Basic Information

Faculty

• Faculty of Engineering

Concurrent Affiliation

• Institute for Advanced Study, 物質－細胞統合システム拠点, 連携主任研究者

Professional Memberships

• American Chemical Society
• Royal Society of Chemistry
• 分析化学会
• 高分子学会
• 日本化学会

Academic Degree

• 工学修士(京都大学)
• 工学博士(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院工学研究科合成化学専攻博士課程, 修了
• 京都大学, 大学院工学研究科合成化学専攻修士課程, 修了

Academic Resume (Undergraduate School/Majors)

• 京都大学, 工学部合成化学科, 卒業

Research History

• From 2001, To 2005

  Kyushu University, Professor
• From 2005, To Present

  Kyoto University, Professor
• From 1999, To 2001

  Institute for Molecular Science, Visiting Associate Professor
• From 1992, To 2001

  Kyushu University, associate Professor
• From 1988, To 1992

  Kyushu University, assistant Professor

Language of Instruction

• English

ID,URL

• ORCID ID

  0000-0002-3327-3916

• J-Global ID

  200901065097141919

• External link

  http://www.sbchem.kyoto-u.ac.jp/hamachi-lab/

researchmap URL

• https://researchmap.jp/read0172097

Research

Research Topics, Overview of the research

• Research Topics

  Live-cell Organic Chemistry

• Overview of the research

  The objective is development of original chemistry-based strategies and methods which can be applied to study live cells and living systems in molecular/atomic details.

Research Interests

• 超分子化学
• 化学生物学
• 生物有機化学
• supramolecular chemistry
• chemical biology
• bioorganic chemistry

Research Areas

• Nanotechnology/Materials, Polymer chemistry
• Nanotechnology/Materials, Synthetic organic chemistry
• Nanotechnology/Materials, Molecular biochemistry

Papers

• Profiling Proteins Involved in Peroxynitrite Homeostasis Using ROS/RNS Conditional Proteomics

  Hao Zhu; Hiroaki Uno; Kyoichi Matsuba; Itaru Hamachi

  Journal of the American Chemical Society, 05 Mar. 2025

  
• Chromosomal domain formation by archaeal SMC, a roadblock protein, and DNA structure

  Kodai Yamaura; Naomichi Takemata; Masashi Kariya; Ayami Osaka; Sonoko Ishino; Masataka Yamauchi; Tomonori Tamura; Itaru Hamachi; Shoji Takada; Yoshizumi Ishino; Haruyuki Atomi

  Nature Communications, 19 Feb. 2025

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• A Protein Cleavage Platform Based on Selective Formylation at Cysteine Residues

  Naoki Zenmyo; Yuya Matsumoto; Akihiro Yasuda; Shohei Uchinomiya; Naoya Shindo; Kaori Sasaki-Tabata; Emi Mishiro-Sato; Tomonori Tamura; Itaru Hamachi; Akio Ojida

  Journal of the American Chemical Society, 29 Jan. 2025

  
• Targeted Covalent Modification Strategies for Drugging the Undruggable Targets

  Tomonori Tamura; Masaharu Kawano; Itaru Hamachi

  Chemical Reviews, 22 Jan. 2025

  
• O-ClickFCを用いたホスファチジルコリン代謝動態のCRISPRスクリーニング

  Itaru Hamachi

  生化学, 25 Dec. 2024

  
• Conversion of silent synapses to AMPA receptor-mediated functional synapses in human cortical organoids

  Masatoshi Nishimura; Tomoki Kodera; Shota Adachi; Akinori Y. Sato; Ryosuke F. Takeuchi; Hiroshi Nonaka; Itaru Hamachi; Fumitaka Osakada

  Neuroscience Research, Mar. 2025

  
• N-Acyl-N-alkyl/aryl Sulfonamide Chemistry Assisted by Proximity for Modification and Covalent Inhibition of Endogenous Proteins in Living Systems

  Tomonori Tamura; Itaru Hamachi

  Accounts of Chemical Research, 07 Jan. 2025

  
• Naturally occurring quercetin and myricetin as potent inhibitors for human ectonucleotide pyrophosphatase/phosphodiesterase 1

  P Duangiad; B Nutho; T Chaijarasphong; NP Morales; T Pongtharangkul; I Hamachi; A Ojida; J Wongkongkatep

  SCIENTIFIC REPORTS, Jan. 2024, Peer-reviewed

  
• Chemical, Pharmacological, and Structural Characterization of Novel Acrylamide-Derived Modulators of the GABAA Receptor

  HR Arias; SR Pierce; AL Germann; SQ Xu; MO Ortells; S Sakamoto; D Manetti; MN Romanelli; I Hamachi; G Akk

  MOLECULAR PHARMACOLOGY, Sep. 2023, Peer-reviewed

  
• A fluorophore–ligand conjugate for the rapid and reversible staining of native AMPA receptors in living neurons

  Kyohei Soga; Takaaki Fujiwara; Mayu Nakagawa; Akihiro Shibata; Hansel Adriel; Kenji Yatsuzuka; Wataru Kakegawa; Michisuke Yuzaki; Itaru Hamachi; Eriko Nango; Shigeki Kiyonaka

  22 Aug. 2024

  
• In-brain construction of receptor-based protease sensors by coupling ligand-directed chemistry and click chemistry

  Seiji Sakamoto; Kazuki Shiraiwa; Mengchu Wang; Mamoru Ishikawa; Hiroshi Nonaka; Itaru Hamachi

  24 May 2024

  
• Emergence of Dynamic Instability by Hybridizing Synthetic Self-Assembled Dipeptide Fibers with Surfactant Micelles

  S Torigoe; K Nagao; R Kubota; I Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2024, Peer-reviewed

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• Cell‐Like Synthetic Supramolecular Soft Materials Realized in Multicomponent, Non‐/Out‐of‐Equilibrium Dynamic Systems

  Ryou Kubota; Itaru Hamachi

  Advanced Science, Feb. 2024

  
• Lysine-reactive N-acyl-N-aryl sulfonamide warheads: Improved reaction properties and application in the covalent inhibition of an ibrutinib-resistant BTK mutant

  M Kawano; S Murakawa; K Higashiguchi; K Matsuda; T Tamura; I Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 2023, Peer-reviewed

  
• Optochemical profiling of receptor-proximal proteins in vivo in minutes

  Itaru Hamachi; Mikiko Takato; Seiji Sakamoto; Hiroshi Nonaka; Tomonori Tamura

  14 Nov. 2023

  
• Phototriggered profiling of receptor-proximal proteins in vivo in minutes

  Mikiko Takato; Seiji Sakamoto; Hiroshi Nonaka; Tomonori Tamura; Itaru Hamachi

  25 May 2023

  
• P2Y12 receptor ligands enable design of fluorescent imaging probes for microglia

  Hiroshi Nonaka; Mengchu Wang; Itaru Hamachi

  Chemistry Letters, 04 Oct. 2024

  
• Protein-Labeling Reagents Selectively Activated by Copper(I).

  Rong Cheng; Yuki Nishikawa; Takumi Wagatsuma; Taiho Kambe; Yu-Ki Tanaka; Yasumitsu Ogra; Tomonori Tamura; Itaru Hamachi

  ACS chemical biology, 21 Jun. 2024

  
• Molecular anchoring and fluorescent labeling in animals compatible with tissue clearing for 3D imaging.

  Takeharu Mino; Hiroshi Nonaka; Itaru Hamachi

  Current opinion in chemical biology, Aug. 2024

  
• Photoproximity labeling of endogenous receptors in the live mouse brain in minutes.

  Mikiko Takato; Seiji Sakamoto; Hiroshi Nonaka; Fátima Yuri Tanimura Valor; Tomonori Tamura; Itaru Hamachi

  Nature chemical biology, 01 Aug. 2024

  
• Nanoscale organization is changed in native, surface AMPARs by mouse brain region and tauopathy.

  Rohit M Vaidya; Jiahao Zhang; Duncan Nall; Yongjae Lee; Eung Chang Kim; Donghan Ma; Fang Huang; Hiroshi Nonaka; Shigeki Kiyonaka; Itaru Hamachi; Hee Jung Chung; Paul R Selvin

  bioRxiv : the preprint server for biology, 23 Jul. 2024

  
• Development of the suplamolecular nano-fiber as a device for molecular recognition

  Shun-Ichi Tamaru; Itaru Hamachi

  Polymer Preprints, Japan, 2006

  
• Development of the suplamolecular gel fiber as a bio-device

  Shun-Ichi Tamaru; Itaru Hamachi

  Polymer Preprints, Japan, 2005

  
• Molecular technologies in life innovation: Novel molecular technologies for labeling and functional control of proteins under live cell conditions

  Itaru Hamachi; Shigeki Kiyonaka; Tomonori Tamura; Ryou Kubota

  Molecular Technology: Materials Innovation, 06 Feb. 2019

  
• A conditional proteomics approach to profile proteins under zinc-rich environments

  Tomonori Tamura; Itaru Hamachi

  Seikagaku, 2018

  
• Protocol to visualize the distribution of exogenously administered small molecules in the mouse brain

  Takeharu Mino; Hiroshi Nonaka; Seiji Sakamoto; Jae Hoon Oh; Itaru Hamachi

  STAR Protocols, Sep. 2023

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• Post-click labeling enables highly accurate single cell analyses of glucose uptake ex vivo and in vivo.

  Masaki Tsuchiya; Nobuhiko Tachibana; Itaru Hamachi

  Communications biology, 16 Apr. 2024

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• Flow cytometric analysis of phosphatidylcholine metabolism using organelle-selective click labeling.

  Masaki Tsuchiya; Nobuhiko Tachibana; Itaru Hamachi

  STAR protocols, 15 Sep. 2023

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• Tyrosinase-Based Proximity Labeling in Living Cells and In Vivo

  Hao Zhu; Jae Hoon Oh; Yuna Matsuda; Takeharu Mino; Mamoru Ishikawa; Hideki Nakamura; Muneo Tsujikawa; Hiroshi Nonaka; Itaru Hamachi

  Journal of the American Chemical Society, 06 Mar. 2024

  
• Bioorthogonal chemical labeling of endogenous neurotransmitter receptors in living mouse brains.

  Hiroshi Nonaka; Seiji Sakamoto; Kazuki Shiraiwa; Mamoru Ishikawa; Tomonori Tamura; Kyohei Okuno; Takumi Kondo; Shigeki Kiyonaka; Etsuo A Susaki; Chika Shimizu; Hiroki R Ueda; Wataru Kakegawa; Itaru Arai; Michisuke Yuzaki; Itaru Hamachi

  Proceedings of the National Academy of Sciences of the United States of America, 06 Feb. 2024

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• Coronaridine congeners induce sedative and anxiolytic-like activity in naive and stressed/anxious mice by allosteric mechanisms involving increased GABAA receptor affinity for GABA

  HR Arias; P De Deurwaerd; P Scholze; S Sakamoto; I Hamachi; G Di Giovanni; A Chagraoui

  EUROPEAN JOURNAL OF PHARMACOLOGY, Aug. 2023, Peer-reviewed

  
• Ligand-Directed Chemistry for Protein Labeling for Affinity-Based Protein Analysis

  S Sakamoto; I Hamachi

  ISRAEL JOURNAL OF CHEMISTRY, Mar. 2023, Peer-reviewed

  
• Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes

  野中 洋; 美野 丈晴; 坂本 清志; Jae Hoon Oh; 渡邉 侑; 石川 守; 對馬 暁洋; 天池 一真; 清中 茂樹; 田村 朋則; A. Radu Aricescu; 掛川 渉; 三浦 会里子; 柚崎 通介; 浜地 格

  Chem, Feb. 2023, Peer-reviewed

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• Modulation of the mammalian GABA(A) receptor by type I and type II positive allosteric modulators of the alpha 7 nicotinic acetylcholine receptor

  HR Arias; AL Germann; SR Pierce; S Sakamoto; MO Ortells; I Hamachi; G Akk

  BRITISH JOURNAL OF PHARMACOLOGY, Dec. 2022, Peer-reviewed

  
• Fluorescence identification of arthropathic calcium pyrophosphate single crystals using alizarin red S and a xanthene dipicolylamine ZnII complex

  Waralee Srinarawat; Ruedee Hemstapat; Tulyapruek Tawonsawatruk; Nisa Patikarnmonthon; Itaru Hamachi; Akio Ojida; Jirarut Wongkongkatep

  The Analyst, Oct. 2022, Peer-reviewed

  
• オルガネラ膜特異的なホスファチジルコリンのライブイメージング

  田村 朋則; 浜地 格

  実験医学, 2021

  
• 生体分子センシングや薬剤放出の多段階制御を可能とする超分子ヒドロゲル

  中村 圭佑; 窪田 亮; 浜地 格

  バイオサイエンスとインダストリー / バイオサイエンスとインダストリー編集委員会 編, 2021, Peer-reviewed

  
• Visualizing Formation and Dynamics of a Three-Dimensional Sponge-like Network of a Coacervate in Real Time

  Ryou Kubota; Taro Hiroi; Yuriki Ikuta; Yuchong Liu; Itaru Hamachi

  Journal of the American Chemical Society, 10 Aug. 2023

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• Four distinct network patterns of supramolecular/polymer composite hydrogels controlled by formation kinetics and interfiber interactions

  Keisuke Nakamura; Ryou Kubota; Takuma Aoyama; Kenji Urayama; Itaru Hamachi

  Nature Communications, 27 Mar. 2023

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• Temporal Stimulus Patterns Drive Differentiation of a Synthetic Dipeptide-Based Coacervate

  Ryou Kubota; Shogo Torigoe; Itaru Hamachi

  Journal of the American Chemical Society, 09 Aug. 2022

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• Endogenous Cell-Surface Receptor Modification by Metal Chelation-Assisted Pyridinium Oxime Catalyst

  Vikram Thimaradka; Hayata Utsunomiya; Tomonori Tamura; Itaru Hamachi

  Organic Letters, 22 Mar. 2023

  
• Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes

  Hiroshi Nonaka; Takeharu Mino; Seiji Sakamoto; Jae Hoon Oh; Yu Watanabe; Mamoru Ishikawa; Akihiro Tsushima; Kazuma Amaike; Shigeki Kiyonaka; Tomonori Tamura; A. Radu Aricescu; Wataru Kakegawa; Eriko Miura; Michisuke Yuzaki; Itaru Hamachi

  Chem, Feb. 2023

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• Chemical biology tools for imaging-based analysis of organelle membranes and lipids

  Tomonori Tamura; Itaru Hamachi

  Current Opinion in Chemical Biology, Oct. 2022

  
• Organelle‐Selective Labeling of Choline‐Containing Phospholipids (CPLs) and Real‐Time Imaging in Living Cells

  Masaki Tsuchiya; Tomonori Tamura; Itaru Hamachi

  Current Protocols, 22 Apr. 2021

  
• 敗血症の病態と治療 新たなる視点と展望 敗血症患者における器官特異的蛍光ATPプローブを用いたヒト好中球蛍光イメージング

  末吉 孝一郎; 角 由佳; 井上 貴昭; 石井 久美子; 中山 仁志; 岩渕 和久; 栗下 泰孝; 重光 孟; 浜地 格; 田中 裕

  日本救急医学会雑誌, Aug. 2014

  
• 2P-157 BIOMIMETIC FUNCTIONAL FIBROUS GEL CONSTRUCTED BY HIERARCHICAL SUPRAMOLECULAR ASSEMBLY OF ORGANIC MOLECULES(Cell biology,The 47th Annual Meeting of the Biophysical Society of Japan)

  Kiriya Daisuke; Onoe Hiroaki; Ikeda Masato; Hamachi Itaru; Takeuchi Shoji

  Seibutsu Butsuri, 2009

  
• Organelle-selective click labeling coupled with flow cytometry allows pooled CRISPR screening of genes involved in phosphatidylcholine metabolism.

  Masaki Tsuchiya; Nobuhiko Tachibana; Kohjiro Nagao; Tomonori Tamura; Itaru Hamachi

  Cell metabolism, 07 Mar. 2023

  
• On-cell coordination chemistry: Chemogenetic activation of membrane-bound glutamate receptors in living cells

  Ryou Kubota; Shigeki Kiyonaka; Itaru Hamachi

  Methods in Enzymology, 2019, Peer-reviewed

  
• Phototriggered Spatially Controlled Out-of-Equilibrium Patterns of Peptide Nanofibers in a Self-Sorting Double Network Hydrogel

  Keisuke Nakamura; Wataru Tanaka; Kei Sada; Ryou Kubota; Takuma Aoyama; Kenji Urayama; Itaru Hamachi

  Journal of the American Chemical Society, 24 Nov. 2021, Peer-reviewed

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• Light-induced stabilization of microtubules by photo-crosslinking of a Tau-derived peptide

  Soei Watari; Hiroshi Inaba; Tomonori Tamura; Arif Md. Rashedul Kabir; Akira Kakugo; Kazuki Sada; Itaru Hamachi; Kazunori Matsuura

  Chemical Communications, 2022

  
• Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue.

  Kento Ojima; Wataru Kakegawa; Tokiwa Yamasaki; Yuta Miura; Masayuki Itoh; Yukiko Michibata; Ryou Kubota; Tomohiro Doura; Eriko Miura; Hiroshi Nonaka; Seiya Mizuno; Satoru Takahashi; Michisuke Yuzaki; Itaru Hamachi; Shigeki Kiyonaka

  Nature communications, 16 Jun. 2022

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• Semi-wet Protein/peptide Array Utilizing Supramolecular Hydrogel

  TAMARU Shun-ichi; HAMACHI Itaru

  Seibutsu Butsuri, 25 Sep. 2006

  
• 内在性タンパク質に対する選択的ケミカルラベリングの新手法 : リガンド指向型トシル化学によるラベル化の可能性

  田村 朋則; 浜地 格

  化学と生物, 01 Mar. 2010

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• Function regulation of hemoproteins through their specific interaction with unnatural organic molecules or molecular assemblies

  HAMACHI Itaru

  Seibutsu Butsuri, Aug. 1996

  
• 2I1412 Analysis of iron and other metalloporphyrins recognition and transport mechanism among IsdH, IsdA, IsdC from Staphylococcus aureus(Heme proteins 2,The 48th Annual Meeting of the Biophysical Society of Japan)

  Moriwaki Yoshitaka; Terada Tohru; Caaveiro Jose Manuel Martinez; Tsutsumi Hiroshi; Hamachi Itaru; Tsumoto Kouhei; Shimizu Kentaro

  Seibutsu Butsuri, 2011

  
• Extracellular ATP Limits Homeostatic T Cell Migration Within Lymph Nodes.

  Daichi Kobayashi; Yuki Sugiura; Eiji Umemoto; Akira Takeda; Hisashi Ueta; Haruko Hayasaka; Shinsuke Matsuzaki; Tomoya Katakai; Makoto Suematsu; Itaru Hamachi; Gennady G Yegutkin; Marko Salmi; Sirpa Jalkanen; Masayuki Miyasaka

  Frontiers in immunology, 2021

  
• Orthogonal activation of metabotropic glutamate receptor using coordination chemogenetics

  Akinobu Senoo; Yutaro Yamada; Kento Ojima; Tomohiro Doura; Itaru Hamachi; Shigeki Kiyonaka

  26 Nov. 2021

  
• Ligand-directed two-step labeling to quantify neuronal glutamate receptor trafficking

  Kento Ojima; Kazuki Shiraiwa; Kyohei Soga; Tomohiro Doura; Mikiko Takato; Kazuhiro Komatsu; Michisuke Yuzaki; Itaru Hamachi; Shigeki Kiyonaka

  Nature Communications, Dec. 2021

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• 生細胞内のリン脂質動態を観察するためのオルガネラ選択的な化学ラベル化法

  土谷 正樹; 浜地 格

  臨床免疫・アレルギー科 = Clinical immunology & allergology, Jun. 2021, Peer-reviewed

  
• Microscopic Imaging Techniques for Molecular Assemblies: Electron, Atomic Force, and Confocal Microscopies

  Ryou Kubota; Wataru Tanaka; Itaru Hamachi

  Chemical Reviews, 04 May 2021

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• Enhanced Suppression of a Protein–Protein Interaction in Cells Using Small-Molecule Covalent Inhibitors Based on an N-Acyl-N-alkyl Sulfonamide Warhead

  Tsuyoshi Ueda; Tomonori Tamura; Masaharu Kawano; Keiya Shiono; Fruzsina Hobor; Andrew J. Wilson; Itaru Hamachi

  Journal of the American Chemical Society, 31 Mar. 2021

  
• Recent applications of N-acyl imidazole chemistry in chemical biology

  Takeharu Mino; Seiji Sakamoto; Itaru Hamachi

  BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, Jan. 2021, Peer-reviewed

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• Site-specific covalent labeling of His-tag fused proteins with N-acyl-N-alkyl sulfonamide reagent

  Vikram Thimaradka; Jae Hoon Oh; Christina Heroven; A. Radu Aricescu; Michisuke Yuzaki; Tomonori Tamura; Itaru Hamachi

  Bioorganic & Medicinal Chemistry, Jan. 2021

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• Organelle membrane-specific chemical labeling and dynamic imaging in living cells.

  Tomonori Tamura; Alma Fujisawa; Masaki Tsuchiya; Yuying Shen; Kohjiro Nagao; Shin Kawano; Yasushi Tamura; Toshiya Endo; Masato Umeda; Itaru Hamachi

  Nature chemical biology, Dec. 2020

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• Control of seed formation allows two distinct self-sorting patterns of supramolecular nanofibers

  Ryou Kubota; Kazutoshi Nagao; Wataru Tanaka; Ryotaro Matsumura; Takuma Aoyama; Kenji Urayama; Itaru Hamachi

  Nature Communications, Dec. 2020

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• Protein-responsive protein release of supramolecular/polymer hydrogel composite integrating enzyme activation systems

  Hajime Shigemitsu; Ryou Kubota; Keisuke Nakamura; Tomonobu Matsuzaki; Saori Minami; Takuma Aoyama; Kenji Urayama; Itaru Hamachi

  Nature Communications, Dec. 2020

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• Force generation by a propagating wave of supramolecular nanofibers

  Ryou Kubota; Masahiro Makuta; Ryo Suzuki; Masatoshi Ichikawa; Motomu Tanaka; Itaru Hamachi

  Nature Communications, Dec. 2020, Peer-reviewed

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• In Situ Real-time Confocal Imaging of a Self-assembling Peptide-grafted Polymer Showing pH-responsive Hydrogelation

  Ryou Kubota; Shogo Torigoe; Shuang Liu; Itaru Hamachi

  Chemistry Letters, 05 Nov. 2020

  
• Fluorescence imaging of drug target proteins using chemical probes

  Hao Zhu; Itaru Hamachi

  JOURNAL OF PHARMACEUTICAL ANALYSIS, Oct. 2020, Peer-reviewed

  
• Imaging and Profiling of Proteins under Oxidative Conditions in Cells and Tissues by Hydrogen-Peroxide-Responsive Labeling

  Hao Zhu; Tomonori Tamura; Alma Fujisawa; Yuki Nishikawa; Rong Cheng; Mikiko Takato; Itaru Hamachi

  Journal of the American Chemical Society, 16 Sep. 2020

  
• Activity-Based Sensing with a Metal-Directed Acyl Imidazole Strategy Reveals Cell Type-Dependent Pools of Labile Brain Copper

  Sumin Lee; Clive Yik-Sham Chung; Pei Liu; Laura Craciun; Yuki Nishikawa; Kevin J. Bruemmer; Itaru Hamachi; Kaoru Saijo; Evan W. Miller; Christopher J. Chang

  Journal of the American Chemical Society, 02 Sep. 2020, Peer-reviewed

  
• Chemical Tools for Endogenous Protein Labeling and Profiling

  Kazuki Shiraiwa; Rong Cheng; Hiroshi Nonaka; Tomonori Tamura; Itaru Hamachi

  CELL CHEMICAL BIOLOGY, Aug. 2020, Peer-reviewed

  
• Fluorescence determination of soluble pyrophosphate levels in synovial fluid as a marker of pseudogout using middle point of quantification concept and molecular sensor

  Nattha Yongwattana; Nutsara Mekjinda; Wannee Thepsing; Supasara Ounsuk; Pravit Wongkongkatep; Tulyapruek Tawonsawatruk; Itaru Hamachi; Akio Ojida; Jirarut Wongkongkatep

  SCIENCEASIA, Mar. 2020, Peer-reviewed

  
• Fluorescence Differentiation of ATP-Related Multiple Enzymatic Activities in Synovial Fluid as a Marker of Calcium Pyrophosphate Deposition Disease Using Kyoto Green

  Nattha Yongwattana; Nutsara Mekjinda; Tulyapruek Tawonsawatruk; Itaru Hamachi; Akio Ojida; Jirarut Wongkongkatep

  MOLECULES, Mar. 2020, Peer-reviewed

  
• Masking Phosphate with Rare-Earth Elements Enables Selective Detection of Arsenate by Dipycolylamine-Zn-II Chemosensor

  Nutsara Mekjinda; Supho Phunnarungsi; Vithaya Ruangpornvisuti; Raymond J. Ritchie; Itaru Hamachi; Akio Ojida; Jirarut Wongkongkatep

  SCIENTIFIC REPORTS, Feb. 2020, Peer-reviewed

  
• Development of a Photoactivatable Proximity Labeling Method for the Identification of Nuclear Proteins

  Tomonori Tamura; Mikiko Takato; Keiya Shiono; Itaru Hamachi

  CHEMISTRY LETTERS, Feb. 2020, Peer-reviewed

  
• Development of a Cell-Based Ligand-Screening System for Identifying Hsp90 Inhibitors

  Tsuyoshi Ueda; Tomonori Tamura; Itaru Hamachi

  Biochemistry, 21 Jan. 2020, Peer-reviewed

  
• The Power of Confocal Laser Scanning Microscopy in Supramolecular Chemistry: In situ Real‐time Imaging of Stimuli‐Responsive Multicomponent Supramolecular Hydrogels

  Ryou Kubota; Keisuke Nakamura; Shogo Torigoe; Itaru Hamachi

  ChemistryOpen, Jan. 2020, Peer-reviewed

  
• Electron Microscopic Detection of Single Membrane Proteins by a Specific Chemical Labeling

  Shigekazu Tabata; Marijo Jevtic; Nobutaka Kurashige; Hirokazu Fuchida; Munetsugu Kido; Kazushi Tani; Naoki Zenmyo; Shohei Uchinomiya; Harumi Harada; Makoto Itakura; Itaru Hamachi; Ryuichi Shigemoto; Akio Ojida

  ISCIENCE, Dec. 2019, Peer-reviewed

  
• pH Nanosensor Using Electronic Spins in Diamond

  Takahiro Fujisaku; Ryotaro Tanabe; Shinobu Onoda; Ryou Kubota; Takuya F. Segawa; Frederick T.-K. So; Takeshi Ohshima; Itaru Hamachi; Masahiro Shirakawa; Ryuji Igarashi

  ACS Nano, 22 Oct. 2019, Peer-reviewed

  
• Construction of ligand assay systems by protein-based semisynthetic biosensors

  Seiji Sakamoto; Shigeki Kiyonaka; Itaru Hamachi

  CURRENT OPINION IN CHEMICAL BIOLOGY, Jun. 2019, Peer-reviewed

  
• Optimized Reaction Pair of the CysHis Tag and Ni(II)-NTA Probe for Highly Selective Chemical Labeling of Membrane Proteins

  Naoki Zenmyo; Hiroki Tokumaru; Shohei Uchinomiya; Hirokazu Fuchida; Shigekazu Tabata; Itaru Hamachi; Ryuichi Shigemoto; Akio Ojida

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, May 2019, Peer-reviewed

  
• Development of a Nitric Oxide-Responsive Labeling Reagent for Proteome Analysis of Live Cells.

