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Furukawa, Ayako

Graduate School of Agriculture, Division of Applied Life Sciences Associate Professor

Furukawa, Ayako
list
    Last Updated :2024/12/03

    Basic Information

    Faculty

    • Faculty of Agriculture

    Email Address

    • Email Address

      furukawa.ayako.5wkyoto-u.ac.jp

    Professional Memberships

    • To Present
      日本生物物理学会

    Academic Degree

    • 20 Mar. 2004
      東京理科大学修士(理学)
    • 20 Mar. 2007
      東京理科大学博士(理学)

    Academic Resume (Graduate Schools)

    • 東京理科大学, 大学院理学研究科化学専攻博士後期課程, 修了
    • 東京理科大学, 大学院理学研究科博士後期課程化学専攻, 修了
    • 東京理科大学, 大学院理学研究科化学専攻博士前期課程, 修了
    • 東京理科大学, 大学院理学研究科博士前期課程化学専攻, 修了

    Academic Resume (Undergraduate School/Majors)

    • 東京理科大学, 理学部応用化学科, 卒業

    ID,URL

    researchmap URL

    list
      Last Updated :2024/12/03

      Research

      Research Topics, Overview of the research

      • Research Topics

        生体高分子の天然変性領域の構造揺らぎに着目し、ヌクレオソームやヌクレオソーム結合タンパク質にエピジェネティックな修飾が入った際の構造変化を原子レベルで解析することによって、遺伝子発現調節機構を解明することを目指しています。

