Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医学専攻／Department of Medicine 幹細胞医学／Stem Cell Medicine, 教授／Professor
• Graduate School of Medicine, 医科学専攻／Department of Medical Sciences 幹細胞医学／Stem Cell Medicine, 教授／Professor

Academic Degree

• M.D., Ph.D.(Kyoto University)

Academic Resume (Undergraduate School/Majors)

• 京都大学, 医学部医学科, 卒業

Research History

• From 2022, To Present

  Center for iPS Cell Research and Application, Head of Department of Fundamental Cell Technology
• From 2019, To Present

  Institute for Advancement of Clinical and Translational Science (iACT), Kyoto University Hospital,, Project Leader
• From 2017, To Present

  RIKEN BioResource Research Center (BRC), Team Leader, RIKEN Center for Advanced Intelligence Project (AIP), Senior Visiting Scientist
• From 2014, To Present

  Center for iPS Cell Research and Application (CiRA), Kyoto University,, Professor
• From 2009, To 2015

  Japan Science and Technology Agency CREST, Principal Investigator
• From 2010, To 2014

  CiRA, Kyoto University, Kyoto, Japan, Associate Professor
• From 2009, To 2010

  CiRA, iCeMS, Kyoto University, Kyoto, Japan, Associate Professor
• From 2005, To 2009

  Department of Neurology, Graduate School of Medicine, Kyoto University, Kyoto, Japan, Assistant Professor
• From 2004, To 2005

  Neuroregeneraion Laboratory, McLean Hospital/Harvard Medical School, Boston, MA, USA, Postdoctoral Fellow
• From 1999, To 2004

  Brain Science Institute, RIKEN at Wako, Saitama, Japan, Staff Scientist
• From 1998, To 1999

  National Institute of Neuroscience, Tokyo, Japan, Research Fellow
• From 1997, To 1998

  National Institute of Neuroscience, Tokyo, Japan, Department of Neurology Research Resident, Graduate School of Medicine, Kyoto University, Kyoto, Japan, Laboratory for Neuropathology, University Medical School of Pecs, Hungary, Research Fellow
• From 1993, To 1997

  Department of Neurology, Sumitomo Hospital, Osaka, Japan, Resident
• From 1992, To 1993

  Department of Neurology, Kyoto University Hospital, Kyoto, Japan, Resident
• From 1992

  Kyoto University, Graduate School of Medicine, Kyoto, Japan (Master's Program)

Language of Instruction

• Japanese
• English

ID,URL

• J-Global ID

  201101014111670665

• External link

  http://www.cira.kyoto-u.ac.jp/inoue/

Website(s) (URL(s))

• http://www.cira.kyoto-u.ac.jp/inoue/e/
• https://www.scopus.com/authid/detail.uri?authorId=55461444200

researchmap URL

• https://researchmap.jp/InoueH

Research

Research Topics, Overview of the research

• Research Topics

  Neurological disease research using reprogramming technology and data science

• Overview of the research

  In this research field, we are engaged in "neurological disease research using reprogramming technology and data science”.
  It is our dream to find a cure for irremediable neurological diseases with the power of science. We are innovating reprogramming-based research by its merger with the power of artificial intelligence and thereby challenging to reveal the mysterious reasons why neurodegeneration occurs, and to explore the question of what a human being is.
  
  We are working on the following projects:
  -Research on the pathogenesis and treatment of neurological diseases including ALS and Alzheimer’s disease
  -Neurodegeneration Research using machine learning
  -Research on brain intelligence using primate stem cells
  
  We start with the thought "I wish I could do this, know this, and try this”. A “dream-driven approach” is the style of our laboratory.
  

Research Areas

• Life sciences, Neuroscience - general
• Life sciences, Medical biochemistry

Papers

• Phototoxicity avoidance is a potential therapeutic approach for retinal dystrophy caused by EYS dysfunction.

  Yuki Otsuka; Keiko Imamura; Akio Oishi; Kazuhide Asakawa; Takayuki Kondo; Risako Nakai; Mika Suga; Ikuyo Inoue; Yukako Sagara; Kayoko Tsukita; Kaori Teranaka; Yu Nishimura; Akira Watanabe; Kazuhiro Umeyama; Nanako Okushima; Kohnosuke Mitani; Hiroshi Nagashima; Koichi Kawakami; Keiko Muguruma; Akitaka Tsujikawa; Haruhisa Inoue

  JCI insight, 22 Apr. 2024

  
• Protocol for a phase 2 study of bosutinib for amyotrophic lateral sclerosis using real-world data: induced pluripotent stem cell-based drug repurposing for amyotrophic lateral sclerosis medicine (iDReAM) study.

