuo; N Kioka; N Inagaki; K Ueda

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2004, Peer-reviewed

  
• Extracellular signal-regulated kinase activated by epidermal growth factor and cell adhesion interacts with and phosphorylates vinexin

  M Mitsushima; A Suwa; T Amachi; K Ueda; N Kioka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2004, Peer-reviewed

  
• alpha 1-syntrophin modulates turnover of ABCA1

  Y Munehira; T Ohnishi; S Kawamoto; A Furuya; K Shitara; M Imamura; T Yokota; S Takeda; T Amachi; M Matsuo; N Kioka; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2004, Peer-reviewed

  
• ATP hydrolysis-dependent multidrug efflux transporter: MDRI/P-glycoprotein

  Y Kimura; M Matsuo; K Takahashi; T Saeki; N Kioka; T Amachi; K Ueda

  CURRENT DRUG METABOLISM, Feb. 2004, Peer-reviewed

  
• Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release

  Y Ikeda; S Abe-Dohmae; Y Munehira; R Aoki; S Kawamoto; A Furuya; K Shitara; T Amachi; N Kioka; M Matsuo; S Yokoyama; K Ueda

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Nov. 2003, Peer-reviewed

  
• Genomic structure and 5 '-flanking sequences of rat N-acetylglucosaminyltransferase I gene and regulatory role of its transcriptional diversity

  T Fukada; M Ono; S Sakata; N Kioka; H Sakai; T Komano

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jul. 2003, Peer-reviewed

  
• Interaction of lp-dlg/KIAA0583, a membrane-associated guanylate kinase family protein, with vinexin and beta-catenin at sites of cell-cell contact

  M Wakabayashi; T Ito; M Mitsushima; S Aizawa; K Ueda; T Amachi; N Kioka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2003, Peer-reviewed

  
• SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor

  SM Townson; KM Dobrzycka; AV Lee; M Air; WL Deng; KY Kang; SM Jiang; N Kioka; K Michaelis; S Oesterreich

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2003, Peer-reviewed

  
• SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor

  SM Townson; KM Dobrzycka; AV Lee; M Air; WL Deng; KY Kang; SM Jiang; N Kioka; K Michaelis; S Oesterreich

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2003, Peer-reviewed

  
• Erratum: Effects of mutations of ABCA1 in the first extracellular domain on subcellular trafficking and ATP binding/hydrolysis (The Journal of Biological Chemistry (2003) 278 (8815-8819))

  Tanaka, A.R.; Abe-Dohmae, S.; Ohnishi, T.; Aoki, R.; Morinaga, G.; Okuhira, K.-I.; Ikeda, Y.; Kano, F.; Matsuo, M.; Kioka, N.; Amachi, T.; Murata, M.; Yokoyama, S.; Ueda, K.

  Journal of Biological Chemistry, 18 Apr. 2003

  
• Effects of mutations of ABCA1 in the first extracellular domain on subcellular trafficking and ATP binding/hydrolysis

  AR Tanaka; S Abe-Dohmae; T Ohnishi; R Aoki; G Morinaga; K Okuhira; Y Ikeda; F Kano; M Matsuo; N Kioka; T Amachi; M Murata; S Yokoyama; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2003, Peer-reviewed

  
• Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/]Luc7A

  H Umehara; Y Nishii; M Morishima; Y Kakehi; N Kioka; T Amachi; J Koizumi; M Hagiwara; K Ueda

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2003, Peer-reviewed

  
• A novel focal adhesion protein involved in the anchorage dependence of growth factor signaling

  Noriyuki Kioka

  Nippon Nogeikagaku Kaishi, 2003, Peer-reviewed

  
• A novel focal adhesion protein involved in the anchorage dependence of growth factor signaling

  N Kioka

  NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY, 2003, Peer-reviewed

  
• 細胞接着・細胞骨格とシグナル伝達を制御する新しいタンパク質ファミリー : ビネキシン, CAP/ポンシン, ArgBP2

  木岡 紀幸

  生化學, 25 Nov. 2002, Peer-reviewed

  
• A novel adaptor protein family regulating cytoskeletal organization and signal transduction - Vinexin, CAP/ponsin, ArgBP2

  N Kioka

  SEIKAGAKU, Nov. 2002, Peer-reviewed

  
• ATP binding/hydrolysis by and phosphorylation of peroxisomal ATP-binding cassette proteins PMP70 (ABCD3) and adrenoleukodystrophy protein (ABCD1)

  AR Tanaka; K Tanabe; M Morita; M Kurisu; Y Kasiwayama; M Matsuo; N Kioka; T Amachi; T Imanaka; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2002, Peer-reviewed

  
• Vinexin beta regulates the anchorage dependence of ERK2 activation stimulated by epidermal growth factor

  A Suwa; M Mitsushima; T Ito; M Akamatsu; K Ueda; T Amachi; N Kioka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2002, Peer-reviewed

  
• Vinexin, CAP/ponsin, ArgBP2: a novel adaptor protein family regulating cytoskeletal organization and signal transduction

  N Kioka; K Ueda; T Amachi

  CELL STRUCTURE AND FUNCTION, Feb. 2002, Peer-reviewed

  
• 細胞膜裏打ちタンパク質による細胞接着／細胞骨格とシグナル伝達の制御

  木岡 紀幸

  実験医学,20(2) 237, 2002, Peer-reviewed

  
• Expression of vinexin alpha in the dorsal half of the eye and in the cardiac outflow tract and atrioventricular canal

  T Kawauchi; M Ikeya; S Takada; K Ueda; M Shirai; Y Takihara; N Kioka; T Amachi

  MECHANISMS OF DEVELOPMENT, Aug. 2001, Peer-reviewed

  
• Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjogren's syndrome

  AR Tanaka; Y Ikeda; S Abe-Dohmae; R Arakawa; K Sadanami; A Kidera; S Nakagawa; T Nagase; R Aoki; N Kioka; T Amachi; S Yokoyama; K Ueda

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2001, Peer-reviewed

  
• Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjögren's syndrome

  Arowu R. Tanaka; Yuika Ikeda; Sumiko Abe-Dohmae; Reijiro Arakawa; Keishi Sadanami; Akinori Kidera; Satoshi Nakagawa; Takahiro Nagase; Ryo Aoki; Noriyuki Kioka; Teruo Amachi; Shinji Yokoyama; Kazumitsu Ueda

  Biochemical and Biophysical Research Communications, 2001, Peer-reviewed

  
• Functional analysis of a mutant sulfonylurea receptor, SUR1-R1420C, that is responsible for persistent hyperinsulinemic hypoglycemia of infancy

  M Matsuo; S Trapp; Y Tanizawa; N Kioka; T Amachi; Y Oka; FM Ashcroft; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2000, Peer-reviewed

  
• Different binding properties and affinities for ATP and ADP among sulfonylurea receptor subtypes, SUR1, SUR2A, and SUR2B

  M Matsuo; K Tanabe; N Kioka; T Amachi; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2000, Peer-reviewed

  
• Nonequivalent nucleotide trapping in the two nucleotide binding folds of the human multidrug resistance protein MRP1

  K Nagata; M Nishitani; M Matsuo; N Kioka; T Amachi; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2000, Peer-reviewed

  
• Direct photoaffinity labeling of Kir6.2 by [gamma-P-32]ATP-[gamma]4-azidoanilide

  K Tanabe; SJ Tucker; FM Ashcroft; P Proks; N Kioka; T Amachi; K Ueda

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2000, Peer-reviewed

  
• CROP/Luc7A, a novel serine/arginine-rich nuclear protein, isolated from cisplatin-resistant cell line

  Y Nishii; M Morishima; Y Kakehi; K Umehara; N Kioka; Y Terano; T Amachi; K Ueda

  FEBS LETTERS, Jan. 2000, Peer-reviewed

  
• ATP binding properties of the nucleotide-binding folds of SUR1

  M Matsuo; N Kioka; T Amachi; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1999, Peer-reviewed

  
• Vinexin forms a signaling complex with Sos and modulates epidermal growth factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activities

  M Akamatsu; S Aota; A Suwa; K Ueda; T Amachi; KM Yamada; SK Akiyama; N Kioka

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1999, Peer-reviewed

  
• Comparative aspects of the function and mechanism of SUR1 and MDR1 proteins

  Ueda, K.; Matsuo, M.; Tanabe, K.; Morita, K.; Kioka, N.; Amachi, T.

  Biochimica et Biophysica Acta - Biomembranes, Dec. 1999, Peer-reviewed

  
• A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors

  Nishikimi, A.; Mukai, J.; Kioka, N.; Yamada, M.

  Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology, Nov. 1999, Peer-reviewed

  
• A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors

  A Nishikimi; J Mukai; N Kioka; M Yamada

  BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, Nov. 1999, Peer-reviewed

  
• Structure and transcription of the gene coding for polypeptide chain elongation factor 1 alpha of medaka Oryzias latipes

  M Kinoshita; T Nakata; T Yabe; K Adachi; Y Yokoyama; T Hirata; E Takayama; S Mikawa; N Kioka; M Takahashi; H Toyohara; M Sakaguchi

  FISHERIES SCIENCE, Oct. 1999, Peer-reviewed

  
• cDNA cloning of polypeptide chain elongation factor 1 alpha from medaka Oryzias latipes

  M Kinoshita; T Nakata; K Adachi; T Yabe; Y Yokoyama; H Toyohara; T Hirata; E Takayama; S Mikawa; N Kioka; M Sakaguchi

  FISHERIES SCIENCE, Feb. 1999, Peer-reviewed

  
• Vinexin: A novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization

  N Kioka; S Sakata; T Kawauchi; T Amachi; SK Akiyama; K Okazaki; C Yaen; KM Yamada; S Aota

  JOURNAL OF CELL BIOLOGY, Jan. 1999, Peer-reviewed

  
• Expression and characterization of rat UDP-N-acetylglucosamine: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I in Saccharomyces cerevisiae

  S Yoshida; M Suzuki; S Yamano; M Takeuchi; H Ikenaga; N Kioka; H Sakai; T Komano

  GLYCOBIOLOGY, Jan. 1999, Peer-reviewed

  
• Expression and characterization of rat UDP-N-acetylglucosamine: alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I in Saccharomyces cerevisiae

  S Yoshida; M Suzuki; S Yamano; M Takeuchi; H Ikenaga; N Kioka; H Sakai; T Komano

  GLYCOBIOLOGY, Jan. 1999, Peer-reviewed

  
• Vinexin: A novel vinculin-binding protein with multiple SH3 domains enhances actin cytoskeletal organization

  N Kioka; S Sakata; T Kawauchi; T Amachi; SK Akiyama; K Okazaki; C Yaen; KM Yamada; S Aota

  JOURNAL OF CELL BIOLOGY, Jan. 1999, Peer-reviewed

  
• Different response to inflammation of the multiple mRNAs of rat N-acetylglucosaminyltransferase I with variable 5 '-untranslated sequences

  T Fukada; N Kioka; J Nishiu; S Sakata; H Sakai; M Yamada; T Komano

  FEBS LETTERS, Oct. 1998, Peer-reviewed

  
• 細胞骨格を利用した病原性細菌の巧妙な細胞内，細胞間移動の戦略

  木岡紀幸

  生物工学会誌, Jun. 1998, Peer-reviewed

  
• CHARACTERIZATION OF RAT N-ACETYLGLUCOSAMINYLTRANSFERASE-I EXPRESSED IN ESCHERICHIA-COLI

  J NISHIU; N KIOKA; T FUKADA; H SAKAI; T KOMANO

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Sep. 1995, Peer-reviewed

  
• ZINC-INDUCED ACTIVATION OF RAINBOW-TROUT METALLOTHIONEIN-A PROMOTER IN TRANSGENIC MEDAKA

  M KINOSHITA; H TOYOHARA; M SAKAGUCHI; N KIOKA; T KOMANO; K INOUE; S YAMASHITA; M SATAKE; Y WAKAMATSU; K OZATO

  FISHERIES SCIENCE, Jun. 1994, Peer-reviewed

  
• CLONING OF A CDNA-ENCODING N-ACETYLGLUCOSAMINYLTRANSFERASE-I FROM RAT-LIVER AND ANALYSIS OF ITS EXPRESSION IN RAT-TISSUES