      Research Interests

      • 構造生物学

      Research Areas

      • Life sciences, Structural biochemistry

      Papers

      • Bipartite binding interface recruiting HP1 to chromosomal passenger complex at inner centromeres.
        Kosuke Sako; Ayako Furukawa; Ryu-Suke Nozawa; Jun-Ichi Kurita; Yoshifumi Nishimura; Toru Hirota
        The Journal of cell biology, 02 Sep. 2024
      • H2A ubiquitination alters H3-tail dynamics on linker-DNA to enhance H3K27 methylation
        Hideaki Ohtomo; Shinsuke Ito; Nicholas J. McKenzie; Michael Uckelmann; Masatoshi Wakamori; Haruhiko Ehara; Ayako Furukawa; Yasuo Tsunaka; Marika Shibata; Shun-ichi Sekine; Takashi Umehara; Chen Davidovich; Haruhiko Koseki; Yoshifumi Nishimura
        Journal of Molecular Biology, Jan. 2023
      • Histone tail network and modulation in a nucleosome.
        Yasuo Tsunaka; Ayako Furukawa; Yoshifumi Nishimura
        Current opinion in structural biology, 18 Jul. 2022
      • Characteristic H3 N-tail dynamics in the nucleosome core particle, nucleosome, and chromatosome
        Ayako Furukawa; Masatoshi Wakamori; Yasuhiro Arimura; Hideaki Ohtomo; Yasuo Tsunaka; Hitoshi Kurumizaka; Takashi Umehara; Yoshifumi Nishimura
        iScience, Mar. 2022
      • Structural dynamics of double-stranded DNA with epigenome modification.
        Ayako Furukawa; Erik Walinda; Kyohei Arita; Kenji Sugase
        Nucleic acids research, 18 Dec. 2020
      • Acetylated histone H4 tail enhances histone H3 tail acetylation by altering their mutual dynamics in the nucleosome.
        Ayako Furukawa; Masatoshi Wakamori; Yasuhiro Arimura; Hideaki Ohtomo; Yasuo Tsunaka; Hitoshi Kurumizaka; Takashi Umehara; Yoshifumi Nishimura
        Proceedings of the National Academy of Sciences of the United States of America, 18 Aug. 2020, Peer-reviewed
      • Author Correction: Identification of a binding protein for sesamin and characterization of its roles in plant growth.
        Masayuki Tera; Tomotsugu Koyama; Jun Murata; Ayako Furukawa; Shoko Mori; Toshiaki Azuma; Takehiro Watanabe; Katsuhito Hori; Atsushi Okazawa; Yasuaki Kabe; Makoto Suematsu; Honoo Satake; Eiichiro Ono; Manabu Horikawa
        Scientific reports, 28 May 2020
      • Author Correction: Identification of a binding protein for sesamin and characterization of its roles in plant growth.
        Masayuki Tera; Tomotsugu Koyama; Jun Murata; Ayako Furukawa; Shoko Mori; Toshiaki Azuma; Takehiro Watanabe; Katsuhito Hori; Atsushi Okazawa; Yasuaki Kabe; Makoto Suematsu; Honoo Satake; Eiichiro Ono; Manabu Horikawa
        Scientific reports, 07 May 2020
      • Identification of a binding protein for sesamin and characterization of its roles in plant growth.
        Masayuki Tera; Tomotsugu Koyama; Jun Murata; Ayako Furukawa; Shoko Mori; Toshiaki Azuma; Takehiro Watanabe; Katsuhito Hori; Atsushi Okazawa; Yasuaki Kabe; Makoto Suematsu; Honoo Satake; Eiichiro Ono; Manabu Horikawa
        Scientific reports, 14 Jun. 2019, Peer-reviewed
      • Quantitative analysis of protein-ligand interactions by NMR
        Ayako Furukawa; Tsuyoshi Konuma; Saeko Yanaka; Kenji Sugase
        PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY, Aug. 2016, Peer-reviewed
      • Dynamic changes in CCAN organization through CENP-C during cell-cycle progression
        Harsh Nagpal; Tetsuya Hori; Ayako Furukawa; Kenji Sugase; Akihisa Osakabe; Hitoshi Kurumizaka; Tatsuo Fukagawa
        MOLECULAR BIOLOGY OF THE CELL, Nov. 2015, Peer-reviewed
      • Dynamic changes in CCAN organization through CENP-C during cell-cycle progression
        Nagpal H; Hori T; Furukawa A; Sugase K; Osakabe A; Kurumizaka H; Fukagawa T