  Keiko Imamura; Yuishin Izumi; Naohiro Egawa; Takashi Ayaki; Makiko Nagai; Kazutoshi Nishiyama; Yasuhiro Watanabe; Takenobu Murakami; Ritsuko Hanajima; Hiroshi Kataoka; Takao Kiriyama; Hitoki Nanaura; Kazuma Sugie; Takehisa Hirayama; Osamu Kano; Masahiro Nakamori; Hirofumi Maruyama; Shotaro Haji; Koji Fujita; Naoki Atsuta; Harutsugu Tatebe; Takahiko Tokuda; Naoto Takahashi; Akiko Morinaga; Riko Tabuchi; Motoki Oe; Mihoko Kobayashi; Kasia Lobello; Satoshi Morita; Gen Sobue; Ryosuke Takahashi; Haruhisa Inoue

  BMJ open, 26 Oct. 2024, Peer-reviewed

  Access this paper :

  
• iPSC screening identifies CACNA2D2 as a potential therapeutic target for FTLD-Tau.

  Keiko Imamura; Ayako Nagahashi; Aya Okusa; Tomoki Sakasai; Kayoko Tsukita; Yumiko Kutoku; Yutaka Ohsawa; Yoshihide Sunada; Naruhiko Sahara; Nicholas M Kanaan; Makoto Higuchi; Kohji Mori; Manabu Ikeda; Haruhisa Inoue

  European journal of cell biology, 21 Mar. 2025

  
• Striosome circuitry stimulation inhibits striatal dopamine release and locomotion

  Taro Okunomiya; Dai Watanabe; Haruhiko Banno; Takayuki Kondo; Keiko Imamura; Ryosuke Takahashi; Haruhisa Inoue

  The Journal of Neuroscience, 02 Dec. 2024

  
• Mutant α-synuclein causes death of human cortical neurons via ERK1/2 and JNK activation.

  Hidefumi Suzuki; Naohiro Egawa; Keiko Imamura; Takayuki Kondo; Takako Enami; Kayoko Tsukita; Mika Suga; Yuichiro Yada; Ran Shibukawa; Ryosuke Takahashi; Haruhisa Inoue

  Molecular brain, 05 Mar. 2024

  Access this paper :

  
• Development of biomarkers specific for Alzheimer's disease subgroups

  Iwata, Nobuhisa; Matsuo, Kazuya; Ohtsuki, Sumio; Asai, Masashi; Kondo, Takayuki; Inoue, Haruhisa; Shirotani, Keiro

  Journal of Pharmacological Sciences, 2017

  

Awards

• 06 Jan. 2014

  Center for iPS Cell Research and Application, Kyoto University, CiRA Award
• 16 Apr. 2015

  Yomiuri Techno Forum, 21st Yomiuri Techno Forum Gold Medal
• 10 Feb. 2016

  Japan Research Foundation for Clinical Pharmacology, 8th Japan Research Foundation for Clinical Pharmacology Research Award
• 06 Jan. 2021

  Center for iPS Cell Research and Application, Kyoto University, The 8th CiRA Award

External funds: Kakenhi

• Immune response to intranasal tau vaccine in the brain and the use of nanoparticles as vectors

  Grant-in-Aid for Scientific Research (B)

  Basic Section 51030:Pathophysiologic neuroscience-related

  Kyoto University

  Haruhisa Inoue

  From 01 Apr. 2021, To 31 Mar. 2024, Project Closed

  タウワクチン;脳内免疫応答;ナノ粒子;シングルセル解析;タウオパチー;点鼻ワクチン;ウイルスベクター

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H02807/
• Imaging studies of neurodegeneration by deep learning

  Grant-in-Aid for Challenging Research (Exploratory)

  Studies on the Super-Aging Society

  Kyoto University

  Inoue Haruhisa

  From 29 Jun. 2018, To 31 Mar. 2021, Project Closed

  ALS;Deep Learning;超早期病態;診断;データサイエンス;Deep learning;deep learning;神経変性;超高齢社会;アルツハイマー病;iPS細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K18452/
• In vivo reprogramming for ALS regenerative therapy

