Basic Information

Faculty

• Faculty of Engineering

Concurrent Affiliation

• Center for the Promotion of Interdisciplinary Education and Research (C-PiER), スーパーグローバルコース 化学系ユニット

Professional Memberships

• From Feb. 2016

  Protein Science Society of Japan
• From Jun. 2015

  The Biophysical Society of Japan
• From Apr. 2014

  The Nuclear Magnetic Resonance Society of Japan

Academic Degree

• M.S. in Engineering(Kyoto University)
• Ph.D. in Engineering(Kyoto University)

Academic Resume (Graduate Schools)

• Kyoto University, Graduate School of Engineering, Department of Molecular Engineering, 修了
• Kyoto University, Graduate School of Engineering, Department of Molecular Engineering, 修了

Academic Resume (Undergraduate School/Majors)

• Kyoto University, Faculty of Engineering, Undergraduate School of Industrial Chemistry, 卒業

High School

• High School

  滋賀県立膳所高校

Research History

• From Sep. 2014, To Present

  Kyoto University, Department of Engineering, Assistant Professor
• From Apr. 2014, To Aug. 2014

  Graduate School of Engineering, Kyoto University, Researcher

Profile

• Profile

  My current research interests are focused on understanding the molecular principles underlying abnormal protein aggregation associated with neurodegenerative diseases. My education mission is to enable students to acquire research knowledges and techniques.

Language of Instruction

• English

ID,URL

• ORCID ID

  0000-0002-7672-2136

• J-Global ID

  201401042418932689

• External link

  http://www.moleng.kyoto-u.ac.jp/~moleng_01/

Website(s) (URL(s))

• http://www.moleng.kyoto-u.ac.jp/~moleng_01/index.htm

researchmap URL

• https://researchmap.jp/7000010378

Research

Research Topics, Overview of the research

• Research Topics

  Elucidation of the mechanism of ubiquitin-positive inclusion formation in neurodegenerative diseases

• Overview of the research

  Ubiquitin is often found in inclusion bodies associated with neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases. We have revealed that polymerization of ubiquitin causes its aggregation and that the aggregates are selectively degraded in living cells. Now we study the molecular mechanism of aggregate formation of polyubiquitin chains.

Research Interests

• Biophysics
• Structural Biology
• Rheo-NMR
• Ubiquitin

Research Areas

• Life sciences, Biophysics
• Life sciences, Structural biochemistry
• Life sciences, Molecular biology
• Natural sciences, Bio-, chemical, and soft-matter physics
• Life sciences, Cell biology

Papers

• A fast and simple automated multi-step protein purification method for ÄKTA go systems

  Daichi Morimoto; Erik Walinda

  Protein Expression and Purification, Nov. 2024, Peer-reviewed, Lead author, Corresponding author

  
• Cyclization of ubiquitin chains reinforces their recognition by ZNF216

  Tomoki Sorada; Erik Walinda; Daichi Morimoto

  FEBS Letters, 09 Jun. 2024, Peer-reviewed, Last author, Corresponding author

  
• Molecular recognition and deubiquitination of cyclic K48-linked ubiquitin chains by OTUB1 (vol 562, pg 94, 2021)

  T Sorada; D Morimoto; E Walinda; K Sugase

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jun. 2023, Peer-reviewed

  
• 混雑環境がタンパク質の構造揺らぎと異常凝集体形成に影響を与える

  森本 大智; Erik Walinda; 菅瀬 謙治

  細胞, Mar. 2023

  
• An integrated approach of NMR experiments and MD simulations visualizes structural dynamics of a cyclic multi‐domain protein

  Tomoki Sorada; Erik Walinda; Masahiro Shirakawa; Kenji Sugase; Daichi Morimoto

  Protein Science, 25 Aug. 2023, Peer-reviewed, Corresponding author

  
• Conformational Fluctuations and Induced Orientation of a Protein, Its Solvation Shell, and Bulk Water in Weak Non-Unfolding External Electric Fields