  T FUKADA; K IIDA; N KIOKA; H SAKAI; T KOMANO

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jan. 1994, Peer-reviewed

  
• Cloning of a cDNA Encoding yV-Acetylglucosaminyltransferase I from Rat Liver and Analysis of Its Expression in Rat Tissues

  Takashi Fukada; Kenji Iida; Noriyuki Kioka; Hiroshi Sakai; Tohru Komano

  Bioscience, Biotechnology, and Biochemistry, 1994, Peer-reviewed

  
• 糖転移酵素遺伝子の解析

  木岡 紀幸

  化学,48/6,428, 1993, Peer-reviewed

  
• HUMAN P-GLYCOPROTEIN TRANSPORTS CORTISOL, ALDOSTERONE, AND DEXAMETHASONE, BUT NOT PROGESTERONE

  K UEDA; N OKAMURA; M HIRAI; Y TANIGAWARA; T SAEKI; N KIOKA; T KOMANO; R HORI

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 1992, Peer-reviewed

  
• TRANSPORT OF DIGOXIN BY HUMAN P-GLYCOPROTEIN EXPRESSED IN A PORCINE KIDNEY EPITHELIAL-CELL LINE (LLC-PK1)

  Y TANIGAWARA; N OKAMURA; M HIRAI; M YASUHARA; K UEDA; N KIOKA; T KOMANO; R HORI

  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Nov. 1992, Peer-reviewed

  
• QUERCETIN, A BIOFLAVONOID, INHIBITS THE INCREASE OF HUMAN MULTIDRUG RESISTANCE GENE (MDR1) EXPRESSION CAUSED BY ARSENITE

  N KIOKA; N HOSOKAWA; T KOMANO; K HIRAYOSHI; K NAGATA; K UEDA

  FEBS LETTERS, Apr. 1992, Peer-reviewed

  
• HEAT-SHOCK RESPONSIVE ELEMENTS IN THE INDUCTION OF THE MULTIDRUG RESISTANCE GENE (MDR1)

  N KIOKA; Y YAMANO; T KOMANO; K UEDA

  FEBS LETTERS, Apr. 1992, Peer-reviewed

  
• STRUCTURAL-ANALYSIS OF REPETITIVE DNA-SEQUENCES IN THE GOAT GROWTH-HORMONE GENE REGION

  Y YAMANO; M ABE; S MIKAWA; N KIOKA; E MANABE; H SAKAI; T KOMANO; K UTSUMI; A IRITANI

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY, Mar. 1991, Peer-reviewed

  
• 多剤耐性の分子機構

  木岡 紀幸

  腫瘍と感染,3/6,443, 1990, Peer-reviewed

  
• DETECTION OF MULTIDRUG RESISTANCE (MDR1) GENE RNA EXPRESSION IN HUMAN-TUMORS BY A SENSITIVE RIBONUCLEASE PROTECTION ASSAY

  K UEDA; Y YAMANO; N KIOKA; Y KAKEHI; O YOSHIDA; MM GOTTESMAN; PASTAN, I; T KOMANO

  JAPANESE JOURNAL OF CANCER RESEARCH, Nov. 1989, Peer-reviewed

  
• P-GLYCOPROTEIN GENE (MDR1) CDNA FROM HUMAN ADRENAL - NORMAL P-GLYCOPROTEIN CARRIES GLY185 WITH AN ALTERED PATTERN OF MULTIDRUG RESISTANCE

  N KIOKA; J TSUBOTA; Y KAKEHI; T KOMANO; MM GOTTESMAN; PASTAN, I; K UEDA

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jul. 1989, Peer-reviewed

  
• CLONING AND SEQUENCING OF GOAT GROWTH-HORMONE GENE

  N KIOKA; E MANABE; M ABE; H HASHI; M YATO; M OKUNO; Y YAMANO; H SAKAI; T KOMANO; K UTSUMI; A IRITANI

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY, Jun. 1989, Peer-reviewed

  
• A RUNAWAY-REPLICATION PLASMID PSY343 CONTAINS 2 SSI SIGNALS

  JD BAHK; N KIOKA; H SAKAI; T KOMANO

  PLASMID, Nov. 1988, Peer-reviewed

  
• NUCLEOTIDE-SEQUENCE OF THE GROWTH-HORMONE GENE CDNA FROM GOAT CAPRA-HIRCUS L (TOKARA)

  M YATO; Y YAMANO; K OYABAYASHI; M OKUNO; N KIOKA; E MANABE; H HASHI; H SAKAI; T KOMANO; K UTSUMI; A IRITANI

  NUCLEIC ACIDS RESEARCH, Apr. 1988, Peer-reviewed

  
• CLONING AND SEQUENCING OF CDNA THAT ENCODES GOAT GROWTH-HORMONE

  Y YAMANO; K OYABAYASHI; M OKUNO; M YATO; N KIOKA; E MANABE; H HASHI; H SAKAI; T KOMANO; K UTSUMI; A IRITANI

  FEBS LETTERS, Feb. 1988, Peer-reviewed

  

Misc.

• DEAD-box型RNAヘリカーゼUAP56およびURH49による遺伝子発現制御を介した染色体分配機構における異なる役割

  山崎 智弘; 藤原 奈央子; 栗原 朋也; 幸長 弘子; 戎家 美紀; 西田 栄介; 木岡 紀幸; 神戸 大朋; 永尾 雅哉; 増田 誠司

  日本生化学会大会プログラム・講演要旨集, Sep. 2009

  
• HPLCによる薬物トランスポーターMDR1の新規ATP加水分解活性測定法

  木村泰久; 芝崎誠司; 森里恵; 松尾道憲; 木岡紀幸; 天知輝夫; 植田充美; 植田和光

  日本分子生物学会年会プログラム・講演要旨集, 2003

  
• 接着斑細胞膜脂質の単離と解析

  箕浦広大; 市川尚文; 大町朋弘; 真鍋祐樹; 菅原達也; 植田和光; 植田和光; 木岡紀幸

  脂質生化学研究, 2017

  
• 細胞-ECM間接着領域における細胞膜脂質組成の解析

  箕浦広大; 市川尚文; 大町朋弘; 植田和光; 植田和光; 木岡紀幸

  日本生化学会大会(Web), 2017

  
• 細胞の「力比べ」アッセイ

  福田翔太; 松井翼; 市川尚文; 古川太一; 木岡紀幸; 福島修一郎; 出口真次

  HAB研究機構学術年会プログラム・要旨集, 2017

  
• 細胞収縮力発生におけるビネキシンファミリータンパク質の役割

  市川尚文; 松井翼; 松井翼; 荒木智彦; 喜多真弘; 植田和光; 植田和光; 出口真次; 出口真次; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2017

  
• ビネキシンαの両親媒性ヘリックスはビンキュリンの頭部と相互作用する

  日野直也; 市川尚文; 木村泰久; 植田和光; 植田和光; 木岡紀幸

  日本細胞生物学会大会要旨集, 2015

  
• ビネキシンファミリータンパク質の接着斑を介したメカノセンシング機能の比較解析

  市川尚文; 喜多真弘; 木村泰久; 植田和光; 植田和光; 木岡紀幸

  日本細胞生物学会大会要旨集, 2015

  
• ビネキシン-ビンキュリン相互作用の生化学的解析

  市川尚文; 山下寛; 松山大輔; 植田和光; 植田和光; 木岡紀幸

  日本農芸化学会大会講演要旨集, 2011

  
• マウス1細胞期はいにおいて細胞周期のG₂期への進行にしたがって核内に蓄積される新規100-kDaタンパクcDNAのクローニング

  錦見昭彦; 向井二郎; 木岡紀幸; 今井裕; 山田雅保

  日本畜産学会大会講演要旨, 1999

  
• Interaction of the third SH3 domain of cytoskeltal protein vinexin with guanine nucleotide exchange factor Sos

  AKAMATSU Masahiko; AOTA Shinichi; SAKATA Shouhei; AMACHI Teruo; K. AKIYAMA Steven; KIOKA Noriyuki

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• NF-κBの核移行シグナルを標的として作製した抗ペプチド抗体により認識されるタンパク質のマウスはいにおける細胞内局在

  綿見昭彦; 向井二郎; 木岡紀幸; 今井裕; 山田雅保

  日本繁殖生物学会講演要旨, 1998

  
• Molecular basis for sencing the stiffness of extracellular matrix through focal adhesion proteins

  木岡 紀幸

  旭硝子財団助成研究成果報告, 2013

  
• 細胞接着/細胞骨格とシグナル伝達を制御する蛋白質 SH3(Src homology 3)領域を3つもつ新しい遺伝子ファミリービネキシン, CAP/ポンシン, ArgBP2

  木岡 紀幸

  化学と生物, 25 Dec. 1999

  
• A system for transient localization of lipid-modifying enzyme to focal adhesion using chemically induced dimerization

  増元亮裕; 木村泰久; 木岡紀幸

  日本細胞生物学会大会(Web), 2021

  
• FA membrane has a specific lipid composition

  立花大; 長尾耕治郎; 木村泰久; 木岡紀幸

  日本細胞生物学会大会(Web), 2021

  
• Purification of Focal Adhesion Protein, Vinexin α using Mammalian Cells

  鎌田一希; 木村泰久; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2021

  
• C-terminus of ABCA1 separately regulates cholesterol-flopping activity and HDL-generating activity

  小笠原史彦; 岡本雄介; 木村泰久; 木岡紀幸; 木岡紀幸; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2021

  
• A system for transient PIP5K localization to focal adhesion using chemically induced dimerization

  増元亮裕; 木村泰久; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2021

  
• Expression and purification of a lipid efflux ABC protein aiming for Cryo-EM analysis

  小段篤史; 光岡薫; 木村泰久; 木岡紀幸; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2021

  
• SORBS family proteins regulate meflin expression

  高橋真助; 柴原正和; 榎本篤; 木村泰久; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2021

  
• Thermodynamic analysis of the enhancement of substrate-dependent ATPase activity of MDR1 by cholesterol.

  岩村紗花; 木岡紀幸; 植田和光; 木村泰久

  日本農芸化学会大会講演要旨集(Web), 2021

  
• The identification of new focal adhesion proteins that are related with mechanosensing

  田辺修平; 柴原正和; 立花大; 木村泰久; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2021

  
• The effect of collagen peptide on proliferation and migration of cancer cells

  倉田淳代; 木村泰久; 松尾道憲; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2021

  
• The analysis of the sterol specificity of human ABCA1 using liposomes

  坂田和樹; 木岡紀幸; 植田和光; 木村泰久

  日本農芸化学会大会講演要旨集(Web), 2021

  
• Comparative analysis of the lipid composition of focal adhesion membrane and plasma membrane

  立花大; 箕浦広大; 長尾耕治郎; 木村泰久; 植田和光; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2021

  
• ヒトABCA1の活性誘導とステロール構造の関連解析

  坂田和樹; 木岡紀幸; 植田和光; 木村泰久

  脂質生化学研究, 2021

  
• The effect of collagen peptide on cancer cell

  倉田淳代; 木村泰久; 松尾道憲; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2020

  
• コレステロールによるMDR1の活性誘導とrhodamine化合物の構造関連性

  岩村紗花; 木岡紀幸; 植田和光; 木村泰久

  日本生化学会大会(Web), 2020

  
• ABCA1のHDL産生活性およびコレステロールフロップ活性の調節

  岡本雄介; 小笠原史彦; 木村泰久; 木岡紀幸; 木岡紀幸; 植田和光

  脂質生化学研究, 2020

  
• HPLC-ELSDによるABCA1,ABCB4の脂質排出活性測定

  高橋智; 北悠人; 木岡紀幸; 木岡紀幸; 植田和光; 木村泰久

  トランスポーター研究会年会抄録集, 2020

  
• 接着斑タンパク質ビネキシンαは相分離に関与するか?