  Yuki Nishikawa; Takayuki Miki; Masashi Awa; Keiko Kuwata; Tomonori Tamura; Itaru Hamachi

  ACS chemical biology, 15 Mar. 2019, Peer-reviewed

  
• Selective and reversible modification of kinase cysteines with chlorofluoroacetamides.

  Naoya Shindo; Hirokazu Fuchida; Mami Sato; Kosuke Watari; Tomohiro Shibata; Keiko Kuwata; Chizuru Miura; Kei Okamoto; Yuji Hatsuyama; Keisuke Tokunaga; Seiichi Sakamoto; Satoshi Morimoto; Yoshito Abe; Mitsunori Shiroishi; Jose M M Caaveiro; Tadashi Ueda; Tomonori Tamura; Naoya Matsunaga; Takaharu Nakao; Satoru Koyanagi; Shigehiro Ohdo; Yasuchika Yamaguchi; Itaru Hamachi; Mayumi Ono; Akio Ojida

  Nature chemical biology, Mar. 2019, Peer-reviewed

  
• Chemistry for Covalent Modification of Endogenous/Native Proteins: From Test Tubes to Complex Biological Systems

  Tomonori Tamura; Itaru Hamachi

  Journal of the American Chemical Society, 20 Feb. 2019, Peer-reviewed

  
• Chemical proteomics for subcellular proteome analysis

  Hao Zhu; Tomonori Tamura; Itaru Hamachi

  CURRENT OPINION IN CHEMICAL BIOLOGY, Feb. 2019, Peer-reviewed

  
• Ligand-Directed N-Sulfonyl Pyridone Chemistry for Selective Native Protein Labeling and Imaging in Live Cell.

  Marie Masuda; Kazuya Matsuo; Itaru Hamachi

  Methods in molecular biology (Clifton, N.J.), 2019

  
• Recent Progress in Chemical Modification of Proteins

  Seiji Sakamoto; Itaru Hamachi

  ANALYTICAL SCIENCES, Jan. 2019, Peer-reviewed

  
• Chemical Profiling of the Endoplasmic Reticulum Proteome Using Designer Labeling Reagents.

  Alma Fujisawa; Tomonori Tamura; Yuki Yasueda; Keiko Kuwata; Itaru Hamachi

  Journal of the American Chemical Society, 12 Dec. 2018, Peer-reviewed

  
• Rapid labelling and covalent inhibition of intracellular native proteins using ligand-directed N-Acyl-N-Alkyl sulfonamide

  Tomonori Tamura; Tsuyoshi Ueda; Taiki Goto; Taku Tsukidate; Yonatan Shapira; Yuki Nishikawa; Alma Fujisawa; Itaru Hamachi

  Nature Communications, 01 Dec. 2018, Peer-reviewed

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• Shank and Zinc Mediate an AMPA Receptor Subunit Switch in Developing Neurons

  Huong T. T. Ha; Sergio Leal-Ortiz; Kriti Lalwani; Shigeki Kiyonaka; Itaru Hamachi; Shreesh P. Mysore; Johanna M. Montgomery; Craig C. Garner; John R. Huguenard; Sally A. Kim

  FRONTIERS IN MOLECULAR NEUROSCIENCE, Nov. 2018, Peer-reviewed

  
• Chemogenetic Approach Using Ni(II) Complex–Agonist Conjugates Allows Selective Activation of Class A G-Protein-Coupled Receptors

  Ryou Kubota; Wataru Nomura; Takuma Iwasaka; Kento Ojima; Shigeki Kiyonaka; Itaru Hamachi

  ACS Central Science, 26 Sep. 2018, Peer-reviewed

  
• Ligand-Directed Chemistry of AMPA Receptors Confers Live-Cell Fluorescent Biosensors

  Shigeki Kiyonaka; Seiji Sakamoto; Sho Wakayama; Yuma Morikawa; Muneo Tsujikawa; Itaru Hamachi

  ACS Chemical Biology, 20 Jul. 2018, Peer-reviewed

  
• Imaging-Based Study on Control Factors over Self-Sorting of Supramolecular Nanofibers Formed from Peptide- and Lipid-type Hydrogelators.

  Ryou Kubota; Shuang Liu; Hajime Shigemitsu; Keisuke Nakamura; Wataru Tanaka; Masato Ikeda; Itaru Hamachi

  Bioconjugate chemistry, 20 Jun. 2018, Peer-reviewed

  
• Endogenous Membrane Receptor Labeling by Reactive Cytokines and Growth Factors to Chase Their Dynamics in Live Cells

  Yousuke Takaoka; Shohei Uchinomiya; Daichi Kobayashi; Masataka Endo; Takahiro Hayashi; Yoshiaki Fukuyama; Haruko Hayasaka; Masayuki Miyasaka; Takumi Ueda; Ichio Shimada; Itaru Hamachi

  Chem, 14 Jun. 2018, Peer-reviewed

  
• コンディショナルプロテオミクスによる亜鉛周辺タンパク質のプロファイリング (特集 生体内金属の動態解明とその制御 : 分子から細胞,臨床まで)

  田村 朋則; 浜地 格

  生化学, Jun. 2018

  
• In Situ Construction of Protein-Based Semisynthetic Biosensors

  Tsuyoshi Ueda; Tomonori Tamura; Itaru Hamachi

  ACS Sensors, 23 Mar. 2018, Peer-reviewed

  
• An adaptive supramolecular hydrogel comprising self-sorting double nanofibre networks

  Hajime Shigemitsu; Takahiro Fujisaku; Wataru Tanaka; Ryou Kubota; Saori Minami; Kenji Urayama; Itaru Hamachi

  NATURE NANOTECHNOLOGY, Feb. 2018, Peer-reviewed

  
• Live-Cell Protein Sulfonylation Based on Proximity-driven N-Sulfonyl Pyridone Chemistry

  Kazuya Matsuo; Yuki Nishikawa; Marie Masuda; Itaru Hamachi

  Angewandte Chemie - International Edition, 15 Jan. 2018, Peer-reviewed

  
• An adaptive supramolecular hydrogel comprising self-sorting double nanofibre networks (vol 13, pg 165, 2018)

  Shigemitsu, Hajime; Fujisaku, Takahiro; Tanaka, Wataru; Kubota, Ryou; Minami, Saori; Urayama, Kenji; Hamachi, Itaru

  Nature Nanotechnology, 2018, Peer-reviewed

  
• Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins

  Sarah Hostachy; Marie Masuda; Takayuki Miki; Itaru Hamachi; Sandrine Sagan; Olivier Lequin; Kadda Medjoubi; Andrea Somogyi; Nicolas Delsuc; Clotilde Policar

  Chemical Science, 2018, Peer-reviewed

  
• 生体金属動態の分子科学-「生命金属科学」への展開 コンディショナルプロテオミクスによる亜鉛関連タンパク質群の同定

  田村 朋則; 三木 卓幸; 西川 雄貴; 清中 茂樹; 若林 真樹; 石濱 泰; 浜地 格

  生命科学系学会合同年次大会, Dec. 2017, Peer-reviewed

  
• Supramolecular hydrogels toward multi- 1 component systems

  Itaru Hamachi; Hajime Shigemitsu

  Kobunshi, Dec. 2017, Peer-reviewed

  
• Recognition-driven chemical labeling of endogenous proteins in multi-molecular crowding in live cells

  Kazuma Amaike; Tomonori Tamura; Itaru Hamachi

  CHEMICAL COMMUNICATIONS, Nov. 2017, Peer-reviewed

  
• Affinity-Guided Oxime Chemistry for Selective Protein Acylation in Live Tissue Systems

  Tomonori Tamura; Zhining Song; Kazuma Amaike; Shin Lee; Sifei Yin; Shigeki Kiyonaka; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Oct. 2017, Peer-reviewed

  
• In Situ Protein Labeling in Complex Environments

  T. Tamura; H. Shigemitsu; I. Hamachi

  Comprehensive Supramolecular Chemistry II, 22 Jun. 2017, Peer-reviewed

  
• A host-guest system based on collagen-like triple-helix hybridization

  N. Delsuc; S. Uchinomiya; A. Ojida; I. Hamachi

  CHEMICAL COMMUNICATIONS, Jun. 2017, Peer-reviewed

  
• THE LEVEL OF ATP ON THE PLASMA MEMBRANE OF NEUTROPHILS NEGATIVELY CORRELATES WITH SEVERITY OF SEPSIS

  Juri Saso; Yohei Hirano; Koichiro Sueyoshi; Yuka Sumi; Yoko Kuroda; Kumiko Ishii; Hitoshi Nakayama; Kazuhisa Iwabuchi; Yasutaka Kurishita; Hajime Shigemitsu; Itaru Hamachi; Hiroshi Tanaka

  SHOCK, Jun. 2017, Peer-reviewed

  
• Chemical labelling for visualizing native AMPA receptors in live neurons

  Sho Wakayama; Shigeki Kiyonaka; Itaru Arai; Wataru Kakegawa; Shinji Matsuda; Keiji Ibata; Yuri L. Nemoto; Akihiro Kusumi; Michisuke Yuzaki; Itaru Hamachi

  NATURE COMMUNICATIONS, Apr. 2017, Peer-reviewed

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• Design Strategies of Stimuli-Responsive Supramolecular Hydrogels Relying on Structural Analyses and Cell-Mimicking Approaches

  Hajime Shigemitsu; Itaru Hamachi

  ACCOUNTS OF CHEMICAL RESEARCH, Apr. 2017, Peer-reviewed

  
• Fluorescence Sensing of Inorganic Phosphate and Pyrophosphate Using Small Molecular Sensors and Their Applications

  Jirarut Wongkongkatep; Akio Ojida; Itaru Hamachi

  TOPICS IN CURRENT CHEMISTRY, Apr. 2017, Peer-reviewed

  
• Visualization of organelle-specific thermodynamics

  Yuta Yasuyoshi; Masahiko Hatano; Reiko Sakaguchi; Shigeki Kiyonaka; Itaru Hamachi; Takashi Morii; Takenao Yoshizaki; Yasuo Mori

  JOURNAL OF PHARMACOLOGICAL SCIENCES, Mar. 2017

  
• Ligand-Directed Tosyl and Acyl Imidazole Chemisrty

  Kazuya Matsuo; Itaru Hamachi

  Chemoselective and Bioorthogonal Ligation Reactions: Concepts and Applications, 2017, Peer-reviewed

  
• Chemical labelling for visualizing native AMPA receptors in live neurons

  Sho Wakayama; Shigeki Kiyonaka; Itaru Arai; Wataru Kakegawa; Shinji Matsuda; Keiji Ibata; Yuri L. Nemoto; Akihiro Kusumi; Michisuke Yuzaki; Itaru Hamachi

  NATURE COMMUNICATIONS, Apr. 2017, Peer-reviewed

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• Construction of Protein-Based Biosensors Using Ligand-Directed Chemistry for Detecting Analyte Binding

  Kei Yamaura; Shigeki Kiyonaka; Itaru Hamachi

  ENZYMES AS SENSORS, 2017, Peer-reviewed

  
• Allosteric activation of membrane-bound glutamate receptors using coordination chemistry within living cells

  Shigeki Kiyonaka; Ryou Kubota; Yukiko Michibata; Masayoshi Sakakura; Hideo Takahashi; Tomohiro Numata; Ryuji Inoue; Michisuke Yuzaki; Itaru Hamachi

  NATURE CHEMISTRY, Oct. 2016, Peer-reviewed

  
• Discovery of allosteric modulators for GABA(A) receptors by ligand-directed chemistry

  Kei Yamaura; Shigeki Kiyonaka; Tomohiro Numata; Ryuji Inoue; Itaru Hamachi

  NATURE CHEMICAL BIOLOGY, Oct. 2016, Peer-reviewed

  
• Preparation of supramolecular hydrogel-enzyme hybrids exhibiting biomolecule-responsive gel degradation

  Hajime Shigemitsu; Takahiro Fujisaku; Shoji Onogi; Tatsuyuki Yoshii; Masato Ikeda; Itaru Hamachi

  NATURE PROTOCOLS, Sep. 2016, Peer-reviewed

  
• In situ real-time imaging of self-sorted supramolecular nanofibres

  Shoji Onogi; Hajime Shigemitsu; Tatsuyuki Yoshii; Tatsuya Tanida; Masato Ikeda; Ryou Kubota; Itaru Hamachi

  NATURE CHEMISTRY, Aug. 2016, Peer-reviewed

  
• Fluorescence imaging of ATP in neutrophils from patients with sepsis using organelle-localizable fluorescent chemosensors

  Koichiro Sueyoshi; Yuka Sumi; Yoshiaki Inoue; Yoko Kuroda; Kumiko Ishii; Hitoshi Nakayama; Kazuhisa Iwabuchi; Yasutaka Kurishita; Hajime Shigemitsu; Itaru Hamachi; Hiroshi Tanaka

  ANNALS OF INTENSIVE CARE, Jul. 2016, Peer-reviewed

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• A Set of Organelle-Localizable Reactive Molecules for Mitochondrial Chemical Proteomics in Living Cells and Brain Tissues.

  Yuki Yasueda; Tomonori Tamura; Alma Fujisawa; Keiko Kuwata; Shinya Tsukiji; Shigeki Kiyonaka; Itaru Hamachi

  Journal of the American Chemical Society, 22 Jun. 2016, Peer-reviewed

  
• Recent Advance in Organic Chemistry for Protein Labeling under Live Cell Conditions

  Yuki Nishikawa; Tomonori Tamura; Itaru Hamachi

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, May 2016, Peer-reviewed

  
• Nucleus-selective Chemical Proteomics Using Hoechst-tagged Reactive Molecules

  Yuki Yasueda; Tomonori Tamura; Itaru Hamachi

  CHEMISTRY LETTERS, Mar. 2016, Peer-reviewed

  
• Allosteric activation of glutamate receptors by on-cell coordination chemistry

  Kiyonaka; Ryou Kubota; Yukiko Michibata; Masayoshi Sakakura; Hideo Takahashi; Tomohiro Numata; Ryuji Inoue; Michisuke Yuzaki; Itaru Hamachi

  Nature Chemistry, 2016, Peer-reviewed

  
• A conditional proteomics approach to identify proteins involved in zinc homeostasis

  Takayuki Miki; Masashi Awa; Yuki Nishikawa; Shigeki Kiyonaka; Masaki Wakabayashi; Yasushi Ishihama; Itaru Hamachi

  NATURE METHODS, Nov. 2016, Peer-reviewed

  
• Ligation of Glycophorin A Generates Reactive Oxygen Species Leading to Decreased Red Blood Cell Function

  Joseph Khoory; Jessica Estanislau; Abdallah Elkhal; Asmae Lazaar; Mark I. Melhorn; Abigail Brodsky; Ben Illigens; Itaru Hamachi; Yasutaka Kurishita; Alexander R. Ivanov; Sergey Shevkoplyas; Nathan I. Shapiro; Ionita C. Ghiran

  PLOS ONE, Jan. 2016, Peer-reviewed

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• Biomembrane-embedded Catalysts for Membrane-associated Protein Labeling on Red Blood Cells

  Yuki Yasueda; Tomonori Tamura; Keiko Kuwara; Yousuke Takaoka; Itaru Hamachi

  CHEMISTRY LETTERS, Dec. 2015, Peer-reviewed

  
• Supramolecular Assemblies Responsive to Biomolecules toward Biological Applications

  Hajime Shigemitsu; Itaru Hamachi

  CHEMISTRY-AN ASIAN JOURNAL, Oct. 2015, Peer-reviewed

  
• Validating subcellular thermal changes revealed by fluorescent thermosensors

  Shigeki Kiyonaka; Reiko Sakaguchi; Itaru Hamachi; Takashi Morii; Takenao Yoshizaki; Yasuo Mori

  NATURE METHODS, Sep. 2015, Peer-reviewed

  
• Design of Coordination Interaction of Zn(II) Complex with Oligo-Aspartate Peptide to Afford a High-Affinity Tag-Probe Pair

  Hirokazu Fuchida; Shigekazu Tabata; Naoya Shindo; Ippei Takashima; Qiao Leng; Yuji Hatsuyama; Itaru Hamachi; Akio Ojida

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Jun. 2015, Peer-reviewed

  
• Protein Recognition with Synthetic Small-molecular Binders toward Optical Protein Sensing in Vitro and in Live Cells

  R. Kubota; I. Hamachi

  Chem. Soc. Rev., Jun. 2015, Peer-reviewed

  
• Chemically Reactive Supramolecular Hydrogel Coupled with a Signal Amplification System for Enhanced Analyte Sensitivity

  Tatsuyuki Yoshii; Shoji Onogi; Hajime Shigemitsu; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2015, Peer-reviewed

  
• Extended Affinity-guided DMAP Chemistry with a Finely Tuned Acyl Donor for Intracellular FKBP12 Labeling

  Zhining Song; Yousuke Takaoka; Yoshiyuki Kioi; Kazuhiro Komatsu; Tomonori Tamura; Takayuki Miki; Itaru Hamachi

  CHEMISTRY LETTERS, Mar. 2015, Peer-reviewed

  
• Rapid and quantitative fluorescence detection of pathogenic spore-forming bacteria using a xanthene-Zn(II) complex chemosensor

  Perapon Tiposoth; Somruethai Khamsakhon; Napong Ketsub; Thunyarat Pongtharangkul; Ippei Takashima; Akio Ojida; Itaru Hamachi; Jirarut Wongkongkatep

  SENSORS AND ACTUATORS B-CHEMICAL, Mar. 2015, Peer-reviewed

  
• Ligand-directed tosyl chemistry for selective native protein labeling in vitro, in cells, and in vivo

  Shinya Tsukiji; Itaru Hamachi

  Site-Specific Protein Labeling: Methods and Protocols, 05 Jan. 2015, Peer-reviewed

  
• Labeling proteins by affinity-guided dmap chemistry

  Tomonori Tamura; Itaru Hamachi

  Site-Specific Protein Labeling: Methods and Protocols, 05 Jan. 2015, Peer-reviewed

  
• Protein recognition using synthetic small-molecular binders toward optical protein sensing in vitro and in live cells

  Ryou Kubota; Itaru Hamachi

  CHEMICAL SOCIETY REVIEWS, 2015, Peer-reviewed

  
• Development of an AND Logic-Gate-Type Fluorescent Probe for Ratiometric Imaging of Autolysosome in Cell Autophagy

  Ippei Takashima; Ryosuke Kawagoe; Itaru Hamachi; Akio Ojida

  CHEMISTRY-A EUROPEAN JOURNAL, Jan. 2015, Peer-reviewed

  
• Analysis of Cell-Surface Receptor Dynamics through Covalent Labeling by Catalyst-Tethered Antibody

  Takahiro Hayashi; Yuki Yasueda; Tomonori Tamura; Yousuke Takaoka; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2015, Peer-reviewed

  
• Ligand-directed dibromophenyl benzoate chemistry for rapid and selective acylation of intracellular natural proteins

  Yousuke Takaoka; Yuki Nishikawa; Yuki Hashimoto; Kenta Sasaki; Itaru Hamachi

  CHEMICAL SCIENCE, 2015, Peer-reviewed

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• Recent Progress in Design of Protein-Based Fluorescent Biosensors and Their Cellular Applications

  Tomonori Tamura; Itaru Hamachi

  ACS CHEMICAL BIOLOGY, Dec. 2014, Peer-reviewed

  
• Intracellular Protein-Responsive Supramolecules: Protein Sensing and In-Cell Construction of Inhibitor Assay System

  Tatsuyuki Yoshii; Keigo Mizusawa; Yousuke Takaoka; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 2014, Peer-reviewed

  
• LDAI-based chemical labeling of intact membrane proteins and its pulse-chase analysis under live cell conditions.

