Basic Information

Faculty

• 薬学部

Professional Memberships

• 日本循環器学会
• 日本ケミカルバイオロジー学会
• がん分子標的治療学会
• 日本癌学会
• 日本生化学会
• 日本化学会
• 日本農芸化学会
• 日本薬学会
• The Japanese Circulation Society
• Japanese Society for Chemical Biology
• The Japanase Association for Molecular Target Therapy of Cancer
• Japanse Cancer Association
• The Japanese Biochemical Society
• The Chemical Society of Japan
• and Agrochemistry
• Biotechnology
• Japanese Society for Bioscience
• The Pharmaceutical Society of Japan
• The Japanese Society of Pharmacognosy

Academic Degree

• (Keio University)
• Ph.D.(Keio University)

Academic Resume (Graduate Schools)

• Keio University, 大学院理工学研究科後期博士課程生体医工学専攻, 修了
• Keio University, 大学院理工学研究科前期博士課程化学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 慶應義塾大学, 理工学部化学科, 卒業

High School

• High School

  岡山県立井原高等学校

Research History

• From 2007

  ：京都大学大学院薬学研究科・教授
• From 2007

  ：Professor, Department of System Chemotherapy and Molecular Sciences, Division of Bioinformatics and Chemcial Genomics, Graduate School of Pharmaceutical Sciences, Kyoto University
• From 2003

  ：理化学研究所 副主任研究員, チームリーダー（ケミカルバイオロジー研究）
• From 2003

  ：Senior Scientist, Team Leader, RIKEN Institute
• From 1998, To 2000

  ：MIT 客員研究員
• From 1998, To 2000

  ：Visiting Scientist, MIT
• From 1994

  ：理化学研究所 研究員
• From 1994

  ：Research Scientist, RIKEN Institute
• 理化学研究所 客員研究員
• Visiting Professor, RIKEN Institute

ID,URL

• ORCID ID

  0000-0002-4293-7331

• J-Global ID

  200901007856587226

• External link

  http://www.pharm.kyoto-u.ac.jp/sc-molsci/

Website(s) (URL(s))

• http://www.pharm.kyoto-u.ac.jp/sc-molsci/

researchmap URL

• https://researchmap.jp/Hideaki_Kakeya

Research

Research Topics, Overview of the research

• Research Topics

  1. Advanced chemical biology research for establishing system chemotherapy in order to cure multi-factorial diseases; e.g. cancer, myocardial infarction, immunodeficiency, diabetes, and neuronal diseases., 2. HCS (high-contents screening) and HTS (high throughput screening) for identifying useful small molecules (bioprobes)., 3. Natural product chemistry for mining novel bioactive small molecules. and medicinal chemistry, 4. Biosynthetic studies of natural products and their application to combinatorial biosynthesis

• Overview of the research

  Chemical biology based on forward/reverse chemical genetics is a new research paradigm that accelerates drug development and the functional analysis of genes and proteins. Diversity of small molecules is one of the most important points to facilitate the success of chemical biology. As such, we have been screening two types of chemical libraries: a natural products library and a synthetic chemical library. After identifying bioactive small molecules, their modes of actions and targets are investigated using a chemical biology-based approach. So far, several bioactive small molecules we have discoved have been alreday commercially available.

Research Interests

• 生薬学
• インフォマティクス
• 再生医療
• メタボローム解析
• システムケモセラピー
• ケミカルゲノミクス
• 天然物化学
• ケミカルバイオロジー
• natural medicine
• informatics
• regenerative medicine
• metabolome
• system chemotherapy
• chemical genomics
• natural product chemistry
• chemical biology
• medicinal chemistry

Research Areas

• Life sciences, Pharmaceuticals - chemistry and drug development
• Life sciences, Bioorganic chemistry
• Nanotechnology/Materials, Molecular biochemistry

Papers

• Pharmacologic characterization of TBP1901, a prodrug form of aglycone curcumin, and CRISPR-Cas9 screen for therapeutic targets of aglycone curcumin.

  Tomoyuki Abe; Yoshihito Horisawa; Osamu Kikuchi; Hitomi Ozawa-Umeta; Atsuhiro Kishimoto; Yasuhiro Katsuura; Atsushi Imaizumi; Tadashi Hashimoto; Kotaro Shirakawa; Akifumi Takaori-Kondo; Kosuke Yusa; Tadashi Asakura; Hideaki Kakeya; Masashi Kanai

  European journal of pharmacology, 15 Nov. 2022

  
• Highly absorptive curcumin reduces serum oxidatively modified atherosclerotic LDL levels with Mild COPD

  Funamoto Masafumi; Sunagawa Yoichi; Katanasaka Yasufumi; Miyazaki Yusuke; Imaizumi Atsushi; Kakeya Hideaki; Yamakage Hajime; Satoh-Asahara Noriko; Komiyama Maki; Wada Hiromichi; Hasegawa Koji; Morimoto Tatsuya

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2017, Peer-reviewed

  
• Development and application of highly sensitive labeling reagents for amino acids

  Takefumi Kuranaga; Hideaki Kakeya

  Methods in Enzymol., Mar. 2022, Peer-reviewed

  
• Separation of amyloid β fragment peptides with racemised and isomerised aspartic acid residues using an original chiral resolution labeling reagent

  Makoto Ozaki; Motoshi Shimotsuma; Takefumi Kuranaga; Hideaki Kakeya; Tsunehisa Hirose

  The Analyst, 2023

  
• Solid-phase total synthesis and structural confirmation of antimicrobial longicatenamide A

  Takumi Matsumoto; Takefumi Kuranaga; Yuto Taniguchi; Weicheng Wang; Hideaki Kakeya

  Beilstein Journal of Organic Chemistry, 18 Nov. 2022

  
• Separation and identification of the dl-forms of short-chain peptides using a new chiral resolution labeling reagent

  Makoto Ozaki; Tomomi Kuwayama; Tsunehisa Hirose; Motoshi Shimotsuma; Akira Hashimoto; Takefumi Kuranaga; Hideaki Kakeya

  Analytical and Bioanalytical Chemistry, Jun. 2022

  
• FK506-binding protein, FKBP12, promotes serine utilization and negatively regulates threonine deaminase in fission yeast

  Mayuki Sasaki; Shinichi Nishimura; Yoko Yashiroda; Akihisa Matsuyama; Hideaki Kakeya; Minoru Yoshida

  iScience, Dec. 2022

  
• ChemInform Abstract: Structure Elucidation of Verucopeptin, a HIF-1 Inhibitory Polyketide-Hexapeptide Hybrid Metabolite from an Actinomycete.

  Aya Yoshimura; Shinichi Nishimura; Saori Otsuka; Akira Hattori; Hideaki Kakeya

  ChemInform, 03 Mar. 2016

  
• ChemInform Abstract: Total Synthesis and Structure Revision of Mirubactin, and Its Iron Binding Activity.

  Shinji Kishimoto; Shinichi Nishimura; Hideaki Kakeya

  ChemInform, Mar. 2016

  
• ChemInform Abstract: Total Synthesis of the Proposed Structure of Heronamide C.

  Kohei Sakanishi; Shunya Itoh; Ryosuke Sugiyama; Shinichi Nishimura; Hideaki Kakeya; Yoshiharu Iwabuchi; Naoki Kanoh

  ChemInform, Nov. 2014

  
• ChemInform Abstract: Tumescenamide C, an Antimicrobial Cyclic Lipodepsipeptide from Streptomyces sp.

  Shinji Kishimoto; Yuta Tsunematsu; Shinichi Nishimura; Yutaka Hayashi; Akira Hattori; Hideaki Kakeya

  ChemInform, Oct. 2012

  
• ChemInform Abstract: Novel Natural Products Open the Door of Chemical Biology and Medicinal Chemistry

  Hideaki Kakeya; Shinichi Nishimura

  ChemInform, Aug. 2010

  
• Chemical Interactions of Cryptic Actinomycete Metabolite 5‐Alkyl‐1,2,3,4‐tetrahydroquinolines through Aggregate Formation

  Ryosuke Sugiyama; Takahiro Nakatani; Shinichi Nishimura; Kei Takenaka; Taro Ozaki; Shumpei Asamizu; Hiroyasu Onaka; Hideaki Kakeya

  Angewandte Chemie, 16 Sep. 2019

  
• Developing crosslinkers specific for epimerization domain in NRPS initiation modules to evaluate mechanism

  Woojoo E. Kim; Fumihiro Ishikawa; Rebecca N. Re; Takehiro Suzuki; Naoshi Dohmae; Hideaki Kakeya; Genzoh Tanabe; Michael D. Burkart

  RSC Chemical Biology, 2022

  
• プロドラッグ型クルクミンCMGによる腸内細菌叢変化と多発性硬化症自己免疫モデルの抑制(Curcumin monoglucuronide(CMG) affects the gut microbiota, suppressing an autoimmune model for multiple sclerosis)

  スンダル・カドカ; 尾村 誠一; 佐藤 文孝; 中村 優美和; 甲木 蒼紫; 崎山 奈美江; 朴 雅美; 西尾 和人; 掛谷 秀昭; 角田 郁生

  近畿大学医学雑誌, Dec. 2021

  
• P-538 TOTAL SYNTHESIS OF PANEPOPHENANTHRIN AND BIOLOGICAL ACTIVITIES OF ITS DERIVATIVES

  Matsuzawa Masayoshi; Yamaguchi Junichiro; Shoji Mitsuru; Kakeya Hideaki; Osada Hiroyuki; Hayashi Yujiro

  International Symposium on the Chemistry of Natural Products, 23 Jul. 2006

  
• P-62 Enantio- and Diastereoselective Total Synthesis of (+)-Panepophenanthrin, a Ubiquitin- Activating Enzyme Inhibitor, and Biological Properties of Its New Derivatives

  Hayashi Yujiro; Matsuzawa Masayoshi; Yamaguchi Junichiro; Shoji Mitsuru; Kakeya Hideaki; Onose Rie; Osada Hiroyuki

  Symposium on the Chemistry of Natural Products, symposium papers, 24 Aug. 2007

  
• 5 The Asymmetric Total Synthesis of Lucilactaene, a Cell Cycle Inhibitor in p53-Transfected Cancer Cells

  Yamaguchi Junichiro; Kakeya Hideaki; Shoji Mitsuru; Osada Hiroyuki; Hayashi Yujiro

  Symposium on the Chemistry of Natural Products, symposium papers, 15 Sep. 2005

  
• P-43 Total Synthesis of EI-1941-1, EI-1941-2, and EI-1941-3 and The Biological Properties of Their Derivatives

  Shoji Mitsuru; Uno Takao; Hayashi Yujiro; Kakeya Hideaki; Onose Rie; Osada Hiroyuki

  Symposium on the Chemistry of Natural Products, symposium papers, 15 Sep. 2005

  
• 98(P-30) Total Syntheses of Fumagillin, RK-805 and FR65814 Using Proline Catalyzed Asymmetric α-Aminoxylation

  Yamaguchi Junichiro; Sumiya Tatsunobu; Hibino Kazuhiro; Shoji Mitsuru; Kakeya Hideaki; Osada Hiroyuki; Hayashi Yujiro

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Oct. 2004

  
• 55(P-29) Different Reaction Modes for the Oxidative Dimerization of Epoxyquinols and Epoxyquinones

  Shoji Mitsuru; Imai Hiroki; Hayashi Yujiro; Shiina Isamu; Kakeya Hideaki; Osada Hiroyuki

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Oct. 2004

  
• 14 Total synthesis of azaspirene, a novel angiogenesis inhibitor

  Shoji Mitsuru; Yamaguchi Shinpei; Mukaiyama Takasuke; Goto Hiroaki; Yamaguchi Junichiro; Asami Yukihiro; Kakeya Hideaki; Osada Hiroyuki; Hayashi Yujiro

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Sep. 2003

  
• 35 Epoxyquinols A and B, Novel Angiogenesis Inhibitors Produced by a Fungus

  Kakeya Hideaki; Onose Rie; Yoshida Arika; Koshino Hiroyuki; Kobayashi Kimiko; Osada Hiroyuki

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Sep. 2002

  
• 3 Total Synthesis of Epoxyquinol A

  Shoji Mitsuru; Yamaguchi Junichiro; Kishida Satoshi; Takeda Mitsuhiro; Kakeya Hideaki; Osada Hiroyuki; Hayashi Yujiro

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Sep. 2002

  
• 61(P-18) Lucilactaene, a new anticancer drug produced by Fusarium sp.

  Kakeya Hideaki; Kageyama Shun-Ichiro; Nie Lin; Onose Rie; Osada Hiroyuki

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Sep. 2001

  
• 101(P45) Studies on Novel Apoptosis Inducer Cytotrienins

  Zhang H.-p.; Kakeya H.; Osada H.

  Symposium on the Chemistry of Natural Products, symposium papers, 20 Jul. 1997

  
• 9 ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL ACTIVITIES OF NOVEL MAMMALIAN CELL CYCLE INHIBITORS, SPIROTRYPROSTATINS A & B, TRYPROSTATINS A & B AND RELATED NEW DIKETOPIPERAZINE DERIVATIVES PRODUCED BY A FUNGUS, ASPERGILLUS FUMIGATUS

  Cui Cheng-Bin; Kakeya Hideaki; Osada Hiroyuki

  Symposium on the Chemistry of Natural Products, symposium papers, 02 Sep. 1996

  
• 75 SYNTHESIS OF OPTICALLY ACTIVE NATURAL PRODUCTS BY THE AID OF LIPASES

  Sugai T.; Kakeya H.; Yamada H.; Matsumoto K.; Ohsawa S.; Suzuki N.; Ohta H.

  Symposium on the Chemistry of Natural Products, symposium papers, 25 Sep. 1990

  
• Toward the Creation of Induced Pluripotent Small (iPS) Molecules: Establishment of a Modular Synthetic Strategy for the Heronamide C-type Polyene Macrolactams and Their Conformational and Reactivity Analysis

  Naoki Kanoh; Yuta Terajima; Suguru Tanaka; Ryusei Terashima; Hiromichi Nishiyama; Shota Nagasawa; Yusuke Sasano; Yoshiharu Iwabuchi; Shinichi Nishimura; Hideaki Kakeya

  The Journal of Organic Chemistry, 03 Dec. 2021, Peer-reviewed

  
• Design, Synthesis, and Antifungal Activity of 16,17-Dihydroheronamide C and ent-Heronamide C

  Naoki Kanoh; Ryusei Terashima; Hiromichi Nishiyama; Yuta Terajima; Shota Nagasawa; Yusuke Sasano; Yoshiharu Iwabuchi; Hiroaki Saito; Syusuke Egoshi; Kosuke Dodo; Mikiko Sodeoka; Chengqian Pan; Yoshinobu Ikeuchi; Shinichi Nishimura; Hideaki Kakeya

  The Journal of Organic Chemistry, 03 Dec. 2021

  
• Design, synthesis, and target identification of new hypoxia-inducible factor 1 (HIF-1) inhibitors containing 1-alkyl-1H-pyrazole-3-carboxamide moiety.

  Marina Sakai; Nobuaki Takahashi; Hiroaki Ikeda; Yutaka Furutani; Shoko Higuchi; Takehiro Suzuki; Naoshi Dohmae; Sayaka Kobayashi; Hiroshi Harada; Soichi Kojima; Tomokazu Matsuura; Akira Hattori; Hideaki Kakeya

  Bioorganic & medicinal chemistry, 15 Sep. 2021

  
• Curcumin β-D-Glucuronide Modulates an Autoimmune Model of Multiple Sclerosis with Altered Gut Microbiota in the Ileum and Feces.

  Sundar Khadka; Seiichi Omura; Fumitaka Sato; Kazuto Nishio; Hideaki Kakeya; Ikuo Tsunoda

  Frontiers in cellular and infection microbiology, 2021

  
• 高含有クルクミン製剤Theracurmin30%はTheracurmin10%と比較して経口吸収性は同等であった

  清水 聡史; 砂川 陽一; 清水 果奈; Nurmila Sari; 船本 雅文; 宮崎 雄輔; 刀坂 泰史; 森本 恵理子; 小沢 瞳; 今泉 厚; 上野 盛夫; 小見山 麻紀; 掛谷 秀昭; 和田 啓道; 島津 章; 長谷川 浩二; 森本 達也

  日本栄養・食糧学会大会講演要旨集, Apr. 2019

  
• Curcumin glucuronideのp300-HAT活性及び心筋細胞肥大に対する効果の検討

  源平 麻衣; 砂川 陽一; 船本 雅文; 清水 果奈; 刀坂 泰史; 掛谷 秀昭; 和田 啓道; 島津 章; 長谷川 浩二; 森本 達也

  日本抗加齢医学会総会プログラム・抄録集, Jun. 2017

  
• 耐糖能障害患者における高吸収クルクミンの効果について

  船本 雅文; 砂川 陽一; 刀坂 泰史; 宮崎 雄輔; 今泉 厚; 掛谷 秀昭; 山陰 一; 浅原 哲子; 小見山 麻紀; 和田 啓道; 長谷川 浩二; 森本 達也

  日本抗加齢医学会総会プログラム・抄録集, Jun. 2016

  
• Inhibition of efflux pumps aids small-molecule probe-based fluorescence labeling and imaging in the Gram-negative bacterium Escherichia coli.

  Fumihiro Ishikawa; Sho Konno; Katsuki Takashima; Hideaki Kakeya; Genzoh Tanabe

  Organic & biomolecular chemistry, 27 Oct. 2021

  
• Studies on Saccharothriolides A-C, Novel Phenyl-substituted 10-Membered Macrolides from a Rare Actinomycete Saccharothrix sp.

  Lu Shan; Kakeya Hideaki; Nishimura Shinichi; Hirai Go; Ito Masashi; Kawahara Teppei; Izumikawa Miho; Sodeoka Mikiko; Shin-ya Kazuo; Tsuchida Toshio

  Symposium on the Chemistry of Natural Products, symposium papers, 2015

  
• 13 The Asymmetric Total Synthesis of(+)-Cytotrienin A, an Ansamycin-type Anticancer Drug(Oral Presentation)

  Hayashi Yujiro; Mitsuru Shoji; Ishikawa Hayato; Yamaguchi Junichiro; Tamura Tomohiro; Imai Hiroaki; Nishigaya Yosuke; Takabe Kenichi; Kakeya Hideaki; Osada Hiroyuki

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Sep. 2008

  
• Identification and Total Synthesis of an Unstable Anticancer Macrolide Presaccharothriolide Z Produced by Saccharothrix sp. A1506

  Takefumi Kuranaga; Miho Tamura; Hiroaki Ikeda; Sakahiro Terada; Yusuke Nakagawa; Hideaki Kakeya

  Organic Letters, 17 Sep. 2021

  
• Curcumin, an Inhibitor of p300-HAT Activity, Suppresses the Development of Hypertension-Induced Left Ventricular Hypertrophy with Preserved Ejection Fraction in Dahl Rats.

  Yoichi Sunagawa; Masafumi Funamoto; Kana Shimizu; Satoshi Shimizu; Nurmila Sari; Yasufumi Katanasaka; Yusuke Miyazaki; Hideaki Kakeya; Koji Hasegawa; Tatsuya Morimoto

  Nutrients, 29 Jul. 2021

  
• Chemoproteomics profiling of surfactin-producing nonribosomal peptide synthetases in living bacterial cells.

  Fumihiro Ishikawa; Sho Konno; Chiharu Uchida; Takehiro Suzuki; Katsuki Takashima; Naoshi Dohmae; Hideaki Kakeya; Genzoh Tanabe

  Cell chemical biology, 09 Jun. 2021

  
• An Atypical Arginine Dihydrolase Involved in the Biosynthesis of Cyclic Hexapeptide Longicatenamides.

  Chao Liu; Junko Hashimoto; Kei Kudo; Kazuo Shin-Ya; Hideaki Kakeya

  Chemistry, an Asian journal, 01 Jun. 2021

  
• Genomic and Targeted Approaches Unveil the Cell Membrane as a Major Target of the Antifungal Cytotoxin Amantelide A.

  Lobna A Elsadek; James H Matthews; Shinichi Nishimura; Takahiro Nakatani; Airi Ito; Tongjun Gu; Danmeng Luo; Lilibeth A Salvador-Reyes; Valerie J Paul; Hideaki Kakeya; Hendrik Luesch

  Chembiochem : a European journal of chemical biology, 14 May 2021

  
• Longicatenamides A-D, Two Diastereomeric Pairs of Cyclic Hexapeptides Produced by Combined-culture of Streptomyces sp. KUSC_F05 and Tsukamurella pulmonis TP-B0596.

  Yulu Jiang; Takumi Matsumoto; Takefumi Kuranaga; Shan Lu; Weicheng Wang; Hiroyasu Onaka; Hideaki Kakeya

  The Journal of antibiotics, May 2021

  
• Heterogenous chemosensitivity of a panel of organoid lines derived from small cell neuroendocrine carcinoma of the uterine cervix.

  Mie Tanaka; Jumpei Kondo; Kensuke Kaneko; Hiroko Endo; Kunishige Onuma; Roberto Coppo; Masamune Masuda; Shoji Kamiura; Kiyoshi Yoshino; Yutaka Ueda; Hideaki Kakeya; Tadashi Kimura; Masahiro Inoue

  Human cell, May 2021

  
• Correction to: Heterogenous chemosensitivity of a panel of organoid lines derived from small cell neuroendocrine carcinoma of the uterine cervix.

  Mie Tanaka; Jumpei Kondo; Kensuke Kaneko; Hiroko Endo; Kunishige Onuma; Roberto Coppo; Masamune Masuda; Shoji Kamiura; Kiyoshi Yoshino; Yutaka Ueda; Hideaki Kakeya; Tadashi Kimura; Masahiro Inoue

  Human cell, May 2021

  
• Amphiol, an Antifungal Fungal Pigment from Pseudogymnoascus sp. PF1464.

  Kohei Fujita; Misa Ikuta; Shinichi Nishimura; Ryosuke Sugiyama; Aya Yoshimura; Hideaki Kakeya

  Journal of natural products, 23 Apr. 2021

  
• Retro-aza-Michael reaction of an o-aminophenol adduct in protic solvents inspired by natural products.

  Kei Takenaka; Kensuke Kaneko; Nobuaki Takahashi; Shinichi Nishimura; Hideaki Kakeya

  Bioorganic & medicinal chemistry, 01 Apr. 2021

  
• Application of the highly sensitive labeling reagent to the structural confirmation of readily isomerizable peptides.

  Chengqian Pan; Takefumi Kuranaga; Hideaki Kakeya

  Journal of natural medicines, Mar. 2021

  
• The effects of 5-OP-RU stereochemistry on its stability and MAIT-MR1 axis.

  Takuro Matsuoka; Chihiro Motozono; Akira Hattori; Hideaki Kakeya; Sho Yamasaki; Shinya Oishi; Hiroaki Ohno; Shinsuke Inuki

  Chembiochem : a European journal of chemical biology, 15 Feb. 2021

  
• Amycolapeptins A and B, Cyclic Nonadepsipeptides Produced by Combined-culture of Amycolatopsis sp. and Tsukamurella pulmonis.

  Chengqian Pan; Takefumi Kuranaga; Xun Cao; Takehiro Suzuki; Naoshi Dohmae; Naoya Shinzato; Hiroyasu Onaka; Hideaki Kakeya

  The Journal of organic chemistry, 15 Jan. 2021

  
• Highly Sensitive Determination of Amino Acids by LC-MS under Neutral Conditions.

  Ryota Morimoto; Takumi Matsumoto; Mayuri Minote; Masayuki Yanagisawa; Ryotaro Yamada; Takefumi Kuranaga; Hideaki Kakeya

  Chemical & pharmaceutical bulletin, 2021

  
• Total synthesis of thioamycolamide A via a biomimetic route.

  Chengqian Pan; Takefumi Kuranaga; Hideaki Kakeya

  Organic & biomolecular chemistry, 07 Nov. 2020

  
• Highly Sensitive Labeling Reagents for Scarce Natural Products.

  Takefumi Kuranaga; Mayuri Minote; Ryota Morimoto; Chengqian Pan; Haruka Ogawa; Hideaki Kakeya

  ACS chemical biology, 18 Sep. 2020

  
• Miclxin, a Novel MIC60 Inhibitor, Induces Apoptosis via Mitochondrial Stress in β-Catenin Mutant Tumor Cells.

  Hiroaki Ikeda; Makoto Muroi; Yasumitsu Kondoh; Shumpei Ishikawa; Hideaki Kakeya; Hiroyuki Osada; Masaya Imoto

  ACS chemical biology, 21 Aug. 2020

  
• Serine catabolism produces ROS, sensitizes cells to actin dysfunction, and suppresses cell growth in fission yeast.

  Akihiko Kanou; Shinichi Nishimura; Toshitsugu Tabuchi; Akihisa Matsuyama; Minoru Yoshida; Taira Kato; Hideaki Kakeya

  The Journal of antibiotics, Aug. 2020, Peer-reviewed

  
• Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans.

