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Shirakawa, Masahiro

Graduate School of Engineering, Division of Molecular Engineering Professor

Shirakawa, Masahiro
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    Last Updated :2025/05/02

    Basic Information

    Faculty

    • Faculty of Engineering

    Concurrent Affiliation

    • Institute for Advanced Study, 物質－細胞統合システム拠点, 連携教授
    • Center for the Promotion of Interdisciplinary Education and Research (C-PiER), スーパーグローバルコース 化学系ユニット

    Academic Degree

    • 修士（理学）(大阪大学)
    • 博士（理学）(大阪大学)

    Language of Instruction

    • English

    ID,URL

    researchmap URL

    list
      Last Updated :2025/05/02

      Research

      Papers

      • Anomalous Formation of Irradiation-Induced Nitrogen-Vacancy Centers in 5 nm-Sized Detonation Nanodiamonds
        Frederick T. -K. So; Alexander I. Shames; Daiki Terada; Takuya Genjo; Hiroki Morishita; Izuru Ohki; Takeshi Ohshima; Shinobu Onoda; Hideaki Takashima; Shigeki Takeuchi; Norikazu Mizuochi; Ryuji Igarashi; Masahiro Shirakawa; Takuya F. Segawa
        JOURNAL OF PHYSICAL CHEMISTRY C, Mar. 2022, Peer-reviewed
      • Room-temperature hyperpolarization of polycrystalline samples with optically polarized triplet electrons: pentacene or nitrogen-vacancy center in diamond?
        Koichiro Miyanishi; Takuya F. Segawa; Kazuyuki Takeda; Izuru Ohki; Shinobu Onoda; Takeshi Ohshima; Hiroshi Abe; Hideaki Takashima; Shigeki Takeuchi; Alexander I. Shames; Kohki Morita; Yu Wang; Frederick T.-K. So; Daiki Terada; Ryuji Igarashi; Akinori Kagawa; Masahiro Kitagawa; Norikazu Mizuochi; Masahiro Shirakawa; Makoto Negoro
        Magnetic Resonance, 2021, Peer-reviewed
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      • Nanometre-Scale Visualization of Chemical Parameter Changes by T-1-Weighted ODMR Imaging Using a Fluorescent Nanodiamond
        Takahiro Fujisaku; Ryuji Igarashi; Masahiro Shirakawa
        CHEMOSENSORS, Sep. 2020, Peer-reviewed
      • Nanodiamond mediated interfacial polymerization for high performance nanofiltration membrane
        Detao Qin; Guoji Huang; Daiki Terada; Handong Jiang; Masateru M. Ito; Andrew H. Gibbons; Ryuji Igarashi; Daisuke Yamaguchi; Masahiro Shirakawa; Easan Sivaniah; Behnam Ghalei
        JOURNAL OF MEMBRANE SCIENCE, May 2020, Peer-reviewed
      • Tracking the 3D Rotational Dynamics in Nanoscopic Biological Systems
        Ryuji Igarashi; Takuma Sugi; Shingo Sotoma; Takuya Genjo; Yuta Kumiya; Erik Walinda; Hiroshi Ueno; Kazuhiro Ikeda; Hitoshi Sumiya; Hidehito Tochio; Yohsuke Yoshinari; Yoshie Harada; Masahiro Shirakawa
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Apr. 2020, Peer-reviewed
      • Nanodiamonds for bioapplications-specific targeting strategies
        Daiki Terada; Takuya Genjo; Takuya F. Segawa; Ryuji Igarashi; Masahiro Shirakawa
        BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, Feb. 2020, Peer-reviewed
      • pH Nanosensor Using Electronic Spins in Diamond
        Takahiro Fujisaku; Ryotaro Tanabe; Shinobu Onoda; Ryou Kubota; Takuya F. Segawa; Frederick T. -K. So; Takeshi Ohshima; Itaru Hamachi; Masahiro Shirakawa; Ryuji Igarashi
        ACS NANO, Oct. 2019, Peer-reviewed
      • Contribution of Coiled-Coil Assembly to Ca2+/Calmodulin-Dependent Inactivation of TRPC6 Channel and its Impacts on FSGS-Associated Phenotypes
        Onur K. Polat; Masatoshi Uno; Terukazu Maruyama; Ha Nam Tran; Kayo Imamura; Chee Fah Wong; Reiko Sakaguchi; Mariko Ariyoshi; Kyohei Itsuki; Jun Ichikawa; Takashi Morii; Masahiro Shirakawa; Ryuji Inoue; Katsuhiko Asanuma; Jochen Reiser; Hidehito Tochio; Yasuo Mori; Masayuki X. Mori
        JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, Sep. 2019, Peer-reviewed
      • A simple and soft chemical deaggregation method producing single-digit detonation nanodiamonds
        Daiki Terada; Frederick Tze Kit So; Bodo Hattendorf; Tamami Yanagi; Eiji Osawa; Norikazu Mizuochi; Masahiro Shirakawa; Ryuji Igarashi; Takuya Fabian Segawa
        NANOSCALE ADVANCES, May 2022, Peer-reviewed
