Basic Information

Affiliated programs (koza)

• Graduate School of Medicine, 医学専攻　病因免疫学
• Graduate School of Medicine, 医科学専攻　病因免疫学, 教授
• Graduate School of Pharmaceutical Sciences, 生体分子薬学, 教授

Email Address

• Email Address

  ito.yoshinaga.6ekyoto-u.ac.jp

Professional Memberships

• American Association for Cancer Research
• 日本リウマチ学会
• 日本免疫学会

Academic Degree

• 24 Sep. 2009

  京都大学博士（医学）

Academic Resume (Graduate Schools)

• 京都大学, 大学院医学研究科博士課程医学専攻, 修了
• 京都大学, 大学院医学研究科博士課程医学専攻, 研究指導認定退学

Academic Resume (Undergraduate School/Majors)

• 京都大学, 医学部医学科, 卒業

Research History

• From Apr. 2022, To Present

  京都大学医生物学研究所, 再生組織構築研究部門病因免疫学分野, 教授
• From May 2020, To Mar. 2022

  Harvard Medical School, Department of Immunology,, Instructor
• From Apr. 2015, To Apr. 2020

  Harvard Medical School, Department of Immunology, Research Fellow
• From Apr. 2011, To Mar. 2015

  京都大学再生医科学研究所, 生体機能調節学分野, 助教
• From Apr. 2009, To Mar. 2011

  京都大学再生医科学研究所, 生体機能調節学分野, 研究員
• From Apr. 2004, To Mar. 2005

  京都市立病院, 専攻医
• From Jun. 2003, To Mar. 2004

  京都市立病院, 内科研修医
• From Apr. 2002, To Jun. 2003

  京都大学医学部附属病院, 内科研修医

ID,URL

• J-Global ID

  201401052374003036

• External link

  https://ito-lab-en.labby.jp/

researchmap URL

• https://researchmap.jp/Yoshinaga_Ito

Research

Research Areas

• Life sciences, Tumor diagnostics and therapeutics, 腫瘍免疫学
• Life sciences, Allergies and connective tissue disease
• Life sciences, Immunology

Papers

• Defective removal of invariant chain peptides from MHC class II suppresses tumor antigen presentation and promotes tumor growth.

  Joanna Bandola-Simon; Yoshinaga Ito; Kai W Wucherpfennig; Paul A Roche

  Cell reports, 02 Jan. 2025

  
• Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell-Secreted Cytokines.

  Yoshinaga Ito; Deng Pan; Wubing Zhang; Xixi Zhang; Tiffany Y Juan; Jason W Pyrdol; Oleksandr Kyrysyuk; John G Doench; X Shirley Liu; Kai W Wucherpfennig

  Cancer discovery, 04 May 2023, Lead author, Corresponding author

  
• Construction of a T cell receptor signaling range for spontaneous development of autoimmune disease.

  Atsushi Tanaka; Shinji Maeda; Takashi Nomura; Mara Anais Llamas-Covarrubias; Satoshi Tanaka; Lin Jin; Ee Lyn Lim; Hiromasa Morikawa; Yohko Kitagawa; Shuji Akizuki; Yoshinaga Ito; Chihiro Fujimori; Keiji Hirota; Tosei Murase; Motomu Hashimoto; Junichi Higo; Rose Zamoyska; Ryuzo Ueda; Daron M Standley; Noriko Sakaguchi; Shimon Sakaguchi

  The Journal of experimental medicine, 06 Feb. 2023

  
• CARM1 Inhibition Enables Immunotherapy of Resistant Tumors by Dual Action on Tumor Cells and T Cells.

  Sushil Kumar; Zexian Zeng; Archis Bagati; Rong En Tay; Lionel A Sanz; Stella R Hartono; Yoshinaga Ito; Fieda Abderazzaq; Elodie Hatchi; Peng Jiang; Adam N R Cartwright; Olamide Olawoyin; Nathan D Mathewson; Jason W Pyrdol; Mamie Z Li; John G Doench; Matthew A Booker; Michael Y Tolstorukov; Stephen J Elledge; Frédéric Chédin; X Shirley Liu; Kai W Wucherpfennig

  Cancer discovery, Aug. 2021, Peer-reviewed

  
• Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis.