  Takayuki Miki; Sho-hei Fujishima; Kazuhiro Komatsu; Keiko Kuwata; Shigeki Kiyonaka; Itaru Hamachi

  Chemistry & biology, 14 Aug. 2014, Peer-reviewed

  
• Ligand-directed tosyl chemistry for in situ native protein labeling and engineering in living systems: from basic properties to applications

  Shinya Tsukiji; Itaru Hamachi

  CURRENT OPINION IN CHEMICAL BIOLOGY, Aug. 2014, Peer-reviewed

  
• Two-Photon-Responsive Supramolecular Hydrogel for Controlling Materials Motion in Micrometer Space

  Tatsuyuki Yoshii; Masato Ikeda; Itaru Hamachi

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, Jul. 2014, Peer-reviewed

  
• Design of a binuclear Ni(II)-iminodiacetic acid (IDA) complex for selective recognition and covalent labeling of His-tag fused proteins

  Ikuko Takahira; Hirokazu Fuchida; Shigekazu Tabata; Naoya Shindo; Shohei Uchinomiya; Itaru Hamachi; Akio Ojida

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jul. 2014, Peer-reviewed

  
• Installing logic-gate responses to a variety of biological substances in supramolecular hydrogel-enzyme hybrids

  Masato Ikeda; Tatsuya Tanida; Tatsuyuki Yoshii; Kazuya Kurotani; Shoji Onogi; Kenji Urayama; Itaru Hamachi

  NATURE CHEMISTRY, Jun. 2014, Peer-reviewed

  
• Peptide Tag/Probe Pairs Based on the Coordination Chemistry for Protein Labeling

  Shohei Uchinomiya; Akio Osjida; Itaru Hamachi

  INORGANIC CHEMISTRY, Feb. 2014, Peer-reviewed

  
• Design of Ratiometric Fluorescent Probes Based on Arene-Metal-Ion Interactions and Their Application to Cd-II and Hydrogen Sulfide Imaging in Living Cells

  Ippei Takashima; Miyuki Kinoshita; Ryosuke Kawagoe; Saika Nakagawa; Manabu Sugimoto; Itaru Hamachi; Akio Ojida

  CHEMISTRY-A EUROPEAN JOURNAL, Feb. 2014, Peer-reviewed

  
• Design of peptide-based bolaamphiphiles exhibiting heat-set hydrogelation via retro-Diels-Alder reaction

  Rika Ochi; Takashi Nishida; Masato Ikeda; Itaru Hamachi

  JOURNAL OF MATERIALS CHEMISTRY B, 2014, Peer-reviewed

  
• Live cell off-target identification of lapatinib using ligand-directed tosyl chemistry

  Kei Yamaura; Keiko Kuwata; Tomonori Tamura; Yoshiyuki Kioi; Yousuke Takaoka; Shigeki Kiyonaka; Itaru Hamachi

  CHEMICAL COMMUNICATIONS, 2014, Peer-reviewed

  
• Installing logic-gate responses to a variety of biological substances in supramolecular hydrogel-enzyme hybrids

  Masato Ikeda; Tatsuya Tanida; Tatsuyuki Yoshii; Kazuya Kurotani; Shoji Onogi; Kenji Urayama; Itaru Hamachi

  NATURE CHEMISTRY, Jun. 2014, Peer-reviewed

  
• Hoechst tagging: a modular strategy to design synthetic fluorescent probes for live-cell nucleus imaging

  Akinobu Nakamura; Kazumasa Takigawa; Yasutaka Kurishita; Keiko Kuwata; Manabu Ishida; Yasushi Shimoda; Itaru Hamachi; Shinya Tsukiji

  CHEMICAL COMMUNICATIONS, 2014, Peer-reviewed

  
• Heme binding mechanism of structurally similar iron-regulated surface determinant near transporter domains of staphylococcus aureus exhibiting different affinities for heme

  Yoshitaka Moriwaki; Tohru Terada; Jose M. M. Caaveiro; Yousuke Takaoka; Itaru Hamachi; Kouhei Tsumoto; Kentaro Shimizu

  Biochemistry, 10 Dec. 2013, Peer-reviewed

  
• Genetically encoded fluorescent thermosensors visualize subcellular thermoregulation in living cells

  Shigeki Kiyonaka; Taketoshi Kajimoto; Reiko Sakaguchi; Daisuke Shinmi; Mariko Omatsu-Kanbe; Hiroshi Matsuura; Hiromi Imamura; Takenao Yoshizaki; Itaru Hamachi; Takashi Morii; Yasuo Mori

  NATURE METHODS, Dec. 2013, Peer-reviewed

  
• Disassembly-driven Turn-on Sensing of Enzyme Activity by Substrate-based Fluorescent Nanoprobe

  Yousuke Takaoka; Yoshiaki Fukuyama; Kazuya Matsuo; Itaru Hamachi

  CHEMISTRY LETTERS, Nov. 2013, Peer-reviewed

  
• CR1-mediated ATP Release by Human Red Blood Cells Promotes CR1 Clustering and Modulates the Immune Transfer Process

  Mark I. Melhorn; Abigail S. Brodsky; Jessica Estanislau; Joseph A. Khoory; Ben Illigens; Itaru Hamachi; Yasutaka Kurishita; Andrew D. Fraser; Anne Nicholson-Weller; Elena Dolmatova; Heather S. Duffy; Ionita C. Ghiran

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2013, Peer-reviewed

  
• Specific Detection and Imaging of Enzyme Activity by Signal-Amplifiable Self-Assembling F-19 MRI Probes

  Kazuya Matsuo; Rui Kamada; Keigo Mizusawa; Hirohiko Imai; Yuki Takayama; Michiko Narazaki; Tetsuya Matsuda; Yousuke Takaoka; Itaru Hamachi

  CHEMISTRY-A EUROPEAN JOURNAL, Sep. 2013, Peer-reviewed

  
• Synthetic Self-Localizing Ligands That Control the Spatial Location of Proteins in Living Cells

  Manabu Ishida; Hideaki Watanabe; Kazumasa Takigawa; Yasutaka Kurishita; Choji Oki; Akinobu Nakamura; Itaru Hamachi; Shinya Tsukiji

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2013, Peer-reviewed

  
• Semisynthetic Lectin-4-Dimethylaminopyridine Conjugates for Labeling and Profiling Glycoproteins on Live Cell Surfaces

  Takahiro Hayashi; Yedi Sun; Tomonori Tamura; Keiko Kuwata; Zhining Song; Yousuke Takaoka; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2013, Peer-reviewed

  
• Ligand Directed Chemistry for Protein Labeling and Functionalization in Living Cells

  YASUEDA Yuki; HAMACHI Itaru

  Seibutsu Butsuri, 25 Jul. 2013

  
• Selective binding of antimicrobial porphyrins to the heme-receptor IsdH-NEAT3 of Staphylococcus aureus

  Nhuan T. Vu; Yoshitaka Moriwaki; Jose M. M. Caaveiro; Tohru Terada; Hiroshi Tsutsumi; Itaru Hamachi; Kentaro Shimizu; Kouhei Tsumoto

  Protein Science, Jul. 2013, Peer-reviewed

  
• Fluorophore labeling of native FKBP12 by ligand-directed tosyl chemistry allows detection of its molecular interactions in vitro and in living cells

  Tomonori Tamura; Yoshiyuki Kioi; Takayuki Miki; Shinya Tsukiji; Itaru Hamachi

  Journal of the American Chemical Society, 08 May 2013, Peer-reviewed

  
• Selective Labeling and Imaging of Protein Using Metal Complex

  Yasutaka Kurishita; Itaru Hamachi

  Coordination Chemistry in Protein Cages: Principles, Design, and Applications, 02 Apr. 2013, Peer-reviewed

  
• In-cell covalent labeling of reactive His-tag fused proteins

  Shohei Uchinomiya; Hiroshi Nonaka; Sho Wakayama; Akio Ojida; Itaru Hamachi

  CHEMICAL COMMUNICATIONS, 2013, Peer-reviewed

  
• One-step construction of caged carbonic anhydrase I using a ligand-directed acyl imidazole-based protein labeling method

  Kazuya Matsuo; Yoshiyuki Kioi; Ryosuke Yasui; Yousuke Takaoka; Takayuki Miki; Sho-hei Fujishima; Itaru Hamachi

  CHEMICAL SCIENCE, 2013, Peer-reviewed

  
• Protein Organic Chemistry and Applications for Labeling and Engineering in Live-Cell Systems

  Yousuke Takaoka; Akio Ojida; Itaru Hamachi

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, Peer-reviewed

  
• Quantitative comparison of protein dynamics in live cells and in vitro by in-cell F-19-NMR

  Yousuke Takaoka; Yoshiyuki Kioi; Akira Morito; Junji Otani; Kyohei Arita; Eishi Ashihara; Mariko Ariyoshi; Hidehito Tochio; Masahiro Shirakawa; Itaru Hamachi

  CHEMICAL COMMUNICATIONS, 2013, Peer-reviewed

  
• 3P041 Insights into the mechanism of heme-transfer between Isd NEAT domains of Staphylococcus aureus(01A. Protein: Structure,Poster)

  Moriwaki Yoshitaka; Terada Tohru; Caaveiro Jose M. M.; Takaoka Yousuke; Hamachi Itaru; Tsumoto Kouhei; Shimizu Kentaro

  Seibutsu Butsuri, 2013

  
• 2SBP-04 Chemical protein labeling in living systems for its analysis(2SBP Transient macromolecular complexes involved in multilevel biological phenomena,Symposium,The 51th Annual Meeting of the Biophysical Society of Japan)

  Hamachi Itaru

  Seibutsu Butsuri, 2013

  
• Supramolecular hydrogels based on bola-amphiphilic glycolipids showing color change in response to glycosidases

  Rika Ochi; Kazuya Kurotani; Masato Ikeda; Shigeki Kiyonaka; Itaru Hamachi

  CHEMICAL COMMUNICATIONS, 2013, Peer-reviewed

  
• Label-free Fluorescent Detection of Loop-mediated Isothermal Amplification of Nucleic Acid Using Pyrophosphate-selective Xanthene-based Zn(II)-coordination Chemosensor

  Ekkachai Kittiloespaisan; Akio Ojida; Itaru Hamachi; Yortyot Seetang-Nun; Wansika Kiatpathomchai; Jirarut Wongkongkatep

  CHEMISTRY LETTERS, Dec. 2012, Peer-reviewed

  
• What do we want to see and how? Editorial overview

  Itaru Hamachi

  CURRENT OPINION IN CHEMICAL BIOLOGY, Dec. 2012, Peer-reviewed

  
• Organelle-Localizable Fluorescent Chemosensors for Site-Specific Multicolor Imaging of Nucleoside Polyphosphate Dynamics in Living Cells

  Yasutaka Kurishita; Takahiro Kohira; Akio Ojida; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 2012, Peer-reviewed

  
• Heat-Induced Morphological Transformation of Supramolecular Nanostructures by Retro-Diels-Alder Reaction

  Masato Ikeda; Rika Ochi; Yu-shi Kurita; Darrin J. Pochan; Itaru Hamachi

  CHEMISTRY-A EUROPEAN JOURNAL, Oct. 2012, Peer-reviewed

  
• Traceless Affinity Labeling of Endogenous Proteins for Functional Analysis in Living Cells

  Takahiro Hayashi; Itaru Hamachi

  ACCOUNTS OF CHEMICAL RESEARCH, Sep. 2012, Peer-reviewed

  
• Specific Cell Surface Protein Imaging by Extended Self-Assembling Fluorescent Turn-on Nanoprobes

  Keigo Mizusawa; Yousuke Takaoka; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2012, Peer-reviewed

  
• Bacteria Interface Pickering Emulsions Stabilized by Self-assembled Bacteria-Chitosan Network

  Pravit Wongkongkatep; Khajohnpong Manopwisedjaroen; Perapon Tiposoth; Somwit Archakunakorn; Thunyarat Pongtharangkul; Manop Suphantharika; Kohsuke Honda; Itaru Hamachi; Jirarut Wongkongkatep

  LANGMUIR, Apr. 2012, Peer-reviewed

  
• Ligand-Directed Acyl Imidazole Chemistry for Labeling of Membrane-Bound Proteins on Live Cells

  Sho-hei Fujishima; Ryosuke Yasui; Takayuki Miki; Akio Ojida; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2012, Peer-reviewed

  
• Native FKBP12 Engineering by Ligand-Directed Tosyl Chemistry: Labeling Properties and Application to Photo-Cross-Linking of Protein Complexes in Vitro and in Living Cells

  Tomonori Tamura; Shinya Tsukiji; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2012, Peer-reviewed

  
• Design of a multinuclear Zn(II) complex as a new molecular probe for fluorescence imaging of His-tag fused proteins

  Sho-hei Fujishima; Hiroshi Nonaka; Sho-hei Uchinomiya; Yoshiyuki Alex Kawase; Akio Ojida; Itaru Hamachi

  CHEMICAL COMMUNICATIONS, Jan. 2012, Peer-reviewed

  
• A supramolecular hydrogel containing boronic acid-appended receptor for fluorocolorimetric sensing of polyols with a paper platform

  Masato Ikeda; Keisuke Fukuda; Tatsuya Tanida; Tatsuyuki Yoshii; Itaru Hamachi

  CHEMICAL COMMUNICATIONS, 2012, Peer-reviewed

  
• Meter-Long and Robust Supramolecular Strands Encapsulated in Hydrogel Jackets

  Daisuke Kiriya; Masato Ikeda; Hiroaki Onoe; Masahiro Takinoue; Harunobu Komatsu; Yuto Shimoyama; Itaru Hamachi; Shoji Takeuchi

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, Peer-reviewed

  
• Phosphopeptide-Dependent Labeling of 14-3-3?? Proteins by Fusicoccin-Based Fluorescent Probes

  Michiko Takahashi; Akie Kawamura; Nobuo Kato; Tsuyoshi Nishi; Itaru Hamachi; Junko Ohkanda

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, Peer-reviewed

  
• Stiff, Multistimuli-Responsive Supramolecular Hydrogels as Unique Molds for 2D/3D Microarchitectures of Live Cells

  Harunobu Komatsu; Shinya Tsukiji; Masato Ikeda; Itaru Hamachi

  CHEMISTRY-AN ASIAN JOURNAL, Sep. 2011, Peer-reviewed

  
• Molecular Basis of Recognition of Antibacterial Porphyrins by Heme-Transporter IsdH-NEAT3 of Staphylococcus aureus

  Yoshitaka Moriwaki; Jose M. M. Caaveiro; Yoshikazu Tanaka; Hiroshi Tsutsumi; Itaru Hamachi; Kouhei Tsumoto

  BIOCHEMISTRY, Aug. 2011, Peer-reviewed

  
• Chemical Cell-Surface Receptor Engineering Using Affinity-Guided, Multivalent Organocatalysts

  Hangxiang Wang; Yoichiro Koshi; Daishiro Minato; Hiroshi Nonaka; Shigeld Kiyonaka; Yasuo Mori; Shinya Tsukiji; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2011, Peer-reviewed

  
• Systematic Study of Protein Detection Mechanism of Self-Assembling F-19 NMR/MRI Nanoprobes toward Rational Design and Improved Sensitivity

  Yousuke Takaoka; Keishi Kiminami; Keigo Mizusawa; Kazuya Matsuo; Michiko Narazaki; Tetsuya Matsuda; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2011, Peer-reviewed

  
• Construction of a F-19-lectin biosensor for glycoprotein imaging by using affinity-guided DMAP chemistry

  Yedi Sun; Yousuke Takaoka; Shinya Tsukiji; Michiko Narazaki; Tetsuya Matsuda; Itaru Hamachi

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Aug. 2011, Peer-reviewed

  
• Rational Molecular Design of Stimulus-Responsive Supramolecular Hydrogels Based on Dipeptides

  Masato Ikeda; Tatsuya Tanida; Tatsuyuki Yoshii; Itaru Hamachi

  ADVANCED MATERIALS, Jul. 2011, Peer-reviewed

  
• Rigid Luminescent Bis-Zinc(II)-Bis-Cyclen Complexes for the Detection of Phosphate Anions and Non-Covalent Protein Labeling in Aqueous Solution

  Mouchumi Bhuyan; Evgeny Katayev; Stefan Stadlbauer; Hiroshi Nonaka; Akio Ojida; Itaru Hamachi; Burkhard Koenig

  EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, May 2011, Peer-reviewed

  
• Montmorillonite-Supramolecular Hydrogel Hybrid for Fluorocolorimetric Sensing of Polyamines

  Masato Ikeda; Tatsuyuki Yoshii; Toshihiro Matsui; Tatsuya Tanida; Harunobu Komatsu; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2011, Peer-reviewed

  
• Mechanical Reinforcement of Supramolecular Hydrogel through Incorporation of Multiple Noncovalent Interactions

  Harunobu Komatsu; Masato Ikeda; Itaru Hamachi

  CHEMISTRY LETTERS, Feb. 2011, Peer-reviewed

  
• Mechanisms of chemical protein F-19-labeling and NMR-based biosensor construction in vitro and in cells using self-assembling ligand-directed tosylate compounds

  Yousuke Takaoka; Yedi Sun; Shinya Tsukiji; Itaru Hamachi

  CHEMICAL SCIENCE, 2011, Peer-reviewed

  
• Development of new methods of protein-selective labeling in living cells

  Kazuya Matsuo; Itaru Hamachi

  Seikagaku, 2011, Peer-reviewed

  
• Selective chemical labeling and engineering of endogenous cellular proteins

  Shinya Tsukiji; Manabu Ishida; Itaru Hamachi

  Seikagaku, 2011, Peer-reviewed

  
• Template synthesis in hydrodynamically-aligned supramolecular nano-channels

  Daisuke Kiriya; Hiroaki Onoe; Masato Ikeda; Itaru Hamachi; Shoji Takeuchi

  14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010, 01 Dec. 2010

  
• Supramolecular hydrogel capsule showing prostate specific antigen-responsive function for sensing and targeting prostate cancer cells

  Masato Ikeda; Rika Ochi; Atsuhiko Wada; Itaru Hamachi

  CHEMICAL SCIENCE, Oct. 2010, Peer-reviewed

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• Rational Design of FRET-Based Ratiometric Chemosensors for in Vitro and in Cell Fluorescence Analyses of Nucleoside Polyphosphates

  Yasutaka Kurishita; Takahiro Kohira; Akio Ojida; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2010, Peer-reviewed

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• Selective Covalent Labeling of Tag-Fused GPCR Proteins on Live Cell Surface with a Synthetic Probe for Their Functional Analysis

  Hiroshi Nonaka; Sho-hei Fujishima; Sho-hei Uchinomiya; Akio Ojida; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2010, Peer-reviewed

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• MEMS meets supramolecules: Aligning supramolecular fibers within hydrogel strand using a microfluidic channel

  Daisuke Kiriya; Hiroaki Onoe; Masato Ikeda; Itaru Hamachi; Shoji Takeuchi

  Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), 01 Jun. 2010

  
• Disassembly-Driven Turn-On Fluorescent Nanoprobes for Selective Protein Detection

  Keigo Mizusawa; Yoshiyuki Ishida; Yousuke Takaoka; Masayoshi Miyagawa; Shinya Tsukiji; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 2010, Peer-reviewed

  
• Development of Highly Sensitive Fluorescent Probes for Detection of Intracellular Copper(I) in Living Systems

  Masayasu Taki; Shohei Iyoshi; Akio Ojida; Itaru Hamachi; Yukio Yamamoto

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, May 2010, Peer-reviewed

  
• Fluidic supramolecular nano- and microfibres as molecular rails for regulated movement of nanosubstances

  Shun-ichi Tamaru; Masato Ikeda; Yusuke Shimidzu; Shinji Matsumoto; Shoji Takeuchi; Itaru Hamachi

  NATURE COMMUNICATIONS, May 2010, Peer-reviewed

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• Thermoresponsive Fluorescent Sensor Based on Core/Shell Nanocomposite Composed of Gold Nanoparticles and Poly(N-isopropylacrylamide)

  Jirarut Wongkongkatep; Runchuan Ladadat; Woraphoj Lappermpunsap; Pravit Wongkongkatep; Pranee Phinyocheep; Akio Ojida; Itaru Hamachi

  CHEMISTRY LETTERS, Mar. 2010, Peer-reviewed

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• Supramolecular hydrogel-based protein and chemosensor array

  Masato Ikeda; Rika Ochi; Itaru Hamachi

  LAB ON A CHIP, 2010, Peer-reviewed

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• Binuclear Ni-II-DpaTyr Complex as a High Affinity Probe for an Oligo-Aspartate Tag Tethered to Proteins

  Akio Ojida; Sho-hei Fujishima; Kei Honda; Hiroshi Nonaka; Sho-hei Uchinomiya; Itaru Hamachi

  CHEMISTRY-AN ASIAN JOURNAL, 2010, Peer-reviewed

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• FLAG-tag selective covalent protein labeling via a binding-induced acyl-transfer reaction

  Hiroshi Nonaka; Sho-hei Fujishima; Sho-hei Uchinomiya; Akio Ojida; Itaru Hamachi

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Dec. 2009, Peer-reviewed

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• Molecular Characterization of Flubendiamide Sensitivity in the Lepidopterous Ryanodine Receptor Ca2+ Release Channel

  Kenta Kato; Shigeki Kiyonaka; Yuichi Sawaguchi; Masanori Tohnishi; Takao Masaki; Noriaki Yasokawa; Yusuke Mizuno; Emiko Mori; Keisuke Inoue; Itaru Hamachi; Hiroshi Takeshima; Yasuo Mori

  BIOCHEMISTRY, Nov. 2009, Peer-reviewed

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• Recent Progress in Strategies for the Creation of Protein-Based Fluorescent Biosensors

  Hangxiang Wang; Eiji Nakata; Itaru Hamachi

  CHEMBIOCHEM, Nov. 2009, Peer-reviewed

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• Self-assembling nanoprobes that display off/on 19 F nuclear magnetic resonance signals for protein detection and imaging

  Yousuke Takaoka; Takashi Sakamoto; Shinya Tsukiji; Michiko Narazaki; Tetsuya Matsuda; Hidehito Tochio; Masahiro Shirakawa; Itaru Hamachi

  Nature Chemistry, Oct. 2009, Peer-reviewed

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• Thin-film assembly of diethanolamine-based lipidic material as potential gene carrier in mouse embryonic neural stem cells

  Ken-ichi Kusumoto; Satoko Yamashita; Takahiro Nagata; Takeshi Ido; Itaru Hamachi; Tetsuyuki Akao

  JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, Oct. 2009, Peer-reviewed

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• Quenched Ligand-Directed Tosylate Reagents for One-Step Construction of Turn-On Fluorescent Biosensors

  Shinya Tsukiji; Hangxiang Wang; Masayoshi Miyagawa; Tomonori Tamura; Yousuke Takaoka; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2009, Peer-reviewed

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• Ligand-directed tosyl chemistry for protein labeling in vivo

  Shinya Tsukiji; Masayoshi Miyagawa; Yousuke Takaoka; Tomonori Tamura; Itaru Hamachi

  NATURE CHEMICAL BIOLOGY, May 2009, Peer-reviewed

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• Supramolecular Hydrogel Exhibiting Four Basic Logic Gate Functions To Fine-Tune Substance Release

  Harunobu Komatsu; Shinji Matsumoto; Shun-ichi Tamaru; Kenji Kaneko; Masato Ikeda; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2009, Peer-reviewed

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• MCM-Enzyme-Supramolecular Hydrogel Hybrid as a Fluorescence Sensing Material for Polyanions of Biological Significance

  Atsuhiko Wada; Shun-ichi Tamaru; Masato Ikeda; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2009, Peer-reviewed

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• Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

  Shigeki Kiyonaka; Kenta Kato; Motohiro Nishida; Kazuhiro Mio; Takuro Numaga; Yuichi Sawaguchi; Takashi Yoshida; Minoru Wakamori; Emiko Mori; Tomohiro Numata; Masakazu Ishii; Hiroki Takemoto; Akio Ojida; Kenta Watanabe; Aya Uemura; Hitoshi Kurose; Takashi Morii; Tsutomu Kobayashi; Yoji Sato; Chikara Sato; Itaru Hamachi; Yasuo Mori

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2009, Peer-reviewed

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• Real-time fluorescence monitoring of GSK3$β$-catalyzed phosphoryation by use of a BODIPY-based Zn (II)--Dpa chemosensor

  Sakamoto, Takashi; Inoue, Masa-aki; Ojida, Akio; Hamachi, Itaru

  Bioorganic & medicinal chemistry letters, 2009, Peer-reviewed

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• Fluorescent BODIPY-based Zn (II) complex as a molecular probe for selective detection of neurofibrillary tangles in the brains of Alzheimer’s disease patients

  Ojida, Akio; Sakamoto, Takashi; Inoue, Masa-aki; Fujishima, Sho-hei; Lippens, Guy; Hamachi, Itaru

  Journal of the American Chemical Society, 2009, Peer-reviewed

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• Molecular recognition, fluorescence sensing, and biological assay of phosphate anion derivatives using artificial Zn (II)--Dpa complexes

  Sakamoto, Takashi; Ojida, Akio; Hamachi, Itaru

  Chemical Communications, 2009, Peer-reviewed

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• Site-specific covalent labeling of His-tag fused proteins with a reactive Ni(II)-NTA probe

  Sho-hei Uchinomiya; Hiroshi Nonaka; Sho-hei Fujishima; Shinya Tsukiji; Akio Ojida; Itaru Hamachi

  CHEMICAL COMMUNICATIONS, 2009, Peer-reviewed

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• Sequence selective dual-emission detection of (i, i+1) bis-phosphorylated peptide using diazastilbene-type Zn(II)-Dpa chemosensor

  Yoshiyuki Ishida; Masa-aki Inoue; Tomonori Inoue; Akio Ojida; Itaru Hamachi

  CHEMICAL COMMUNICATIONS, 2009, Peer-reviewed

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• Self-assembling nanoprobes that display off/on 19F nuclear magnetic resonance signals for protein detection and imaging