  Jean-Michel Fustin; Shiqi Ye; Christin Rakers; Kensuke Kaneko; Kazuki Fukumoto; Mayu Yamano; Marijke Versteven; Ellen Grünewald; Samantha J Cargill; T Katherine Tamai; Yao Xu; Maria Luísa Jabbur; Rika Kojima; Melisa L Lamberti; Kumiko Yoshioka-Kobayashi; David Whitmore; Stephanie Tammam; P Lynne Howell; Ryoichiro Kageyama; Takuya Matsuo; Ralf Stanewsky; Diego A Golombek; Carl Hirschie Johnson; Hideaki Kakeya; Gerben van Ooijen; Hitoshi Okamura

  Communications biology, 04 Jun. 2020, Peer-reviewed

  
• Methylation deficiency disrupts biological rhythms from bacteria to humans.

  Jean-Michel Fustin; Shiqi Ye; Christin Rakers; Kensuke Kaneko; Kazuki Fukumoto; Mayu Yamano; Marijke Versteven; Ellen Grünewald; Samantha J Cargill; T Katherine Tamai; Yao Xu; Maria Luísa Jabbur; Rika Kojima; Melisa L Lamberti; Kumiko Yoshioka-Kobayashi; David Whitmore; Stephanie Tammam; P Lynne Howell; Ryoichiro Kageyama; Takuya Matsuo; Ralf Stanewsky; Diego A Golombek; Carl Hirschie Johnson; Hideaki Kakeya; Gerben van Ooijen; Hitoshi Okamura

  Communications biology, 06 May 2020

  
• Curcumin β-D-glucuronide exhibits anti-tumor effects on oxaliplatin-resistant colon cancer with less toxicity in vivo.

  Hitomi Ozawa-Umeta; Atsuhiro Kishimoto; Atsushi Imaizumi; Tadashi Hashimoto; Tadashi Asakura; Hideaki Kakeya; Masashi Kanai

  Cancer science, May 2020

  
• The Synthetic Curcumin Analogue GO-Y030 Effectively Suppresses the Development of Pressure Overload-induced Heart Failure in Mice.

  Kana Shimizu; Yoichi Sunagawa; Masafumi Funamoto; Hiroki Wakabayashi; Mai Genpei; Yusuke Miyazaki; Yasufumi Katanasaka; Nurmila Sari; Satoshi Shimizu; Ayumi Katayama; Hiroyuki Shibata; Yoshiharu Iwabuchi; Hideaki Kakeya; Hiromichi Wada; Koji Hasegawa; Tatsuya Morimoto

  Scientific reports, 28 Apr. 2020, Peer-reviewed

  
• Thioamycolamides A-E, Sulfur-Containing Cycliclipopeptides Produced by the Rare Actinomycete Amycolatopsis sp.

  Chengqian Pan; Takefumi Kuranaga; Chao Liu; Shan Lu; Naoya Shinzato; Hideaki Kakeya

  Organic letters, 17 Apr. 2020, Peer-reviewed

  
• Different localization of lysosomal-associated membrane protein 1 (LAMP1) in mammalian cultured cell lines.

  Kosuke Baba; Sara Kuwada; Ayaka Nakao; Xuebing Li; Naoaki Okuda; Ai Nishida; Satoshi Mitsuda; Natsuki Fukuoka; Hideaki Kakeya; Takao Kataoka

  Histochemistry and cell biology, Apr. 2020, Peer-reviewed

  
• Total Synthesis and Antimicrobial Activity of Tumescenamide C and Its Derivatives.

  Nobuaki Takahashi; Kensuke Kaneko; Hideaki Kakeya

  The Journal of organic chemistry, 20 Mar. 2020

  
• Cryptic Chemical Communication: Secondary Metabolic Responses Revealed by Microbial Co-culture.

  Chao Liu; Hideaki Kakeya

  Chemistry, an Asian journal, 03 Feb. 2020

  
• Ubiquitin carboxyl-terminal hydrolase L1 promotes hypoxia-inducible factor 1-dependent tumor cell malignancy in spheroid models

  Li, X.; Hattori, A.; Takahashi, S.; Goto, Y.; Harada, H.; Kakeya, H.

  Cancer Science, 2020, Peer-reviewed

  
• Effects of Highly Absorbable Curcumin in Patients with Impaired Glucose Tolerance and Non-Insulin-Dependent Diabetes Mellitus.

  Masafumi Funamoto; Kana Shimizu; Yoichi Sunagawa; Yasufumi Katanasaka; Yusuke Miyazaki; Hideaki Kakeya; Hajime Yamakage; Noriko Satoh-Asahara; Hiromichi Wada; Koji Hasegawa; Tatsuya Morimoto

  Journal of diabetes research, 2019, Peer-reviewed

  
• Precious Microorganisms as Productive Resources: Marine-derived Microorganisms and Combined-Culture

  Hideaki Kakeya; Takefumi Kuranaga

  Comprehensive Natural Products III, 2019, Peer-reviewed

  
• Enhancement of saccharothriolide production and discovery of a new metabolite, saccharothriolide C 2 , by combined-culture of Saccharothrix sp. and Tsukamurella pulmonis

  Jiang, Y.; Lu, S.; Hirai, G.; Kato, T.; Onaka, H.; Kakeya, H.

  Tetrahedron Letters, 2019, Peer-reviewed

  
• Development of an anti-hepatitis B virus (HBV) agent through the structure-activity relationship of the interferon-like small compound CDM-3008

  Takahashi, N.; Hayashi, K.; Nakagawa, Y.; Furutani, Y.; Toguchi, M.; Shiozaki-Sato, Y.; Sudoh, M.; Kojima, S.; Kakeya, H.

  Bioorganic and Medicinal Chemistry, 2019, Peer-reviewed

  
• Identification of the common biosynthetic gene cluster for both antimicrobial streptoaminals and antifungal 5-alkyl-1,2,3,4-tetrahydroquinolines

  Ozaki, T.; Sugiyama, R.; Shimomura, M.; Nishimura, S.; Asamizu, S.; Katsuyama, Y.; Kakeya, H.; Onaka, H.

  Organic and Biomolecular Chemistry, 2019, Peer-reviewed

  
• An interferon-like small chemical compound CDM-3008 suppresses hepatitis B virus through induction of interferon-stimulated genes

  Furutani, Y.; Toguchi, M.; Shiozaki-Sato, Y.; Qin, X.-Y.; Ebisui, E.; Higuchi, S.; Sudoh, M.; Suzuki, H.; Takahashi, N.; Watashi, K.; Wakita, T.; Kakeya, H.; Kojima, S.

  PLoS ONE, 2019, Peer-reviewed

  
• Chemical Interactions of Cryptic Actinomycete Metabolite 5-Alkyl-1,2,3,4-tetrahydroquinolines through Aggregate Formation

  Sugiyama, R.; Nakatani, T.; Nishimura, S.; Takenaka, K.; Ozaki, T.; Asamizu, S.; Onaka, H.; Kakeya, H.

  Angewandte Chemie - International Edition, 2019, Peer-reviewed

  
• Isolation, Structure Elucidation, and Conformational Regulation of Myropeptins, Lipopeptides from the Fungus Myrothecium roridum

  Yoshimura, A.; Nishimura, S.; Suzuki, T.; Hattori, A.; Dohmae, N.; Kato, T.; Kakeya, H.

  Organic Letters, 2019, Peer-reviewed

  
• Total synthesis of verucopeptin, an inhibitor of hypoxia-inducible factor 1 (HIF-1)

  Takahashi, N.; Hayashi, H.; Poznaks, V.; Kakeya, H.

  Chemical Communications, 2019, Peer-reviewed

  
• Theonellamide A, a marine-sponge-derived bicyclic peptide, binds to cholesterol in aqueous DMSO: Solution NMR-based analysis of peptide-sterol interactions using hydroxylated sterol

  Cornelio, K.; Espiritu, R.A.; Hanashima, S.; Todokoro, Y.; Malabed, R.; Kinoshita, M.; Matsumori, N.; Murata, M.; Nishimura, S.; Kakeya, H.; Yoshida, M.; Matsunaga, S.

  Biochimica et Biophysica Acta - Biomembranes, 2019, Peer-reviewed

  
• Activity-based protein profiling of non-ribosomal peptide synthetases

  Ishikawa, F.; Tanabe, G.; Kakeya, H.

  Current Topics in Microbiology and Immunology, 2019, Peer-reviewed

  
• Erratum to: The Inhibitory Effects of Crucumin Glucuronide on p300-HAT Activity and Hypertrophic Phenylephrine-Induced Responses in Cardiomyocytes.

  Mai Genpei; Yoichi Sunagawa; Masafumi Funamoto; Kana Shimizu; Yusuke Miyazaki; Yasufumi Katanasaka; Nobuaki Takahashi; Hideaki Kakeya; Hiromichi Wada; Koji Hasegawa; Tatsuya Morimoto

  European cardiology, Dec. 2018, Peer-reviewed

  
• Curcumin and its demethoxy derivatives possess p300 HAT inhibitory activity and suppress hypertrophic responses in cardiomyocytes.

  Yoichi Sunagawa; Masafumi Funamoto; Shogo Sono; Kana Shimizu; Satoshi Shimizu; Mai Genpei; Yusuke Miyazaki; Yasufumi Katanasaka; Eriko Morimoto; Morio Ueno; Maki Komiyama; Hideaki Kakeya; Hiromichi Wada; Koji Hasegawa; Tatsuya Morimoto

  Journal of pharmacological sciences, Apr. 2018, Peer-reviewed

  
• Discovery of Presaccharothriolide X, a Retro-Michael Reaction Product of Saccharothriolide B, from the Rare Actinomycete Saccharothrix sp. A1506

  Lu, S.; Nishimura, S.; Takenaka, K.; Ito, M.; Kato, T.; Kakeya, H.

  Organic Letters, 2018, Peer-reviewed

  
• The Inhibitory Effects of Crucumin Glucuronide on p300-HAT Activity and Hypertrophic Phenylephrine-Induced Responses in Cardiomyocytes.

  Mai Genpei; Yoichi Sunagawa; Masafumi Funamoto; Kana Shimizu; Yusuke Miyazaki; Yasufumi Katanasaka; Nobuaki Takahashi; Hideaki Kakeya; Hiromichi Wada; Koji Hasegawa; Tatsuya Morimoto

  European cardiology, Dec. 2017, Peer-reviewed

  
• The chemical biology of natural product biosynthesis: chemical tools for the proteomic analysis of nonribosomal peptide synthetases

  Fumihiro Ishikawa; Hideaki Kakeya

  Frontiers in Nat. Prod. Chem., 2017, Peer-reviewed, Invited

  
• Precursor-directed in situ synthesis of Saccharothriolides G and H by the Actinomycete Saccharothrix sp. A1506

  Lu, S.; Nishimura, S.; Ito, M.; Kato, T.; Kakeya, H.

  Journal of Antibiotics, 2017, Peer-reviewed

  
• Curcumin β-D-glucuronide plays an important role to keep high levels of free-form curcumin in the blood

  Ozawa, H.; Imaizumi, A.; Sumi, Y.; Hashimoto, T.; Kanai, M.; Makino, Y.; Tsuda, T.; Takahashi, N.; Kakeya, H.

  Biological and Pharmaceutical Bulletin, 2017, Peer-reviewed

  
• A Chemoproteomics Approach to Investigate Phosphopantetheine Transferase Activity at the Cellular Level

  Konno, S.; Ishikawa, F.; Suzuki, T.; Dohmae, N.; Kakeya, H.; Tanabe, G.

  ChemBioChem, 2017, Peer-reviewed

  
• Visualizing the Adenylation Activities and Protein–Protein Interactions of Aryl Acid Adenylating Enzymes

  Ishikawa, F.; Kasai, S.; Kakeya, H.; Tanabe, G.

  ChemBioChem, 2017, Peer-reviewed

  
• In Vitro Investigation of Crosstalk between Fatty Acid and Polyketide Synthases in the Andrimid Biosynthetic Assembly Line

  Fumihiro Ishikawa; Hiroyasu Sugimoto; Hideaki Kakeya

  CHEMBIOCHEM, Nov. 2016, Peer-reviewed

  
• Sterol-dependent membrane association of the marine sponge-derived bicyclic peptide Theonellamide A as examined by H-1 NMR

  Kimberly Cornelio; Rafael Atillo Espiritu; Yasuto Todokoro; Shinya Hanashima; Masanao Kinoshita; Nobuaki Matsumori; Michio Murata; Shinichi Nishimura; Hideaki Kakeya; Minoru Yoshida; Shigeki Matsunaga

  BIOORGANIC & MEDICINAL CHEMISTRY, Nov. 2016, Peer-reviewed

  
• LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis

  Chan Joo Yeom; Lihua Zeng; Yoko Goto; Akiyo Morinibu; Yuxi Zhu; Kazumi Shinomiya; Minoru Kobayashi; Satoshi Itasaka; Michio Yoshimura; Cheol-Goo Hur; Hideaki Kakeya; Ester M. Hammond; Masahiro Hiraoka; Hiroshi Harada

  ONCOTARGET, Oct. 2016, Peer-reviewed

  
• Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD

  Masafumi Funamoto; Yoichi Sunagawa; Yasufumi Katanasaka; Yusuke Miyazaki; Atsushi Imaizumi; Hideaki Kakeya; Hajime Yamakage; Noriko Satoh-Asahara; Maki Komiyama; Hiromichi Wada; Koji Hasegawa; Tatsuya Morimoto

  International Journal of COPD, 26 Aug. 2016, Peer-reviewed

  
• Discovery and Total Synthesis of Streptoaminals: Antimicrobial [5,5]-Spirohemiaminals from the Combined-Culture of Streptomyces nigrescens and Tsukamurella pulmonis

  Ryosuke Sugiyama; Shinichi Nishimura; Taro Ozaki; Shumpei Asamizu; Hiroyasu Onaka; Hideaki Kakeya

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Aug. 2016, Peer-reviewed

  
• Enantioselective Total Synthesis of RQN-18690A (18-Deoxyherboxidiene)

  Yasunobu Matsumoto; Kazuhiro Hibino; Masahiro Yonaga; Hideaki Kakeya; Yujiro Hayashi

  ORGANIC LETTERS, Jul. 2016, Peer-reviewed

  
• Stereochemical Assignment and Biological Evaluation of BE-14106 Unveils the Importance of One Acetate Unit for the Antifungal Activity of Polyene Macrolactams

  Kohei Fujita; Ryosuke Sugiyama; Shinichi Nishimura; Naoki Ishikawa; Midori A. Arai; Masami Ishibashi; Hideaki Kakeya

  JOURNAL OF NATURAL PRODUCTS, Jul. 2016, Peer-reviewed

  
• Isolation and Structure Elucidation of Cytotoxic Saccharothriolides D to F from a Rare Actinomycete Saccharothrix sp and Their Structure-Activity Relationship

  Shan Lu; Shinichi Nishimura; Masashi Ito; Toshio Tsuchida; Hideaki Kakeya

  JOURNAL OF NATURAL PRODUCTS, Jul. 2016, Peer-reviewed

  
• Asymmetric Total Synthesis of Heronamides A-C: Stereochemical Confirmation and Impact of Long-Range Stereochemical Communication on the Biological Activity

  Naoki Kanoh; Shunya Itoh; Kohei Fujita; Kohei Sakanishi; Ryosuke Sugiyama; Yuta Terajima; Yoshiharu Iwabuchi; Shinichi Nishimura; Hideaki Kakeya

  CHEMISTRY-A EUROPEAN JOURNAL, Jun. 2016, Peer-reviewed

  
• Marine sponge cyclic peptide theonellamide A disrupts lipid bilayer integrity without forming distinct membrane pores

  Rafael Atillo Espiritu; Kimberly Cornelio; Masanao Kinoshita; Nobuaki Matsumori; Michio Murata; Shinichi Nishimura; Hideaki Kakeya; Minoru Yoshida; Shigeki Matsunaga

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Jun. 2016, Peer-reviewed

  
• RQN-18690A (18-deoxyherboxidiene) targets SF3b, a spliceosome component, and inhibits angiogenesis

  Hideaki Kakeya; Daisuke Kaida; Hiromi Sekiya; Koji Nagai; Minoru Yoshida; Hiroyuki Osada

  JOURNAL OF ANTIBIOTICS, Feb. 2016, Peer-reviewed

  
• Highly absorptive curcumin reduces serum atherosclerotic low-density lipoprotein levels in patients with mild COPD

  Masafumi Funamoto; Yoichi Sunagawa; Yasufumi Katanasaka; Yusuke Miyazaki; Atsushi Imaizumi; Hideaki Kakeya; Hajime Yamakage; Noriko Satoh-Asahara; Maki Komiyama; Hiromichi Wada; Koji Hasegawa; Tatsuya Morimoto

  INTERNATIONAL JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE, 2016, Peer-reviewed

  
• 非リボソーム性ペプチド合成酵素の選択的ラベル化技術の開発と迅速機能解析システムの構築

  石川 文洋; 今野 翔; 笠井 昭太; 鈴木 健裕; 堂前 直; 掛谷 秀昭

  第58回天然有機化合物討論会講演要旨集, 2016, Peer-reviewed

  
• Affinity purification method for the identification of nonribosomal peptide biosynthetic enzymes using a synthetic probe for adenylation domains

  Ishikawa F; Kakeya H

  Methods in Molecular Biology, 2016, Peer-reviewed

  
• A chemical proteomic probe for detecting native carrier protein motifs in nonribosomal peptide synthetases

  Shota Kasai; Fumihiro Ishikawa; Takehiro Suzuki; Naoshi Dohmae; Hideaki Kakeya

  CHEMICAL COMMUNICATIONS, 2016, Peer-reviewed

  
• A Competitive Enzyme-Linked Immunosorbent Assay System for Adenylation Domains in Nonribosomal Peptide Synthetases

  Ishikawa, F.; Kakeya, H.

  ChemBioChem, 2016, Peer-reviewed

  
• Natural products-prompted chemical biology: phenotypic screening and a new platform for target identification

  Hideaki Kakeya

  NATURAL PRODUCT REPORTS, 2016, Peer-reviewed

  
• Accurate Detection of Adenylation Domain Functions in Nonribosomal Peptide Synthetases by an Enzyme-linked Immunosorbent Assay System Using Active Site-directed Probes for Adenylation Domains

  Fumihiro Ishikawa; Kengo Miyamoto; Sho Konno; Shota Kasai; Hideaki Kakeya

  ACS CHEMICAL BIOLOGY, Dec. 2015, Peer-reviewed

  
• A Multiple-Labeling Strategy for Nonribosomal Peptide Synthetases Using Active-Site-Directed Proteomic Probes for Adenylation Domains

  Fumihiro Ishikawa; Takehiro Suzuki; Naoshi Dohmae; Hideaki Kakeya

  CHEMBIOCHEM, Dec. 2015, Peer-reviewed

  
• Expression, purification and enzymatic characterization of a recombinant human ubiquitin-specific protease 47

  Jinhua Piao; Aika Tashiro; Minako Nishikawa; Yutaka Aoki; Eiko Moriyoshi; Akira Hattori; Hideaki Kakeyay

  JOURNAL OF BIOCHEMISTRY, Dec. 2015, Peer-reviewed

  
• In Vivo Linking of Membrane Lipids and the Anion Transporter Band 3 with Thiourea-modified Amphiphilic Lipid Probes

  Akihiro Moriyama; Naohiro Katagiri; Shinichi Nishimura; Nobuaki Takahashi; Hideaki Kakeya

  SCIENTIFIC REPORTS, Nov. 2015, Peer-reviewed

  
• Structure Elucidation of Verucopeptin, a HIF-1 Inhibitory Polyketide-Hexapeptide Hybrid Metabolite from an Actinomycete

  Aya Yoshimura; Shinichi Nishimura; Saori Otsuka; Akira Hattori; Hideaki Kakeya

  ORGANIC LETTERS, Nov. 2015, Peer-reviewed

  
• Total Synthesis and Structure Revision of Mirubactin, and Its Iron Binding Activity

  Shinji Kishimoto; Shinichi Nishimura; Hideaki Kakeya

  CHEMISTRY LETTERS, Oct. 2015, Peer-reviewed

  
• Profiling Nonribosomal Peptide Synthetase Activities Using Chemical Proteomic Probes for Adenylation Domains

  Fumihiro Ishikawa; Sho Konno; Takehiro Suzuki; Naoshi Dohmae; Hideaki Kakeya

  ACS CHEMICAL BIOLOGY, Sep. 2015, Peer-reviewed

  
• Total Synthesis and Antimicrobial Activity of Chlorocatechelin A

  Shinji Kishilnoto; Shinichi Nishimura; Masaki Hatano; Masayuki Igarashi; Hideaki Kakeya

  JOURNAL OF ORGANIC CHEMISTRY, Jun. 2015, Peer-reviewed

  
• Design, synthesis, and structure-activity relationships of 1-ethylpyrazole-3-carboxamide compounds as novel hypoxia-inducible factor (HIF)-1 inhibitors

  Yorinobu Yasuda; Takeaki Arakawa; Yumi Nawata; Sayaka Shimada; Shinya Oishi; Nobutaka Fujii; Shinichi Nishimura; Akira Hattori; Hideaki Kakeya

  BIOORGANIC & MEDICINAL CHEMISTRY, Apr. 2015, Peer-reviewed

  
• 5-Alkyl-1,2,3,4-tetrahydroquinolines, New Membrane-Interacting Lipophilic Metabolites Produced by Combined Culture of Streptomyces nigrescens and Tsukamurella pulmonis

  Ryosuke Sugiyama; Shinichi Nishimura; Taro Ozaki; Shumpei Asamizu; Hiroyasu Onaka; Hideaki Kakeya

  ORGANIC LETTERS, Apr. 2015, Peer-reviewed

  
• Colloidal Submicron-Particle Curcumin Exhibits High Absorption Efficiency -A Double-Blind, 3-Way Crossover Study-

  Yoichi Sunagawa; Sae Hirano; Yasufumi Katanasaka; Yusuke Miyazaki; Masafumi Funamoto; Nobuko Okamura; Yuya Hojo; Hidetoshi Suzuki; Osamu Doi; Tsunehiro Yokoji; Eriko Morimoto; Tsukasa Takahashi; Hitomi Ozawa; Atsushi Imaizumi; Morio Ueno; Hideaki Kakeya; Akira Shimatsu; Hiromichi Wada; Koji Hasegawa; Tatsuya Morimoto

  JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, Feb. 2015, Peer-reviewed

  
• Functional profiling of adenylation domains in nonribosomal peptide synthetases by competitive activity-based protein profiling

  Shota Kasai; Sho Konno; Fumihiro Ishikawa; Hideaki Kakeya

  CHEMICAL COMMUNICATIONS, 2015, Peer-reviewed

  
• Recent Advances in Adenylation Domain Enzymology in Nonribosomal Peptide Biosynthesis

  Fumihiro Ishikawa; Hideaki Kakeya

  CURRENT ORGANIC CHEMISTRY, 2015, Peer-reviewed, Invited

  
• 使える最新ケミカルバイオロジー A.細胞を操作する化合物 創薬ケミカルバイオロジー シード分子開発と分子プロファイリング

  KAKEYA HIDEAKI

  生体の科学, 2015

  
• 標的同定とバリデーションの実際 生体膜微小環境への挑戦:膜ステロールに作用する海洋天然物セオネラミド

  NISHIMURA SHIN'ICHI; KAKEYA HIDEAKI

  CSJ Curr Rev, 2015

  
• Isolation, Structure Elucidation, and Total Synthesis of Tryptopeptins A and B, New TGF-beta Signaling Modulators from Streptomyces sp.

  Yuta Tsunematsu; Shinichi Nishimura; Akira Hattori; Shinya Oishi; Nobutaka Fujii; Hideaki Kakeya

  ORGANIC LETTERS, Jan. 2015, Peer-reviewed

  
• Active site-directed proteomic probes for adenylation domains in nonribosomal peptide synthetases

  Sho Konno; Fumihiro Ishikawa; Takehiro Suzuki; Naoshi Dohmae; Michael D. Burkart; Hideaki Kakeya

  CHEMICAL COMMUNICATIONS, 2015, Peer-reviewed

  
• UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1 alpha

  Yoko Goto; Lihua Zeng; Chan Joo Yeom; Yuxi Zhu; Akiyo Morinibu; Kazumi Shinomiya; Minoru Kobayashi; Kiichi Hirota; Satoshi Itasaka; Michio Yoshimura; Keiji Tanimoto; Masae Torii; Terumasa Sowa; Toshi Menju; Makoto Sonobe; Hideaki Kakeya; Masakazu Toi; Hiroshi Date; Ester M. Hammond; Masahiro Hiraoka; Hiroshi Harada

  Nature Communications, Jan. 2015, Peer-reviewed

  
• Saccharothriolides A-C, novel phenyl-substituted 10-membered macrolides isolated from a rare actinomycete Saccharothrix sp.