  Nathan D Mathewson; Orr Ashenberg; Itay Tirosh; Simon Gritsch; Elizabeth M Perez; Sascha Marx; Livnat Jerby-Arnon; Rony Chanoch-Myers; Toshiro Hara; Alyssa R Richman; Yoshinaga Ito; Jason Pyrdol; Mirco Friedrich; Kathrin Schumann; Michael J Poitras; Prafulla C Gokhale; L Nicolas Gonzalez Castro; Marni E Shore; Christine M Hebert; Brian Shaw; Heather L Cahill; Matthew Drummond; Wubing Zhang; Olamide Olawoyin; Hiroaki Wakimoto; Orit Rozenblatt-Rosen; Priscilla K Brastianos; X Shirley Liu; Pamela S Jones; Daniel P Cahill; Matthew P Frosch; David N Louis; Gordon J Freeman; Keith L Ligon; Alexander Marson; E Antonio Chiocca; David A Reardon; Aviv Regev; Mario L Suvà; Kai W Wucherpfennig

  Cell, 04 Mar. 2021, Peer-reviewed

  
• Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells.

  Rong En Tay; Olamide Olawoyin; Paloma Cejas; Yingtian Xie; Clifford A Meyer; Yoshinaga Ito; Qing Yu Weng; David E Fisher; Henry W Long; Myles Brown; Hye-Jung Kim; Kai W Wucherpfennig

  The Journal of experimental medicine, 06 Jul. 2020, Peer-reviewed

  
• Correction: Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells.

  Rong En Tay; Olamide Olawoyin; Paloma Cejas; Yingtian Xie; Clifford A Meyer; Yoshinaga Ito; Qing Yu Weng; David E Fisher; Henry W Long; Myles Brown; Hye-Jung Kim; Kai W Wucherpfennig

  The Journal of experimental medicine, 06 Jul. 2020

  
• Inhibition of MICA and MICB Shedding Elicits NK-Cell-Mediated Immunity against Tumors Resistant to Cytotoxic T Cells.

  Lucas Ferrari de Andrade; Sushil Kumar; Adrienne M Luoma; Yoshinaga Ito; Pedro Henrique Alves da Silva; Deng Pan; Jason W Pyrdol; Charles H Yoon; Kai W Wucherpfennig

  Cancer immunology research, Jun. 2020, Peer-reviewed

  
• Discovery of specialized NK cell populations infiltrating human melanoma metastases.

  Lucas Ferrari de Andrade; Yuheng Lu; Adrienne Luoma; Yoshinaga Ito; Deng Pan; Jason W Pyrdol; Charles H Yoon; Guo-Cheng Yuan; Kai W Wucherpfennig

  JCI insight, 05 Dec. 2019, Peer-reviewed

  
• Strain-Specific Manifestation of Lupus-like Systemic Autoimmunity Caused by Zap70 Mutation.

  Matsuo T; Hashimoto M; Sakaguchi S; Sakaguchi N; Ito Y; Hikida M; Tsuruyama T; Sakai K; Yokoi H; Shirakashi M; Tanaka M; Ito H; Yoshifuji H; Ohmura K; Fujii T; Mimori T

  Journal of immunology (Baltimore, Md. : 1950), Jun. 2019, Peer-reviewed

  
• Rapid CLIP dissociation from MHC II promotes an unusual antigen presentation pathway in autoimmunity.

  Yoshinaga Ito; Orr Ashenberg; Jason Pyrdol; Adrienne M Luoma; Orit Rozenblatt-Rosen; Matan Hofree; Elena Christian; Lucas Ferrari de Andrade; Rong En Tay; Luc Teyton; Aviv Regev; Stephanie K Dougan; Kai W Wucherpfennig

  The Journal of experimental medicine, 01 Oct. 2018, Peer-reviewed, Lead author

  
• Autoimmune Th17 Cells Induced Synovial Stromal and Innate Lymphoid Cell Secretion of the Cytokine GM-CSF to Initiate and Augment Autoimmune Arthritis.

  Hirota K; Hashimoto M; Ito Y; Matsuura M; Ito H; Tanaka M; Watanabe H; Kondoh G; Tanaka A; Yasuda K; Kopf M; Potocnik AJ; Stockinger B; Sakaguchi N; Sakaguchi S

  Immunity, Jun. 2018, Peer-reviewed

  
• Antibody-mediated inhibition of MICA and MICB shedding promotes NK cell-driven tumor immunity.