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      • Overcoming humidity-induced swelling of graphene oxide-based hydrogen membranes using charge-compensating nanodiamonds
        Guoji Huang; Behnam Ghalei; Ali Pournaghshband Isfahani; H. Enis Karahan; Daiki Terada; Detao Qin; Conger Li; Masahiko Tsujimoto; Daisuke Yamaguchi; Kunihisa Sugimoto; Ryuji Igarashi; Bor Kae Chang; Tao Li; Masahiro Shirakawa; Easan Sivaniah
        NATURE ENERGY, Dec. 2021, Peer-reviewed
      • Non-contact measurement of internal body temperature using subcutaneously implanted diamond microparticles
        Kiichi Kaminaga; Hiromi Yanagihara; Takuya Genjo; Takamitsu Morioka; Hiroshi Abe; Masahiro Shirakawa; Takeshi Ohshima; Shizuko Kakinuma; Ryuji Igarashi
        BIOMATERIALS SCIENCE, Oct. 2021, Peer-reviewed
      • Label-free tomographic imaging of nanodiamonds in living cells
        Dini Kurnia Ikliptikawati; Masaharu Hazawa; Frederick T-K So; Daiki Terada; Akiko Kobayashi; Takuya F. Segawa; Masahiro Shirakawa; Richard W. Wong
        DIAMOND AND RELATED MATERIALS, Oct. 2021, Peer-reviewed
      • Fabrication of Detonation Nanodiamonds Containing Silicon-Vacancy Color Centers by High Temperature Annealing
        Konosuke Shimazaki; Hiroki Kawaguchi; Hideaki Takashima; Takuya Fabian Segawa; Frederick T. -K. So; Daiki Terada; Shinobu Onoda; Takeshi Ohshima; Masahiro Shirakawa; Shigeki Takeuchi
        PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE, Jul. 2021, Peer-reviewed
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      • 量子生命科学の将来展望
        馬場 嘉信; 白川 昌宏; 須原 哲也
        Optronics : 光技術コーディネートジャーナル, Aug. 2020
      • ユビキチン鎖の鎖長に依存した物性と分解 (特集 非定型型ユビキチン鎖の生理機能)
        森本 大智; 白川 昌宏
        生化学, Feb. 2020, Peer-reviewed
      • In-cell NMR Spectroscopy From Molecular Sciences to Cell Biology Preface
        Yutaka Ito; Volker Doetsch; Masahiro Shirakawa
        IN-CELL NMR SPECTROSCOPY: FROM MOLECULAR SCIENCES TO CELL BIOLOGY, 2020, Peer-reviewed
      • In-cell NMR in Eukaryotic Cells - I (Introduction from Outside of Cells)
        Kohsuke Inomata; Takanori Kigawa; Masahiro Shirakawa
        IN-CELL NMR SPECTROSCOPY: FROM MOLECULAR SCIENCES TO CELL BIOLOGY, 2020, Peer-reviewed
      • Monodisperse Five-Nanometer-Sized Detonation Nanodiamonds Enriched in Nitrogen-Vacancy Centers
        Daiki Terada; Takuya F. Segawa; Alexander I. Shames; Shinobu Onoda; Takeshi Ohshima; Eiji Osawa; Ryuji Igarashi; Masahiro Shirakawa
        ACS NANO, Jun. 2019, Peer-reviewed
      • High-Resolution Protein 3D Structure Determination in Living Eukaryotic Cells
        Takashi Tanaka; Teppei Ikeya; Hajime Kamoshida; Yusuke Suemoto; Masaki Mishima; Masahiro Shirakawa; Peter Guentert; Yutaka Ito
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, May 2019, Peer-reviewed
      • An innate interaction between IL-18 and the propeptide that inactivates its precursor form
        Naotaka Tsutsumi; Ayumi Yokota; Takeshi Kimura; Zenichiro Kato; Toshiyuki Fukao; Masahiro Shirakawa; Hidenori Ohnishi; Hidehito Tochio
        SCIENTIFIC REPORTS, Apr. 2019, Peer-reviewed
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      • Enrichment of ODMR-active nitrogen-vacancy centres in five-nanometre-sized detonation-synthesized nanodiamonds: Nanoprobes for temperature, angle and position
        Shingo Sotoma; Daiki Terada; Takuya F. Segawa; Ryuji Igarashi; Yoshie Harada; Masahiro Shirakawa
        Scientific Reports, 01 Dec. 2018, Peer-reviewed
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      • NMR resonance assignments of the NZF domain of mouse HOIL-1L free and bound to linear di-ubiquitin
        Naoki Ishii; Erik Walinda; Naoto Iwakawa; Daichi Morimoto; Kazuhiro Iwai; Kenji Sugase; Masahiro Shirakawa
        Biomolecular NMR Assignments, Dec. 2018, Peer-reviewed
      • Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88+
        Masatoshi Uno; Takahiro Watanabe-Nakayama; Hiroki Konno; Ken-ichi Akagi; Naotaka Tsutsumi; Toshiyuki Fukao; Masahiro Shirakawa; Hidenori Ohnishi; Hidehito Tochio
        CHEMICAL COMMUNICATIONS, Nov. 2018, Peer-reviewed