  Shan Lu; Shinichi Nishimura; Go Hirai; Masashi Ito; Teppei Kawahara; Miho Izumikawa; Mikiko Sodeoka; Kazuo Shin-Ya; Toshio Tsuchida; Hideaki Kakeya

  CHEMICAL COMMUNICATIONS, 2015, Peer-reviewed

  
• Chlorocatechelins A and B from Streptomyces sp.: New Siderophores Containing Chlorinated Catecholate Groups and an Acylguanidine Structure

  Shinji Kishimoto; Shinichi Nishimura; Akira Hattori; Masafumi Tsujimoto; Masaki Hatano; Masayuki Igarashi; Hideaki Kakeya

  ORGANIC LETTERS, Dec. 2014, Peer-reviewed

  
• Optimal Dose-Setting Study of Curcumin for Improvement of Left Ventricular Systolic Function After Myocardial Infarction in Rats

  Yoichi Sunagawa; Shogo Sono; Yasufumi Katanasaka; Masafumi Funamoto; Sae Hirano; Yusuke Miyazaki; Yuya Hojo; Hidetoshi Suzuki; Eriko Morimoto; Akira Marui; Ryuzo Sakata; Morio Ueno; Hideaki Kakeya; Hiromichi Wada; Koji Hasegawa; Tatsuya Morimoto

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Dec. 2014, Peer-reviewed

  
• Biosynthetic Origins of the Epoxyquinone Skeleton in Epoxyquinols A and B

  Katsuki Fujita; Fumihiro Ishikawa; Hideaki Kakeya

  JOURNAL OF NATURAL PRODUCTS, Dec. 2014, Peer-reviewed

  
• Balance between Exocytosis and Endocytosis Determines the Efficacy of Sterol-Targeting Antibiotics

  Shinichi Nishimura; Masato Tokukura; Junko Ochi; Minoru Yoshida; Hideaki Kakeya

  CHEMISTRY & BIOLOGY, Dec. 2014, Peer-reviewed

  
• Prediction and Determination of the Stereochemistry of the 1,3,5-Trimethyl-Substituted Alkyl Chain in Verucopeptin, a Microbial Metabolite

  Aya Yoshimura; Shinji Kishimoto; Shinichi Nishimura; Saori Otsuka; Yuki Sakai; Akira Hattori; Hideaki Kakeya

  JOURNAL OF ORGANIC CHEMISTRY, Aug. 2014, Peer-reviewed

  
• A 7-dimethylallyl tryptophan synthase from a fungal Neosartorya sp.: Biochemical characterization and structural insight into the regioselective prenylation

  Kengo Miyamoto; Fumihiro Ishikawa; Shinya Nakamura; Yutaka Hayashi; Isao Nakanishi; Hideaki Kakeya

  BIOORGANIC & MEDICINAL CHEMISTRY, Apr. 2014, Peer-reviewed

  
• Structure and Biological Activity of 8-Deoxyheronamide C from a Marine-Derived Streptomyces sp.: Heronamides Target Saturated Hydrocarbon Chains in Lipid Membranes

  Ryosuke Sugiyama; Shinichi Nishimura; Nobuaki Matsumori; Yuta Tsunematsu; Akira Hattori; Hideaki Kakeya

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2014, Peer-reviewed

  
• Total Synthesis of the Proposed Structure of Heronamide C

  Kohei Sakanishi; Shunya Itoh; Ryosuke Sugiyama; Shinichi Nishimura; Hideaki Kakeya; Yoshiharu Iwabuchi; Naoki Kanoh

  EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Mar. 2014, Peer-reviewed

  
• Specific enrichment of nonribosomal peptide synthetase module by an affinity probe for adenylation domains

  Fumihiro Ishikawa; Hideaki Kakeya

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Feb. 2014, Peer-reviewed

  
• 次世代生命基盤技術を用いたB型肝炎制圧のための創薬研究 スクリーニングに関する研究 HBV候補薬のスクリーニング系開発とスクリーニングに関する研究

  KOJIMA SOICHI; KAKEYA HIDEAKI; SUDO MASAYUKI; YOSHIMOTO TAKAYUKI; SAITO TAMIO; USUI KENGO; YAMAGUCHI TOKIO; FURUTANI YUTAKA; NAKAMURA AKIKO; INOUE IKUYO; SHIMADA SAYAKA; YUKI MIZUE; YAMAMOTO YUKA; SHIN KAN'YO; TSUKUDA SENKO; SAKATA KOTARO

  次世代生命基盤技術を用いたB型肝炎制圧のための創薬研究 平成25年度総括・分担研究報告書, 2014

  
• がんの新規治療を目指した基礎研究 新しいがん薬物療法への革新技術 分子シャペロンHsp90を標的とする抗がん薬創薬

  KAKEYA HIDEAKI

  日本臨床, 2014

  
• Visualization of Sterol-Rich Membrane Domains with Fluorescently-Labeled Theonellamides

  Shinichi Nishimura; Kumiko Ishii; Kunihiko Iwamoto; Yuko Arita; Shigeki Matsunaga; Yoshiko Ohno-Iwashita; Satoshi B. Sato; Hideaki Kakeya; Toshihide Kobayashi; Minoru Yoshida

  PLOS ONE, Dec. 2013, Peer-reviewed

  
• XRNA-methylation-dependent RNA processing controls the speed of the circadian clock

  Jean-Michel Fustin; Masao Doi; Yoshiaki Yamaguchi; Hayashi Hida; Shinichi Nishimura; Minoru Yoshida; Takayuki Isagawa; Masaki Suimye Morioka; Hideaki Kakeya; Ichiro Manabe; Hitoshi Okamura

  Cell, 07 Nov. 2013, Peer-reviewed

  
• Drinkable Preparation of Theracurmin Exhibits High Absorption Efficiency-A Single-Dose, Double-Blind, 4-Way Crossover Study

  Tatsuya Morimoto; Yoichi Sunagawa; Yasufumi Katanasaka; Sae Hirano; Masatoshi Namiki; Yuichi Watanabe; Hidetoshi Suzuki; Osamu Doi; Kiyomi Suzuki; Miyuki Yamauchi; Tsunehiro Yokoji; Eriko Miyoshi-Morimoto; Yoshihiko Otsuka; Tomoko Hamada; Atsushi Imaizumi; Yuji Nonaka; Takashi Fuwa; Takanori Teramoto; Hideaki Kakeya; Hiromichi Wada; Koji Hasegawa

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Nov. 2013, Peer-reviewed

  
• Association of epigenetic alterations in the human C7orf24 gene with the aberrant gene expression in malignant cells

  Yuji Ohno; Akira Hattori; Tatsuhiro Yoshiki; Hideaki Kakeya

  JOURNAL OF BIOCHEMISTRY, Oct. 2013, Peer-reviewed

  
• Interaction between the marine sponge cyclic peptide theonellamide a and sterols in lipid bilayers as viewed by surface plasmon resonance and solid-state 2H nuclear magnetic resonance

  Rafael Atillo Espiritu; Nobuaki Matsumori; Michio Murata; Shinichi Nishimura; Hideaki Kakeya; Shigeki Matsunaga; Minoru Yoshida

  Biochemistry, 09 Apr. 2013, Peer-reviewed

  
• PH-sensitive DNA cleaving agents: In situ activation by ring contraction of benzo-fused cyclobutanols

  Yuuki Nagamoto; Akira Hattori; Hideaki Kakeya; Yoshiji Takemoto; Kiyosei Takasu

  Chemical Communications, 04 Apr. 2013, Peer-reviewed

  
• [The 15th result of screening for antineoplastic agents].

  T. Yamori; Y. Uehara; H. Fukazawa; M. Yoshida; M. Imoto; H. Kiyomiya; T. Mashima; T. Manakami; M. Kawata; H. Nagata; S. Dan; M. Matsuura; H. Kakeya; A. Tomita

  Gan to kagaku ryoho. Cancer & chemotherapy, Apr. 2013, Peer-reviewed

  
• Stereochemical reassignment of heronamide A, a polyketide macrolactam from Streptomyces sp.

  Ryosuke Sugiyama; Shinichi Nishimura; Hideaki Kakeya

  Tetrahedron Letters, 20 Mar. 2013, Peer-reviewed

  
• Chemical tagging of a drug target using 5-sulfonyl tetrazole

  Satsuki Otsuki; Shinichi Nishimura; Hisae Takabatake; Kozue Nakajima; Yasuaki Takasu; Toru Yagura; Yuki Sakai; Akira Hattori; Hideaki Kakeya

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Mar. 2013, Peer-reviewed

  
• 新規分子標的評価を指向した論理的薬剤創製研究

  KAKEYA HIDEAKI

  医科学応用研究財団研究報告(CD-ROM), 2013

  
• 化学療法基盤支援活動報告(2010~2014年度)―制がん候補物質のスクリーニング成績・第15報―

  YAMORI TAKAO; UEHARA YOSHIMASA; FUKAZAWA SHUHO; YOSHIDA MINORU; IMOTO MASAYA; SEIMIYA HIROYUKI; MASHIMA TETSUO; MIZUKAMI TAMIO; KAWADA MANABU; OSADA HIROYUKI; DAN SHINGO; MATSUURA MASAAKI; KAKEYA HIDEAKI; TOMIDA AKIHIRO

  癌と化学療法, 2013

  
• 熱ショック蛋白質阻害剤の現状と可能性

  KASAI SHOTA; NISHIMURA SHIN'ICHI; KAKEYA HIDEAKI

  がん分子標的治療, 2013

  
• [C7orf24/gamma-glutamyl cyclotransferase as a molecular target for cancer chemotherapy].

  Y. Ohno; A. Hattori; H. Kakeya

  Nihon rinsho. Japanese journal of clinical medicine, Nov. 2012, Peer-reviewed

  
• Tumescenamide C, an antimicrobial cyclic lipodepsipeptide from Streptomyces sp.

  Shinji Kishimoto; Yuta Tsunematsu; Shinichi Nishimura; Yutaka Hayashi; Akira Hattori; Hideaki Kakeya

  TETRAHEDRON, Jul. 2012, Peer-reviewed

  
• A Novel Drug Delivery System of Oral Curcumin Markedly Improves Efficacy of Treatment for Heart Failure after Myocardial Infarction in Rats

  Yoichi Sunagawa; Hiromichi Wada; Hidetoshi Suzuki; Hiroki Sasaki; Atsushi Imaizumi; Hiroyuki Fukuda; Tadashi Hashimoto; Yasufumi Katanasaka; Akira Shimatsu; Takeshi Kimura; Hideaki Kakeya; Masatoshi Fujita; Koji Hasegawa; Tatsuya Morimoto

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Feb. 2012, Peer-reviewed

  
• ナノバイオ技術と最新創薬応用研究 第2章 ナノバイオ創薬におけるシード・リード化合物の創出と展開 2.新規創薬リード化合物創製を指向した生合成遺伝子クラスター解析研究

  HAYASHI YUTAKA; NAKAMURA TAKURO; SUGIMOTO HIROYASU; KAKEYA HIDEAKI

  遺伝子医学MOOK, 2012

  
• 天然物創薬とケモインフォマティクス

  ISHIKAWA FUMIHIRO; ARAKI MICHIHIRO; KAKEYA HIDEAKI

  ファルマシア, 2012

  
• がん分子標的としてのC7orf24/γ‐グルタミルシクロトランスフェラーゼ

  ONO YUJI; HATTORI AKIRA; KAKEYA HIDEAKI

  日本臨床, 2012

  
• Clinical application of "curcumin", a multi-functional substance.

  Shimatsu, A

  Anti-Aging Med. (in press), 2012, Peer-reviewed

  
• Multiple NF-Y-binding CCAAT boxes are essential for transcriptional regulation of the human C7orf24 gene, a novel tumor-associated gene

  Yuji Ohno; Akira Hattori; Masamichi Ueda; Susumu Kageyama; Tatsuhiro Yoshiki; Hideaki Kakeya

  FEBS JOURNAL, Nov. 2011, Peer-reviewed

  
• P-43 Pentadepsin A, a Novel Lipodepsipeptide Produced by Streptomyces sp.(Poster Presentation)

  Kishimoto Shinji; Tsunematsu Yuta; Nishimura Shinichi; Hattori Akira; Kakeya Hideaki

  Symposium on the Chemistry of Natural Products, symposium papers, 02 Sep. 2011

  
• A Natural p300-Specific Histone Acetyltransferase Inhibitor, Curcumin, in Addition to Angiotensin-Converting Enzyme Inhibitor, Exerts Beneficial Effects on Left Ventricular Systolic Function After Myocardial Infarction in Rats

  Yoichi Sunagawa; Tatsuya Morimoto; Hiromichi Wada; Tomohide Takaya; Yasufumi Katanasaka; Teruhisa Kawamura; Shigeki Yanagi; Akira Marui; Ryuzo Sakata; Akira Shimatsu; Takeshi Kimura; Hideaki Kakeya; Masatoshi Fujita; Koji Hasegawa

  CIRCULATION JOURNAL, Sep. 2011, Peer-reviewed

  
• Innovative Preparation of Curcumin for Improved Oral Bioavailability

  Hiroki Sasaki; Yoichi Sunagawa; Kenji Takahashi; Atsushi Imaizumi; Hiroyuki Fukuda; Tadashi Hashimoto; Hiromichi Wada; Yasufumi Katanasaka; Hideaki Kakeya; Masatoshi Fujita; Koji Hasegawa; Tatsuya Morimoto

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, May 2011, Peer-reviewed

  
• 細胞膜を撹乱する海洋天然物 セオネラミドはステロールに結合し,異常な細胞壁合成を誘導する

  NISHIMURA SHIN'ICHI; KAKEYA HIDEAKI; YOSHIDA MINORU

  化学と生物, 2011

  
• 心筋細胞核内情報伝達経路を標的とした新規心不全治療法の確立

  MORIMOTO TATSUYA; KITA TOORU; FUJITA MASATOSHI; KAKEYA HIDEAKI; HASEGAWA KOJI

  臨床薬理の進歩, 2011

  
• GBF1-Arf-COPI-ArfGAP-mediated Golgi-to-ER Transport Involved in Regulation of Lipid Homeostasis

  Kouhei Takashima; Akina Saitoh; Shohei Hirose; Waka Nakai; Yumika Kondo; Yasuaki Takasu; Hideaki Kakeya; Hye-Won Shin; Kazuhisa Nakayama

  CELL STRUCTURE AND FUNCTION, 2011, Peer-reviewed

  
• Inhibition of translation by cytotrienin A-a member of the ansamycin family

  Lisa Lindqvist; Francis Robert; William Merrick; Hideaki Kakeya; Christopher Fraser; Hiroyuki Osada; Jerry Pelletier

  RNA-A PUBLICATION OF THE RNA SOCIETY, Dec. 2010, Peer-reviewed

  
• Marine antifungal theonellamides target 3 beta-hydroxysterol to activate Rho1 signaling

  Shinichi Nishimura; Yuko Arita; Miyuki Honda; Kunihiko Iwamoto; Akihisa Matsuyama; Atsuko Shirai; Hisashi Kawasaki; Hideaki Kakeya; Toshihide Kobayashi; Shigeki Matsunaga; Minoru Yoshida

  NATURE CHEMICAL BIOLOGY, Jul. 2010, Peer-reviewed

  
• Novel Natural Products Open the Door of Chemical Biology and Medicinal Chemistry

  掛谷秀昭; 西村慎一

  有機合成化学協会誌, 2010, Peer-reviewed

  
• Total synthesis and determination of the absolute configuration of FD-838, a naturally occurring azaspirobicyclic product

  Yujiro Hayashi; Kuppusamy Sankar; Hayato Ishikawa; Yuriko Nozawa; Kazutoshi Mizoue; Hideaki Kakeya

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jul. 2009, Peer-reviewed

  
• Identification of Cytochrome P450s Required for Fumitremorgin Biosynthesis in Aspergillus fumigatus

  Naoki Kato; Hirokazu Suzuki; Hiroshi Takagi; Yukihiro Asami; Hideaki Kakeya; Masakazu Uramoto; Takeo Usui; Shunji Takahashi; Yoshikazu Sugimoto; Hiroyuki Osada

  CHEMBIOCHEM, Mar. 2009, Peer-reviewed

  
• 政策的に対応を要する疾患等の予防診断・治療法等の開発に関する研究 内因性幹細胞の動員・生着・分化と心筋細胞肥大の情報伝達を標的とした新規心不全治療法

  HASEGAWA KOJI; FUKUDA HIROYUKI; FUJITA MASATOSHI; IKEDA TADASHI; KAKEYA HIDEAKI

  政策創薬総合研究研究報告書 平成20年度, 2009

  
• Azaspirene, a fungal product, inhibits angiogenesis by blocking Raf-1 activation

  Yukihiro Asami; Hideaki Kakeya; Yusuke Komi; Soichi Kojima; Kiyohiro Nishikawa; Kristin Beebe; Len Neckers; Hiroyuki Osada

  CANCER SCIENCE, Sep. 2008, Peer-reviewed

  
• Epoxyquinol B, a naturally occurring pentaketide dimer, inhibits NF-kappa B signaling by crosslinking TAK1

  Hiroshi Kamiyama; Takeo Usui; Hiroaki Sakurai; Mitsuru Shoji; Yujiro Hayashi; Hideaki Kakeya; Hiroyuki Osada

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jul. 2008, Peer-reviewed

  
• Synthesis and structure-activity relationship studies on tryprostatin A, an inhibitor of breast cancer resistance protein

  Hiteshkumar D. Jain; Chunchun Zhang; Shuo Zhou; Hao Zhou; Jun Ma; Xiaoxiang Liu; Xuebin Liao; Amy M. Deveau; Christine M. Dieckhaus; Michael A. Johnson; Kirsten S. Smith; Timothy L. Macdonald; Hideaki Kakeya; Hiroyuki Osada; James M. Cook

  BIOORGANIC & MEDICINAL CHEMISTRY, Apr. 2008, Peer-reviewed

  
• Fungal metabolite, epoxyquinol B, crosslinks proteins by epoxy-thiol conjugation

  Hiroshi Kamiyama; Takeo Usui; Masakazu Uramoto; Hiroshi Takagi; Mitsuru Shoji; Yujiro Hayashi; Hideaki Kakeya; Hiroyuki Osada

  JOURNAL OF ANTIBIOTICS, Feb. 2008, Peer-reviewed

  
• ケミカルバイオロジー研究による新たな創薬標的の提示

  KAKEYA HIDEAKI

  化学, 2008

  
• Epoxyquinol B shows antiangiogenic and antitumor effects by inhibiting VEGFR2, EGFR, FGFR, and PDGFR

  Hiroshi Kamiyama; Hideaki Kakeya; Takeo Usui; Kiyohiro Nishikawa; Mitsuru Shoji; Yujiro Hayashi; Hiroyuki Osada

  ONCOLOGY RESEARCH, 2008, Peer-reviewed

  
• The asymmetric total synthesis of (+)-cytotrienin A, an ansamycin-type anticancer drug

  Yujiro Hayashi; Mitsuru Shoji; Hayato Ishikawa; Junichiro Yamaguchi; Tomohiro Tamura; Hiroki Imai; Yosuke Nishigaya; Kenichi Takabe; Hideaki Kakeya; Hiroyuki Osada

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2008, Peer-reviewed

  
• Small molecules library from microbial metabolites: screening and chemical biology

  掛谷 秀昭; 齊藤 安貴子; 長田 裕之

  Bio industry, Jul. 2007

  
• 住木・梅澤記念賞受賞講演会記録 2006年度受賞講演 微生物が生産する新規生理活性物質の開拓とケミカルバイオロジー研究

  掛谷 秀昭

  The Japanese journal of antibiotics, Jun. 2007, Peer-reviewed

  
• 新しい薬物療法の導入とその最適化に関する研究 抗がん剤の分子標的評価と最適化研究

  KAKEYA HIDEAKI

  新しい薬物療法の導入とその最適化に関する研究 平成18年度 総括・分担研究報告書, 2007

  
• 微生物が生産する新規生理活性物質の開拓とケミカルバイオロジー研究

  KAKEYA HIDEAKI

  Jpn J Antibiot, 2007

  
• 微生物の復権:小分子の宝庫 微生物代謝産物由来の小分子ライブラリーの利用技術―スクリーニングとケミカルバイオロジー研究―

  KAKEYA HIDEAKI; SAITO AKIKO; OSADA HIROYUKI

  Bio Ind, 2007

  
• Discovery of novel bioactive small molecules from microbial metabolites and chemical biology research

  H. Kakeya

  The Japanese journal of antibiotics, 2007, Peer-reviewed

  
• Enantio- and diastereoselective total synthesis of (+)-panepophenanthrin, a ubiquitin-activating enzyme inhibitor, and biological properties of its new derivatives

  Masayoshi Matsuzawa; Hideaki Kakeya; Junichiro Yamaguchi; Mitsuru Shoji; Rie Onose; Hiroyuki Osada; Yujiro Hayashi

  CHEMISTRY-AN ASIAN JOURNAL, Dec. 2006, Peer-reviewed

  
• RK-95113, a new angiogenesis inhibitor produced by Aspergillus fumigatus

  Yukihiro Asami; Hideaki Kakeya; Gen Okada; Masakazu Toi; Hiroyuki Osada

  JOURNAL OF ANTIBIOTICS, Nov. 2006, Peer-reviewed

  
• A bridge between chemistry and biology

  Kazuya Kikuchi; Hideaki Kakeya

  NATURE CHEMICAL BIOLOGY, Aug. 2006, Peer-reviewed

  
• Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity

  N Watanabe; Y Nishihara; T Yamaguchi; A Koito; H Miyoshi; H Kakeya; H Osada

  FEBS LETTERS, May 2006, Peer-reviewed

  
• Computational study on the reaction mechanism of the key thermal [4+4] cycloaddition reaction in the biosynthesis of epoxytwinol A

  Shiina, I; T Uchimaru; M Shoji; H Kakeya; H Osada; Y Hayashi

  ORGANIC LETTERS, Mar. 2006, Peer-reviewed

  
• Implementation of new drug therapies and optimization. Evaluation of target molecules for anti-cancer drugs and therapy optimization.

  掛谷秀昭

  新しい薬物療法の導入とその最適化に関する研究 平成17年度 総括・分担研究報告書, 2006

  
• [Special Issue: Fact Databases and Freewares] RIKEN Natural Products Encyclopedia (RIKEN NPEdia),a Chemical Database of RIKEN Natural Products Depository (RIKEN NPDepo)

  富木 毅; 富木 毅; 斎藤 臣雄; 植木 雅志; 今野 英明; 浅岡 丈生; 鈴木 龍一郎; 浦本 昌和; 掛谷秀昭; 長田 裕之

  Journal of Computer Aided Chemistry (Web), 2006

  
• 固形がん分子標的治療の新しい展開 固形がんの征圧を目指した抗がん剤の開発

  OSADA HIROYUKI; KAKEYA HIDEAKI

  がん分子標的治療, 2006

  
• Synthesis and biological properties of new phosmidosine analogs having an N-acylsulfamate linkage

  Haruhiko Taguchi; Akihiro Ohkubo; Mitsuo Sekine; Kohji Seio; Hideaki Kakeya; Hiroyuki Osada; Takuma Sasaki

  NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 2006, Peer-reviewed

  
• Concise enantio- and diastereoselective total syntheses of fumagillol, RK-805, FR65814, ovalicin, and 5-demethylovalicin

  J Yamaguchi; M Toyoshima; M Shoji; H Kakeya; H Osada; Y Hayashi

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, Peer-reviewed

  
• Enantio- and diastereoselective total synthesis of EI-1941-1, -2, and -3, inhibitors of interleukin-1 beta converting enzyme, and biological properties of their derivatives

  M Shoji; T Uno; H Kakeya; R Onose; Shiina, I; H Osada; Y Hayashi

  JOURNAL OF ORGANIC CHEMISTRY, Nov. 2005, Peer-reviewed

  
• RKTS-33, an epoxycyclohexenone derivative that specifically inhibits Fas ligand-dependent apoptosis in CTL-mediated cytotoxicity

  T Mitsui; Y Miyake; H Kakeya; Y Hayashi; H Osada; T Kataoka

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Oct. 2005, Peer-reviewed

  
• 新しい血管新生阻害剤におけるケミカルゲノミクス (特集 ケミカルゲノミクスの誕生)

  Kwon Ho Jeong; 掛谷 秀昭

  蛋白質核酸酵素, Aug. 2005

  
• First asymmetric total synthesis of synerazol, an antifungal antibiotic, and determination of its absolute stereochemistry

  Y Hayashi; M Shoji; T Mukaiyama; H Gotoh; S Yamaguchi; M Nakata; H Kakeya; H Osada

  JOURNAL OF ORGANIC CHEMISTRY, Jul. 2005, Peer-reviewed

  
• Epolactaene binds human Hsp60 Cys(442) resulting in the inhibition of chaperone activity

  Y Nagumo; H Kakeya; M Shoji; Y Hayashi; N Dohmae; H Osada

  BIOCHEMICAL JOURNAL, May 2005, Peer-reviewed

  
• Implementation of new drug therapies and optimization. Evaluation of target molecules for anti-cancer drugs and therapy optimization.

