Basic Information

Faculty

• Faculty of Agriculture

Professional Memberships

• From Jun. 2023, To Present

  日本農芸化学会
• From 2021, To Present

  日本生物物理学会
• From 2008, To Present

  The Nuclear Magnetic Resonance Society of Japan
• From 2008, To Present

  PROTEIN SCIENCE SOCIETY OF JAPAN

Academic Degree

• Master of Engineering(Yokohama National University)
• Doctor of Engineering (Yokohama National University)

Research History

• From Apr. 2022, To Present

  Kyoto University, Division of Applied Life Sciences, Graduate School of Agriculture, Full Professor
• From Feb. 2015, To Mar. 2022

  Kyoto University, Department of Molecular Engineering, Graduate School of Engineering, Associate Professor
• From Apr. 2018, To Mar. 2019

  Osaka University, Institute for Protein Research, 客員フェロー
• From Jan. 2011, To Jan. 2015

  Suntory Foundation for Life Sciences, Bioorganic Research Institute, NMR Group Leader, Senior Researcher
• From Apr. 2009, To Jan. 2015

  Kobe University, Graduate School of Engineering, Visiting Associate Professor
• From Oct. 2008, To Dec. 2010

  Suntory Bioorganic Research Institute, NMR Group Leader, Senior Researcher
• From Apr. 2008, To Sep. 2008

  Suntory Bioorganic Research Institute, Senior Researcher
• From Apr. 1997, To Mar. 2008

  Suntory Bioorganic Research Institute, Researcher
• From Sep. 2005, To Aug. 2006

  The Scripps Research Institute, Department of Molecular Biology, Senior Research Associate
• From Sep. 2003, To Aug. 2005

  The Scripps Research Institute, Department of Molecular Biology, Research Associate

Language of Instruction

• English
• Japanese

ID,URL

• J-Global ID

  200901097137805725

• External link

  https://researchmap.jp/read0006511/

Website(s) (URL(s))

• https://research.kyoto-u.ac.jp/documentary/d023/
• http://www.tenko.kais.kyoto-u.ac.jp/
• https://researchmap.jp/read0006511/

researchmap URL

• https://researchmap.jp/read0006511

Research

Research Topics, Overview of the research

• Research Topics

  Mechanism of protein aggregation in dynamic solution environments
  Mechanism of protein fibrillation inhibition by food ingredients
  Mechanism of long term memory formation by aggregation-coupled protein translation

• Overview of the research

  The in vivo environment is a dynamic solution environment in which blood flow and the electric field of neurons exist. Recently, it has been shown that certain proteins undergo liquid-liquid phase separation and amyloid fibrillation in response to the dynamic solution environments. Liquid-liquid phase separation and amyloid fibrillation are associated with long-term memory formation and neurodegenerative diseases. I have been studying the mechanisms of liquid-liquid phase separation and amyloid fibrillation that form in response to the dynamic solution environment, and also studying the mechanism of inhibition of amyloid fibrosis by food ingredients.

Research Interests

• E-NMR
• NMR
• Rheo-NMR
• protein aggregation
• Biophysics
• Structural Biology

Papers

• Evolutionary aspects of molecular forms and biological functions of oxytocin family peptides

  Tsuyoshi Kawada; Toshio Sekiguchi; Kenji Sugase; Atsuhiro Kanda; Honoo Satake

  Handbook of Oxytocin Research: Synthesis, Storage and Release, Actions and Drug Forms, Apr. 2009

  
• Optimizing in vitro expression balance of central dogma-related genes using parallel reaction monitoring

  Chisato Nishizawa; Shunsuke Aburaya; Yuishin Kosaka; Kenji Sugase; Wataru Aoki

  Journal of Bioscience and Bioengineering, May 2024, Peer-reviewed

  
• Applications of relaxation dispersion spectroscopy

  Sugase, K.

  Seikagaku, 2008

  
• Structural analysis of 11C, 15N labeled adenosine by solid-state NMR.

  Fujiwara, T.; Sugase, K.; Kainosyo, M.; Ono, A.; Akutsu, H.

  Nucleic acids symposium series, 1995

  
• An integrated approach of NMR experiments and MD simulations visualizes structural dynamics of a cyclic multi‐domain protein

  Tomoki Sorada; Erik Walinda; Masahiro Shirakawa; Kenji Sugase; Daichi Morimoto

  Protein Science, 15 Sep. 2023, Peer-reviewed

  
• Solution structure of the HOIL-1L NZF domain reveals a conformational switch regulating linear ubiquitin affinity

  Erik Walinda; Kenji Sugase; Naoki Ishii; Masahiro Shirakawa; Kazuhiro Iwai; Daichi Morimoto

  Journal of Biological Chemistry, Aug. 2023, Peer-reviewed

  
• Conformational Fluctuations and Induced Orientation of a Protein, Its Solvation Shell, and Bulk Water in Weak Non-Unfolding External Electric Fields

  Yusuke Shuto; Erik Walinda; Daichi Morimoto; Kenji Sugase

  The Journal of Physical Chemistry B, 16 Aug. 2023, Peer-reviewed, Last author, Corresponding author

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• Crowded environments affect structural fluctuations and abnormal aggregation of proteins

  森本大智; Erik Walinda; 菅瀬謙治

  月刊「細胞」, Mar. 2023, Peer-reviewed, Invited, Corresponding author

  
• Rheo‐NMR Spectroscopy for Cryogenic‐Probe‐Equipped NMR Instruments to Monitor Protein Aggregation

  Daichi Morimoto; Erik Walinda; Akihiko Yamamoto; Ulrich Scheler; Kenji Sugase

  Current Protocols, Dec. 2022, Peer-reviewed, Invited

  
• S03A3 Metastable structure detected by relaxation dispersion NMR spectroscopy(Visualising Dynamical Aspects of A Protein Molecule)

  Sugase Kenji; Dyson Jane H.; Wright Peter E.

  Seibutsu Butsuri, 2007

  
• Counter-flow phenomena studied by nuclear magnetic resonance (NMR) velocimetry and flow simulations

  Benjamin Kohn; Erik Walinda; Kenji Sugase; Daichi Morimoto; Ulrich Scheler

  Physics of Fluids, Jul. 2022, Peer-reviewed

  
• 1SB-02 Identification of an allosteric site from the analysis of protein fluctuation using NMR(1SB Exploring design principles of life,The 49th Annual Meeting of the Biophysical Society of Japan)

  Erisa Harada; Masakazu Sugishima; Jiro Harada; Masato Noguchi; Keiichi Fukuyama; Kenji Sugase

  Seibutsu Butsuri, 2011, Last author, Corresponding author

  
• 1H1448 A design strategy of high-energy states of proteins based on high pressure NMR study(Protein: Property 2,The 49th Annual Meeting of the Biophysical Society of Japan)

  Souichiro Kitazawa; Maho Yagi; Kenji Sugase; Koichi Kato; Ryo Kitahara

  Seibutsu Butsuri, 2011

  
• 2P050 1E1435 The effect of structural dynamics of the Human Leucocyte Antigen on the function of cytotoxic T Lymphocyte(The 48th Annual Meeting of the Biophysical Society of Japan)

  Saeko Yanaka; Kenji Sugase; Chihiro Motozono; Takamasa Ueno; Kouhei Tsumoto

  Seibutsu Butsuri, 2010

  
• 1SC0945 Fluctuation and Function of Nuclear Pproteins(1SC Fluctuation and Function of Biomolecules,The 48th Annual Meeting of the Biophysical Society of Japan)

  Kenji Sugase; Erisa Harada

  Seibutsu Butsuri, 2010, Lead author, Corresponding author

  
• Expression, solubility monitoring, and purification of the co-folded LUBAC LTM domain by structure-guided tandem folding in autoinducing cultures.

  Erik Walinda; Daichi Morimoto; Tomoki Sorada; Kazuhiro Iwai; Kenji Sugase

  Protein Expression and Purification, Nov. 2021, Peer-reviewed, Last author

  
• Effects of Weak Nonspecific Interactions with ATP on Proteins.

  Mayu Nishizawa; Erik Walinda; Daichi Morimoto; Benjamin Kohn; Ulrich Scheler; Masahiro Shirakawa; Kenji Sugase

  Journal of the American Chemical Society, 11 Aug. 2021, Peer-reviewed, Corresponding author

  
• Multiple-State Monitoring of SOD1 Amyloid Formation at Single-Residue Resolution by Rheo-NMR Spectroscopy.

  Naoto Iwakawa; Daichi Morimoto; Erik Walinda; Masahiro Shirakawa; Kenji Sugase

  Journal of the American Chemical Society, 21 Jul. 2021, Peer-reviewed, Corresponding author

  
• Backbone resonance assignments of the A2 domain of mouse von Willebrand factor.

  Daichi Morimoto; Masanori Osugi; Yutaka Mahana; Erik Walinda; Masahiro Shirakawa; Kenji Sugase

  Biomolecular NMR assignments, 15 Oct. 2021, Peer-reviewed, Corresponding author

  
• Molecular recognition and deubiquitination of cyclic K48-linked ubiquitin chains by OTUB1

  Tomoki Sorada; Daichi Morimoto; Erik Walinda; Kenji Sugase

  Biochemical and Biophysical Research Communications, 12 Jul. 2021, Peer-reviewed

  
• Glycyrrhizin Derivatives Suppress Cancer Chemoresistance by Inhibiting Progesterone Receptor Membrane Component 1

  Yasuaki Kabe; Ikko Koike; Tatsuya Yamamoto; Miwa Hirai; Ayaka Kanai; Ryogo Furuhata; Hitoshi Tsugawa; Erisa Harada; Kenji Sugase; Kazue Hanadate; Nobuji Yoshikawa; Hiroaki Hayashi; Masanori Noda; Susumu Uchiyama; Hiroki Yamazaki; Hirotoshi Tanaka; Takuya Kobayashi; Hiroshi Handa; Makoto Suematsu

  Cancers, 29 Jun. 2021, Peer-reviewed

  
• Transient Diffusive Interactions with a Protein Crowder Affect Aggregation Processes of Superoxide Dismutase 1 β-Barrel.