      • Backbone and side-chain resonance assignments of the methyl-CpG-binding domain of MBD6 from Arabidopsis thaliana
        Naoto Iwakawa; Yutaka Mahana; Arina Ono; Izuru Ohki; Erik Walinda; Daichi Morimoto; Kenji Sugase; Masahiro Shirakawa
        Biomolecular NMR Assignments, Sep. 2018, Peer-reviewed
      • One-Pot Synthesis of Highly Dispersible Fluorescent Nanodiamonds for Bioconjugation.
        Daiki Terada; Shingo Sotoma; Yoshie Harada; Ryuji Igarashi; Masahiro Shirakawa
        Bioconj. Chem.,, Aug. 2018, Peer-reviewed
      • Cooperative Domain Formation by Homologous Motifs in HOIL-1L and SHARPIN Plays A Crucial Role in LUBAC Stabilization
        Hiroaki Fujita; Akira Tokunaga; Satoshi Shimizu; Amanda L. Whiting; Francisco Aguilar-Alonso; Kenji Takagi; Erik Walinda; Yoshiteru Sasaki; Taketo Shimokawa; Tsunehiro Mizushima; Izuru Ohki; Mariko Ariyoshi; Hidehito Tochio; Federico Bernal; Masahiro Shirakawa; Kazuhiro Iwai
        Cell Reports, 24 Apr. 2018, Peer-reviewed
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      • Hydrogen-deuterium exchange profiles of polyubiquitin fibrils
        Daichi Morimoto; Ryo Nishizawa; Erik Walinda; Shingo Takashima; Kenji Sugase; Masahiro Shirakawa
        Polymers, 27 Feb. 2018, Peer-reviewed
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      • Isolation and characterization of a minimal building block of polyubiquitin fibrils
        Daichi Morimoto; Erik Walinda; Mayo Shinke; Kenji Sugase; Masahiro Shirakawa
        Scientific Reports, Feb. 2018, Peer-reviewed
      • Real-Time Observation of the Interaction between Thioflavin T and an Amyloid Protein by Using High-Sensitivity Rheo-NMR
        Naoto Iwakawa; Daichi Morimoto; Erik Walinda; Yasushi Kawata; Masahiro Shirakawa; Kenji Sugase
        INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Nov. 2017, Peer-reviewed
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      • Structureof the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance
        Satoshi Ishiyama; Atsuya Nishiyama; Yasushi Saeki; Kei Moritsugu; Daichi Morimoto; Luna Yamaguchi; Naoko Arai; Rumie Matsumura; Toru Kawakami; Yuichi Mishima; Hironobu Hojo; Shintaro Shimamura; Fuyuki Ishikawa; Shoji Tajima; Keiji Tanaka; Mariko Ariyoshi; Masahiro Shirakawa; Mitsunori Ikeguchi; Akinori Kidera; Isao Suetake; Kyohei Arita; Makoto Nakanishi
        MOLECULAR CELL, Oct. 2017, Peer-reviewed
      • RFTS-dependent negative regulation of Dnmt1 by nucleosome structure and histone tails
        Yuichi Mishima; Laura Brueckner; Saori Takahashi; Toru Kawakami; Kyohei Arita; Shota Oka; Junji Otani; Hironobu Hojo; Masahiro Shirakawa; Akira Shinohara; Mikio Watanabe; Isao Suetake
        FEBS JOURNAL, Oct. 2017, Peer-reviewed
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      • High-Sensitivity Rheo-NMR Spectroscopy for Protein Studies
        Daichi Morimoto; Erik Walinda; Naoto Iwakawa; Mayu Nishizawa; Yasushi Kawata; Akihiko Yamamoto; Masahiro Shirakawa; Ulrich Scheler; Kenji Sugase
        ANALYTICAL CHEMISTRY, Jul. 2017, Peer-reviewed
      • Biological and Physicochemical Functions of Ubiquitylation Revealed by Synthetic Chemistry Approaches
        Daichi Morimoto; Erik Walinda; Kenji Sugase; Masahiro Shirakawa
        INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Jun. 2017, Peer-reviewed
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      • Hexaphyrin as a Potential Theranostic Dye for Photothermal Therapy and F-19 Magnetic Resonance Imaging
        Tomohiro Higashino; Hirotaka Nakatsuji; Ryosuke Fukuda; Haruki Okamoto; Hirohiko Imai; Tetsuya Matsuda; Hidehito Tochio; Masahiro Shirakawa; Nikolai V. Tkachenko; Mitsuru Hashida; Tatsuya Murakami; Hiroshi Imahori
        CHEMBIOCHEM, May 2017, Peer-reviewed
      • F (1) F (2)-selective NMR spectroscopy
        Erik Walinda; Daichi Morimoto; Masahiro Shirakawa; Kenji Sugase
        JOURNAL OF BIOMOLECULAR NMR, May 2017, Peer-reviewed
      • Backbone resonance assignments of monomeric SOD1 in dilute and crowded environments