  Takaoka, Yousuke; Sakamoto, Takashi; Tsukiji, Shinya; Narazaki, Michiko; Matsuda, Tetsuya; Tochio, Hidehito; Shirakawa, Masahiro; Hamachi, Itaru

  Nature chemistry, 2009, Peer-reviewed

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• Selective and direct inhibition of TRPC3 channels underlies biological activities of the novel pyrazole compound

  Kenta Kato; Shigeki Kiyonaka; Motohiro Nishida; Kazuhiro Mio; Tomohiro Numata; Yuichi Sawaguchi; Emiko Mori; Chikara Sato; Itaru Hamachi; Yasuo Mori

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, Peer-reviewed

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• Mechanical Reinforcement of a Supramolecular Hydrogel Comprising an Artificial Glyco-Lipid through Supramolecular Copolymerization

  Masato Ikeda; Yusuke Shimizu; Shinji Matsumoto; Harunobu Komatsu; Shun-ichi Tamaru; Toshikazu Takigawa; Itaru Hamachi

  MACROMOLECULAR BIOSCIENCE, Nov. 2008, Peer-reviewed

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• Real-time Off/On-mode Fluorescence Assay for Enzyme Reactions Involving Nucleoside Polyphosphates by Use of a Xanthene Zn-II-Dpa Chemosensor

  Takahiro Kohira; Ippei Takashima; Hiroshi Nonaka; Akio Ojida; Itaru Hamachi

  CHEMISTRY LETTERS, Nov. 2008, Peer-reviewed

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• Fluorescence imaging of intracellular cadmium using a dual-excitation ratiometric chemosensor

  Masayasu Taki; Mika Desaki; Akio Ojida; Shohei Iyoshi; Tasuku Hirayama; Itaru Hamachi; Yukio Yamamoto

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2008, Peer-reviewed

  
• Turn-on fluorescence sensing of nucleoside polyphosphates using a xanthene-based Zn(II) complex chemosensor

  Akio Ojida; Ippei Takashima; Takahiro Kohira; Hiroshi Nonaka; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2008, Peer-reviewed

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• Artificial receptors designed for intracellular delivery of anionic phosphate derivatives

  Takahiro Kohira; Kei Honda; Akio Ojida; Itaru Hamachi

  CHEMBIOCHEM, Mar. 2008, Peer-reviewed

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• Target-specific chemical acylation of lectins by ligand-tethered DMAP catalysts

  Yoichiro Koshi; Eiji Nakata; Masayoshi Miyagawa; Shinya Tsukiji; Tomohisa Ogawa; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jan. 2008, Peer-reviewed

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• Ratiometric fluorescent biosensor for real-time and label-free monitoring of fine saccharide metabolic pathways

  Eiji Nakata; Hangxiang Wang; Itaru Hamachi

  CHEMBIOCHEM, Jan. 2008, Peer-reviewed

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• Three-Dimensional Encapsulation of Live Cells by Using a Hybrid Matrix of Nanoparticles in a Supramolecular Hydrogel

  Masato Ikeda; Shiori Ueno; Shinji Matsumoto; Yusuke Shimizu; Harunobu Komatsu; Ken-ichi Kusumoto; Itaru Hamachi

  CHEMISTRY-A EUROPEAN JOURNAL, 2008, Peer-reviewed

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• Recent progress of phosphate derivatives recognition utilizing artificial small molecular receptors in aqueous media

  Shun-ichi Tamaru; Itaru Hamachi

  RECOGNITION OF ANIONS, 2008, Peer-reviewed

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• Affinity-labeling-based introduction of a reactive handle for natural protein modification

  Haruto Wakabayashi; Masayoshi Miyagawa; Yoichiro Koshi; Yousuke Takaoka; Shinya Tsukiji; Itaru Hamachi

  CHEMISTRY-AN ASIAN JOURNAL, 2008, Peer-reviewed

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• Photo gel-sol/sol-gel transition and its patterning of a supramolecular hydrogel as stimuli-responsive biomaterials

  Shinji Matsumoto; Satoshi Yamaguchi; Shiori Ueno; Harunobu Komatsu; Masato Ikeda; Koji Ishizuka; Yuko Iko; Kazuhito V. Tabata; Hiroyuki Aoki; Shinzaburo Ito; Hiroyuki Noji; Itaru Hamachi

  CHEMISTRY-A EUROPEAN JOURNAL, 2008, Peer-reviewed

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• Photo-responsive gel droplet as a nano- or pico-litre container comprising a supramolecular hydrogel

  Shinji Matsumoto; Satoshi Yamaguchi; Atsuhiko Wada; Toshihiro Matsui; Masato Ikeda; Itaru Hamachi

  CHEMICAL COMMUNICATIONS, 2008, Peer-reviewed

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• Thermally responsive supramolecular nanomeshes for on/off switching of the rotary motion of F-1-ATPase at the single-molecule level

  Satoshi Yamaguchi; Shinji Matsumoto; Koji Ishizuka; Yuko Iko; Kazuhito V. Tabata; Hideyuki F. Arata; Hiroyuki Fujita; Hiroyuki Noji; Itaru Hamachi

  CHEMISTRY-A EUROPEAN JOURNAL, 2008, Peer-reviewed

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• Non-enzymatic covalent protein labeling using a reactive tag

  Hiroshi Nonaka; Shinya Tsukiji; Akio Ojida; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2007, Peer-reviewed

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• Pyrene excimer-based dual-emission detection of a oligoaspartate tag-fused protein by using a Zn-11-DpaTyr probe

  Kei Honda; Sho-hei Fujishima; Akio Ojida; Itaru Hamachi

  CHEMBIOCHEM, Aug. 2007, Peer-reviewed

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• Development of new methods to introduce unnatural functional molecules into native proteins for protein engineering

  E. Nakata; S. Tsukiji; I. Hamachi

  Bulletin of the Chemical Society of Japan, 15 Jul. 2007, Peer-reviewed

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• Development of new methods to introduce unnatural functional molecules into native proteins for protein engineering

  Eiji Nakata; Shinya Tsukiji; Itaru Hamachi

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Jul. 2007, Peer-reviewed

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• Design of a hybrid biosensor for enhanced phosphopeptide recognition based on a phosphoprotein binding domain coupled with a fluorescent chemosensor

  Takahiro Anai; Eiji Nakata; Yoichiro Koshi; Akio Ojida; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, May 2007, Peer-reviewed

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• Lectin functionalizaion by post-photo affinity Labeling modification (P-PALM)

  Koshi Yoichiro; Nakata Eiji; Hamachi Itaru

  TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY, May 2007, Peer-reviewed

  
• Design of a hybrid biosensor for enhanced phosphopeptide recognition based on a phosphoprotein binding domain coupled with a fluorescent chemosensor

  Takahiro Anai; Eiji Nakata; Yoichiro Koshi; Akio Ojida; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, May 2007, Peer-reviewed

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• Design of dual-emission chemosensors for ratiometric detection of ATP derivatives

  Akio Ojida; Yoshifumi Miyahara; Ararut Wongkongkatep; Shun-ichi Tamaru; Kazuki Sada; Itaru Hamachi

  CHEMISTRY-AN ASIAN JOURNAL, Oct. 2006, Peer-reviewed

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• Oligo-Asp Tag/Zn(II) complex probe as a new pair for labeling and fluorescence imaging of proteins

  Akio Ojida; Kei Honda; Daisuke Shinmi; Shigeki Kiyonaka; Yasuo Mori; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2006, Peer-reviewed

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• A fluorescent lectin array using supramolecular hydrogel for simple detection and pattern profiling for various glycoconjugates

  Yoichiro Koshi; Eiji Nakata; Hiroki Yamane; Itaru Hamachi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2006, Peer-reviewed

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• Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure

  Hirokazu Tamamura; Akio Ojida; Teppei Ogawa; Hiroshi Tsutsumi; Hiroyuki Masuno; Hideki Nakashima; Naoki Yamamoto; Itaru Hamachi; Nobutaka Fujii

  JOURNAL OF MEDICINAL CHEMISTRY, Jun. 2006, Peer-reviewed

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• One-pot and sequential organic chemistry on an enzyme surface to tether a fluorescent probe at the proximity of the active site with restoring enzyme activity

  Y Takaoka; H Tsutsumi; N Kasagi; E Nakata; Hamachi, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2006, Peer-reviewed

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• Effective disruption of phosphoprotein-protein surface interaction using Zn(II) dipicolylamine-based artificial receptors via two-point interaction

  A Ojida; M Inoue; Y Mito-oka; H Tsutsumi; K Sada; Hamachi, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2006, Peer-reviewed

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• Organic chemistry for creation and regulation of protein functions

  A Ojida; Y Miyahara; Hamachi, I

  JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, Feb. 2006, Peer-reviewed

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• Design and synthesis of bis(Zn(II)-dipicolylamine)-based fluorescent artificial chemosensors for phosphorylated proteins/peptides

  A Ojida; Hamachi, I

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Jan. 2006, Peer-reviewed

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• Ratiometric fluorescence detection of a tag fused protein using the dual-emission artificial molecular probe

  Kei Honda; Eiji Nakata; Akio Ojida; Itaru Hamachi

  CHEMICAL COMMUNICATIONS, 2006, Peer-reviewed

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• Bis(Dpa-Zn-II) appended xanthone: Excitation ratiometric chemosensor for phosphate anions

  Akio Ojida; Hiroshi Nonaka; Yoshifumi Miyahara; Shun-ichi Tamaru; Kazuki Sada; Itaru Hamachi

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, Peer-reviewed

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• Label-free, real-time glycosyltransferase assay based on a fluorescent artificial chemosensor

  J Wongkongkatep; Y Miyahara; A Ojida; Hamachi, I

  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, Peer-reviewed

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• Lectin functionalization by organic chemistry - Development of glycol-biosensor using P-PALM -

  Y. Koshi; E. Nakata; M. Miyagawa; I. Hamachi

  Polymer Preprints, Japan, 2006, Peer-reviewed

  
• Three distinct read-out modes for enzyme activity can operate in a semi-wet supramolecular hydrogel

  S Tamaru; S Kiyonaka; Hamachi, I

  CHEMISTRY-A EUROPEAN JOURNAL, Dec. 2005, Peer-reviewed

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• Cyclophane-lectin conjugates as a new class of water-soluble host

  O Hayashida; Hamachi, I

  JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY, Oct. 2005, Peer-reviewed

  
• Cyclophane-lectin conjugates as a new class of water-soluble host

  Osamu Hayashida; Itaru Hamachi

  Journal of Inclusion Phenomena, Oct. 2005, Peer-reviewed

  
• Double-modification of lectin using two distinct chemistries for fluorescent ratiometric sensing and imaging saccharides in test tube or in cell

  E Nakata; Y Koshi; E Koga; Y Katayama; Hamachi, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2005, Peer-reviewed

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• Synthesis and guest-binding study of polytopic multi(cyclophane) hosts

  O Hayashida; Y Takaoka; Hamachi, I

  TETRAHEDRON LETTERS, Sep. 2005, Peer-reviewed

  
• Globular self-aggregates formed with a urea-functionalized resorcinarene derivative in chloroform

  O Hayashida; S Matsumoto; Hamachi, I

  CHEMISTRY LETTERS, Sep. 2005, Peer-reviewed

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• Cooperation between artificial receptors and supramolecular hydrogels for sensing and discriminating phosphate derivatives

  S Yamaguchi; L Yoshimura; T Kohira; S Tamaru; Hamachi, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2005, Peer-reviewed

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• Luminescent saccharide biosensor by using lanthanide-bound lectin labeled with fluorescein

  Y Koshi; E Nakata; Hamachi, I

  CHEMBIOCHEM, Aug. 2005, Peer-reviewed

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• Suzuki coupling for protein modification

  A Ojida; H Tsutsumi; N Kasagi; Hamachi, I

  TETRAHEDRON LETTERS, May 2005, Peer-reviewed

  
• Simple and practical semi-wet protein/peptide array utilizing a micelle-mixed agarose hydrogel

  S Tamaru; S Yamaguchi; Hamachi, I

  CHEMISTRY LETTERS, Mar. 2005, Peer-reviewed

  
• pH-Responsive shrinkage/swelling of a supramolecular hydrogel composed of two small amphiphilic molecules

  SL Zhou; S Matsumoto; HD Tian; H Yamane; A Ojida; S Kiyonaka; Hamachi, I

  CHEMISTRY-A EUROPEAN JOURNAL, Feb. 2005, Peer-reviewed

  
• Preparation and unique circular dichroism phenomena of urea-functionalized self-folding resorcinarenes bearing chiral termini through asymmetric hydrogen-bonding belts

  O Hayashida; J Ito; S Matsumoto; Hamachi, I

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2005, Peer-reviewed

  
• Semisynthetic Proteins Bearing Tailor-made Functions

  HAMACHI Itaru; TSUTSUMI Hiroshi

  Kobunshi, 01 Jan. 2005

  
• Molecular recognition in a supramolecular hydrogel to afford a semi-wet sensor chip

  Yoshimura, I; Y Miyahara; N Kasagi; H Yamane; A Ojida; Hamachi, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Oct. 2004, Peer-reviewed

  
• Phosphoprotein-selective recognition and staining in SDS-PAGE by bis-Zn(II)-dipycolylamine-appended anthracene

  A Ojida; T Kohira; Hamachi, I

  CHEMISTRY LETTERS, Aug. 2004, Peer-reviewed

  
• Urea-functionalized resorcinarenes: Preparation, self-folding, and their CD phenomena caused by chiral urea termini through intramolecular hydrogen bonding interactions

  O Hayashida; J Ito; S Matsumoto; Hamachi, I

  CHEMISTRY LETTERS, Aug. 2004, Peer-reviewed

  
• Fluorophore appended saccharide cyclophane: Self-association, fluorescent properties, heterodimers with cyclodextrins, and cross-linking behavior with peanut agglutinin of dansyl-modified saccharide cyclophane

  O Hayashida; Hamachi, I

  JOURNAL OF ORGANIC CHEMISTRY, May 2004, Peer-reviewed

  
• A FRET study of guest delivery to concanavaline A by supramolecular hosts composed of an adamantyl-appended cyclophane and saccharide-branched cyclodextrins

  O Hayashida; Hamachi, I

  CHEMISTRY LETTERS, May 2004, Peer-reviewed

  
• Molecular recognition and fluorescence sensing of monophosphorylated peptides in aqueous solution by bis(zinc(II)-dipicolylamine)-based artificial receptors

  A Ojida; Y Mito-oka; K Sada; Hamachi, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2004, Peer-reviewed

  
• Coupling a natural receptor protein with an artificial receptor to afford a semisynthetic fluorescent biosensor

  E Nakata; T Nagase; S Shinkai; Hamachi, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jan. 2004, Peer-reviewed

  
• Semi-wet peptide/protein array using supramolecular hydrogel

  S Kiyonaka; K Sada; Yoshimura, I; S Shinkai; N Kato; Hamachi, I

  NATURE MATERIALS, Jan. 2004, Peer-reviewed

  
• Recognition and fluorescence sensing of specific amino acid residue on protein surface using designed molecules

  A Ojida; Y Miyahara; T Kohira; Hamachi, I

  BIOPOLYMERS, 2004, Peer-reviewed

  
• Visualization of muscarinic acetylcholine receptor using post-photoaffinity labeling modification (P-PLAM) method in cells

  S Kiyonaka; M Nishida; J Fuchimoto; I Hamachi; Y Mori

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2004

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• pH-responsive phase transition of supramolecular hydrogel consisting of glycosylated amino acetate and carboxylic acid derivative

  S Kiyonaka; SL Zhou; Hamachi, I

  SUPRAMOLECULAR CHEMISTRY, Oct. 2003, Peer-reviewed

  
• Cross-linking strategy for molecular recognition and fluorescent sensing of a multi-phosphorylated peptide in aqueous solution

  A Ojida; M Inoue; Y Mito-oka; Hamachi, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 2003, Peer-reviewed

  
• Construction of artificial signal transducers on a lectin surface by post-photoaffinity-labeling modification for fluorescent saccharide biosensors

  T Nagase; E Nakata; S Shinkai; Hamachi, I

  CHEMISTRY-A EUROPEAN JOURNAL, Aug. 2003, Peer-reviewed

  
• New supramolecular approach for saccharide-directed chemical modification of Concanavalin A

  O Hayashida; Hamachi, I

  CHEMISTRY LETTERS, Jul. 2003, Peer-reviewed

  
• Molecular recognition by supramolecular hosts composed of an adamantyl-appended macrocycle with cyclodextrins in water

  O Hayashida; Hamachi, I

  CHEMISTRY LETTERS, Mar. 2003, Peer-reviewed

  
• Combinatorial library of low molecular-weight organo- and hydrogelators based on glycosylated amino acid derivatives by solid-phase synthesis

  S Kiyonaka; S Shinkai; Hamachi, I

  CHEMISTRY-A EUROPEAN JOURNAL, Feb. 2003, Peer-reviewed

  
• Caged RNase: Photoactivation of the enzyme from perfect off-state by site-specific incorporation of 2-nitrobenzyl moiety

  T Hiraoka; Hamachi, I

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Jan. 2003, Peer-reviewed

  
• Site-specific discrimination by cyanovirin-N for alpha-linked trisaccharides comprising the three arms of Man(8) and Man(9)

  CA Bewley; S Kiyonaka; Hamachi, I

  JOURNAL OF MOLECULAR BIOLOGY, Sep. 2002, Peer-reviewed

  
• First thermally responsive supramolecular polymer based on glycosylated amino acid

  S Kiyonaka; K Sugiyasu; S Shinkai; Hamachi, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 2002, Peer-reviewed

  
• Efficient fluorescent ATP-sensing based on coordination chemistry under aqueous neutral conditions

  A Ojida; S Park; Y Mito-oka; Hamachi, I

  TETRAHEDRON LETTERS, Aug. 2002, Peer-reviewed

  
• First artificial receptors and chemosensors toward phosphorylated peptide in aqueous solution

  A Ojida; Y Mito-oka; M Inoue; Hamachi, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 2002, Peer-reviewed

  
• Semisynthetic hemoproteins using cofactor engineering: Toward supramolecular protein-based photosynthetic system

  S Tsukiji; Hamachi, I

  SUPRAMOLECULAR CHEMISTRY, Apr. 2002, Peer-reviewed

  
• Supramolecular construction of covalently and noncovalently-linked photoinduced electron transfer systems in myoglobin scaffold

  H Takashima; YZ Hu; K Sano; S Shinkai; S Oishi; Hamachi, I

  ELECTROCHEMISTRY, Dec. 2001, Peer-reviewed

  
• Zn(II) dipicolylamine-based artificial receptor as a new entry for surface recognition of alpha-helical peptides in aqueous solution

  Y Mito-Oka; S Tsukiji; T Hiraoka; N Kasagi; S Shinkai; Hamachi, I

  TETRAHEDRON LETTERS, Oct. 2001, Peer-reviewed

  
• Solid-phase lipid synthesis (SPLS)-2: incidental discovery of organogelators based on artificial glycolipids

  Hamachi, I; S Kiyonaka; S Shinkai

  TETRAHEDRON LETTERS, Aug. 2001, Peer-reviewed

  
• Nano-engineering of Proteins

  HAMACHI Itaru

  Kobunshi, 01 May 2001

  
• Pd(en) as a sequence-selective molecular pinch for alpha-helical peptides

  Hamachi, I; N Kasagi; S Kiyonaka; T Nagase; Y Mito-oka; S Shinkai

  CHEMISTRY LETTERS, Jan. 2001, Peer-reviewed

  
• Post-photoaffinity labeling modification using aldehyde chemistry to produce a fluorescent lectin toward saccharide-biosensors

  T Nagase; S Shinkai; Hamachi, I

  CHEMICAL COMMUNICATIONS, 2001, Peer-reviewed

  
• A general semisynthetic method for fluorescent saccharide-biosensors based on a lectin

  Hamachi, I; T Nagase; S Shinkai

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 2000, Peer-reviewed

  
• Direct comparison of electron transfer properties of two distinct semisynthetic triads with non-protein based triad: Unambiguous experimental evidences on protein matrix effects

  YZ Hu; H Takashima; S Tsukiji; S Shinkai; T Nagamune; S Oishi; Hamachi, I

  CHEMISTRY-A EUROPEAN JOURNAL, Jun. 2000, Peer-reviewed

  
• Guest-induced umpolung on a protein surface: A strategy for regulation of enzymatic activity

  Hamachi, I; R Eboshi; J Watanabe; S Shinkai

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, May 2000, Peer-reviewed

  
• Coupling covalent and noncovalent electron transfer in a catenane-type donor-sensitizer-acceptor triad

  YZ Hu; S Tsukiji; S Shinkai; S Oishi; H Durr; Hamachi, I

  CHEMISTRY LETTERS, May 2000, Peer-reviewed

  
• Novel saccharide-induced conformational changes in a boronic acid-appended poly(L-lysine) as detected by circular dichroism and fluorescence

  H Kobayashi; K Nakashima; E Ohshima; Y Hisaeda; Hamachi, I; S Shinkai

  JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, May 2000, Peer-reviewed

  
• Construction of artificial photosynthetic reaction centers on a protein surface: Vectorial, multistep, and proton-coupled electron transfer for long-lived charge separation

  YZ Hu; S Tsukiji; S Shinkai; S Oishi; Hamachi, I

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jan. 2000, Peer-reviewed

  
• The synthesis of a reconstituted C-60-modified protein

  H Murakami; Y Okusa; S Kiyonaka; Hamachi, I; S Shinkai; N Nakashima

  CHEMISTRY LETTERS, Jan. 2000, Peer-reviewed

  
• Solid phase lipid synthesis (SPLS) for construction of an artificial glycolipid library

  Hamachi, I; S Kiyonaka; S Shinkai

  CHEMICAL COMMUNICATIONS, 2000, Peer-reviewed

  
• Cyclodextrin-appended myoglobin as a tool for construction of a donor-sensitizer-acceptor triad on a protein surface

  Hamachi, I; H Takashima; YZ Hu; S Shinkai; S Oishi

  CHEMICAL COMMUNICATIONS, 2000, Peer-reviewed

  
• Metal-induced conformational changes in calix[n]arenes can control the electron-transfer efficiency between porphyrin and [60]fullerene in an on-off manner

  M Kawaguchi; A Ikeda; Hamachi, I; S Shinkai

  TETRAHEDRON LETTERS, Nov. 1999, Peer-reviewed

  
• Electron transfer from Zn-protoporphyrin IX to ruthenium ammine attached at His63 of reconstituted cytochrome b562

  Hamachi, I; H Takashima; S Tsukiji; S Shinkai; T Nagamune; S Oishi

  CHEMISTRY LETTERS, Jul. 1999, Peer-reviewed

  
• Direct observation of the ferric-porphyrin cation radical as an intermediate in the phototriggered oxidation of ferric- to ferryl-heme tethered to Ru(bpy)(3) in reconstituted myoglobin

  Hamachi, I; S Tsukiji; S Shinkai; S Oishi

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 1999, Peer-reviewed

  
• A convenient synthesis of a Ru(bpy)(3)-based catenane-type triad and its incorporation into a protein scaffold

  YZ Hu; S Tsukiji; S Shinkai; Hamachi, I

  CHEMISTRY LETTERS, Jun. 1999, Peer-reviewed

  
• Design and semisynthesis of spermine-sensitive ribonuclease S

  Hamachi, I; Y Yamada; R Eboshi; T Hiraoka; S Shinkai

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, May 1999, Peer-reviewed

  
• Single- or dual-mode switching of semisynthetic ribonuclease S ' with an iminodiacetic acid moiety in response to the copper(II) concentration

  Hamachi, I; Y Yamada; T Matsugi; S Shinkai

  CHEMISTRY-A EUROPEAN JOURNAL, May 1999, Peer-reviewed

  
• Facile preparation of robust organic gels by cross-link of a sugar-integrated gelator by toluene-2,4-diisocyanate

  K Inoue; Y Ono; Y Kanekiyo; S Kiyonaka; Hamachi, I; S Shinkai

  CHEMISTRY LETTERS, Mar. 1999, Peer-reviewed

  
• Chemical modification of the structures and functions of proteins by the cofactor reconstitution method

  Hamachi, I; S Shinkai

  EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, Mar. 1999, Peer-reviewed

  
• Ru(bpy)(3)-based artificial receptors toward a protein surface: selective binding and efficient photoreduction of cytochrome C

  H Takashima; S Shinkai; Hamachi, I

  CHEMICAL COMMUNICATIONS, 1999, Peer-reviewed

  
• A boronic acid-diol interaction is useful for chiroselective transcription of the sugar structure to the Delta- versus Lambda-[Co-III(bpy)(3)](3+) ratio