        Mol Cell Biol, Nov. 2015, Peer-reviewed
      • Quantitative Analysis of Location- and Sequence-Dependent Deamination by APOBEC3G Using Real-Time NMR Spectroscopy
        Ayako Furukawa; Kenji Sugase; Ryo Morishita; Takashi Nagata; Tsutomu Kodaki; Akifumi Takaori-Kondo; Akihide Ryo; Masato Katahira
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Feb. 2014, Peer-reviewed
      • Quantitative analysis of location- and sequence-dependent deamination by APOBEC3G using real-time NMR spectroscopy.
        Furukawa A; Sugase K; Morishita R; Nagata T; Kodaki T; Takaori-Kondo A; Ryo A; Katahira M
        Angew Chem Int Ed Engl, Feb. 2014, Peer-reviewed
      • Molecular and enzymatic characterization of XMRV protease by a cell-free proteolytic analysis
        Satoko Matsunaga; Tatsuya Sawasaki; Hirotaka Ode; Ryo Morishita; Ayako Furukawa; Ryuta Sakuma; Wataru Sugiura; Hironori Sato; Masato Katahira; Akifumi Takaori-Kondo; Naoki Yamamoto; Akihide Ryo
        JOURNAL OF PROTEOMICS, Aug. 2012, Peer-reviewed
      • NMR study of xenotropic murine leukemia virus-related virus protease in a complex with amprenavir
        Ayako Furukawa; Hideyasu Okamura; Ryo Morishita; Satoko Matsunaga; Naohiro Kobayashi; Takahisa Ikegami; Tsutomu Kodaki; Akifumi Takaori-Kondo; Akihide Ryo; Takashi Nagata; Masato Katahira
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2012, Peer-reviewed
      • 3PT003 A study on deaminase activity of APOBEC3C by NMR(The 50th Annual Meeting of the Biophysical Society of Japan)
        Iwaoka Ryo; Kitamura Shingo; Kanba Keisuke; Furukawa Ayako; Okamura Hideyasu; Sugiura Wataru; Nagata Takashi; Iwatani Yasumasa; Katahira Masato
        Seibutsu Butsuri, 2012
      • Heat Shock Protein 70 Inhibits HIV-1 Vif-mediated Ubiquitination and Degradation of APOBEC3G
        Ryuichi Sugiyama; Hironori Nishitsuji; Ayako Furukawa; Masato Katahira; Yuichiro Habu; Hiroaki Takeuchi; Akihide Ryo; Hiroshi Takaku
        JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2011, Peer-reviewed
      • 2G1412 NMR study of XMRV protease in complex with an inhibitor(Protein: Structure 2,The 48th Annual Meeting of the Biophysical Society of Japan)
        Okamura Hideyasu; Matsunaga Tomoko; Furukawa Ayako; Sato Yusuke; Iwaoka Ryo; Nagata Takashi; Kobayashi Naohiro; Takaori Akifumi; Morishita Ryo; Ryo Akihide; Katahira Masato
        Seibutsu Butsuri, 2011
      • 1SD-06 Coupling between cytidine-deamination by APOBEC3G and its sliding along DNA with polarity as revealed with real-time monitoring by NMR(1SD Dynamical aspects of proteins by NMR,The 49th Annual Meeting of the Biophysical Society of Japan)
        Katahira Masato; Furukawa Ayako; Nagata Takashi; Takaku Hiroshi; Morishita Ryo; Takaori Akifumi; Ryo Akihide
        Seibutsu Butsuri, 2011
      • Real-time Monitoring of the Enzymatic Reaction of APOBEC3G Possessing Anti-HIV Activity
        FURUKAWA Ayako
        Seibutsu Butsuri, 25 Sep. 2010
      • 1P122 1D1255 The real-time monitoring of the enzymatic reaction of an anti-HIV factor APOBEC3G(Nucleic acid binding proteins,Oral Presentations,The 48th Annual Meeting of the Biophysical Society of Japan)
        Furukawa Ayako; Nagata Takashi; Morishita Ryo; Iwaoka Ryo; Sugiyama Ryuichi; Takaku Hiroshi; Takaori Akifumi; Ryo Akihide; Katahira Masato
        Seibutsu Butsuri, 2010
      • Structure, interaction and real-time monitoring of the enzymatic reaction of wild-type APOBEC3G
        Ayako Furukawa; Takashi Nagata; Akimasa Matsugami; Yuichirou Habu; Ryuichi Sugiyama; Fumiaki Hayashi; Naohiro Kobayashi; Shigeyuki Yokoyama; Hiroshi Takaku; Masato Katahira
        EMBO JOURNAL, Feb. 2009, Peer-reviewed