        Naoto Iwakawa; Daichi Morimoto; Erik Walinda; Kenji Sugase; Masahiro Shirakawa
        BIOMOLECULAR NMR ASSIGNMENTS, Apr. 2017, Peer-reviewed
      • Practical considerations for investigation of protein conformational dynamics by N-15 R (1 rho) relaxation dispersion
        Erik Walinda; Daichi Morimoto; Masahiro Shirakawa; Kenji Sugase
        JOURNAL OF BIOMOLECULAR NMR, Mar. 2017, Peer-reviewed
      • Ubiquitylation Directly Induces Fold Destabilization of Proteins
        Daichi Morimoto; Erik Walinda; Harumi Fukada; Kenji Sugase; Masahiro Shirakawa
        SCIENTIFIC REPORTS, Dec. 2016, Peer-reviewed
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      • A Nanodiamond-peptide Bioconjugate for Fluorescence and ODMR Microscopy of a Single Actin Filament
        Takuya Genjo; Shingo Sotoma; Ryotaro Tanabe; Ryuji Igarasm; Masahiro Shirakawa
        ANALYTICAL SCIENCES, Nov. 2016, Peer-reviewed
      • A new carbamidemethyl-linked lanthanoid chelating tag for PCS NMR spectroscopy of proteins in living HeLa cells
        Yuya Hikone; Go Hirai; Masaki Mishima; Kohsuke Inomata; Teppei Ikeya; Souichiro Arai; Masahiro Shirakawa; Mikiko Sodeoka; Yutaka Ito
        JOURNAL OF BIOMOLECULAR NMR, Oct. 2016, Peer-reviewed
      • Efficient identification and analysis of chemical exchange in biomolecules by R-1 rho relaxation dispersion with Amaterasu
        Erik Walinda; Daichi Morimoto; Mayu Nishizawa; Masahiro Shirakawa; Kenji Sugase
        BIOINFORMATICS, Aug. 2016, Peer-reviewed
      • Dual Function of Phosphoubiquitin in E3 Activation of Parkin
        Erik Walinda; Daichi Morimoto; Kenji Sugase; Masahiro Shirakawa
        JOURNAL OF BIOLOGICAL CHEMISTRY, Aug. 2016, Peer-reviewed
      • Monodispersed Colloidal Solutions of Surface-modified Detonation-synthesized Nanodiamonds and Their Aggregation Resistance
        Shingo Sotoma; Masahiro Shirakawa
        CHEMISTRY LETTERS, Jun. 2016, Peer-reviewed
      • The evolving world of ubiquitin: Transformed polyubiquitin chains
        Daichi Morimoto; Masahiro Shirakawa
        Biomolecular Concepts, 01 Jun. 2016, Peer-reviewed
      • Moderate plasma treatment enhances the quality of optically detected magnetic resonance signals of nitrogen-vacancy centres in nanodiamonds
        Shingo Sotoma; Ryuji Igarashi; Masahiro Shirakawa
        APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING, May 2016, Peer-reviewed
      • Selective Labeling of Proteins on Living Cell Membranes Using Fluorescent Nanodiamond Probes
        Shingo Sotoma; Jun Iimura; Ryuji Igarashi; Koichiro M. Hirosawa; Hidenori Ohnishi; Shin Mizukami; Kazuya Kikuchi; Takahiro K. Fujiwara; Masahiro Shirakawa; Hidehito Tochio
        NANOMATERIALS, Apr. 2016, Peer-reviewed
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      • ナノダイヤモンドNVCを使った新しい生体・細胞計測法 (特集 新しい光学技術 : 生体とダイヤモンドにフォーカス)
        五十嵐 龍治; 杤尾 豪人; 白川 昌宏
        光技術コンタクト = Optical and electro-optical engineering contact, Jan. 2016
      • Nucleosome compaction facilitates HP1 gamma binding to methylated H3K9
        Yuichi Mishima; Chanika D. Jayasinghe; Kai Lu; Junji Otani; Masahiro Shirakawa; Toru Kawakami; Hironobu Kimura; Hironobu Hojo; Peter Carlton; Shoji Tajima; Isao Suetake
        NUCLEIC ACIDS RESEARCH, Dec. 2015, Peer-reviewed
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      • Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation
        Megumi Tsuchiya; Shin Isogai; Hiroaki Taniguchi; Hidehito Tochio; Masahiro Shirakawa; Ken-ichirou Morohashi; Yasushi Hiraoka; Tokuko Haraguchi; Hidesato Ogawa
        SCIENTIFIC REPORTS, Sep. 2015, Peer-reviewed
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      • Suppression of Nonspecific Protein-Nanodiamond Adsorption Enabling Specific Targeting of Nanodiamonds to Biomolecules of Interest
        Shingo Sotoma; Ryuji Igarashi; Jun Iimura; Yuta Kumiya; Hidehito Tochio; Yoshie Harada; Masahiro Shirakawa
        CHEMISTRY LETTERS, Mar. 2015, Peer-reviewed
      • Optically Detected Magnetic Resonance of Nanodiamonds In Vivo; Implementation of Selective Imaging and Fast Sampling