  Yusuke Shuto; Erik Walinda; Daichi Morimoto; Kenji Sugase

  The Journal of Physical Chemistry B, 16 Aug. 2023, Peer-reviewed

  Access this paper :

  
• Solution structure of the HOIL-1L NZF domain reveals a conformational switch regulating linear ubiquitin affinity

  Erik Walinda; Kenji Sugase; Naoki Ishii; Masahiro Shirakawa; Kazuhiro Iwai; Daichi Morimoto

  Journal of Biological Chemistry, Aug. 2023, Peer-reviewed, Corresponding author

  
• Rheo‐NMR Spectroscopy for Cryogenic‐Probe‐Equipped NMR Instruments to Monitor Protein Aggregation

  Daichi Morimoto; Erik Walinda; Akihiko Yamamoto; Ulrich Scheler; Kenji Sugase

  Current Protocols, Dec. 2022, Peer-reviewed, Lead author

  
• Counter-flow phenomena studied by nuclear magnetic resonance (NMR) velocimetry and flow simulations

  Benjamin Kohn; Erik Walinda; Kenji Sugase; Daichi Morimoto; Ulrich Scheler

  Physics of Fluids, Jul. 2022, Peer-reviewed

  
• Expression, solubility monitoring, and purification of the co-folded LUBAC LTM domain by structure-guided tandem folding in autoinducing cultures

  Erik Walinda; Daichi Morimoto; Tomoki Sorada; Kazuhiro Iwai; Kenji Sugase

  Protein Expression and Purification, Nov. 2021, Peer-reviewed

  
• Backbone resonance assignments of the A2 domain of mouse von Willebrand factor

  Daichi Morimoto; Masanori Osugi; Yutaka Mahana; Erik Walinda; Masahiro Shirakawa; Kenji Sugase

  Biomolecular NMR Assignments, Oct. 2021, Peer-reviewed, Lead author

  
• Effects of weak nonspecific interactions with ATP on proteins

  Mayu Nishizawa; Erik Walinda; Daichi Morimoto; Benjamin Kohn; Ulrich Scheler; Masahiro Shirakawa; Kenji Sugase

  Journal of the American Chemical Society, 11 Aug. 2021, Peer-reviewed

  
• Multiple-state monitoring of SOD1 amyloid formation at single-residue resolution by Rheo-NMR spectroscopy

  Naoto Iwakawa; Daichi Morimoto; Erik Walinda; Masahiro Shirakawa; Kenji Sugase

  Journal of the American Chemical Society, 21 Jul. 2021, Peer-reviewed

  
• Molecular recognition and deubiquitination of cyclic K48-linked ubiquitin chains by OTUB1

  Tomoki Sorada; Daichi Morimoto; Erik Walinda; Kenji Sugase

  Biochemical and Biophysical Research Communications, Jul. 2021, Peer-reviewed, Corresponding author

  
• Transient Diffusive Interactions with a Protein Crowder Affect Aggregation Processes of Superoxide Dismutase 1 β-Barrel

  Naoto Iwakawa; Daichi Morimoto; Erik Walinda; Sarah Leeb; Masahiro Shirakawa; Jens Danielsson; Kenji Sugase

  The Journal of Physical Chemistry B, Mar. 2021, Peer-reviewed

  
• Structural Dynamic Heterogeneity of Polyubiquitin Subunits Affects Phosphorylation Susceptibility

  Daichi Morimoto; Erik Walinda; Shingo Takashima; Mayu Nishizawa; Kazuhiro Iwai; Masahiro Shirakawa; Kenji Sugase

  Biochemistry, 02 Mar. 2021, Peer-reviewed, Lead author

  
• Rigorous analysis of the interaction between proteins and low water-solubility drugs by qNMR-aided NMR titration experiments

  Takuya Hirakawa; Erik Walinda; Daichi Morimoto; Kenji Sugase

  Physical Chemistry Chemical Physics, 2021, Peer-reviewed

  
• Quantitative monitoring of ubiquitination/deubiquitination reaction cycles by 18O-incorporation