      • Structure and real-time monitoring of the enzymatic reaction of APOBEC3G which is involved in anti-HIV activity.
        Furukawa A; Nagata T; Matsugami A; Habu Y; Sugiyama R; Hayashi F; Kobayashi N; Yokoyama S; Takaku H; Katahira M
        Nucleic acids symposium series (2004), 2009, Peer-reviewed
      • Elucidation of the mode of interaction in the UP1telomerase RNAtelomeric DNA ternary complex which serves to recruit telomerase to telomeric DNA and to enhance the telomerase activity
        Takashi Nagata; Yusuke Takada; Asami Ono; Kayoko Nagata; Yuki Konishi; Takeshi Nukina; Manami Ono; Akimasa Matsugami; Ayako Furukawa; Natsuki Fujimoto; Hirokazu Fukuda; Hitoshi Nakagama; Masato Katahira
        NUCLEIC ACIDS RESEARCH, Dec. 2008, Peer-reviewed
      • NMR assignments and the identification of the secondary structure of the anti-retroviral cytidine deaminase.
        Furukawa A; Nagata T; Habu Y; Sugiyama R; Hayashi F; Yokoyama S; Takaku H; Katahira M
        Nucleic acids symposium series (2004), 2008, Peer-reviewed
      • Structural analysis of Musashi-RNA complex on the basis of long-range structural information.
        Ohyama T; Furukawa A; Mashima T; Sugiyama T; Ohgara S; Yamazaki T; Imai T; Okano H; Nagata T; Katahira M
        Nucleic acids symposium series (2004), 2008, Peer-reviewed
      • 2P-107 A simultaneous RNA-binding mode of two RNA-binding domains of Musashi-1 analyzed by paramagnetic effects, PRE, PCS, and RDC(The 46th Annual Meeting of the Biophysical Society of Japan)
        Nagata Takashi; Ohyama Takako; Furukawa Ayako; Sugiyama Takashi; Mashima Tsukasa; Imai Takao; Okano Hideyuki; Yamazaki Toshio; Katahira Masato
        Seibutsu Butsuri, 2008
      • Mutational analyses of a single-stranded telomeric DNA binding domain of fission yeast pot1: conflict with X-ray crystallographic structure.
        Hidetaka Torigoe; Naoshi Dohmae; Fumio Hanaoka; Ayako Furukawa
        Bioscience, biotechnology, and biochemistry, Feb. 2007, Peer-reviewed
      • Tetraplex structure of fission yeast telomeric DNA and unfolding of the tetraplex on the interaction with telomeric DNA binding protein Pot1
        Hidetaka Torigoe; Ayako Furukawa
        JOURNAL OF BIOCHEMISTRY, Jan. 2007, Peer-reviewed
      • Interactions with RNA/DNA of proteins involved in the regulation of transcription, translation and telomere elongation.
        Ohyama T; Furukawa A; Miyoshi T; Takada Y; Ohgara S; Hiratsuka K; Imai T; Okano H; Nakagama H; Nagata T; Katahira M
        Nucleic acids symposium series (2004), 2007, Peer-reviewed
      • Tetraplex structure of fission yeast telomeric DNA and its unfolding by the interaction with telomeric DNA binding protein Pot1.
        Furukawa A; Torigoe H
        Nucleic acids symposium series (2004), 2005, Peer-reviewed
      • 1P038 Thermodynamic properties of Specific interaction between telomere end-binding protein Pot1 and singlestranded telomeric DNA
        Furukawa A.; Torigoe H.
        Seibutsu Butsuri, 2005
      • Syntheses of four methyl-branched secondary acetates and a methyl-branched ketone as possible candidates for the female pheromone of the screwworm fly, Cochliomyia hominivorax
        A Furukawa; C Shibata; K Mori
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, May 2002, Peer-reviewed
      • Syntheses of racemic and diastereomeric mixtures of 3,7,11,15-tetramethylhentriacontane and 4,8,12,16-tetramethyidotriacontane, the cuticular tetramethylalkanes of the tsetse fly, Glossina brevipalpis
        C Shibata; A Furukawa; K Mori
        BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Mar. 2002, Peer-reviewed