        Yosuke Yoshinari; Shigeyuki Mori; Ryuji Igarashi; Takuma Sugi; Hiroaki Yokota; Kazuhiro Ikeda; Hitoshi Sumiya; Ikue Mori; Hidehito Tochio; Yoshie Harada; Masahiro Shirakawa
        JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, Feb. 2015, Peer-reviewed
      • The unexpected role of polyubiquitin chains in the formation of fibrillar aggregates
        Daichi Morimoto; Erik Walinda; Harumi Fukada; Yu-Shin Sou; Shun Kageyama; Masaru Hoshino; Takashi Fujii; Hikaru Tsuchiya; Yasushi Saeki; Kyohei Arita; Mariko Ariyoshi; Hidehito Tochio; Kazuhiro Iwai; Keiichi Namba; Masaaki Komatsu; Keiji Tanaka; Masahiro Shirakawa
        Nature Communications, Jan. 2015, Peer-reviewed
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      • Magnetic Resonance Imaging of Tumor with a Self-Traceable Phosphorylcholine Polymer
        Hisatsugu Yamada; Yoshinori Hasegawa; Hirohiko Imai; Yuki Takayama; Fuminori Sugihara; Tetsuya Matsuda; Hidehito Tochio; Masahiro Shirakawa; Shinsuke Sando; Yu Kimura; Akio Toshimitsu; Yasuhiro Aoyama; Teruyuki Kondo
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jan. 2015, Peer-reviewed
      • Comprehensive and quantitative analysis for controlling the physical/chemical states and particle properties of nanodiamonds for biological applications
        S. Sotoma; K. Akagi; S. Hosokawa; R. Igarashi; H. Tochio; Y. Harada; M. Shirakawa
        RSC ADVANCES, 2015, Peer-reviewed
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      • High-throughput optical quantification of mechanosensory habituation reveals neurons encoding memory in Caenorhabditis elegans
        Takuma Sugi; Yasuko Ohtani; Yuta Kumiya; Ryuji Igarashi; Masahiro Shirakawa
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Dec. 2014, Peer-reviewed
      • The structural basis for receptor recognition of human interleukin-18
        Naotaka Tsutsumi; Takeshi Kimura; Kyohei Arita; Mariko Ariyoshi; Hidenori Ohnishi; Takahiro Yamamoto; Xiaobing Zuo; Katsumi Maenaka; Enoch Y. Park; Naomi Kondo; Masahiro Shirakawa; Hidehito Tochio; Zenichiro Kato
        NATURE COMMUNICATIONS, Dec. 2014, Peer-reviewed
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      • Purification, crystallization and preliminary X-ray crystallographic analysis of human IL-18 and its extracellular complexes
        Takeshi Kimura; Naotaka Tsutsumi; Kyohei Arita; Mariko Ariyoshi; Hidenori Ohnishi; Naomi Kondo; Masahiro Shirakawa; Zenichiro Kato; Hidehito Tochio
        ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS, Oct. 2014, Peer-reviewed
      • Effective production of fluorescent nanodiamonds containing negatively-charged nitrogen-vacancy centers by ion irradiation
        Shingo Sotoma; Yohsuke Yoshinari; Ryuji Igarashi; Akiyoshi Yamazaki; Shige H. Yoshimura; Hidehito Tochio; Masahiro Shirakawa; Yoshie Harada
        DIAMOND AND RELATED MATERIALS, Oct. 2014, Peer-reviewed
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      • Ubiquitin-proteasome-mediated degradation of S-RNase in a solanaceous cross-compatibility reaction
        Tetsuyuki Entani; Ken-ichi Kubo; Shin Isogai; Yoichiro Fukao; Masahiro Shirakawa; Akira Isogai; Seiji Takayama
        PLANT JOURNAL, Jun. 2014, Peer-reviewed
      • Solution Structure of the Ubiquitin-associated ( UBA) Domain of Human Autophagy Receptor NBR1 and Its Interaction with Ubiquitin and Polyubiquitin
        Erik Walinda; Daichi Morimoto; Kenji Sugase; Tsuyoshi Konuma; Hidehito Tochio; Masahiro Shirakawa
        JOURNAL OF BIOLOGICAL CHEMISTRY, May 2014, Peer-reviewed
      • Functional assessment of the mutational effects of human IRAK4 and MyD88 genes
        Takahiro Yamamoto; Naotaka Tsutsumi; Hidehito Tochio; Hidenori Ohnishi; Kazuo Kubota; Zenichiro Kato; Masahiro Shirakawa; Naomi Kondo
        MOLECULAR IMMUNOLOGY, Mar. 2014, Peer-reviewed
      • The DNA Methyltransferase Dnmt1 Directly Interacts with the SET and RING Finger-associated (SRA) Domain of the Multifunctional Protein Uhrf1 to Facilitate Accession of the Catalytic Center to Hemi-methylated DNA