  Naoto Iwakawa; Daichi Morimoto; Erik Walinda; Sarah Leeb; Masahiro Shirakawa; Jens Danielsson; Kenji Sugase

  The Journal of Physical Chemistry B, 18 Mar. 2021, Peer-reviewed, Corresponding author

  
• Structural Dynamic Heterogeneity of Polyubiquitin Subunits Affects Phosphorylation Susceptibility

  Daichi Morimoto; Erik Walinda; Shingo Takashima; Mayu Nishizawa; Kazuhiro Iwai; Masahiro Shirakawa; Kenji Sugase

  Biochemistry, 02 Mar. 2021, Peer-reviewed, Corresponding author

  
• Structural dynamics of double-stranded DNA with epigenome modification.

  Ayako Furukawa; Erik Walinda; Kyohei Arita; Kenji Sugase

  Nucleic Acids Research, 25 Jan. 2021, Peer-reviewed, Corresponding author

  
• Rigorous analysis of the interaction between proteins and low water-solubility drugs by qNMR-aided NMR titration experiments

  Takuya Hirakawa; Erik Walinda; Daichi Morimoto; Kenji Sugase

  Physical Chemistry Chemical Physics, 06 Oct. 2021, Peer-reviewed, Corresponding author

  
• Quantitative monitoring of ubiquitination/deubiquitination reaction cycles by 18O-incorporation.

  Yuka Tanaka; Daichi Morimoto; Erik Walinda; Kenji Sugase; Masahiro Shirakawa

  Biochemical and Biophysical Research Communications, 20 Aug. 2020, Peer-reviewed

  
• 剪断力により誘起される相分離の機構解明

  菅瀬 謙治; 関山 直孝; 吉田 紀生

  豊田研究報告 = Reports of Toyota Physical and Chemical Research Institute, May 2020, Invited

  
• Pinpoint analysis of a protein in slow exchange using F1F2-selective ZZ-exchange spectroscopy: assignment and kinetic analysis

  Mayu Nishizawa; Erik Walinda; Daichi Morimoto; Kenji Sugase

  Journal of Biomolecular NMR, May 2020, Peer-reviewed, Corresponding author

  
• Conformational exchange in the potassium channel blocker ShK

  Naoto Iwakawa; Nicola J. Baxter; Dorothy C. C. Wai; Nicholas J. Fowler; Rodrigo A. V. Morales; Kenji Sugase; Raymond S. Norton; Mike P. Williamson

  Scientific Reports, 17 Dec. 2019, Peer-reviewed

  
• Topics from special edition 高感度Rheo-NMRによるアミロイド線維化過程のその場観察

  森本 大智; 菅瀬 謙治

  細胞, Oct. 2019, Invited, Corresponding author

  
• Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody.

  Hiroki Akiba; Hiroko Tamura; Masato Kiyoshi; Saeko Yanaka; Kenji Sugase; Jose M. M. Caaveiro; Kouhei Tsumoto

  Scientific Reports, 29 Oct. 2019, Peer-reviewed

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• Visualizing protein motion in Couette flow by all-atom molecular dynamics.

  Erik Walinda; Daichi Morimoto; Masahiro Shirakawa; Ulrich Scheler; Kenji Sugase

  Biochimica et Biophysica Acta General Subjects, Feb. 2020, Peer-reviewed, Invited, Corresponding author

  
• NMR resonance assignments of the NZF domain of mouse HOIL-1L free and bound to linear di-ubiquitin.

  Naoki Ishii; Erik Walinda; Naoto Iwakawa; Daichi Morimoto; Kazuhiro Iwai; Kenji Sugase; Masahiro Shirakawa

  Biomolecular NMR assignments, Apr. 2019, Peer-reviewed

  
• Backbone and side-chain resonance assignments of the methyl-CpG-binding domain of MBD6 from Arabidopsis thaliana.

  Naoto Iwakawa; Yutaka Mahana; Arina Ono; Izuru Ohki; Erik Walinda; Daichi Morimoto; Kenji Sugase; Masahiro Shirakawa

  Biomolecular NMR assignments, Apr. 2019, Peer-reviewed

  
• Overview of relaxation dispersion NMR spectroscopy to study protein dynamics and protein-ligand interactions.

  Erik Walinda; Daichi Morimoto; Kenji Sugase

  Current Protocol in Protein Science, Apr. 2018, Peer-reviewed, Invited, Corresponding author

  
• Hydrogen-deuterium exchange profiles of polyubiquitin fibrils

  Daichi Morimoto; Ryo Nishizawa; Erik Walinda; Shingo Takashima; Kenji Sugase; Masahiro Shirakawa

  Polymers, 27 Feb. 2018, Peer-reviewed, Invited, Corresponding author

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• Isolation and characterization of a minimal building block of polyubiquitin fibrils.

  Daichi Morimoto; Erik Walinda; Mayo Shinke; Kenji Sugase; Masahiro Shirakawa

  Scientific Reports, 09 Feb. 2018, Peer-reviewed

  
• Resolving biomolecular motion and interactions by R2 and R1ρ relaxation dispersion NMR

  Erik Walinda; Daichi Morimoto; Kenji Sugase

  Methods, 15 Sep. 2018, Peer-reviewed, Invited, Corresponding author

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• Elucidating functional dynamics by R1ρ and R2 relaxation dispersion NMR spectroscopy

  Erik Walinda; Kenji Sugase

  Experimental Approaches of NMR Spectroscopy: Methodology and Application to Life Science and Materials Science, 23 Nov. 2017, Peer-reviewed, Invited, Corresponding author

  
• Real-Time Observation of the Interaction between Thioflavin T and an Amyloid Protein by Using High-Sensitivity Rheo-NMR

  Naoto Iwakawa; Daichi Morimoto; Erik Walinda; Yasushi Kawata; Masahiro Shirakawa; Kenji Sugase

  International Journal of Molecular Sciences, 28 Oct. 2017, Peer-reviewed, Invited, Corresponding author

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• Elucidation of potential sites for antibody engineering by fluctuation editing

  Saeko Yanaka; Yoshitaka Moriwaki; Kouhei Tsumoto; Kenji Sugase

  Scientific Reports, 30 Aug. 2017, Peer-reviewed, Corresponding author

  
• High-Sensitivity Rheo-NMR Spectroscopy for Protein Studies

  Daichi Morimoto; Erik Walinda; Naoto Iwakawa; Mayu Nishizawa; Yasushi Kawata; Akihiko Yamamoto; Masahiro Shirakawa; Ulrich Scheler; Kenji Sugase

  Analytical Chemistry, 18 Jul. 2017, Peer-reviewed, Corresponding author

  
• Biological and Physicochemical Functions of Ubiquitylation Revealed by Synthetic Chemistry Approaches

  Daichi Morimoto; Erik Walinda; Kenji Sugase; Masahiro Shirakawa

  International Journal of Molecular Sciences, 27 May 2017, Peer-reviewed, Invited

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• F1F2-selective NMR spectroscopy

  Erik Walinda; Daichi Morimoto; Masahiro Shirakawa; Kenji Sugase

  Journal of Biomolecular NMR, May 2017, Peer-reviewed, Corresponding author

  
• Exploration of the Conformational Dynamics of Major Histocompatibility Complex Molecules

  Saeko Yanaka; Kenji Sugase

  Frontiers in Immunology, 29 May 2017, Peer-reviewed, Invited, Corresponding author

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• Backbone resonance assignments of monomeric SOD1 in dilute and crowded environments

  Naoto Iwakawa; Daichi Morimoto; Erik Walinda; Kenji Sugase; Masahiro Shirakawa

  Biomolecular NMR Assignments, Apr. 2017, Peer-reviewed

  
• Practical considerations for investigation of protein conformational dynamics by 15N R1ρ relaxation dispersion

  Erik Walinda; Daichi Morimoto; Masahiro Shirakawa; Kenji Sugase

  Journal of Biomolecular NMR, Mar. 2017, Peer-reviewed, Corresponding author

  
• The helical propensity of the extracellular loop is responsible for the substrate specificity of Fe(III)-phytosiderophore transporters

  Erisa Harada; Kenji Sugase; Kosuke Namba; Yoshiko Murata

  FEBS Letters, Dec. 2016, Peer-reviewed

  
• Ubiquitylation Directly Induces Fold Destabilization of Proteins

  Daichi Morimoto; Erik Walinda; Harumi Fukada; Kenji Sugase; Masahiro Shirakawa

  Scientific Reports, 19 Dec. 2016, Peer-reviewed

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• Dynamics of the Extended String-Like Interaction of TFIIE with the p62 Subunit of TFIIH

  Masahiko Okuda; Junichi Higo; Tadashi Komatsu; Tsuyoshi Konuma; Kenji Sugase; Yoshifumi Nishimura

  Biophysical Journal, 06 Sep. 2016, Peer-reviewed

  
• Use of glass capillaries to suppress thermal convection in NMR tubes in diffusion measurements

  Takashi Iwashita; Tsuyoshi Konuma; Erisa Harada; Shoko Mori; Kenji Sugase

  Magnetic Resonance in Chemistry, Sep. 2016, Peer-reviewed

  
• Dual function of phosphoubiquitin in E3 activation of parkin

  Erik Walinda; Daichi Morimoto; Kenji Sugase; Masahiro Shirakawa

  Journal of Biological Chemistry, 05 Aug. 2016, Peer-reviewed

  
• Efficient identification and analysis of chemical exchange in biomolecules by R-1 rho relaxation dispersion with Amaterasu

  Erik Walinda; Daichi Morimoto; Mayu Nishizawa; Masahiro Shirakawa; Kenji Sugase

  Bioinformatics, 15 Aug. 2016, Peer-reviewed, Corresponding author

  
• Quantitative analysis of protein-ligand interactions by NMR

  Ayako Furukawa; Tsuyoshi Konuma; Saeko Yanaka; Kenji Sugase

  Progress in Nuclear Magnetic Resonance Spectroscopy, Aug. 2016, Peer-reviewed, Invited, Corresponding author