      Misc.

      • 細胞周期中のCCANの構成の動的な変化(Dynamic Change of CCAN organization during the cell cycle)
        Nagpal Harsh; 堀 哲也; Furukawa Ayako; 菅瀬 謙治; 越阪部 晃永; 胡桃坂 仁志; 深川 竜郎
        日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015
      • Deamination mechanism of an anti-HIV APOBEC3G coupled with sliding on single-stranded DNA as analyzed by real-time NMR monitoring method
        Kanba, K; Furukawa, A; Sugase, K; Nagata, T; Katahira, M
        The 41st International Symposium on Nucleic Acids Chemistry, Nov. 2014
      • Real-time NMR monitoring of enzymatic reaction of anti-HIV protein, structure of anti-prion RNA aptamer and wood biomass analysis
        Kanba, K; Mashima, T; Okamura, H; Furukawa, A; Sugase, K; Nishimura, H; Watanabe, T; Nagata, T; Katahira, M
        The 5th Japan-Taiwan NMR symposium, Sep. 2014, Peer-reviewed
      • Functional mechanism of an anti-HIV protein, APOBEC3G, as revealed by real-time NMR monitoring of its enzymatic reaction
        Kanba, K; Furukawa, A; Sugase, K; Morishita, R; Nagata, T; Katahira, M
        XXVIth International Conference on Magnetic Resonance in Biological Systems, Aug. 2014
      • Functional mechanism of anti-HIV protein, APOBEC3G, elucidated by real-time monitoring of enzymatic reaction, and anti-prion activity of an RNA aptamer with its structural basis
        K. Kanba; A. Furukawa; K. Sugase; R. Morishita; T. Nagata; M. Katahira
        The 45th Annual Meeting of Korean Magnetic Resonance Society, Jul. 2014, Invited
      • The deamination of APOBEC3G os controlled by the sliding-direction-dependent catalytic activity, and anti-prion activity of an RNA aptamer and its structural basis
        Furukawa, A; Sugase, K; Morishita, R; Nagata, T; Takaori-Kondo, A; Ryo, A; Mashima, T; Nishikawa, F; Nishikawa, S; Kamatari, Y; Kuwata, K; Katahira, M
        The 10th Korea-Japan Bilateral Symposium, 2013, Invited
      • 抗HIV宿主因子 APOBEC3Gの位置依存的デアミネーション反応機構の解明
        Furukawa, A; Sugase, K; Morishita, R; Nagata, T; Ryo, A; Takaori, A; Katahira, M
        日本生物物理学会第50回年会.名古屋, Sep. 2012
      • Elucidation of the location-dependent deamination reaction mechanism of an anti-HIV factor, APOBEC3G
        FURUKAWA Ayako; SUGASE Kenji; MORISHITA Ryo; NAGATA Taashi; TAKAORI Akifumi; RYO Akihide; KATAHIRA Masato
        生物物理, 15 Aug. 2012
      • Sliding-direction-dependent activity of anti-HIV enzyme,and structural basis of anti-prion activity of RNA aptamer
        Furukawa, A; Mashima, T; Sugase, K; Fujiwara, H; Nagata, T; Morishita, R; Ryo, A; Nishikawa, F; Nishikawa, S; Kamatari, KO; Kuwata, K; Katahira, M
        Korea-Japan Bilateral NMR Symposium, 16 Mar. 2012
      • The base-deamination rate dependent on the direction of sliding of an enzyme along DNA as revealed by numerical analysis of NMR data, and wood biomass studied by solution NMR
        Nishimura, H; Furukawa, A; Okamura, H; Kozawa, Y; Morishita, R; Ryo, A; Sugase, K; Watanabe, T; Katahira, M