  Grant-in-Aid for Scientific Research (B)

  Basic Section 51030:Pathophysiologic neuroscience-related

  Kyoto University

  Inoue Haruhisa

  From 01 Apr. 2018, To 31 Mar. 2021, Project Closed

  ALS;生体内ダイレクトリプログラミング;運動神経細胞;再生医療;ウイルスベクター;ダイレクトリプログラミング;細胞移植;神経再生

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02717/
• Creation of ALS treatment seed by latest comprehensive neuroscience research for Kii ALS/PDC

  Grant-in-Aid for Scientific Research (B)

  Wakayama Medical University

  Hidefumi Ito

  From 01 Apr. 2015, To 31 Mar. 2018, Project Closed

  筋萎縮性側索硬化症;パーキンソン認知症複合;紀伊半島;タウタンパク;TDP-43;ポリユビキチン;神経科学;ポリユビキチン鎖;タンパク分解系;神経炎症;神経病理;遺伝子解析

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04270/
• Establishment of canine iPS cells for the study of disease-model dogs

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Junya TOGUCHIDA

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  iPS細胞;イヌ;疾患モデル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24659675/
• Understanding the neuronal dysfunction/neurocircuit pathology based on iPSC technology

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Biological Sciences

  Kyoto University

  Haruhisa INOUE

  From 01 Apr. 2010, To 31 Mar. 2015, Project Closed

  脳神経疾患;脳・神経;神経科学

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-22110007/
• Drug development for ALS using astrocytes derived from patient-specific iPSCs

  Grant-in-Aid for Scientific Research (C)

  Kyoto University

  Haruhisa INOUE

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  神経内科学;神経科学;幹細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21591079/
• The analysis of participation in the ubiquitin proteasome system for understanding the mechanisms of neurodegenerative diseases.

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Ryosuke TAKAHASHI

  From 01 Apr. 2008, To 31 Mar. 2011, Project Closed

  ALS;運動ニューロン;プロテアソーム;Rpt3;コンディショナルノックアウト;神経変性疾患;モデル動物;パーキンソン病;筋萎縮性側索硬化症;RP t 3;26Sプロテアソーム;コンディショナルノックアウトマウス;VAChT-Cre;アルツハイマー病;タンパク分解;Cre-lox system

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390244/
• パエル受容体のドーパミンニューロンの機能維持と変性における役割の解明

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Kyoto University

  高橋 良輔

  From 01 Apr. 2008, To 31 Mar. 2010, Project Closed

  パーンソン病;Parkin;小胞体ストレス;ATF6α;遺伝子ノックアウトマウス;MEF;アデノウイルス;パーキンソン病;AR-JP;PARK 2;ユビキチンリガーゼ;Pael-R;ノルアドレナリン;NET

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20023015/
• Elucidation of the fumctional network among the genes for familial Parkinson disease

  Grant-in-Aid for Scientific Research (B)

  Kyoto University

  Ryosuke TAKAHASHI

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  PINK1;Parkin;Omi;HtrA2;Lewy小体;Hsp90;cdc37;PACRG;Glup;小胞体ストレス;α-シヌクレイン;トランスジェニックマウス;BAC;行動解析;メダカ;ENU;PARK4;PARK6, PINK1;Parkin;Omi;HtrA2;Lewy body;Hsp90;cdc37;Glup;PARCG;ER stress

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390255/
• 抗アポトーシス分子を用いた筋萎縮性側索硬化症の治療法に関する研究

  Grant-in-Aid for Young Scientists (B)

  The Institute of Physical and Chemical Research

  井上 治久

  From 01 Apr. 2003, To 31 Mar. 2006, Project Closed

  ALS;apoptosis;Caspase-9;XIAP;p35;SOD1

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15790459/
• 抗アポトーシス分子を用いた筋萎縮性側索硬化症の治療法に関する研究

  Grant-in-Aid for Young Scientists (B)

  特殊法人理化学研究所

  井上 治久

  From 01 Apr. 2001, To 31 Mar. 2003, Project Closed

  ALS;SOD1マウス;アポトーシス;XIAP;治療;カスパーゼ;アポトーシス阻害タンパク;コリンアセチルトランスフェレースプロモーター;ALSモデルマウス;神経細胞死

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13770333/

External funds: others

• 難治性疾患政策研究事業 (2024年度分)