  
• Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance

  Yasuaki Kabe; Takanori Nakane; Ikko Koike; Tatsuya Yamamoto; Yuki Sugiura; Erisa Harada; Kenji Sugase; Tatsuro Shimamura; Mitsuyo Ohmura; Kazumi Muraoka; Ayumi Yamamoto; Takeshi Uchida; So Iwata; Yuki Yamaguchi; Elena Krayukhina; Masanori Noda; Hiroshi Handa; Koichiro Ishimori; Susumu Uchiyama; Takuya Kobayashi; Makoto Suematsu

  Nature Communications, Mar. 2016, Peer-reviewed

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• Extracting protein dynamics information from overlapped NMR signals using relaxation dispersion difference NMR spectroscopy

  Tsuyoshi Konuma; Erisa Harada; Kenji Sugase

  Journal of Biomolecular NMR, Dec. 2015, Peer-reviewed, Last author, Corresponding author

  
• Dynamic changes in CCAN organization through CENP-C during cell-cycle progression

  Harsh Nagpal; Tetsuya Hori; Ayako Furukawa; Kenji Sugase; Akihisa Osakabe; Hitoshi Kurumizaka; Tatsuo Fukagawa

  Molecular Biology of the Cell, 01 Nov. 2015, Peer-reviewed

  
• Conformational propensities of intrinsically disordered proteins influence the mechanism of binding and folding

  Munehito Arai; Kenji Sugase; H. Jane Dyson; Peter E. Wright

  Proceedings of the National Academy of Sciences of the United States of America, Aug. 2015, Peer-reviewed

  
• Backbone assignments of the apo and Zn(II) protoporphyrin IX-bound states of the soluble form of rat heme oxygenase-1

  Erisa Harada; Masakazu Sugishima; Jiro Harada; Masato Noguchi; Keiichi Fukuyama; Kenji Sugase

  Biomolecular NMR assignments, Apr. 2015, Peer-reviewed, Last author, Corresponding author

  
• Distal regulation of heme binding of heme oxygenase-1 mediated by conformational fluctuations

  Erisa Harada; Masakazu Sugishima; Jiro Harada; Keiichi Fukuyama; Kenji Sugase

  Biochemistry, 20 Jan. 2015, Peer-reviewed, Last author, Corresponding author

  
• Elucidation of Structural Dynamics Using Relaxation Dispersion NMR Spectroscopy

  菅瀬 謙治

  分光研究, Jan. 2015, Peer-reviewed, Invited, Lead author, Last author, Corresponding author

  
• Revealing the peptide presenting process of human leukocyte antigen through the analysis of fluctuation

  Saeko Yanaka; Takamasa Ueno; Kouhei Tsumoto; Kenji Sugase

  Biophysics, 2015, Peer-reviewed, Invited, Last author, Corresponding author

  
• Solution Structure of the Ubiquitin-associated (UBA) Domain of Human Autophagy Receptor NBR1 and Its Interaction with Ubiquitin and Polyubiquitin

  Erik Walinda; Daichi Morimoto; Kenji Sugase; Tsuyoshi Konuma; Hidehito Tochio; Masahiro Shirakawa

  Journal of Biological Chemistry, 16 May 2014, Peer-reviewed

  
• Solid-state NMR spectra of lipid-anchored proteins under magic angle spinning

  Kaoru Nomura; Erisa Harada; Kenji Sugase; Keiko Shimamoto

  Journal of Physical Chemistry B, 06 Mar. 2014, Peer-reviewed

  
• Quantitative analysis of location- and sequence-dependent deamination by APOBEC3G using real-time NMR spectroscopy.

  Ayako Furukawa; Kenji Sugase; Ryo Morishita; Takashi Nagata; Tsutomu Kodaki; Akifumi Takaori-Kondo; Akihide Ryo; Masato Katahira

  Angewandte Chemie International Edition, 24 Feb. 2014, Peer-reviewed

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• 2P064 The Dynamic stabilization and peptide recognition mechanism of Human Leukocyte Antigen revealed by NMR relaxation dispersion analysis(01C. Protein: Property,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014))

  Yanaka Saeko; Sugase Kenji; Ueno Takamasa; Tsumoto Kouhei

  Seibutsu Butsuri, 2014

  
• 1P035 Conformational Flexibility of the high-mobility group box domain of sox2 and its folding coupled with DNA binding(Protein: Structure & Function,Poster,The 52th Annual Meeting of the Biophysical Society of Japan(BSJ2014))

  Erisa Harada; Tsuyoshi Konuma; Syoko Mori; Kenji Sugase

  Seibutsu Butsuri, 2014, Last author, Corresponding author

  
• Peptide-dependent Conformational Fluctuation Determines the Stability of the Human Leukocyte Antigen Class I Complex

  Saeko Yanaka; Takamasa Ueno; Yi Shi; Jianxun Qi; George F. Gao; Kouhei Tsumoto; Kenji Sugase

  Journal of Biological Chemistry, Aug. 2014, Peer-reviewed, Last author, Corresponding author

  
• 実践relaxation dispersion法

  菅瀬 謙治

  NMR, Oct. 2013, Peer-reviewed, Invited, Lead author, Last author, Corresponding author

  
• Fast and accurate fitting of relaxation dispersion data using the flexible software package GLOVE

  Kenji Sugase; Tsuyoshi Konuma; Jonathan C. Lansing; Peter E. Wright

  Journal of Biomolecular NMR, Jul. 2013, Peer-reviewed, Lead author

  
• Solution structure of the Q41N variant of ubiquitin as a model for the alternatively folded N2 state of ubiquitin

  Soichiro Kitazawa; Tomoshi Kameda; Maho Yagi-Utsumi; Kenji Sugase; Nicola J. Baxter; Koichi Kato; Michael P. Williamson; Ryo Kitahara

  Biochemistry, 19 Mar. 2013, Peer-reviewed

  
• 緩和分散NMR法による動的構造解析

  谷中 冴子、菅瀬 謙治

  蛋白質科学会アーカイブ, 2013, Peer-reviewed, Invited, Last author, Corresponding author

  
• The Monomer–Seed Interaction Mechanism in the Formation of the β2-Microglobulin Amyloid Fibril Clarified by Solution NMR Techniques

  Kotaro Yanagi; Kazumasa Sakurai; Yuichi Yoshimura; Tsuyoshi Konuma; Young-Ho Lee; Kenji Sugase; Takahisa Ikegami; Hironobu Naiki; Yuji Goto

  Journal of Molecular Biology, Sep. 2012, Peer-reviewed

  
• 1PT112 Solution stucture of the alternatively folded state of ubiquitin(The 50th Annual Meeting of the Biophysical Society of Japan)

  Soichiro Kitazawa; Tomoshi Kameda; Maho Yagi; Kenji Sugase; Nicky Baxter; Koichi Kato; Michael P. Williamson; Ryo Kitahara

  Seibutsu Butsuri, 2012

  
• Boosting Protein Dynamics Studies Using Quantitative Nonuniform Sampling NMR Spectroscopy

  Yoh Matsuki; Tsuyoshi Konuma; Toshimichi Fujiwara; Kenji Sugase

  The Journal of Physical Chemistry B, 24 Nov. 2011, Peer-reviewed, Last author, Corresponding author

  
• Elucidating slow binding kinetics of a protein without observable bound resonances by longitudinal relaxation NMR spectroscopy

  Kenji Sugase

  Journal of Biomolecular NMR, Jul. 2011, Peer-reviewed, Lead author, Last author, Corresponding author

  
• Lipopolysaccharide induces raft domain expansion in membrane composed of a phospholipid-cholesterol-sphingomyelin ternary system

  Kaoru Nomura; Masahide Maeda; Kenji Sugase; Shoichi Kusumoto

  Innate Immunity, Jun. 2011

  
• Calcitonin in a protochordate, Ciona intestinalis - the prototype of the vertebrate calcitonin/calcitonin gene-related peptide superfamily

  Toshio Sekiguchi; Nobuo Suzuki; Nobuyuki Fujiwara; Masato Aoyama; Tsuyoshi Kawada; Kenji Sugase; Yoshiko Murata; Yuichi Sasayama; Michio Ogasawara; Honoo Satake

  FEBS Journal, Aug. 2009, Peer-reviewed

  
• Specific transporter for iron(III): Phytosiderophore complex involved in iron uptake by barley roots

  Yoshiko Murata; Emiko Harada; Kenji Sugase; Kosuke Namba; Manabu Horikawa; Jian Feng Ma; Naoki Yamaji; Daisei Ueno; Kyosuke Nomoto; Takashi Iwashita; Shoichi Kusumoto

  Pure and Applied Chemistry, 01 Jan. 2008

  
• New NMR Technique to Probe Invisible Low-Populated States-Development of R2 Relaxation Dispersion Spectroscopy-

  Kenji SUGASE

  Seibutsu Butsuri, 2008, Peer-reviewed, Invited, Lead author, Last author, Corresponding author

  
• Relaxation Dispersion 法の生化学への応用

  菅瀬 謙治

  生化学, Aug. 2008, Peer-reviewed, Invited, Lead author, Last author, Corresponding author

  
• Overexpression of post-translationally modified peptides in Escherichia coli by co-expression with modifying enzymes

  Sugase, K.; L; es, M.A.; Wright, P.E.; Martinez-Yamout, M.