  T Mizuno; M Takeuchi; Hamachi, I; K Nakashima; S Shinkai

  JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, Oct. 1998, Peer-reviewed

  
• Design and semisynthesis of photoactive myoglobin bearing ruthenium tris(2,2 '-bipyridine) using cofactor-reconstitution

  Hamachi, I; S Tanaka; S Tsukiji; S Shinkai; S Oishi

  INORGANIC CHEMISTRY, Aug. 1998, Peer-reviewed

  
• Photoswitching of the enzymatic activity of semisynthetic ribonuclease S ' bearing phenylazophenylalanine at a specific site

  Hamachi, I; T Hiraoka; Y Yamada; S Shinkai

  CHEMISTRY LETTERS, Jun. 1998, Peer-reviewed

  
• Pyrenylboronic acids as a novel entry for photochemical DNA cleavage: diradical-forming pyrene-1,6-diyldiboronic acid mimics the cleavage mechanism of enediyne antitumor antibiotics

  H Suenaga; K Nakashima; T Mizuno; M Takeuchi; Hamachi, I; S Shinkai

  JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, Apr. 1998, Peer-reviewed

  
• Design and synthesis of a transition metal responsive semisynthetic myoglobin-bearing iminodiacetic acid moiety

  Hamachi, I; T Matsugi; K Wakigawa; S Shinkai

  INORGANIC CHEMISTRY, Apr. 1998, Peer-reviewed

  
• Incorporation of an artificial receptor into a native protein: New strategy for the design of semisynthetic enzymes with allosteric properties

  Hamachi, I; T Nagase; Y Tajiri; S Shinkai

  BIOCONJUGATE CHEMISTRY, Nov. 1997, Peer-reviewed

  
• Protein engineering using molecular assembly: Functional conversion of cytochrome c via noncovalent interactions

  Hamachi, I; A Fujita; T Kunitake

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Oct. 1997, Peer-reviewed

  
• Photocontrol of the redox state of ruthenium-tris(bipyridine)-appended cytochrome b(562)

  Hamachi, I; S Tanaka; S Tsukiji; S Shinkai; M Shimizu; T Nagamune

  CHEMICAL COMMUNICATIONS, Sep. 1997, Peer-reviewed

  
• Chiroselective transcription of the sugar structure to Delta- or Lambda-[Co-III(bpy)(3)](3+) using a boronic acid sugar template interaction

  T Mizuno; M Takeuchi; Hamachi, I; K Nakashima; S Shinkai

  CHEMICAL COMMUNICATIONS, Sep. 1997, Peer-reviewed

  
• Design and synthesis of sugar-responsive semiartificial myoglobin triggered by modulation of apoprotein-cofactor interactions

  Hamachi, I; Y Tajiri; T Nagase; S Shinkai

  CHEMISTRY-A EUROPEAN JOURNAL, Jul. 1997, Peer-reviewed

  
• A novel sugar sensing system designed with a cooperative action of a boronic-acid-appended zinc porphyrin and a 3-pyridylboronic acid axial ligand

  M Takeuchi; H Kijima; Hamachi, I; S Shinkai

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Mar. 1997, Peer-reviewed

  
• Transition-metals facilitated electron transfer of semisynthetic myoglobin bearing bis(iminodiacetic acid) moiety

  Hamachi, I; T Matsugi; S Shinkai

  TETRAHEDRON LETTERS, Dec. 1996, Peer-reviewed

  
• Sugar-enhanced aniline hydroxylase activity of semisynthetic myoglobins possessing m-dihydroxyborylphenylalanine

  Hamachi, I; T Nagase; Y Tajiri; S Shinkai

  CHEMICAL COMMUNICATIONS, Sep. 1996, Peer-reviewed

  
• Facilitated photoreduction of ruthenium bis(4'-methylterpyridine) pendant myoglobin

  Hamachi, I; T Matsugi; S Tanaka; S Shinkai

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Jun. 1996, Peer-reviewed

  
• Efficient photogeneration of oxidizing (compound II-like) species of semisynthetic myoglobin appending ruthenium tris(2,2'-bipyridine)

  Hamachi, I; S Tsukiji; S Tanaka; S Shinkai

  CHEMISTRY LETTERS, 1996, Peer-reviewed

  
• Sugar-induced chiral orientation of boronic-acid-appended amphiphile clusters formed in the dipalmitoylphosphatidylcholine (DPPC) membrane

  T Kimura; M Takeuchi; Hamachi, I; S Shinkai

  ISRAEL JOURNAL OF CHEMISTRY, 1996, Peer-reviewed

  
• ANILINE-HYDROXYLASE ACTIVITY OF MYOGLOBIN BY COUPLING WITH A MEMBRANE-BOUND ELECTRON-TRANSPORT SYSTEM

  HAMACHI, I; A FUJITA; T KUNITAKE

  CHEMISTRY LETTERS, Aug. 1995, Peer-reviewed

  
• PEROXIDASE-ACTIVITY OF CYTOCHROME-C GENERATED BY PHENYLBORONIC ACID MODIFICATION

  HAMACHI, I; O KIMURA; H TAKESHITA; S SHINKAI

  CHEMISTRY LETTERS, Jul. 1995, Peer-reviewed

  
• X-ray Crystallographic Studies of a Mn(Ⅱ)-bridged Biscalix[4]arene with a Large Inner Cavity

  H. Iki; H. Tsuzuki; H. Kijima; I. Hamachi; S. Shinkai

  Supramolecular Chimistry, 1995, Peer-reviewed

  
• NOVEL CHEMICAL MODIFICATION OF MYOGLOBIN BY AN ALCOHOL-RESPONSIVE PHENYLBORONIC ACID FUNCTION

  T NAGASAKI; O KIMURA; HAMACHI, I; S SHINKAI

  CHEMISTRY LETTERS, Oct. 1994, Peer-reviewed

  
• SUGAR-RESPONSIVE SEMISYNTHETIC MYOGLOBIN BEARING PHENYLBORONIC ACID GROUPS AS RECOGNITION SITES

  HAMACHI, I; Y TAJIRI; S SHINKAI

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 1994, Peer-reviewed

  
• ENHANCED PEROXIDASE-ACTIVITY OF CYTOCHROME-C BY PHOSPHATE BILAYER-MEMBRANE

  A FUJITA; H SENZU; T KUNITAKE; HAMACHI, I

  CHEMISTRY LETTERS, Jul. 1994, Peer-reviewed

  
• SELF-SUFFICIENT ELECTRON INJECTION FROM NADH TO THE ACTIVE-CENTER OF FLAVIN-PENDANT MYOGLOBIN

  HAMACHI, I; K NOMOTO; S TANAKA; Y TAJIRI; S SHINKAI

  CHEMISTRY LETTERS, Jun. 1994, Peer-reviewed

  
• SUGAR SENSING UTILIZING AGGREGATION PROPERTIES OF BORONIC-ACID-APPENDED PORPHYRINS AND METALLOPORPHYRINS

  H MURAKAMI; T NAGASAKI; HAMACHI, I; S SHINKAI

  JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, May 1994, Peer-reviewed

  
• SUGAR-FACILITATED INCORPORATION OF A HEME COFACTOR BEARING PHENYLBORONIC ACID GROUPS INTO APOMYOGLOBIN

  HAMACHI, I; Y TAJIRI; H MURAKAMI; S SHINKAI

  CHEMISTRY LETTERS, Mar. 1994, Peer-reviewed

  
• SYNTHESIS, METAL-BINDING PROPERTIES AND POLYPEPTIDE SOLUBILIZATION OF CROWNED ARBOROLS

  T NAGASAKI; O KIMURA; M UKON; HAMACHI, I; S SHINKAI; S ARIMORI

  JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, Jan. 1994, Peer-reviewed

  
• FUNCTIONAL CONVERSION OF HEMOPROTEINS BY SYNTHETIC BILAYER-MEMBRANES .4. ENHANCED N-DEMETHYLASE ACTIVITY OF CYTOCHROME-C BOUND TO A PHOSPHATE-BEARING SYNTHETIC BILAYER-MEMBRANE

  HAMACHI, I; A FUJITA; T KUNITAKE

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Sep. 1994, Peer-reviewed

  
• LIGHT-DRIVEN ACTIVATION OF RECONSTITUTED MYOGLOBIN WITH A RUTHENIUM TRIS(2,2'-BIPYRIDINE) PENDANT

  HAMACHI, I; S TANAKA; S SHINKAI

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Nov. 1993, Peer-reviewed

  
• SUGAR SENSING UTILIZING AGGREGATION PROPERTIES OF A BORONIC-ACID-APPENDED PORPHYRIN

  H MURAKAMI; T NAGASAKI; HAMACHI, I; S SHINKAI

  TETRAHEDRON LETTERS, Sep. 1993, Peer-reviewed

  
• ENERGY-TRANSFER FROM ZINC-MYOGLOBIN TO A CYANINE DYE FACILITATED BY THEIR SIMULTANEOUS BINDING TO A PHOSPHATE BILAYER-MEMBRANE

  HAMACHI, I; H FUJIMURA; T KUNITAKE

  CHEMISTRY LETTERS, Sep. 1993, Peer-reviewed

  
• RECONSTITUTION OF MYOGLOBIN WITH A HEME COFACTOR BEARING A RUTHENIUM TRIS(2,2'-BIPYRIDINE) PENDANT

  HAMACHI, I; S TANAKA; S SHINKAI

  CHEMISTRY LETTERS, Aug. 1993, Peer-reviewed

  
• LIPID ANCHORED MYOGLOBIN .2. EFFECT OF THE ANCHOR STRUCTURE ON MEMBRANE-BINDING

  HAMACHI, I; S HIGUCHI; K NAKAMURA; H FUJIMURA; T KUNITAKE

  CHEMISTRY LETTERS, Jul. 1993, Peer-reviewed

  
• ANISOTROPIC INCORPORATION OF LIPID-ANCHORED MYOGLOBIN INTO A PHOSPHOLIPID-BILAYER MEMBRANE

  HAMACHI, I; K NAKAMURA; A FUJITA; T KUNITAKE

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jun. 1993, Peer-reviewed

  
• SIMULTANEOUS FIXATION OF ORIENTATION OF MYOGLOBIN AND METALLOPORPHYRINS BY SYNTHETIC BILAYER-MEMBRANE

  HAMACHI, I; S NODA; H IWASAKI; T KUNITAKE

  PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES, Apr. 1992, Peer-reviewed

  
• FUNCTIONAL CONVERSION OF MYOGLOBIN BOUND TO SYNTHETIC BILAYER-MEMBRANES - FROM DIOXYGEN STORAGE PROTEIN TO REDOX ENZYME

  HAMACHI, I; S NODA; T KUNITAKE

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Dec. 1991, Peer-reviewed

  
• IMMOBILIZATION OF MYOGLOBIN IN A MULTILAYER FILM OF 2-DIMENSIONAL POLYMER NETWORK

  HAMACHI, I; H FUJIMURA; T KUNITAKE

  CHEMISTRY LETTERS, Dec. 1991, Peer-reviewed

  
• A NOVEL TRANSMEMBRANE ELECTRON CHANNEL CONTAINING FLAVIN UNITS

  Y KOBUKE; M YAMANISHI; HAMACHI, I; H KAGAWA; H OGOSHI

  JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, Jul. 1991, Peer-reviewed

  
• ORIENTED INTERCALATION OF MYOGLOBIN INTO MULTILAYERED FILMS OF SYNTHETIC BILAYER-MEMBRANES

  HAMACHI, I; T HONDA; S NODA; T KUNITAKE

  CHEMISTRY LETTERS, Jul. 1991, Peer-reviewed

  
• LAYERED ARRANGEMENT OF ORIENTED MYOGLOBINS IN CAST FILMS OF A PHOSPHATE BILAYER-MEMBRANE

  HAMACHI, I; S NODA; T KUNITAKE

  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Aug. 1990, Peer-reviewed

  
• Coupled electron-proton transport in flavolipid functionalized liposome

  Y. Kobuke; I. Hamachi

  Journal of the Chemical Society - Series Chemical Communications, 15 Sep. 1989, Peer-reviewed

  
• SYNTHESIS OF SIDE-CHAIN DERIVATIVES OF 2,2'-BIPYRIDINE

  L DELLACIANA; HAMACHI, I; TJ MEYER

  JOURNAL OF ORGANIC CHEMISTRY, Mar. 1989, Peer-reviewed

  
• ARTIFICIAL FLAVOLIPID - ITS SYNTHESIS, INCORPORATION INTO LIPOSOMAL MEMBRANE, ELECTRON-TRANSPORT, AND SUCCESSFUL CONTROL OF TRANSPORT RATE

  TABUSHI, I; HAMACHI, I; Y KOBUKE

  JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, Mar. 1989, Peer-reviewed

  
• Facilitated electron transfer from NADH to flavolipid bound in ammonium bilayer

  I. Hamachi; Y. Kobuke

  Journal of the Chemical Society, Chemical Communications, 1989, Peer-reviewed

  
• Polymerization of bilayer membranes and their cast films.

  Hamachi Itaru; Kunitake Toyoki

  Kobunshi, 1989

  
• EFFICIENT ELECTRON FLUX CONVERSION FROM STRONGLY HYDROPHILIC NADH MODEL IN THE TRANSMEMBRANE ELECTRON-TRANSFER BY FLAVOLIPID

  HAMACHI, I; Y KOBUKE; TABUSHI, I

  BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, Oct. 1988, Peer-reviewed

  
• CONTROL OF ELECTRON-TRANSPORT BY THERMALLY INDUCED PHASE-TRANSITION OF LIPOSOMAL MEMBRANE

  TABUSHI, I; HAMACHI, I; Y KOBUKE

  TETRAHEDRON LETTERS, 1987, Peer-reviewed

  
• SINGLE WALL BILAYER LIPOSOME FUNCTIONALIZED WITH THE ARTIFICIAL FLAVOLIPID(II) - ITS EFFICIENT ELECTRON FLUX CONVERSION FROM NADH MODEL OF AN APPROPRIATE STRUCTURE IN THE TRANSMEMBRANE ELECTRON-TRANSFER

  TABUSHI, I; HAMACHI, I

  TETRAHEDRON LETTERS, 1987, Peer-reviewed

  
• 1ST MEMBER OF ARTIFICIAL FLAVOLIPID FAMILY, ITS SYNTHESIS AND INCORPORATION INTO ARTIFICIAL LIPOSOMES

  TABUSHI, I; HAMACHI, I

  TETRAHEDRON LETTERS, 1986, Peer-reviewed

  
• ERYTHROSELECTIVITY IN ADDITION OF GAMMA-SUBSTITUTED ALLYLSILANES TO ALDEHYDES IN THE PRESENCE OF TITANIUM CHLORIDE

  T HAYASHI; K KABETA; HAMACHI, I; M KUMADA

  TETRAHEDRON LETTERS, 1983, Peer-reviewed

  
• Screening of protein-ligand interactions under crude conditions by native mass spectrometry

  Kotaro Takano; Shunsuke Arai; Seiji Sakamoto; Hiroshi Ushijima; Takahisa Ikegami; Kazumi Saikusa; Tsuyoshi Konuma; Itaru Hamachi; Satoko Akashi

  Analytical and Bioanalytical Chemistry, Jul. 2020, Peer-reviewed

  
• Construction of a Fluorescent Screening System of Allosteric Modulators for the GABA_A Receptor Using a Turn-On Probe.

  Sakamoto S; Yamaura K; Numata T; Harada F; Amaike K; Inoue R; Kiyonaka S; Hamachi I

  ACS central science, Sep. 2019, Peer-reviewed

  
• Heme-Transfer Mechanism of Structurally Similar Isd NEAT Domains of Staphylococcus Aureus Exhibiting Different Affinities for Heme

  Moriwaki Y; Terada T; Caaveiro JMM; Takaoka Y; Hamachi I; Tsumoto K; Shimizu K

  Biophysical Journal, 28 Jan. 2014, Peer-reviewed

  
• 芳香族-金属イオン間の直接的な相互作用に伴う蛍光レシオ変化を応用したカドミウム(II)イオンの細胞内蛍光イメージング

  高嶋 一平; 木下 実由紀; 中川 彩佳; 杉本 学; 浜地 格; 王子田 彰夫

  日本薬学会年会要旨集, Mar. 2013

  
• 2PT151 Computational and experimental studies on heme-binding and heme-transport mechanisms of Isd proteins of Staphylococcus aureus(The 50th Annual Meeting of the Biophysical Society of Japan)

  Moriwaki Yoshitaka; Terada Tohru; Caaveiro Jose M. M.; Takaoka Yousuke; Hamachi Itaru; Tsumoto Kouhei; Shimizu Kentaro

  Seibutsu Butsuri, 2012

  
• Development of chemokine receptor cxcr4 antagonists using bio-mimetic strategy

  H. Tamamura; T. Tanaka; H. Tsutsumi; N. Ohashi; K. Hiramatsu; T. Araki; A. Ojida; I. Hamachi; Z. Wang; S.C. Peiper; J.O. Trent; S. Ueda; S. Oishi; N. Fujii

  Advances in Experimental Medicine and Biology, 2009, Peer-reviewed

  
• Supramolecular semi-wet protein array - A new method for the immobilization of the proteins utilizing a hydrogel

  S Tamaru; Hamachi, I

  KOBUNSHI RONBUNSHU, 2004, Peer-reviewed

  

Misc.

• 4価型人工ペプチドを用いたホスファチジン酸結合プローブの開発

  小川 莉奈; 長尾 耕治郎; 原 雄二; 田村 朋則; 浜地 格; 井上 飛鳥; 青木 淳賢; 高橋 美帆; 西川 喜代孝; 梅田 真郷

  脂質生化学研究, May 2015

  
• 核内生体分子センシングのための核局在性蛍光プローブの開発

  中村彰伸; 滝川和正; 石田学; 桑田啓子; 中山忠親; 浜地格; 築地真也

  日本化学会講演予稿集, 2014

  
• Strategies of Protein Functionalization for Protein-Based Biosensors

  UCHINOMIYA Shohei; HAMACHI Itaru

  ぶんせき, 05 Dec. 2010

  Access this misc :

  
• 超分子化学的手法によるタンパク質工学

  浜地 格

  酵素工学研究会講演会講演要旨集, 22 Apr. 2005

  
• ヘムタンパク質の超分子化学 (特集/生体機能性化学の最前線)

  笠置 典之; 浜地 格

  化学工業, Jun. 2002

  
• Synthesis and Property of Metal lon-Responsive Reconstituted Hemoglobin

  Hamachi I.; Wakigawa K.; Matsugi T.; Shinkai S.; Imai K.

  Biophysics, 07 Sep. 1998

  
• 受容体活性化型TRPC3チャネル選択的拮抗剤の開発及び薬理学的応用

  森泰生; 清中茂樹; 加藤賢太; 西田基宏; 三尾和弘; 佐藤主税; 浜地格

  日本薬学会年会要旨集, 2009

  
• Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound

  清中茂樹; 加藤賢太; 西田基宏; 三尾和弘; 佐藤主税; 浜地格; 森泰生

  日本化学会講演予稿集, 2009

  
• 新規TRPC3チャネル阻害剤の開発及び作用機序の解明

  清中茂樹; 清中茂樹; 加藤賢太; 西田基宏; 三尾和弘; 澤口諭一; 沼田朋大; 佐藤主税; 浜地格; 浜地格; 森泰生; 森泰生

  生化学, 2009

  
• Supramolecular Hydrogel as Novel Biomaterials

  HAMACHI Itaru

  高分子学会予稿集, 04 Sep. 2007

  
• 解説記事 多様な化合物群の中からナノバイオ材料を創る

  清中 茂樹; 周 善来; 浜地 格

  未来材料, Jan. 2003

  
• 分子イメージングの新ステージ--細胞有機化学による斬新な化学プローブ分子の誕生

  高岡 洋輔; 築地 真也; 浜地 格

  化学, Jul. 2009

  
• 半合成タンパク質--タンパク質と有機合成化合物から構成されたサイボーグタンパク質 (特集1 マテリアルサイエンスで活躍するタンパク質(part2))

  本田 圭; 浜地 格

  バイオインダストリー, Nov. 2005

  
• モジュール法を用いる糖鎖誘導体の合成とその分子集合超構造

  清中 茂樹; 浜地 格; 新海 征治

  表面, May 2001

  
• タンパク質の特異的ラベリングと検出 (特集 生命化学とバイオ計測)

  高岡 洋輔; 浜地 格

  未来材料, Jun. 2007

  
• Toward photo-driven water splitting using chemically-modified myoglobin

  TSUKIJI Shinya; HAMACHI Itaru

  バイオサイエンスとインダストリー = Bioscience & industry, 01 Apr. 2002

  
• Development of a Protein Labeling Method Using Small Molecular Probes

  OJIDA Akio; NONAKA Hiroshi; HAMACHI Itaru

  Bioscience & industry, 01 May 2010

  
• Supramolecular Hydrogel as Semi-wet Material

  吉井 達之; 浜地 格

  機能材料, Mar. 2012

  
• 1C17-3 Semi-wet protein array and protein engineering using supramolecular hydrogel

  YAMAGUCHI Satoshi; TAMARU Shun-ichi; MATSUMOTO Shinji; HAMACHI Itaru

  日本生物工学会大会講演要旨集, 2005

  
• Supramolecular Chemistry of Proteins-Molecular Interface for Biomacromolecules-

  HAMACHI Itaru

  化学と工業 = Chemistry and chemical industry, 01 Feb. 1996

  
• Post-assembly Fabrication of a Functional Multicomponent Supramolecular Hydrogel Based on a Self-Sorting Double Network

  Wataru Tanaka; Hajime Shigemitsu; Takahiro Fujisaku; Ryou Kubota; Saori Minami; Kenji Urayama; Itaru Hamachi

  Journal of the American Chemical Society, 27 Mar. 2019

  
• 生体金属動態の分子科学-「生命金属科学」への展開 コンディショナルプロテオミクスによる亜鉛関連タンパク質群の同定

  田村 朋則; 三木 卓幸; 西川 雄貴; 清中 茂樹; 若林 真樹; 石濱 泰; 浜地 格

  生命科学系学会合同年次大会, Dec. 2017

  
• Fluorescence Sensing of Inorganic Phosphate and Pyrophosphate Using Small Molecular Sensors and Their Applications

  Jirarut Wongkongkatep; Akio Ojida; Itaru Hamachi

  Topics in Current Chemistry, 01 Apr. 2017

  
• コンディショナルプロテオミクスによる亜鉛関連タンパク質群の同定

  田村朋則; 三木卓幸; 西川雄貴; 清中茂樹; 若林真樹; 石濱泰; 浜地格; 浜地格

  日本生化学会大会(Web), 2017

  
• 新規conditionalプロテオミクスによる亜鉛関連タンパク質群の同定

  西川雄貴; 三木卓幸; 清中茂樹; 若林真樹; 石濱泰; 浜地格; 浜地格

  日本生化学会大会(Web), Sep. 2016

  
• Detection and Imaging of Protein Activity with Dynamic Self-Assembling Turn-on Nanoprobes

  TAKAOKA Yousuke; HAMACHI Itaru

  高分子, 01 Jun. 2013

  
• Development of a novel ROS sensing probe to visualize oxidative tumor microenvironment

  Keisuke Inoue; Shigeki Kiyonaka; Taketoshi Kajimoto; Itaru Hamachi; Yasuo Mori

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2011

  
• Development of a novel ROS sensing probe to visualize inflammatory macrophages

  Keisuke Inoue; Shigeki Kiyonaka; Itaru Hamachi; Yasuo Mori

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2010

  Access this misc :

  
• Ratiometric Imaging of Cadmium Ion Using A Novel Fluorescent Sensor Based on 7-Amino-4-methylcoumarin

  Masayasu Taki; Akio Ojida; Itaru Hamachi; Yukio Yamamoto

  14th International Conference on Biological Inorganic Chemistry (ICBIC XIV), Nagoya, Japan, Jul. 2009

  
• Engineering of endogenous protein by ligand-directed tosyl chemistry: Construction of a 19F NMR biosensor in live cells

  Yousuke Takaoka; Shinya Tsukiji; Itaru Hamachi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2009

  
• ORGN 362-Semitemplated collagen-like heterodimer: A potential method for tag-fused protein recognition

  Nicolas Delsuc; Akio Ojida; Itaru Hamachi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2009

  
• Selective protein labeling using reactive-tag system

  Hiroshi Nonaka; Shohei Uchinomiya; Shohei Fujishima; Akio Ojida; Itaru Hamachi

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2009

  
• Ratiometric Fluorescence Imaging of Intracellular Cadmium Using a Coumarin-based Chemosensor.