  掛谷秀昭

  新しい薬物療法の導入とその最適化に関する研究 平成16年度 総括・分担研究報告書, 2005

  
• Chemical genomics on new angiogenesis inhibitors

  H.J. Kwon; H. Kakeya

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 2005, Peer-reviewed

  
• Determination by asymmetric total synthesis of the absolute configuration of lucilactaene, a cell-cycle inhibitor in p53-transfected cancer cells

  J Yamaguchi; H Kakeya; T Uno; M Shoji; H Osada; Y Hayashi

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2005, Peer-reviewed

  
• Total synthesis of epoxyquinols A, B, and C and epoxytwinol A and the reactivity of a 2H-Pyran derivative as the diene component in the Diels-Alder reaction

  M Shoji; H Imai; M Mukaida; K Sakai; H Kakeya; H Osada; Y Hayashi

  JOURNAL OF ORGANIC CHEMISTRY, Jan. 2005, Peer-reviewed

  
• Epoxytwinol A, a novel unique angiogenesis inhibitor with C-2 symmetry, produced by a fungus

  H Kakeya; R Onose; H Koshino; H Osada

  CHEMICAL COMMUNICATIONS, 2005, Peer-reviewed

  
• Synthesis of a biotin-conjugate of phosmidosine O-ethyl ester as a G1 arrest antitumor drug

  M Sekine; K Okada; K Seio; T Obata; T Sasaki; H Kakeya; H Osada

  BIOORGANIC & MEDICINAL CHEMISTRY, Dec. 2004, Peer-reviewed

  
• Structure-activity relationship of phosmidosine: importance of the 7,8-dihydro-8-oxoadenosine residue for antitumor activity

  M Sekine; K Okada; K Seio; H Kakeya; H Osada; T Sasaki

  BIOORGANIC & MEDICINAL CHEMISTRY, Oct. 2004, Peer-reviewed

  
• Structure-activity relationships of epolactaene derivatives: structural requirements for inhibition of Hsp60 chaperone activity

  Y Nagumo; H Kakeya; J Yamaguchi; T Uno; M Shoji; Y Hayashi; H Osada

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Sep. 2004, Peer-reviewed

  
• RK-805, an endothelial-cell-growth inhibitor produced by Neosartorya sp., and a docking model with methionine aminopeptidase-2

  Y Asami; H Kakeya; R Onose; YH Chang; M Toi; H Osada

  TETRAHEDRON, Aug. 2004, Peer-reviewed

  
• ECH, an epoxycyclohexenone derivative that specifically inhibits Fas ligand-dependent apoptosis in CTL-mediated cytotoxicity

  T Mitsui; Y Miyake; H Kakeya; H Osada; T Kataoka

  JOURNAL OF IMMUNOLOGY, Mar. 2004, Peer-reviewed

  
• Different reaction modes for the oxidative dimerization of epoxyquinols and epoxyquinones. Importance of intermolecular hydrogen-bonding

  M Shoji; H Imai; Shiina, I; H Kakeya; H Osada; Y Hayashi

  JOURNAL OF ORGANIC CHEMISTRY, Mar. 2004, Peer-reviewed

  
• 治療薬の探索 血管新生関連 癌分子標的治療のための新しい血管新生阻害剤

  OSADA HIROYUKI; KAKEYA HIDEAKI

  日本臨床, 2004

  
• 治療薬の探索 アポトーシス デスレセプター依存性アポトーシス抑制化合物ECHの作用機序および標的分子

  MIYAKE YASUNOBU; KAKEYA HIDEAKI; OSADA HIROYUKI

  日本臨床, 2004

  
• 治療薬の探索 血管新生関連 血管内皮増殖因子(VEGF)の機能を標的とした新規血管新生阻害剤

  KAKEYA HIDEAKI; OSADA HIROYUKI

  日本臨床, 2004

  
• Mode of action and molecular target of ECH, a specific inhibitor of death receptor-dependent apoptosis

  Y. Miyake; H. Kakeya; H. Osada

  Nippon rinsho. Japanese journal of clinical medicine, 2004, Peer-reviewed

  
• Novel angiogenesis inhibitors for molecular target therapy of cancer

  H. Osada; H. Kakeya

  Nippon rinsho. Japanese journal of clinical medicine, 2004, Peer-reviewed

  
• Epoxycyclohexenone, a specific inhibitor of Fas ligand-dependent apoptosis in CCTL-mediated cytotoxicity

  Mitsui, T

  J. Immunology,172, 3423-3436, 2004, Peer-reviewed

  
• Synthesis of chemically stabilized phosmidosine analogues and the structure-activity relationship of phosmidosine

  M Sekine; K Okada; K Seio; H Kakeya; H Osada; T Obata; T Sasaki

  JOURNAL OF ORGANIC CHEMISTRY, Jan. 2004, Peer-reviewed

  
• Novel non-peptide inhibitors targeting death receptor-mediated apoptosis

  H Kakeya; Y Miyake; M Shoji; S Kishida; Y Hayashi; T Kataoka; H Osada

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Nov. 2003, Peer-reviewed

  
• Synthesis and cell cycle inhibition of the peptide enamide natural products terpeptin and the aspergillamides

  S Su; H Kakeya; H Osada; JA Porco

  TETRAHEDRON, Nov. 2003, Peer-reviewed

  
• Reaction modes of oxidative dimerization of epoxycyclohexenols

  M Shoji; S Kishida; Y Kodera; Shiina, I; H Kakeya; H Osada; Y Hayashi

  TETRAHEDRON LETTERS, Sep. 2003, Peer-reviewed

  
• Asymmetric total synthesis of pseurotin A

  Y Hayashi; M Shoji; S Yamaguchi; T Mukaiyama; J Yamaguchi; H Kakeya; H Osada

  ORGANIC LETTERS, Jun. 2003, Peer-reviewed

  
• Epoxycyclohexenone inhibits Fas-mediated apoptosis by blocking activation of pro-caspase-8 in the death-inducing signaling complex

  Y Miyake; H Kakeya; T Kataoka; H Osada

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2003, Peer-reviewed

  
• Synthesis and biological properties of stable phosmidosine analogs.

  K. Okada; H. Taguchi; K. Seio; H. Kakeya; H. Osada; T. Sasaki; M. Sekine

  Nucleic acids research. Supplement (2001), 2003, Peer-reviewed

  
• Biotransformation of the mycotoxin, zearalenone, to a non-estrogenic compound by a fungal strain of Clonostachys sp.

  H Kakeya; N Takahashi-Ando; M Kimura; R Onose; Yamaguchi, I; H Osada

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Dec. 2002, Peer-reviewed

  
• A practical total synthesis of both enantiomers of epoxyquinols A and B

  M Shoji; S Kishida; M Takeda; H Kakeya; H Osada; Y Hayashi

  TETRAHEDRON LETTERS, Dec. 2002, Peer-reviewed

  
• PC-766B' and PC-766B, 16-membered macrolide angiogenesis inhibitors produced by Nocardia sp RK97-56

  HR Ko; H Kakeya; A Yoshida; R Onose; M Ueki; M Muroi; A Takatsuki; H Matsuzaki; H Osada

  JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, Oct. 2002, Peer-reviewed

  
• Asymmetric total synthesis of (-)-azaspirene, a novel angiogenesis inhibitor

  Y Hayashi; M Shoji; J Yamaguchi; K Sato; S Yamaguchi; T Mukaiyama; K Sakai; Y Asami; H Kakeya; H Osada

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Oct. 2002, Peer-reviewed

  
• Epoxyquinol B, a fungal metabolite with a potent antiangiogenic activity

  H Kakeya; R Onose; A Yoshida; H Koshino; H Osada

  JOURNAL OF ANTIBIOTICS, Sep. 2002, Peer-reviewed

  
• 細胞の生死を制御する天然有機化合物を利用した化学生物学的研究

  KAKEYA HIDEAKI

  日本農芸化学会誌, 01 Aug. 2002

  
• Azaspirene: A novel angiogenesis inhibitor containing a 1-oxa-7-azaspiro[4.4]non-2-ene-4,6-dione skeleton produced by the fungus Neosartotya sp.

  Y Asami; H Kakeya; R Onose; A Yoshida; H Matsuzaki; H Osada

  ORGANIC LETTERS, Aug. 2002, Peer-reviewed

  
• A novel lactonohydrolase responsible for the detoxification of zearalenone: enzyme purification and gene cloning

  N Takahashi-Ando; M Kimura; H Kakeya; H Osada; Yamaguchi, I

  BIOCHEMICAL JOURNAL, Jul. 2002, Peer-reviewed

  
• Epoxyquinol A, a highly functionalized pentaketide dimer with antiangiogenic activity isolated from fungal metabolites

  H Kakeya; R Onose; H Koshino; A Yoshida; K Kobayashi; S Kageyama; H Osada

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2002, Peer-reviewed

  
• 抗感染症薬の標的:ミトコンドリア呼吸鎖 : 複合体I

  掛谷 秀昭

  ファルマシア, 01 Mar. 2002

  
• Fas誘導性アポトーシス阻害物質RK‐302の抑制機構解析

  MIYAKE YASUNOBU; TAKEYA HIDEAKI; KATAOKA TAKAO; NAGATA HIROYUKI

  生化学, 2002

  
• がん征圧と化学 最新抗がん剤事情

  KAKEYA HIDEAKI; OSADA HIROYUKI

  化学と工業, 2002

  
• Chemical and biological studies on novel natural products regulating proliferation, differentiation, and apoptosis in mammalian cells

  H Kakeya

  NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY, 2002, Peer-reviewed

  
• Total synthesis of (+)-epoxyquinols A and B

  M Shoji; J Yamaguchi; H Kakeya; H Osada; Y Hayashi

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2002, Peer-reviewed

  
• A facile and effective screening method for p21(WAF1) promoter activators from microbial metabolites

  L Nie; M Ueki; H Kakeya; H Osada

  JOURNAL OF ANTIBIOTICS, Oct. 2001, Peer-reviewed

  
• Lucilactaene, a new cell cycle inhibitor in p53-transfected cancer cells, produced by a Fusarium sp.

  H Kakeya; S Kageyama; L Nie; R Onose; G Okada; T Beppu; CJ Norbury; H Osada

  JOURNAL OF ANTIBIOTICS, Oct. 2001, Peer-reviewed

  
• ミトコンドリアを標的とした抗がん剤 アポトーシス研究におけるバイオプローブの貢献

  KAKEYA HIDEAKI; MIYAKE YASUNOBU; OSADA HIROYUKI

  化学, 2001

  
• Activation of MST/Krs and c-jun N-terminal kinases by different signaling pathways during cytotrienin A-induced apoptosis

  M Watabe; H Kakeya; R Onose; H Osada

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2000, Peer-reviewed

  
• 細胞の増殖シグナルに及ぼす微小重力の影響

  WATANABE MASAHIKO; ONOSE RIE; IKENO AYUMI; KAKEYA HIDEAKI; OSADA HIROYUKI

  日本マイクログラビティ応用学会誌, 2000

  
• Requirement of protein kinase (Krs/MST) activation for MT-21-induced apoptosis

  M Watabe; H Kakeya; H Osada

  ONCOGENE, Sep. 1999, Peer-reviewed

  
• Cytoxazone: A novel cytokine modulator containing a 2-oxazolidinone ring produced by Streptomyces sp.

  H Kakeya; M Morishita; H Koshino; T Morita; K Kobayashi; H Osada

  JOURNAL OF ORGANIC CHEMISTRY, Feb. 1999, Peer-reviewed

  
• Activation of a 36-kD MBP kinase, an active proteolytic fragment of MST/Krs proteins, during anticancer drug-induced apoptosis

  H Kakeya; R Onose; H Osada

  ANTICANCER MOLECULES: STRUCTURE, FUNCTION, AND DESIGN, 1999, Peer-reviewed

  
• Isolation and biological activity of a novel cytokine modulator, cytoxazone

  H Kakeya; M Morishita; K Kobinata; M Osono; M Ishizuka; H Osada

  JOURNAL OF ANTIBIOTICS, Dec. 1998, Peer-reviewed

  
• Effect of Microgravity on the Expression of Growth-Related Genes in Osteoblasts

  SATO Atsushige; HAMAZAKI Tatsuo; OOMURA Takeo; HONGO Toshio; MASUDA Ichiro; ANDO Jun; NODA Masaki; OSADA Hiroyuki; KAKEYA Hideaki; WATABE Masahiko; TANAKA Hiroaki; TAKAOKI Muneo; KOHNO Yasushi; NAKAMURA Tomihisa; NAKAMURA Yasuhiro; OGISO Akio; KOSHIKAWA Naokiyo; YOSHIZAKI Izumi; AIZAWA Sachiko; YODA Shin-ichi

  宇宙生物科学 = Biological sciences in space, Nov. 1998

  
• Caspase-mediated activation of a 36-kDa myelin basic protein kinase during anticancer drug-induced apoptosis

  H Kakeya; R Onose; H Osada

  CANCER RESEARCH, Nov. 1998, Peer-reviewed

  
• Effect of Microgravity on the Expression of Growth-Related Genes in Osteoblasts

  SATO Atsushige; HAMAZAKI Tatsuo; HONGO Toshio; MASUDA Ichiro; ANDO Jun; NODA Masaki; OOMURA Takeo; OSADA Hiroyuki; KAKEYA Hideaki; WATABE Masahiko; TANAKA Hiroaki; TAKAOKI Muneo; KOHNO Yasushi; NAKAMURA Tomihisa; NAKAMURA Yasuhiro; YOSHIZAKI Izumi; KOSHIKAWA Naokiyo; AIZAWA Sachiko; OGISO Akio; YODA Shin-ichi

  JASMA, 31 Oct. 1998

  
• Factumycin and its new derivative RK-1009 enhance threonine-phosphorylation of a 60-kDa protein in Streptomyces griseus

  H Kakeya; M Morishita; A Ikeno; K Kobinata; T Yano; H Osada

  JOURNAL OF ANTIBIOTICS, Oct. 1998, Peer-reviewed

  
• Biosynthesis of 1-aminocyclopropane-1-carboxylic acid moiety on cytotrienin A in Streptomyces sp.

  HP Zhang; H Kakeya; H Osada

  TETRAHEDRON LETTERS, Sep. 1998, Peer-reviewed

  
• アポト-シス誘導性バイオプロ-ブの探索と作用機構 (特集 バイオプロ-ブ--微生物由来細胞機能調節物質の研究開発動向)

  長田 裕之; 臼井 健郎; 掛谷 秀昭

  バイオインダストリ-, Jul. 1998

  
• Inhibition of cyclin D1 expression and phosphorylation of retinoblastoma protein by phosmidosine, a nucleotide antibiotic

  H Kakeya; R Onose; PCC Liu; C Onozawa; F Matsumura; H Osada

  CANCER RESEARCH, Feb. 1998, Peer-reviewed

  
• Microorganisms producing bioactive substances. 1. Analysis of bioactive low-molecular substances derived from microorganisms and development of quick identification method. (Sci. and Technol. Agency, Res. and Dev. Bur. S).

  長田裕之; 小日向君江; 掛谷秀昭

  アジア地域の微生物研究ネットワークに関する研究(第1期)成果報告書 平成7-9年度, 1998

  
• Apoptosis Inducing Bioprobes. Screening and Mode of Action.

  長田裕之; 臼井健郎; 掛谷秀昭

  Bio Industry, 1998

  
• Inhibition of human telomerase activity by alterperylenol

  K Togashi; H Kakeya; M Morishita; YX Song; H Osada

  ONCOLOGY RESEARCH, 1998, Peer-reviewed

  
• RKS-1778, a new mammalian cell-cycle inhibitor and a key intermediate of the [11]cytochalasin group

  H Kakeya; M Morishita; C Onozawa; R Usami; K Horikoshi; K Kimura; M Yoshihama; H Osada

  JOURNAL OF NATURAL PRODUCTS, Jul. 1997, Peer-reviewed

  
• Exploitation of anticancer compounds from marine microbes

  H Kakeya; H Okada

  NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY, May 1997

  
• Exploitation of anticancer compounds from marine microbes

  H Kakeya; H Okada

  NIPPON NOGEIKAGAKU KAISHI-JOURNAL OF THE JAPAN SOCIETY FOR BIOSCIENCE BIOTECHNOLOGY AND AGROCHEMISTRY, May 1997, Peer-reviewed

  
• Cytotrienin A, a novel apoptosis inducer in human leukemia HL-60 cells

  H Kakeya; HP Zhang; K Kobinata; R Onose; C Onozawa; T Kudo; H Osada

  JOURNAL OF ANTIBIOTICS, Apr. 1997, Peer-reviewed

  
• Novel triene-ansamycins, cytotrienins A and B, inducing apoptosis on human leukemia HL-60 cells

  HP Zhang; H Kakeya; H Osada

  TETRAHEDRON LETTERS, Mar. 1997, Peer-reviewed

  
• Neuritogenic effect of epolactaene derivatives on human neuroblastoma cells which lack high-affinity nerve growth factor receptors

  H Kakeya; C Onozawa; M Sato; K Arai; H Osada

  JOURNAL OF MEDICINAL CHEMISTRY, Feb. 1997, Peer-reviewed

  
• Low-Molecular-Weight Organic Compounds Having Neurotrophic Activity.

  長田裕之; 八尾良司; 掛谷秀昭

  月刊組織培養工学, 1997

  
• First identification of mammal histone deacetylase using a low-moleculer bio probe.

  掛谷秀昭

  化学と工業, 1997

  
• Novel mammalian cell cycle inhibitors, cyclotryprostatins A-D, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M phase

  CB Cui; H Kakeya; H Osada

  TETRAHEDRON, Jan. 1997, Peer-reviewed

  
• Sparoxomycins A1 and A2, new inducers of the flat reversion, of NRK cells transformed by temperature sensitive Rous sarcoma virus .1. Taxonomy of the producing organism, fermentation and biological activity

  M Ubukata; T Morita; H Kakeya; K Kobinata; T Kudo; H Osada

  JOURNAL OF ANTIBIOTICS, Nov. 1996, Peer-reviewed

  
• Novel mammalian cell cycle inhibitors, spirotryprostatins A and B, produced by Aspergillus fumigatus, which inhibit mammalian cell cycle at G2/M phase

  CB Cui; H Kakeya; H Osada

  TETRAHEDRON, Sep. 1996, Peer-reviewed

  
• Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus .1. Taxonomy, fermentation, isolation and biological properties

  CB Cui; H Kakeya; G Okada; R Onose; H Osada

  JOURNAL OF ANTIBIOTICS, Jun. 1996, Peer-reviewed

  
• Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus .2. Physico-chemical properties and structures

  CB Cui; H Kakeya; H Osada

  JOURNAL OF ANTIBIOTICS, Jun. 1996, Peer-reviewed

  
• Acetophthalidin, a novel inhibitor of mammalian cell cycle, produced by a fungus isolated from a sea sediment

  CB Cui; M Ubukata; H Kakeya; R Onose; G Okada; Takahashi, I; K Isono; H Osada

  JOURNAL OF ANTIBIOTICS, Feb. 1996, Peer-reviewed

  
• TRYPROSTATIN-A AND TRYPROSTATIN-B, NOVEL MAMMALIAN-CELL CYCLE INHIBITORS PRODUCED BY ASPERGILLUS-FUMIGATUS

  CB CUI; H KAKEYA; G OKADA; R ONOSE; M UBUKATA; TAKAHASHI, I; K ISONO; H OSADA

  JOURNAL OF ANTIBIOTICS, Nov. 1995, Peer-reviewed

  
• EPOLACTAENE, A NOVEL NEURITOGENIC COMPOUND HUMAN NEUROBLASTOMA-CELLS, PRODUCED BY A MARINE FUNGUS

  H KAKEYA; TAKAHASHI, I; G OKADA; K ISONO; H OSADA

  JOURNAL OF ANTIBIOTICS, Jul. 1995, Peer-reviewed

  
• Microbial products for drug development in the nervous system.

  掛谷秀昭

  バイオサイエンスとインダストリー, 1995

  
• DEPHOSTATIN, A NOVEL PROTEIN-TYROSINE-PHOSPHATASE INHIBITOR PRODUCED BY STREPTOMYCES .1. TAXONOMY, ISOLATION, AND CHARACTERIZATION

  M IMOTO; H KAKEYA; T SAWA; C HAYASHI; M HAMADA; T TAKEUCHI; K UMEZAWA

  JOURNAL OF ANTIBIOTICS, Sep. 1993, Peer-reviewed

  
• ISOLATION OF A NOVEL SUBSTRATE-COMPETITIVE TYROSINE KINASE INHIBITOR, DESMAL, FROM THE PLANT DESMOS-CHINENSIS

  H KAKEYA; M IMOTO; Y TABATA; J IWAMI; H MATSUMOTO; K NAKAMURA; T KOYANO; K TADANO; K UMEZAWA

  FEBS LETTERS, Apr. 1993, Peer-reviewed

  
• Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces: Structure determination

  Hideaki Kakeya; Masaya Imoto; Yoshikazu Takahashil; Hiroshi Naganawa; Tomio Takeuchi; Kazuo Umezawa

  Journal of Antibiotics, 1993

  
• INDUCTION OF MORPHOLOGICAL AND ENZYMATIC DIFFERENTIATION IN RAT PHEOCHROMOCYTOMA PC12H CELLS BY STABLE ERBSTATIN ANALOGS

  Y WATANABE; H KAKEYA; E IKOMA; K UMEZAWA

  DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH, 1993, Peer-reviewed

  
• PREPARATION OF ENANTIOMERICALLY ENRICHED COMPOUNDS BY USING ENZYMES .10. BIOCHEMICAL PREPARATION OF OPTICALLY-ACTIVE 4-HYDROXY-BETA-IONONE AND ITS TRANSFORMATION TO (S)-6-HYDROXY-ALPHA-IONONE

  H KAKEYA; T SUGAI; H OHTA

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY, Jul. 1991, Peer-reviewed

  
• PREPARATION OF ENANTIOMERICALLY ENRICHED COMPOUNDS BY USING ENZYMES .11. PREPARATION OF OPTICALLY-ACTIVE ALPHA-HYDROXY ACID-DERIVATIVES BY MICROBIAL HYDROLYSIS OF CYANOHYDRINS AND ITS APPLICATION TO THE SYNTHESIS OF (R)-4-DODECANOLIDE

  H KAKEYA; N SAKAI; T SUGAI; H OHTA

  AGRICULTURAL AND BIOLOGICAL CHEMISTRY, Jul. 1991, Peer-reviewed

  
• MICROBIAL HYDROLYSIS AS A POTENT METHOD FOR THE PREPARATION OF OPTICALLY-ACTIVE NITRILES, AMIDES AND CARBOXYLIC-ACIDS

  H KAKEYA; N SAKAI; T SUGAI; H OHTA

  TETRAHEDRON LETTERS, Mar. 1991, Peer-reviewed

  
• PREPARATION OF ENANTIOMERICALLY ENRICHED COMPOUNDS USING ENZYMES .3. ENZYMATIC PREPARATION OF ENANTIOMERICALLY ENRICHED TERTIARY ALPHA-BENZYLOXY ACID-ESTERS - APPLICATION TO THE SYNTHESIS OF (S)-(-)-FRONTALIN

  T SUGAI; H KAKEYA; H OHTA

  JOURNAL OF ORGANIC CHEMISTRY, Jul. 1990, Peer-reviewed

  
• STRUCTURE OF (+/-)-2-HYDROXYMETHYL-2,6-DIMETHYLCYCLOHEXAN-1-OL

  M MOROOKA; S OHBA; T SUGAI; H KAKEYA; H OHTA; Y SAITO

  ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, Jan. 1990, Peer-reviewed

  
• PREPARATION OF CHIRAL COMPOUND USING ENZYMES .4. A SYNTHESIS OF (R)-(-)-MEVALONOLACTONE BY THE COMBINATION OF ENZYMATIC AND CHEMICAL METHODS

  T SUGAI; H KAKEYA; H OHTA

  TETRAHEDRON, 1990, Peer-reviewed

  
• PREPARATION OF CHIRAL COMPOUND USING ENZYMES .2. A SYNTHESIS OF (-)-DEOXYPODOCARPIC ACID METHYL-ESTER VIA AN ENZYMATIC ENANTIOSELECTIVE HYDROLYSIS OF THE KEY INTERMEDIATE ENOL ESTER

  T SUGAI; H KAKEYA; H OHTA; M MOROOKA; S OHBA

  TETRAHEDRON, 1989, Peer-reviewed

  

Misc.