  Lucas Ferrari de Andrade; Rong En Tay; Deng Pan; Adrienne M Luoma; Yoshinaga Ito; Soumya Badrinath; Daphne Tsoucas; Bettina Franz; Kenneth F May Jr; Christopher J Harvey; Sebastian Kobold; Jason W Pyrdol; Charles Yoon; Guo-Cheng Yuan; F Stephen Hodi; Glenn Dranoff; Kai W Wucherpfennig

  Science (New York, N.Y.), 30 Mar. 2018, Peer-reviewed

  
• Cell-contact-dependent activation of CD4⁺ T cells by adhesion molecules on synovial fibroblasts.

  Mori M; Hashimoto M; Matsuo T; Fujii T; Furu M; Ito H; Yoshitomi H; Hirose J; Ito Y; Akizuki S; Nakashima R; Imura Y; Yukawa N; Yoshifuji H; Ohmura K; Mimori T

  Modern rheumatology, May 2017, Peer-reviewed

  
• Dysbiosis Contributes to Arthritis Development via Activation of Autoreactive T Cells in the Intestine.

  Yuichi Maeda; Takashi Kurakawa; Eiji Umemoto; Daisuke Motooka; Yoshinaga Ito; Kazuyoshi Gotoh; Keiji Hirota; Masato Matsushita; Yoki Furuta; Masashi Narazaki; Noriko Sakaguchi; Hisako Kayama; Shota Nakamura; Tetsuya Iida; Yukihiko Saeki; Atsushi Kumanogoh; Shimon Sakaguchi; Kiyoshi Takeda

  Arthritis & rheumatology (Hoboken, N.J.), Nov. 2016, Peer-reviewed

  
• P1-06 TCR signalの異常とループス

  松尾 崇史; 橋本 求; 疋田 正喜; 坂井 薫; 横井 秀基; 伊藤 能永; 森 将人; 藤井 隆夫; 坂口 志文; 三森 経世

  日本臨床免疫学会会誌, 2016

  
• Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease.

  Ito Y; Hashimoto M; Hirota K; Ohkura N; Morikawa H; Nishikawa H; Tanaka A; Furu M; Ito H; Fujii T; Nomura T; Yamazaki S; Morita A; Vignali DA; Kappler JW; Matsuda S; Mimori T; Sakaguchi N; Sakaguchi S

  Science (New York, N.Y.), Oct. 2014, Peer-reviewed, Lead author

  
• TREG-cell therapies for autoimmune rheumatic diseases.

  Makoto Miyara; Yoshinaga Ito; Shimon Sakaguchi

  Nature reviews. Rheumatology, Sep. 2014

  
• 関節リウマチの活動性とリウマトイド因子、免疫グロブリン値は相関するのか?

  片山 昌紀; 村上 孝作; 伊藤 博崇; 船越 莊兵; 伊藤 能永; 井村 嘉孝

  日本リウマチ学会総会・学術集会プログラム・抄録集, Mar. 2014

  
• リウマトイド因子陽性関節リウマチの治療とリウマトイド因子の変化

  片山 昌紀; 村上 孝作; 伊藤 博崇; 船越 莊平; 伊藤 能永; 井村 嘉孝

  日本内科学会雑誌, Feb. 2014

  
• 感染症と自己免疫疾患 B型肝炎ウイルスの既往感染を有する関節リウマチの臨床的検討

  村上 孝作; 日和 良介; 中島 俊樹; 伊藤 能永; 井村 嘉孝

  日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, Mar. 2013

  
• T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

  Naganari Ohkura; Masahide Hamaguchi; Hiromasa Morikawa; Kyoko Sugimura; Atsushi Tanaka; Yoshinaga Ito; Motonao Osaki; Yoshiaki Tanaka; Riu Yamashita; Naoko Nakano; Jochen Huehn; Hans Joerg Fehling; Tim Sparwasser; Kenta Nakai; Shimon Sakaguchi

  IMMUNITY, Nov. 2012, Peer-reviewed

  
• Thymus, innate immunity and autoimmune arthritis: Interplay of gene and environment

  Shimon Sakaguchi; Satoshi Tanaka; Atsushi Tanaka; Yoshinaga Ito; Shinji Maeda; Noriko Sakaguchi; Motomu Hashimoto

  FEBS LETTERS, Dec. 2011, Peer-reviewed

  
• Overexpression of a Minimal Domain of Calpastatin Suppresses IL-6 Production and Th17 Development via Reduced NF-kappa B and Increased STAT5 Signals