  厚生労働省, 厚生労働科学研究費補助金

  From 01 Apr. 2024, To 31 Mar. 2025

  研究分担者
• 難治性疾患政策研究事業 (2022年度分)

  厚生労働省, 厚生労働科学研究費補助金

  From 01 Apr. 2022, To 31 Mar. 2023

  研究分担者
• 難治性疾患政策研究事業 (2021年度分)

  厚生労働省, 厚生労働科学研究費補助金

  From 01 Apr. 2021, To 31 Mar. 2022

  分担
• 患者レジストリを活用した筋萎縮性側索硬化症治療薬開発のための第2相医師主導治験

  臨床研究・治験推進研究事業

  From 2021, To 2024
• 筋萎縮性側索硬化症（ALS）に対する遺伝子治療法の開発, 難治性疾患実用化研究事業

  From 2020, To 2023
• 高品質な分化細胞・組織を用いた神経系および視覚系難病のin vitroモデル化と治療法の開発

  再生医療実現拠点ネットワークプログラム「疾患特異的iPS 細胞を活用した難病研究」

  From 2012, To 2015

  代表
• ドラックリポジショニングによるALS治療薬開発のための薬物動態評価

  平成30年度 再生医療実用化研究事業（二次公募）

  From 2018, To 2019

  代表
• 患者レジストリを活用した筋萎縮性側索硬化症治療薬開発のための医師主導治験

  平成30年度 臨床研究・治験推進研究事業（一次公募）

  From 2018, To 2020

  代表
• 初期化メカニズムの解明、安全性の確立

  平成30年度再生医療実現拠点ネットワークプログラム　再生医療用iPS 細胞ストック開発拠点

  From 2018, To 2019

  分担
• 「人工多能性幹細胞（iPS細胞）作製・制御等の医療基盤技術」研究領域 iPS細胞を駆使した神経変性疾患病因機構の解明と個別化予防医療開発

  科学技術振興機構　戦略的創造研究推進事業 CREST

  From 2009, To 2015

  代表
• タウオパチー型認知症の治療とモニタリング技術の開発

  分子イメージング研究プログラム　独立行政法人　科学技術振興機構

  From 2007, To 2009

  代表
• iPS細胞を利用した創薬研究支援事業

  医療施設運営費等補助金（臨床研究拠点等整備事業）

  From 2012, To 2012

  代表
• パーキンソン病および類縁疾患患者iPS細胞を用いた病態解明

  厚生労働省厚生労働科学研究費補助金（難治性疾患克服研究事業）

  From 2009, To 2009

  分担
• 難治性疾患創薬シーズの探索と薬剤安全性評価法の開発

  厚生労働省科学研究費補助金（難病・がん等の疾患分野の医療の実用化研究事業）

  From 2013, To 2018

  代表
• 疾患特異的iPS細胞を用いた難治性疾患の画期的診断・治療法に関する研究

  厚生労働科学研究費補助金（難治性疾患克服研究事業）

  From 2009, To 2011

  分担
• ジストニアの分子病態解明と新規治療法開発

  平成26年度厚生労働科学研究委託費（難治性疾患等実用化研究事業）

  From 2014, To 2014

  分担
• 筋萎縮性側索硬化症モデルマウスにおけるボスチニブ有効血中濃度の同定

  平成29年度第二期GAPファンドプログラム

  From 2017, To 2018

  代表
• タウタンパク質を標的とした認知症治療薬の開発

  平成30年度京都大学「橋渡し研究戦略的推進プログラム」シーズA

  From 2018, To 2019

  代表
• 京都大学iPS細胞研究統合推進拠点　ヒトiPS細胞を用いた神経再生医療実現化のための技術開発

  文部科学省　再生医療の実現化プロジェクト

  From 2010, To 2012

  分担
• 精神・神経疾患のiPS細胞を用いた診断・治療法の開発に関する戦略的研究

  精神・神経疾患研究開発費研究事業

  From 2012, To 2014

  分担

Education

Teaching subject(s)

• From 01 Apr. 2025, To 31 Mar. 2026

  Introduction to iPS cell/regenerative medicine

  3237, Fall, Faculty of Medicine, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to iPS cell/regenerative medicine

  3237, Fall, Faculty of Medicine, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to iPS cell/regenerative medicine

  3237, Fall, Faculty of Medicine, 1

Participation in PhD Defense

• Cell transplantation-mediated dystrophin supplementation efficacy in Duchenne muscular dystrophy mouse motor function improvement demonstrated by enhanced skeletal muscle fatigue tolerance