  Shohei Iyoshi; Masayasu Taki; Akio Ojida; Itaru Hamachi; Yukio Yamamoto

  The 4th Asian Biological Inorganic Chemistry Conference (AsBIC IV), Jeju, Korea, Nov. 2008

  
• A novel pyrazole derivative selectively inhibits TRPC3 channel.

  Kenta Kato; Shigeki Kiyonaka; Motohiro Nishida; Masakazu Ishi; Emiko Mori; Takuro Numaga; Takashi Yoshida; Takafumi Miki; Tsutomu Kobayashi; Takashi Morii; Itaru Hamachi; Minoru Wakamori; Yasuo Mori

  JOURNAL OF PHARMACOLOGICAL SCIENCES, 2007

  
• Smart biomaterials (6): Supramolecular hydrogel controls the rotation of motor protein at a single molecular level

  山口哲志; 松本真治; 石塚康司; 田端和仁; 新田英之; 藤田博之; 野地博行; 浜地格

  日本化学会講演予稿集, 13 Mar. 2006

  
• Synthesis of new supramolecular polymers based on glycosylated amino acid and their applications

  Srinivasulu Reddy Krishna Mohan; Itaru Hamachi

  Current Organic Chemistry, 2005

  
• Development of Artificial Molecules for Specific Recognition and Modification of Protein Surfaces

  INOUE Masa-aki; HAMACHI Itaru

  Journal of the Surface Science Society of Japan, 10 Dec. 2004

  
• 1.\tEquipment of Artificial Receptor with a Lectin by P-PALM for Construction of Fluorescent Oligosaccharide –Biosensors

  Eiji Nakata; Tsuyoshi Nagase; Seiji Shinkai; Itaru Hamachi

  Biomolecular Chemistry Proc. ISBC 2003, pp. 288-289, 2003., 2003, Peer-reviewed

  
• A New Approach to Design of Biomaterials for the Next Century

  HAMACHI Itaru; KIYONAKA Shigeki

  生体材料, 10 Jun. 2000

  
• LAYERED ARRANGEMENT OF ORIENTED HEMEPROTEINS IN CAST FILMS OF SYNTHETIC BILAYER-MEMBRANES

  HAMACHI, I; S NODA; T KUNITAKE

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Apr. 1991

  
• 内在性サイトカイン受容体のケミカルラベルによる生細胞イメージング

  高岡洋輔; 高岡洋輔; 高岡洋輔; 高岡洋輔; 高岡洋輔; 内之宮祥平; 小林大地; 林隆弘; 福山嘉明; 早坂晴子; 宮坂昌之; 上田卓見; 嶋田一男; 浜地格

  日本生化学会大会(Web), Sep. 2016

  
• Development of Chemically Reactive Supramolecular Hydrogel -Molecular Design and Function-

  Tatsuyuki Yoshii; Itaru Hamachi

  Kagaku to Seibutsu, 2015, Peer-reviewed, Invited

  
• In cell NMRに向けた化学-生物学的アプローチ

  高岡洋輔; 浜地格

  生体の科学, 2014

  
• Selective Chemical Labeling and Imaging of Endogenous Protein in Live Cells

  Itaru Hamachi

  BIOPOLYMERS, May 2013

  
• 革新的ケミカルプローブによるバイオセンシング 1: 自己会合性ナノプローブによる酵素活性Turn-Onイメージング

  松尾 和哉; 福山 嘉晃; 鎌田 瑠泉; 水澤 圭吾; 今井 宏彦; 高山 裕生; 楢崎 美智子; 松田 哲也; 高岡 洋輔; 浜地 格

  日本化学会第93回春季年会, Mar. 2013

  
• 刺激応答性“超分子ナノメッシュ”を用いた生体分子の運動制御

  松本真治; 山口哲志; 青木裕之; 伊藤紳三郎; 浜地格; 石塚康司; 伊香裕子; 田端和仁; 野地博行; 新田英之; 藤田博之

  高分子学会予稿集(CD-ROM), 04 Sep. 2007

  
• 超分子スマートマテリアルの創製(2):光応答性超分子ヒドロゲルの開発とナノバイオ材料としての展開

  松本真治; 山口哲志; 石塚康司; 伊香祐子; 田端和仁; 新田英之; 青木裕之; 伊藤紳三郎; 藤田博之; 野地博行; 浜地格

  日本化学会講演予稿集, 12 Mar. 2007

  
• Development of chemokine receptor CXCR4 antagonists using bio-mimetic strategy

  H. Tamamura; T. Tanaka; H. Tsutsumi; N. Ohashi; K. Hiramatsu; T. Araki; A. Ojida; I. Hamachi; Z. Wang; S. C. Pelper; J. O. Trent; S. Ueda; S. Oishi; N. Fujii

  BIOPOLYMERS, 2007

  
• 二核亜鉛錯体構造を有する新規ケモカインレセプターCXCR4アンタゴニストの創製

  OGAWA TEPPEI; TAMAMURA HIROKAZU; OJIDA AKIO; TSUTSUMI HIROSHI; NAKASHIMA HIDEKI; OISHI SHIN'YA; ONO HIROAKI; HAMACHI ITARU; FUJII NOBUTAKA

  メディシナルケミストリーシンポジウム講演要旨集, 10 Nov. 2006

  
• 『D4-タグ / 小分子プローブ』ペアを利用したタンパク質の蛍光イメージング

  本田 圭; 王子田 彰夫; 中田 栄司; 新見 大輔; 清中 茂樹; 森 泰夫; 浜地 格

  バイオイメージング, 31 Oct. 2006

  
• 超分子ヒドロゲルのバイオテクノロジーへの展開

  山口哲志; 浜地格

  バイオサイエンスとインダストリー, 2006

  
• Novel semi‐wet materials‐(2): The Construction of A Fluorescent Lectin Chip

  ZHOU Shanlai; 山根裕樹; 中田栄司; 浜地格

  日本化学会講演予稿集, 11 Mar. 2005

  
• Organic chemistry on protein surface (1): Function of doubly modified Lectin by two distinct methods

  中田栄司; 古志洋一郎; 古賀絵里奈; 片山佳樹; 浜地格

  日本化学会講演予稿集, 11 Mar. 2005

  
• Organic chemistry on protein surface (3): Development of one‐pot site specific modification

  穴井孝浩; 笠置典之; 中田栄司; 浜地格

  日本化学会講演予稿集, 11 Mar. 2005

  
• Organic chemistry on protein surface (2): The lectin modification using by thio‐ester and ketone chemistry

  古志洋一郎; 竹本洋己; 中田栄司; 穴井孝浩; 浜地格

  日本化学会講演予稿集, 11 Mar. 2005

  
• Protein Functionalization Explored by Organic Chemistry. Creating Novel Biosensors out of Lectin Proteins.

  古志洋一郎; 中田栄司; 浜地格

  現代化学, 01 Feb. 2005

  
• 刺激応答性超分子ヒドロゲルを用いたF₁‐ATPaseの一分子レベルでの回転制御

  山口哲志; 松本真治; 石塚康司; 新田英之; 藤田博之; 野地博行; 浜地格; 浜地格

  酵素工学研究会講演会講演要旨集, 2005

  
• 光アフィニティーラベル化後修飾法によるレクチン型バイオセンサーの構築

  中田栄司; 古志洋一郎; 竹本洋己; 浜地格

  バイオ・高分子シンポジウム講演要旨集, 26 Jul. 2004

  
• Intoroduction of Artificial Molecular for Lectin by P-PALM

  古志洋一郎; 中田栄司; 竹本洋己; 浜地格

  日本化学会講演予稿集, 11 Mar. 2004

  
• Coupling P-PALM with chemical modification to construct a semisynthetic Lectin

  中田栄司; 古志洋一郎; 浜地格

  日本化学会講演予稿集, 11 Mar. 2004

  
• Molecular recognition toward phosphoate and its derivatives.

  Hamachi, I

  ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, Mar. 2004

  
• Construction of an enzyme‐like lectin using P‐PALM.

  古志洋一郎; 中田栄司; 竹本洋己; 浜地格

  生体機能関連化学シンポジウム講演要旨集, 01 Oct. 2003

  
• Polymer materials changing through nanotechnology. Protein as a nanomaterial.

  中田栄司; 浜地格

  工業材料, 01 Jun. 2003

  
• Taylor-Made Protein (2): Lectin Engineering by Post-Photoaffinity Labeling Modification

  竹本洋己; 清中茂樹; 中田栄司; 浜地格

  日本化学会講演予稿集, 03 Mar. 2003

  
• Taylor-Made Protein (1): Introduction of Artificial Sub-site to Lectin by P-PALM method

  中田栄司; 長瀬剛; 新海征治; 浜地格

  日本化学会講演予稿集, 03 Mar. 2003

  
• Semisynthetic Receptor: Introduction of Artifical Sub‐site to ConA by P‐PALM method

  中田栄司; 長瀬剛; 新海征治; 浜地格

  日本化学会講演予稿集, 10 Sep. 2002

  
• Lectin Engineering by Post‐Photoaffinity Labeling Modification (P‐PALM). (2): Highly Selective Oligosaccaride Sensing by Introduction of Artificial Sub‐Binding Site.

  中田栄司; 長瀬剛; 新海征治; 浜地格

  日本化学会講演予稿集, 11 Mar. 2002

  
• Highly Selective Oligosaccharide Sensing by PET‐type saccharide‐Biosensors Based on a Lectin.

  中田栄司; 長瀬剛; 浜地格; 新海征治

  生体機能関連化学シンポジウム講演要旨集, Sep. 2001

  
• Pd(en) as a sequence‐selective modulator for α‐helix conformation of peptides.

  笠置典之; 清中茂樹; 中田栄司; 浜地格; 新海征治

  生体機能関連化学シンポジウム講演要旨集, Sep. 2000

  
• The function of the palladium ethylenediamine complex as the peptide selective modulator.

  中田栄司; 山田康弘; 浜地格; 新海征治

  日本化学会講演予稿集, 15 Mar. 2000

  
• A binuclear Zinc complex recognizes α‐helix peptide.

  中田栄司; 浜地格; 新海征治

  日本化学会講演予稿集, 15 Mar. 2000

  
• Ruthenium tris‐bipyridyl complex as a new entry of the protein photolysis reagent.

  中田栄司; 築地真也; 浜地格; 新海征治

  日本化学会講演予稿集, 15 Mar. 1999

  

Presentations

• In-brain ligand directed chemistry of neurotransmitter receptors for imaging and proteomics

  Itaru Hamachi

  ISBC2024, 25 Apr. 2024, Invited

  
• 脳内有機化学への挑戦

  浜地 格

  生命化学研究のフロンティア2024, 06 Apr. 2024, Invited

  
• Chemical neurotransmitter receptors labeling and optical proteome mapping in live brain

  Tomonori Tamura; Itaru Hamachi

  Chemical Tools for Complex Biological Systems III, 28 Mar. 2024, Invited

  
• オルガネラ選択的な有機化学から細胞生物学へのアプローチ

  田村 朋則; 浜地 格

  日本化学会 第104春季年会, 18 Mar. 2024, Invited

  
• 非平衡過程を活用した生体機能分子の配列

  窪田 亮; 浜地 格

  日本化学会 第104春季年会, 18 Mar. 2024, Invited

  
• 生命の化学とは

  浜地 格

  杉本直己教授退職記念講演会, 02 Mar. 2024, Invited

  
• 神経伝達物質受容体を狙った脳内有機化学

  浜地 格

  有機合成化学研究所 第38回講演会, 24 Nov. 2023, Invited

  
• 動物脳内の受容体ケミカルラベルとその活用

  浜地 格

  第96回日本生化学会大会, 31 Oct. 2023, Invited

  
• Multi-component Supramolecular Hydrogels as Promising Biomaterials

  Itaru Hamachi

  UC San Diego - Kyoto University - KSAC Joint Research Symposium on Biomaterials and Biointerfaces, 10 Oct. 2023, Invited

  
• 生体分子夾雑の有機化学を目指して

  浜地 格

  東京大学化学生命工学専攻第16回ChemBioハイブリッドレクチャー, 25 Sep. 2023, Invited

  
• Design of multicomponent supramolecular hydrogel systens

  Itaru Hamachi

  The lecture at Wuhan University of Technology, 08 Aug. 2023, Invited

  
• Ligand-directed Neurotransmitter Labeling and its Proximal Proteomics in Live Brain

  Itaru Hamachi

  THE 13th INTERNATIONAL ACTIVITY BASED PROTEIN PROFILING MEETING, 18 Jul. 2023, Invited

  
• 脳内有機化学の開拓を目指して

  浜地 格

  九州大学大学院工学研究院応用化学部門（分子） 教室セミナー, 03 Jul. 2023, Invited

  
• Coordination chemistryで生命分子夾雑系の解析と制御に挑む

  浜地 格

  第４回錯体化学会フロンティアセミナー, 28 Jun. 2023, Invited

  
• タンパク質の構造・動態解析に資するケミカルラベル

  浜地 格

  日本顕微鏡学会第79回学術講演会, 27 Jun. 2023, Invited

  
• NEUROTRANSMITTER RECEPTORS LABELING AND IMAGING IN THE MOUSE BRAIN

  Itaru Hamachi

  FASEB SRC -The Optical Probes Conference: Discovery to Application-, 05 Jun. 2023, Invited

  
• ケミカルラベルで細胞、脳内を解析する分子技術

  浜地 格

  日本ケミカルバイオロジー学会第17回年会, 29 May 2023, Invited

  
• Neurotransmitter receptor labeling in live brain by ligand-directed chemistry

  Itaru Hamachi

  7th Gratama Workshop, 11 May 2023, Invited

  
• Chemical labeling/imaging of neurotransmitter receptors in the brain

  Itaru Hamachi

  Universität Hamburg-Kyoto University Join Symposium "Cellular mechanisms of learning and memory”, 14 Mar. 2023, Invited

  
• 創発と融合 Think out of the box:化学と生物学の狭間で

  浜地 格

  JST創発自発的な融合の場 第1回分子生命反応創発討論会, 21 Feb. 2023, Invited

  
• Ligand-directed Chemical Labeling of Neurotransmitter Receptors in Cell and Live Brain

  Itaru Hamachi

  4th Asian Conference on Chemosensors & Imaging Probes, 07 Feb. 2023, Invited

  
• Think out of the box:化学生物学からの１事例

  浜地 格

  第45回日本分子生物学会年会, 01 Dec. 2022, Invited

  
• Chemical labeling of neurotransmitter receptors in live mice brain

  浜地 格

  第45回日本分子生物学会年会, 30 Nov. 2022, Invited

  
• ケミカルラベルで細胞、脳内を覗く分子技術

  浜地 格

  名古屋大学生命農学研究科 公開セミナー, 15 Nov. 2022, Invited

  
• Ligand-directed protein modification in live cell and live brain

  Itaru Hamachi

  Yonsei University department symposium, 10 Nov. 2022, Invited

  
• Ligand directed chemistry for receptors labeling in live systems

  Itaru Hamachi

  BASF discovery virtual symposium, 08 Nov. 2022, Invited

  
• 分子夾雑を目指すchemical biologyと超分子化学

  浜地 格

  第25回発動分子科学セミナー, 28 Oct. 2022, Invited

  
• ノーベル賞解説講演：クリック反応の開発と生体直行性有機化学への展開

  浜地 格

  第12回CSJ化学フェスタ, 18 Oct. 2022, Invited

  
• 分子夾雑化学を基軸としたケミカルバイオロジー

  浜地 格

  慶應義塾大学薬学研究科大学院特別講義, 17 Oct. 2022, Invited

  
• Ligand-directed Chemistry of Protein in Live Cells and Brain

  Itaru Hamachi

  POSTECH Signature Conference 2022, 11 Oct. 2022, Invited

  
• 分子夾雑化学から生体金属への貢献？

  浜地 格

  新学術領域 生命金属科学 夏の合宿, 05 Sep. 2022, Invited

  
• Chemical labeling of neurotransmitter receptors in live mouse brain

  Itaru Hamachi

  NEURO2022, 01 Jul. 2022, Invited

  
• 蛋白質表面の化学修飾を基軸とした機能阻害

  浜地 格

  第436回 CBI 学会講演会, 22 Jun. 2022, Invited

  
• Chemical Labeling/Imaging of Neurotransmitter Receptors in Live Cell and Brain

  Itaru Hamachi

  27th American Peptide Symposium, 14 Jun. 2022, Invited

  
• Design of multicomponent supramolecular hydrogel systems

  Itaru Hamachi

  Online Lecture at MPI for Polymer Research, 07 Jun. 2022, Invited

  
• Chemical modification of native proteins in live systems and beyond

  Itaru Hamachi

  ACS Spring 2022 Meeting, 22 Mar. 2022, Invited

  
• Chemistry for selective modification of endogenous proteins in living systems

  Itaru Hamachi

  IMPRS-LM PhD Symposium, 23 Apr. 2021, Invited

  
• Bioorthogonal chemical modification of endogenous proteins and beyond

  Itaru Hamachi

  Ulsan National Institute of Science & Technology, 13 Apr. 2021, Invited

  
• Chemical labelling for control of endogenous protein in live cells

  Itaru Hamachi

  RSC Chemical Biology & Bio-Organic Group Forum, 07 Jan. 2021, Invited

  
• Analysis and Control of Proteins Function in Cells by Coordination Chemistry

  Itaru Hamachi

  Metals in Biology and Medicine :From Molecular Image to Drug Resistance, 10 Dec. 2020

  
• 分子夾雑の化学・超分子化学

  浜地 格

  2020年度ダイナミック・アライアンス合同ウェブ分科会, 27 Nov. 2020

  
• Protein organic chemistry in live cells and beyond

  Itaru Hamachi

  Xingda Lecture, 20 Nov. 2020, Invited

  
• Chemical modification of endogenous proteins in living systems

  Itaru Hamachi

  The 57th Japanese Peptide Symposium, 09 Nov. 2020

  
• バイオで日本を洗濯ぜよ！...ん？..

  浜地 格

  化学フェスタ第10回記念企画～化学版 関ケ原の合戦～, 20 Oct. 2020

  
• Protein Organic Chemistry in Live Cells/Neuron/Brain

  Itaru Hamachi

  RSC Desktop Seminar, 17 Sep. 2020, Invited

  
• 生体夾雑系のタンパク質有機化学が目指すもの

  浜地 格

  第五回ケムステVシンポジウム, 07 Jul. 2020

  
• 分子夾雑系でのタンパク質有機化学

  浜地 格

  有機合成化学研究所第34回講演会, 21 Nov. 2019

  
• Organic chemistry of biomolecules in live cells/tissues

  Itaru Hamachi

  The Forth A3 Roundtable Meeting on Chemical Probe Research Hub, 18 Nov. 2019

  
• 生細胞有機化学を基軸としたタンパク質その場解析のための分子技術

  浜地 格

  「分子技術」シンポジウム〜未来に続く、極限のものづくり〜, 15 Nov. 2019

  
• Chemical labeling of endogenous proteins in live cell conditions

  Itaru Hamachi

  The 2019 Cold Spring Harbor Asia Conference on Chemical Biology and Drug Discovery, 28 Oct. 2019, Invited

  
• 細胞夾雑系でのタンパク質有機化学に挑む

  浜地 格

  第9回CSJ化学フェスタ2019, 15 Oct. 2019

  
• Chemical protein labeling and beyond

  HAMACHI Itaru

  Bayer Life Science Workshop "Chemical Biology _ Jointly Exploring New Frontiers", 24 Sep. 2019, Invited

  
• タンパク質群動態解析のためのケミカルプロテオミクス

  濵地 格

  日本分析化学会第68年会, 11 Sep. 2019, Invited

  
• 細胞環境に依存した Proteome 解析の新手法

  濵地 格

  第19回日本蛋白質科学会年会 第71回日本細胞生物学会大会 合同年次大会, 25 Jun. 2019, Invited

  
• Imaging and Function of Self-sorted Supramolecular Fibers

  HAMACHI Itaru

  2019 US-Japan Polymer Symposium:- Macromolecules: Challenges and Opportunities for the 21st Century-, 19 Jun. 2019, Invited

  
• Selective protein modification by ligand-directed chemistry

  HAMACHI Itaru

  the 8th Chemical Protein Synthesis Meeting, 17 Jun. 2019, Invited

  
• Live cell protein labeling for conditional proteomics

  HAMACHI Itaru

  Nano/Bioscience International Symposium, 07 Jun. 2019, Invited

  
• Chemical labeling of endogenous proteins in live cells

  HAMACHI Itaru

  Chemical Tools for Complex Biological Systems II, 28 Apr. 2019, Invited

  
• Structure and Function of Multi-Component Supramolecular Hydrogels

  HAMACHI Itaru

  The 2019 MRS Spring Meeting & Exhibit, 22 Apr. 2019, Invited

  
• Chemical labeling of endogenous receptors in live neurons

  HAMACHI Itaru

  The 9th BRI International Symposium, 08 Mar. 2019, Invited

  
• Can Artificial Molecular Recognition Control of Protein Functions in Live Systems?

  HAMACHI Itaru

  Sixth Asian Summit Symposium on Supramolecular Chemistry, 16 Feb. 2019, Invited

  
• 細胞夾雑系の解析に資する分子技術

  濵地 格

  機能生物学セミナー, 21 Jan. 2019, Invited

  
• Protein Organic Chemistry under multi-molecular crowding biosystem

  濵地 格

  第19回CIMoSセミナー, 10 Jan. 2019, Invited

  
• Ligand-directed chemistry for selective protein labeling in live cells

  HAMACHI Itaru

  10th International Peptide Symposium, 03 Dec. 2018, Invited

  
• Chemical labeling of membrane-proteins for imaging and drug screening

  HAMACHI Itaru

  The 30 th Annual Meeting of the Thai Society for Biotechnology and International Conference, 22 Nov. 2018, Invited

  
• Live Cel Chemistry for Protein Imaging and Control.