  Mikiko Iguchi-Hashimoto; Takashi Usui; Hajime Yoshifuji; Masakazu Shimizu; Shio Kobayashi; Yoshinaga Ito; Kosaku Murakami; Aoi Shiomi; Naoichiro Yukawa; Daisuke Kawabata; Takaki Nojima; Koichiro Ohmura; Takao Fujii; Tsuneyo Mimori

  PLOS ONE, Oct. 2011, Peer-reviewed

  
• Graded Attenuation of TCR Signaling Elicits Distinct Autoimmune Diseases by Altering Thymic T Cell Selection and Regulatory T Cell Function

  Satoshi Tanaka; Shinji Maeda; Motomu Hashimoto; Chihiro Fujimori; Yoshinaga Ito; Shin Teradaira; Keiji Hirota; Hiroyuki Yoshitomi; Tomoya Katakai; Akira Shimizu; Takashi Nomura; Noriko Sakaguchi; Shimon Sakaguchi

  JOURNAL OF IMMUNOLOGY, Aug. 2010, Peer-reviewed

  
• Gamma/Delta T Cells Are the Predominant Source of Interleukin-17 in Affected Joints in Collagen-Induced Arthritis, but Not in Rheumatoid Arthritis

  Yoshinaga Ito; Takashi Usui; Shio Kobayashi; Mikiko Iguchi-Hashimotol; Hiromu Ito; Hiroyuki Yoshitomi; Takashi Nakamura; Masakazu Shimizu; Daisuke Kawabata; Naoichiro Yukawa; Motomu Hashimoto; Noriko Sakaguch; Shimon Sakaguchi; Hajime Yoshifuji; Takaki Nojima; Koichiro Ohmura; Takao Fujii; Tsuneyo Mimori

  ARTHRITIS AND RHEUMATISM, Aug. 2009, Peer-reviewed, Lead author

  
• Severe subcutaneous generalized edema in a patient with dermatomyositis

  Yoshinaga Ito; Daisuke Kawabata; Naoichiro Yukawa; Hajime Yoshifuji; Takashi Usui; Masao Tanaka; Takao Fujii; Tsuneyo Mimori

  Modern Rheumatology, Apr. 2007, Peer-reviewed, Lead author

  

Misc.

• 免疫学 免疫療法抵抗性がんの新しい治療標的の解明─がん細胞をT細胞サイトカインに感受性化する

  伊藤能永

  医学のあゆみ, Apr. 2024

  
• Inflammatory circuit of Th17 cells, fibroblast-like synoviocytes, and ILCs in the development of autoimmune arthritis

  K. Hirota; Y. Ito; M. Hashimoto; H. Watanabe; G. Kondoh; A. Tanaka; K. Yasuda; M. Kopf; A. J. Potocnik; B. Stockinger; N. Sakaguchi; S. Sakaguchi

  EUROPEAN JOURNAL OF IMMUNOLOGY, Aug. 2016

  
• 60S ribosomal protein L23a (RPL23A) is a target self-antigen of arthritogenic T cells

  伊藤 能永; 坂口 志文

  臨床免疫・アレルギー科, Apr. 2015

  
• 自己免疫疾患における全身に発現するタンパク質に対するT細胞性の免疫応答の検出

  伊藤能永; 坂口志文

  ライフサイエンス新着論文レビュー, Oct. 2014

  
• リウマチ性疾患の基礎研究 滑膜線維芽細胞との細胞接触がCD4+T細胞のサイトカイン産生に与える影響

  森 将人; 橋本 求; 松尾 崇史; 布留 守敏; 伊藤 宣; 藤井 隆夫; 吉富 啓之; 伊藤 能永; 秋月 修治; 中嶋 蘭; 井村 嘉孝; 湯川 尚一郎; 吉藤 元; 大村 浩一郎; 三森 経世

  日本リウマチ学会総会・学術集会プログラム・抄録集, Mar. 2014

  
• Epigenetic conversion and \nFoxp3 expression are complimentary events required for regulatory T cell development

  OHKURA Naganari; HAMAGUCHI Masahide; MORIKAWA Hiromasa; SUGIMURA Kyoko; TANAKA Atsushi; ITO Yoshinaga; OSAKI Motonao; NAKANO Naoko; SAKAGUCHI Shimon