        Ahmet Can Berkyurek; Isao Suetake; Kyohei Arita; Kohei Takeshita; Atsushi Nakagawa; Masahiro Shirakawa; Shoji Tajima
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2014, Peer-reviewed
      • Optically Detected Magnetic Resonance of Nitrogen-Vacancy Centers in a Diamond
        五十嵐 龍治; 白川 昌宏
        細胞工学, Jan. 2014
      • Cell Cycle-Dependent Turnover of 5-Hydroxymethyl Cytosine in Mouse Embryonic Stem Cells
        Junji Otani; Hironobu Kimura; Jafar Sharif; Takaho A. Endo; Yuichi Mishima; Toru Kawakami; Haruhiko Koseki; Masahiro Shirakawa; Isao Suetake; Shoji Tajima
        PLOS ONE, Dec. 2013, Peer-reviewed
      • An in-cell NMR study of monitoring stress-induced increase of cytosolic Ca2+ concentration in HeLa cells
        Dambarudhar Shiba Sankar Hembram; Takahiro Haremaki; Jumpei Hamatsu; Jin Inoue; Hajime Kamoshida; Teppei Ikeya; Masaki Mishima; Tsutomu Mikawa; Nobuhiro Hayashi; Masahiro Shirakawa; Yutaka Ito
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Sep. 2013, Peer-reviewed
      • Development of fluorogenic probes for quick No-Wash live-cell imaging of intracellular proteins
        Yuichiro Hori; Tomoya Norinobu; Motoki Sato; Kyohei Arita; Masahiro Shirakawa; Kazuya Kikuchi
        Journal of the American Chemical Society, 21 Aug. 2013, Peer-reviewed
      • Pruning the ALS-Associated Protein SOD1 for in-Cell NMR
        Jens Danielsson; Kohsuke Inomata; Shuhei Murayama; Hidehito Tochio; Lisa Lang; Masahiro Shirakawa; Mikael Oliveberg
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jul. 2013, Peer-reviewed
      • MIT domain of Vps4 is a Ca2+-dependent phosphoinositide-binding domain
        Naoko Iwaya; Hirotoshi Takasu; Natsuko Goda; Masahiro Shirakawa; Toshiki Tanaka; Daizo Hamada; Hidekazu Hiroaki
        JOURNAL OF BIOCHEMISTRY, May 2013, Peer-reviewed
      • Structural Basis of the Versatile DNA Recognition Ability of the Methyl-CpG Binding Domain of Methyl-CpG Binding Domain Protein 4
        Junji Otani; Kyohei Arita; Tsuyoshi Kato; Mariko Kinoshita; Hironobu Kimura; Isao Suetake; Shoji Tajima; Mariko Ariyoshi; Masahiro Shirakawa
        JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2013, Peer-reviewed
      • Lysyl 5-Hydroxylation, a Novel Histone Modification, by Jumonji Domain Containing 6 (JMJD6)
        Motoko Unoki; Akiko Masuda; Naoshi Dohmae; Kyohei Arita; Masanori Yoshimatsu; Yukiko Iwai; Yoshinori Fukui; Koji Ueda; Ryuji Hamamoto; Masahiro Shirakawa; Hiroyuki Sasaki; Yusuke Nakamura
        JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2013, Peer-reviewed
      • High-Resolution Heteronuclear Multidimensional NMR of Proteins in Living Insect Cells Using a Baculovirus Protein Expression System
        Jumpei Hamatsu; Daniel O'Donovan; Takashi Tanaka; Takahiro Shirai; Yuichiro Hourai; Tsutomu Mikawa; Teppei Ikeya; Masaki Mishima; Wayne Boucher; Brian O. Smith; Ernest D. Laue; Masahiro Shirakawa; Yutaka Ito
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Feb. 2013, Peer-reviewed
      • Hinge and Chromoshadow of HP1 alpha Participate in Recognition of K9 Methylated Histone H3 in Nucleosomes
        Yuichi Mishima; Makoto Watanabe; Toru Kawakami; Chanika D. Jayasinghe; Junji Otani; Yusuke Kikugawa; Masahiro Shirakawa; Hiroshi Kimura; Osamu Nishimura; Saburo Aimoto; Shoji Tajima; Isao Suetake
        JOURNAL OF MOLECULAR BIOLOGY, Jan. 2013, Peer-reviewed
      • Utilization of lysine C-13-methylation NMR for protein-protein interaction studies
        Yoshikazu Hattori; Kyoko Furuita; Izuru Ohki; Takahisa Ikegami; Harumi Fukada; Masahiro Shirakawa; Toshimichi Fujiwara; Chojiro Kojima
        JOURNAL OF BIOMOLECULAR NMR, Jan. 2013, Peer-reviewed
      • A Structured Monodisperse PEG for the Effective Suppression of Protein Aggregation
        Takahiro Muraoka; Kota Adachi; Mihoko Ui; Shunichi Kawasaki; Nabanita Sadhukhan; Haruki Obara; Hidehito Tochio; Masahiro Shirakawa; Kazushi Kinbara
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2013, Peer-reviewed
      • Quantitative comparison of protein dynamics in live cells and in vitro by in-cell F-19-NMR