  Yuka Tanaka; Daichi Morimoto; Erik Walinda; Kenji Sugase; Masahiro Shirakawa

  Biochemical and Biophysical Research Communications, Aug. 2020, Peer-reviewed, Corresponding author

  
• Pinpoint analysis of a protein in slow exchange using F1F2-selective ZZ-exchange spectroscopy: assignment and kinetic analysis

  Mayu Nishizawa; Erik Walinda; Daichi Morimoto; Kenji Sugase

  Journal of Biomolecular NMR, May 2020, Peer-reviewed

  
• ユビキチン鎖の鎖長に依存した物性と分解

  Daichi Morimoto

  生化学, 25 Feb. 2020, Invited, Lead author

  
• Topics from special edition 高感度Rheo-NMRによるアミロイド線維化過程のその場観察

  森本 大智; 菅瀬 謙治

  細胞, Oct. 2019, Peer-reviewed

  
• Visualizing protein motion in Couette flow by all-atom molecular dynamics

  Daichi Morimoto

  Biochimica et Biophysica Acta (BBA) - General Subjects, Jun. 2019, Peer-reviewed

  
• Backbone and side-chain resonance assignments of the methyl-CpG-binding domain of MBD6 from Arabidopsis thaliana

  Naoto Iwakawa; Yutaka Mahana; Arina Ono; Izuru Ohki; Erik Walinda; Daichi Morimoto; Kenji Sugase; Masahiro Shirakawa

  Biomolecular NMR Assignments, 21 Apr. 2019, Peer-reviewed

  
• NMR resonance assignments of the NZF domain of mouse HOIL-1L free and bound to linear di-ubiquitin

  Naoki Ishii; Erik Walinda; Naoto Iwakawa; Daichi Morimoto; Kazuhiro Iwai; Kenji Sugase; Masahiro Shirakawa

  Biomolecular NMR Assignments, 19 Apr. 2019, Peer-reviewed

  
• Isolation and characterization of a minimal building block of polyubiquitin fibrils

  Daichi Morimoto; Erik Walinda; Mayo Shinke; Kenji Sugase; Masahiro Shirakawa

  Scientific Reports, 09 Feb. 2018, Peer-reviewed, Lead author

  
• Overview of Relaxation Dispersion NMR Spectroscopy to Study Protein Dynamics and Protein-Ligand Interactions

  Erik Walinda; Daichi Morimoto; Kenji Sugase

  Current Protocols in Protein Science, Apr. 2018, Peer-reviewed

  
• Hydrogen-deuterium exchange profiles of polyubiquitin fibrils

  Daichi Morimoto; Ryo Nishizawa; Erik Walinda; Shingo Takashima; Kenji Sugase; Masahiro Shirakawa

  Polymers, 27 Feb. 2018, Peer-reviewed, Lead author

  Access this paper :

  
• Resolving biomolecular motion and interactions by R2 and R1ρ relaxation dispersion NMR

  Erik Walinda; Daichi Morimoto; Kenji Sugase

  Methods, 2018, Peer-reviewed

  Access this paper :

  
• High-Sensitivity Rheo-NMR Spectroscopy for Protein Studies

  Daichi Morimoto; Erik Walinda; Naoto Iwakawa; Mayu Nishizawa; Yasushi Kawata; Akihiko Yamamoto; Masahiro Shirakawa; Ulrich Scheler; Kenji Sugase

  Analytical Chemistry, 18 Jul. 2017, Peer-reviewed, Lead author

  
• 神経変性疾患の脳内異常タンパク質凝集体形成機構解明

  森本 大智

  上原記念生命科学財団研究報告集, Jan. 2017, Lead author

  
• Practical considerations for investigation of protein conformational dynamics by ¹⁵N R 1ρ relaxation dispersion

  Walinda, E.; Morimoto, D.; Shirakawa, M.; Sugase, K.

  Journal of Biomolecular NMR, 2017, Peer-reviewed

  
• Backbone resonance assignments of monomeric SOD1 in dilute and crowded environments

  Iwakawa, N.; Morimoto, D.; Walinda, E.; Sugase, K.; Shirakawa, M.