  第41 回日本免疫学 会学術集会（2012.12.5－7．神戸）, 2012, Peer-reviewed

  
• The contribution and cellular source of GM-CSF in a murine model of autoimmunity

  Nicholas Edward Crabb; Motomu Hashimoto; Yoshinaga Ito; Tosei Murase; Atushi Tanaka; Shimon Sakaguchi

  Kyoto T Cell Conference 第22 回学術集会（2012.7.6－7．京都）, 2012, Peer-reviewed

  
• Concurrent epigenetic conversion and Foxp3 expression have \ncomplementary roles in the development of regulatory T cells

  Masahide Hamaguchi; Naganari Ohkura; Hiromasa Morikawa; Kyoko Sugimura; Atsushi Tanaka; Yoshinaga Ito; Motonao Osaki; Yoshiaki Tanaka; Riu Yamashita; Naoko Nakano; Jochen Huehn; Tim Sparwasser; Kenta Nakai; Shimon Sakaguchi

  Joint Symposium of Seoul St. Mary’s Hop, Osaka Univ. Postech.（2011. 12. 19. Seoul, Korea）, 19 Dec. 2011, Peer-reviewed

  
• Autoimmune arthritis caused by altered thymic T-cell selection due to a mutation of the ZAP-70 gene.

  Ito Y; Sakaguchi S

  1st Bio-Rheumatology International Congress/8th GARN Meeting Tokyo, 2012

  
• Autoimmune Diseases, RA: Genetics

  Yoshinaga Ito, Shimon Sakaguchi

  Encyclopedia of Medical Immunology, 2010

  
• 自己免疫疾患の免疫応答

  伊藤能永; 坂口志文

  最新医学 68巻3月増刊号 自己免疫疾患・アレルギー疾患, 2010

  
• CD25+CD4+制御性T細胞と自己免疫病

  野村尚志; 伊藤能永; 坂口志文

  EXPERT膠原病・リウマチ 改訂第３版, 2010

  
• 全身性自己免疫疾患 モデル解析 正常ZAP-70の発現量操作による自己免疫性関節炎の誘導

  前田 伸治; 田中 聡; 廣田 圭司; 藤森 千尋; 野村 尚史; 秋月 修治; 橋本 求; 伊藤 能永; 坂口 教子; 坂口 志文

  日本免疫学会総会・学術集会記録, Nov. 2009, Peer-reviewed

  
• リウマチ性疾患の検査 血清IL-17F値は関節リウマチの新規バイオマーカーである

  小林 志緒; 臼井 崇; 伊藤 能永; 橋本 美季子; 吉藤 元; 清水 正和; 湯川 尚一郎; 川端 大介; 野島 崇樹; 大村 浩一郎; 藤井 隆夫; 三森 経世

  日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, Mar. 2009

  
• gdT細胞によるIL-17の産生とその意義

  伊藤能永; 三森経世

  臨床免疫・アレルギー科, 52(6):664-668,2009, 2009

  
• TCRシグナル不全による制御性T 細胞異常と自己免疫病の発症

  秋月修治; 坂口教子; 藤森千尋; 前田伸治; 伊藤能永; 橋本求; 野村尚史; 斎藤隆; 三森経世; 坂口志文

  第39回日本免疫学会総会学術集会（2009.12.2－4大阪）, 2009, Peer-reviewed

  
• RAの新たなる治療ターゲット―生物学的製剤を超えて―

  伊藤能永 三森経世

  Rheumatology Clinical Update, p48-49, Number15, September, 2008, Sep. 2008

  
• II型コラーゲン誘発性関節炎(CIA)局所におけるIL-17分泌細胞の解析

  伊藤 能永; 臼井 崇; 橋本 美季子; 小林 志緒; 吉藤 元; 三森 経世

  日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, Apr. 2008

  
• 関節リウマチの新たなる治療ターゲット 生物学的製剤を超えて 疾患特異的な免疫制御法の開発の可能性

  臼井 崇; 小林 志緒; 橋本 美季子; 伊藤 能永; 吉藤 元; 池田 高治; 湯川 尚一郎; 野島 崇樹; 大村 浩一郎; 藤井 隆夫; 三森 経世

  日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, Apr. 2007

  
• TNF阻害療法中にSLE様免疫異常を認めた関節リウマチの5例

  湯川 尚一郎; 藤井 隆夫; 中嶋 蘭; 伊藤 能永; 池田 高治; 吉藤 元; 野島 崇樹; 大村 浩一郎; 臼井 崇; 三森 経世

  日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, Apr. 2007

  
• Antigen specific immunotherapy using TGF-Beta expressing retrovirus and type II collagen specific CD4(+) T cells in type II collagen induced arthritis.