• 無作為割付クロスオーバー2重盲検試験によりクルクミン製剤Theracurminは既存のクルクミン製剤よりも優れた経口吸収性を示した

  砂川 陽一; 平野 早絵; 岡村 信子; 刀坂 泰史; 土井 修; 横地 常広; 高橋 司; 今泉 厚; 橋本 正; 掛谷 秀昭; 和田 啓道; 島津 章; 長谷川 浩二; 森本 達也

  日本抗加齢医学会総会プログラム・抄録集, Jun. 2014

  
• 無作為割付クロスオーバー2重盲検試験によってTheracurminは他のクルクミン製剤よりも優れた吸収効率の向上がみられた

  岡村 信子; 砂川 陽一; 刀坂 泰史; 平野 早絵; 並木 雅俊; 渡邉 雄一; 土井 修; 横地 常広; 高橋 司; 松井 崇人; 濱田 友子; 今泉 厚; 橋本 正; 掛谷 秀昭; 和田 啓道; 島津 章; 長谷川 浩二; 森本 達也

  日本薬学会年会要旨集, Mar. 2014

  
• 高吸収性クルクミンであるセラクルミン配合飲料は既存クルクミン飲料よりも高い吸収効率を示した

  砂川 陽一; 刀坂 泰史; 平野 早絵; 並木 雅俊; 渡邊 雄一; 土井 修; 鈴木 清美; 山内 みゆき; 横地 常弘; 大塚 喜彦; 今泉 厚; 橋本 正; 野中 裕二; 不破 喬; 寺本 貴則; 掛谷 秀昭; 和田 啓道; 島津 章; 長谷川 浩二; 森本 達也

  日本抗加齢医学会総会プログラム・抄録集, Jun. 2013

  
• 4製剤無作為割付クロスオーバー2重盲検試験により、セラクルミン配合飲料の高い吸収効率が実証された

  刀坂 泰史; 砂川 陽一; 並木 雅俊; 平野 早絵; 渡邉 雄一; 鈴木 清美; 山内 みゆき; 横地 常広; 濱田 友子; 大塚 喜彦; 今泉 厚; 野中 裕司; 不破 喬; 寺本 貴則; 和田 啓道; 掛谷 秀昭; 土井 修; 長谷川 浩二; 森本 達也

  日本薬学会年会要旨集, Mar. 2013

  
• Natural Products-Based Chemical Biology : 独創的なケミカルバイオロジー研究を目指して

  掛谷 秀昭

  バイオサイエンスとインダストリー = Bioscience & industry, 01 Feb. 2007

  
• 神経細胞分化誘導剤エポラクタエン類縁化合物の生物活性 : 有機化学・天然物化学

  掛谷 秀昭; 小野澤 千津子; 佐藤 正和; 新井 好史; 長田 裕之

  日本農藝化學會誌, 05 Mar. 1996

  
• 神経突起伸張作用を有する新規化合物エポラクタエンの単離精製 : 有機化学・天然物化学

  掛谷 秀昭; 小野瀬 利恵; 小日向 君江; 岡田 元; 高橋 勇; 磯野 清; 長田 裕之

  日本農藝化學會誌, 05 Jul. 1995

  
• 複合培養におけるStreptomyces sp.HEK616による5aTHQの生産機構

  浅水俊平; 尾崎太郎; 尾崎太郎; 西村慎一; 西村慎一; 掛谷秀昭; 尾仲宏康

  日本農芸化学会大会講演要旨集(Web), 2019

  
• Streptomyces sp.HEK616とTsukamurella pulmonisとの複合培養での二次代謝活性化機構の解析

  浅水俊平; 浅水俊平; 尾崎太郎; 西村慎一; 掛谷秀昭; 尾仲宏康; 尾仲宏康

  日本放線菌学会大会講演要旨集, 2019

  
• テトラヒドロキノリン骨格を有する新規放線菌代謝物の構造多様性と生物活性

  杉山龍介; 西村慎一; 尾崎太郎; 尾仲宏康; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2014

  
• Total Synthesis of Cryptopleurine Derivatives and their Bioactivity Evaluation

  山岡庸介; 立石海斗; 山川拓朗; 服部明; 瀧川紘; 掛谷秀昭; 高須清誠

  日本薬学会年会要旨集(Web), 2021

  
• Membrane Affinity and Biological Activities of 5aTHQs, Combined-culture Metabolites

  西村慎一; 西村慎一; 杉山龍介; 仲谷崇宏; 尾崎太郎; 浅水俊平; 尾仲宏康; 掛谷秀昭

  天然有機化合物討論会講演要旨集(Web), 2018

  
• 複合培養によって生産されるテトラヒドロキノリン化合物の解析

  下村杜人; 尾崎太郎; 杉山龍介; 西村慎一; 浅水俊平; 掛谷秀昭; 尾仲宏康

  日本放線菌学会大会講演要旨集, 2017

  
• 複合培養特異的に生産されるテトラヒドロキノリン生合成遺伝子の解析

  下村杜人; 尾崎太郎; 杉山龍介; 西村慎一; 浅水俊平; 掛谷秀昭; 尾仲宏康

  日本農芸化学会大会講演要旨集(Web), 2016

  
• 脂質結合性天然物の活用-放線菌複合培養液より見出した新規アルカロイド群に関する研究

  杉山龍介; 西村慎一; 尾崎太郎; 浅水俊平; 尾仲宏康; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2016

  
• 微生物の複合培養で得られる5aTHQとstreptoaminalの構造と機能

  西村慎一; 杉山龍介; 仲谷崇宏; 尾崎太郎; 浅水俊平; 尾仲宏康; 掛谷秀昭

  天然薬物の開発と応用シンポジウム講演要旨集, 2016

  
• Heronamide AおよびBの生成機構に関する研究

  藤田航平; 杉山龍介; 西村慎一; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2015

  
• 複合培養を利用した新規テトラヒドロキノリン類の単離とその生合成に関する研究

  尾崎太郎; 杉山龍介; 西村慎一; 浅水俊平; 掛谷秀昭; 尾仲宏康

  日本放線菌学会大会講演要旨集, 2014

  
• 放線菌の複合培養法による新規テトラヒドロキノリン類の単離とその生合成

  尾崎太郎; 森夕希子; 杉山龍介; 西村慎一; 浅水俊平; 掛谷秀昭; 尾仲宏康

  日本農芸化学会大会講演要旨集(Web), 2014

  
• 新規ポリエンマクロラクタム8-deoxyheronamide Cの単離・構造決定とその生物活性

  杉山龍介; 西村慎一; 恒松雄太; 服部明; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2013

  
• 海洋由来放線菌が産生するheronamide類の単離と生物活性

  杉山龍介; 西村慎一; 松森信明; 恒松雄太; 服部明; 村田道雄; 掛谷秀昭

  天然有機化合物討論会講演要旨集(Web), 2013

  
• Synthetic Studies on (+)-Cytotrienin A, an Apoptosis Inducing Ansamycin Antibiotic

  岩渕好治; 佐藤亮; 笹野裕介; 小松慎吾; 野口正嗣; 掛谷秀昭; 長田裕之; 叶直樹

  天然有機化合物討論会講演要旨集(Web), 2018

  
• Chemical Space Expansion by Utilizing Rare Actinomycetes and Chemical Communications of Different Microbial Genera

  掛谷秀昭

  月刊ファインケミカル, 2021

  
• 経口投与可能なインターフェロン様活性を持つ低分子化合物CDMの抗HBV活性の解析

  古谷裕; 掛谷秀昭; 松浦知和; 松浦知和

  肝臓, 2020

  
• プロドラッグ型クルクミンCMGによる実験的自己免疫性脳脊髄炎の抑制と小腸細菌叢変化

  佐藤文孝; カドカ スンダル; 尾村誠一; 朴雅美; 藤田貢; 中村優美和; 西尾和人; 掛谷秀昭; 角田郁生

  Neuroimmunology, 2020

  
• Study on a new prodrug methodology inspired by a natural product saccharothriolide B

  竹中慧; 西村慎一; 金子賢介; LU Shan; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2020

  
• Synthetic study on the natural prodrug anticancer compound, saccharothriolide B

  田村美帆; 中川雄介; 倉永健史; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2020

  
• Functional correlation between USP47 and catenin D1 in cancer malignancy

  遠藤健太; 服部明; LI Xue-Bing; 小川裕樹; PAN Chengqian; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2020

  
• COPD患者において高吸収クルクミン製剤は動脈硬化に関連する炎症パラメーターを減少させた

  上原渉; 船本雅文; 船本雅文; 清水果奈; 清水果奈; 砂川陽一; 砂川陽一; 砂川陽一; 刀坂泰史; 刀坂泰史; 刀坂泰史; 宮崎雄輔; 宮崎雄輔; 宮崎雄輔; 今泉厚; 掛谷秀昭; 山影一; 浅原哲子; 和田啓道; 長谷川浩二; 長谷川浩二; 森本達也; 森本達也; 森本達也

  禁煙科学(Web), 2020

  
• インターフェロン様の活性を持つ低分子化合物CDM-3008の抗HBV活性の解析

  古谷裕; 戸口真理子; 戎井悦子; 樋口祥子; 須藤正幸; 鈴木治和; 掛谷秀昭; 小嶋聡一

  肝細胞研究会プログラム・抄録集, 2019

  
• 低酸素誘導因子(HIF-1)阻害化合物verucopeptinの生合成遺伝子クラスター同定と新規類縁体の探索

  金子賢介; 長尾野映花; 服部明; 掛谷秀昭

  日本分析化学会有機微量分析研究懇談会・計測自動制御学会力学量計測部会合同シンポジウム講演要旨集, 2019

  
• 抗酸化・抗炎症作用を有する高吸収クルクミン製剤はCOPD患者における酸化LDLを減少させた

  船本雅文; 船本雅文; 清水果奈; 清水果奈; 砂川陽一; 砂川陽一; 砂川陽一; 刀坂泰史; 刀坂泰史; 刀坂泰史; 宮崎雄輔; 宮崎雄輔; 宮崎雄輔; 掛谷秀昭; 山陰一; 浅原哲子; 和田啓道; 長谷川浩二; 長谷川浩二; 森本達也; 森本達也; 森本達也

  日本栄養・食糧学会大会講演要旨集, 2019

  
• 高吸収クルクミン製剤は2型糖尿病患者におけるAT-LDLの増加を抑制した

  清水果奈; 清水果奈; 船本雅文; 船本雅文; 砂川陽一; 砂川陽一; 刀坂泰史; 刀坂泰史; 宮崎雄輔; 宮崎雄輔; 掛谷秀昭; 山陰一; 和田啓道; 長谷川浩二; 長谷川浩二; 森本達也; 森本達也

  日本心不全学会学術集会プログラム・抄録集, 2019

  
• 低酸素応答シグナルを標的とした創薬ケミカルバイオロジー

  掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2019

  
• 水溶性プロドラッグ型分子標的抗がん剤CMGの開発研究

  掛谷秀昭

  日本がん分子標的治療学会学術集会プログラム・抄録集, 2019

  
• Involvement of UCHL1 in the HIF1-dependent tumor cell malignancy in 3D cell culture model

  李雪氷; 服部明; 後藤容子; 原田浩; 掛谷秀昭

  日本癌学会学術総会抄録集(Web), 2019

  
• Development of water-soluble pro-drug CMG which inhibits proteasome activity through DYRK2 dependent manner

  金井雅史; 岸本充弘; 梅田瞳; 今泉厚; 掛谷秀昭

  日本癌学会学術総会抄録集(Web), 2019

  
• ドラッグフリーの実現を目指したcccDNA抑制剤CDM-3008とエンテカビルとの併用によるHBV再活性化の抑制

  古谷裕; 掛谷秀昭; 小嶋聡一

  肝臓, 2018

  
• Natural products-inspired chemical biology toward development of new antibiotics

  掛谷秀昭

  Japanese Journal of Antibiotics, 2018

  
• Studies on the biosynthesis of novel alkaloids derived from the combined-culture of Streptomyces nigrescens HEK616 and Tsukamurella pulmonis

  尾崎太郎; 尾崎太郎; 浅水俊平; 尾仲宏康; 杉山龍介; 西村慎一; 掛谷秀昭

  Institute for Fermentation, Osaka. Research Communications, 2018

  
• 天然物創薬ケミカルバイオロジー-放線菌に魅せられて-

  掛谷秀昭

  日本放線菌学会大会講演要旨集, 2018

  
• 高吸収クルクミンは禁煙後のCOPD患者における動脈硬化に関連する炎症を抑制した

  清水果奈; 清水果奈; 船本雅文; 船本雅文; 砂川陽一; 砂川陽一; 砂川陽一; 刀坂泰史; 刀坂泰史; 刀坂泰史; 宮崎雄輔; 宮崎雄輔; 宮崎雄輔; 今泉厚; 掛谷秀昭; 山陰一; 浅原哲子; 和田啓道; 長谷川浩二; 長谷川浩二; 森本達也; 森本達也; 森本達也

  禁煙科学(Web), 2018

  
• Curcuminの主要な代謝産物であるCurcumin Glucuronide及びTetrahydrocurcuminの心筋細胞肥大抑制作用の検討

  望月沙穂; 砂川陽一; 砂川陽一; 砂川陽一; 船本雅文; 船本雅文; SARI Nurmila; 清水果奈; 清水果奈; 清水聡史; 刀坂泰史; 刀坂泰史; 刀坂泰史; 宮崎雄輔; 宮崎雄輔; 宮崎雄輔; 高橋伸明; 掛谷秀昭; 長谷川浩二; 長谷川浩二; 森本達也; 森本達也; 森本達也

  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会講演要旨集, 2018

  
• Discovery Scienceに魅せられて 天然物創薬ケミカルバイオロジーの最前線

  掛谷秀昭

  化学と生物, 2018

  
• TGF-βシグナル伝達阻害剤KUSC-Y244はTGF-βによる上皮間葉転換を抑制する

  杉崎俊文; 高須康明; 服部明; 小嶋聡一; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2018

  
• 天然Curcumin誘導体及び主要なCurcumin代謝産物を用いた心筋細胞肥大抑制作用の検討

  源平麻衣; 砂川陽一; 砂川陽一; 砂川陽一; 船本雅文; 船本雅文; 清水果奈; 清水果奈; 清水聡史; NURMILA Sari; 刀坂泰史; 刀坂泰史; 刀坂泰史; 宮崎雄輔; 宮崎雄輔; 宮崎雄輔; 高橋伸明; 掛谷秀昭; 和田啓道; 長谷川浩二; 森本達也; 森本達也; 森本達也

  日本薬学会年会要旨集(CD-ROM), 2018

  
• Saccharothriolide Bは腎細胞癌においてプロテアソーム経路非依存的にHIF-2αを分解する

  高橋千絵; 盧山; 蒋雨露; 東克暁; 西村慎一; 服部明; 掛谷秀昭

  日本生化学会大会(Web), 2018

  
• Calpain7の細胞内局在の解析

  松原拓真; 服部明; 掛谷秀昭

  日本生化学会大会(Web), 2018

  
• 酵素反応速度論的解析を用いた脱ユビキチン化酵素USP47のC末端領域の機能解析

  福岡啓太; 服部明; 掛谷秀昭

  日本生化学会大会(Web), 2018

  
• 生体膜を標的にする天然有機化合物 天然物による厳密な脂質認識とそれに基づく表現型

  西村慎一; 掛谷秀昭; 松森信明

  化学と生物, 2018

  
• cccDNA抑制剤CDM/iCDMとエンテカビルとの併用効果の解析

  古谷裕; 掛谷秀昭; 小嶋聡一

  肝臓, 2017

  
• プロドラッグ型クルクミンを用いた新規抗がん薬の開発

  金井雅史; 小澤瞳; 高橋伸明; 今泉厚; 掛谷秀昭

  日本臨床腫瘍学会学術集会(CD-ROM), 2017

  
• 機能性食品素材の医薬品への展開を目指した創薬ケミカルバイオロジー

  今泉厚; 高橋伸明; 光金英宣; 金井雅史; 橋本正; 牧野悠治; 津田孝範; 掛谷秀昭

  食品薬学シンポジウム講演要旨集, 2017

  
• UCHL1-HIF-1活性化経路を標的とした分子標的抗がん剤開発研究

  LI Xuebing; 服部明; 後藤容子; 森鳰章代; 平岡眞寛; 原田浩; 原田浩; 原田浩; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2017

  
• 心筋細胞肥大抑制作用におけるp300HAT活性阻害剤クルクミンとクルクミンデメトキシ誘導体の比較検討

  源平麻衣; 砂川陽一; 砂川陽一; 砂川陽一; 宗野匠吾; 清水果奈; 船本雅文; 船本雅文; 刀坂泰史; 宮崎雄輔; 掛谷秀昭; 和田啓道; 長谷川浩二; 森本達也; 森本達也; 森本達也

  日本薬学会年会要旨集(CD-ROM), 2017

  
• 脱ユビキチン化酵素USP47のC末端ホモロジー領域はそのポリユビキチン鎖認識機構に重要である

  福岡啓太; 服部明; 掛谷秀昭

  日本生化学会大会(Web), 2017

  
• Curcuminの主要な代謝産物であるCurcumin Glucuronideを用いた心筋細胞肥大抑制作用の検討

  源平麻衣; 砂川陽一; 砂川陽一; 砂川陽一; 船本雅文; 船本雅文; 清水果奈; 清水果奈; 刀坂泰史; 刀坂泰史; 刀坂泰史; 宮崎雄輔; 宮崎雄輔; 宮崎雄輔; 高橋伸明; 掛谷秀昭; 長谷川浩二; 長谷川浩二; 森本達也; 森本達也; 森本達也

  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会講演要旨集, 2017

  
• 高吸収クルクミンによりCOPD患者の動脈硬化に関連する炎症が抑制された

  船本雅文; 船本雅文; 砂川陽一; 砂川陽一; 砂川陽一; 刀坂泰史; 刀坂泰史; 刀坂泰史; 宮崎雄輔; 宮崎雄輔; 今泉厚; 掛谷秀昭; 山陰一; 浅原哲子; 和田啓道; 長谷川浩二; 森本達也; 森本達也; 森本達也

  日本薬理学雑誌, 2017

  
• 主要なCurcumin代謝物であるCurcumin glucuronidはp300HAT活性阻害及び心筋細胞肥大抑制作用を保持していた

  源平麻衣; 砂川陽一; 砂川陽一; 砂川陽一; 船本雅文; 船本雅文; 清水果奈; 清水果奈; 宮崎雄輔; 宮崎雄輔; 宮崎雄輔; 刀坂泰史; 刀坂泰史; 刀坂泰史; 高橋伸明; 掛谷秀昭; 和田啓道; 島津章; 長谷川浩二; 長谷川浩二; 森本達也; 森本達也; 森本達也

  日本薬理学雑誌, 2017

  
• Generation of Heronamides A and B from Heronamide C Produced by a Marine-Derived Streptomyces sp. and Their Antifungal Activity

  山前 結; 藤田 航平; 西村 慎一; 掛谷 秀昭

  ELCAS Journal, Mar. 2016

  
• インターフェロン様活性を持つ低分子化合物CDMによるcccDNA抑制作用の解析

  小嶋聡一; 古谷裕; 掛谷秀昭

  肝臓, 2016

  
• 脱ユビキチン化酵素USP47のポリユビキチン鎖消化に関わる分子内領域の同定

  福岡啓太; 青木豊; 服部明; 掛谷秀昭

  日本生化学会大会(Web), 2016

  
• ケミカルバイオロジーの新展開 表現型スクリーニングを基盤とした先導的天然物ケミカルバイオロジー

  LU Shan; 杉崎俊文; 岸本真治; 西村慎一; 掛谷秀昭

  化学工業, 2016

  
• 脱ユビキチン化酵素阻害によるHIF-1発現レベルの制御

  吹上遼介; 小林万祐子; 服部明; 掛谷秀昭

  日本生化学会大会(Web), 2016

  
• 感染症の脅威と闘う-ヒトマイクロバイオームと特殊培養デバイスの活用

  都築健悟; 掛谷秀昭

  化学, 2016

  
• Heronamides A-Cの全合成と構造改訂,および構造活性相関

  叶直樹; 伊東俊哉; 寺嶋優太; 坂西航平; 岩渕好治; 藤田航平; 杉山龍介; 西村慎一; 掛谷秀昭

  天然有機化合物討論会講演要旨集(Web), 2015

  
• 創薬ケミカルバイオロジー:シード分子開発と分子プロファイリング

  掛谷秀昭

  日本化学療法学会雑誌, 2015

  
• ステロール標的抗真菌剤の活性発現における細胞膜輸送バランスの重要性

  西村慎一; 掛谷秀昭

  バイオサイエンスとインダストリー, 2015

  
• 次世代生命基盤技術を用いたB型肝炎制圧のための創薬研究 IFN様小分子化合物CDE(cccDNA Eliminator)の設計・創製・ケミカルバイオロジー研究

  掛谷秀昭

  次世代生命基盤技術を用いたB型肝炎制圧のための創薬研究 平成26年度 総括・分担研究報告書, 2015

  
• 非リボソーム性ペプチド合成酵素のペプチジル担体タンパク質を標的としたケミカルプローブの開発研究

  笠井昭太; 石川文洋; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2015

  
• Chemical biology for drug discovery and target identification

  Hideaki Kakeya

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2014

  
• 脱Urm1化活性の検出および分子同定

  小林万祐子; 服部明; 青木豊; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2014

  
• 脱ユビキチン化酵素USP47の活性発現におけるC末端領域の役割

  青木豊; 朴錦花; 小林万祐子; 服部明; 掛谷秀昭

  日本病態プロテアーゼ学会学術集会プログラム抄録集, 2014

  
• アシルグアニジン構造を有する新規シデロフォアchlorocatechelin類の単離・構造決定,全合成,および生物活性

  岸本真治; 西村慎一; 服部明; 波多野和樹; 五十嵐雅之; 掛谷秀昭

  天然有機化合物討論会講演要旨集(Web), 2014

  
• 新規低酸素誘導因子HIF阻害剤の探索と構造活性相関研究

  YASUDA YORINOBU; NAWATA YUMI; ARAKAWA TAKEAKI; SHIMADA SAYAKA; HATTORI AKIRA; NISHIMURA SHIN'ICHI; OISHI SHIN'YA; FUJII NOBUTAKA; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2014

  
• Food ingredients-oriented chemical biology research

  掛谷秀昭

  浦上財団研究報告書, 2013

  
• 新規TGF‐βシグナル伝達阻害剤tryptopeptin Aおよび分子プローブの合成研究

  KASAI SHOTA; SAKAI YUKI; TSUNEMATSU YUTA; HATTORI AKIRA; OISHI SHIN'YA; FUJII NOBUTAKA; NISHIMURA SHIN'ICHI; KAKEYA HIDEAKI

  日本薬学会年会要旨集, 05 Mar. 2012

  
• HIGHLY ABSORPTIVE CURCUMIN IMPROVES LEFT VENTRICULAR DIASTOLIC FUNCTION REGARDLESS OF BLOOD PRESSURE IN HYPERTENSIVE PATIENTS

  Tatsuya Morimoto; Hiromichi Wada; Yoichi Sunagawa; Masatoshi Fujita; Hideaki Kakeya; Atsushi Imaizumi; Tadashi Hashimoto; Masaharu Akao; Yasufumi Katanasaka; Genta Osakada; Hirofumi Kambara; Hiroki Shiomi; Takeshi Kimura; Akira Shimatsu; Koji Hasegawa

  JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, Mar. 2012

  
• 低酸素誘導因子(HIF)活性化経路を阻害するverucopeptinの化学的解析研究

  吉村彩; 大塚紗織; 西村慎一; 服部明; 長田裕之; 掛谷秀昭

  天然有機化合物討論会講演要旨集(Web), 2012

  
• Effects of Highly Absorptive Curcumin on Systolic and Diastolic Function in Hypertensive Patients with Left Ventricular Hypertrophy

  Tatsuya Morimoto; Hiromichi Wada; Yoichi Sunagawa; Masatoshi Fujita; Hideaki Kakeya; Hiroki Sasaki; Atsushi Imaizumi; Tadashi Hashimoto; Masaharu Akao; Genta Osakada; Hirofumi Kambara; Osamu Doi; Hiroki Shiomi; Takeshi Kimura; Akira Shimatsu; Koji Hasegawa

  CIRCULATION, Nov. 2011

  
• 含水条件での連続反応を利用したpH依存型新規DNAアルキル化剤の設計

  永本祐樹; 服部 明; 掛谷秀昭; 竹本佳司; 高須清誠

  第9回次世代を担う有機化学シンポジウム, May 2011, Peer-reviewed

  
• 放線菌の生産する新規抗がんリード化合物tryptopeptin Aの化学構造決定

  TSUNEMATSU YUTA; HATTORI AKIRA; OISHI SHIN'YA; FUJII NOBUTAKA; NISHIMURA SHIN'ICHI; KAKEYA HIDEAKI

  日本薬学会年会要旨集, 05 Mar. 2011

  
• グランザイムBをレポーターに用いた脱ユビキチン化酵素測定法の構築

  服部明; PIAO Jinhua; 田代亜衣香; 森吉英子; 掛谷秀昭

  生化学, 2011

  
• ヒトC7orf24遺伝子の発現は転写開始点近傍の3ケ所のCCAAT配列によって正に制御される

  大野裕司; 服部明; 上田正道; 影山進; 吉貴達寛; 掛谷秀昭

  生化学, 2011

  
• 放線菌が生産する新規TGF‐βシグナル伝達阻害剤tryptopeptin Aの単離・構造解析と合成

  TSUNEMATSU YUTA; OISHI SHIN'YA; FUJII NOBUTAKA; NISHIMURA SHIN'ICHI; HATTORI AKIRA; KAKEYA HIDEAKI

  天然有機化合物討論会講演要旨集, 01 Sep. 2010

  
• ヒトC7orf24/GGCT遺伝子の転写はNF-Yにより活性化される

  大野裕司; 服部明; 上田正道; 影山進; 吉貴達寛; 掛谷秀昭

  生化学, 2010

  
• 脱ユビキチン化酵素USP47の酵素学的性状解析

  TASHIRO AIKA; HATTORI AKIRA; PIAO JINHUA; YAMADA AI; OISHI SHIN'YA; FUJII NOBUTAKA; KAKEYA HIDEAKI

  生化学, 2010

  
• HIF‐1機能制御化合物の評価系構築と探索研究

  HATTORI AKIRA; TSUNEMATSU YUTA; OTSUKA SAORI; TAKASU YASUAKI; NISHIMURA SHIN'ICHI; YAKURA TOORU; OISHI SHIN'YA; FUJII NOBUTAKA; SHIMIZU SHIRO; OSADA HIROYUKI; KAKEYA HIDEAKI

  日本薬学会年会要旨集, 05 Mar. 2009

  
• 血管新生抑制剤アザスピレンの分子標的解明のためのケミカルバイオロジー研究

  掛谷秀昭

  上原記念生命科学財団研究報告集(CD-ROM), 2009

  
• Inhibition of VEGF (vascular endothelial growth factor)/VEGF receptor system activation and in vivo tumor-induced angiogenesis by an anti-angiogenic small molecule epoxyquinol B

  H. Kamiyama; H. Kakeya; H. Osada

  EJC SUPPLEMENTS, Nov. 2006

  
• 理研天然化合物バンクの構築とスクリーニングへの利用

  斎藤臣雄; 植木雅志; 清水史郎; 臼井健郎; 叶直樹; 今野英明; 掛谷秀昭; 富木毅; 長田裕之

  日本農芸化学会大会講演要旨集, 2006

  
• CytoxazoneによるTGF-βシグナル伝達抑制を介する肝疾患の制御

  近藤和嘉子; 掛谷秀昭; 渡部徹郎; 河田則文; 奥野正隆; 森脇久隆; 宮園浩平; 長田裕之; 小嶋聡一

  肝臓, 2005

  
• Epoxyquinols A and B, novel antiangiogenic agents.