        Yousuke Takaoka; Yoshiyuki Kioi; Akira Morito; Junji Otani; Kyohei Arita; Eishi Ashihara; Mariko Ariyoshi; Hidehito Tochio; Masahiro Shirakawa; Itaru Hamachi
        CHEMICAL COMMUNICATIONS, 2013, Peer-reviewed
      • Real-Time Background-Free Selective Imaging of Fluorescent Nanodiamonds in Vivo
        Ryuji Igarashi; Yohsuke Yoshinari; Hiroaki Yokota; Takuma Sugi; Fuminori Sugihara; Kazuhiro Ikeda; Hitoshi Sumiya; Shigenori Tsuji; Ikue Mori; Hidehito Tochio; Yoshie Harada; Masahiro Shirakawa
        NANO LETTERS, Nov. 2012, Peer-reviewed
      • Molecular analysis of the binding mode of Toll/interleukin-1 receptor (TIR) domain proteins during TLR2 signaling
        Masatoshi Nada; Hidenori Ohnishi; Hidehito Tochio; Zenichiro Kato; Takeshi Kimura; Kazuo Kubota; Takahiro Yamamoto; Yuji O. Kamatari; Naotaka Tsutsumi; Masahiro Shirakawa; Naomi Kondo
        MOLECULAR IMMUNOLOGY, Oct. 2012, Peer-reviewed
      • Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1
        Kyohei Arita; Shin Isogai; Takashi Oda; Motoko Unoki; Kazuya Sugita; Naotaka Sekiyama; Keiko Kuwata; Ryuji Hamamoto; Hidehito Tochio; Mamoru Sato; Mariko Ariyoshi; Masahiro Shirakawa
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2012, Peer-reviewed
      • Effect of Ca2+on the microtubule-severing enzyme p60-katanin. Insight into the substrate-dependent activation mechanism
        Naoko Iwaya; Kohei Akiyama; Natsuko Goda; Takeshi Tenno; Yoshie Fujiwara; Daizo Hamada; Teikichi Ikura; Masahiro Shirakawa; Hidekazu Hiroaki
        FEBS JOURNAL, Apr. 2012, Peer-reviewed
      • NMR analysis of Lys63-linked polyubiquitin recognition by the tandem ubiquitin-interacting motifs of Rap80
        Naotaka Sekiyama; JunGoo Jee; Shin Isogai; Ken-ichi Akagi; Tai-huang Huang; Mariko Ariyoshi; Hidehito Tochio; Masahiro Shirakawa
        JOURNAL OF BIOMOLECULAR NMR, Apr. 2012, Peer-reviewed
      • Substrate/Product-Targeted NMR Monitoring of Pyrimidine Catabolism and Its Inhibition by a Clinical Drug
        Hisatsugu Yamada; Keigo Mizusawa; Ryuji Igarashi; Hidehito Tochio; Masahiro Shirakawa; Yasuhiko Tabata; Yu Kimura; Teruyuki Kondo; Yasuhiro Aoyama; Shinsuke Sando
        ACS CHEMICAL BIOLOGY, Mar. 2012, Peer-reviewed
      • Structural Analysis of Proteins in Living Eukaryotic Cells Using Magnetic Resonance Spectroscopy
        Hidehito Tochio; Masahiro Shirakawa
        YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Feb. 2012, Peer-reviewed
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      • 磁気共鳴を使った真核細胞内タンパク質の構造・機能解析
        杤尾 豪人; 白川 昌宏
        薬学雑誌, Jan. 2012, Peer-reviewed
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      • Crystal Structure of the Ubiquitin-associated (UBA) Domain of p62 and Its Interaction with Ubiquitin
        Shin Isogai; Daichi Morimoto; Kyohei Arita; Satoru Unzai; Takeshi Tenno; Jun Hasegawa; Yu-shin Sou; Masaaki Komatsu; Keiji Tanaka; Masahiro Shirakawa; Hidehito Tochio
        JOURNAL OF BIOLOGICAL CHEMISTRY, Sep. 2011, Peer-reviewed
      • Structure and Function of the N-terminal Nucleolin Binding Domain of Nuclear Valosin-containing Protein-like 2 (NVL2) Harboring a Nucleolar Localization Signal
        Yoshie Fujiwara; Ken-ichiro Fujiwara; Natsuko Goda; Naoko Iwaya; Takeshi Tenno; Masahiro Shirakawa; Hidekazu Hiroaki
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2011, Peer-reviewed
      • Structural difference of vasoactive intestinal peptide in two distinct membrane-mimicking environments
        Yoshitaka Umetsu; Takeshi Tenno; Natsuko Goda; Masahiro Shirakawa; Takahisa Ikegami; Hidekazu Hiroaki
        BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, May 2011, Peer-reviewed
      • In-Cell NMR Spectroscopy in Protein Chemistry and Drug Discovery
        Ayako Ohno; Kohsuke Inomata; Hidehito Tochio; Masahiro Shirakawa
        CURRENT TOPICS IN MEDICINAL CHEMISTRY, Jan. 2011, Peer-reviewed
      • 1SH-04 Magnetic resonance methods for analyses of structure and dynamics of intracellular proteins and cells(1SH Visualizing proteins in action -frontiers in biomolecular imaging-,The 49th Annual Meeting of the Biophysical Society of Japan)