  Shio Kobayashi; Takashi Usui; Mikiko Hashimoto; Hajime Yoshifuji; Yoshinaga Ito; Koichiro Omura; Takao Fujii; Tsuneyo Mimori

  ARTHRITIS AND RHEUMATISM, Sep. 2006

  
• TNF阻害療法中にSLE様免疫異常を認めた関節リウマチの4例

  湯川 尚一郎; 藤井 隆夫; 中嶋 蘭; 伊藤 能永; 池田 高治; 吉藤 元; 野嶋 崇樹; 川端 大介; 大村 浩一郎; 臼井 崇; 三森 経世

  日本臨床免疫学会会誌, Aug. 2006

  
• Clinical significance of anti-SRP autoantibodies in polymyositis and dermatomyositis

  Y. Ito; H. Yoshifuji; S. Kobayashi; Y. Imura; T. Fujii; D. Kawabata; T. Usui; M. Tanaka; T. Mimori

  ANNALS OF THE RHEUMATIC DISEASES, Jul. 2006

  
• 多発性筋炎/皮膚筋炎の臨床 抗シグナル認識粒子(SRP)当体陽性多発性筋炎・皮膚筋炎(PM/DM)の臨床経過の解析

  伊藤 能永; 吉藤 元; 小林 志緒; 井村 嘉孝; 藤井 隆夫; 川端 大介; 臼井 崇; 田中 真生; 藤田 義正; 梅原 久範; 三森 経世

  日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, Mar. 2006

  
• 多発性筋炎/皮膚筋炎の病因・病態 カルパイン阻害によるマウス実験的筋炎の制御

  吉藤 元; 臼井 崇; 伊藤 能永; 橋本 美季子; 小林 志緒; 三森 経世

  日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, Mar. 2006

  
• びまん性肺胞出血(DAH)に対し二重膜濾過血漿交換療法(DFPP)が有効であったSLEの2症例

  中嶋 蘭; 川端 大介; 伊藤 能永; 野島 崇樹; 橋本 美季子; 井村 嘉孝; 吉藤 元; 田中 真生; 臼井 崇; 藤井 隆夫; 三森 経世

  日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, Mar. 2006

  
• 抗シグナル認識粒子(SRP)抗体陽性多発性筋炎・皮膚筋炎(PM/DM)の臨床経過の解析

  伊藤 能永; 吉藤 元; 小林 志緒; 井村 嘉孝; 藤井 隆夫; 川端 大介; 臼井 崇; 田中 真生; 藤田 義正; 梅原 久範; 三森 経世

  日本臨床免疫学会会誌, Aug. 2005

  

Presentations

• Immune responses to “self”

  伊藤能永

  第9回Clinical Immunology/Inflammation Seminar in Shinanomachi, 03 Feb. 2025, Invited

  
• Addressing Tumor;Heterogeneity by;Sensitizing Resistan;Cancer Cells to T cell-secreted Cytokines

  伊藤能永

  第52回日本臨床免疫学会, 10 Oct. 2024

  
• Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell-secreted Cytokines

  伊藤能永

  第33回Kyoto T Cell Conference, 15 Jun. 2024

  
• Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell-secreted Cytokines

  伊藤能永

  第52回日本免疫学会学術集会, 19 Jan. 2024

  
• Addressing Tumor Heterogeneity by Sensitizing Resistant Cancer Cells to T cell-secreted Cytokines

  伊藤能永

  第97回日本薬理学会年会シンポジウム, 14 Dec. 2023

  
• 自己免疫疾患惹起性T細胞の標的自己抗原の同定

  RA Biologic Conference in 広島, 09 Feb. 2015

  
• 自己免疫疾患惹起性T細胞の標的自己抗原の同定

  T-Cell Educational セミナー, 22 Jan. 2015

  
• T細胞はRPL23Aを標的自己抗原として関節炎を起こす

  第一回病因研究会別府シンポジウム, Jan. 2015

  
• Autoimmune arthritis caused by altered thymic T-cell selection due to a mutation of the ZAP-70 gene