  鎌田一希; 木村泰久; 木岡紀幸

  日本生化学会大会(Web), 2020

  
• コレステロール輸送体ABCA1の生理的役割のメダカを用いた解析

  二股良太; 木下政人; 木村泰久; 木岡紀幸; 木岡紀幸; 植田和光

  脂質生化学研究, 2020

  
• 巨大リポソーム(GUV)を用いたヒトABCA1の新規機能解析手法の開発

  坂田和樹; 木岡紀幸; 植田和光; 木村泰久

  脂質生化学研究, 2020

  
• 光誘導性二量体化及び化学誘導性二量体化を用いた接着斑へのタンパク質の一過的局在化システム

  増元亮裕; 木村泰久; 木岡紀幸

  日本生化学会大会(Web), 2020

  
• 巨大リポソーム(GUV)を用いたヒトABCA1の再構成系の開発

  坂田和樹; 木岡紀幸; 植田和光; 木村泰久

  日本生化学会大会(Web), 2020

  
• Establishment of an in vitro reconstitution system for nascent HDL formation.

  坂田和樹; 木岡紀幸; 植田和光; 木村泰久

  日本農芸化学会大会講演要旨集(Web), 2020

  
• The Effect of Cholesterol on Substrate Transport of MDR1

  岩村紗花; 木岡紀幸; 植田和光; 木村泰久

  日本農芸化学会大会講演要旨集(Web), 2020

  
• Isolation and analysis of proteins localized to focal adhesions depending on Vinexin α / CAP

  柴原正和; 阿部雄一; 木村泰久; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2020

  
• 硬さ感知・応答に関与する新規接着斑タンパク質の探索を目指したプロテオーム解析

  柴原正和; 立花大; 阿部雄一; 木村泰久; 植田和光; 木岡紀幸

  日本分子生物学会年会プログラム・要旨集(Web), 2020

  
• ABCA1とABCB4はアシル鎖非特異的にホスファチジルコリンを排出する

  高橋智; 木岡紀幸; 木岡紀幸; 植田和光; 木村泰久

  日本分子生物学会年会プログラム・要旨集(Web), 2020

  
• ビネキシンファミリータンパク質が間葉系幹細胞の分化を調節する分子基盤の解明

  高橋真助; 黒田美都; 阿部雄一; 木村泰久; 木岡紀幸

  日本農芸化学会関西支部講演会講演要旨集, 2019

  
• ELSD法を用いたヒトABCタンパク質の脂質輸送能解析手法の構築

  高橋智; 北悠人; 木岡紀幸; 植田和光; 植田和光; 木村泰久

  日本農芸化学会大会講演要旨集(Web), 2019

  
• ApoA-Iを封入した巨大リポソーム(GUV)の作製

  坂田和樹; 木岡紀幸; 植田和光; 植田和光; 木村泰久

  日本農芸化学会大会講演要旨集(Web), 2019

  
• ヒト多剤輸送体 P-糖タンパク質の酵素活性にコレステロールが与える影響の解析

  岩村紗花; 木岡紀幸; 植田和光; 木村泰久

  日本農芸化学会関西支部講演会講演要旨集, 2019

  
• 極性脂質に含まれるヒトABCG4の輸送基質探索および認識機構の解析

  末永光; 見月俊吾; 木岡紀幸; 植田和光; 植田和光; 木村泰久

  日本農芸化学会大会講演要旨集(Web), 2019

  
• 細胞膜コレステロール濃度の上昇に依存したABCA1によるHDL産生速度の増加

  小笠原史彦; 木村泰久; 木岡紀幸; 木岡紀幸; 植田和光

  脂質生化学研究, 2019

  
• リン脂質輸送体ABCB4の第4膜貫通ヘリックスに存在するプロリンの機能解析

  小川峻; 末永健人; 木岡紀幸; 植田和光; 植田和光; 木村泰久

  日本農芸化学会大会講演要旨集(Web), 2019

  
• 多剤輸送体P-glycoprotein(ABCB1)による薬剤輸送には2分子のATP結合・加水分解が共役する

  二股良太; 小笠原史彦; 市川尚文; 木村泰久; 木岡紀幸; 木岡紀幸; 植田和光; 植田和光

  日本生化学会大会(Web), 2019

  
• 接着斑細胞膜の単離手法の確立とビンキュリンの接着斑細胞膜への影響

  立花大; 柴原正和; 大町朋弘; 箕浦広大; 木村泰久; 植田和光; 木岡紀幸

  日本分子生物学会年会プログラム・要旨集(Web), 2019

  
• HPLC-ELSDによるヒトABCタンパク質の脂質排出活性測定手法の確立

  高橋智; 北悠人; 木岡紀幸; 植田和光; 木村泰久

  日本農芸化学会関西支部講演会講演要旨集, 2019

  
• ABCA1によるコレステロール輸送の生理的重要性

  小笠原史彦; 木村泰久; 木岡紀幸; 木岡紀幸; 植田和光

  日本生化学会大会(Web), 2019

  
• コレステロール結合性細菌毒素ストレプトリジンOを用いたABCA1によるコレステロール輸送の証明

  小笠原史彦; 木村泰久; 木岡紀幸; 植田和光; 植田和光

  脂質生化学研究, 2018

  
• ヒト由来浮遊培養細胞への遺伝子導入手法の検討

  木村泰久; 松尾道憲; 木岡紀幸; 植田和光; 植田和光

  日本農芸化学会関西支部講演会講演要旨集, 2018

  
• 生細胞膜上でヒト多剤輸送体MDR1(ABCB1)の構造変化の際にATPが果たす役割の解明

  二股良太; 小笠原史彦; 市川尚文; 木村泰久; 木岡紀幸; 植田和光; 植田和光

  日本生化学会大会(Web), 2018

  
• ABCG4が輸送する極性脂質中の未知基質の探索

  末永光; 見月俊吾; 木岡紀幸; 植田和光; 植田和光; 木村泰久

  日本生化学会大会(Web), 2018

  
• ABCAサブファミリータンパク質のC末端領域の機能解明を目的としたキメラタンパク質の解析

  岡本雄介; 永田紅; 笠井倫志; 木村泰久; 木岡紀幸; 木岡紀幸; 植田和光; 植田和光

  日本生化学会大会(Web), 2018

  
• ヒト多剤輸送体(MDR1)の輸送基質取り込み機構の解析

  木村泰久; 井上修一; 末永健人; 木岡紀幸; 植田和光; 植田和光

  日本生化学会大会(Web), 2018

  
• 超音波処理を用いた接着斑の単離

  柴原正和; 箕浦広大; 市川尚文; 木村泰久; 木村泰久; 植田和光; 植田和光; 木岡紀幸; 木岡紀幸

  日本生化学会大会(Web), 2018

  
• ATP加水分解活性を指標としたヒトABCG4の輸送基質特異性解析

  末永光; 見月俊吾; 木岡紀幸; 植田和光; 木村泰久

  トランスポーター研究会年会抄録集, 2018

  
• ABCA1とapoA-Iによるコレステロール排出メカニズム解明への新しい定量的アプローチ

  三好里奈; 小笠原史彦; 石神正人; 永田紅; 永田紅; 木村泰久; 木岡紀幸; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2017

  
• ビネキシンのホスファチジン酸結合領域の解析

  伊藤有亮; 市川尚文; 折田雄一郎; 安部真人; 木村泰久; 植田和光; 植田和光; 三芳秀人; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2017

  
• コレステロール認識配列CRACは,ヒトABCG4のコレステロール輸送において重要である

  見月俊吾; 木村泰久; 木岡紀幸; 松尾道憲; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2017

  
• 細胞-ECM間接着領域の細胞膜は脂質ラフト様の脂質組成を有する

  箕浦広大; 市川尚文; 木村泰久; 植田和光; 植田和光; 木岡紀幸

  日本農芸化学会中四国支部講演会講演要旨集(Web), 2017

  
• ビネキシンαの両親媒性ヘリックスはビンキュリンの構造変化に必要である

  日野直也; 市川尚文; 木村泰久; 植田和光; 植田和光; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2017

  
• 間葉系幹細胞分化のレチノイン酸制御に与える接着斑タンパク質ビネキシンの影響

  高田恭子; 黒田美都; 黒田美都; 木村泰久; 植田和光; 植田和光; 木岡紀幸; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2017

  
• ヒトABCB6に存在する機能未知膜ドメイン(TMD0)の解析

  西澤奈美; 木村泰久; 大貫元; 木岡紀幸; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2016

  
• キノコ由来新規化合物がNPC1L1依存性コレステロール取込みに及ぼす影響

  千場智尋; 千場智尋; 櫻田剛史; 渡邊理恵; 山口宏二; 木村泰久; 木岡紀幸; 河岸洋和; 河岸洋和; 松尾道憲; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2016

  
• ビネキシンαとホスファチジン酸の相互作用解析

  伊藤有亮; 市川尚文; 木村泰久; 植田和光; 植田和光; 木岡紀幸

  日本農芸化学会大会講演要旨集(Web), 2016

  
• ヒトABCG4に存在するコレステロール認識配列の機能解析

  見月俊吾; 木村泰久; 木岡紀幸; 松尾道憲; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2016

  
• ビネキシンαの両親媒性ヘリックスはテーリンと協調的にビンキュリンと相互作用する

  日野直也; 市川尚文; 木村泰久; 植田和光; 植田和光; 木岡紀幸

  日本細胞生物学会大会(Web), 2016

  
• HDL産生の鍵を握るABCA1のC末端領域の機能解析

  岡本雄介; 永田紅; 笠井倫志; 楠見明弘; 楠見明弘; 木村泰久; 木岡紀幸; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2016

  
• 原子間力顕微鏡(AFM)観察に向けたABCタンパク質サンプルの最適化

  山原一晃; 木村泰久; 柴田幹大; 内橋貴之; 内橋貴之; 安藤敏夫; 安藤敏夫; 木岡紀幸; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2016

  
• ヒトABCA1の細胞外ドメインに対するモノクローナル抗体の作製とエピトープ探索

  三好里奈; 富岡麻衣子; 小笠原史彦; 木村泰久; 木岡紀幸; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2016

  
• ABCA1細胞外ドメインのHDL産生における役割の解析

  小笠原史彦; 石神正登; 木村泰久; 木岡紀幸; 植田和光; 植田和光

  日本農芸化学会大会講演要旨集(Web), 2016

  
• HDL産生におけるABCA1細胞外ドメインの脂質蓄積機能

  小笠原史彦; 石神正登; 木村泰久; 木岡紀幸; 植田和光; 植田和光

  日本生化学会大会(Web), 2015

  
• 接着斑タンパク質ビネキシンαの両親媒性ヘリックスはビンキュリンの構造変化を引き起こすために必要である

  日野直也; 市川尚文; 木村泰久; 植田和光; 植田和光; 木岡紀幸

  日本生化学会大会(Web), 2015

  
• ビンキュリンの細胞外マトリクスの硬さ感知にはアクチン繊維結合が必要である

  大町朋弘; 市川尚文; 木村泰久; 植田和光; 植田和光; 木岡紀幸

  日本生化学会大会(Web), 2015

  
• ABCG4のTM6に存在するCRAC domainの機能解析

  見月俊吾; 木村泰久; 木岡紀幸; 松尾道憲; 植田和光; 植田和光

  日本生化学会大会(Web), 2015

  
• Mechanosensor at Cell-Extracellular matrix adhesion sites

  Noriyuki Kioka

  生体の科学, 15 Aug. 2019, Invited, Lead author, Last author, Corresponding author

  
• 細胞収縮力アッセイ

  出口 真次; 松井 翼; 市川 尚文; 木岡 紀幸

  月刊「細胞」, 2019

  
• 細胞収縮力のアッセイ − メカノバイオロジー研究のツール

  出口 真次; 松井 翼; 市川 尚文; 木岡 紀幸

  Precision Medicine, Oct. 2018

  
• Analysis of the substrates entry gate mechanism of human MDR1

  Kento Suenaga; Syuichi Inoue; Yasuhisa Kimura; Noriyuki Kioka; Hiraoki Kato; Kaztumitsu Ueda

  日本農芸化学会2015年度大会, 2015

  
• Mechanosensor for sensing stiffness of extracellular matrix

  Noriyuki Kioka

  日本農芸化学会2016年度大会, 2015

  
• Identification of a novel natural product fomiroid A, which inhibits NPC1L1-dependent cholesterol uptake, from the mushroom Fomitopsis nigra.