  Protein Expression and Purification, Feb. 2008, Peer-reviewed, Lead author

  
• Tailoring Relaxation Dispersion Experiments for Fast-Associating Protein Complexes

  Kenji Sugase; Jonathan C. Lansing; H. Jane Dyson; Peter E. Wright

  Journal of the American Chemical Society, 01 Nov. 2007, Peer-reviewed, Lead author

  
• Structural element responsible for the Fe(III)-phytosiderophore specific transport by HvYS1 transporter in barley

  Emiko Harada; Kenji Sugase; Kosuke Namba; Takashi Iwashita; Yoshiko Murata

  FEBS Letters, 04 Sep. 2007, Peer-reviewed

  
• Intrinsically disordered protein and encounter complex

  菅瀬 謙治

  Protein, nucleic acid and enzyme, Aug. 2007, Peer-reviewed, Invited, Lead author, Last author, Corresponding author

  
• Solution structure of agelenin, an insecticidal peptide isolated from the spider Agelena opulenta, and its structural similarities to insect-specific calcium channel inhibitors

  Nahoko Yamaji; Kenji Sugase; Terumi Nakajima; Takafumi Miki; Minoru Wakamori; Yasuo Mori; Takashi Iwashita

  FEBS Letters, 07 Aug. 2007, Peer-reviewed

  
• レスベラトロールがメタボリックシンドロームを改善する?

  菅瀬 謙治

  ファルマシア, Jul. 2007, Peer-reviewed, Invited, Lead author, Last author, Corresponding author

  
• Mechanism of coupled folding and binding of an intrinsically disordered protein

  Kenji Sugase; H. Jane Dyson; Peter E. Wright

  Nature, Jun. 2007, Peer-reviewed, Lead author

  
• Solution structure of IsTX, a male scorpion toxin from O-madagascariensis

  Nahoko Yamaji; Li Dai; Kenji Sugase; Marta Andriantsiferana; Terumi Nakajima; Takashi Iwashita

  Peptides 2004, Proceedings, 2005, Peer-reviewed

  
• Solution structure of IsTX. A male scorpion toxin from Opisthacanthus madagascariensis (Ischnuridae)

  Nahoko Yamaji; Li Dai; Kenji Sugase; Marta Andriantsiferana; Terumi Nakajima; Takashi Iwashita

  European Journal of Biochemistry, 10 Sep. 2004, Peer-reviewed

  
• Receptor-bound characteristics of MiniANP analyzed by NMR, MM/MD, and the use of unusual amino acids

  K. Sugase; M. Horikawa; M. Ishiguro

  Peptide Revolution: Genomics, Proteomics & Therapeutics, 2004, Peer-reviewed

  
• Restriction of a Peptide Turn Conformation and Conformational Analysis of Guanidino Group Using Arginine-Proline Fused Amino Acids:  Application to Mini Atrial Natriuretic Peptide on Binding to the Receptor

  Kenji Sugase; Manabu Horikawa; Masako Sugiyama; Masaji Ishiguro

  Journal of Medicinal Chemistry, 01 Jan. 2004, Peer-reviewed, Lead author

  
• Structure–activity relationships for mini atrial natriuretic peptide by proline-Scanning mutagenesis and shortening of peptide backbone

  Kenji Sugase; Yoshiaki Oyama; Katsuhiko Kitano; Hideo Akutsu; Masaji Ishiguro

  Bioorganic and Medicinal Chemistry Letters, May 2002, Peer-reviewed, Lead author

  
• Designing Analogues of Mini Atrial Natriuretic Peptide Based on Structural Analysis by NMR and Restrained Molecular Dynamics

  Kenji Sugase; Yoshiaki Oyama; Katsuhiko Kitano; Takashi Iwashita; Toshimichi Fujiwara; Hideo Akutsu; Masaji Ishiguro

  Journal of Medicinal Chemistry, 01 Feb. 2002, Peer-reviewed, Lead author

  
• Designing Analogs of Mini Atrial Natriuretic Peptide Based on Structural Analysis by NMR and Restrained Molecular Dynamics

  Sugase Kenji; Oyama Yoshiaki; Kitano Katsuhiko; Iwashita Takashi; Fujiwara Toshimichi; Akutsu Hideo; Ishiguro Masaji

  Symposium on Chemical Information and Computer Sciences
  Symposium on Structure-Activity Relationships, 2001, Lead author

  
• Characterization of a Receptor-Bound Conformation of Mini Atrial Natriuretic Peptide

  K. Sugase; Y. Oyama; K. Kitano; T. Iwashita; T. Fujiwara; H. Akutsu; M. Ishiguro

  Biochemical Society Transactions, 01 Oct. 2000, Lead author

  
• Synthesis of the cyclic heptapeptide Substance P antagonist, dihydro-WIN67689 and determination of the stereochemistry of the modified tyrosine moiety

  Yuan-Qiang Li; Kenji Sugase; Masaji Ishiguro

  Tetrahedron Letters, Dec. 1999, Peer-reviewed

  
• 13C-13C and 13C-15N Dipolar Correlation NMR of Uniformly Labeled Organic Solids for the Complete Assignment of Their 13C and 15N Signals: An Application to Adenosine

  Toshimichi Fujiwara; Kenji Sugase; Masatsune Kainosho; Akira Ono; Akira Ono; Hideo Akutsu

  Journal of the American Chemical Society, Nov. 1995, Peer-reviewed

  
• Iron Acquisition Mechanism of Graminaceous Plants by Mugineic Acids

  Murata Yoshiko; Namba Kosuke; Ma Jian Feng; Sugase Kenji; Horikawa Manabu; Iwashita Takashi; Kusumoto Shoichi

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Sep. 2009

  
• Structural Insights into Methylated DNA Recognition by the Methyl-CpG Binding Domain of MBD6 from Arabidopsis thaliana

  Yutaka Mahana; Izuru Ohki; Erik Walinda; Daichi Morimoto; Kenji Sugase; Masahiro Shirakawa

  ACS Omega, 19 Jan. 2022, Peer-reviewed

  Access this paper :

  

Misc.

• シロイヌナズナ由来のタンパク質MBD6によるメチル化DNA認識の構造基盤

  真鼻裕; 岩川直都; 尾野有菜; 大木出; ヴァリンダ エリック; 森本大智; 菅瀬謙治; 白川昌宏

  日本細胞生物学会大会(Web), 2019

  
• シロイヌナズナのDNA結合タンパク質MBD6の構造解析

  真鼻裕; 岩川直都; 尾野有菜; 大木出; WALINDA Erik; 森本大智; 菅瀬謙治; 白川昌宏

  日本分子生物学会年会プログラム・要旨集(Web), 2018

  
• ユビキチン化に伴うタンパク質構造不安定化

  森本大智; WALINDA Erik; 菅瀬謙治; 深田はるみ; 曽友深; 蔭山俊; 蔭山俊; 星野大; 藤井高志; 土屋光; 佐伯泰; 有田恭平; 有吉眞理子; 杤尾豪人; 岩井一宏; 難波啓一; 難波啓一; 小松雅明; 小松雅明; 田中啓二; 白川昌宏

  Abstracts. Annual Meeting of the NMR Society of Japan, 2014

  
• ヒト主要組織適合複合体の揺らぎが安定性に与える影響について

  谷中冴子; 菅瀬謙治; 上野貴将; 津本浩平

  日本蛋白質科学会年会プログラム・要旨集, 2012

  
• ヒト主要組織適合複合体の安定化機構に関する解析

  谷中冴子; 菅瀬謙治; 上野貴将; 津本浩平

  Abstracts. Annual Meeting of the NMR Society of Japan, 2012

  
• ヒト主要組織適合複合体(HLA)の揺らぎが傷害性T細胞(CTL)に与える影響について

  谷中冴子; 菅瀬謙治; 上野貴将; 津本浩平

  日本蛋白質科学会年会プログラム・要旨集, 2011

  
• ヒト主要組織適合複合体の動的構造と傷害性T細胞の活性の関連について

  谷中冴子; 上野貴将; 本園千尋; 菅瀬謙治; 津本浩平

  日本蛋白質科学会年会プログラム・要旨集, 2010

  
• ヒト主要組織適合複合体の動的なペプチド認識および構造維持機構

  谷中冴子; 菅瀬謙治; 上野貴将; 津本浩平

  日本蛋白質科学会年会プログラム・要旨集, 2013

  
• NMRを用いたヒト主要組織適合複合体の動的なペプチド認識及び構造維持機構の解明

  谷中冴子; 上野貴将; YI Shi; QI Jianxun; GAO George; 津本浩平; 菅瀬謙治

  Abstracts. Annual Meeting of the NMR Society of Japan, 2013

  
• Characterization of a Receptor-Bound Conformation of Mini Atrial Natriuretic Peptide

  SUGASE Kenji; OYAMA Yoshiaki; KITANO Katsuhiko; IWASHITA Takashi; FUJIWARA Toshimichi; AKUTSU Hideo; ISHIGURO Masaji

  Peptide science : proceedings of the ... Japanese Peptide Symposium, 01 Mar. 2001

  
• The deamination of APOBEC3G os controlled by the sliding-direction-dependent catalytic activity, and anti-prion activity of an RNA aptamer and its structural basis

  Furukawa, A; Sugase, K; Morishita, R; Nagata, T; Takaori-Kondo, A; Ryo, A; Mashima, T; Nishikawa, F; Nishikawa, S; Kamatari, Y; Kuwata, K; Katahira, M

  The 10th Korea-Japan Bilateral Symposium, 2013, Invited

  Access this misc :

  
• タンパク質の構造破綻とその関連疾患 物性化学から臨床まで 細胞内におけるユビキチン陽性タンパク質凝集体の形成機構の解明

  森本 大智; ヴァリンダ・エリック; 深田 はるみ; 菅瀬 謙治; 蔭山 俊; 星野 大; 難波 啓一; 小松 雅明; 田中 啓二; 白川 昌宏

  日本生化学会大会プログラム・講演要旨集, Sep. 2016

  
• 細胞周期中のCCANの構成の動的な変化(Dynamic Change of CCAN organization during the cell cycle)

  Nagpal Harsh; 堀 哲也; Furukawa Ayako; 菅瀬 謙治; 越阪部 晃永; 胡桃坂 仁志; 深川 竜郎

  日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015

  
• Deamination mechanism of an anti-HIV APOBEC3G coupled with sliding on single-stranded DNA as analyzed by real-time NMR monitoring method