  H Kakeya; R Onose; H Osada

  CLINICAL CANCER RESEARCH, Dec. 2003

  
• Inhibition of angiogenesis by a novel natural occurring antiangiogenic agent, azaspirene.

  Y Asami; H Kakeya; H Osada

  CLINICAL CANCER RESEARCH, Dec. 2003

  
• 構造活性相関に基づいたアポトーシス誘導物質サイトトリエニンAのプローブ合成

  叶直樹; 掛谷秀昭; 長田裕之

  日本農芸化学会大会講演要旨集, 2002

  
• 新規細胞周期阻害剤RK-9794に関する研究

  掛谷秀昭; 影山俊一郎; NIE L; 小野瀬利恵; 岡田元; 植木雅志; 別府輝彦; NORBURY C; 長田裕之

  日本農芸化学会誌, 2001

  
• Activation of MST/Krs proteins during anticancer drugs-induced apoptosis

  OSADA Hiroyuki; WATABE Masahiko; KAKEYA Hideaki

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• 抗がん剤によるMST/Krsタンパク質の活性化とアポトーシス誘導

  長田裕之; 渡部正彦; 掛谷秀昭

  日本分子生物学会年会プログラム・講演要旨集, Nov. 1998

  
• HL-60細胞におけるMT-21のアポトーシス誘導機構に関する研究

  渡部 正彦; 掛谷 秀昭; 長田 裕之

  日本癌学会総会記事, Aug. 1998

  
• Neuritogenic effect of epolactaene derivatives on human neuroblastoma cells which lack high affinity NGF-receptor

  H Kakeya; C Onozawa; H Osada

  FASEB JOURNAL, Jul. 1997

  
• Spirotryprostatin B, a novel mammalian cell cycle inhibitor produced by Aspergillus fumigatus

  CB Cui; H Kakeya; H Osada

  JOURNAL OF ANTIBIOTICS, Aug. 1996

  
• 新規細胞周期阻害剤typorostatin AおよびBの構造と活性 : 有機化学・天然物化学

  崔 承彬; 生方 信; 掛谷 秀昭; 長田 裕之

  日本農藝化學會誌, 05 Mar. 1996

  
• 新規細胞周期阻害剤acetophthalidinの構造、性質と活性 : 有機化学・天然物化学

  崔 承彬; 生方 信; 掛谷 秀昭; 長田 裕之

  日本農藝化學會誌, 05 Mar. 1996

  
• Study on polishing using micro motor. Polishing process in practical training and surface roughness of polished surface.

  林純子; 川田善彦; 中野秀昭; 刑部仁三; 掛谷昌宏; 広瀬英晴; 西山実

  日本大学歯技会雑誌, 1996

  
• 新規細胞増殖調節物質Sparoxomycin A1, A2 : 有機化学・天然物化学

  生方 信; 森田 徹一郎; 掛谷 秀昭; 小日向 君江; 工藤 卓二; 浦本 昌和; 長田 裕之

  日本農藝化學會誌, 05 Jul. 1995

  
• DEPHOSTATIN, A NOVEL PROTEIN-TYROSINE-PHOSPHATASE INHIBITOR PRODUCED BY STREPTOMYCES .1. TAXONOMY, ISOLATION, AND CHARACTERIZATION (VOL 46, PG 1342, 1993)

  M IMOTO; H KAKEYA; T SAWA; C HAYASHI; M HAMADA; T TAKEUCHI; K UMEZAWA

  JOURNAL OF ANTIBIOTICS, Feb. 1994

  
• Correction: Dephostatin, a novel protein tyrosine phosphatase inhibitor produced by Streptomyces. I. Taxonomy, isolation, and characterization (Journal of Antibiotics (1993) 46 (1342-1346))

  Imoto M; Kakeya H; Sawa T; Hayashi C; Hamada M; Takeuchi T; Umezawa K

  Journal of Antibiotics, 1994

  
• Microbial Hydrolysis of 3-Substituted Glutaronitriles

  Hideaki Kakeya; Naoko Sakai; Akio Sano; Masahiro Yokoyama; Takeshi Sugai; Hiromichi Ohta

  Chem. Lett, 1991

  

Presentations

• 天然Curcumin誘導体及び主要なCurcumin代謝産物を用いた心筋細胞肥大抑制作用の検討

  源平麻衣; 砂川陽一; 砂川陽一; 砂川陽一; 船本雅文; 船本雅文; 清水果奈; 清水果奈; 清水聡史; NURMILA Sari; 刀坂泰史; 刀坂泰史; 刀坂泰史; 宮崎雄輔; 宮崎雄輔; 宮崎雄輔; 高橋伸明; 掛谷秀昭; 和田啓道; 長谷川浩二; 森本達也; 森本達也; 森本達也

  日本薬学会年会要旨集(CD-ROM), 2018

  
• TGF‐βシグナル伝達阻害剤KUSC‐Y244はTGF‐βによる上皮間葉転換を抑制する

  杉崎俊文; 高須康明; 服部明; 小嶋聡一; 掛谷秀昭

  日本薬学会年会要旨集(CD-ROM), 2018

  
• 機能性食品素材の医薬品への展開を目指した創薬ケミカルバイオロジー

  今泉厚; 高橋伸明; 光金英宣; 金井雅史; 橋本正; 牧野悠治; 津田孝範; 掛谷秀昭

  食品薬学シンポジウム講演要旨集, 10 Oct. 2017

  
• 複合培養によって生産されるテトラヒドロキノリン化合物の解析

  下村杜人; 尾崎太郎; 杉山龍介; 西村慎一; 浅水俊平; 掛谷秀昭; 尾仲宏康

  日本放線菌学会大会講演要旨集, 07 Sep. 2017

  
• アカデミア創薬における表現型スクリーニングと次世代型天然物化学

  掛谷秀昭

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2017

  
• Curcuminの主要な代謝産物であるCurcumin Glucuronideを用いた心筋細胞肥大抑制作用の検討

  源平麻衣; 砂川陽一; 砂川陽一; 砂川陽一; 船本雅文; 船本雅文; 清水果奈; 清水果奈; 刀坂泰史; 刀坂泰史; 刀坂泰史; 宮崎雄輔; 宮崎雄輔; 宮崎雄輔; 高橋伸明; 掛谷秀昭; 長谷川浩二; 長谷川浩二; 森本達也; 森本達也; 森本達也

  日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会講演要旨集, 2017

  
• 脱ユビキチン化酵素USP47のC末端ホモロジー領域はそのポリユビキチン鎖認識機構に重要である

  福岡啓太; 服部明; 掛谷秀昭

  日本生化学会大会(Web), 2017

  
• 心筋細胞肥大抑制作用におけるp300HAT活性阻害剤クルクミンとクルクミンデメトキシ誘導体の比較検討

  源平麻衣; 砂川陽一; 砂川陽一; 砂川陽一; 宗野匠吾; 清水果奈; 船本雅文; 船本雅文; 刀坂泰史; 宮崎雄輔; 掛谷秀昭; 和田啓道; 長谷川浩二; 森本達也; 森本達也; 森本達也

  日本薬学会年会要旨集(CD-ROM), 2017

  
• アデニレーションドメインに対する活性部位指向型プローブを用いた非リボソーム性ペプチド合成酵素活性のプロファイリング

  KONNO SHO; ISHIKAWA FUMIHIRO; SUZUKI TAKEHIRO; DOMAE NAOSHI; KAKEYA HIDEAKI

  日本蛋白質科学会年会プログラム・要旨集, 26 May 2015

  
• アデニレーションドメインに対する活性部位指向型プローブの開発

  KONNO SHO; ISHIKAWA FUMIHIRO; SUZUKI TAKEHIRO; DOMAE NAOSHI; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2015

  
• 非リボソーム性ペプチド合成酵素のペプチジル担体タンパク質を標的としたケミカルプローブの開発研究

  KASAI SHOTA; ISHIKAWA FUMIHIRO; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2015

  
• Heronamide AおよびBの生成機構に関する研究

  FUJITA KOHEI; SUGIYAMA RYUSUKE; NISHIMURA SHIN'ICHI; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2015

  
• 創薬シーズ開発を指向した天然物ケミカルバイオロジー―表現型スクリーニングと標的探索・同定―

  KAKEYA HIDEAKI

  天然薬物の開発と応用シンポジウム講演要旨集, 01 Nov. 2014

  
• アデニレーションドメインに対するテーラメイドケミカルラベリング法の開発

  ISHIKAWA FUMIHIRO; KONNO SHO; KAKEYA HIDEAKI

  天然薬物の開発と応用シンポジウム講演要旨集, 01 Nov. 2014

  
• 複合培養を利用した新規テトラヒドロキノリン類の単離とその生合成に関する研究

  OZAKI TARO; SUGIYAMA RYUSUKE; NISHIMURA SHIN'ICHI; ASAMIZU SHUMPEI; KAKEYA HIDEAKI; ONAKA HIROYASU

  日本放線菌学会大会講演要旨集, 19 Jun. 2014

  
• 放線菌の複合培養法による新規テトラヒドロキノリン類の単離とその生合成

  OZAKI TARO; MORI YUKIKO; SUGIYAMA RYUSUKE; NISHIMURA SHIN'ICHI; ASAMIZU SHUMPEI; KAKEYA HIDEAKI; ONAKA HIROYASU

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2014

  
• 抗腫瘍性環状デプシペプチドverucopeptinの全合成研究

  TAKAHASHI NOBUAKI; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2014

  
• 脱ユビキチン化酵素USP47の活性発現におけるC末端領域の役割

  AOKI YUTAKA; BOKU KINKA; KOBAYASHI MAYUKO; HATTORI AKIRA; KAKEYA HIDEAKI

  日本病態プロテアーゼ学会学術集会プログラム抄録集, 2014

  
• 脱Urm1化活性の検出および分子同定

  KOBAYASHI MAYUKO; HATTORI AKIRA; AOKI YUTAKA; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2014

  
• 脱ユビキチン化酵素(USP)47の分子内ドメインの機能解析

  AOKI YUTAKA; BOKU KINKA; KOBAYASHI MAYUKO; HATTORI AKIRA; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2014

  
• 微生物機能を活用した創薬ケミカルバイオロジー研究

  KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2014

  
• 低酸素誘導因子(HIF)活性化経路を阻害するverucopeptinの作用機序解析

  YOSHIMURA AYA; NISHIMURA SHIN'ICHI; OTSUKA SAORI; HATTORI AKIRA; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2014

  
• 新規低酸素誘導因子HIF阻害剤の探索と構造活性相関研究

  YASUDA YORINOBU; NAWATA YUMI; ARAKAWA TAKEAKI; SHIMADA SAYAKA; HATTORI AKIRA; NISHIMURA SHIN'ICHI; OISHI SHIN'YA; FUJII NOBUTAKA; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2014

  
• 無作為割付クロスオーバー2重盲検試験によってTheracurminは他のクルクミン製剤よりも優れた吸収効率の向上がみられた

  OKAMURA NOBUKO; SUNAKAWA YOICHI; TOSAKA YASUFUMI; HIRANO SAE; NAMIKI MASATOSHI; WATANABE YUICHI; DOI OSAMU; YOKOCHI TSUNEHIRO; TAKAHASHI TSUKASA; MATSUI MUNEHITO; HAMADA TOMOKO; IMAIZUMI ATSUSHI; HASHIMOTO TADASHI; KAKEYA HIDEAKI; WADA KEIDO; SHIMAZU AKIRA; HASEGAWA KOJI; MORIMOTO TATSUYA

  日本薬学会年会要旨集(CD-ROM), 2014

  
• 光親和性プローブを利用したアデニレーションドメインのリガンド依存的標識化

  KONNO SHO; ISHIKAWA FUMIHIRO; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2014

  
• テトラヒドロキノリン骨格を有する新規放線菌代謝物の構造多様性と生物活性

  SUGIYAMA RYUSUKE; NISHIMURA SHIN'ICHI; OZAKI TARO; ONAKA HIROYASU; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2014

  
• Chaetoglobosin DはROS産生により細胞のセリン資化を阻害する。

  KANO AKIHIKO; NISHIMURA SHIN'ICHI; KATO TAIRA; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2014

  
• Streptomyces属放線菌より見出した塩素原子含有新規シデロフォアの単離・構造決定

  KISHIMOTO SHINJI; NISHIMURA SHIN'ICHI; HATTORI AKIRA; HATANO KAZUKI; IGARASHI MASAYUKI; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2014

  
• 無作為割付クロスオーバー2重盲検試験によりクルクミン製剤Theracurminは既存のクルクミン製剤よりも優れた経口吸収性を示した

  SUNAGAWA YOICHI; HIRANO SAE; OKAMURA NOBUKO; KATANASAKA YASUFUMI; DOI OSAMU; YOKOCHI TSUNEHIRO; TAKAHASHI TSUKASA; IMAIZUMI ATSUSHI; HASHIMOTO TADASHI; KAKEYA HIDEAKI; WADA KEIDO; SHIMAZU AKIRA; HASEGAWA KOJI; MORIMOTO TATSUYA

  日本抗加齢医学会総会プログラム・抄録集, 2014

  
• TGF‐βシグナル阻害活性を有する天然物トリプトペプチンAの標的分子探索研究

  KASAI SHOTA; SAKAI YUKI; TSUNEMATSU YUTA; HATTORI AKIRA; NISHIMURA SHIN'ICHI; KAKEYA HIDEAKI

  食品薬学シンポジウム講演要旨集, 01 Oct. 2013

  
• セリン代謝はアクチン阻害剤への感受性を上昇させる

  KANO AKIHIKO; NISHIMURA SHIN'ICHI; KATO TAIRA; KAKEYA HIDEAKI

  食品薬学シンポジウム講演要旨集, 01 Oct. 2013

  
• 糸状菌Neosartorya属由来プレニル基転移酵素に関する研究

  MIYAMOTO KENGO; ISHIKAWA FUMIHIRO; HAYASHI YUTAKA; KAKEYA HIDEAKI

  食品薬学シンポジウム講演要旨集, 01 Oct. 2013

  
• ステロールリッチ細胞膜ドメインの形成機構の解析

  NISHIMURA SHIN'ICHI; TOKUKURA MASATO; OCHI JUNKO; YOSHIDA MINORU; KAKEYA HIDEAKI

  食品薬学シンポジウム講演要旨集, 01 Oct. 2013

  
• アカデミア発の創薬を夢見て―化学療法基盤支援活動の魅力

  YAMORI TAKAO; IMOTO MASAYA; UEHARA YOSHIMASA; OSADA HIROYUKI; KAKEYA HIDEAKI; KAWADA MANABU; SEIMIYA HIROYUKI; DAN SHINGO; TOMIDA AKIHIRO; FUKAZAWA HIDESUKE; MASHIMA TETSUO; MATSUURA MASAAKI; MIZUKAMI TAMIO; YOSHIDA MINORU

  食品薬学シンポジウム講演要旨集, 01 Oct. 2013

  
• アミノ酸代謝を変調する天然化合物の探索研究

  KANO AKIHIKO; NISHIMURA SHIN'ICHI; KAKEYA HIDEAKI

  日本がん分子標的治療学会学術集会プログラム・抄録集, 31 May 2013

  
• 低酸素誘導因子(HIF)活性化経路を阻害する放線菌由来verucopeptinの絶対立体配置の決定

  YOSHIMURA AYA; NISHIMURA SHIN'ICHI; HATTORI AKIRA; KAKEYA HIDEAKI

  日本がん分子標的治療学会学術集会プログラム・抄録集, 31 May 2013

  
• 脱SUMO化酵素SENP1阻害剤の探索

  ITO AKIHIRO; KAKEYA HIDEAKI; YOSHIDA MINORU

  日本がん分子標的治療学会学術集会プログラム・抄録集, 31 May 2013

  
• LC‐MS/MSを用いたケミカルプローブに対する標的タンパク質の同定

  ISHIKAWA FUMIHIRO; KAKEYA HIDEAKI

  日本蛋白質科学会年会プログラム・要旨集, 31 May 2013

  
• 新規セラクルミン配合飲料は既存のクルクミン飲料よりも高い吸収効率を示した

  SUNAGAWA YOICHI; KATANASAKA YASUFUMI; HIRANO SAE; NAMIKI MASATOSHI; WATANABE YUICHI; DOI OSAMU; SUZUKI KIYOMI; YAMAUCHI MIYUKI; YOKOJI TSUNEHIRO; OTSUKA YOSHIHIKO; HAMADA TOMOKO; IMAIZUMI ATSUSHI; NONAKA YUJI; FUWA TAKASHI; TERAMOTO TAKANORI; KAKEYA HIDEAKI; WADA HIROMICHI; SHIMAZU AKIRA; HASEGAWA KOJI; MORIMOTO TATSUYA

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2013

  
• 脱ユビキチン化酵素(USP)47の活性発現機構の解析

  BOKU KINKA; HATTORI AKIRA; AOKI YUTAKA; KOBAYASHI MAYUKO; MORIYOSHI EIKO; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2013

  
• 分子機能変換を指向した糸状菌Neosartorya sp.由来プレニル基転移酵素の機能解析

  MIYAMOTO KENGO; ISHIKAWA FUMIHIRO; HAYASHI YUTAKA; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2013

  
• 新規ポリエンマクロラクタム8‐deoxyheronamide Cの単離・構造決定とその生物活性

  SUGIYAMA RYUSUKE; NISHIMURA SHIN'ICHI; TSUNEMATSU YUTA; HATTORI AKIRA; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2013

  
• 4製剤無作為割付クロスオーバー2重盲検試験により,セラクルミン配合飲料の高い吸収効率が実証された

  KATANASAKA YASUFUMI; SAGAWA YOICHI; NAMIKI MASATOSHI; HIRANO SAE; WATANABE YUICHI; SUZUKI KIYOMI; YAMAUCHI MIYUKI; YOKOCHI TSUNEHIRO; HAMADA TOMOKO; OTSUKA YOSHIHIKO; IMAIZUMI ATSUSHI; NONAKA YUJI; FUWA TAKASHI; TERAMOTO TAKANORI; WADA KEIDO; KAKEYA HIDEAKI; DOI OSAMU; HASEGAWA KOJI; MORIMOTO TATSUYA

  日本薬学会年会要旨集(CD-ROM), 2013

  
• 1,3‐Dimethyl鎖状構造の立体配置決定法の検証:tumescenamide Cとverucopeptinを例に

  YOSHIMURA AYA; NISHIMURA SHIN'ICHI; KISHIMOTO SHINJI; HATTORI AKIRA; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2013

  
• 有用生合成酵素の同定・機能解析を指向した化学ツールの開発―adenylationドメインを標的とした高親和性プローブの開発―

  ISHIKAWA FUMIHIRO; KAKEYA HIDEAKI

  日本薬学会年会要旨集(CD-ROM), 2013

  
• 3β‐Hydroxysteroid dehydrogenase(3β‐HSD)阻害剤の開発研究

  SAKAI YUKI; NISHIMURA SHIN'ICHI; HATTORI AKIRA; OTA TAKUMI; DOI MASAO; OKAMURA HITOSHI; KAKEYA HIDEAKI

  メディシナルケミストリーシンポジウム講演要旨集, 01 Nov. 2012

  
• 低酸素誘導因子(HIF)活性化経路を阻害するverucopeptinに関する研究

  YOSHIMURA AYA; OTSUKA SAORI; NISHIMURA SHIN'ICHI; HATTORI AKIRA; KAKEYA HIDEAKI

  天然薬物の開発と応用シンポジウム講演要旨集, 01 Oct. 2012

  
• P-26 Elucidation of the Stereochemistry of Verucopeptin, a New Inhibitor of HIF-signaling pathway(Poster Presentation)

  Yoshimura Aya; Otsuka Saori; Nishimura Shinichi; Hattori Akira; Osada Hiroyuki; Kakeya Hideaki

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Sep. 2012

  
• “ものとり”・“ものづくり”を基盤としたケミカルバイオロジー研究

  KAKEYA HIDEAKI

  日本農芸化学会大会講演要旨集(Web), 05 Mar. 2012

  
• 二分子蛍光相補システムを利用した低酸素誘導因子(HIF)阻害剤活性評価系の構築

  KO GYOTEN; HATTORI AKIRA; TOKIWA REI; KAKEYA HIDEAKI

  日本薬学会年会要旨集, 05 Mar. 2012

  
• TGF‐βシグナル伝達系を阻害する新規サイトキサゾン誘導体の合成および標的タンパク質探索用光標識プローブの開発

  HAKETA TADASU; ISHII HIDEKI; HATTORI AKIRA; KAKEYA HIDEAKI; KOJIMA SOICHI; SUZUKI MASAAKI

  日本薬学会年会要旨集, 05 Mar. 2012

  
• ヒトUSP47の脱ユビキチン化酵素活性の解析

  BOKU KINKA; TASHIRO AIKA; NISHIKAWA MIKIKO; MORIYOSHI EIKO; HATTORI AKIRA; KAKEYA HIDEAKI

  日本薬学会年会要旨集, 05 Mar. 2012

  
• 生体膜を解析する化学遺伝学

  NISHIMURA SHIN'ICHI; KAKEYA HIDEAKI

  日本薬学会年会要旨集, 05 Mar. 2012

  
• 放線菌が生産する新規テトラヒドロキノリン誘導体の単離・構造解析

  SUGIYAMA RYUSUKE; NISHIMURA SHIN'ICHI; MORI YUKIKO; ONAKA HIROYASU; KAKEYA HIDEAKI

  日本薬学会年会要旨集, 05 Mar. 2012

  
• 脱ユビキチン化酵素UCH‐L3は酸化ストレス下で不活性化される

  NISHIKAWA MIKIKO; KOBAYASHI MAYUKO; BOKU KINKA; MORIYOSHI EIKO; HATTORI AKIRA; KAKEYA HIDEAKI

  日本薬学会年会要旨集, 05 Mar. 2012

  
• 新規TGF‐βシグナル伝達阻害剤tryptopeptin Aおよび分子プローブの合成研究

  KASAI SHOTA; SAKAI YUKI; TSUNEMATSU YUTA; HATTORI AKIRA; OISHI SHIN'YA; FUJII NOBUTAKA; NISHIMURA SHIN'ICHI; KAKEYA HIDEAKI