  Tomohiro CHIBA; Tsuyoshi SAKURADA; Rie WATANABE; Kohji YAMAGUCHI; Yasuhisa KIMURA; Noriyuki KIOKA; Hirokazu KAWAGISHI; Michinori MATSUO; Kazumitsu UEDA

  日本農芸化学会2015年度大会, 2015

  
• Analysis of mechanism for stabilizing inward open conformation of human MDR1

  Tomomi Tsuyama; Yasuhisa Kimura; Noriyuki Kioka; Hiraoki Kato; Kaztumitsu Ueda

  日本農芸化学会2015年度大会, 2015

  
• 細胞外マトリクスの硬さ感知におけるビンキュリンのアクチン繊維結合能の重要性

  Tomohiro Omachi; Takafumi Ichikawa; Yasuhisa Kimura; Kazumitsu Ueda; Noriyuki Kioka

  日本農芸化学会2015年度大会, 2015

  
• An amphipathic helix in vinexin α interacts with vinculin

  Naoya Hino; Takafumi Ichikawa; Yasuhisa Kimura; Kazumitsu Ueda; Noriyuki Kioka

  日本農芸化学会2015年度大会, 2015

  
• 「細胞外マトリックスの硬さ」に依存した脂肪細胞分化には接着斑タンパク質ビンキュリンが必要である

  Mito Kuroda; Hiroki Wada; Kazumitsu Ueda; Noriyuki Kioka

  The 15th International Membrane Research Forum, 2015

  
• HDL産生時にABCA1は輸送したコレステロールを一時的に細胞外ドメイン内に蓄積する

  Masato Ishigami; Kohjiro Nagao; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  日本農芸化学会関西支部例会第488回講演会, 2015

  
• ビンキュリン-ビネキシンα相互作用は細胞外マトリクスの硬さを感知するメカノセンサーである

  Noriyuki Kioka; Takafumi Ichikawa; Hiroshi Yamashita; Ayaka Nagasato; Mito Kuroda

  平成26年度「がん研究分野の特性等を踏まえた支援活動」公開シンポジウム, 2015

  
• Interaction of the vinculin proline-rich linker region with vinexin alpha in sensing extracellular matrix stiffness

  Takafumi Ichikawa; Hiroshi Yamashita; Yasuhisa Kimura; Kazumitsu Ueda; Noriyuki Kioka

  日本癌学会シンポジウム/共同利用・共同研究拠点シンポジウム「がん幹細胞・微小環境・分子標的 〜がん進展制御への挑戦」, 2015

  
• Loss of Dlg5 expression promotes the migration and invasion of prostate cancer cells via Girdin phosphorylation.

  L. Tomiyama; T. Sezaki; M. Matsuo; K. Ueda; N. Kioka

  MOLECULAR BIOLOGY OF THE CELL, Dec. 2014

  
• Distribution of vinculin to lipid rafts is involved in sensing ECM stiffness

  A. Nagasato; H. Yamashita; M. Matsuo; K. Ueda; N. Kioka

  MOLECULAR BIOLOGY OF THE CELL, Dec. 2014

  
• Comparison of the effect of the vinexin family proteins on vinculin-mediated mechanosensing.

  T. Ichikawa; M. Kita; T. Sezaki; S. Chiang; A. R. Saltiel; Y. Kimura; K. Ueda; N. Kioka

  MOLECULAR BIOLOGY OF THE CELL, Dec. 2014

  
• The role of the interaction of the vinculin proline-rich linker region with vinexin alpha in sensing the stiffness of the extracellular matrix

  Hiroshi Yamashita; Takafumi Ichikawa; Daisuke Matsuyama; Yasuhisa Kimura; Kazumitsu Ueda; Susan W. Craig; Ichiro Harada; Noriyuki Kioka

  JOURNAL OF CELL SCIENCE, May 2014

  
• Focal adhesion protein vinculin is required for ECM-rigidity dependency of adipocyte differentiation

  黒田美都; 和田洋樹; 植田和光; 木岡紀幸

  日本農芸化学会2014年度大会, 2014

  
• Phosphatidylcholine Efflux by ABCB4 is dependent on Sphingomyelin

  趙 禹; 石神正登; 長尾耕治郎; 花田健太郎; 松尾道憲; 木岡紀幸; 植田和光

  日本農芸化学会2014年度大会, 2014

  
• The analysis of the substrates entry gates of human MDR1

  井上修一; 木村泰久; 木岡紀幸; 松尾道憲; 加藤博章; 植田和光

  日本農芸化学会2014年度大会, 2014

  
• N-terminal region of vinexin α is required for sensing extracellular matrix stiffness

  市川尚文; 山下寛; 木村泰久; 植田和光; 木岡紀幸

  日本農芸化学会2014年度大会, 2014

  
• Functional analysis of human ABC transporter with purified protein.

  木村泰久; 平山裕士; 井上修一; 津山智美; 木岡紀幸; 松尾道憲; 加藤博章; 植田和光

  日本農芸化学会2014年度大会, 2014

  
• Comparison of the affinity to common binding proteins and the effect on focal adhesions among vinexin family (Sorbs) proteins.

  喜多真弘; 市川尚文; 瀬崎拓人; 松尾道憲; 植田和光; 木岡紀幸

  日本農芸化学会2014年度大会, 2014

  
• Physiological effects of omega-3 fatty acids via regulation of lipoprotein quality

  松尾 道憲; 斉藤 貴将; 中塔 充宏; 木岡 紀幸; 小川 順; 植田 和光

  日本農芸化学会2014年度大会, 2014

  
• ECMの硬さ感知に応答したビンキュリンの脂質ラフトへの移行

  長里彩花; 山下寛; 市川尚文; 松尾道憲; 植田和光; 木岡紀幸

  第9回メカノセンシング研究会, 2014

  
• Reconstitution of human ABCA1 in nanodiscs for the functional analysis

  Takaaki Kawanobe; Yasuhisa Kimura; Noriyuki Kioka; Kaztumitsu Ueda

  2014 Annual Meeting of The American Society for Cell Biology, 2014

  
• Identification of hydrophobic amino acids involved in substrate recognition of human MDR1

  Tomomi Tsuyama; Yasuhisa Kimura; Noriyuki Kioka; Hiraoki Kato; Kaztumitsu Ueda

  第37回日本分子生物学会, 2014

  
• Focal adhesion protein vinexin is involved in chondrocyte differentiation

  Yuki Wantani; Yasuhisa Kimura; Kazumitsu Ueda; Noriyuki Kioka

  第87回日本生化学会大会, 2014

  
• Distribution of vinculin to lipid rafts is required for vinculin to sense ECM stiffness

  Ayaka Nagasato; Hiroshi Yamashita; Takafumi Ichikawa; Michinori Matsuo; Kazumitsu Ueda; Noriyuki Kioka

  第87回日本生化学会大会, 2014

  
• Functional analysis of human ABCG4 with purified protein

  Yasuhisa Kimura; Hiroshi Hirayama; Noriyuki Kioka; Michinori Matsuo; Kazumitsu Ueda

  第87回日本生化学会大会, 2014

  
• Effects of vinculin on ECM-stiffness dependent adipocyte differentiation of mesenchymal stem cells

  Mito Kuroda; Hiroki Wada; Kazumitsu Ueda; Noriyuki Kioka

  第87回日本生化学会大会, 2014

  
• 軟骨細胞分化における接着斑タンパク質ビネキシンの役割

  Yuki Wantani; Yasuhisa Kimura; Kazumitsu Ueda; Noriyuki Kioka

  2014年度日本農芸化学会関西支部大会 日本農芸化学会創立90周年・関西支部創立80周年記念大会 「食と生命を科学して80周年?そして未来へ」, 2014

  
• Focal adhesion protein vinculin is required for ECM-stiffness dependent adipocyte differentiation of mesenchymal stem cells.

  Mito Kuroda; Hiroki Wada; Kazumitsu Ueda; Noriyuki Kioka

  第19回日本肥満学会アディポサイエンスシンポジウム, 2014

  
• Functional analysis of TM4 and TM10 of human MDR1 as substrateentry gates.

  井上修一; 木村泰久; 木岡紀幸; 松尾道憲; 加藤博章; 植田和光

  第36回日本分子生物学会, 2013

  
• The analysis of the aromatic residues involved in substrate recognition of human MDR1

  津山智美; 木村泰久; 木岡紀幸; 松尾道憲; 加藤博章; 植田和光

  第36回日本分子生物学会, 2013

  
• Comparison of the effect of vinexin family (Sorbs) proteins on focal adhesions

  喜多真弘; 市川尚文; 瀬崎拓人; 松尾道憲; 植田和光; 木岡紀幸

  第36回日本分子生物学会, 2013

  
• Focal adhesion protein vinculin is required for suppression of ECM-rigidity dependent adipocyte differentiation of mesenchymal stem cells

  黒田美都; 和田洋樹; 植田和光; 木岡紀幸

  第36回日本分子生物学会, 2013

  
• 細胞外マトリックスの硬さを感知するメカノセンサーとしての“接着斑”

  木岡紀幸

  理研シンポジウム「最先端光計測とライフサイエンスの近未来-バイオラマン2017-, 2013

  
• Interaction of vinculin proline-rich linker region with vinexin alpha is involved in sensing extracellular matrix stiffness

  市川尚文; 山下寛; 木村泰久; 植田和光; 木岡紀幸

  第36回日本分子生物学会, 2013

  
• Functional analysis of human ABCB6 with purified protein

  大貫元; 木村泰久; 松尾道憲; 木岡紀幸; 植田和光

  Bordeaux-Kyoto Symposium, 2013

  
• Vinexin is required for the strengtheing of actin stress fiber depending on ECM stiffness

  市川尚文; 山下寛; 木村泰久; 植田和光; 木岡紀幸

  日本農芸化学会2013年度大会, 2013

  
• Adipocyte differentiation of mesenchymal stem cells is regulated by vinculin and vinexin

  和田洋樹; 山下寛; 植田和光; 木岡紀幸

  日本農芸化学会2013年度大会, 2013

  
• Vinculin localization at lipid rafts requires an interaction with PIP2

  長里彩花; 山下寛; 市川尚文; 松尾道憲; 植田和光; 木岡紀幸

  日本農芸化学会2013年度大会, 2013

  
• Vinexin-dependent distribution of vinculin to lipid rafts stabilizes vinculin at focal adhesions.

  H. Yamashita; A. Nagasato; T. Ichikawa; M. Matsuo; K. Ueda; N. Kioka

  MOLECULAR BIOLOGY OF THE CELL, 2012

  
• Roles of Dlg5, a Crohn's disease associated protein, as a regulator of TGF-beta signals and epithelial to mesenchymal transition

  T. Sezaki; K. Inada; L. Tomiyama; K. Ueda; N. Kioka

  MOLECULAR BIOLOGY OF THE CELL, 2012

  
• Analysis of interaction site between KATP channel subunits.