  K. Kanba; A. Furukawa; K. Sugase; T. Nagata; M. Katahira

  The 41st International Symposium on Nucleic Acids Chemistry.Fukuoka, Nov. 2014

  
• Real-time NMR monitoring of enzymatic reaction of anti-HIV protein, structure of anti-prion RNA aptamer and wood biomass analysis

  Kanba, K; Mashima, T; Okamura, H; Furukawa, A; Sugase, K; Nishimura, H; Watanabe, T; Nagata, T; Katahira, M

  The 5th Japan-Taiwan NMR symposium, Sep. 2014

  
• Functional mechanism of an anti-HIV protein, APOBEC3G, as revealed by real-time NMR monitoring of its enzymatic reaction

  K. Kanba; A. Furukawa; K. Sugase; R. Morishita; T. Nagata; M. Katahira

  XXVIth International Conference on Magnetic Resonance in Biological Systems.Dallas, Aug. 2014

  
• The Dynamic Peptide Recognition And Stabilization Mechanism Of Human Leukocyte Antigen B*35:01

  Saeko Yanaka; Takamasa Ueno; Kouhei Tsumoto; Kenji Sugase

  PROTEIN SCIENCE, Jul. 2014

  
• Elucidation Of The Nonspecific DNA-Binding Mechanism Of The POU Homeodomain Using NMR

  Tsuyoshi Konuma; Erisa Harada; Takashi Oda; Mamoru Sato; Kenji Sugase

  PROTEIN SCIENCE, Jul. 2014

  
• Functional mechanism of anti-HIV protein, APOBEC3G, elucidated by real-time monitoring of enzymatic reaction, and anti-prion activity of an RNA aptamer with its structural basis

  K. Kanba; A. Furukawa; K. Sugase; R. Morishita; T. Nagata; M. Katahira

  The 45th Annual Meeting of Korean Magnetic Resonance Society, Jul. 2014, Invited

  
• ヘムオキシゲナーゼ分子表面に存在するF79の変異導入解析から見出された電子伝達機構

  原田 二朗; 原田 英里砂; 東元 祐一郎; 佐藤 秀明; 杉島 正一; 平 順一; 福山 恵一; 菅瀬 謙治; 野口 正人

  日本生化学会大会プログラム・講演要旨集, Dec. 2012

  
• 抗HIV宿主因子 APOBEC3Gの位置依存的デアミネーション反応機構の解明

  Furukawa, A; Sugase, K; Morishita, R; Nagata, T; Ryo, A; Takaori, A; Katahira, M

  日本生物物理学会第50回年会.名古屋, Sep. 2012

  
• Elucidation of the location-dependent deamination reaction mechanism of an anti-HIV factor,APOBEC3G

  A. Furukawa; K. Sugase; R. Morishita; A. Ryo; A. akaori; T. Nagata; M. Katahira

  XXV international Conference on Magnetic Resonance in Biological Systems，2012, Aug. 2012

  
• Anti-prion activity and it strucural basis of RNAaptamer, and sliding-direction-dependent deaminase activity of anti-HIV enzyme

  T. Mashima; A. Furukawa; K. Sugase; H. Fujiwara; F. Nishikawa; R. Morishita; A. Ryo; Y. Kamatari; T. Nagata; S. Nishikawa; K. Kuwata; M. Katahira

  XXV international Conference on Magnetic Resonance in Biological Systems，2012.Lyon,2012.8.19-24., Aug. 2012

  
• アミロイド線維形成時に現れる過渡的中間体のキャラクタリゼーション

  柳浩太郎; 櫻井一正; 吉村優一; 小沼剛; LEE Young‐Ho; 菅瀬謙治; 池上貴久; 内木宏延; 後藤祐児

  日本蛋白質科学会年会プログラム・要旨集, 31 May 2012

  
• Sliding-direction-dependent activity of anti-HIV enzyme,and structural basis of anti-prion activity of RNA aptamer

  Furukawa, A; Mashima, T; Sugase, K; Fujiwara, H; Nagata, T; Morishita, R; Ryo, A; Nishikawa, F; Nishikawa, S; Kamatari, KO; Kuwata, K; Katahira, M

  Korea-Japan Bilateral NMR Symposium, 16 Mar. 2012

  
• Design Strategy for High Free-Energy States of Proteins Based on High-Pressure NMR Study: Alternatively Folded Conformation of Ubiquitin

  Ryo Kitahara; Soichiro Kitazawa; Maho Yagi-Utsumi; Akemi Ido; Makoto Urushitani; Kenji Sugase; Koichi Kato

  BIOPHYSICAL JOURNAL, Jan. 2012

  
• Real-time monitoring of the cytidine deamination along single-stranded DNA by an anti-HIV factor, APOBEC3G

  Furukawa, A; Sugase, K; Morishita, R; Nagata, T; Ryo, A; Takaori, A; Katahira, M

  The International Symposium on Nuclear Magnetic Resonance 2011, Nov. 2011

  
• Base-deamination rate dependent on the direction of sliding of an enzyme along DNA as revealed by numerical analysis of NMR data, and wood biomass studied by solution NMR

  NISHIMURA Hiroshi; FURUKAWA Ayako; OKAMURA Hideyasu; KOZAWA Yu; MORISHITA Ryo; RYO Akihide; SUGASE Kenji; WATANABE Takashi; KATAHIRA Masato

  Abstr Annu Meet NMR Soc Jpn, 21 Oct. 2011, Peer-reviewed

  
• ヘムオキシゲナーゼの変異体の解析から考察される電子伝達経路

  原田 二朗; 原田 英里砂; 東元 祐一郎; 佐藤 秀明; 杉島 正一; 平 順一; 福山 恵一; 菅瀬 謙治; 野口 正人

  日本生化学会大会プログラム・講演要旨集, Sep. 2011

  
• 溶液NMRによるβ2ミクログロブリンアミロイド線維形成のモノマー‐線維核相互作用機構の解明

  櫻井一正; 柳浩太郎; 吉村優一; 小沼剛; 菅瀬謙治; 池上貴久; 内木宏延; 後藤祐児

  日本蛋白質科学会年会プログラム・要旨集, 27 May 2011

  
• SOLUTION STRUCTURE OF ISTX, A MALE SCORPION TOXIN FROM O. MADAGASCARIENSIS

  N. Yamaji; L. Dai; K. Sugase; M. Andriantsiferana; T. Nakajima; T. Iwashita

  JOURNAL OF PEPTIDE SCIENCE, 2004

  
• Receptor-bound characteristics of minianp analyzed by NMR, MM/MD, and the use of unusual amino acids

  K Sugase; M Horikawa; M Ishiguro

  BIOPOLYMERS, 2003

  
• Multidimensional Solid-State NMR for the Structural Analysis of Isotope-Labeled Biomolecules

  SASA K.; SUGASE K.; MORIKAWA S.; FUJIWARA T.; AKUTU H.

  Biophysics, Oct. 1997

  

Presentations

• Rheo-NMRによる アミロイド線維化過程のリアルタイム計測

  菅瀬謙治

  第42回 日本認知症学会学術集会, 25 Nov. 2023, Invited

  
• 動的溶液環境下の タンパク質の動的構造

  菅瀬謙治

  基雕加5学最新NMR解析法 第7回ワークショップ タンパク質のダイナミクスと機能, 03 Oct. 2023, Invited

  
• NMRによる動的溶液環境に応答する天然変性タンパク質の動的構造解析

  菅瀬謙治

  2022年度 中性子構造生物学研究会「天然変性タンパク質」, 22 Mar. 2023, Invited

  
• High-sensitivity Rheo-NMR

  Kenji Sugase

  The 7th International Symposium on Drug Discovery and Design by NMR, 27 Oct. 2022, Invited

  
• Mechanism of amyloid fibrillation of a protein driven by flow-induced physical perturbation

  Kenji Sugase

  Joint Meeting of the 20th KIAS Conference on "Protein Structure and Function", 14 Sep. 2022, Invited

  
• 基礎講座

  菅瀬謙治

  第21回若手NMR研究会, Sep. 2021, Invited

  
• Rheo-NMRによるタンパク質のアミロイド線維化過程のリアルタイム計測

  菅瀬謙治

  第21回日本蛋白質科学会年会, Jun. 2021, Invited

  
• 高感度Rheo-NMRによる剪断流中のタンパク質の動的構造解析

  菅瀬謙治

  20-1 NMR研究会, 20 Dec. 2020, Invited

  
• In situ Monitoring of Amyloid Fibril Formation Processes Using Rheo-NMR

  Sugase K; Morimoto D; Walinda E; Iwakawa N; Yamamoto A; Scheler U

  8th Asia-Pacific NMR Symposium 2019, 04 Jul. 2019, Invited

  
• In situ monitoring of amyloid fibril formation processes using Rheo-NMR

  Kenji Sugase

  RIKEN Symposium Recent Progress in Protein Conformation and Aggregation, 24 Jan. 2019, Invited

  
• In situ Monitoring of Protein Fibrillation Using High-Sensitivity Rheo-NMR

  SUGASE Kenji

  日本表面真空学会 2018年9月研究例会, 28 Sep. 2018, Invited

  
• High-Sensitivity Rheo-NMR Spectroscopy for Protein Studies

  Kenji Sugase

  JGP-Chem Kyoto-Bordeaux Faculty & Student Research Workshop on Chiral Nanostructures for Photonic Applications, 26 Oct. 2017, Invited

  
• 天然変性タンパク質の 動的構造研究の進展

  菅瀬 謙治

  第89回 日本生化学会大会, 27 Sep. 2016, Invited

  
• Elucidation of potential sites for antibody engineering by fluctuation editing

  Kenji Sugase

  The 5th International Symposium on Drug Discovery and Design by NMR, 30 Aug. 2016, Invited