  HAMACHI Itaru

  NYC Chem Bio Seminar, 31 Oct. 2018, Invited

  
• タンパク質を観る・操作する分子技術

  濵地 格

  第86回創薬科学セミナー, 16 Oct. 2018, Invited

  
• Ligand-directed chemistry for endogenous protein modification

  濵地 格

  第28回光学活性化合物シンポジウム, 12 Oct. 2018, Invited

  
• Chemical strategies for labeling and controlling neurotransmitter receptors

  HAMACHI Itaru

  AIAS Symposium: Cutting Edge Technologies for Neurobiology, 20 Sep. 2018, Invited

  
• 細胞機能をタンパク質分解能で解析・制御するための分子技術

  濵地 格

  第70回日本生物工学会大会, 05 Sep. 2018, Invited

  
• Chemical labeling of endogenous proteins for imaging and functional inhibition

  HAMACHI Itaru

  EMBO Workshop: Chemical Biology 2018, 29 Aug. 2018, Invited

  
• 分子夾雑系でのタンパク質有機化学

  濵地 格

  有機合成夏期セミナー「明日の有機合成化学」, 27 Aug. 2018, Invited

  
• Chemical endogenous protein labeling and its application in live systems

  HAMACHI Itaru

  The 5th Asian Chemical Biology Conference (ACBC-5), 20 Aug. 2018, Invited

  
• 分子夾雑の生命化学を目指して

  濵地 格

  2018年度京都バイオ計測センターシンポジウム バイオイノベーションに向けた新しい視点, 01 Aug. 2018, Invited

  
• 生細胞有機化学というChemical biology

  濵地 格

  第34回創薬セミナー, 11 Jul. 2018, Invited

  
• 膜蛋白質解析のための新しい化学ラべル化法

  濵地 格

  第18回日本蛋白質科学会年会 (朱鷺メッセ 新潟コンベンションセンター), 26 Jun. 2018, Invited

  
• Protein Chemistry in Multi-molecular Crowding Biosystems

  HAMACHI Itaru

  The 2nd International Symposium on Chemical Communication (Aobayama North Campus, Tohoku University, JAPAN), 28 May 2018, Invited

  
• 分子夾雑系のタンパク質有機化学

  濵地 格

  第28回万有福岡シンポジウム 躍動する機能性有機分子～この有機分子の力を見よ～ (九州大学・医学部百年講堂, 12 May 2018, Invited

  
• Challenge of Organic chemistry for multimolecular crowding biosystems

  HAMACHI Itaru

  日本化学会第98春季年会 (日本大学理工学部・船橋キャンパス), 20 Mar. 2018, Invited

  
• Imaging and control of neurotransmitter receptors in live cells

  HAMACHI Itaru

  Grand Challenges in Analyzing and Manipulating Cells on the Nanoscale (Max Planck Institute for Medical Research, GERMANY), 15 Mar. 2018, Invited

  
• Molecular Design of Functional Supramolecular Hydrogels

  HAMACHI Itaru

  2nd FRIMS International Symposium on Frontier Materials (Nagoya Institute of Technology, JAPAN), 01 Feb. 2018, Invited

  
• Functioal Supramolecular Hydrogels and Their Biological Applications

  HAMACHI Itaru

  ICOBAN2018 (City University of Hong Kong, CHINA), 09 Jan. 2018, Invited

  
• Chemcial Strategies for Endogenous Protein Labeling in Multimolecular Crowding Biosystems

  HAMACHI Itaru

  CMCB2017 (Kobe Portopia Hotel, JAPAN), 12 Dec. 2017, Invited

  
• 有機化学で細胞内のタンパク質の姿を見る

  濵地 格

  第21回VBLシンポジウム「見る、観る、診る技術の最先端 分子からヒトまで」(名古屋大学フロンティアプラザ), 21 Nov. 2017, Invited

  
• Live cell chemistry for neurotransmitter receptors

  HAMACHI Itaru

  6th Gratama Workshop in Chemical Sciences and Innovations for a Sustainable Society (Zernike Campus, University of Groningen, NETHERLANDS), 29 Oct. 2017, Invited

  
• 細胞表面で分子をつなぐ合成化学

  濵地 格

  第7回CSJ化学フェスタ2017 (タワーホール船堀), 17 Oct. 2017, Invited

  
• 投稿から出版まで

  濵地 格

  第7回CSJ化学フェスタ2017 (タワーホール船堀), 17 Oct. 2017, Invited

  
• 超分子材料からみた分子ロボティクス

  濵地 格

  新学術領域「分子ロボティクス」最終公開シンポジウム「分子ロボティクスの拓く未来」(東京大学・伊藤国際学術研究センター), 15 Jul. 2017, Invited

  
• 膜タンパク質のケミカルラベルとイメージング

  濵地 格

  第150回ポバール会 (京都大学・宇治おうばくプラザ・きはだホール), 01 Jul. 2017, Invited

  
• 分子夾雑系の化学とイメージング

  濵地 格

  第38回光化学若手の会 (休暇村志賀島), 16 Jun. 2017, Invited

  
• Chemistry of proteins labeling for deciphering their functions in live systems

  HAMACHI Itaru

  "Current Topics in Chemical Biology" at the KCS Spring Conference (Korean Chemical Society, KOREA), 20 Apr. 2017, Invited

  
• Protein responsive supramolecular assembly for live cell imaging

  HAMACHI Itaru

  ACS 253rd National Meeting (Moscone Center, San Francisco, U.S.A), 02 Apr. 2017, Invited

  
• Self-sorting超分子ファイバーの構築と機能

  濵地 格

  日本化学会第97春季年会 (慶應義塾大学・日吉キャンパス), 16 Mar. 2017, Invited

  
• Chemical Proteins Labeling for Deciphering Their Functions in Live Systems

  HAMACHI Itaru

  The 5th Asian Summit Symposium (Marriot Hotel, Sanya, Hainan Island, CHINA), 08 Jan. 2017, Invited

  
• Structure and Function of Hydrogels Comprising Self-Sorted Supramoleular Fibers

  HAMACHI Itaru

  2016 MRS Fall Meeting & Exhibit (Boston, Massachusetts, USA), 27 Nov. 2016, Invited

  
• Ligand-directed Chemistry for Protein Labeling and Imaging in Live Cell Systems

  HAMACHI Itaru

  International Conference on Single Cell Research 2016, 16 Nov. 2016, Invited

  
• Chemical method for labeling and imaging endogenous proteins in live cells

  HAMACHI Itaru

  Janelia Conforence on Fluorescent Proteins and Biological Sensors V (Janelia Research Campus, USA), 06 Nov. 2016, Invited

  
• Design and Function of Supramolecular Hydrogels

  HAMACHI Itaru

  IBS-CSC Conference (POSCO International Center, POSTECH, Pohang, KOREA), 24 Oct. 2016, Invited

  
• A new chemical genetic approach for controlling activity of membrane-bound receptor proteins in live cells

  HAMACHI Itaru

  1st A3 Roundtable Meeting on Chemical Probe Research Hub (Fukuoka, JAPAN), 22 Sep. 2016, Invited

  
• 選択的タンパク質修飾を基軸としたケミカルプロテオミクスの新手法

  濵地 格

  第29回バイオメディカル分析科学シンポジウム (京都大学・桂キャンパス), 02 Sep. 2016, Invited

  
• Design of Logic Gate Responsive Supramolecular Hydrogel

  HAMACHI Itaru

  MSMLG2016 (the University of Bath), 24 Jul. 2016, Invited

  
• Artificial Molecular Recognition Can Control the Function of Neurotransmitter Receptors in Live cells

  HAMACHI Itaru

  2016 IBS CONFERENCE (POSCO International Center, Pohang, KOREA), 15 Jul. 2016, Invited

  
• In-situ Real Time Imaging of Self-sorted Supramolecular Fibers

  HAMACHI Itaru

  ISMSC-2016 (The K-Hotel Seoul, KOREA), 10 Jul. 2016, Invited

  
• Real Time Imaging of Orthogonally Self-assembled Fibers

  HAMACHI Itaru

  2016 Japan-USA Seminar on Polymer Synthesis: -Polymer Synthesis for a Sustainable Future- (Hilton Niseko Village, Hokkaido, JAPAN）, 24 Jun. 2016, Invited

  
• 生細胞有機化学によるタンパク質その場解析の分子技術

  濵地 格

  平成28年前期(春季)有機合成化学講習会 (日本薬学会長井記念館長井記念ホール), 15 Jun. 2016, Invited

  
• Ligand-directed chemistry for protein labeling under crude biological systems

  HAMACHI Itaru

  EUCHEM Conference on Stereochemistry (Seehotel Waldstätterhof Brunnen, SWITZERLAND), 01 May 2016, Invited

  
• 膜蛋白質イメージングと機能制御のためのChemical Biology

  濵地 格

  酵素工学研究会第75回講演会 (京都大学・益川ホール), 22 Apr. 2016, Invited

  
• 刺激応答性自己組織化分子のバイオ機能創成

  濵地 格

  日本化学会第96春季年会 (同志社大学・京田辺キャンパス), 24 Mar. 2016, Invited

  
• 生細胞でのタンパク質の直接化学修飾法の開発と機能解析への展開

  濵地 格

  国際高等研究所プロジェクト「生命活動を生体高分子への修飾から俯瞰する」平成27年度研究会 (国際高等研究所), 08 Feb. 2016, Invited

  
• 生細胞でのタンパク質の構造・機能解析のための有機化学的アプローチ

  濵地 格

  理研「分子システム研究」平成27年度成果報告シンポジウム (理化学研究所・鈴木梅太郎ホール), 03 Feb. 2016, Invited

  
• Ligand-Directed Chemistry for Bioorthogonal Protein Labeling in Living System

  HAMACHI Itaru

  Pacifichem 2015 (Honolulu, Hawaii, U.S.A), 15 Dec. 2015, Invited

  
• 錯体化学の力も借りた生細胞化学

  濵地 格

  第53回錯体化学若手の会・近畿支部勉強会 (同志社大学・今出川キャンパス), 12 Dec. 2015, Invited

  
• New Chemical Methods for Labeling and Imaging Proteins in Live Cell

  HAMACHI Itaru

  New Advances in Optical Imaging of Live Cells and Organisms (Suzhou Dushu Lake Conference Center, CHINA), 07 Dec. 2015, Invited

  
• バイオマーカーに応答する超分子ヒドロゲル

  濵地 格

  有機合成化学研究所講演会(第30回) (京都大学・桂キャンパス), 24 Nov. 2015, Invited

  
• リガンド指向性化学による生細胞でのタンパク質修飾と解析

  濵地 格

  大塚 有機合成シンポジウム2015 (大塚製薬・徳島研究所), 19 Nov. 2015, Invited

  
• Protein-responsive Supramolecular Assembly for Live Cell Imaging

  HAMACHI Itaru

  Asian-ChIP 2015 (Stanford Hotel, Seoul, KOREA), 16 Nov. 2015, Invited

  
• リガンド指向性化学による生細胞での精密有機反応

  濵地 格

  第41回反応と合成の進歩シンポジウム (近畿大学・11月ホール), 26 Oct. 2015, Invited

  
• 膜蛋白質の生細胞有機化学と超分子化学

  濵地 格

  15-1バイオ・高分子研究会(秋保温泉 ホテルニュー水戸屋), 17 Sep. 2015, Invited

  
• Protein Responsive Supramolecules Acting as Live Imaging Tool in Live Cells

  HAMACHI Itaru

  4th International Supramolecular System Symposium (ISSS2015) (South Lake Hotel, Changchun, CHINA), 06 Sep. 2015, Invited

  
• Protein responsive supramolecular assembly for live cell imaging

  HAMACHI Itaru

  10th-ISMSC 2015 (Palais de Congrès, Strasbourg, FRANCE), 28 Jun. 2015, Invited

  
• 生細胞有機化学を基軸としたタンパク質解析のための新しい分子技術

  濵地 格

  新学術領域研究「天然物ケミカルバイオロジー～分子標的と活性制御～」第8回公開シンポジウム(東北大学片平キャンパス さくらホール), 08 Jun. 2015, Invited

  
• 生体夾雑系を指向した超分子化学の挑戦

  濵地 格

  第13回 ホスト・ゲスト化学シンポジウム HGCS2015(東北大学・川内北キャンパス), 06 Jun. 2015, Invited

  
• 生細胞有機化学によるタンパク質ラベル化とイメージング

  濵地 格

  第64回高分子学会年次大会(札幌コンベンションセンター), 27 May 2015, Invited

  
• タンパク質を標的とした生細胞有機化学

  濵地 格

  静岡県立大学 第243回月例薬学セミナー(静岡県立大学小講堂), 11 May 2015, Invited

  
• 生細胞有機化学を基軸としたタンパク質その場解析のための分子技術

  濵地 格

  日本化学会第95春季年会(日本大学・船橋キャンパス), 26 Mar. 2015, Invited

  
• タンパク質ラベリングを基盤とした生細胞有機化学

  濵地 格

  ERATO伊藤ｸﾞﾗｲｺﾄﾘﾛｼﾞｰﾌﾟﾛｼﾞｪｸﾄ終了シンポジウム「融合的アプローチによる生命現象の探求」(理化学研究所・和光研究所 大河内記念ホール), 23 Jan. 2015, Invited

  
• タンパク質の生細胞有機化学

  濵地 格

  高等研「分子基盤に基づく生体機能への揺らぎとダイナミックネットワークの解明」2014年度第1回研究会 (国際高等研究所), 14 Dec. 2014, Invited

  
• Ligand-directed Chemistry for Protein Labeling under Live Conditions

  HAMACHI Itaru

  15th Tetrahedron Symposium -Asian Edition (Singapore EXPO Convention and Exhibition Centre, SINGAPORE), 28 Oct. 2014, Invited

  
• Protein Organic Chemistry under Live Cell Conditions

  HAMACHI Itaru

  The Nagoya Medal of Organic Chemistry 2014 (Noyori Conference Hall, Nagoya University, JAPAN), 27 Oct. 2014, Invited

  
• Protein Organic Chemistry under Live Cell Conditions

  HAMACHI Itaru

  The 7th PKU-Eli Lilly Symposium of Organic Chemistry (Peking University, CHINA), 27 Sep. 2014, Invited

  
• 反応性超分子ヒドロゲルの開発と医療応用

  濵地 格

  “未来へのバイオ技術”勉強会 超分子＆ポリマーマテリアルと医療デバイス (バイオインダストリー協会), 10 Sep. 2014, Invited

  
• 内在性タンパク質のケミカルラベルによる生細胞での相互作用解析

  濵地 格

  第6回薬学の未来を考える京都シンポジウム「イメージング技術が切り開く創薬・病態研究の未来」 (京都大学・薬学部記念講堂), 02 Aug. 2014, Invited

  
• Chemical Strategies for Labeling and Manipulating Proteins in Live Cells

  HAMACHI Itaru

  Bioorthogonal Chemistry Meeting of the Division of Biochemistry (Harnack-Haus (Goethe-Saal), Berlin, GERMANY), 16 Jul. 2014, Invited

  
• 超分子ヒドロゲルの分子設計:セミウエット材料としての可能性

  濵地 格

  第74回SCCJ研究討論会 (大阪国際交流センター1F大ホール), 10 Jul. 2014, Invited

  
• Supramolecular Hydrogel as Unique Semi-wet Soft Materials

  HAMACHI Itaru

  NIMS Conference 2014 (Tsukuba International Congress Center, EPOCHAL TSUKUBA), 01 Jul. 2014, Invited

  
• Ligand-directed chemistry for endogenous protein labeling under live conditions

  HAMACHI Itaru

  15th Tetrahedron Symposium (Millennium Gloucester Hotel London Kensington, UK), 24 Jun. 2014, Invited

  
• Design of Fluorescent Chemosensors for Adenosine Tri-Phosphate (ATP)

  HAMACHI Itaru

  The 10th Korea-Japan Symposium on Frontier Photoscience - 2014 (Ewha Campus Complex, Ewha Womans University, Seoul, KOREA), 21 Jun. 2014, Invited

  
• Supramolecular Hydrogel as Novel Semi-wet Materials

  HAMACHI Itaru

  The 9th International Symposium on Macrocyclic and Supramolecular Chemistry (Shanghai Institute of Organic Chemistry, Shanghai, CHINA), 07 Jun. 2014, Invited

  
• Construction of Biosensors under Live Cell Conditions by Chemical Protein Labeling

  HAMACHI Itaru

  The 113th General Meeting of the Korean Chemical Society (KINTEX,Goyang, KOREA), 16 Apr. 2014, Invited

  
• 天然タンパク質をバイオプローブへ変換する生細胞化学

  濵地 格

  理研シンポジウム第9回「バイオものづくり」シンポジウム (理化学研究所・研究交流棟), 13 Mar. 2014, Invited

  
• ATPを標的とした蛍光プローブの設計と合成

  濵地 格

  第28回一般財団法人有機合成化学研究所講演会 (京都大学桂キャンパス・化学系大講義室), 05 Nov. 2013, Invited

  
• 蛋白質を基質とした生細胞有機化学の展開

  濵地 格

  第243回分子工学コロキウム (京大桂キャンパス), 01 Nov. 2013, Invited

  
• タンパク質解析のための生細胞でのケミカルラベリンク

  濵地 格

  第51回日本生物物理学会年会 (国立京都国際会館), 28 Oct. 2013, Invited

  
• 蛋白質応答性自己組織化ナノ集合体の構築

  濵地 格

  3研究領域合同公開シンポジウム (コクヨホール・東京ショールーム), 17 Oct. 2013, Invited

  
• Ligand-Directed Chemistry for Natural Proteins Under Living Conditions

  HAMACHI Itaru

  New trends of nano- or bio-materials design in supramolecular chemistry, 20 Sep. 2013, Invited

  
• 生細胞での化学プローブ／蛋白質の直接ハイブリッド化による機能化

  濵地 格

  化学工学会第45回秋季大会 (岡山大学), 16 Sep. 2013, Invited

  
• 内在性蛋白質のケミカルレベル化法の開発とイメージング

  濵地 格

  第22回日本バイオイメージング学会学術集会 (東京大学), 15 Sep. 2013, Invited

  
• Live Cell Endogenous Protein Labeling and Functional Analysis

  HAMACHI Itaru

  The 15th Asian Chemical Congress, 19 Aug. 2013, Invited

  
• Design of Fluorescent ATP Chemsensors Useful Under Living Cells

  HAMACHI Itaru

  8th International Symposium on Macrocyclic and Supramolecular Chemistry, 07 Jul. 2013, Invited

  
• 天然タンパク質を基質とした生細胞有機化学

  濵地 格

  25周年記念万有札幌シンポジウム未来を拓く創造有機化学 (北海道大学工学部オープンホール), 06 Jul. 2013, Invited

  
• 生細胞でのタンパク質有機化学の試み

  濵地 格

  第48回天然物化学談話会 (アヤハレークサイドホテル), 03 Jul. 2013, Invited

  
• Chemistry for Native Protein Labeling Under Live Conditions

  HAMACHI Itaru

  The 3rd Annual Symposium "Frontiers at the Chemistry-Biology Interface", 24 Jun. 2013, Invited

  
• Selective Chemical Labeling and Imaging of Endogenous Protein in Live Cells

  HAMACHI Itaru

  23rd American Peptide Symposium, 22 Jun. 2013, Invited

  
• 蛋白質ケミカルラベリングを基盤とした細胞有機化学

  濵地 格

  第13回日本蛋白質科学会年会 (とりぎん文化会館), 12 Jun. 2013, Invited

  
• 分子認識プローブによる蛋白質ラベリング／イメージング

  濵地 格

  第20回クロマトグラフィーシンポジウム (神戸大学・百年記念館), 05 Jun. 2013, Invited

  
• 特異的蛋白質イメージングを目指した自己会合型OFF/ONナノプローブの創製

  濵地 格

  CREST「プロセスインテグレーションに向けた高機能ナノ構造体の創出」領域第３回シンポジウム (コクヨホール・東京ショールーム), 04 Jun. 2013, Invited

  
• 生命化学の深化を目指した分子技術

  濵地 格

  日本化学会第93春季年会 (立命館大学びわこ・くさつキャンパス), 22 Mar. 2013, Invited

  
• 細胞夾雑系でのタンパク質合成化学

  濵地 格

  日本化学会第93春季年会 (立命館大学びわこ・くさつキャンパス), 22 Mar. 2013, Invited

  
• Self-assembled nanoprobes for selective protein imaging

  HAMACHI Itaru

  RSC Publishing-iCeMS Joint International Symposium "Cell-Material Integration and Biomaterials Science", 18 Mar. 2013, Invited

  
• 認識と反応のcouplingによる生細胞有機化学の展開

  濵地 格

  ナノ・バイオサイエンス研究センター start-up講演会 (同志社大学京田辺キャンパス), 02 Mar. 2013, Invited

  
• 分子プローブの開発と生体機能解析への応用

  濵地 格

  京都大学工学研究科 高等研究院・インテックセンター 平成24年度成果報告会 (京都大学桂キャンパス桂ホール), 23 Jan. 2013, Invited

  
• Self-assembled nano-probe for selective detection and imaging proteins

  HAMACHI Itaru

  The 9th SPSJ International Polymer Conference (Kobe Convention Center, JAPAN), 11 Dec. 2012, Invited

  
• Self-assembled Nanoparticle for Selective Protein Labeling and Imaging

  HAMACHI Itaru

  US-Japan Seminar on Polymer Synthesis (UC Santa Barbara, USA), 01 Dec. 2012

  
• Quantitative Comparison of Protein Dynamics in Live Cells and in vitro by In-Cell 19F-NMR

  Yousuke Takaoka; Itaru Hamachi

  International Joint Symposium on Single-Cell Analysis (Kyoto Research Park, JAPAN), 27 Nov. 2012

  
• Self-assembled Nanoprobes for Selective Protein labeling and Imaging

  HAMACHI Itaru

  6th Annual Symposium on Nanobiotechnology "Kyoto Cell-Material Integration 2012 (Shiran Kaikan, Kyoto University, JAPAN), 08 Nov. 2012

  
• 人生のヒントをもらった高校時代：化学と分子と生物の世界へ

  濵地 格

  糸島高校創立110周年記念講演会 (糸島高校), 27 Oct. 2012, Invited

  
• 超分子ヒドロゲルの構築と機能化

  濵地 格

  ゲルワークショップ イン 名古屋 (KKRホテル名古屋), 21 Sep. 2012, Invited

  
• Selective Protein Labeling Using Ligand-Directed Chemistry

  HAMACHI Itaru

  The 2nd Queenstown Chemical Biology and Drug Discovery Meeting (Rydges Hotel Queenstown, NEW ZEALAND), 26 Aug. 2012

  
• 内在性蛋白質のケミカルラベル化法の開発と展望

  濵地 格

  第7回未来創薬イノベーションセミナー (北海道大学), 08 Aug. 2012, Invited

  
• Supramolecular Hydrogels as Semi-wet Matrix for Sensor or Molecular Logic Devices

  HAMACHI Itaru

  MSMLG2012 (Korea University, KOREA), 08 Jul. 2012, Invited

  
• 蛋白質を基質と捉えた細胞系有機化学

  濵地 格

  理研シンポジウム 第7回有機合成化学のフロンティア (理化学研究所 鈴木梅太郎ホール), 06 Jul. 2012, Invited

  
• 細胞夾雑系で機能するタンパク質ラベル化分子

  濵地 格

  分子ロボティクス研究会6月月例会 (京都大学 吉田キャンパス 小林・益川記念室), 29 Jun. 2012, Invited

  
• Coupling Molecular Recognition with Reaction Toward Protein Labeling and Engineering

  HAMACHI Itaru

  Hamilton 60th Symposium (University of Oxford, UK), 24 Jun. 2012

  
• Self-assembling Nano-probe for Turn-on Detection of Selective Protein

  Itaru Hamachi; Yousuke Takaoka

  IACIS 2012 (Sendai International Center, Japan), 13 May 2012, Invited

  
• タンパク質ラベリングを基盤とする生細胞化学

  濵地 格

  日本化学会第92春季年会, 25 Mar. 2012, Invited

  
• セミウエットバイオ素子を目指した超分子ヒトケロゲル

  濵地 格

  日本化学会第92春季年会, 25 Mar. 2012, Invited

  
• Chemical Methods for Protein Labeling and Engineering under Live Cell Conditions

  HAMACHI Itaru

  2012 ACBI Hanoi meeting (Hanoi Deawoo Hotel, Vietnam), 24 Feb. 2012, Invited

  
• 蛋白質ケミカルラベリングを基軸とした細胞有機化学

  濵地 格

  第30回メディシナルケミストリーシンポジウム (タワーホール船堀), 2012

  
• 内在性蛋白質のケミカルラベル化と機能解析への応用

  濵地 格

  第85回日本生化学会大会 (福岡国際会議場・マリンメッセ福岡), 2012, Invited

  
• 膜蛋白質の選択的ケミカルラベル化とイメージングの新手法

  濵地 格

  有機合成化学研究所講演会(第26回), 24 Nov. 2011, Invited

  
• Protein labeling and engineering in live cell systems

  HAMACHI Itaru

  CIPSM - Fest of Chemical Biology, 15 Sep. 2011, Invited

  
• Live Cell Imaging And Labeling By Metal Complexes

  HAMACHI Itaru

  The 14th Asian Chemical Congress, 08 Sep. 2011, Invited

  
• 錯体化学を活用したバイオイメージング

  濵地 格

  第24回生物無機化学夏季セミナー, 29 Aug. 2011, Invited

  
• 分子デザインが拓くナノバイオテクノロジーの未来

  濵地 格

  崇城大学RENS企画第２回市民公開セミナー, 31 Jul. 2011, Invited

  
• 細胞有機化学による生細胞系そのままでの蛋白質Engineering

  濵地 格

  第21回バイオ・高分子シンポジウム, 25 Jul. 2011, Invited

  
• 生細胞での蛋白質の選択的ケミカルラベル化と機能化

  濵地 格

  新学術領域研究「過渡的複合体」公開シンポジウム, 21 Jul. 2011, Invited

  
• Dynamic nano-assembly for labeling native protein

  HAMACHI Itaru

  ISMSC2011, 03 Jul. 2011, Invited

  
• 蛋白質の有機化学の新展開：ラベリング、イメージング、エンジニアリング

  濵地 格

  第117回生物有機化学・草津セミナー, 24 Jun. 2011, Invited

  
• 細胞機能解析・制御のための超分子ナノ集合体の創成

  濵地 格

  CREST第1回公開シンポジウム 高機能ナノ構造体 分子の世界からマクロの世界へ, 15 Jun. 2011, Invited

  
• バイオ機能創出を目指した人工脂質ライブラリーの構築

  濵地 格

  久留米高度先端医療開発クラスター 研究テーマ連携セミナー, 14 Jun. 2011, Invited

  
• Chemical Labeling and Imaging of Protein in Live Cells

  HAMACHI Itaru

  IUPAC International Congress on Analytical Science 2011, 23 May 2011, Invited

  
• 超分子ヒドロゲルのバイオ素子への展開

  濵地 格

  日本化学会第91春季年会 (神奈川大学・横浜キャンパス), 26 Mar. 2011, Invited

  
• 生物無機化学から更なる境界領域へ:錯体化学を活用した Chemical Biology

  濵地 格

  日本化学会第91春季年会, 26 Mar. 2011, Invited

  
• A Chemistry-Based Method For Labering Membrane- Bound Proteins On Live Cell Surface