        The International Symposium on Nuclear Magnetic Resonance 2011, Nov. 2011
      • NMR study of XMRV protease in complex with an inhibitor
        Okamura, H; Matsunaga, T; Furukawa, A; Sato, Y; Iwaoka, R; Nagata, T; Kobayashi, N; Takaori, A; Morishita, R; Ryo, A; Katahira, M
        第49回日本生物物理学会年会.姫路, Sep. 2011
      • リアルタイムモニタリングによって示されたAPBEC3GによるDNA上の極性を有したスライディングとカップルしたシトシン脱アミノ基反応
        Katahira, M; Furukawa, A; Nagata, T; Takaku, H; Morishita, R; Takaori, A; Ryo, A
        第49回日本生物物理学会年会.姫路, Sep. 2011
      • MagRO-Assign: a tool for automated sequence specific assignment of chemical shifts for NMR signals of protein backbone
        Kobayashi, N; Furukawa, A; Kitazawa, R; Nagata, T; Kitahara, R; Katahira, M; Fujiwara, T
        EUROMAR2011. Frankfurt, 21 Aug. 2011
      • XMRVプロテアーゼのNMRによる構造解析
        古川亜矢子; 松永智子; 岩岡諒; 永田崇; 小林直弘; 高折晃史; 森下了; 梁明秀; 片平正人
        第11回日本蛋白質科学会年会.大阪, Jun. 2011
      • An in vitro cleavage assay system for XMRV protease by wheat-germ cell free protein production.
        Matsunaga Satoko; Sawasaki Tatsuya; Kojima Yoshitsugu; Morishita Ryo; Sato Hironori; Ode Hirotaka; Furukawa Ayako; Katahira Masato; Sugiura Wataru; Ryo Akihide
        Abstracts for Annual Meeting of Japanese Proteomics Society, 2011
      • 抗HIV活性をもつAPOBE3GとAPOBEC3Fの構造機能解析
        岩岡諒; 古川亜矢子; 高折晃史; 森下了; 梁明秀; 片平正人
        第33回日本分子生物学会年会, Dec. 2010, Peer-reviewed
      • 抗HIV活性をもつAPOBEC3GとAPOBEC3Fの構造機能解析
        岩岡諒; 古川亜矢子; 高折晃史; 森下了; 梁明秀; 片平正人
        生化学, Dec. 2010
      • RNAアプタマー:プリオンタンパク質部分ペプチド複合体の構造及びA3Gタンパク質のDNA上スライディングの解析
        古川亜矢子; 真嶋司; 岩岡諒; 越田高史; 永田崇; 森下了; 梁明秀; 高折晃史; 西川富美子; 西川諭; 片平正人
        第49回NMR討論会、東京, Dec. 2010
      • 抗HIV因子APOBE3Gによる酵素反応のリアルタイムモニタリング
        古川亜矢子; 永田崇; 森下了; 梁明秀; 高折晃史; 片平正人
        平成22年度 日本分光学会年次講演会, Nov. 2010, Peer-reviewed
      • 「NMRシグナルを用いた抗ウィルス因子活性のリアルタイムモニタリング
        古川亜矢子; 永田崇; 森下了; 高折晃史; 梁明秀; 片平正人
        第58回日本ウィルス学会学術集会.徳島, Nov. 2010
      • APOBEC3Gが抗HIV活性を発揮する酵素反応のリアルタイムモニタリング
        古川 亜矢子; 永田 崇; 森下 了; 梁 昭秀; 高折 晃史; 片平 正人
        平成22年度日本分光学会.京都, Nov. 2010
      • The real-time monitoringof the enzymatic reaction of an anti-HIV factor APOBEC3G
        Furukawa, A; Nagata,T; Morishita, R; Iwaoka, R; Katahira, M
        XXIV International Conference on Magnetic Resonance in Biological Systems, Cairns, 22 Aug. 2010
      • Heat shock protein 70 inhibits HIV-1 Vif-mediated ubiquitination and degradation of Apobec3G
        Ryuichi Sugiyama; Hironori Nishitsuji; Yuichiro Habu; Haruki Naganuma; Hiroshi Koseki; Ayako Furukawa; Takashi Nagata; Masato Katahira; Hiroshi Takaku
        EUROPEAN JOURNAL OF MEDICAL RESEARCH, Aug. 2010
      • Real-time monitoring of the enzymatic reaction of APOBEC3G possessing anti-HIV activity, and the structure of the RNA aptamer against prion protein
        Furukawa, A; Mashima, T; Matsugami, A; Nagata. T; Sugiyama, R; Takaku, H; Nishikawa, F; Nishikawa, S; Katahira, M