  日本薬学会年会要旨集, 05 Mar. 2012

  
• 脱ユビキチン化酵素(USP)47の活性発現における分子内ユビキチン様ドメインの役割

  PIAO JINHUA; HATTORI AKIRA; AOKI YUTAKA; KOBAYASHI MAYUKO; MORIYOSHI EIKO; KAKEYA HIDEAKI

  日本生化学会大会(Web), 2012

  
• 脱ユビキチン化酵素UCH‐L3は酸化ストレスの標的タンパク質である

  HATTORI AKIRA; NISHIKAWA MINAKO; PIAO JINHUA; KOBAYASHI MAYUKO; MORIYOSHI EIKO; KAKEYA HIDEAKI

  日本生化学会大会(Web), 2012

  
• エピジェネティックな制御によるヒトC7orf24遺伝子発現調節

  HATTORI AKIRA; ONO YUJI; KAKEYA HIDEAKI

  日本病態プロテアーゼ学会学術集会プログラム抄録集, 2012

  
• 放線菌が産生する新規環状リポデプシペプチドpentadepsin Aに関する研究

  KISHIMOTO SHINJI; TSUNEMATSU YUTA; NISHIMURA SHIN'ICHI; HATTORI AKIRA; KAKEYA HIDEAKI

  天然有機化合物討論会講演要旨集, 02 Sep. 2011

  
• P-43 Pentadepsin A, a Novel Lipodepsipeptide Produced by Streptomyces sp.(Poster Presentation)

  Kishimoto Shinji; Tsunematsu Yuta; Nishimura Shinichi; Hattori Akira; Kakeya Hideaki

  Symposium on the Chemistry of Natural Products, symposium papers, 02 Sep. 2011

  
• 含水条件での連続反応を利用したpH依存型新規DNAアルキル化剤の設計

  NAGAMOTO YUKI; HATTORI AKIRA; KAKEYA HIDEAKI; TAKEMOTO YOSHIJI; TAKASU KIYOSEI

  次世代を担う有機化学シンポジウム講演要旨集, 22 May 2011

  
• 脱ユビキチン化酵素活性の新しい測定法の確立

  HATTORI AKIRA; TASHIRO AIKA; MORIYOSHI EIKO; BOKU KINKA; KAKEYA HIDEAKI

  日本薬学会年会要旨集, 05 Mar. 2011

  
• 微生物メタボローム解析により見出した新規環状リポデプシペプチド

  KISHIMOTO SHINJI; TSUNEMATSU YUTA; NISHIMURA SHIN'ICHI; HATTORI AKIRA; KAKEYA HIDEAKI

  日本薬学会年会要旨集, 05 Mar. 2011

  
• 血管新生阻害剤azaspireneの作用機序解析と標的タンパク質探索

  NAKAJIMA KOZUE; HATTORI AKIRA; TSUNEMATSU YUTA; NISHIMURA SHIN'ICHI; SHOJI MITSURU; HAYASHI YUJIRO; OSADA HIROYUKI; KAKEYA HIDEAKI

  日本薬学会年会要旨集, 05 Mar. 2011

  
• 放線菌の生産する新規抗がんリード化合物tryptopeptin Aの化学構造決定

  TSUNEMATSU YUTA; HATTORI AKIRA; OISHI SHIN'YA; FUJII NOBUTAKA; NISHIMURA SHIN'ICHI; KAKEYA HIDEAKI

  日本薬学会年会要旨集, 05 Mar. 2011

  
• グランザイムBをレポーターに用いた脱ユビキチン化酵素測定法の構築

  HATTORI AKIRA; PIAO JINHUA; TASHIRO AIKA; MORIYOSHI EIKO; KAKEYA HIDEAKI

  生化学, 2011

  
• ヒトC7orf24遺伝子の発現は転写開始点近傍の3ケ所のCCAAT配列によって正に制御される

  ONO YUJI; HATTORI AKIRA; UEDA MASAMICHI; KAGEYAMA SUSUMU; YOSHIKI TATSUHIRO; KAKEYA HIDEAKI

  生化学, 2011

  
• 新規血管新生阻害物質RQN‐18690Aの生合成遺伝子群のクローニング

  HAYASHI YUTAKA; NAKAMURA TAKURO; OSHIMA KENSHIRO; HATTORI MASAHIRA; OSADA HIROYUKI; KAKEYA HIDEAKI

  日本放線菌学会大会講演要旨集, 02 Sep. 2010

  
• Isolation, Structure Elucidation and Synthesis of Tryptopeptin A,a Novel TGF-β Signaling Pathway Inhibitor Produced by Streptomyces sp.

  TSUNEMATSU Yuta; OISHI Shinya; FUJII Nobutaka; NISHIMURA Shinichi; HATTORI Akira; KAKEYA Hideaki

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Sep. 2010

  
• 放線菌が生産する新規TGF‐βシグナル伝達阻害剤tryptopeptin Aの単離・構造解析と合成

  TSUNEMATSU YUTA; OISHI SHIN'YA; FUJII NOBUTAKA; NISHIMURA SHIN'ICHI; HATTORI AKIRA; KAKEYA HIDEAKI

  天然有機化合物討論会講演要旨集, 01 Sep. 2010

  
• ヒトC7orf24/GGCT遺伝子の転写はNF‐Yにより活性化される

  ONO YUJI; HATTORI AKIRA; UEDA MASAMICHI; KAGEYAMA SUSUMU; YOSHIKI TATSUHIRO; KAKEYA HIDEAKI

  生化学, 2010

  
• 脱ユビキチン化酵素USP47の酵素学的性状解析

  TASHIRO AIKA; HATTORI AKIRA; PIAO JINHUA; YAMADA AI; OISHI SHIN'YA; FUJII NOBUTAKA; KAKEYA HIDEAKI

  生化学, 2010

  
• HIF‐1機能制御化合物の評価系構築と探索研究

  HATTORI AKIRA; TSUNEMATSU YUTA; OTSUKA SAORI; TAKASU YASUAKI; NISHIMURA SHIN'ICHI; YAKURA TOORU; OISHI SHIN'YA; FUJII NOBUTAKA; SHIMIZU SHIRO; OSADA HIROYUKI; KAKEYA HIDEAKI

  日本薬学会年会要旨集, 05 Mar. 2009

  
• 微生物資源を基盤としたケミカルバイオロジー研究

  KAKEYA HIDEAKI

  天然薬物の開発と応用シンポジウム講演要旨集, 01 Nov. 2008

  
• 沈香の香気成分生成に関与するテルペン合成酵素遺伝子の解析研究

  YAGURA TOORU; KAKEYA HIDEAKI; ITO MICHIHO; HONDA YOSHIAKI

  日本生薬学会年会講演要旨集, 01 Sep. 2008

  
• アンサマイシン系抗腫瘍天然物,サイトトリエニンAの全合成

  HAYASHI YUJIRO; SHOJI MITSURU; ISHIKAWA HAYATO; YAMAGUCHI JUN'ICHIRO; TAMURA TOMOHIRO; IMAI HIROKI; NISHIGAYA YOSUKE; TAKABE KEN'ICHI; KAKEYA HIDEAKI; OSADA HIROYUKI

  天然有機化合物討論会講演要旨集, 01 Sep. 2008

  
• 13 The Asymmetric Total Synthesis of(+)-Cytotrienin A, an Ansamycin-type Anticancer Drug(Oral Presentation)

  Hayashi Yujiro; Mitsuru Shoji; Ishikawa Hayato; Yamaguchi Junichiro; Tamura Tomohiro; Imai Hiroaki; Nishigaya Yosuke; Takabe Kenichi; Kakeya Hideaki; Osada Hiroyuki

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Sep. 2008

  
• 放線菌が生産する新規piericidin類縁体に関する研究

  MORI MIHOKO; KAKEYA HIDEAKI; ICHIMIYA HARUMI; NEGISHI SHIGENORI; OSADA HIROYUKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2008

  
• “ものとり”を基盤としたケミカルバイオロジー研究

  KAKEYA HIDEAKI

  日本薬学会年会要旨集, 05 Mar. 2008

  
• 微生物代謝産物由来の新規バイオプローブの探索とケミカルバイオロジー研究

  KAKEYA HIDEAKI; OSADA HIROYUKI

  ケミカルバイオロジーシンポジウム発表要旨集 第4回 化学-生物融合領域創成の軌跡 理研シンポジウム 平成20年, 2008

  
• Panepophenanthrinの不斉全合成及びその構造活性相関

  HAYASHI YUJIRO; MATSUZAWA MASAYOSHI; YAMAGUCHI JUN'ICHIRO; SHOJI MITSURU; KAKEYA HIDEAKI; ONOSE RIE; OSADA HIROYUKI

  天然有機化合物討論会講演要旨集, 24 Aug. 2007

  
• P-62 Enantio- and Diastereoselective Total Synthesis of (+)-Panepophenanthrin, a Ubiquitin- Activating Enzyme Inhibitor, and Biological Properties of Its New Derivatives

  Hayashi Yujiro; Matsuzawa Masayoshi; Yamaguchi Junichiro; Shoji Mitsuru; Kakeya Hideaki; Onose Rie; Osada Hiroyuki

  Symposium on the Chemistry of Natural Products, symposium papers, 24 Aug. 2007

  
• 酸化的二量化反応によるepoxyquinol Bの合成における添加剤の効果について

  HAYASHI YUJIRO; MUKAIDA MAKOTO; SHOJI MITSURU; KAKEYA HIDEAKI; OSADA HIROYUKI

  日本化学会講演予稿集, 12 Mar. 2007

  
• Aspergillus fumigatusトリプロスタチン生産株(BM939)とゲノム解読株(Af293)の二次代謝産物の比較検討

  TAKAGI UMI; ASAMI YUKIHIRO; KATO NAOKI; URAMOTO MASAKAZU; KAKEYA HIDEAKI; OSADA HIROYUKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2007

  
• 放線菌が生産する新規細胞周期阻害剤RK‐2215Aに関する研究

  MORI MIHOKO; KAKEYA HIDEAKI; ICHIMIYA HARUMI; NEGISHI SHIGENORI; OSADA HIROYUKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2007

  
• Aspergillus fumigatusのトリプロスタチン生合成遺伝子クラスターの解析

  KATO NAOKI; TAKAGI UMI; ASAMI YUKIHIRO; KAKEYA HIDEAKI; OSADA HIROYUKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2007

  
• RIKEN Natural Products Encyclopedia (RIKEN NPEdia), a chemical database of RIKEN Natural Products Depository (RIKEN NPDepo)

  TOMIKI TAKESHI; SAITO TAMIO; UEKI MASASHI; KONNO HIDEAKI; ASAOKA TAKEO; ASAOKA TAKEO; SUZUKI RYUICHIRO; URAMOTO MASAKAZU; KAKEYA HIDEAKI; OSADA HIROYUKI

  情報化学討論会講演要旨集, 07 Nov. 2006

  
• Epoxyquinol Bの腫瘍血管新生抑制効果

  KAMIYAMA HIROSHI; KAKEYA HIDEAKI; MIYAZAKI OSAMU; NISHIKAWA KIYOHIRO; OSADA HIROYUKI

  日本癌学会学術総会記事, 28 Aug. 2006

  
• 血管新生阻害剤フマギリンによるエイズウイルスVprタンパク質阻害機構の解析

  WATANABE NOBUMOTO; KAKEYA HIDEAKI; OSADA HIROYUKI

  日本癌学会学術総会記事, 28 Aug. 2006

  
• Total Synthesis of Panepophenanthrin

  HAYASHI YUJIRO; MATSUZAWA MASAYOSHI; YAMAGUCHI JUN'ICHIRO; SHOJI MITSURU; KAKEYA HIDEAKI; ONOSE RIE; OSADA HIROYUKI

  日本化学会講演予稿集, 13 Mar. 2006

  
• Enantio- and Diastereo-selective Total Synthesis of Ovalicin

  YAMAGUCHI JUN'ICHIRO; SHOJI MITSURU; TOYOSHIMA MAYA; KAKEYA HIDEAKI; OSADA HIROYUKI; HAYASHI YUJIRO

  日本化学会講演予稿集, 13 Mar. 2006

  
• 理研天然化合物バンクの構築とスクリーニングへの利用

  SAITO TAKAO; UEKI MASASHI; SHIMIZU SHIRO; USUI TAKEO; KANO NAOKI; KONNO HIDEAKI; KAKEYA HIDEAKI; TOMIKI TSUYOSHI; OSADA HIROYUKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2006

  
• 糸状菌が生産する新規血管新生抑制剤asperamide AおよびBに関する研究

  KAKEYA HIDEAKI; ONOSE RIE; MAEDA TAKESHI; MAEDA TAKESHI; USAMI NORI; OSADA HIROYUKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2006

  
• インターロイキン‐1β変換酵素阻害剤EI‐1941‐1,‐2,‐3の効率的不斉全合成および構造活性相関研究

  SHOJI MITSURU; UNO TAKAO; KAKEYA HIDEAKI; ONOSE TOSHIE; OSADA HIROYUKI; HAYASHI YUJIRO

  有機合成シンポジウム講演要旨集, 25 Oct. 2005

  
• 抗腫瘍活性を有するlucilactaeneの不斉全合成及び生合成に関する考察

  YAMAGUCHI JUN'ICHIRO; KAKEYA HIDEAKI; SHOJI MITSURU; OSADA HIROYUKI; HAYASHI YUJIRO

  天然有機化合物討論会講演要旨集, 15 Sep. 2005

  
• インターロイキン‐1β変換酵素阻害剤EI‐1941‐1,EI‐1941‐2およびEI‐1941‐3の不斉全合成と構造活性相関研究

  SHOJI MITSURU; UNO TAKAO; HAYASHI YUJIRO; KAKEYA HIDEAKI; ONOSE RIE; OSADA HIROYUKI

  天然有機化合物討論会講演要旨集, 15 Sep. 2005

  
• P-43 Total Synthesis of EI-1941-1, EI-1941-2, and EI-1941-3 and The Biological Properties of Their Derivatives

  Shoji Mitsuru; Uno Takao; Hayashi Yujiro; Kakeya Hideaki; Onose Rie; Osada Hiroyuki

  Symposium on the Chemistry of Natural Products, symposium papers, 15 Sep. 2005

  
• 5 The Asymmetric Total Synthesis of Lucilactaene, a Cell Cycle Inhibitor in p53-Transfected Cancer Cells

  Yamaguchi Junichiro; Kakeya Hideaki; Shoji Mitsuru; Osada Hiroyuki; Hayashi Yujiro

  Symposium on the Chemistry of Natural Products, symposium papers, 15 Sep. 2005

  
• CytoxazoneによるTGF‐βシグナル伝達抑制を介する肝疾患の制御

  KONDO WAKIKO; KAKETANI HIDEAKI; WATABE TETSURO; KAWADA NORIFUMI; OKUNO MASATAKA; MORIWAKI HISATAKA; MIYAZONO KOHEI; OSADA HIROYUKI; KOJIMA TOSHIKAZU

  肝臓, 25 May 2005

  
• Total Syntheses of Fumagillin, RK-805 and FR65814 Using Proline Catalyzed Asymmetric .ALPHA.-Aminoxylation

  YAMAGUCHI JUN'ICHIRO; SHOJI MITSURU; KAKEYA HIDEAKI; OSADA HIROYUKI; HAYASHI YUJIRO

  日本化学会講演予稿集, 11 Mar. 2005

  
• Synthesis of epoxyquinols via the oxidative dimerization

  SHOJI MITSURU; IMAI HIROKI; KAKEYA HIDEAKI; OSADA HIROYUKI; HAYASHI YUJIRO

  日本化学会講演予稿集, 11 Mar. 2005

  
• Asymmetric Total Synthesis of lucilactaene

  YAMAGUCHI JUN'ICHIRO; KAKEYA HIDEAKI; UNO TAKAO; SHOJI MITSURU; OSADA HIROYUKI; HAYASHI YUJIRO

  日本化学会講演予稿集, 11 Mar. 2005

  
• Asymmetric total synthesis of synerazol

  HAYASHI YUJIRO; MUKAIYAMA TAKASUKE; GOTO HIROAKI; YONEHARA SAYAKA; SHOJI MITSURU; KAKEYA HIDEAKI; OSADA HIROYUKI

  日本化学会講演予稿集, 11 Mar. 2005

  
• 新規エポキシシクロヘキセノン誘導体RKTS‐33は,CTLによるFasリガンド依存性アポトーシスを特異的に阻害する

  MITSUI TOMOKAZU; MIYAKE YASUNOBU; KAKETANI HIDEAKI; HAYASHI YUJIRO; OSADA HIROYUKI; KATAOKA TAKAO

  日本農芸化学会大会講演要旨集, 05 Mar. 2005

  
• 糸状菌が生産する新規血管新生阻害物質 epoxytwinol Aに関する研究

  KAKEYA HIDEAKI; ONOSE TOSHIE; KOSHINO HIROYUKI; NAGATA HIROYUKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2005

  
• TGF‐β活性化反応ならびにシグナル伝達を標的とした肝再生の制御

  KONDO WAKAKO; KAKEYA HIDEAKI; SAIO MASANAO; OMI SHINOBU; MIYAZONO KOHEI; OSADA HIROYUKI; OKUNO MASATAKA; KOJIMA SOICHI

  日本分子生物学会年会プログラム・講演要旨集, 25 Nov. 2004

  
• 98(P-30) Total Syntheses of Fumagillin, RK-805 and FR65814 Using Proline Catalyzed Asymmetric α-Aminoxylation

  Yamaguchi Junichiro; Sumiya Tatsunobu; Hibino Kazuhiro; Shoji Mitsuru; Kakeya Hideaki; Osada Hiroyuki; Hayashi Yujiro

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Oct. 2004

  
• 55(P-29) Different Reaction Modes for the Oxidative Dimerization of Epoxyquinols and Epoxyquinones

  Shoji Mitsuru; Imai Hiroki; Hayashi Yujiro; Shiina Isamu; Kakeya Hideaki; Osada Hiroyuki

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Oct. 2004

  
• プロリンを用いた不斉触媒α‐アミノオキシ化反応を鍵反応とするfumagillin,RK‐805,FR65814の効率的全合成

  YAMAGUCHI JUN'ICHIRO; SUMIYA TATSUNOBU; HIBINO KAZUHIRO; SHOJI MITSURU; KAKEYA HIDEAKI; OSADA HIROYUKI; HAYASHI YUJIRO

  天然有機化合物討論会講演要旨集, 01 Sep. 2004

  
• 血管新生阻害剤Epoxyquinol A,Bの酸化的二量化反応に関する研究

  SHOJI MITSURU; IMAI HIROKI; HAYASHI YUJIRO; SHIINA ISAMU; KAKEYA HIDEAKI; OSADA HIROYUKI

  天然有機化合物討論会講演要旨集, 01 Sep. 2004

  
• Azaspireneの血管新生阻害効果

  OSADA HIROYUKI; ASAMI YUKIHIRO; KOMI YUSUKE; KOJIMA SOICHI; MIYAZAKI OSAMU; NISHIKAWA KIYOHIRO; KAKEYA HIDEAKI

  日本癌学会総会記事, 25 Aug. 2004

  
• 核酸系抗癌剤phosmidosineはプロリルtRNA合成酵素(ProRS)活性を阻害する

  KAKEYA HIDEAKI; OSADA HIROYUKI; ONOSE TOSHIE; SHIBUYA MASATAKA; OKADA KAZUHISA; KIYOO YASUSHI; SEKINE MITSUO

  日本癌学会総会記事, 25 Aug. 2004

  
• 新規血管新生阻害剤azaspireneによるMAPキナーゼカスケードの阻害

  ASAMI YUKIHIRO; KAKEYA HIDEAKI; OSADA HIROYUKI

  日本癌学会総会記事, 25 Aug. 2004

  
• Different reaction modes for the oxidative dimerization of epoxyquinols and epoxyquinones

  SHOJI MITSURU; SHIINA ISAMU; KAKEYA HIDEAKI; OSADA HIROYUKI; HAYASHI YUJIRO

  日本化学会講演予稿集, 11 Mar. 2004

  
• Asymmetric Total Synthesis of Lucilactaene

  HAYASHI YUJIRO; YAMAGUCHI JUN'ICHIRO; UNO TAKAO; SHOJI MITSURU; KAKEYA HIDEAKI; OSADA HIROYUKI

  日本化学会講演予稿集, 11 Mar. 2004

  
• Structure-Activity Relationship of Epolactaene Derivatives

  NAGUMO YOKO; KAKEYA HIDEAKI; SHOJI MITSURU; HAYASHI YUJIRO; OSADA HIROYUKI

  日本化学会講演予稿集, 11 Mar. 2004

  
• Asymmetric total synthesis of synerazol

  HAYASHI YUJIRO; SHOJI MITSURU; MUKAIYAMA TAKASUKE; YAMAGUCHI SHIMPEI; GOTO HIROAKI; KAKEYA HIDEAKI; OSADA HIROYUKI

  日本化学会講演予稿集, 11 Mar. 2004

  
• Novel synthetic methodology of heterocyclic compounds via Diels-Alder reaction of 2H-pyran derivatives.