  井上修一; 木村泰久; 木岡紀幸; 松尾道憲; 植田和光

  第85回日本生化学会大会, 2012

  
• Construction of Vinexin Family (Sorbs) Protein Triple KO/KD cell

  喜多真弘; 市川尚文; 瀬崎拓人; 松尾道憲; 植田和光; 木岡紀幸

  第35回日本分子生物学会, 2012

  
• Purification and functional analysis of human ABCB6

  大貫元; 木村泰久; 松尾道憲; 木岡紀幸; 植田和光

  第85回日本生化学会大会, 2012

  
• Purification of ATP sensitive potassium channel complex and determination of subunit structure by single particle analysis.

  YASUHISA KIMURA; Ryo Kanno; Michinori Matsuo; Noriyuki Kioka; Kaoru Mitsuoka; Hiroaki Kato; Kazumitsu Ueda

  第35回日本分子生物学会年会, 2012

  
• Vinculin-vinexin alpha interaction plays a key role in sensing extracellular matrix stiffness

  T. Ichikawa; H. Yamashita; Y. Kimura; I. Harada; K. Ueda; N. Kioka

  MOLECULAR BIOLOGY OF THE CELL, 2012

  
• クローン病関連タンパク質Dlg5とTGF-bI型及びII型受容体との相互作用

  瀬崎 拓人; Lucia Tomiyama; 植田 和光; 木岡 紀幸

  2012年度農芸化学会関西支部大会, 2012

  
• ヒトABCG1の大量発現、精製及び活性評価

  平山裕士; 木村泰久; 松尾道憲; 木岡紀幸; 植田和光

  第７回トランスポーター研究会, 2012

  
• Single particle analysis of KATP channel complex

  木村泰久; 菅野亮; 松尾道憲; 木岡紀幸; 光岡薫; 加藤博章; 植田和光

  日本顕微鏡学会 第６８回研究会, 2012

  
• Vinexin is involeved in the focal adhesion-mediated mechanosensing

  山下 寛; 市川 尚文; 松山 大輔; 植田 和光; 木岡 紀幸

  2012年度日本農芸化学会, 2012

  
• Behavior of focal adhesion protein vinculin is altered by rigidity of extracellular matrix in mesenchymal stem cells.

  和田 洋樹; 山下 寛; 植田 和光; 木岡 紀幸

  2012年度日本農芸化学会, 2012

  
• Vinculin, a focal adhesion protein, localizes at lipid rafts.

  長里 彩花; 山下 寛; 市川 尚文; 植田 和光; 木岡 紀幸

  2012年度日本農芸化学会, 2012

  
• Identification of the binding site on Dlg5 for TGF-b type I receptor.

  瀬崎 拓人; 市川 尚文; Lucia Tomiyama; 植田 和光; 木岡 紀幸

  2012年度日本農芸化学会, 2012

  
• Vinexin promotes vinculin activation

  市川 尚文; 山下 寛; 木村 泰久; 植田 和光; 木岡 紀幸

  2012年度日本農芸化学会, 2012

  
• Purification of human ABCG1 and its functional analysis

  平山裕士; 木村泰久; 松尾道憲; 木岡紀幸; 植田和光

  2012年度日本農芸化学会, 2012

  
• Large scale production and purification of mammalian membrane proteins in human cells ? purification of KATP channel complex ?

  木村泰久; 菅野亮; 松尾道憲; 木岡紀幸; 光岡薫; 加藤博章; 植田和光

  2012年度日本農芸化学会, 2012

  
• Large scale expression and purification of human ABCB6 in insect cells

  大貫元; 木村泰久; 松尾道憲; 木岡紀幸; 植田和光

  2012年度日本農芸化学会, 2012

  
• Activation of protein quality control systems induced by food chemicals

  大西 康太; 中畑 恵利奈; 石坂 朱里; 河合 慶親; 寺尾 純二; 木岡 紀幸; 入江 一浩; 村上 明

  2012年度日本農芸化学会, 2012

  
• Interaction through intrinsic disordered regions is involved in sensing extracellular microenvironment

  木岡紀幸

  2012年度日本農芸化学会, 2012

  
• Both specific and non-specific protein modifications by zerumbone may contribute to its bioactivities.

  Kohta Ohnishi; Akari Ishisaka; Taiki Mori; Yoshichika Kawai; Junji Terao; Takeshi Ishii; Tsutomu Nakayama; Noriyuki Kioka; Kazuhiro Irie; Akira Murakami

  The 5th International Conference on Food Factors, Nov. 2011, Peer-reviewed

  
• ヒト培養細胞による哺乳類膜タンパク質の大量発現系

  木村泰久; 菅野亮; 松尾道憲; 木岡紀幸; 光岡薫; 加藤博章; 植田和光

  第6回 トランスポーター研究会年会, 11 Jun. 2011

  
• Large scale production and purification of mammalian membrane proteins in human cells ? a case study of KATP channel complex ?

  木村泰久; 菅野亮; 松尾道憲; 木岡紀幸; 光岡薫; 加藤博章; 植田和光

  第37回 日本生体エネルギー研究会, 2011

  
• 高密度リポタンパク質(HDL)産生機構の解析? ABCA1のATPに依存した構造変化とapoA-I結合

  長尾耕治郎; 木村泰久; 松尾道憲; 木岡紀幸; 植田和光

  2011年度 日本農芸化学会関西・中部支部合同大会, 2011

  
• Vinexin-dependent interaction of vinculin with lipid rafts.

  山下 寛; 市川 尚文; 長里 彩花; 植田 和光; 木岡 紀幸

  第84回日本生化学会大会, 2011

  
• Purification of liver X receptor b expressed in E. coli

  竹田知世; 木村泰久; 木岡紀幸; 植田和光

  第84回日本生化学会大会, 2011

  
• ABCA1 is regulated by leucine-zipper-like motif at the COOH-terminal region

  永岩耕太; 長尾耕治郎; 木村泰久; 松尾道憲; 木岡紀幸; 植田和光

  第84回日本生化学会大会, 2011

  
• Purification and functional analysis of human ABCG1 in cultured human cells.

  平山裕士; 木村泰久; 松尾道憲; 木岡紀幸; 植田和光

  第84回日本生化学会大会, 2011

  
• ATP hydrolysis-dependent conformational changes of extra cellular domains of ABCA1 are necessary for apoA-I binding

  長尾耕治郎; 高橋圭; 吾妻佑哉; 木村泰久; 松尾道憲; 木岡紀幸; 植田和光

  第84回日本生化学会大会, 2011

  
• Vinexin promotes Vinculin-F-actin complex formation

  市川 尚文; 山下 寛; 木村 泰久; 植田 和光; 木岡 紀幸

  第84回日本生化学会大会, 2011

  
• Crohn's disease associated protein Dlg5/lp-dlg promotes TGF-beta receptor degradation

  瀬崎 拓人; Lucia Tomiyama; 稲田 康輝; 植田 和光; 木岡 紀幸

  第84回日本生化学会大会, 2011

  
• Large scale production and purification of mammalian membrane proteins in human cells

  木村泰久; 菅野亮; 松尾道憲; 木岡紀幸; 光岡薫; 加藤博章; 植田和光

  第84回日本生化学会大会, 2011

  
• PKA forms a complex with WAVE2 and controls lamellipodia formation

  YAMASHITA Hiroshi; UEDA Kazumitsu; KIOKA Noriyuki

  日本細胞生物学会大会要旨集, 07 May 2010, Peer-reviewed

  
• ビネキシンとビンキュリンの結合は接着班のビンキュリンを安定化させる

  木岡紀幸

  BMB2010, 2010, Peer-reviewed

  
• クローン病関連因子Dlg5によるTGF-シグナル経路の制御

  木岡紀幸

  日本農芸化学会2011年度大会, 2010, Peer-reviewed

  
• メカノセンサーとしてのビネキシン-ビンキュリン相互作用

  木岡紀幸

  日本農芸化学会2011年度大会, 2010, Peer-reviewed

  
• 表皮細胞の運動と創傷治癒における細胞接着関連タンパク質ビネキシンの重要性

  木岡紀幸

  2010年度日本農芸化学会関西支部大会, 2010, Peer-reviewed

  
• ビネキシンは接着斑におけるビンキュリンの動態を調節する

  Noriyuki Kioka

  Gordon Conferences "Signaling by adhesion receptor", 2010, Peer-reviewed

  
• ヒト多剤トランスポーター（MDR1）の基質認識におけるコレステロールの寄与：コレステロール充填モデル

  木岡紀幸

  第5回トランスポーター研究会年会, 2010, Peer-reviewed

  
• Novel post-translational regulation of ABCA1 in HDL formation

  Noriyuki Kioka

  Keystone Symposia Bioactive Lipids: Biochemistry and Diseases, 2010, Peer-reviewed

  
• A novel post-translational regulation of ABCA1 to keep ABCA1 on standby for HDL formation in acute cholesterol accumulation

  Noriyuki Kioka

  HDL 2010 Workshop, 2010, Peer-reviewed

  
• Zerumbone is covalently bound to the key proteins involved in inflammatory and self-defense mechanisms

  Noriyuki Kioka

  The 2010 International Chemical Congress of Pacific Basin Societies, 2010, Peer-reviewed

  
• ヒト培養細胞を用いたATP感受性カリウムチャネルの大量発現・精製手法の開発

  KIMURA YASUHISA; HIRAYAMA HIROSHI; KIOKA NORIYUKI; MATSUO MICHINORI; KATO HIROAKI; UEDA KAZUMITSU

  生化学, 25 Sep. 2009

  
• ヒト培養細胞を用いたATP感受性カリウムチャネル複合体の大量生産,高純度精製

  KIMURA YASUHISA; HIRAYAMA YUJI; MATSUO MICHINORI; KIOKA NORIYUKI; KATO HIROAKI; UEDA KAZUMITSU

  日本農芸化学会大会講演要旨集, 05 Mar. 2009

  
• クローン病関連タンパク質Dlg5/lp-dlgによるLLc-PK1細胞の上皮間葉転換の制御機構

  木岡紀幸

  第82回 日本生化学会大会, 2009, Peer-reviewed

  
• PKAによる細胞運動制御機構の解析

  木岡紀幸

  第82回 日本生化学会大会, 2009, Peer-reviewed

  
• Crohn’s Disease Associated Protein Dlg5/Lp-Dlg Controls Epithelial Mesenchymal Transition in Llcpk1

  Noriyuki Kioka

  ASCB 49th Annual Meeting, 2009, Peer-reviewed

  
• PKA Forms a Complex with WAVE2 and Controls Lamellipodia Formation.