  
• 天然変性タンパク質の 多様な標的分子結合機構

  菅瀬 謙治

  第16回 日本蛋白質科学会年会, 09 Jun. 2016, Invited

  
• NMRによる生体高分子の動的構造解析

  菅瀬 謙治

  新学術領域「柔らかな分子系」ワークショップ 『ダイナミクス観測からタンパク質の「柔らかさ」を観る』, 01 Mar. 2016, Invited

  
• NMRによる天然変性タンパク質の 動的構造の先端研究

  菅瀬 謙治

  日本分光学会NMR分光部会 集中講義, 30 Sep. 2015, Invited

  
• Heme oxygenase-2 activity regulated by the C-terminal intrinsically disordered region

  Kenji Sugase

  The 11th Japan-Korea Bilateral Symposium on Biological NMR & International NMR Symposium on Pharmaceutical NMR, 19 Dec. 2014, Invited

  
• ヒト主要組織適合複合体の 動的なペプチド認識と構造維持機構

  菅瀬 謙治

  日本生物物理学会 東北支部会2014, 05 Sep. 2014, Invited

  
• Structural dynamics of Sox2 upon binding to DNA

  Kenji Sugase

  ICMRBS XXVI, 25 Aug. 2014, Invited

  
• Dynamics of nuclear proteins analyzed by relaxation NMR spectroscopy

  Kenji Sugase

  The 4th Asia Pacific Protein Association Conference, 18 May 2014, Invited

  
• HLA-HIV由来抗原ペプチド複合体-水 のダイナミクスと抗原提示能

  菅瀬謙治

  関西創薬化学コミュニティ, 07 Mar. 2014, Invited

  
• Mechanism of the distal regulation of substrate binding through intrinsic fluctuation in an enzyme

  Kenji Sugase

  The 10th Korea-Japan Bilateral Symposium on Biological NMR, 04 Jul. 2013, Invited

  
• 揺らぎが制御するヘム分解酵素反応の遠位効果

  菅瀬謙治

  第14回若手NMR研究会, 30 Jun. 2013, Invited

  
• Regulation of substrate-binding by a hidden distal effect via intrinsic fluctuation

  Kenji Sugase

  Academia Sinica Seminor, 30 Jan. 2013, Invited

  
• R2 dispersion spectroscopy

  Kenji Sugase

  2013 Taiwan magnetic resonance society annual meeting, 29 Jan. 2013, Invited

  
• Mechanism of coupled folding and binding of an intrinsically disordered protein

  Kenji Sugase

  2013 Taiwan magnetic resonance society annual meeting, 29 Jan. 2013, Invited

  
• Regulation of substrate-binding by a hidden distal effect via intrinsic fluctuation

  Kenji Sugase

  4-th France-Japan Joint Seminar, 07 Jan. 2013, Invited

  
• Relaxation NMR for protein dynamics and interaction studies

  菅瀬謙治

  Pharmaceutical NMR lecture series in Osaka, 25 Oct. 2012, Invited

  
• 動的構造解析による酵素ヘムオキシゲナーゼのヘム認識機構の解明

  菅瀬謙治

  第45回構造生物応用研究会, 16 Jun. 2012, Invited

  
• 揺らぎから機能をどのように見るか

  菅瀬謙治

  よこはまNMR構造生物学研究会 第43回ワークショップ：計算科学とNMRの融合に向けて, 06 Feb. 2012, Invited

  
• 天然変性タンパク質の共役した折り畳みと結合のメカニズム

  菅瀬謙治

  神戸大学先端融合科学シンポジウム, 30 Jan. 2012, Invited

  
• 蛋白質の構造変化を捉えるNMR分光法

  菅瀬謙治

  京都大学分子工学コロキウム, 20 Dec. 2011, Invited

  
• 動的構造解析による酵素ヘムオキシゲナーゼの機能発現メカニズムの解明

  菅瀬謙治

  第17回創薬情報研究会, 13 Sep. 2011, Invited

  
• ヘム分解酵素の動的構造解析-蛋白質工学への応用をめざして

  菅瀬謙治

  よこはまNMR構造生物学研究会 第41回ワークショップ 「最先端NMR技術で切り拓く構造生物学の未来」, 02 Mar. 2011, Invited

  
• 核内蛋白質の構造変化と機能

  菅瀬謙治

  首都大学東京コロキウム, 26 Jan. 2011, Invited

  
• NMRによる蛋白質の動的構造解析 －核内蛋白質と酵素の標的分子認識機構－

  菅瀬謙治

  大阪大学バイオ関連多目的研究施設セミナー, 11 Nov. 2010, Invited

  
• Fluctuation and function of nuclear proteins

  菅瀬謙治; 原田英里砂

  第48回日本生物物理学会年会, 20 Sep. 2010, Invited

  
• ＮＭＲによるヘムオキシゲナーゼのヘム認識機構の解明

  原田英里砂; 杉島正一; 野口正人; 福山恵一; 菅瀬謙治

  大阪大学蛋白質研究所セミナー, 30 Jul. 2010, Invited

  
• NMRによる天然変性タンパク質の動的構造解析

  菅瀬謙治

  第10回日本蛋白質科学会年会, 18 Jun. 2010, Invited

  
• 動きの面から見た核内タンパク質の機能

  菅瀬謙治

  ターゲットタンパク研究プログラム第3回研究交流会, 04 Mar. 2010, Invited

  
• 天然変性状態と機能の相関

  菅瀬謙治

  第32回日本分子生物学会年会, 11 Dec. 2009, Invited

  
• Elucidating protein-protein interactions using relaxation dispersion spectroscopy

  菅瀬謙治

  大阪大学 産業科学研究所セミナー, 16 Oct. 2009, Invited

  
• 天然変性タンパク質の構造と機能の最前線

  菅瀬謙治

  第49回生命科学 夏の学校, 30 Aug. 2009, Invited

  
• 天然変性タンパク質の構造変化と機能

  菅瀬謙治

  北海道大学セミナー, 01 Jun. 2009, Invited

  
• Elucidating protein-protein interactions using relaxation spectroscopy on high-field NMR

  Kenji Sugase

  IMS Nanoforum “New Vistas of Molecular Sciences by Ultra-high Field NMR Spectroscopy”, 22 Jan. 2009, Invited

  
• Relaxation Dispersion法を用いた機能相関

  菅瀬謙治

  BMB2008, 11 Dec. 2008, Invited

  
• NMRで分かる分子間相互作用のダイナミクス

  菅瀬謙治

  立命館大学理工学研究所シンポジウム タンパク質NMR研究の最前線, 29 Nov. 2008, Invited

  
• 緩和速度解析による“見えない相互作用”の検出

  菅瀬謙治

  理研NMR講演会, 06 Oct. 2008, Invited

  
• NMRで分かるタンパク質のダイナミクス

  菅瀬謙治

  第9回若手NMR研究会, 15 Sep. 2008, Invited

  
• NMRで分かる分子間相互作用のダイナミクス

  菅瀬謙治

  横浜市立大学セミナー, 05 Sep. 2008, Invited

  
• 天然変性蛋白質と遭遇複合体

  菅瀬謙治; H. Jane Dyson; Peter E. Wright

  第8回日本蛋白質科学会年会, 10 Jun. 2008, Invited

  
• NMRによる構造変化の研究

  菅瀬謙治

  大阪大学蛋白質研究所セミナー, 03 Mar. 2008, Invited

  
• Relaxation dispersion NMRによる準安定構造の検出

  菅瀬謙治; H. Jane Dyson; Peter E. Wright

  日本生物物理学会第45回年会, 21 Dec. 2007, Invited

  
• 天然変性蛋白の連結した結合と折り畳みのメカニズム

  菅瀬謙治

  GCOE・P&P先端技術講習会, 07 Nov. 2007, Invited

  
• Protein-protein interaction characterized by NMR relaxation dispersion spectroscopy

  Kenji Sugase

  International Symposium on Drug Discovery and Design by NMR, 22 Oct. 2007, Invited

  
• NMR Relaxation dispersion法により描写される蛋白質－蛋白質相互作用の中間体

  菅瀬謙治

  日本薬学会東海支部 特別講演会, 19 Sep. 2007, Invited

  
• 結合と連動した蛋白質フォールディングの熱力学と動力学

  菅瀬謙治; H. Jane Dyson; Peter E. Wright

  大阪大学蛋白質研究所セミナー, 29 Sep. 2006, Invited

  

Books and Other Publications

• タンパク質の構造解析手法と In silicoスクリーニングへの応用事例 ～AlphaFold、In silico創薬、NMR、X線、クライオ電子顕微鏡～

  森本大智; 菅瀬謙治, Contributor, 第3節 タンパク質を多角的に捉えるNMR測定法

  技術情報協会, Jul. 2023

  
• NMRによる有機材料分析とその試料前処理、データ解釈

  森本大智; 菅瀬謙治, Joint work, 第2節 Rheo-NMRによる生体高分子の動的構造解析

  技術情報協会, Sep. 2021

  Find Kyoto University's collection of books :

  
• Experimental Approaches of NMR Spectroscopy

  Walinda E; Sugase K, Joint work, chapter 7: Elucidating functional dynamics by R1ρ and R2 relaxation dispersion NMR spectroscopy.