  SHOJI MITSURU; IMAI HIROKI; KAKEYA HIDEAKI; OSADA HIROYUKI; HAYASHI YUJIRO

  日本化学会講演予稿集, 11 Mar. 2004

  
• エポキシシクロヘキセノン誘導体ECHは,CTLによるFasリガンド依存性アポトーシスを特異的に阻害する

  MITSUI TOMOKAZU; MIYAKE YASUNOBU; KAKEYA HIDEAKI; OSADA HIROYUKI; KATAOKA TAKAO

  日本分子生物学会年会プログラム・講演要旨集, 25 Nov. 2003

  
• 肝星細胞におけるサイトキサゾンによるTGF‐βシグナル伝達の抑制

  KONDO WAKAKO; KAKEYA HIDEAKI; KAWASAKI YASUO; KAWADA NORIFUMI; SAKAMOTO YASUHARU; NAKATA TADASHI; OSADA HIROYUKI; KOJIMA SOICHI

  日本分子生物学会年会プログラム・講演要旨集, 25 Nov. 2003

  
• 新規血管新生阻害剤azaspireneの全合成

  SHOJI MITSURU; YAMAGUCHI SHIMPEI; MUKAIYAMA TAKASUKE; GOTO HIROAKI; YAMAGUCHI JUN'ICHIRO; ASAMI YUKIHIRO; KAKEYA HIDEAKI; OSADA HIROYUKI; HAYASHI YUJIRO

  天然有機化合物討論会講演要旨集, 01 Sep. 2003

  
• 14 Total synthesis of azaspirene, a novel angiogenesis inhibitor

  Shoji Mitsuru; Yamaguchi Shinpei; Mukaiyama Takasuke; Goto Hiroaki; Yamaguchi Junichiro; Asami Yukihiro; Kakeya Hideaki; Osada Hiroyuki; Hayashi Yujiro

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Sep. 2003

  
• G1期特異的阻害剤phosmidosineの構造活性相関に関する研究

  KAKEYA HIDEAKI; OKADA KAZUHISA; ONOSE TOSHIE; SHIBUYA MASATAKA; KIYOO YASUSHI; SEKINE MITSUO; OSADA HIROHISA

  日本農芸化学会大会講演要旨集, 05 Mar. 2003

  
• 新規血管新生阻害剤RK‐95113の単離・構造解析および生物活性

  ASAMI YUKIHIRO; KAKEYA HIDEAKI; ONOSE TOSHIE; OTAGA GEN; TOI MASAKAZU; CHANG Y-H; OSADA HIROYUKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2003

  
• A Practical Total Synthesis of Epoxyquinols A and B

  SHOJI MITSURU; KISHIDA SATOSHI; TAKEDA MITSUHIRO; KAKEYA HIDEAKI; OSADA HIROYUKI; HAYASHI YUJIRO

  日本化学会講演予稿集, 03 Mar. 2003

  
• Studies on Dimerization of Epoxycyclohexenol Derivatives

  SHOJI MITSURU; KISHIDA SATOSHI; KAKEYA HIDEAKI; OSADA HIROYUKI; HAYASHI YUJIRO

  日本化学会講演予稿集, 03 Mar. 2003

  
• Asymmetric total synthesis of azaspirene and pseurotin A (1)

  HAYASHI YUJIRO; SHOJI MITSURU; YAMAGUCHI SHIMPEI; MUKAIYAMA TAKASUKE; YAMAGUCHI JUN'ICHIRO; KAKEYA HIDEAKI; OSADA HIROYUKI

  日本化学会講演予稿集, 03 Mar. 2003

  
• Total Synthesis of Lucilactaene

  HAYASHI YUJIRO; YAMAGUCHI JUN'ICHIRO; UNO TAKAO; SHOJI MITSURU; KAKEYA HIDEAKI; OSADA HIROYUKI

  日本化学会講演予稿集, 03 Mar. 2003

  
• Total Synthesis of Epoxyquinols A and B

  SHOJI MITSURU; YAMAGUCHI JUN'ICHIRO; KAKEYA HIDEAKI; OSADA HIROYUKI; HAYASHI YUJIRO

  日本化学会講演予稿集, 03 Mar. 2003

  
• Asymmetric total synthesis of azaspirene and pseurotin A (3)

  HAYASHI YUJIRO; SHOJI MITSURU; YAMAGUCHI JUN'ICHIRO; YAMAGUCHI SHIMPEI; MUKAIYAMA TAKASUKE; KAKEYA HIDEAKI; OSADA HIROYUKI

  日本化学会講演予稿集, 03 Mar. 2003

  
• Asymmetric total synthesis of azaspirene and pseurotin A (2)

  HAYASHI YUJIRO; SHOJI MITSURU; MUKAIYAMA TAKASUKE; YAMAGUCHI SHIMPEI; YAMAGUCHI JUN'ICHIRO; KAKEYA HIDEAKI; OSADA HIROYUKI

  日本化学会講演予稿集, 03 Mar. 2003

  
• 糸状菌が生産する新規血管新生阻害剤epoxyquinols AおよびBに関する研究

  KAKEYA HIDEAKI; ONOSE RIE; YOSHIDA ARIKA; KOSHINO HIROYUKI; KOBAYASHI KIMIKO; OSADA HIROYUKI

  天然有機化合物討論会講演要旨集, 01 Sep. 2002

  
• 新規血管新生阻害剤Epoxyquinol Aの全合成

  SHOJI MITSURU; YAMAGUCHI JUN'ICHIRO; KISHIDA SATOSHI; TAKEDA MITSUHIRO; KAKEYA HIDEAKI; OSADA HIROYUKI; HAYASHI YUJIRO

  天然有機化合物討論会講演要旨集, 01 Sep. 2002

  
• 35 Epoxyquinols A and B, Novel Angiogenesis Inhibitors Produced by a Fungus

  Kakeya Hideaki; Onose Rie; Yoshida Arika; Koshino Hiroyuki; Kobayashi Kimiko; Osada Hiroyuki

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Sep. 2002

  
• 3 Total Synthesis of Epoxyquinol A

  Shoji Mitsuru; Yamaguchi Junichiro; Kishida Satoshi; Takeda Mitsuhiro; Kakeya Hideaki; Osada Hiroyuki; Hayashi Yujiro

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Sep. 2002

  
• 血管内皮増殖因子(VGEF)の機能を標的とした新規血管新生阻害剤の探索研究

  KAKEYA HIDEAKI; ASAMI YUKIHIRO; OSADA HIROYUKI

  日本癌学会総会記事, 25 Aug. 2002

  
• 血管内皮細胞選択的増殖抑制活性を有する新規fumagillin類縁化合物に関する研究

  ASAMI YUKIHIRO; KAKEYA HIDEAKI; TOI MASAKAZU; CHANG Y-H; OSADA HIROYUKI

  日本癌学会総会記事, 25 Aug. 2002

  
• Structure and Biological Activity of Novel Angiogenesis Inhibitors Isolated from Microorganisms.

  KAKEYA HIDEAKI; OSADA HIROYUKI

  日本化学会講演予稿集, 11 Mar. 2002

  
• RK‐302によるレセプター依存性アポトーシスに対する選択的抑制作用の解析

  MIYAKE YASUNOBU; KAKETANI HIDEAKI; KATAOKA TAKAO; OSADA HIROYUKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2002

  
• 細胞の生死を制御する天然有機化合物を利用した化学生物学的研究

  KAKETANI HIDEAKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2002

  
• 構造活性相関に基づいたアポトーシス誘導物質サイトトリエニンAのプローブ合成

  KANO NAOKI; KAKETANI HIDEAKI; OSADA HIROYUKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2002

  
• 新規血管新生阻害剤azaspireneに関する研究

  ASAMI HIROYUKI; KAKETANI HIDEAKI; ONOSE TOSHIE; YOSHIDA YUKA; OSADA HIROYUKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2002

  
• 新規血管新生阻害剤asperamide ACに関する研究

  KAKETANI HIDEAKI; SEKIYA AKIMITSU; ONOSE TOSHIE; YOSHIDA YUKA; USAMI SATOSHI; HORIE HIROKI; OSADA HIROYUKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2002

  
• 新規血管新生阻害剤epoxyquinol Aに関する研究

  KAKETANI HIDEAKI; ONOSE TOSHIE; YOSHIDA YUKA; KOSHINO HIROYUKI; KOBAYASHI KIMIKO; KAGEYAMA SHUN'ICHIRO; OSADA HIROYUKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2002

  
• 新規血管新生阻害剤RK‐9756Aに関する研究

  KAKETANI HIDEAKI; YOSHIDA YUKA; KO H-R; ONOSE TOSHIE; UEKI MASASHI; MUROI MAKOTO; TAKATSUKI AKIRA; MATSUZAKI HIROSHI; OSADA HIROYUKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2002

  
• 新規血管新生阻害剤の探索研究

  KAKETANI HIDEAKI; ASAMI YUKIHIRO; ONOSE TOSHIE; DOI MASAKAZU; CHANG Y-H; OSADA HIROYUKI

  日本農芸化学会大会講演要旨集, 05 Mar. 2002

  
• Lucilactaene, a new anticancer drug produced by Fusarium sp.

  KAKEYA HIDEAKI; KAGEYAMA SHUN'ICHIRO; LIN N; ONOSE RIE; OSADA HIROYUKI

  天然有機化合物討論会講演要旨集, 01 Sep. 2001

  
• 61(P-18) Lucilactaene, a new anticancer drug produced by Fusarium sp.

  Kakeya Hideaki; Kageyama Shun-Ichiro; Nie Lin; Onose Rie; Osada Hiroyuki

  Symposium on the Chemistry of Natural Products, symposium papers, 01 Sep. 2001

  
• 新規細胞周期阻害剤RK‐9794に関する研究

  KAKETANI HIDEAKI; KAGEYAMA SHUN'ICHIRO; NIE L; ONOSE TOSHIE; OKADA HAJIME; UEKI MASASHI; BEPPU TERUHIKO; NORBURY C; OSADA HIROYUKI

  日本農芸化学会誌, 05 Mar. 2001

  
• Activation of MST/Krs proteins during anticancer drugs-induced apoptosis

  OSADA Hiroyuki; WATABE Masahiko; KAKEYA Hideaki

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• Activation of MST/Krs proteins during anticancer drugs-induced apoptosis

  OSADA Hiroyuki; WATABE Masahiko; KAKEYA Hideaki

  日本分子生物学会年会プログラム・講演要旨集, 01 Dec. 1998

  
• 抗がん剤によるMST/Krsタンパク質の活性化とアポトーシス誘導

  OSADA HIROYUKI; WATABE MASAHIKO; KAKEYA HIDEAKI

  日本分子生物学会年会プログラム・講演要旨集, Nov. 1998

  
• 抗がん剤によるMST/Krsタンパク質の活性化とアポトーシス誘導

  OSADA HIROYUKI; WATABE MASAHIKO; KAKEYA HIDEAKI

  日本分子生物学会年会プログラム・講演要旨集, Nov. 1998

  
• Synthesis of Cytoxazone, a Novel Immunomodulator.

  SAKAMOTO YASUHARU; SHIRAISHI AKIKO; NAKATA TADASHI; KAKEYA HIDEAKI; OSADA HIROYUKI

  日本化学会講演予稿集, Mar. 1998

  
• 101(P45) Studies on Novel Apoptosis Inducer Cytotrienins

  Zhang H.-p; Kakeya H; Osada H

  Symposium on the Chemistry of Natural Products, symposium papers, 20 Jul. 1997

  
• Studies on Novel Apoptosis Inducer Cytotrienins

  ZHANG H-P; KAKEYA HIDEAKI; OSADA HIROYUKI

  天然有機化合物討論会講演要旨集, Jul. 1997

  
• 9 ISOLATION, STRUCTURE DETERMINATION AND BIOLOGICAL ACTIVITIES OF NOVEL MAMMALIAN CELL CYCLE INHIBITORS, SPIROTRYPROSTATINS A & B, TRYPROSTATINS A & B AND RELATED NEW DIKETOPIPERAZINE DERIVATIVES PRODUCED BY A FUNGUS, ASPERGILLUS FUMIGATUS

  Cui Cheng-Bin; Kakeya Hideaki; Osada Hiroyuki

  Symposium on the Chemistry of Natural Products, symposium papers, 02 Sep. 1996

  
• Isolation, Structure Determination and Biological Activities of Novel Mammalian Cell Cycle Inhibitors, Spirotryprostatins A&B, Tryprostatins A&B and Related New Diketopiperazine Derivatives Produced by a Fungus, Aspergillus fumigatus.

  CUI C-B; KAKEYA HIDEAKI; OSADA HIROYUKI

  天然有機化合物討論会講演要旨集, Sep. 1996

  
• 新規細胞周期阻害剤acetophthalidinの構造、性質と活性 : 有機化学・天然物化学

  崔 承彬; 生方 信; 掛谷 秀昭; 長田 裕之

  日本農藝化學會誌, 05 Mar. 1996

  
• 新規細胞周期阻害剤typorostatin AおよびBの構造と活性 : 有機化学・天然物化学

  崔 承彬; 生方 信; 掛谷 秀昭; 長田 裕之

  日本農藝化學會誌, 05 Mar. 1996

  
• 神経細胞分化誘導剤エポラクタエン類縁化合物の生物活性 : 有機化学・天然物化学

  掛谷 秀昭; 小野澤 千津子; 佐藤 正和; 新井 好史; 長田 裕之

  日本農藝化學會誌, 05 Mar. 1996

  
• 神経突起伸張作用を有する新規化合物エポラクタエンの単離精製 : 有機化学・天然物化学

  掛谷 秀昭; 小野瀬 利恵; 小日向 君江; 岡田 元; 高橋 勇; 磯野 清; 長田 裕之

  日本農藝化學會誌, 05 Jul. 1995

  
• 新規細胞増殖調節物質Sparoxomycin A1, A2 : 有機化学・天然物化学

  生方 信; 森田 徹一郎; 掛谷 秀昭; 小日向 君江; 工藤 卓二; 浦本 昌和; 長田 裕之

  日本農藝化學會誌, 05 Jul. 1995

  
• 微生物によるB‐置換グルタロニトリルのエナンチオ選択的加水分解

  掛谷秀昭; 酒井直子; 佐野明男; 横山雅裕; 須具威; 太田博道

  日本化学会講演予稿集, Mar. 1992

  
• 75 SYNTHESIS OF OPTICALLY ACTIVE NATURAL PRODUCTS BY THE AID OF LIPASES

  Sugai T; Kakeya H; Yamada H; Matsumoto K; Ohsawa S; Suzuki N; Ohta H

  Symposium on the Chemistry of Natural Products, symposium papers, 25 Sep. 1990

  
• 生体触媒を利用する光学活性フロンタリンの合成

  須貝威; 掛谷秀昭; 木村陽一; 太田博道

  日本化学会講演予稿集, Sep. 1990

  
• 生物化学的手法を利用した光学活性アブシジン酸類縁化合物の合成

  掛谷秀昭; 須貝威; 太田博道

  日本化学会講演予稿集, Sep. 1990

  
• Synthesis of optically active natural products by the aid of lipases.

  須貝威; 掛谷秀昭; 山田泰; 松本一嗣; 大沢祥子; 鈴木奈津子; 太田博道

  天然有機化合物討論会講演要旨集, Sep. 1990

  

Books and Other Publications

• 「くすりをつくる研究者の仕事―薬のタネ探しから私たちに届くまで」

  掛谷 秀昭, Contributor, 創薬ケミカルバイオロジー：自然に学ぶ薬づくり

  化学同人, 2017, Not refereed

  
• Newton 別冊 「くすりの科学知識：くすりのしくみと、奥深き創薬の世界」

  掛谷 秀昭, Supervisor, 1. 薬の基礎知識 & 2. 創薬の世界

  ニュートンプレス社, 2017, Not refereed

  
• Newton 別冊 「驚異のバクテリア：バクテリア＝細菌の生態と可能性」

  掛谷 秀昭, Others, プロローグ「大村智博士ノーベル賞受賞」

  ニュートンプレス社, 2016, Not refereed

  
• Newton Special 「知られざる創薬の世界：夢のくすりを求めて」

  掛谷 秀昭, Supervisor

  ニュトンプレス社, Jul. 2015, Not refereed

  

Industrial Property Rights

• 特開2020-180052, 特願2019-081766, 新規フルオロジニトロフェニル化合物及びその用途

  掛谷 秀昭; 倉永 健史; 小川 はるか

  
• 特許第6270547号, 特開2015-166329, 特願2014-041703, 新規生物活性物質

  掛谷 秀昭; 西村 慎一; 服部 明; 岸本 真治; 波多野 和樹; 五十嵐 雅之

  
• WO2018-003857, WO2018-003857, JP2017023753, 非経口投与用医薬組成物

  掛谷 秀昭; 金井 雅史; 高橋 伸明; 橋本 正; 今泉 厚; 小澤 瞳

  
• 特許第5846527号, 特願2012-500649, TGF-βシグナル伝達阻害剤

  掛谷 秀昭; 服部 明; 高須 康明; 藤井 信孝; 大石 真也; 小嶋 聡一; 原 詳子

  
• 特開2015-166329, 特願2014-041703, 新規生物活性物質

  掛谷 秀昭; 西村 慎一; 服部 明; 岸本 真治; 波多野 和樹; 五十嵐 雅之

  
• 特開2014-097954, 特願2012-250490, 3β-ヒドロキシステロイドデヒドロゲナーゼ阻害剤

  掛谷 秀昭; 酒井 佑宜; 服部 明; 西村 慎一; 岡村 均; 土居 雅夫

  
• 特開2014-028780, 特願2012-170361, 新規抗真菌剤

  掛谷 秀昭; 西村 慎一; 杉山 龍介; 尾仲 宏康

  
• 特許第4870276号, 特開2002-322149, 特願2001-127575, アポトーシス抑制作用を有するRKB-3384物質

  長田 裕之; 掛谷 秀昭; 今野 宏; 金澤 進

  
• 特許第4833461号, 特開2003-096078, 特願2001-293936, 新規血管新生阻害剤

  長田 裕之; 掛谷 秀昭; 今野 宏; 金澤 進

  
• 特許第4808853号, 特開2002-226483, 特願2001-025030, 新規抗腫瘍剤

  長田 裕之; 掛谷 秀昭; 植木 雅志

  
• WO2011-102436, WO2011-102436, JP2011053428, TGF-βシグナル伝達阻害剤

  掛谷 秀昭; 服部 明; 高須 康明; 藤井 信孝; 大石 真也; 小嶋 聡一; 原 詳子

  
• 特許第4688680号, 特願2005-515065, TGF-β情報伝達経路阻害剤

  小嶋 聡一; 近藤 和嘉子; 掛谷 秀昭; 長田 裕之; 坂本 康治; 中田 忠

  
• 特許第4624260号, 特願2005-506199, 新規3置換ベンゼン誘導体、その製造方法、およびそれを含む医薬組成物

  長田 裕之; 掛谷 秀昭; 林 雄二郎; 庄司 満; 内田 さえこ

  
• 特許第4617136号, 特開2006-131504, 特願2004-318799, 新規化合物、これを含有する医薬及びこの製造方法

  林 雄二郎; 庄司 満; 長田 裕之; 掛谷 秀昭

  
• 特許第4523761号, 特開2004-059584, 特願2003-164126, 抗腫瘍活性を有する新規化合物、およびその製造方法

  長田 裕之; 掛谷 秀昭; 林 雄二郎

  
• 特許第4452787号, 特開2004-269456, 特願2003-065013, 新規発酵生産物

  長田 裕之; 掛谷 秀昭; 永井 浩二; 武田 靖代; 柴崎 充至

  
• 特開2009-191000, 特願2008-032312, 中間体化合物及びその製造方法、並びにアンサマイシン系抗生物質の製造方法

  林 雄二郎; 長田 裕之; 掛谷 秀昭

  
• 特開2009-073791, 特願2007-246182, 新規生理活性物質RKGS-A2215A

  長田 裕之; 掛谷 秀昭; 森 美穂子; 根岸 恵則

  
• 特開2007-238506, 特願2006-063522, 新規化合物及びその製造方法

  林 雄二郎; 庄司 満; 長田 裕之; 掛谷 秀昭

  
• 特許第3990477号, 特開平9-323928, 特願平9-046824, 神経分化誘導剤

  新井 好史; 佐藤 正和; 掛谷 秀昭; 長田 裕之

  
• 特許第3942422号, 特開2003-183205, 特願2001-382539, 抗腫瘍・抗炎症作用を有する新規物質

  長田 裕之; 掛谷 秀昭; 今野 宏; 金澤 進

  
• 特許第3913542号, 特開2003-183249, 特願2001-382537, 血管新生阻害作用を有する新規物質

  長田 裕之; 掛谷 秀昭; 今野 宏; 金澤 進

  
• 特開2006-321759, 特願2005-147097, Vprタンパク質機能の阻害剤及びこれを含有するエイズ治療薬

  長田 裕之; 渡辺 信元; 掛谷 秀昭; 三好 浩之; 山口 智之

  
• 特開2006-131504, 特願2004-318799, 新規化合物、これを含有する医薬及びこの製造方法

  林 雄二郎; 庄司 満; 長田 裕之; 掛谷 秀昭

  
• 特開2006-052177, 特願2004-235468, 光学活性ジエポキシド、これを含有する医薬及びこの製造方法

  林 雄二郎; 庄司 満; 長田 裕之; 掛谷 秀昭

  
• 特許第3753285号, 特開平11-209355, 特願平10-014152, サイトキサゾン、その製造方法、免疫調節剤、及び抗癌剤

  長田 裕之; 掛谷 秀昭; 小日向 君江

  
• 特許第3726996号, 特開2000-086639, 特願平10-260347, サイトキサゾンの合成方法

  坂本 康治; 中田 忠; 長田 裕之; 掛谷 秀昭

  
• 特許第3726980号, 特開平10-158245, 特願平8-320241, サイトトリエニン類、その製造方法および抗腫瘍剤

  長田 裕之; 掛谷 秀昭; 張 恵平; 小日向 君江

  
• 特許第3719689号, 特開平9-059275, 特願平7-214659, 新規物質トリプロスタチン、その製造方法、細胞周期阻害剤および抗腫瘍剤

  長田 裕之; 掛谷 秀昭; 崔 承彬; 磯野 清; 高橋 勇

  
• 特許第3683003号, 特開平8-269061, 特願平7-069255, 抗腫瘍性物質エポラクタエン

  長田 裕之; 掛谷 秀昭; 磯野 清; 高橋 勇

  
• WO2005-039570, WO2005-039570, JP2004016370, TGF-β情報伝達経路阻害剤

  小嶋 聡一; 近藤 和嘉子; 掛谷 秀昭; 長田 裕之; 坂本 康治; 中田 忠

  
• WO2004-101483, WO2004-101483, JP2004006546, 新規3置換ベンゼン誘導体、その製造方法、およびそれを含む医薬組成物

  長田 裕之; 掛谷 秀昭; 林 雄二郎; 庄司 満; 内田 さえこ

  
• 特開2004-315373, 特願2003-107647, 抗腫瘍活性および血管新生阻害活性を有する化合物、ならびにその製造方法

  長田 裕之; 掛谷 秀昭; 林 雄二郎; 庄司 満

  
• 特開2004-307420, 特願2003-105362, 細胞死抑制作用を有する化合物、およびその製造方法

  長田 裕之; 掛谷 秀昭; 林 雄二郎; 庄司 満

  
• 特開2004-269456, 特願2003-065013, 新規発酵生産物

  長田 裕之; 掛谷 秀昭; 永井 浩二; 武田 靖代; 柴崎 充至

  
• 特開2004-262881, 特願2003-056628, 血管新生阻害作用を有する化合物、その製造方法、及び医薬組成物

  長田 裕之; 掛谷 秀昭

  
• 特開2004-059584, 特願2003-164126, 抗腫瘍活性を有する新規化合物、およびその製造方法

  長田 裕之; 掛谷 秀昭; 林 雄二郎

  
• 特開2004-000130, 特願2002-348760, ゼアラレノン解毒酵素遺伝子及び該遺伝子を導入した形質転換体

  山口 勇; 木村 真; 安藤 直子; 西山 亜里砂; 福田 徹子; 掛谷 秀昭; 長田 裕之

  
• 特開2003-183205, 特願2001-382539, 抗腫瘍・抗炎症作用を有する新規物質

  長田 裕之; 掛谷 秀昭; 今野 宏; 金澤 進

  
• 特開2003-183249, 特願2001-382537, 血管新生阻害作用を有する新規物質

  長田 裕之; 掛谷 秀昭; 今野 宏; 金澤 進

  
• 特開2003-096078, 特願2001-293936, 新規血管新生阻害剤

  長田 裕之; 掛谷 秀昭; 今野 宏; 金澤 進

  
• 特開2003-026696, 特願2001-216505, 新規血管新生阻害剤

  長田 裕之; 掛谷 秀昭

  
• 特開2002-322182, 特願2001-127576, 血管新生阻害作用を有するRKB-3564物質

  長田 裕之; 掛谷 秀昭; 今野 宏; 金澤 進

  
• 特開2002-322149, 特願2001-127575, アポトーシス抑制作用を有するRKB-3384物質

  長田 裕之; 掛谷 秀昭; 今野 宏; 金澤 進

  
• 特開2002-226483, 特願2001-025030, 新規抗腫瘍剤

  長田 裕之; 掛谷 秀昭; 植木 雅志

  
• 特開2000-086639, 特願平10-260347, サイトキサゾンの合成方法

  坂本 康治; 中田 忠; 長田 裕之; 掛谷 秀昭

  
• 特開平11-209355, 特願平10-014152, サイトキサゾン、その製造方法、免疫調節剤、及び抗癌剤

  長田 裕之; 掛谷 秀昭; 小日向 君江

  
• 特開平10-237043, 特願平9-040543, RKS-1778、その製造方法、細胞周期阻害剤および抗腫瘍剤

  長田 裕之; 掛谷 秀昭; 吉浜 誠; 木村 賢一

  
• 特開平10-158245, 特願平8-320241, サイトトリエニン類、その製造方法および抗腫瘍剤

  長田 裕之; 掛谷 秀昭; 張 恵平; 小日向 君江

  
• 特開平9-323928, 特願平9-046824, 神経分化誘導剤

  新井 好史; 佐藤 正和; 掛谷 秀昭; 長田 裕之

  
• 特開平9-255680, 特願平8-070071, スピロトリプロスタチン、その製造法、細胞周期阻害剤および抗腫瘍剤

  長田 裕之; 崔 承彬; 掛谷 秀昭; 磯野 清; 山下 富美男

  
• 特開平9-087269, 特願平7-249244, アセトフタリジン、細胞周期阻害剤および抗腫瘍剤

  長田 裕之; 崔 承彬; 掛谷 秀昭; 磯野 清; 高橋 勇

  
• 特開平9-059275, 特願平7-214659, 新規物質トリプロスタチン、その製造方法、細胞周期阻害剤および抗腫瘍剤

  長田 裕之; 掛谷 秀昭; 崔 承彬; 磯野 清; 高橋 勇

  
• 特開平8-269061, 特願平7-069255, 抗腫瘍性物質エポラクタエン

  長田 裕之; 掛谷 秀昭; 磯野 清; 高橋 勇

  

Awards

• 1999

  The Japanese Association for Molecular Target Therapy of Cancer, Young Investigators Awards of the Japanese Association for Molecular Target Therapy of Cancer
• 2002

  Japan Society for Bioscience, Biotechnology, and Agrochemistry, Research Promotion Award, Japan Society for Bioscience, Biotechnology, and Agrochemistry
• 2006

  Japan Antibiotics Research Association, The Sumiki Umezawa Memorial Awards
• 2006

  Faculty of Science and Technology, Keio University, The Awards, Alumni Association of Faculty of Science and Technology, Keio University
• 2007

  Keimei Foundation, The Keimei Life Science Prize
• 2013

  Osaka Pref., Bio Advancing Knowledge Award, Bio Business Award Japan 2013
• 18 Jun. 2016

  Kobayashi Foundation for Cancer Research, Japan, The 1st. Kobayashi Foundation Award for Cancer Research

External funds: Kakenhi