  Biomolecular NMR Assignments, 2017, Peer-reviewed, Lead author

  
• Biological and physicochemical functions of ubiquitylation revealed by synthetic chemistry approaches

  Morimoto, D.; Walinda, E.; Sugase, K.; Shirakawa, M.

  International Journal of Molecular Sciences, 2017, Peer-reviewed, Lead author

  Access this paper :

  
• F1F2-selective NMR spectroscopy

  Walinda, E.; Morimoto, D.; Shirakawa, M.; Sugase, K.

  Journal of Biomolecular NMR, May 2017, Peer-reviewed

  
• Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance

  Ishiyama, S.; Nishiyama, A.; Saeki, Y.; Moritsugu, K.; Morimoto, D.; Yamaguchi, L.; Arai, N.; Matsumura, R.; Kawakami, T.; Mishima, Y.; Hojo, H.; Shimamura, S.; Ishikawa, F.; Tajima, S.; Tanaka, K.; Ariyoshi, M.; Shirakawa, M.; Ikeguchi, M.; Kidera, A.; Suetake, I.; Arita, K.; Nakanishi, M.

  Molecular Cell, 2017, Peer-reviewed

  
• Real-time observation of the interaction between thioflavin T and an amyloid protein by using high-sensitivity Rheo-NMR

  Iwakawa, N.; Morimoto, D.; Walinda, E.; Kawata, Y.; Shirakawa, M.; Sugase, K.

  International Journal of Molecular Sciences, 2017, Peer-reviewed

  Access this paper :

  
• Dual function of phosphoubiquitin in E3 activation of parkin

  Erik Walinda; Daichi Morimoto; Kenji Sugase; Masahiro Shirakawa

  Journal of Biological Chemistry, 05 Aug. 2016, Peer-reviewed

  
• The evolving world of ubiquitin: Transformed polyubiquitin chains

  Daichi Morimoto; Masahiro Shirakawa

  Biomolecular Concepts, 01 Jun. 2016, Peer-reviewed, Lead author

  
• Efficient identification and analysis of chemical exchange in biomolecules by R1ρ relaxation dispersion with Amaterasu

  Walinda, E.; Morimoto, D.; Nishizawa, M.; Shirakawa, M.; Sugase, K.

  Bioinformatics, 2016, Peer-reviewed

  
• Ubiquitylation Directly Induces Fold Destabilization of Proteins

  Morimoto, D.; Walinda, E.; Fukada, H.; Sugase, K.; Shirakawa, M.

  Scientific Reports, 2016, Peer-reviewed, Lead author

  Access this paper :

  
• Novel Physicochemical Properties of Ubiquitylation

  Daichi MORIMOTO

  Seibutsu Butsuri, 2016, Invited, Lead author

  
• The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates

  Morimoto, D.; Walinda, E.; Fukada, H.; Sou, Y.-S.; Kageyama, S.; Hoshino, M.; Fujii, T.; Tsuchiya, H.; Saeki, Y.; Arita, K.; Ariyoshi, M.; Tochio, H.; Iwai, K.; Namba, K.; Komatsu, M.; Tanaka, K.; Shirakawa, M.

  Nature Communications, 2015, Peer-reviewed, Lead author

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• Non-invasive analysis of proteins in living cells using nmr spectroscopy

  Tochio, H.; Murayama, S.; Inomata, K.; Morimoto, D.; Ohno, A.; Shirakawaa, M.

  Yakugaku Zasshi, 2015, Peer-reviewed

  
• Solution structure of the ubiquitin-associated (UBA) domain of human autophagy receptor NBR1 and its interaction with ubiquitin and polyubiquitin

  Walinda, E.; Morimoto, D.; Sugase, K.; Konuma, T.; Tochio, H.; Shirakawa, M.

  Journal of Biological Chemistry, 2014, Peer-reviewed

  
• Crystal structure of the ubiquitin-associated (UBA) domain of p62 and its interaction with ubiquitin

  Isogai, S.; Morimoto, D.; Arita, K.; Unzai, S.; Tenno, T.; Hasegawa, J.; Sou, Y.-S.; Komatsu, M.; Tanaka, K.; Shirakawa, M.; Tochio, H.