  HAMACHI Itaru

  The 5th International Workshop on Approaches to Single-Cell Analysis, 03 Mar. 2011

  
• New methods for Chemistry-based Protein Labeling in Live Cell

  濵地 格

  第4回高度医療都市を創出する未来技術国際シンポジウム, 08 Feb. 2011

  
• 細胞系での蛋白質ラベリングとイメージング

  濵地 格

  日本薬学会東海支部特別講演会, 20 Jan. 2011, Invited

  
• セミウエットバイオ材料としての超分子ヒドロゲル

  濵地 格

  第17回N2RC拠点セミナー, 12 Jan. 2011, Invited

  
• Self-assembled nano-probe for labeling and imaging endogenous protein in test tube and in live cell

  HAMACHI Itaru

  Pacifichem 2010, 15 Dec. 2010, Invited

  
• Chemistry-based protein labeling and imaging in cell and in vivo

  HAMACHI Itaru

  5th International Peptide Symposium, 04 Dec. 2010, Invited

  
• 細胞有機化学を目指した蛋白質の選択的修飾とイメージング

  濵地 格

  薬学会北陸地区特別講演会, 06 Nov. 2010, Invited

  
• Biomolecules Sensing and Imaging by Metal Complexes

  HAMACHI Itaru

  The 5th Asian Biological Inorganic Chemistry Conference, 01 Nov. 2010, Invited

  
• 夾雑系での合成化学 : 細胞有機化学を例に

  濵地 格

  第4回「ナノ組織化と機能シンポジウム」, 14 Sep. 2010, Invited

  
• Design of Supramolecular Hydrogels toward Biomaterials

  HAMACHI Itaru

  International Symposium on Supramolecular Chemistry, 11 Sep. 2010

  
• Chemistry-Based Methods for Selective Lectin Labeling

  HAMACHI Itaru

  25th international Carbohydrate Symposium2010, 01 Aug. 2010, Invited

  
• Glyocolipid Mimics as Supramolecular Hydrogel Biomaterials

  HAMACHI Itaru

  2010 International Symposium of Glycosciences, 29 Jul. 2010

  
• Protein Selective Labeling and Imaging by Chemistry

  HAMACHI Itaru

  1st Asian Chemical Biology Conference, 25 Jun. 2010

  
• 細胞での蛋白質選択的ケミカルラベルの新手法

  濵地 格

  第10回日本蛋白質科学会年会 (札幌コンベンションセンター), 16 Jun. 2010, Invited

  
• 化学を基盤とした新規タンパク質標識法とイメージング

  濵地 格

  第28回物性物理化学研究会 (京都大学・薬学部記念講堂), 04 Jun. 2010, Invited

  
• 錯体化学でケミカルバイオロジーする

  濵地 格

  第42回錯体化学若手の会 近畿地区勉強会, 29 May 2010, Invited

  
• Dynamic Properties of Supramolecular Hydrogel FIbers for Biomaterials Application

  HAMACHI Itaru

  4th Asian Summit Sympo on Supramolecular Chemistry, 12 May 2010, Invited

  
• 内在性蛋白質の選択的ラベル化とイメージング

  濵地 格

  日本化学会第90春季年会 (近畿大学), 26 Mar. 2010, Invited

  
• Selective Chemical Labeling and Engineering of Endogenous Proteins in Test Tube, in Cell and in Vivo

  HAMACHI Itaru

  International Symposium of Joint Research Network on Advanced Materials and Devices "Chou", 25 Mar. 2010

  
• 蛋白質表面化学から細胞内有機化学へ

  濵地 格

  第4回公開シンポジウム, 03 Mar. 2010, Invited

  
• セミウエットバイオ材料を目指した超分子ヒドロゲルナノ繊維の可能性

  濵地 格

  第4回SORSTシンポジウム「ナノ空間材料その特性と魅力」, 29 Jan. 2010, Invited

  
• タンパク質表面化学を鍵とした細胞内有機化学への展開

  濵地 格

  第9回東北大学多元物質科学研究所研究発表会, 10 Dec. 2009, Invited

  
• Supramolecular Hydrogels for Biomaterials Application

  HAMACHI Itaru

  2009 Gel symposium, 02 Dec. 2009, Invited

  
• 細胞内有機化学を目指した試行錯誤

  濱地 格

  第三回物質科学フロンティアセミナー「ものづくりを基盤とする最先端科学：分子の設計、創造、そして解明」 (名古屋大学・野依記念物質科学研究館), 30 Nov. 2009, Invited

  
• Organic Chemistry toward Protein Surface: in Test Tube and in Cell

  HAMACHI Itaru

  2009 China-Japan Symposium on Advanced Organic Chemistry, 27 Nov. 2009

  
• 超分子型プローブによる細胞内タンパク質ラベリングとイメージング

  濵地 格

  有機合成化学研究所講演会(第24回), 26 Nov. 2009, Invited

  
• 生体機能を探る人工プローブ創製を目指した化学的アプローチ

  濵地 格

  第9回放射性医薬品・画像診断薬研究会, 14 Nov. 2009, Invited

  
• GPCRへのプローブ導入のための化学ラベル化法

  濵地 格

  第82回日本生化学会, 21 Oct. 2009, Invited

  
• 超分子のソフトマテリアルとしての可能性

  濵地 格

  第９回高分子サロン, 09 Oct. 2009, Invited

  
• Fluorescent chemo- and Bio-sensor for substances of biological importance

  HAMACHI Itaru

  2009 Dalian symposium on sensing and imagin, 18 Sep. 2009

  
• Fluorescent Chemosensor for Phosphate Anion Derivatives of Biological Significance

  HAMACHI Itaru

  13th Asian Chemical Congress (International convention center, CHINA), 14 Sep. 2009, Invited

  
• Chemistry-based Protien Engineering in Test Tube, Cell Lysate, Cell and In vivo

  HAMACHI Itaru

  5th iCeMS International Symposium, 27 Jul. 2009

  
• バイオハイブリッド材料としての超分子ヒドロゲル

  濵地 格

  ＳＮＡＭＳシンポジウム (東北大学), 12 Jun. 2009

  
• 人工分子のハイブリッドによるタンパク質型バイオセンサーの構築

  濵地 格

  第9回日本蛋白質科学会年会 (熊本全日空ホテル), 22 May 2009, Invited

  
• 内在性タンパク質を標的とした細胞有機化学の展開

  濵地 格

  天然有機化合物討論会50周年記念講演会, 16 May 2009

  
• 生命化学の展望

  濵地 格

  甲南大学FIRST開所式シンポジウム, 09 May 2009

  
• 超分子ヒドロゲルによる生体分子の固定化と機能

  濵地 格

  高分子ポリマーネットワーク研究会講演会, 16 Apr. 2009

  
• Organic Chemistry for Proteins in Test Tube and In Vivo

  HAMACHI Itaru

  Yonsei mini-symposium on chemical biology, 02 Apr. 2009

  
• 夾雑系での有機化学：細胞有機化学を目指して

  濵地 格

  有機合成2月セミナー, 03 Feb. 2009

  
• Selective chemical labeling of a target protein in cell

  HAMACHI Itaru

  International Life Surveyor Symposium, 29 Jan. 2009

  
• バイオイメージングのための化学ツールの開発

  濵地 格

  生物工学会講演会, 17 Dec. 2008

  
• 蛋白質有機化学の新展開：試験管から細胞へ

  濵地 格

  白鷺セミナー, 15 Dec. 2008

  
• New Chemical Methods for Selective Protein Labeling

  HAMACHI Itaru

  BMB2008 (Kobe, JAPAN), 11 Dec. 2008, Invited

  
• タンパク質選択的ケミカルラベリングの新手法：レクチンを中心に

  濵地 格

  糖質科学フォーラム, 03 Dec. 2008

  
• 化学的手法を基盤としたタンパク質のラベル化と機能化

  濵地 格

  2008年度第2回機器分析センター研究会, 20 Nov. 2008

  
• New Chemical Methods for Protein Labeling

  HAMACHI Itaru

  2008 RIKEN Conference on Chemical Biology, 12 Nov. 2008

  
• 夾雑系の有機化学：細胞有機化学を目指した悪戦苦闘

  濵地 格

  東大化学生命専攻ChemBioハイブリッドレクチャー, 08 Nov. 2008

  
• Organic Chemistry toward Protein Surface

  HAMACHI Itaru

  3rd Asian Summit Symposium on Supramolecular Chemistry, 03 Nov. 2008

  
• Chemistry-based Protein Labeling

  HAMACHI Itaru

  22nd Naito Conference (Sapporo, JAPAN), 08 Sep. 2008, Invited

  
• 生命科学を加速する分子ツールの開発

  濵地 格

  第4回バイオ機器研究会, 08 Aug. 2008

  
• スマートバイオマテリアルとしての超分子ヒドロゲル

  濵地 格

  08-2 ポリマーフロンティア, 05 Jun. 2008

  
• Self-assembled semi-wet materials for nano-biotechnology

  HAMACHI Itaru

  2008 Bionano-sympo, Tokyo Tech Yokohama, 08 May 2008

  
• 細胞内分子解析のための化学ツールの創製

  濵地 格

  日本化学会第88春季年会, 26 Mar. 2008, Invited

  
• 自己組織化超分子ゲルの構築と機能

  濵地 格

  第9回リング・チューブ超分子研究会シンポジウム, 10 Dec. 2007

  
• 人工小分子によるタンパク質認識と反応

  濵地 格

  第3回バイオミメティクスシンポジウム, 08 Dec. 2007

  
• Novel Biosensors for Analyzing Substrates of Biological Significance

  Itaru Hamachi

  2007 Material Research Society (MRS) Fall meeting, 25 Nov. 2007, Invited

  
• Semi-wet Self-assembled Materials for Nanobio-science and technology

  HAMACHI Itaru

  6th JSPS France symposium, 22 Nov. 2007

  
• 超分子ヒドロゲルファイバーのバイオ機能

  濵地 格

  第56回高分子討論会, 19 Sep. 2007, Invited

  
• 生体機能を探るナノバイオセンサー

  濵地 格

  第56回分析科学討論会, 19 Sep. 2007, Invited

  
• Self-assembly for Biological Materials

  HAMACHI Itaru

  Crete Symposium on Self-assembly of Peptide and Proteins, 07 Jul. 2007

  
• Chemistry-based Protein Labeling

  HAMACHI Itaru

  1st Japan-Swiss Chemical Biology Symposium, 24 Jun. 2007

  
• タンパク質認識と変換のための有機化学

  濵地 格

  万有仙台シンポジウム, 23 Jun. 2007

  
• Molecular Recognition to Anionic Species of Biological Significance

  HAMACHI Itaru

  2nd Korean-Japan Summit, 16 Jun. 2007

  
• 超分子科学からケミカルバイオロジーへ

  濵地 格

  日本化学会第87春季年会, 25 Mar. 2007, Invited

  
• New Methods for Protein Labeling

  HAMACHI Itaru

  The 3rd International Chemical Biology Frontier Symposium, 22 Feb. 2007

  
• 超分子ヒドロゲルのバイオマテリアルへの展開

  濵地 格

  高分子ゲル研究会シンポジウム, 28 Nov. 2006, Invited

  
• 超分子ヒドロゲルによるバイオ材料創製

  濵地 格

  バイオマテリアル学会 (東京), 26 Nov. 2006, Invited

  
• Coordination Chemistry-based Protein Labeling

  HAMACHI Itaru

  4th Peptide Engineering Meeting, 05 Nov. 2006, Invited

  
• Semi-wet Supramolecular Biomaterials

  HAMACHI Itaru

  1st Korean-Japan Summit, 23 Sep. 2006

  
• タンパク質表面の認識変換とバイオ分析

  濵地 格

  バイオメディカル分析科学シンポジウム, 02 Aug. 2006, Invited

  
• Chemo- or bio-sensor for analyzing substrates of biological significance

  HAMACHI Itaru

  Uppasala Univ., 21 Jun. 2006

  
• 生体シグナル解析を目指したセンサー分子の創製

  濵地 格

  日本化学会第86春季年会特別企画, 27 Mar. 2006, Invited

  
• 蛋白質機能制御のための化学生物学的新手法の開発

  濵地 格

  日本化学会第86春季年会, 27 Mar. 2006, Invited

  
• 人工糖脂質ライブラリーからの生体機能マテリアル創製

  濵地 格

  生体機能関連化学部会講習会, 11 Mar. 2006

  
• ケミカルバイオロジーを支える分子ツールの創成

  濵地 格

  高峰コンファレンス, 18 Feb. 2006

  
• Semi-wet Supramolecular Materials for Nano-biotechnology

  HAMACHI Itaru

  Pacifichem 2005, 15 Dec. 2005, Invited

  
• Fluorescent Chemosensors for Phosphate Anion Derivatives of Biological Significance

  HAMACHI Itaru

  Pacifichem 2005, 15 Dec. 2005, Invited

  
• タンパク質表面有機化学から細胞有機化学を目指して

  濵地 格

  SORSTジョイントシンポジウム(4), 28 Nov. 2005

  
• セミウエット超分子材料のコンビナトリアル合成

  濵地 格

  第20回有機合成化学研究所講演会, 24 Nov. 2005

  
• 細胞機能解析を目指したセンシング・制御分子ツールの創製

  濵地 格

  第1回特定領域ライフサーベイヤシンポジウム, 17 Oct. 2005

  
• 蛋白質表面化学からのケミカルバイオロジー

  濵地 格

  中部地区化学連合秋季大会シンポジウム (静岡), 24 Sep. 2005, Invited

  
• 超分子化学で挑むケミカルバイオロジー

  濵地 格

  第1回分子情報ダイナミクス研究会, 07 Sep. 2005

  
• Molecular Recognition and Chemosensing toward Substances of Biological Significance

  HAMACHI Itaru

  11th Asian Chemical Congress, 24 Aug. 2005, Invited

  
• Semi-wet supramolecular hydrogel as nano-biometerials

  HAMACHI Itaru

  ICMAT2005, Singapore, 03 Jul. 2005, Invited

  
• Self-assembled nanofiber scaffold for peptide/protein arrays

  HAMACHI Itaru

  Fourth Multidisciplinary Workshop, 25 Jun. 2005

  
• 蛋白質表面有機化学を基盤にしたインテリジェントバイオデバイス

  濵地 格

  第3回ケモゲノミクス研究会, 25 May 2005

  
• 超分子化学的タンパク質工学

  濵地 格

  第51回酵素工学研究会, 22 Apr. 2005

  
• タンパク質・ペプチドの表面分子認識と蛍光センシング

  濵地 格

  第52回応用物理学会, 30 Mar. 2005, Invited

  
• 生命化学における科学・技術と次世代化学産業

  濵地 格

  日本化学会第85春季年会, 26 Mar. 2005, Invited

  
• Control of protein function by chemistry-based engineering

  HAMACHI Itaru

  JGFoS2004 sympo., 28 Jan. 2005

  
• 生体分子の化学と工学のための有機化学

  濵地 格

  理研シンポジウム第8回「生体分子の化学」, 14 Jan. 2005

  
• Supramolecular Strategy to Recognize and Immobilize Protein Molecules

  HAMACHI Itaru

  12th ISAM(The 12th International Symposium on Advanced Materials), 07 Dec. 2004

  
• Molecular recognition toward complex molecules of biological significance

  HAMACHI Itaru

  BSRI-CIMS Mini-Symposium on Molecular Recognition and Sensin, 26 Nov. 2004

  
• 生命化学における科学と技術

  濵地 格

  産学連携BICSシンポジウム（シリーズ 第一回〕, 22 Nov. 2004

  
• Semi-wet self-assembled materials for nano-biotechnology

  HAMACHI Itaru

  Nano-organization and Function, 11 Nov. 2004

  
• 金属錯体によるタンパク質・ペプチド表面分子認識：センシングと制御

  濵地 格

  分子研研究会「生体金属分子科学の展望」, 01 Oct. 2004

  
• Semi-wet Supramolecular Materials Obtained by Solid Phase Synthesis

  HAMACHI Itaru

  JCCF19(19th Conference on Combinatorial Chemistry), 13 Sep. 2004, Invited

  
• タンパク質・ペプチド表面分子認識：センシングと制御

  濵地 格

  日本化学会84春季年会 特別企画, 29 Mar. 2004, Invited

  
• Molecular Recognition toward Phosphate and its Derivatives

  HAMACHI Itaru

  227th American Chemical Society National Meeting, 27 Mar. 2004, Invited

  
• Supramolecular Hydrogel as Bio/nano-interface

  HAMACHI Itaru

  Indo-Japan Workshop on Advanced Molecular Electronics and Bionics, 11 Dec. 2003

  
• Semi-wet Peptide/Protein Array Using Supramolecular Hydrogel

  HAMACHI Itaru

  ISSIN-2003, 08 Dec. 2003

  
• Molecular Recognition to Phosphorylated Proteins Surface and Its Application

  HAMACHI Itaru

  KISPOC, 30 Sep. 2003

  
• Supramolecular Chemistry toward Protein Surface

  HAMACHI Itaru

  2nd 日韓天然物会議, 17 Sep. 2003

  
• バイオ分子を素材としたソフト機能材料の創出

  濵地 格

  応用物理学会秋年会, 30 Aug. 2003, Invited

  
• Protein/Peptide Recognition and Reaction by Artificial Receptors

  HAMACHI Itaru

  19th ICHC (International Congress of Heterocyclic Chemistry), 10 Aug. 2003, Invited

  
• 糖鎖検出・材料化のための新しい生命分子化学

  濵地 格

  グライコサイエンス若手の会, 07 Aug. 2003

  
• Regulation of protein function by molecular recognition

  HAMACHI Itaru

  PEM-III (3rd Pepitide Engineering Meeting), 15 Jul. 2003, Invited

  
• 超分子ライブラリーの構築とナノバイオ材料の探索

  濵地 格

  H15有機合成化学協会 講習会, 19 Jun. 2003

  
• Nano-engineering of Protein Surface

  HAMACHI Itaru

  第一回バイオ・ナノインターフェース国際会議, 20 May 2003

  
• Organic Chemistry toward Protein Surfaces

  HAMACHI Itaru

  日本化学会九州支部・韓国合同会議, 08 May 2003

  
• 分子の多様性に学ぶ生命分子化学

  濵地 格

  19回機能性ホスト・ゲスト研究会, 17 Mar. 2003

  
• 多様性の中からナノバイオ材料を創る

  濵地 格

  ナノテク支援公開講演会, 08 Mar. 2003

  
• Bioorganic Engineering of Native Proteins

  HAMACHI Itaru

  Dynamical Structures and Molecular Design of Metalloproteins, 18 Nov. 2002

  
• 亜鉛複核錯体によるタンパク質の認識

  濵地 格

  錯体ミニシンポ, 02 Oct. 2002, Invited

  
• Molecular Recognition on a Protein Surface

  HAMACHI Itaru

  BISBORM, 15 Aug. 2002

  
• Construction of Donor-Acceptor System on a Protein Surface

  HAMACHI Itaru

  GRC (Gordon Research Conference) on Electron Donor Acceptor Interactions, 11 Aug. 2002, Invited

  
• Supramolecular Chemistry toward Natural Protein Surface

  HAMACHI Itaru

  Kyushu Univ. COE Closing international symposium, 25 Jul. 2002

  
• Semisynthetic Hemoproteins by Cofactor Engineering

  HAMACHI Itaru

  6th International Porphyrin _ Heme Symposium in Association with 9th International SPACC Symposium, 06 Jul. 2002, Invited

  
• Modulation of Molecular Recognition on a Protein Surface

  HAMACHI Itaru

  GRC (Gordon Research Conference) on bioorganic chemistry, 09 Jun. 2002, Invited

  
• ナノバイオ材料としての人工タンパク質

  濵地 格

  医用高分子研ナノバイオマテリアルシンポ, 22 Nov. 2001

  
• 高分子有機無機化学としての蛋白質エンジニアリング

  濵地 格

  東海・生命機能勉強会, 14 Nov. 2001

  
• Organic Chemistry toward Natural Proteins

  HAMACHI Itaru

  Nagoya Conference, 12 Nov. 2001

  
• タンパク質を機能材料化する化学的アプローチ

  濵地 格

  ペプチド科学フォーラム, 02 Nov. 2001

  
• Engineering Artificial Photoreaction Center Based on Hemoprotein

  HAMACHI Itaru

  Kochi / CREST international symposium, 01 Aug. 2001

  
• 糖鎖分析・材料化を目指した生物有機化学の新戦略

  濵地 格

  糖鎖学会シンポ, 01 Aug. 2001, Invited

  
• 金属錯体を用いたタンパク質光化学特性の制御

  濵地 格

  配位化合物の光化学討論会, 30 Jul. 2001, Invited

  
• Semisynthetic Receptors and Biosensors

  HAMACHI Itaru

  Pre-ISMC Conference, 13 Jul. 2001

  
• Switching Enzymatic Activity Using Nonnatural Molecules

  HAMACHI Itaru

  PacifiChem 2000, 14 Dec. 2000

  
• Control of Electron Transfer in Engineered Hemoproteins

  HAMACHI Itaru

  1st Biological Inorganic Chemistry Symposium, 17 Nov. 2000

  
• Molecular Recognition in Engineered Proteins

  HAMACHI Itaru

  2nd PEM(Peptide Engineering Meeting), 05 Sep. 2000, Invited

  
• Engineering Photoinduced Electron Transfer in Protein Matrix

  HAMACHI Itaru

  1st ICPP (International Conference on Porphyrin and Phthalocyamine), 25 Jun. 2000, Invited

  
• Manipulation of Structure & Activity of Native Enzymes by Organic Chemistry

  HAMACHI Itaru

  62nd Okazaki Conference, 08 Jan. 1999, Invited

  
• Chemical labeling of neurotransmitter receptors in live cell and brain

  Itaru Hamachi

  CMCB2022, 27 Jan. 2022

  
• Ligand-directed chemistry for endogenous protein modification

  Itaru Hamachi

  Pacifichem2021, 17 Dec. 2021, Invited

  
• 分子夾雑の化学で生命現象に挑む

  浜地 格

  第21回東北大学多元物質科学研究所研究発表会, 09 Dec. 2021, Invited

  
• 脳内有機化学の試み

  浜地 格

  学術変革領域(B)脳分子探査キックオフシンポジウム, 01 Dec. 2021, Invited

  
• 分⼦夾雑の⽣命化学が⽬指すもの

  浜地 格

  3新学術領域合同シンポジウム, 22 Nov. 2021

  
• 合成プローブで、生体系でのタンパク質機能を探る

  浜地 格

  第35回農薬デザイン研究会, 12 Nov. 2021, Invited

  
• 金属イオン応答性タンパク質ラベル化剤の開発とChemical biology

  浜地 格

  第32回日本微量元素学会学術集会, 15 Oct. 2021, Invited

  
• Design of stimuli-responsive short peptide fibers

  Itaru Hamachi

  EMBO Workshop: Designing functional biomolecular assemblies: Beyond biology, 30 Sep. 2021, Invited

  
• 細胞分子夾雑系の有機化学

  浜地 格

  第15回分子科学討論会, 18 Sep. 2021, Invited

  
• Bioorthogonal Protein labeling in live cells and beyond

  Itaru Hamachi

  RSC - IISER Desktop Seminar with ChemComm, 05 Aug. 2021, Invited

  
• Chemical labeling of biomolecules in live cells and beyond

  Itaru Hamachi

  Seminar at Numata Laboratory, RIKEN, 27 Jul. 2021, Invited

  
• 分子夾雑な生体系の化学を目指して

  浜地 格

  生体機能関連化学部会 若手の会 第32回 サマースクール, 16 Jul. 2021, Invited

  
• Ligand-Directed Labeling of Endogenous Proteins in Live Cells

  Itaru Hamachi

  RICT 2021-56th International Conference on Medicinal Chemistry, 07 Jul. 2021, Invited

  
• ケミカルラベルで細胞を覗く分子技術／Molecular technology relied on chemical labeling for unveiling cellular events

  浜地 格

  第73回日本細胞生物学会大会, 30 Jun. 2021, Invited