  CLEMENCE KIHO YOSHIOKA, Graduate School of Medicine, Sub-chief Examiner

  24 Mar. 2025
• Time-window of offline long-term potentiation in anterior cingulate cortex during memory consolidation and recall

  LIU JUNYU, Graduate School of Medicine, Sub-chief Examiner

  24 Mar. 2025
• The inhibitory effects of Orengedokuto on inducible PGE2 production in BV-2 microglial cells

  IWATA YOSHIKA, Graduate School of Medicine, Sub-chief Examiner

  23 May 2024
• Transplantation of autologous bone marrow-derived mononuclear cells into cerebrospinal fluid in a canine model of spinal cord injury

  NAKAMOTO YUYA, Graduate School of Medicine, Chief Examiner

  24 Mar. 2025
• A novel mouse model for investigating α-synuclein aggregates in oligodendrocytes: implications for the glial cytoplasmic inclusions in multiple system atrophy

  ISHIMOTO TOMOYUKI, Graduate School of Medicine, Chief Examiner

  24 Sep. 2024
• Involvement of mTOR pathway in neurodegeneration in NSF-related developmental and epileptic encephalopathy

  HAYASHI TAKAHIRO, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Efficacy of oligodendrocyte precursor cells as delivery vehicles for single-chain variable fragment to misfolded SOD1 in ALS rat model

  MINAMIYAMA SUMIO, Graduate School of Medicine, Chief Examiner

  24 Jul. 2023
• GPCR-mediated calcium and cAMP signaling determines psychosocial stress susceptibility and resiliency

  INABA HIROMICHI, Graduate School of Medicine, Sub-chief Examiner

  24 Jul. 2023
• Acute inhibition of AMPA receptors by perampanel reduces amyloid β-protein levels by suppressing β-cleavage of APP in Alzheimer’s disease models

  UEDA SAKIHO, Graduate School of Medicine, Chief Examiner

  25 Mar. 2024
• Establishment of quantitative and consistent in vitro skeletal muscle pathological models of myotonic dystrophy type 1 using patient-derived iPSCs

  KAWADA RYU, Graduate School of Medicine, Chief Examiner

  25 Mar. 2024
• Association of Cortical Superficial Siderosis with Post-Stroke Epilepsy

  TANAKA TOMOTAKA, Graduate School of Medicine, Sub-chief Examiner

  23 May 2023
• Long-Term Outcome of Sciatic Nerve Regeneration Using　Bio3D Conduit Fabricated from Human Fibroblasts in a Rat Sciatic Nerve Model

  ANDO MAKI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Preferential arborization of dendrites and axons of parvalbumin- and somatostatin-positive GABAergic neurons within subregions of the mouse claustrum

  TAKAHASHI MEGUMU, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Automated measurement of fluorescence signals reveals a significant increase of the graft-derived　neurite extension in neonates compared to aged rats

  GRINAND LUC BRICE, Graduate School of Medicine, Chief Examiner

  26 Sep. 2022
• Rapid induction of dopaminergic neuron loss accompanied by Lewy body-like inclusions in A53T BAC-SNCA transgenic mice

  OKUDA SHINYA, Graduate School of Medicine, Chief Examiner

  23 May 2022
• Lewy body disease primate model with α-synuclein propagation from the olfactory bulb

  SAWAMURA　MASANORI, Graduate School of Medicine, Chief Examiner

  23 Jan. 2023
• Histone Deacetylase 2 Knockdown Ameliorates Morphological Abnormalities of Dendritic Branches and Spines to Improve Synaptic Plasticity in an APP/PS1 Transgenic Mouse Model

  NAKATSUKA DAIKI, Graduate School of Medicine, Sub-chief Examiner

  26 Sep. 2022
• Perampanel Inhibits α-Synuclein Transmission in Parkinson’s Disease Models

  UEDA JUN, Graduate School of Medicine, Chief Examiner

  23 Mar. 2022
• A Biomarker for Benign Adult Familial Myoclonus Epilepsy: High-Frequency Activities in Giant Somatosensory Evoked Potentials

  TOJIMA MAYA, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• Establishment of a heart‐on‐a‐chip microdevice based on human iPS cells for the evaluation of human heart tissue function

  Abulaiti Mosha, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2022
• The stimulator of interferon genes (STING) pathway is upregulated in striatal astrocytes of patients with multiple system atrophy