  Springer, 2018, Not refereed

  Find Kyoto University's collection of books :

  
• 揺らぎ・ダイナミクスと生体機能 物理化学的視点から見た生体分子

  菅瀬 謙治, Joint work, 5章 NMR

  化学同人, Sep. 2013, Not refereed

  
• Handbook of Oxytocin Research: Synthesis, Storage and Release, Actions and Drug Forms

  Kawada T; Sekiguchi T; Sugase K; Kanda A; Satake H, Joint work, 59-85

  Nova Science Publishers, 2009, Not refereed

  
• Water and Biomolecules: Physical Chemistry of Life Phenomena (Biological and Medical Physics, Biomedical Engineering)

  Wright PE; Felitsky DJ; Sugase K; Dyson HJ, Joint work, 1-11

  Springer-Verlag, 2009, Not refereed

  

Industrial Property Rights

• 特願2023-170462, 剪断流を発生させる器具

  菅瀬謙治; 森本大智; 山本昭彦; 保科好秀

  
• 特許第7255801号, 特開2020-204481, 特願2019-111013, 剪断流を発生させる器具

  菅瀬謙治; 森本大智; 保科好秀

  

Media Coverage

• ATPがタンパク質凝集を抑制

  科学新聞, 3面, 20 Aug. 2021, Paper

  
• たんぱく質アミロイド線維化 ATP、結合抑える

  日刊工業新聞, 17面, 13 Aug. 2021, Paper

  
• 高分解能で過程観察 アミロイド線維化発症の仕組み解明へ

  日刊工業新聞2, 20 Jul. 2021, Paper

  

External funds: Kakenhi

• NMR study on local structural fluctuations of double-stranded DNA

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (III)

  Kyoto University

  菅瀬 謙治

  From 10 Sep. 2021, To 31 Mar. 2023, Granted

  NMR;二本鎖DNA;動的構造;エピゲノム修飾;溶液環境

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-21H05746/
• Elucidation of the mechanism of amyloid fibrillation of alpha-synuclein starting from liquid-liquid phase separation

  Grant-in-Aid for Scientific Research (B)

  Basic Section 43040:Biophysics-related

  Kyoto University

  菅瀬 謙治

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  液-液相分離;アミロイド線維;αシヌクレイン;剪断流;Rheo-NMR;アミロイド線維化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02442/
• Development of a new methodology for determining dissociation constants of proteins and drugs in cells

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields

  Kyoto University

  Kenji Sugase

  From 30 Jul. 2020, To 31 Mar. 2022, Project Closed

  タンパク質－薬剤相互作用;難水溶性薬剤;解離定数;in-cell NMR;19F-NMR;化学交換;タンパク質‐薬剤相互作用;細胞内環境;NMR

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K21391/
• Velocity imaging of turbulence flow using Rheo-NMR

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

  Medium-sized Section 13:Condensed matter physics and related fields

  Kyoto University

  Kenji Sugase

  From 09 Oct. 2018, To 31 Mar. 2022, Project Closed

  Rheo-NMR;速度イメージング;off-center Couette cell;乱流;タンパク質凝集;線維化

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18KK0075/
• Analysis of the effects of crowded environment and shear force to proteins using Rheo-NMR

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Kyoto University

  菅瀬 謙治

  From 01 Apr. 2018, To 31 Mar. 2020, Project Closed

  細胞内夾雑環境;タンパク質;安定化/不安定化;アミロイド線維化;ATP;NMR;Rheo-NMR;夾雑環境;剪断力;安定性;細胞抽出液

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-18H04551/
• Elucidation of the mechanism of amyloid fibrillation using Rheo-NMR and development of a new Rheo-NMR instrument

  Grant-in-Aid for Challenging Research (Exploratory)

  Kyoto University

  Kenji Sugase

  From 30 Jun. 2017, To 31 Mar. 2020, Project Closed

  Rheo-NMR;タンパク質;アミロイド線維;NMR;レオロジー;蛋白質;生物物理;流体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19196/
• Activation mechanism of ubiquitin ligase parkin by PINK1 and phosphorylated ubiquitin

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Kenji Sugase

  From 01 Apr. 2015, To 31 Mar. 2019, Project Closed

  parkin;リフォールディング;大量発現系;NMR;タンパク質;分子認識;Parkin;ユビキチン;動的構造;PINK1;リン酸化ユビキチン;蛋白質;生物物理;高分子構造・物性

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04342/
• Ultra-fast NMR measurement to analyze dynamics of Sox2 in cells

  Grant-in-Aid for Challenging Exploratory Research

  Suntory Foundation for Life Sciences

  Kenji SUGASE

  From 01 Apr. 2013, To 31 Mar. 2015, Project Closed

  in-cell NMR;タンパク質;揺らぎ;高速測定;高速NMR法

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25650056/
• Elucidating a DNA recognition mechanism of a transcriptional factor protein by characterizing dynamic processes of specific/non-specific DNA-bound complexes

  Grant-in-Aid for Young Scientists (B)

  Suntory Foundation for Life Sciences

  ERISA HARADA

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  NMR;蛋白質構造

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24770106/
• Elucidation of dynamics and function of an iPS cell reprogramming factor Sox2 from the view point of an intrinsically disordered protein

  Grant-in-Aid for Young Scientists (B)

  Suntory Institute for Bioorganic Research

  Kenji SUGASE

  From 01 Apr. 2009, To 31 Mar. 2011, Project Closed

  分子認識及び相互作用;分子認識および相互作用

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21770126/
• Mechanism analysis of sulfobetaines' activity to prevent protein aggregation and application of sulfobetaines to unstable proteins

  Grant-in-Aid for Scientific Research (C)

  Gunma University

  Kaori WAKAMATSU

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  タンパク質;凝集防止;安定化;スルホベタイン;メカニズム;運動性;オスモライト;分子サイズ;溶解度;凝集;変性;抗体;精製;収率;効率化;構造多型;NMR;NDSB;立体構造解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21570108/
• Iron acquisition mechanism of graminaceous plants by mugineic acids

  Grant-in-Aid for Scientific Research (B)

  Suntory Institute for Bioorganic Research

  Yoshiko MURATA

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  ムギネ酸;鉄錯体;イネ科植物;トランスポーター;ファイトシデロフォア;ムギネ酸鉄錯体トランスポーター;基質選択性;イネ科食物;オオムギ;光親和標識体;鉄輸送;標識体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21310148/
• Characterization of structural dynamics of intrinsically disordered proteins

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Yokohama City University

  Satoko AKASHI

  From 23 Jul. 2009, To 31 Mar. 2014, Project Closed

  蛋白質;生体分子;NMR;質量分析;天然変性;ＮＭＲ;蛋白;生子

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-21113003/
• NMR緩和分散法によるiPS細胞誘導因子Oct3/4の揺らぎの検出

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Science and Engineering

  Suntory Institute for Bioorganic Research

  菅瀬 謙治

  From 01 Apr. 2009, To 31 Mar. 2011, Project Closed

  揺らぎの検出;蛋白質;NMR

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-21107531/
• 膜との相互作用によるグレリンの生理活性の調節機構

  Grant-in-Aid for Young Scientists (B)

  Suntory Institute for Bioorganic Research

  菅瀬 謙治

  From 01 Apr. 2003, To 31 Mar. 2005, Project Closed

  グレリン;リン脂質膜;マイクロカロリメトリー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15710169/
• Elucidation of the mechanism of protein aggregation in flow by using Rheo-NMR and Rheo-MD

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Complex systems

  Kyoto University

  菅瀬 謙治

  From 01 Apr. 2022, To 31 Mar. 2024, Granted

  剪断流;会合;Rheo-NMR;Rheo-MD;αシヌクレイン

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-22H04842/
• Atomic-level analysis of proteins responding to dynamic solution environments using NMR

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (III)

  Kyoto University

  菅瀬 謙治

  From 20 May 2022, To 31 Mar. 2025, Granted

  ATP;非膜オルガネラ;アミロイド線維;Rheo-NMR;電場NMR;in-cell NMR;膜なしオルガネラ

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22H05088/
• 動的溶液科学の推進

  Grant-in-Aid for Transformative Research Areas (B)

  Transformative Research Areas, Section (III)

  Kyoto University

  関山 直孝

  From 20 May 2022, To 31 Mar. 2025, Granted

  液液相分離;非膜型オルガネラ;天然変性タンパク質;アミロイド線維;動的溶液環境;液-液相分離;アミロイド線維化

  https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-22H05087/
• Development of analytical platform for proteins in electric field and its application

  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))

  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields

  Kyoto University

  菅瀬 謙治

  From 07 Oct. 2022, To 31 Mar. 2026, Granted

  電場;NMR;タンパク質;電気泳動;凝集

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22KK0098/
• Investigation of molecular aggregation control mechanism by solution environment and creation of molecular design tools

  Grant-in-Aid for Scientific Research (B)

  Basic Section 32010:Fundamental physical chemistry-related

  Nagoya University

  吉田 紀生

  From 01 Apr. 2024, To 31 Mar. 2028, Granted

  3D-RISM;酸化還元;超分子ゲル;分子シミュレーション;モンテカルロ法

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K01434/

External funds: others

• 電場中の生体分子の挙動を原子レベルで解析できる高感度・高分解能 電場NMR装置の開発 (2023年度分)

  公益財団法人JKA, 自転車等機械振興事業

  From 01 Apr. 2023, To 31 Mar. 2024

  研究代表者
• Development of molecular tools to analyze and control the liquid-liquid phase separation of proteins conjugated with redox states

  豊田理研, 豊田理研スカラー共同研究

  From 01 Apr. 2022, To 31 Mar. 2023

  菅瀬謙治
• 操作性良く高感度測定ができる新型Rheo-NMR装置の開発　 (2022年度分)

  公益財団法人JKA, 自転車等機械振興事業

  From 01 Apr. 2022, To 31 Mar. 2023

  研究代表者
• 緑茶カテキンによるアミロイド線維化抑制機構の解明

  一般財団法人東洋水産財団, 学術研究助成

  From 01 Jun. 2022, To 31 Mar. 2023

  菅瀬 謙治

  代表
• 新型コロナウイルス感染の重篤化に繋がるvWFが流れにより構造変化する機構の解明

  公益財団法人小柳財団, 研究助成

  From 01 Apr. 2022, To 31 Mar. 2023

  菅瀬 謙治

  代表
• 新型コロナ感染の重症化を引き起こす vWF の構造変化機構の解明

  東京化成化学振興財団, 研究助成

  From 01 Apr. 2022, To 31 Mar. 2023

  菅瀬 謙治

  代表
• 生命科学におけるATP-Mg会合体の構造と機能の解明

  京都大学教育研究振興財団, 研究活動推進支援

  From 01 May 2020, To 31 Mar. 2021

  菅瀬 謙治

  代表
• 光照射化における励起状態解析に基づく機能性分子の物性評価

  公益財団法人豊田理化学研究所, 豊田理研スカラー共同研究(Phase 2)