  Journal of Biological Chemistry, 2011, Peer-reviewed

  
• Purification, crystallization and preliminary crystallographic studies of Lys48-linked polyubiquitin chains

  Morimoto, D.; Isogai, S.; Tenno, T.; Tochio, H.; Shirakawa, M.; Ariyoshi, M.

  Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 2010, Peer-reviewed, Lead author

  
• Structural Insights into Methylated DNA Recognition by the Methyl-CpG Binding Domain of MBD6 from Arabidopsis thaliana

  Yutaka Mahana; Izuru Ohki; Erik Walinda; Daichi Morimoto; Kenji Sugase; Masahiro Shirakawa

  ACS Omega, 01 Feb. 2022, Peer-reviewed

  Access this paper :

  

Misc.

• シロイヌナズナ由来のタンパク質MBD6によるメチル化DNA認識の構造基盤

  真鼻裕; 岩川直都; 尾野有菜; 大木出; ヴァリンダ エリック; 森本大智; 菅瀬謙治; 白川昌宏

  日本細胞生物学会大会(Web), 2019

  
• シロイヌナズナのDNA結合タンパク質MBD6の構造解析

  真鼻裕; 岩川直都; 尾野有菜; 大木出; WALINDA Erik; 森本大智; 菅瀬謙治; 白川昌宏

  日本分子生物学会年会プログラム・要旨集(Web), 2018

  
• ユビキチン化に伴うタンパク質構造不安定化

  森本大智; WALINDA Erik; 菅瀬謙治; 深田はるみ; 曽友深; 蔭山俊; 蔭山俊; 星野大; 藤井高志; 土屋光; 佐伯泰; 有田恭平; 有吉眞理子; 杤尾豪人; 岩井一宏; 難波啓一; 難波啓一; 小松雅明; 小松雅明; 田中啓二; 白川昌宏

  Abstracts. Annual Meeting of the NMR Society of Japan, 2014

  
• タンパク質の構造破綻とその関連疾患 物性化学から臨床まで 細胞内におけるユビキチン陽性タンパク質凝集体の形成機構の解明

  森本 大智; ヴァリンダ・エリック; 深田 はるみ; 菅瀬 謙治; 蔭山 俊; 星野 大; 難波 啓一; 小松 雅明; 田中 啓二; 白川 昌宏

  日本生化学会大会プログラム・講演要旨集, Sep. 2016

  
• p62 UBAドメインのユビキチン認識機構の構造学的研究

  森本 大智; 磯貝 信; 阿部 翔吾; 有田 恭平; 雲財 悟; 天野 剛志; 有吉 眞理子; 杤尾 豪人; 小松 雅明; 田中 啓二; 白川 昌宏

  日本生化学会大会プログラム・講演要旨集, Sep. 2009

  
• Crystal structure of p62 ubiquitin associated (UBA) domain

  Shin Isogai; Takeshi Tenno; Morimoto Daichi; Abe Shogo; Tochio Hidehito; Arita Kyouhei; Ariyoshi Mariko; Tanaka Keiji; Shirakawa Masahiro

  ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2008

  

Presentations

• Elucidation of formation mechanisms and development of discrimination methods for abnormal protein aggregates with distinct morphologies using rheology NMR techniques

  Daichi Morimoto; Erik Walinda; Masahiro Shirakawa

  63rd Annual Meeting of the Nuclear Magnetic Resonance Society of Japan, 01 Nov. 2024

  
• 生体内の流れによるタンパク質の構造破壊

  森本大智

  第1回CCC講演会, 15 Dec. 2023, Invited

  
• 生体内環境がタンパク質凝集に与える影響

  森本大智

  第8回生体分子凝縮体勉強会, 08 Dec. 2023, Invited

  
• Elucidation of structural dynamics of a cyclic multi-domain protein by an integrated approach of NMR relaxation experiments and coarse-grained MD simulations