  INOUE YUTAKA, Graduate School of Medicine, Chief Examiner

  23 Mar. 2022
• The Uncinate Fasciculus as a Predictor of Conversion from aMCI to Alzheimer Disease(健忘型軽度認知機能障害からアルツハイマー病への移行予測因子としての鉤状束)

  谷口　和子, Chief Examiner

  23 Mar. 2015
• Early pathogenesis of Duchenne muscular dystrophy modelled in patient-derived human induced pluripotent stem cells.(デュシェンヌ型筋ジストロフィー患者由来iPS細胞を用いた初期病態再現)

  庄子　栄美, Sub-chief Examiner

  23 Jul. 2015
• BRIDGING A 30 MM DEFECT IN THE CANINE ULNAR NERVE USING VESSEL-CONTAINING CONDUITS WITH IMPLANTATION OF BONE MARROW STROMAL CELLS(骨髄間葉系細胞移植を行った血管含有神経導管によるイヌ尺骨神経30mm欠損の再建)

  貝澤　幸俊, Sub-chief Examiner

  25 Jan. 2016
• Amyotrophic lateral sclerosis models derived from human embryonic stem cells with different superoxide dismutase 1 mutations exhibit differential drug responses(ヒト胚性幹細胞由来筋萎縮性側索硬化症モデル細胞はSOD1変異の違いにより異なる薬剤反応性を示す)

  磯部　武久, Chief Examiner

  23 Mar. 2016
• The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease(アストロサイトから放出されたインスリン様成長因子結合タンパク質３型のアルツハイマー病理への関与)

  渡邉　究, Chief Examiner

  23 Mar. 2016
• CUL2-mediated clearance of misfolded TDP-43 is paradoxically affected by VHL in oligodendrocytes in ALS(ミスフォールド型TDP-43のCUL2依存性分解機構におけるVHL蛋白質の相反的機能と、ALSのオリゴデンドロサイト細胞質封入体形成の関連について)

  内田　司, Sub-chief Examiner

  25 Jul. 2016
• Purification of functional human ES and iPSC-derived midbrain dopaminergic progenitors using LRTM1(LRTM1を用いたヒトES/iPS細胞由来機能的ドパミン神経前駆細胞の純化)

  佐俣　文平, Sub-chief Examiner

  23 Mar. 2017
• We could predict good responders to vagus nerve stimulation: a surrogate marker by slow cortical potential shift(脳波の緩電位変化は迷走神経刺激療法の治療効果の代替マーカーとなる)

  BAYASGALAN BORGIL, Sub-chief Examiner

  24 Nov. 2017
• Stimulus-driven changes in the direction of neural priming during visual word recognitioｎ(視覚単語認識における神経プライミングの刺激誘導性変化)

  ＭＡＣＩＥＪ　ＷＡＬＤＥＭＡＲ　ＰＡＳ, Sub-chief Examiner

  25 Sep. 2017
• Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy(Duchenne型筋ジストロフィーに対して変異ジストロフィンエキソンのスキッピング誘導活性を有する経口投与可能な新規CLK1阻害剤の開発)

  佐古　有季哉, Chief Examiner

  24 Jul. 2017
• Enhanced Axonal Extension of Subcortical Projection Neurons Isolated from Murine Embryonic Cortex using Neuropilin-1(Neuropilin-1を用いて胎児マウスの大脳皮質から選別したSubcortical Projection Neuronは移植後により多くの軸索を伸展させる)

  佐野　徳隆, Chief Examiner

  23 Jan. 2018
• Status epilepticus in the elderly: Prognostic implications of rhythmic and periodic patterns in electroencephalography and hyperintensities on diffusion-weighted imaging(高齢者のてんかん重積状態：脳波上の律動性および周期性パターンと拡散強調画像における高信号の予後的意義)

  吉村　元, Sub-chief Examiner

  25 Sep. 2017
• Long-term expansion of alveolar stem cells derived from human iPS cells in organoids(オルガノイド形成下におけるヒトiPS細胞由来肺胞幹細胞の長期培養)

  山本　佑樹, Sub-chief Examiner

  26 Mar. 2018
• Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell－engineered heart tissue（ヒトiPS細胞による三次元心臓組織を用いたTorsade de Pointes(トルサード・ド・ポアント）型不整脈の再現）