  Yoshinaga Ito

  1st Bio-Rheumatology International Congress/8th GARN Meeting Tokyo, 14 Nov. 2011

  
• II型コラーゲン誘発性関節炎(CIA)局所におけるIL-17分泌細胞の解析

  伊藤 能永; 臼井 崇; 橋本 美季子; 小林 志緒; 吉藤 元; 三森 経世

  日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, Apr. 2008, (一社)日本リウマチ学会

  
• II型コラーゲン誘発性関節炎 (CIA)局所におけるIL-17分泌細胞の解析

  伊藤能永

  京都免疫ワークショップ, 2008

  
• II型コラーゲン誘発性関節炎局所におけるサイトカイン分泌細胞のプロファイル

  伊藤能永

  第４回 リウマチヤングアカデミー, 2008

  
• Clinical significance of anti-SRP autoantibodies in polymyositis and dermatomyositis

  Y. Ito; H. Yoshifuji; S. Kobayashi; Y. Imura; T. Fujii; D. Kawabata; T. Usui; M. Tanaka; T. Mimori

  ANNALS OF THE RHEUMATIC DISEASES, Jul. 2006, B M J PUBLISHING GROUP

  
• 多発性筋炎/皮膚筋炎の臨床 抗シグナル認識粒子(SRP)当体陽性多発性筋炎・皮膚筋炎(PM/DM)の臨床経過の解析

  伊藤 能永; 吉藤 元; 小林 志緒; 井村 嘉孝; 藤井 隆夫; 川端 大介; 臼井 崇; 田中 真生; 藤田 義正; 梅原 久範; 三森 経世

  日本リウマチ学会総会・学術集会・国際リウマチシンポジウムプログラム・抄録集, Mar. 2006, (一社)日本リウマチ学会

  
• 抗シグナル認識粒子(SRP)抗体陽性多発性筋炎・皮膚筋炎(PM/DM)の臨床経過の解析

  伊藤 能永; 吉藤 元; 小林 志緒; 井村 嘉孝; 藤井 隆夫; 川端 大介; 臼井 崇; 田中 真生; 藤田 義正; 梅原 久範; 三森 経世

  日本臨床免疫学会会誌, Aug. 2005, 日本臨床免疫学会

  

Awards

• 15 Apr. 2015

  日本リウマチ学会奨励賞

External funds: Kakenhi

• Identification of autoantigens recognized by pathogenic T cells in autoimmune arthritis

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Yoshinaga ITO

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  自己抗原;自己反応性T細胞;自己免疫性関節炎;疾患惹起性Ｔ細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790996/
• Molecular basis of the function and generation of Foxp3-expressing regulatory T cells

  Grant-in-Aid for Specially Promoted Research

  Biological Sciences

  Osaka University;Kyoto University

  Shimon SAKAGUCHI

  From 01 Apr. 2008, To 31 Mar. 2013, Project Closed

  FOXP3;制御性T細胞;自己免疫病;Tリンパ球;CTLA-4;免疫制御;制御性Ｔ細胞;エピゲノム;Ｔリンパ球;Ｔ細胞抗原レセプター;T細胞抗原レセプター

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20002007/
• 新規抵抗性経路の網羅的同定と解除による免疫治療抵抗性癌の克服と、分子機序の解明

  Grant-in-Aid for Research Activity Start-up

  0803:Pathology, infection/immunology, and related fields

  Kyoto University

  伊藤 能永

  From 31 Aug. 2022, To 31 Mar. 2024, Granted

  がん免疫療法;治療抵抗性がん;オートファジー;TNFシグナル経路;T細胞;癌免疫療法;治療抵抗性癌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K20758/
• GPIアンカー蛋白質を標的とした、抗原不均一免疫療法抵抗性がんの克服

  Grant-in-Aid for Scientific Research (B)

  Basic Section 49030:Experimental pathology-related

  Kyoto University

  伊藤 能永

  From 01 Apr. 2024, To 31 Mar. 2028, Granted

  免疫療法抵抗性がん

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02261/

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  ILAS Seminar

  Z001, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Pharmaceutical Biochemistry B

  8206, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Infection and Host Defense 1

  A216, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Infection and Host Defense II

  C217, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Infection and Host Defense I

  C216, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Infection and Host Defense 2

  A217, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Biochemistry

  8103, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Modern Life Sciences for Drug Discovery