  Daichi Morimoto; Tomoki Sorada; Erik Walinda; Masahiro Shirakawa; Kenji Sugase

  第62回NMR討論会, 07 Nov. 2023

  
• Atomic-level elucidation of amyloid formation mechanism by NMR spectroscopy

  森本大智

  第61回NMR討論会, 09 Nov. 2022, Invited

  
• レオロジーNMR法によるSOD1アミロイド形成の多状態その場観察

  森本大智

  第60回日本生物物理学会年会, 23 Sep. 2022, Invited

  
• 溶液NMR法を用いたタンパク質のその場観察

  森本大智

  第22回若手NMR研究会, 23 Sep. 2022, Invited

  
• Multiple-state monitoring of amyloid formation at atomic resolution by Rheology NMR spectroscopy

  森本大智

  第22回日本蛋白質科学会年会, 08 Jun. 2022, Invited

  
• 細胞内タンパク質加水分解反応による酸素安定同位体取込みの定量的質量分析

  森本大智

  第5回京都生体質量分析研究会国際シンポジウム, 28 Jan. 2022, Invited

  
• Fibrillar protein aggregate formation of poly-ubiquitin revealed by physical property analysis

  Morimoto, Daichi

  The 92nd annual meeting of the Japanese biochemical society, 18 Sep. 2019, Invited

  
• Amyloid formation of poly-ubiquitin chains investigated by biological rheo-NMR spectroscopy

  Morimoto, Daichi

  EUROISMAR 2019, 25 Aug. 2019

  
• バイオレオロジーNMR法の開発と応用

  森本 大智

  第20回若手NMR研究会, 02 Aug. 2019, Invited

  
• Amyloid fibril formation of poly-ubiquitin revealed by physical property analysis

  Morimoto, Daichi

  Joint Annual Meeting of 71st JSCB and 19th PSSJ, 24 Jun. 2019, Invited

  
• Development of high-sensitivity Rheo-NMR spectroscopy

  Morimoto, Daichi

  The 19th Young NMR Scientist Meeting, 05 Aug. 2018, Invited

  
• Atomic-level structural characterization of amyloid formation by using Rheo-NMR spectroscopy

  Morimoto, Daichi

  The 18th Annual Meeting of the Protein Science Society of Japan, 28 Jun. 2018, Invited

  
• 高感度レオロジーNMRの開発と応用

  森本 大智

  第55回NMR討論会, Nov. 2016

  
• Ubiquitylation-induced protein aggregation

  Daichi Morimoto

  The 54th Annual Meeting of the Biophysical Society of Japan, 26 Nov. 2016, Invited

  
• 細胞内におけるユビキチン陽性タンパク質凝集体の形成機構の解明

  森本 大智

  第89回生化学会大会, 25 Sep. 2016, Invited

  
• ユビキチン化、SUMO化によるタンパク質の立体構造変換を介した機能制御

  森本 大智

  第371回CBI学会講演会, 22 Apr. 2016, Invited

  
• 細胞内凝集体形成に関与する蛋白質の構造揺らぎ

  森本 大智

  シンポジウム「細胞環境における蛋白質の動態解析のためのNMRおよび計算科学的アプローチ」, 28 Mar. 2016, Invited

  
• Novel physicochemical properties of ubiquitylation

  Daichi Morimoto

  The 53rd Annual Meeting of the Biophysical Society of Japan, Sep. 2015

  
• Novel physicochemical properties of polyubiquitin chains

  Daichi Morimoto

  FASEB Science Research Conference: Molecular Mechanisms and Physiological Consequences of Protein Aggregation, Jun. 2015

  
• Novel chain-length-dependent properties of polyubiquitin chains

  Daichi Morimoto

  The 37th Annual Meeting Of The Molecular Biology Society of Japan, Nov. 2014

  
• Folding destabilization of a protein by ubiquitylation

  Daichi Morimoto

  The 53th Annual Meeting of the NMR Society of Japan, Nov. 2014

  
• Ubiquitylation directly induces folding destabilization of substrate proteins

  Daichi Morimoto

  ICMRBS XXV, Aug. 2014

  
• Comparison of Structural Dynamics of Polyubiquitin Chain with that of monomer

  Daichi Morimoto

  ICMRBS XXIV, Aug. 2012

  