  川東　正英, Chief Examiner

  26 Mar. 2018
• Brainstem tau pathology in Alzheimer’s disease is characterized by increase of three repeat tau and independent of amyloid β(脳幹におけるアルツハイマー病のタウ病変は、3リピート型タウの増加を特徴とし、アミロイドβ蓄積から独立して存在する)

  植松　未帆, Chief Examiner

  26 Mar. 2018
• Generation of thalamic neurons from mouse embryonic stem cells(マウス胚性幹細胞からの視床神経の分化誘導)

  白石　敦士, Sub-chief Examiner

  23 Jan. 2018
• Elimination of TDP-43 inclusions linked to amyotrophic lateral sclerosis by a misfolding-specific intrabody with dual proteolytic signals(分解型細胞内抗体によるTDP-43凝集体の除去効果)

  玉木　良高, Chief Examiner

  25 Sep. 2018
• Establishment of immunodeficient retinal degeneration model mice and functional maturation of human ESC-derived retinal sheets after transplantation(免疫不全・網膜変性マウスモデルの作製とヒトES細胞由来網膜シート移植後の機能的成熟)

  伊良波　諭, Sub-chief Examiner

  23 Jan. 2019
• The efficacy of a scaffold-free Bio 3D conduit developed from human fibroblasts on peripheral nerve regeneration in a rat sciatic nerve model(ラット坐骨神経モデルにおけるヒト線維芽細胞を用いたscaffold-free Bio 3D conduitの末梢神経再生に対する有効性)

  淘江　宏文, Sub-chief Examiner

  25 Mar. 2019
• Critical Functionality Effects from Storage Temperature on Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium Cell Suspensions(ヒトiPS細胞由来網膜色素上皮細胞懸濁液の非凍結条件下における保存温度の影響)

  北畑　将平, Sub-chief Examiner

  25 Mar. 2019
• Transplantation of feeder-free human induced pluripotent stem cell-derived　cortical neuron progenitors in adult male Wistar rats with focal brain ischemia(フィーダーフリー環境で誘導されたヒト多能性幹細胞由来大脳皮質神経細胞の成体雄ウィスターラット局所脳虚血モデルへの移植)

  ＹＵＬＩＵＳ　ＨＥＲＭＡＮＴＯ, Sub-chief Examiner

  25 Mar. 2019
• Low body mass index and life prognosis in Parkinson’s disease(パーキンソン病患者の低BMIと生命予後の関係)

  朴　貴瑛, Chief Examiner

  23 Mar. 2020
• GBA haploinsufficiency accelerates alpha synuclein pathology with altered lipid metabolism in a prodromal model of Parkinson’s disease(パーキンソン病の前駆期モデルにおいて、GBAのハプロ不全は脂質代謝変化を通してアルファシヌクレイン病理を加速させる)

  生野　真嗣, Chief Examiner

  23 Jul. 2019
• Human pluripotent stem cell-derived tumor model uncovers the embryonic stem cell signature as a key driver in atypical teratoid/rhabdoid tumor(ヒトiPS細胞由来脳腫瘍モデルによる非定型奇形腫様/ラブドイド腫瘍発生の主要因子となる胚性幹細胞様遺伝子発現の同定)

  寺田　行範, Sub-chief Examiner

  23 Jul. 2019
• Verification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model(iPS細胞モデルを用いたセッケル症候群関連ATR遺伝子変異の細胞種特異的スプライシングの確認及び矯正)

  市島　ホセ, Chief Examiner

  23 Jul. 2019
• Development of a stent capable of the controlled release of　basic fibroblast growth factor and argatroban to treat cerebral aneurysms: In vitro experiment and evaluation in a rabbit aneurysm model(basic fibroblast growth factor及びアルガトロバンの徐放作用を有する脳動脈瘤治療用ステントの開発：In vitro研究とウサギ動脈瘤モデルでの評価)

  新井　大輔, Sub-chief Examiner

  24 Sep. 2019
• Doxorubicin-Immersed Skeletal Muscle Grafts Promote Peripheral Nerve Regeneration Across a 10‐mm Defect in the Rat Sciatic Nerve(ドキソルビシン浸透前処置した筋組織グラフトはラット坐骨神経10ｍｍ欠損モデルにて神経再生を促進する)

  竹内　久貴, Chief Examiner

  23 Mar. 2020
• MicroRNA-based separation of cortico-fugal projection neuron-like cells derived from embryonic stem cells(マイクロRNAスイッチを用いた胎児幹細胞由来神経細胞からの皮質投射ニューロンの選別法の開発)