  Noriyuki Kioka

  ASCB 49th Annual Meeting, 2009, Peer-reviewed

  
• アクチン重合活性化タンパク質WAVE2はPKAと複合体を形成する

  木岡紀幸

  日本農芸化学会2009年大会, 2009, Peer-reviewed

  
• ヒト培養細胞を用いたヒトABCタンパク質大量発現・精製手法の構築

  KIMURA YASUHISA; HIRAYAMA YUJI; KIOKA NORIYUKI; MATSUO MICHINORI; KATO HIROAKI; UEDA KAZUMITSU

  日本農芸化学会関西支部講演会講演要旨集, 10 Sep. 2008

  
• Enhanced clustering of .ALPHA.5 integrin and fibronectin fibrillogenesis in vinexin deficient mouse embryonic fibroblasts

  TAKAHASHI Honami; TAKEGAMI Megumi; SOGABE Takayuki; UEDA Kazumitsu; KIOKA Noriyuki

  日本細胞生物学会大会要旨集, 05 Jun. 2008, Peer-reviewed

  
• ヒト培養細胞を用いたヒトABCトランスポーターの大量発現系の構築および精製条件スクリーニング手法の開発

  KIMURA YASUHISA; HIRAYAMA YUJI; ASAMI NARUMI; KIOKA NORIYUKI; MATSUO MICHINORI; KATO HIROAKI; UEDA KAZUMITSU

  生化学, 2008

  
• Dlg5/lp-dlgによるLLc-PK1細胞の上皮間葉転換の制御

  木岡紀幸

  平成20年度日本農芸化学会関西支部大会, 2008, Peer-reviewed

  
• ビネキシン欠損細胞でのフィブロネクチン繊維化の亢進

  木岡紀幸

  第55回マトリックス研究会大会・第40回 日本結合組織学会学術大会, 2008, Peer-reviewed

  
• がん遺伝子v-Src形質転換細胞におけるインテグリン裏打ちタンパク質ビネキシンのチロシンリン酸化

  木岡紀幸

  日本農芸化学会2008年大会, 2008, Peer-reviewed

  
• Roles of Dlg5/lp-dlg in epithelial to mesenchymal transition of LLc-PK1 cells

  Noriyuki Kioka

  第60回 日本細胞生物学会大会, 2008, Peer-reviewed

  
• A crucial role of vinexin for keratinocyte migration in vitro and epidermal wound healing in vivo

  Noriyuki Kioka

  第60回 日本細胞生物学会大会, 2008, Peer-reviewed

  
• WAVE2はPKAホロ酵素と複合体を形成する」

  木岡紀幸

  第31回 日本分子生物学会年会・第81回 日本生化学会大会 合同大会, 2008, Peer-reviewed

  
• Focal adhesion protein vinexin interacts with and stabilizes Wasp-family verprolin-homologous protein (WAVE) 2

  Masaru Mitushima; Takuhito Sezaki; Rje Akahane; Kazumitsu Ueda; Shiro Suetsugu; Tadaomi Takenawa; Noriyuki Kioka

  CELL STRUCTURE AND FUNCTION, Jun. 2005

  
• ERK2 activated by EGF and cell adhesion interacts with and phosphorylates vinexin

  O. Masaru Mitsushima; Kazumitsu Ueda; Noriyuki Kioka

  CELL STRUCTURE AND FUNCTION, May 2004

  
• Functional analysis of ABCA3, an ABC protein highly expressed in alveolar type II cells

  Koh Nagata; Michinori Matsuo; Noriyuki Kioka; Nobuhiro Ban; Nobuya Inagaki; Kazumitsu Ueda

  CELL STRUCTURE AND FUNCTION, May 2004

  
• Effects of mutations of ABCA1 in the first extracellular domain on subcellular trafficking and ATP binding/hydrolysis. (vol 278, pg 8815, 2003)

  AR Tanaka; S Abe-Dohmae; T Ohnishi; R Aoki; G Morinaga; K Okuhira; Y Ikeda; F Kano; M Matsuo; N Kioka; T Amachi; M Murata; S Yokoyama; K Ueda

  JOURNAL OF BIOLOGICAL CHEMISTRY, Apr. 2003

  
• Fuel adhesion targeting of vinexin beta reveals a requirement for adhesion-dependent exposure of the polyproline region of vinculin

  DM Cohen; SW Craig; N Kioka

  MOLECULAR BIOLOGY OF THE CELL, Nov. 2002

  
• ヒトMDR1の昆虫細胞での大量発現,精製及びATP加水分解活性の測定

  KIMURA YASUHISA; MORINAGA MANABU; MATSUO MICHINORI; MATSUMOTO TAKASHI; KATO HIROAKI; KIOKA NORIYUKI; AMACHI TERUO; UEDA KAZUMITSU

  日本農芸化学会誌, 05 Mar. 2001

  
• Comparative aspects of the function and mechanism of SUR1 and MDR1 proteins

  K Ueda; M Matsuo; K Tanabe; K Morita; N Kioka; T Amachi

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Dec. 1999

  
• Behavior of the 100-kDa protein, a novel mammalian splicing factor, in mouse preimplantation embryos.

  A Nishikimi; J Mukai; N Kioka; M Yamada

  BIOLOGY OF REPRODUCTION, 1999

  
• Effects of integrin activation on cell proliferation and the cell cycle.

  N Kioka; MJ Humphries; SK Akiyama

  FASEB JOURNAL, Apr. 1996

  
• Structures Directing Initiation of DNA Synthesis on Single-strand DNA Templates

  H. Sakai; J. D. Bahk; H. Hiasa; Y. Honda; K. Iwamoto; T. Horimoto; N. Kioka; G. N. Godson; T. Komano

  A Pre-symposium to the 14th International Congress of Biochemistry, Local Changes in DNA Structure and their Biological Implications, 1988, Peer-reviewed

  
• Substrate entry mechanism of human MDR1

  Yasuhisa Kimura; Shuichi Inoue; Noriyuki Kioka; Kazumitsu Ueda

  7th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”

  
• Analyses of chimera proteins of ABCA1 suggest the importance of the C-terminal domain of ABCA2 and ABCA13, linked to the Alzheimer’s disease and schizophrenia

  〇Yusuke Okamoto; Koh Nagata; Rinshi Kasai; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  7th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”

  
• Functional analysis of transmembrane helix 4 of human ABCB4

  〇Shun Ogawa; Kento Suenaga; Noriyuki Kioka; Yasuhisa Kimura; Kazumitsu Ueda

  7th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”

  
• Live cell analysis of the conformational changes in human multidrug transporter MDR1

  〇Ryota Futamata; Fumihiko; Ogasawara; Takafumi Ichikawa; Yasuhisa Kimura; Noriyuki Kioka; Kazumitsu Ueda

  7th FEBS special meeting “ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases”

  
• キメラタンパク質を用いたABCAサブファミリータンパク質のC末端領域の機能解析

  岡本雄介; 永田紅; 笠井倫志; 木村泰久; 木岡紀幸; 植田和光

  日本農芸化学会 2018年度大会

  
• 超音波処理を用いた接着斑単離法の確立

  柴原正和; 市川尚文; 箕浦広大; 木村泰久; 植田和光; 木岡紀幸

  日本農芸化学会 2018年度大会

  
• リン脂質輸送体ABCB4の 基質取り込みゲートの解析

  小川峻; 末永健人; 木岡紀幸; 木村泰久; 植田和光

  日本農芸化学会 2018年度大会

  
• 間葉系幹細胞の細胞外基質の硬さに対する応答におけるSORBSファミリータンパク質の役割

  黒田美都; 植田和光; 木岡紀幸

  日本農芸化学会 2018年度大会

  
• ヒト多剤排出ポンプMDR1 (ABCB1)の構造変化において ATPが果たす役割の検討

  二股良太; 小笠原史彦; 市川尚文; 木村泰久; 木岡紀幸; 植田和光

  日本農芸化学会2018年度名古屋大会

  
• ヒトABCB4の第4膜貫通ヘリックスの機能解析

  小川峻; 末永健人; 木岡紀幸; 木村泰久; 植田和光

  2017年度生命科学系学会合同年次大会

  
• ABCA1は細胞内でコレステロールを動かすことによって細胞遊走を制御する

  伊藤志帆; 木岡紀幸; 植田和光

  2017年度生命科学系学会合同年次大会

  
• 接着斑タンパク質ビネキシンがレチノイン酸により制御される間葉系幹細胞分化に与える効果

  高田恭子; 黒田美都; 木村泰久; 植田和光; 木岡紀幸

  2017年度生命科学系学会合同年次大会

  
• 接着斑タンパク質ビネキシンおよびCAPはYAP/TAZの核局在を調節する

  黒田美都; 植田和光; 木岡紀幸

  2017年度生命科学系学会合同年次大会

  
• 細胞外マトリックスの硬さによる細胞分化制御へのビンキュリンーYAP/TAZ系の関与

  黒田美都; 市川尚文; 長里彩花; 大町朋弘; 木村泰久; 植田和光; 木岡紀幸

  2017年度生命科学系学会合同年次大会

  
• ポルフィリンのカルボキシル基はヒトABCB6によるポルフィリン認識に重要である

  西澤奈美; 木村泰久; 大貫元; 木岡紀幸; 植田和光

  2017年度生命科学系学会合同年次大会, 2017

  
• 定量的アプローチによるABCA1とapoA-Iによる脂質排出メカニズムの解明

  三好里奈; 小笠原史彦; 石神正登; 永田紅; 木村泰久; 木岡紀幸; 植田和光

  2017年度生命科学系学会合同年次大会

  
• 分子内FRETを用いたヒト多剤 排出ポンプMDR1(ABCB1)の 構造変化解析手法の確立

  二股良太; 小笠原史彦; 市川尚文; 木村泰久; 木岡紀幸; 植田和光

  2017年度生命科学系学会合同年次大会

  
• ヒトABCB4の基質取り込み経路の検討

  小川峻; 末永健人; 木岡紀幸; 木村泰久; 植田和光

  日本農芸化学会 関西・中四国・ 西日本支部 2017年度 合同大阪大会, 2017

  
• 分子内FRETを用いたヒト多剤排出ポンプMDR1(ABCB1)変異体の構造変化解析

  二股良太; 小笠原史彦; 市川尚文; 木村泰久; 木岡紀幸; 植田和光

  日本農芸化学会 関西・中四国・ 西日本支部 2017年度 合同大阪大会

  
• 間葉系幹細胞の脂肪細胞分化におけるビネキシンファミリータンパク質の役割

  黒田美都; 植田和光; 木岡紀幸

  第22回アディポサイエンス・シンポジウム

  
• 細胞遊走とコレステロール合成に与えるABCA1の影響

  伊藤志帆; 木岡紀幸; 植田和光

  第69回日本細胞生物学会大会

  
• ビンキュリンは細胞外基質の硬さに応じてTAZの核局在を促進し、脂肪細胞への分化 を抑制する

  黒田美都; 和田洋樹; 植田和光; 木岡紀幸

  第69回日本細胞生物学会大会

  
• 細胞外基質の硬さの感知と収縮力発生におけるビネキシンファミリータンパク質の役割

  市川尚文; 喜多真弘; 植田和光; 木岡紀幸

  第69回日本細胞生物学会大会

  

Presentations

• 膜領域としての細胞接着斑細胞膜

  木岡 紀幸

  第91回 日本生化学会大会シンポジウム, 26 Sep. 2018

  
• Vinculin and SORBS (vinexin) family proteins in mechanosensing and mechanotransduction

  KIOKA Noriyuki

  3rd International Symposium on Mechanobiology, 12 Dec. 2017, Invited

  
• ECM stiffness-dependent differentiation into adipocytes involves vinculin regulation of YAP/TAZ

  KIOKA Noriyuki

  ConBio2017, 07 Dec. 2017

  
• ビネキシンαの両親媒性ヘリックスはテーリンと協調的にビンキュリンと相互作用する

  日野 直也; 市川 尚文; 木村 泰久; 植田 和光; 木岡 紀幸

  日本細胞生物学会大会講演要旨集, May 2016, (一社)日本細胞生物学会

  
• 接着斑タンパク質ビネキシンαの両親媒性へリックスはビンキュリンの構造変化を引き起こすために必要である

  日野 直也; 市川 尚文; 木村 泰久; 植田 和光; 木岡 紀幸

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015, (公社)日本生化学会

  
• ビネキシンαの両親媒性ヘリックスはビンキュリンの頭部と相互作用する

  日野 直也; 市川 尚文; 木村 泰久; 植田 和光; 木岡 紀幸

  日本細胞生物学会大会講演要旨集, Jun. 2015, (一社)日本細胞生物学会

  
• 細胞外マトリックスの堅さの感知におけるビンキュリン-ビネキシン相互作用

  第３５回日本分子生物学会 ワークショップ, 11 Dec. 2012, 分子生物学会

  

Books and Other Publications

• 糖転移酵素遺伝子の単離と解析

  木岡 紀幸

  遺伝子の構造と機能//学会出版センター,/,173, 1998, Not refereed

  

Works

• ビネキシンによるJNK/SAPKの制御

  From 1999

  
• Regulation ob JNK/SAPK activation by vinexin

  From 1999

  

Awards

• 2003

  農芸化学奨励賞

External funds: Kakenhi

• 細胞外基質による細胞機能制御機構の包括的理解とその応用基盤の研究

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 38:Agricultural chemistry and related fields

  Kyoto University

  木岡 紀幸

  From 05 Apr. 2021, To 31 Mar. 2025, Granted

  接着斑;細胞外マトリックス;細胞分化;メカノバイオロジー;コラーゲン;細胞接着

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04713/
• Does the membrane at focal adhesions differ from other membrane and regulate cellular function?