  1027, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Molecular Genetics II

  3726, Spring, Faculty of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Infection and Host Defense II

  C217, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Infection and Host Defense I

  C216, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Infection and Host Defense 2

  A217, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Infection and Host Defense 1

  A216, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Modern Life Sciences for Drug Discovery

  1027, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Biochemistry

  8103, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2

Participation in PhD Defense

• Anti-integrin αvβ6 autoantibodies in patients with primary sclerosing cholangitis

  YOSHIDA HIROYUKI, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Chemical induction of splice-neoantigens attenuates tumor growth in a preclinical model of colorectal cancer

  MATSUSHIMA SHINGO, Graduate School of Medicine, Sub-chief Examiner

  25 Mar. 2024
• Positive and negative regulation of the Fcγ receptor-stimulatory activity of RNA-containing immune complexes by RNase

  NAITO RYOTA, Graduate School of Medicine, Sub-chief Examiner

  23 Jan. 2024
• Beta-1,4-galactosyltransferase-3 deficiency suppresses the growth of immunogenic tumors in mice

  WEI Heng, Graduate School of Medicine, Sub-chief Examiner

  23 Jan. 2024
• Identification of anti-citrullinated osteopontin antibodies and increased inflammatory response by enhancement of osteopontin binding to fibroblast-like synoviocytes in rheumatoid arthritis

  UMEMOTO AKIO, Graduate School of Medicine, Chief Examiner

  24 Jul. 2023
• Identification of T cell receptors targeting a neoantigen derived from recurrently mutated FGFR3

  TATE TOMOHIRO, Graduate School of Medicine, Sub-chief Examiner

  23 May 2023
• Oral dextran sulfate sodium administration induces peripheral spondyloarthritis features in SKG mice accompanied by intestinal bacterial translocation and systemic Th1 and Th17 cell activation

  TABUCHI YUYA, Graduate School of Medicine, Chief Examiner

  25 Mar. 2024
• PD-L1 on mast cells suppresses effector CD8+ T-cell activation in the skin in murine contact hypersensitivity

  HIRANO TOMOKO, Graduate School of Medicine, Sub-chief Examiner

  23 May 2023
• Increased number of T cells and exacerbated inflammatory pathophysiology in a human IgG4 knock-in MRL/lpr mouse model

  GON TAKAHO, Graduate School of Medicine, Chief Examiner

  23 Mar. 2023
• ABIN1 is a signal‐induced autophagy receptor that attenuates NF‐kB activation by recognizing linear ubiquitin chains

  SHINKAWA YUTAKA, Graduate School of Medicine, Sub-chief Examiner

  26 Sep. 2022
• LSD1 metabolically integrates osteoclast differentiation and inflammatory bone resorption through HIF-1α and E2F1

  DOI KOHEI, Graduate School of Medicine, Chief Examiner

  26 Sep. 2022

Part-time lecturer

• 感染防御学II／２

  京都大学, 薬学部

Administration

Faculty management (title, position)

• From 01 Oct. 2024

  医生物学研究所　将来構想委員会
• From 01 Apr. 2023

  薬学研究科　教務委員会
• From 01 Apr. 2024

  医生物学研究所　病原体安全管理委員会
• From 01 Apr. 2024

  医生物学研究所　安全衛生委員会
• From 01 Apr. 2024

  医生物学研究所　感染症モデル研究センター運営委員
• From 01 Apr. 2024

  医生物学研究所　衛生管理者
• From 01 Apr. 2023

  医生物学研究所　医の倫理委員会　副委員長
• From 01 Apr. 2023

  医生物学研究所　共同利用機器等委員会　委員
• From 01 Feb. 2023, To 31 Jul. 2023

  医学研究科　運営委員
• From 01 Feb. 2023, To 31 Jul. 2023

  医学研究科　選定委員長
• From 01 Aug. 2022, To 31 Jul. 2023

  医学研究科　選定委員
• From 01 Apr. 2022, To 31 Mar. 2024

  医生物学研究所　化学物質管理委員会　委員
• From 01 Apr. 2022

  医生物学研究所　再生実験動物施設飼育室施設運営委員会 委員
• From 01 Apr. 2022

  医生物学研究所　動物実験委員会　委員

Academic, Social Contribution

Social Contribution

• 膠原病についての基礎知識と最近の話題

  Lecturer

  長浜市保健所, From Nov. 2005