  春原　匡, Sub-chief Examiner

  23 Mar. 2020
• Phosphorylated NF-κB subunit p65 aggregates in granulovacuolar degeneration and neurites in neurodegenerative diseases with tauopathy(タウオパチーを伴う神経変性疾患における顆粒空胞変性および神経突起におけるリン酸化NF-κBサブユニットp65の凝集体)

  山口　裕子, Chief Examiner

  23 Mar. 2020
• 6-Deoxyjacareubin, a natural compound preventing hypoxia-induced cell death, ameliorates neurodegeneration in a mouse model of familial amyotrophic lateral sclerosis(低酸素による細胞死を抑制する天然化合物6-deoxyjacareubinによる家族性筋萎縮性側索硬化症モデルの神経保護効果)

  星野　友則, Chief Examiner

  25 May 2020
• Synaptic vesicle protein 2B negatively regulates the amyloidogenic processing of AβPP as a novel interaction partner of BACE1(新規BACE1結合蛋白であるシナプス小胞蛋白2BはBACE1によるアミロイド前駆体蛋白の切断を抑制的に制御する)

  宮本　将和, Sub-chief Examiner

  27 Jul. 2020
• Eicosapentaenoic acid prevents the progression of intracranial aneurysms in rats(エイコサペンタエン酸はラットにおいて脳動脈瘤の増大を抑制する)

  安部倉　友, Chief Examiner

  24 Nov. 2020
• Zonisamide promotes survival of human induced pluripotent stem cell-derived dopaminergic neurons in the striatum of female rats(ゾニサミドは雌ラットの線条体においてヒトiPS細胞由来ドパミン作動性神経細胞の生存を促進する)

  宮脇　良文, Sub-chief Examiner

  24 Nov. 2020
• Axonal Extensions along Corticospinal Tracts from Transplanted Human Cerebral Organoids(ヒト大脳オルガノイド移植による皮質脊髄路に沿った軸索伸展)

  北原　孝宏, Sub-chief Examiner

  25 Jan. 2021
• Initiation of Supporting Cell Activation for Hair Cell Regeneration in the Avian Auditory Epithelium: An Explant Culture Model(鳥類蝸牛器官培養モデルでの有毛細胞再生における支持細胞活性化因子の初期過程)

  松永　麻美, Sub-chief Examiner

  23 Mar. 2021
• Exercise Promotes Neurite Extensions from Grafted Dopaminergic Neurons in the Direction of the Dorsolateral Striatum in Parkinson’s Disease Model Rats(運動負荷はパーキンソン病モデルラットにおいて移植されたドーパミンニューロンの軸索を線条体背外側へ誘導する)

  取越　貞治, Sub-chief Examiner

  23 Mar. 2021
• CaMKII activation triggers persistent formation and segregation of postsynaptic liquid phase(CaMKIIの活性化によるシナプス後部液相の持続的な形成と分離)

  劉　品吾, Sub-chief Examiner

  23 Mar. 2021
• Translocator protein (TSPO) and stress cascades in mouse models of psychosis with inflammatory disturbances(炎症反応を呈し精神病様行動異常を示すモデルマウスにおけるトランスロケータータンパク質（TSPO）およびストレスカスケード)

  福留　大輔, Chief Examiner

  24 Nov. 2020

Administration

School management (title, position)

• From 01 Apr. 2025, To 31 Mar. 2027

  組換えDNA実験安全委員会 委員

Faculty management (title, position)

• From 01 Apr. 2024

  iPS細胞研究所 副所長
• From 01 Apr. 2024

  管理運営委員会
• From 01 Apr. 2024

  教員表彰選考委員会
• From 01 Apr. 2024

  教員業績評価委員会
• From 26 May 2022, To 31 Mar. 2026

  創薬技術開発室運営委員会
• From 01 Apr. 2022

  自己点検・評価委員会
• From 01 Apr. 2022

  京都大学医生物学研究所医の倫理委員会、委員
• From 01 Apr. 2022

  Head of Department of Fundamental Cell Technology
• From 01 Apr. 2010

  組換えDNA実験安全委員会1号委員、委員長
• From 01 Apr. 2012

  安全衛生委員会1号委員、衛生管理者
• From 01 Apr. 2015, To 31 Mar. 2022

  発明委員会1号委員