Books and Other Publications

• In situ observation of protein aggregation by Rheo-NMR spectroscopy

  森本 大智, Single work

  Low Temperature Materials Sciences, Oct. 2024

  
• NMR によるアミロイド形成の原子レベル機構解明

  森本 大智, Single work

  日本核磁気共鳴学会, Aug. 2023

  
• タンパク質の構造解析手法とIn silicoスクリーニングへの応用事例

  森本大智; 菅瀬謙治, Joint work, 第3節 タンパク質を多角的に捉えるNMR測定法

  技術情報協会, Jul. 2023

  Find Kyoto University's collection of books :

  
• 高感度Rheo-NMRによるアミロイド線維化過程のその場観察

  森本 大智; 菅瀬 謙治, Joint work

  北隆館, Oct. 2019

  
• NMRによる有機材料分析とその試料前処理、データ解釈

  森本 大智; 菅瀬 謙治, Joint work

  技術情報協会, Sep. 2021

  Find Kyoto University's collection of books :

  
• 生体分子レオロジーNMRの開発と応用

  Morimoto, Daichi; Sugase, Kenji, Joint work

  日本核磁気共鳴学会, Oct. 2019

  
• タンパク質の翻訳後修飾を操る

  Daichi Morimoto, Single work

  KAGAKUDOJIN, Aug. 2019, Not refereed

  
• Novel properties of ubiquitin: Chain-length dependent aggregation propensity

  Daichi Morimoto; Shirakawa Masahiro, Joint work

  Ishiyaku Publishers, Mar. 2016, Not refereed

  

Industrial Property Rights

• 特許7255801, 特開2020-204481, 特願2019-111013, 剪断流を発生させる器具

  菅瀬謙治; 森本大智; 保科好秀

  

Awards

• 09 Jun. 2022

  日本蛋白質科学会若手奨励賞
• 09 Nov. 2022

  日本核磁器共鳴学会進捗賞
• 13 Sep. 2015

  The Biophysical Society of Japan, Early Career Presentation Award
• 05 Nov. 2014

  The Nuclear Magnetic Resonance Society of Japan, Young scientist travel award
• 05 Nov. 2014

  The Nuclear Magnetic Resonance Society of Japan, JEOL RESONANCE award at the 53rd Annual Meeting of the NMR Society of Japan
• 12 Dec. 2013

  New aspect of ubiquitin system: its enormous roles in protein regulation, Oral presentation award at the new aspect of the ubiquitin system conference
• 12 Aug. 2011

  Graduate School of Engineering, Kyoto University, Mazume Research Encouragement Prize

Media Coverage

• KyotoU Future Commons

  Kyoto University, Kyoto University, Oct. 2024, Internet

  
• 京都大学等明确ATP抑制蛋白质凝聚的机制，为预防神经退行性疾病开辟道路

  JST, 14 Sep. 2021, Internet

  
• ＡＴＰがタンパク質凝集を抑制 京大など仕組み解明

  科学新聞, 20 Aug. 2021, Paper

  
• ＡＴＰ、たんぱく質のアミロイド線維化を抑える 京大など解明

  日刊工業新聞, 13 Aug. 2021, Paper

  
• 凝集抑制剤としてのATPの機能を解明 －ATPが神経変性疾患の発症を抑制する－

  京都大学, 03 Aug. 2021, Internet

  
• 京大、アミロイド線維化 高分解能で過程観察 発症の仕組み解明へ

  日刊工業新聞, 20 Jul. 2021, Paper

  
• 高分解能で見るアミロイド線維形成 －アルツハイマー病やALSなどの発症機構理解のための新たな研究手法－

  京都大学, 09 Jul. 2021, Internet

  
• 京都大学桂図書館 研究シーズ

  京都大学桂図書館, 研究シーズ, May 2021, Internet

  
• ポリユビキチン鎖のアミロイド様線維形成を発見 －神経変性疾患における脳内異常タンパク質凝集の形成機構解明に期待－

  京都大学, 21 Jan. 2015, Internet

  