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 38:Agricultural chemistry and related fields

  Kyoto University

  Noriyuki Kioka

  From 28 Jun. 2019, To 31 Mar. 2023, Project Closed

  接着斑;細胞膜;コラーゲン;リン脂質;細胞外マトリックス;脂質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K22279/
• Molecular mechanism of regulation of cellular functions by extracellular matrix stiffness

  Grant-in-Aid for Scientific Research (B)

  Basic Section 38060:Applied molecular and cellular biology-related

  Kyoto University

  Noriyuki Kioka

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  細胞外マトリックス;コラーゲン;細胞接着;間葉系幹細胞;接着斑;メカノバイオロジー;細胞分化;脂肪細胞;ビンキュリン;骨芽細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02167/
• Approach to identify a novel mechanism which modulates vitaminA regulation of adipocyte differentiation

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Noriyuki Kioka

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  ビタミンA;脂肪細胞;細胞外マトリックス;間葉系幹細胞;コラーゲン;レチノイン酸;分化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15090/
• Exploring a novel mechanism regulating differentiation into beige adipocytes

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Noriyuki Kioka

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  脂肪細胞;コラーゲン;メカノバイオロジー;褐色脂肪;細胞外マトリックス;褐色脂肪細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26660291/
• 細胞外マトリックスの硬さによる上皮管腔組織形成の制御

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  木岡 紀幸

  From 01 Apr. 2014, To 31 Mar. 2016, Project Closed

  細胞外マトリックス;嚢胞;管腔;乳腺上皮細胞;上皮細胞;管腔形成

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-26112707/
• Studies of factors that inhibit the macrophage migration

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Noriyuki KIOKA

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  メタボリック症候群;糖尿病;マクロファージ;細胞遊走;細胞接着;炎症;生活習慣病

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24658094/
• Analysis of molecular mechanim for sensing stiffness of extracellular matrix

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Noriyuki KIOKA

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  細胞外マトリックス;コラーゲン;メカノバイオロジー;がん;接着斑;細胞接着;生体分子;シグナル伝達;細胞・組織;癌;細胞分化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24380185/
• Functional analysis of focal adhesion proteins-sensors and re gulators for microenvironment

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Noriyuki KIOKA

  From 01 Apr. 2008, To 31 Mar. 2012, Project Closed

  細胞接着;がん;細胞骨格;細胞外基質;シグナル伝達;細胞・組織;細胞外基室;コラーゲン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20380186/
• インテグリン裏打ち蛋白質とがん細胞の接着・運動制御

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  木岡 紀幸

  From 01 Apr. 2005, To 31 Mar. 2008, Project Closed

  細胞接着;細胞骨格;アクチン;上皮間葉転換;ビネキシン;がん;細胞運動;シグナル伝達

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17014045/
• PhYsiological function of focal adiesion protein vinexin

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Noriyuki KIOKA

  From 01 Apr. 2004, To 31 Mar. 2008, Project Closed

  細胞運動;創傷治癒;上皮間葉転換;細胞接着;シグナル伝達;がん;再生医学;ビネキシン;細胞骨格;分化;アクチン;浸潤;足場依存性, Cell Adhesion;Wound healing;Tumorigenesis;Migration;Signal transduction

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16380229/
• ABC蛋白の多機能性と生命維持機構

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  植田 和光

  From 01 Apr. 2003, To 31 Mar. 2004, Project Closed

  ABC蛋白質;生活習慣病;コレステロール;糖尿病;癌;トランスポーター;ABCタンパク質;チャネル;動脈硬化;膜タンパク質;構造解析;遺伝病;ATP;レセプター

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10217101/
• Analysis of physiological function of a focal adhesion protein vinexin

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Noriyuki KIOKA

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  細胞接着;ビネキシン;ビンチュリン;足場依存性;裏打ちタンパク質;ビンキュリン;細胞骨格;アクチン;裏打ち蛋白質, Cell Adhesion;Vinexin;Vinculin;Anchorage-dependence;foal adhesion protein

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14560287/
• Molecular mechanism of ATP-dependent transporters involved in cholesterol homeostasis

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Kazumitsu UEDA

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  コレステロール;トランスポーター;ABCタンパク質;動脈硬化;3次元構造解析;高脂血症;ABCA1;糖尿病;生活習慣病;リン脂質;構造解析, ABC proteins;cholesterol;atherosclerosis;α1-syntrophin;lipid;HDL;transporter;membrane

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14360053/
• 細胞膜裏打ち蛋白質による足場依存的細胞増殖と浸潤の制御

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  木岡 紀幸

  From 01 Apr. 2002, To 31 Mar. 2005, Project Closed

  細胞密着;細胞骨格;アクチン;ビネキシン;ビンキュリン;足場依存性;細胞接着;裏打ち蛋白質;増殖シグナル;MARK

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13216050/
• 細胞の増殖シグナル及び癌の浸潤転移における新規裏打蛋白質ビネキシンの機能解析

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Kyoto University

  木岡 紀幸

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  ビネキシン;足場依存性;増殖シグナル;ビンキュリン;MAPK;細胞接着;足場依存;細胞増殖;MAPキナーゼ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12760054/
• 細胞の増殖シグナル及び癌の浸潤転移における新規裏打蛋白質ビネキシンの機能解析

  Grant-in-Aid for Scientific Research on Priority Areas (C)

  Biological Sciences

  Kyoto University

  木岡 紀幸

  From 01 Apr. 2000, To 31 Mar. 2002, Project Closed

  細胞接着;ビンキュリン;足場依存;細胞増殖;MAPキナーゼ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12215075/
• Comprehensive study on the regulation of metabolism of lipids including long-chain fatty acids and very-long-chain faty acids

  Grant-in-Aid for Scientific Research (B)

  KYOTO UNIVERSITY

  Teruo AMACHI

  From 01 Apr. 1999, To 31 Mar. 2002, Project Closed

  脂肪酸;コレステロール;リン脂質;ABCタンパク質;トランスポーター;ペルオキシソーム;ABCA1;動脈硬化;ATP;遺伝子;クローニング;ベーター酸化, fatty acids;cholesterol;phospholipids;ABC proteins;transporter;peroxisome;ABCA1;atherosclerosis

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11460044/
• 裏打蛋白ビネキシンとSosの相互作用からみた細胞骨格とシグナル伝達のクロストーク

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Biological Sciences

  Kyoto University

  木岡 紀幸

  From 01 Apr. 1999, To 31 Mar. 2000, Project Closed

  SH3;Signal Transduction;JNK;Sos;vinculin

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11160208/
• ABC蛋白の機能の多様性の分子基盤

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  植田 和光

  From 01 Apr. 1998, To 31 Mar. 2003, Project Closed

  ABCタンパク質;トランスポーター;チャネル;動脈硬化;膜タンパク質;コレステロール;自己免疫疾患;生活習慣病;糖尿病;癌;遺伝病;ATP;レセプター;残耐射性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10217205/
• A novel signal transduction mechanism via intracellular ATP sensor

  Grant-in-Aid for Scientific Research (C)

  KYOTO UNIVERSITY

  Kazumitsu UEDA

  From 01 Apr. 1997, To 31 Mar. 1999, Project Closed

  ABCタンパク質;トランスポーター;K^+チャネル;CFTR;MDRI;SUR;シグナル伝達;ATP;P-糖タンパク質;MDR;MRP;糖尿病;癌;ABCス-パファミリー;k^+チャネル;多剤耐性;分子生物学;生化学, ABC proteins;transporter;K^+ channel;CFTR;MDRI;SUR;signal transductron;ATP

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09660086/
• Molecular design of anti-metastatic sugars from lipophilic anti-invasive sugar derivatives

  Grant-in-Aid for Scientific Research (B).

  Mie University

  Naoki KASHIMURA

  From 01 Apr. 1997, To 31 Mar. 2001, Project Closed

  脂溶性糖質;がん転移阻害活性;ヒト培養がん細胞株;抗接着作用;部分ベンジル化糖;プリン誘導体;細胞接着阻害;がん転移阻害;抗炎症活性;部分置換糖質;ヒトがん細胞;マウス乳がん細胞;脂溶性糖質誘導体;がん転移自然モデル;がん転移血行モデル;細胞毒性;トリチルヌクレオシド;トリチルシクロデキストリン;がん転移;血管内皮細胞;接着分子;がん細胞浸潤;トリチル化糖, lipophilic sugars;antimetstatic activities;human cancer cell lines;antiadhesive action;partially benzylated sugars;purine derivatives

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09556022/
• N-アセチルグルコサミン転移酵素I遺伝子の発現制御機構と機能の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  駒野 徹

  From 01 Apr. 1993, To 31 Mar. 1994, Project Closed

  Glycosyltransferase;N-acetylglucosaminyltransferase

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05274213/
• P糖蛋白質の物質輸送およびチャネル活性とATP加水分解の共役

  Grant-in-Aid for Scientific Research on Priority Areas

  Kyoto University

  植田 和光

  From 01 Apr. 1993, To 31 Mar. 1994, Project Closed

  多剤耐性;P-糖蛋白質;MDR1遺伝子;癌;トランスポーター;ATPase;クロライドチャネル;酵母

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05259214/
• P-糖蛋白質の正常機能解析と誘導発現機構解析に基づいた多剤耐性克服法の開発

  Grant-in-Aid for Cancer Research

  Kyoto University

  植田 和光

  From 01 Apr. 1993, To 31 Mar. 1994, Project Closed

  P糖蛋白質;多剤耐性;癌;抗癌剤;トランスポーター;癌遺伝子;ステロイドホルモン;シクロスポリンA

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05152066/
• Molecular mechanism of steroid transporter P-glycoprotein

  Grant-in-Aid for General Scientific Research (C)

  KYOTO UNIVERSITY

  Kazumitsu UEDA

  From 01 Apr. 1992, To 31 Mar. 1994, Project Closed

  P-糖蛋白質;多剤耐性;MDR1遺伝子;ステロイドホルモン;物質輸送;分子生物学;癌;トランスポーター;ジゴキシン, P-glycoprotein;Multidrug resistance;Steroid hormone;MDR1 gene;Cancer;Transporter;Chemotherapy

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04660085/
• P-糖蛋白質の正常機能解析と誘導発現機構解析に基づいた多剤耐性克服法の開発

  Grant-in-Aid for Cancer Research

  Kyoto University

  植田 和光

  From 01 Apr. 1992, To 31 Mar. 1993, Project Closed

  多剤耐性;Pー糖蛋白質;MDR1遺伝子;遺伝子発現;癌遺伝子;分子生物学;免疫抑制剤;物質輸送

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04152066/
• Development and application of new regulatory genes

  Grant-in-Aid for General Scientific Research (A)

  Kyoto University

  Tohru KOMANO

  From 01 Apr. 1990, To 31 Mar. 1994, Project Closed

  複製開始領域;Btのプロモーター;SSIシグナル;熱ショックレスポンス;多剤耐性;糖鎖工学;DNA合成開始領域;プライマ-ゼ結合部位;ステム・ル-プ構造;転写調節機構;CRP結合部位;部位特異的変異;融合遺伝子;転写調節部位, Replication initiation region;Promoter of BT;SSI signal;Heat shock response;Multi-drug resistance;Glyco-technology