  From 01 Apr. 2020, To 31 Mar. 2021

  菅瀬 謙治

  代表
• 光照射化における励起状態解析に基づく機能性分子の物性評価

  公益財団法人豊田理化学研究所, 豊田理研スカラー共同研究(Phase 1)

  From 01 Nov. 2019, To 31 Mar. 2020

  菅瀬 謙治

  代表
• 剪断力により誘起される相分離の機構解明

  公益財団法人豊田理化学研究所, 豊田理研スカラー共同研究(Phase 2)

  From 01 Apr. 2019, To 31 Mar. 2020

  菅瀬 謙治

  代表
• 剪断力により誘起される相分離の機構解明

  公益財団法人豊田理化学研究所, 豊田理研スカラー共同研究 (Phase 1)

  From 01 Nov. 2018, To 31 Mar. 2019

  菅瀬 謙治

  代表
• 世界最高感度Rheo-NMR装置の開発

  公益財団法人豊田理化学研究所, 豊田理研スカラー

  From 01 Apr. 2018, To 31 Mar. 2018

  菅瀬 謙治

  代表
• 緑茶カテキンによるパーキンソン病予防効果の科学的立証

  一般財団法人生産開発科学研究所, 生研学術奨励資金

  From 01 Feb. 2018, To 31 Jan. 2019

  菅瀬 謙治
• in-cell NMRによる細胞中のライソゾーム病関連酵素の構造解析

  日本応用酵素協会, 酵素研究助成

  From 01 Apr. 2017, To 31 Mar. 2018

  菅瀬 謙治

  代表
• Rheo-NMR法によるアミロイド線維形成メカニズムの解明

  自然科学研究機構, 融合発展促進研究プロジェクト

  From 01 Oct. 2016, To 31 Mar. 2018

  菅瀬 謙治

  代表
• 操作性良く高感度測定ができる新型Rheo-NMR装置の開発 補助事業 (2021年度分)

  公益財団法人JKA, 自転車等機械振興事業

  From 01 Apr. 2021, To 31 Mar. 2022

  代表
• Mechanism of the coupled folding and binding of an intrinsically disordered protein

  The Skaggs Scholarship

  From 01 Sep. 2005, To 31 Aug. 2006

  Kenji Sugase

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Applied Life Sciences III

  CA03, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Biomacromolecular Chemistry

  CA21, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Applied Biochemistry

  CA29, Fall, Graduate School of Agriculture, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Macromolecular Bioscience Seminar

  CF02, Spring, Graduate School of Agriculture, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Macromolecular Bioscience Seminar

  CF02, Fall, Graduate School of Agriculture, 1.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course of Macromolecular Bioscience

  CG02, Spring, Graduate School of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course of Macromolecular Bioscience

  CG02, Fall, Graduate School of Agriculture, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  General Biomacromolecular Chemistry

  5633, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Analytical Chemistry

  5622, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Applied Life Science I

  5601, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Outline of Applied Life Sciences

  5801, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Structure and Function of Biomacromolecules

  5635, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Biomacromolecular Chemistry

  CA21, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Applied Life Sciences III

  CA03, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Applied Biochemistry

  CA29, Fall, Graduate School of Agriculture, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Macromolecular Bioscience Seminar2

  CB20, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Macromolecular Bioscience Seminar1

  CB19, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Course in Biochemistry

  5669, Year-long, Faculty of Agriculture, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course of Macromolecular Bioscience2

  CC20, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course of Macromolecular Bioscience1

  CC19, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2023, To 31 Mar. 2024

  Structure and Function of Biomacromolecules

  5635, Fall, Faculty of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  General Biomacromolecular Chemistry

  5633, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Analytical Chemistry

  5622, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Applied Life Science I

  5601, Spring, Faculty of Agriculture, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Applied Biochemistry

  CA29, Fall, Graduate School of Agriculture, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Physical Chemistry: Fundamentals and Exercises

  7102, Spring, Faculty of Engineering, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course of Macromolecular Bioscience1

  CC19, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Macromolecular Bioscience Seminar1

  CB19, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Biomacromolecular Chemistry

  CA21, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Applied Life Sciences III

  CA03, Spring, Graduate School of Agriculture, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Macromolecular Bioscience Seminar2

  CB20, Year-long, Graduate School of Agriculture, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course of Macromolecular Bioscience2

  CC20, Year-long, Graduate School of Agriculture, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Introduction to Applied Life Science I

  5601, Spring, Faculty of Agriculture, 2
• From Apr. 2015, To Mar. 2016

  Physical Chemistry III (Fundamental Chemistry)

  Fall, 工学部
• From Apr. 2015, To Mar. 2016

  Physical Chemistry: Fundamentals and Exercises

  Spring, 工学部
• From Apr. 2016, To Mar. 2017

  Physical Chemistry III (Fundamental Chemistry)

  Fall, 工学部
• From Apr. 2016, To Mar. 2017

  Physical Chemistry: Fundamentals and Exercises

  Spring, 工学部
• From Apr. 2016, To Mar. 2017

  Biomolecular Function Chemistry

  Spring, 工学研究科
• From Apr. 2017, To Mar. 2018

  Safty in Chemistry Laboratory

  Spring, 工学部
• From Apr. 2017, To Mar. 2018

  Physical Chemistry III (Fundamental Chemistry)

  Fall, 工学部
• From Apr. 2017, To Mar. 2018

  Physical Chemistry: Fundamentals and Exercises

  Spring, 工学部
• From Apr. 2018, To Mar. 2019

  Safty in Chemistry Laboratory

  Spring, 工学部
• From Apr. 2018, To Mar. 2019

  Physical Chemistry III (Fundamental Chemistry)

  Fall, 工学部
• From Apr. 2018, To Mar. 2019

  Physical Chemistry: Fundamentals and Exercises

  Spring, 工学部
• From Apr. 2018, To Mar. 2019

  Biomolecular Function Chemistry

  Spring, 工学研究科
• From Apr. 2019, To Mar. 2020

  Safty in Chemistry Laboratory

  Spring, 工学部
• From Apr. 2019, To Mar. 2020

  Physical Chemistry III (Fundamental Chemistry)

  Fall, 工学部
• From Apr. 2019, To Mar. 2020

  Physical Chemistry: Fundamentals and Exercises

  Spring, 工学部
• From Apr. 2020, To Mar. 2021

  Safty in Chemistry Laboratory

  Spring, 工学部
• From Apr. 2020, To Mar. 2021

  Physical Chemistry: Fundamentals and Exercises

  Spring, 工学部
• From Apr. 2020, To Mar. 2021

  Physical Chemistry III (Fundamental Chemistry)

  Fall, 工学部
• From Apr. 2020, To Mar. 2021

  Biomolecular Function Chemistry

  Spring, 工学研究科
• From Apr. 2021, To Mar. 2022

  Molecular Spectroscopy

  Fall, 工学研究科
• From Apr. 2021, To Mar. 2022

  Safty in Chemistry Laboratory

  Spring, 工学部
• From Apr. 2021, To Mar. 2022

  Physical Chemistry III (Advanced Chemistry)

  Fall, 工学部
• From Apr. 2021, To Mar. 2022

  Physical Chemistry: Fundamentals and Exercises

  Spring, 工学部

Participation in PhD Defense

• Physiological and biochemical studies on microbial 2´-deoxyribonucleotide　biosynthesis and oxidative pyrimidine metabolism

  DEGUCHI KENGO, Graduate School of Agriculture, Sub-chief Examiner

  25 Mar. 2024
• Insights into the structure and functionality of feruloyl esterases for the efficient utilization of lignocellulosic biomass

  APISAN PHIENLUPHON, Graduate School of Energy Science, Sub-chief Examiner

  25 Mar. 2024
• Development of functional cellomics for comprehensive analysis of the relationship between neural networks and behavior in Caenorhabditis elegans

  YAMAUCHI YUJI, Graduate School of Agriculture, Chief Examiner

  23 Mar. 2023
• Development of Direct Electron Transfer-Type Cascade System by Alcohol and Aldehyde Dehydrogenases

  ADACHI TAIKI, Graduate School of Agriculture, Sub-chief Examiner

  23 Mar. 2023

Student achievements: Awards

• APNMR Poster Award

  Kota Yoshioka, ISMAR-APNMR2021, 27 Aug. 2021
• APNMR Poster Award

  Takuya Hirakawa, ISMAR-APNMR, 27 Aug. 2021

Administration

Faculty management (title, position)

• From 01 Apr. 2023, To 31 Mar. 2025

  将来構想検討委員会　委員
• From 01 Apr. 2015, To 31 Mar. 2019

  工学研究科・工学部図書委員会　委員

Academic, Social Contribution

Committee Memberships

• From May 2023, To Present

  関西支部参与会, 日本農芸化学会
• From Mar. 2023, To Present

  会誌編集委員, 日本生物物理学会

Academic Contribution

• 動的溶液環境によるタンパク質の自己凝縮メカニズムの探求：新たな視点と未来への展望

  Planning, management, etc., Panel moderator

  第24回日本蛋白質科学会年会, From 12 Jun. 2024

  
• 動的溶液環境が駆動する生体内液液相分離とアミロイド線維化

  Planning, management, etc., Panel moderator

  第61回日本生物物理学会年会, From 15 Nov. 2023

  
• Integrated understanding of protein self-condensation process from the viewpoint of dynamic solution environments

  Planning, management, etc., Panel moderator

  第23回日本蛋白質化学会, From 07 Jul. 2023

  
• Protein aggregation driven by dynamic solution environments

  Planning, management, etc., Panel moderator

  第60回日本生物物理学会, From 28 Sep. 2022

  
• 動的溶液環境が駆動する天然変性タンパク質の自己凝縮過程

  Planning, management, etc., Panel moderator

  第22回日本蛋白質科学会, From 09 Jun. 2022