External funds: Kakenhi

• Elucidation of the mechanism of amyloid fibrillation of alpha-synuclein starting from liquid-liquid phase separation

  Grant-in-Aid for Scientific Research (B)

  Basic Section 43040:Biophysics-related

  Kyoto University

  Kenji Sugase

  From 01 Apr. 2021, To 31 Mar. 2024, Project Closed

  液-液相分離;アミロイド線維化;αシヌクレイン;剪断流;Rheo-NMR;アミロイド線維

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02442/
• Elucidation of physical properties and intracellular functions of unanchored atypical ubiquitin chains

  Grant-in-Aid for Early-Career Scientists

  Basic Section 43040:Biophysics-related

  Kyoto University

  Daichi Morimoto

  From 01 Apr. 2020, To 31 Mar. 2023, Project Closed

  ユビキチン;構造ゆらぎ;ATP;環状;NMR;非定型鎖;構造揺らぎ;ユビキチン鎖;非定型ユビキチン鎖;遊離ユビキチン鎖;タンパク質物性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K15757/
• Velocity imaging of turbulence flow using Rheo-NMR

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

  Medium-sized Section 13:Condensed matter physics and related fields

  Kyoto University

  Kenji Sugase

  From 09 Oct. 2018, To 31 Mar. 2022, Project Closed

  Rheo-NMR;速度イメージング;off-center Couette cell;乱流;タンパク質凝集;線維化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18KK0075/
• Analysis of structure and formation mechanism of polyubiquitin fibrils

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Daichi Morimoto

  From 01 Apr. 2016, To 31 Mar. 2020, Project Closed

  ポリユビキチン;アミロイド線維;重水素交換;反応中間体;レオロジーNMR;構造ゆらぎ;流体力学的応力;線維反応中間体;線維重水素交換;ユビキチン;アミロイド;NMR;線維;蛋白質;生物物理

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K18503/
• Elucidation of chain shape-dependent physical properties of polyubiquitin related with stress granule formation

  Grant-in-Aid for Scientific Research (C)

  Basic Section 43040:Biophysics-related

  Kyoto University

  森本 大智

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  ユビキチン;非定型鎖;構造揺らぎ;凝集;線維;物性;ストレス顆粒

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K06168/
• Development of analytical platform for proteins in electric field and its application

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields

  Kyoto University

  菅瀬 謙治

  From 07 Oct. 2022, To 31 Mar. 2026, Granted

  電場;NMR;タンパク質;電気泳動;凝集;分子動力学計算

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KK0098/
• 流れストレスセンサータンパク質の開発

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (II)

  Kyoto University

  森本 大智

  From 01 Apr. 2025, To 31 Mar. 2027, Adopted

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-25H02265/

Education

Teaching subject(s)

• From 01 Apr. 2022, To 31 Mar. 2023

  Molecular Engineering, Adv. VI

  P439, Fall, Graduate School of Engineering, 0.5
• From Apr. 2017, To Mar. 2018

  Molecular Engineering, Adv. VI

  Spring, 工学研究科
• From Apr. 2019, To Mar. 2020

  Molecular Engineering, Adv. VII

  Spring, 工学研究科
• From Apr. 2020, To Mar. 2021

  Biomolecular Function Chemistry

  Spring, 工学研究科
• From Apr. 2021, To Mar. 2022

  Fundamental Chemical Experiments

  Spring, 全学共通科目

Academic, Social Contribution

Committee Memberships

• From Aug. 2016, To Present

  寒剤供給専門小委員会, 京都大学 環境安全保健機構 低温物質管理部門
• From Dec. 2015, To Dec. 2015

  世話人, RRR workshop 2015
• From Oct. 2017, To Present

  編集委員, 蛋白質科学会アーカイブ編集委員会
• From Sep. 2021, To Sep. 2021

  世話人, 第21回若手NMR研究会
• From Dec. 2020, To Dec. 2020

  委員長, 量子生命科学会・第２回大会