        International Symposium of Korean Society of Biochemistry and Molecular Biology -Structural Biology and Drug Discovery, Aug. 2010
      • HIV遺伝子上でのAPOBEC3Gによるシチジンデアミネーション反応の動作機序
        古川亜矢子; 永田崇; 森下了; 杉山隆一; 高久洋; 高折晃史; 梁明秀; 片平正人
        第10回日本蛋白質科学会年会.北海道, Jun. 2010
      • The analysis of the mechanism of an enzyme reaction toward the development of new energy systems
        Iwaoka, R; Furukawa, A; Katahira, M
        The 2nd International Symposium of Kyoto University Global COE Program –Zero Carbon Energy Kyoto 2010-,, 2010
      • 抗HIV活性を有する天然型APOBEC3Gタンパク質の構造、1本鎖DNAとの相互作用及び酵素反応のリアルタイムモニタリング
        古川 亜矢子; 永田 崇; 杉山 隆一; 高久 洋; 片平 正人
        第32回分子生物学会年会.横浜, Dec. 2009
      • 抗HIV活性を保持するタンパク質APOBEC3Gの酵素反応のリアルタイムモニタリング
        古川 亜矢子; 中居 佑介; 永田 崇; 杉山 隆一; 高久 洋; 片平 正人
        第32回分子生物学会年会.横浜, Dec. 2009
      • 酵素反応のリアルタイムモニタリングとアプタマーによるプリオンタンパク質の捕捉機構
        古川亜矢子; 真嶋司; 永田崇; 杉山隆一; 高久洋; 西川富美子; 西川諭; 片平正人
        第48回NMR討論会.九州大学, Nov. 2009
      • Anti-HIV-1 Activity of A3G is Enhanced by HSP70
        Ryuichi Sugiyama; Yuichiro Habu; Haruki Naganuma; Hiroshi Koseki; Ayako Furukawa; Takashi Nagata; Masato Katahira; Hiroshi Takaku
        ANTIVIRAL RESEARCH, May 2009
      • HIVの複製を阻害するタンパク質APOBEC3Gの構造、相互作用及び酵素反応のリアルタイムモニタリング
        古川 亜矢子; 永田 崇; 羽生 勇一郎; 杉山 隆一; 林 文晶; 横山 茂之; 高久 洋; 片平 正人
        第9回日本蛋白質科学会年会.熊本, May 2009
      • HIVの複製を阻害するタンパク質APOBEC3Gの構造と相互作用の解析
        古川 亜矢子; 永田 崇; 羽生 勇一郎; 杉山 隆一; 林 文晶; 横山 茂之; 高久 洋; 片平 正人
        第31回日本分子生物学会年会・第82回日本生化学会大会.神戸, Dec. 2008
      • RDC、PRE及びPCSに基づいたMusashi-RNA複合体とプリオンタンパク質に対するRNAアプタマーの構造とダイナミクス
        大山貴子; 松上明正; 古川亜矢子; 真嶋司; 杉山孝司; 今井貴雄; 岡野栄之; 西川富美子; 西川諭; 山崎俊夫; 永田崇; 片平正人
        第47回NMR討論会.筑波大学, Nov. 2008
      • Hsp70のHIV-1感染抑制
        杉山 隆一; 羽生 勇一郎; 長沼 晴樹; 小関 寛; 永田 崇; 古川 亜矢子; 片平 正人; 高久 洋
        第56回ウィルス学会.岡山, Oct. 2008
      • Structures and interactions of 4’-thioDNA and RNA/DNA-binding proteins
        Ohyama, T; Matsugami, A; Furukawa, A; Mashima, T; Sugiyama, T; Yamazaki, T; Nagata, T; Katahira, M
        23rd International Conference of Magnetic Resonance in Biological Systems. San Diego, 24 Aug. 2008
      • Structural analysis of Musashi-RNA complex with paramagnetic effects
        Ohyama, T; Nagata, T; Furukawa, A; Sugiyama, T; Mashima, T; Yamazaki, T; Katahira, M
        XXIII International Conference on Magnetic Resonance in Biological Systems.San Diego,2008.8.24-29, Aug. 2008
      • HIV感染の防御に関与するAPOBEC3Gの構造機能解析
        古川亜矢子; 水内祐基; 河合文隆; 羽生勇一郎; 杉山隆一; 高久洋; 永田崇; 片平正人
        第30回日本分子生物学会年会・第80回日本生化学会大会.横浜, Jul. 2008
      • ロングレンジの構造情報を利用したMusashiタンパク質と標的RNAとの複合体の構造解析
        大山貴子; 大柄晶太; 宮ノ入洋平; 古川亜矢子; 今井貴雄; 岡野栄之; 永田崇; 片平正人
        第30回日本分子生物学会年会・第80回日本生化学会大会.横浜, Jul. 2008
      • ロングレンジの距離情報の抽出に基づいたマルチドメインタンパク質Musashiと標的RNAの複合体の構造解析
        大山貴子; 永田崇; 古川亜矢子; 杉山孝司; 真嶋司; 今井貴雄; 岡野栄之; 山崎俊夫; 片平正人
        RNA meeting 2008.札幌, Jul. 2008
      • エピジェネティクス実験スタンダード〜もう悩まない! ゲノム機能制御の読み解き方 (実験医学別冊)
        牛島 俊和; 眞貝 洋一; 塩見 春彦
        羊土社, 22 May 2017, Not refereed