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02403023/

External funds: others

• Functional Analysis of focal adhesion Proteins in signal transduction and cell differentiation
• Functions of focal adhesion proteins in regulating cytoskeleton and cell migration

  From 2002

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Outline of Physiological Chemistry

  M212, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Cellular Biochemistry

  CA20, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Applied Life Sciences III

  CA03, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Applied Biochemistry

  CA29, Fall, Graduate School of Agriculture, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Cellular Biochemistry Seminar

  CF01, Spring, Graduate School of Agriculture, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Cellular Biochemistry Seminar

  CF01, Fall, Graduate School of Agriculture, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course of Cellular Biochemistry

  CG01, Spring, Graduate School of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course of Cellular Biochemistry

  CG01, Fall, Graduate School of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Outline of Physiological Chemistry

  X101, Fall, Graduate School of Agriculture, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Outline of Applied Life Sciences

  5801, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Molecular Cellular Biology I

  5656, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Applied Life Science III

  5605, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Outline of Physiological Chemistry

  M212, Fall, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Applied Life Sciences III

  CA03, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Cellular Biochemistry

  CA20, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Applied Biochemistry

  CA29, Fall, Graduate School of Agriculture, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Life Sciences IV (Advanced Course)

  CA27, Fall, Graduate School of Agriculture, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Cellular Biochemistry Seminar2

  CB18, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Cellular Biochemistry Seminar1

  CB17, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course of Cellular Biochemistry2

  CC18, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course of Cellular Biochemistry1

  CC17, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Outline of Physiological Chemistry

  X101, Fall, Graduate School of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Applied Life Science III

  5605, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Molecular Cellular Biology I

  5656, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Outline of Physiological Chemistry

  X101, Fall, Graduate School of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Thesis

  5685, Year-long, Faculty of Agriculture, 10
• From 01 Apr. 2022, To 31 Mar. 2023

  Cellular Biochemistry Seminar1

  CB17, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course of Cellular Biochemistry1

  CC17, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Structural Biology

  5638, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Applied Biochemistry

  CA29, Fall, Graduate School of Agriculture, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Applied Life Sciences III

  CA03, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Molecular Cellular Biology I

  5656, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Cellular Biochemistry

  CA20, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course of Cellular Biochemistry2

  CC18, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Cellular Biochemistry Seminar2

  CB18, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Applied Life Science III

  5605, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Outline of Physiological Chemistry

  M212, Fall, Institute for Liberal Arts and Sciences, 2
• From Apr. 2011, To Mar. 2012

  分子細胞生物学I

  Fall, 農学部
• From Apr. 2011, To Mar. 2012

  分子生物学実験

  Fall, 農学部
• From Apr. 2011, To Mar. 2012

  細胞生化学専攻実験

  農学研究科
• From Apr. 2011, To Mar. 2012

  細胞生化学専攻演習

  農学研究科
• From Apr. 2012, To Mar. 2013

  Laboratory Course in Molecular Biology

  Fall, 農学部
• From Apr. 2012, To Mar. 2013

  Molecular Cellular Biology I

  Fall, 農学部
• From Apr. 2013, To Mar. 2014

  Molecular Cellular Biology I

  Fall, 農学部
• From Apr. 2013, To Mar. 2014

  Laboratory Course in Molecular Biology

  Fall, 農学部
• From Apr. 2013, To Mar. 2014

  Cellular Biochemistry

  Fall, 農学研究科
• From Apr. 2013, To Mar. 2014

  Cellular Biochemistry Seminar

  Year-long, 農学研究科
• From Apr. 2013, To Mar. 2014

  Experimental Course of Cellular Biochemistry

  Year-long, 農学研究科
• From Apr. 2014, To Mar. 2015

  Molecular Cellular Biology I

  Fall, 農学部
• From Apr. 2014, To Mar. 2015

  Laboratory Course in Molecular Biology

  Fall, 農学部
• From Apr. 2014, To Mar. 2015

  Applied Life Sciences III

  Spring, 農学研究科
• From Apr. 2014, To Mar. 2015

  Cellular Biochemistry

  Spring, 農学研究科
• From Apr. 2014, To Mar. 2015

  Cellular Biochemistry Seminar

  Year-long, 農学研究科
• From Apr. 2014, To Mar. 2015

  Experimental Course of Cellular Biochemistry

  Year-long, 農学研究科
• From Apr. 2014, To Mar. 2015

  Practice of Basic Informatics(Faculty of Agriculture)

  Fall, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Laboratory Course in Molecular Biology

  Fall, 農学部
• From Apr. 2015, To Mar. 2016

  Molecular Cellular Biology I

  Fall, 農学部
• From Apr. 2015, To Mar. 2016

  Applied Life Sciences III

  Spring, 農学研究科
• From Apr. 2015, To Mar. 2016

  Experimental Course of Cellular Biochemistry1

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Experimental Course of Cellular Biochemistry

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Cellular Biochemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Cellular Biochemistry Seminar

  Year-long, 農学研究科
• From Apr. 2015, To Mar. 2016

  Cellular Biochemistry

  Spring, 農学研究科
• From Apr. 2016, To Mar. 2017

  Laboratory Course in Molecular Biology

  Fall, 農学部
• From Apr. 2016, To Mar. 2017

  Molecular Cellular Biology I

  Fall, 農学部
• From Apr. 2016, To Mar. 2017

  Applied Life Sciences III

  Spring, 農学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course of Cellular Biochemistry1

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course of Cellular Biochemistry2

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course of Cellular Biochemistry

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Cellular Biochemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Cellular Biochemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Cellular Biochemistry Seminar

  Year-long, 農学研究科
• From Apr. 2016, To Mar. 2017

  Cellular Biochemistry

  Spring, 農学研究科
• From Apr. 2017, To Mar. 2018

  Laboratory Course in Molecular Biology

  Fall, 農学部
• From Apr. 2017, To Mar. 2018

  Molecular Cellular Biology I

  Fall, 農学部
• From Apr. 2017, To Mar. 2018

  Applied Life Sciences III

  Spring, 農学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course of Cellular Biochemistry1

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course of Cellular Biochemistry2

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course of Cellular Biochemistry

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Cellular Biochemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Cellular Biochemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Cellular Biochemistry Seminar

  Year-long, 農学研究科
• From Apr. 2017, To Mar. 2018

  Cellular Biochemistry

  Spring, 農学研究科
• From Apr. 2018, To Mar. 2019

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Laboratory Course in Molecular Biology

  Fall, 農学部
• From Apr. 2018, To Mar. 2019

  Molecular Cellular Biology I

  Fall, 農学部
• From Apr. 2018, To Mar. 2019

  Applied Life Sciences III

  Spring, 全学共通科目
• From Apr. 2018, To Mar. 2019

  Applied Life Sciences III

  Spring, 農学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course of Cellular Biochemistry1

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course of Cellular Biochemistry2

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Cellular Biochemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Cellular Biochemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2018, To Mar. 2019

  Cellular Biochemistry

  Spring, 農学研究科
• From Apr. 2019, To Mar. 2020

  Molecular BiologyII

  Fall, 農学部
• From Apr. 2019, To Mar. 2020

  Molecular Cellular Biology I

  Fall, 農学部
• From Apr. 2019, To Mar. 2020

  Applied Life Sciences III

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Applied Life Sciences III

  Spring, 農学研究科
• From Apr. 2019, To Mar. 2020

  Introduction to Applied Life Science III

  Fall, 農学部
• From Apr. 2019, To Mar. 2020

  Experimental Course of Cellular Biochemistry1

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course of Cellular Biochemistry2

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Cellular Biochemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Cellular Biochemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2019, To Mar. 2020

  Cellular Biochemistry

  Spring, 農学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Applied Biochemistry

  Fall, 農学研究科
• From Apr. 2020, To Mar. 2021

  Molecular BiologyII

  Fall, 農学部
• From Apr. 2020, To Mar. 2021

  Molecular Cellular Biology I

  Fall, 農学部
• From Apr. 2020, To Mar. 2021

  Applied Life Sciences III

  Spring, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Applied Life Sciences III

  Spring, 農学研究科
• From Apr. 2020, To Mar. 2021

  Introduction to Applied Life Science III

  Fall, 農学部
• From Apr. 2020, To Mar. 2021

  Experimental Course of Cellular Biochemistry1

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course of Cellular Biochemistry2

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Cellular Biochemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Cellular Biochemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2020, To Mar. 2021

  Cellular Biochemistry

  Spring, 農学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Applied Biochemistry

  Fall, 農学研究科
• From Apr. 2021, To Mar. 2022

  Molecular Cellular Biology I

  Fall, 農学部
• From Apr. 2021, To Mar. 2022

  Scientific English

  Spring, 農学部
• From Apr. 2021, To Mar. 2022

  Applied Life Sciences III

  Spring, 農学研究科
• From Apr. 2021, To Mar. 2022

  Introduction to Applied Life Science III

  Fall, 農学部
• From Apr. 2021, To Mar. 2022

  Structural Biology

  Spring, 農学部
• From Apr. 2021, To Mar. 2022

  Experimental Course of Cellular Biochemistry1

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course of Cellular Biochemistry2

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Cellular Biochemistry Seminar1

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Cellular Biochemistry Seminar2

  Year-long, 農学研究科
• From Apr. 2021, To Mar. 2022

  Cellular Biochemistry

  Spring, 農学研究科

Participation in PhD Defense

• ヒト脂質輸送体ABCA1のコレステロール認識機構に関する生化学研究

  SAKATA KAZUKI, Graduate School of Agriculture, Chief Examiner

  25 Mar. 2024
• 接着斑細胞膜の脂質組成ならびに生理的意義の解明

  TACHIBANA HIROSHI, Graduate School of Agriculture, Chief Examiner

  25 Mar. 2024
• Breeding of useful bacterial strains in food industry based on the analysis of metabolic systems and phage susceptibilities

  WAKINAKA TAKURA, Graduate School of Agriculture, Sub-chief Examiner

  25 Mar. 2024
• Molecular mechanism of concentration-regulated methanol induction and its signaling pathway in methylotrophic yeasts

  INOUE KOICHI, Graduate School of Agriculture, Sub-chief Examiner

  23 Mar. 2023
• Studies on a Bioactive Substance for Epidermal Barrier Improvement Derived from Fermented Barley Extract

  MARUOKA NARUYUKI, Graduate School of Agriculture, Sub-chief Examiner

  24 Nov. 2021
• ABC蛋白質のATP共役機構と新規生理的役割に関する研究

  FUTAMATA RYOTA, Graduate School of Agriculture, Chief Examiner

  23 Mar. 2022

Administration

School management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2026

  設備整備・共用促進委員会 委員
• From 01 Apr. 2020, To 31 Mar. 2022

  大学評価委員会 委員

Faculty management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2026

  情報セキュリティ・システム委員会　委員
• From 01 Apr. 2024, To 31 Mar. 2026

  環境・安全・衛生委員会　委員長
• From 01 Apr. 2024, To 31 Mar. 2026

  建築委員会
• From 01 Apr. 2023, To 31 Mar. 2026

  将来構想検討委員会　委員
• From 01 Apr. 2023, To 31 Mar. 2024

  環境・安全・衛生委員会　委員長
• From 2023, To 31 Mar. 2026

  兼業審査委員会　委員
• From 01 Apr. 2023, To 31 Mar. 2026

  制度・組織等検討委員会　委員長
• From 01 Apr. 2023, To 31 Mar. 2026

  副研究科長
• From 01 Apr. 2022, To 31 Mar. 2026

  評価委員会　委員
• From 01 Apr. 2022, To 31 Mar. 2023

  応用生命科学科長
• From 01 Apr. 2015, To 31 Mar. 2019

  図書委員会　委員
• From 01 Apr. 2005, To 31 Mar. 2021

  動物実験委員会　委員
• From 01 Apr. 2020, To 31 Mar. 2023

  研究科教務委員会　委員