      Industrial Property Rights

      • 特開2010-248179, 特願2010-067254, 医薬組成物
        高久 洋; 杉山 隆一; 片平 正人; 永田 崇; 古川 亜矢子

      Awards

      • 27 Aug. 2021
        進歩賞(日本核磁気共鳴学会)
      • 17 Nov. 2010
        若手ポスター賞(日本核磁気共鳴学会)

      External funds: Kakenhi

      • Elucidation of dynamic interactions between histone tails and DNA in chromatosome.
        Grant-in-Aid for Transformative Research Areas (A)
        Transformative Research Areas, Section (III)
        Kyoto University
        古川 亜矢子
        From 01 Apr. 2023, To 31 Mar. 2025, Granted
        ヌクレオソーム;溶液NMR;ヒストンテイル;動的な相互作用;NMR
      • 液液相分離したリン酸化HP1αのヌクレオソーム結合への機能解明
        Grant-in-Aid for Scientific Research (C)
        Basic Section 43040:Biophysics-related
        Yokohama City University
        古川 亜矢子
        From 01 Apr. 2021, To 31 Mar. 2024, Granted
        HP1α;溶液NMR;液液相分離;ヘテロクロマチンタンパク質HP1α;動的構造解析
      • Elucidation of dynamic interactions of histone tails with nucleosomal DNA or linker DNA
        Grant-in-Aid for Transformative Research Areas (A)
        Transformative Research Areas, Section (III)
        Yokohama City University
        古川 亜矢子
        From 10 Sep. 2021, To 31 Mar. 2023, Project Closed
        ヌクレオソーム;溶液NMR;ヒストンテイル;動的な相互作用;ヒストン
      • インプリント遺伝子のDNAメチル化模様を制御するDnmt3aの過渡的複合体
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Complex systems
        Yokohama City University
        古川 亜矢子
        From 01 Apr. 2015, To 31 Mar. 2018, Project Closed
        DNAメチル化;リアルタイムNMR;酵素反応;DNAのメチル化
      • Regulation of heme oxygenase-2 activity elucidated by the analysis of structural dynamics
        Grant-in-Aid for Young Scientists (B)
        Yokohama City University;Suntory Foundation for Life Sciences
        Ayako Furukawa
        From 01 Apr. 2014, To 31 Mar. 2017, Project Closed
        動的構造解析;酵素;タンパク質の動的構造解析;酵素の調節機構;蛋白質の動的構造解析
      • HIV感染阻害宿主因子APOBEC3Gを生かした新規抗HIV薬の開発基盤の確立
        Grant-in-Aid for Young Scientists (B)
        Yokohama City University
        古川 亜矢子
        From 01 Apr. 2010, To 31 Mar. 2011, Project Closed
      list
        Last Updated :2024/12/03

        Education

        Teaching subject(s)

        • From 01 Apr. 2024, To 31 Mar. 2025
          Applied Life Sciences III
          CA03, Spring, Graduate School of Agriculture, 1
        • From 01 Apr. 2024, To 31 Mar. 2025
          Biomacromolecular Chemistry
          CA21, Spring, Graduate School of Agriculture, 1
        • From 01 Apr. 2024, To 31 Mar. 2025
          Macromolecular Bioscience Seminar
          CF02, Fall, Graduate School of Agriculture, 1.5
        • From 01 Apr. 2024, To 31 Mar. 2025
          Macromolecular Bioscience Seminar
          CF02, Spring, Graduate School of Agriculture, 1.5
        • From 01 Apr. 2024, To 31 Mar. 2025
          Experimental Course of Macromolecular Bioscience
          CG02, Spring, Graduate School of Agriculture, 3
        • From 01 Apr. 2024, To 31 Mar. 2025
          Experimental Course of Macromolecular Bioscience
          CG02, Fall, Graduate School of Agriculture, 3
        • From 01 Apr. 2024, To 31 Mar. 2025
          Laboratory Course in Biochemistry
          5669, Spring, Faculty of Agriculture, 3
        • From 01 Apr. 2024, To 31 Mar. 2025
          General Biomacromolecular Chemistry
          5633, Spring, Faculty of Agriculture, 2
        • From 01 Apr. 2024, To 31 Mar. 2025
          Structure and Function of Biomacromolecules
          5635, Fall, Faculty of Agriculture, 2

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