        Shirakawa Masahiro
        Seibutsu Butsuri, Jan. 2011, Peer-reviewed
      • Structural Basis for Recognition of Methylated DNA in Epigenetic Regulation
        ARIYOSHI Mariko; SHIRAKAWA Masahiro
        Seibutsu Butsuri, Jan. 2011, Peer-reviewed
      • F-19 MRI detection of beta-galactosidase activity for imaging of gene expression
        Shin Mizukami; Hisashi Matsushita; Rika Takikawa; Fuminori Sugihara; Masahiro Shirakawa; Kazuya Kikuchi
        CHEMICAL SCIENCE, 2011, Peer-reviewed
      • H-1, C-13, and N-15 resonance assignment of the TIR domain of human MyD88
        Hidenori Ohnishi; Hidehito Tochio; Zenichiro Kato; Takeshi Kimura; Hidekazu Hiroaki; Naomi Kondo; Masahiro Shirakawa
        BIOMOLECULAR NMR ASSIGNMENTS, Oct. 2010, Peer-reviewed
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      • Turn-on Detection of Targeted Biochemical Reactions by Triple Resonance NMR Analysis Using Isotope-labeled Probe
        Keigo Mizusawa; Ryuji Igarashi; Kosei Uehira; Yoshimasa Takafuji; Yasuhiko Tabata; Hidehito Tochio; Masahiro Shirakawa; Shinsuke Sando; Yasuhiro Aoyama
        CHEMISTRY LETTERS, Sep. 2010, Peer-reviewed
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      • 2SC1422 Structure and folding stability of proteins in cells(2SC Advanced Insight into Protein Motions-in silico, in vitro and in vivo Studies,The 48th Annual Meeting of the Biophysical Society of Japan)
        Shirakawa Masahiro
        Seibutsu Butsuri, Aug. 2010
      • Purification, crystallization and preliminary crystallographic studies of Lys48-linked polyubiquitin chains
        Daichi Morimoto; Shin Isogai; Takeshi Tenno; Hidehito Tochio; Masahiro Shirakawa; Mariko Ariyoshi
        ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Jun. 2010, Peer-reviewed
      • Distance Determination in Proteins inside
        Ryuji Igarashi; Tomomi Sakai; Hideyuki Hara; Takeshi Tenno; Toshiaki Tanaka; Hidehito Tochio; Masahiro Shirakawa
        Journal of the American Chemical Society, Jun. 2010, Peer-reviewed
      • Structure and mutagenesis studies of the C-terminal region of licensing factor Cdt1 enable the identification of key residues for binding to replicative helicase Mcm proteins.
        Jungoo Jee; Takeshi Mizuno; Katsuhiko Kamada; Hidehito Tochio; Yasumasa Chiba; Ken-Ichiro Yanagi; Gentaro Yasuda; Hidekazu Hiroaki; Fumio Hanaoka; Masahiro Shirakawa
        The Journal of biological chemistry, 21 May 2010, Peer-reviewed
      • Structural basis for regulation of poly-SUMO chain by a SUMO-like domain of Nip45
        Naotaka Sekiyama; Kyohei Arita; Yoshihiro Ikeda; Kohtaro Hashiguchi; Mariko Ariyoshi; Hidehito Tochio; Hisato Saitoh; Masahiro Shirakawa
        PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, May 2010, Peer-reviewed
      • A Common Substrate Recognition Mode Conserved between Katanin p60 and VPS4 Governs Microtubule Severing and Membrane Skeleton Reorganization
        Naoko Iwaya; Yohta Kuwahara; Yoshie Fujiwara; Natsuko Goda; Takeshi Tenno; Kohei Akiyama; Shogo Mase; Hidehito Tochio; Takahisa Ikegami; Masahiro Shirakawa; Hidekazu Hiroaki
        JOURNAL OF BIOLOGICAL CHEMISTRY, May 2010, Peer-reviewed
      • Solution structure of a zinc-finger domain that binds to poly-ADP-ribose
        Shin Isogai; Shin-Ichiro Kanno; Mariko Ariyoshi; Hidehito Tochio; Yutaka Ito; Akira Yasui; Masahiro Shirakawa
        GENES TO CELLS, Feb. 2010, Peer-reviewed
      • NMR protein structure determination in living E. coli cells using nonlinear sampling
        Teppei Ikeya; Atsuko Sasaki; Daisuke Sakakibara; Yoshiki Shigemitsu; Junpei Hamatsu; Tomomi Hanashima; Masaki Mishima; Masatoshi Yoshimasu; Nobuhiro Hayashi; Tsutomu Mikawa; Daniel Nietlispach; Markus Waelchli; Brian O. Smith; Masahiro Shirakawa; Peter Guentert; Yutaka Ito
        NATURE PROTOCOLS, 2010, Peer-reviewed
      • Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX-DNMT3-DNMT3L domain
        Junji Otani; Toshiyuki Nankumo; Kyohei Arita; Susumu Inamoto; Mariko Ariyoshi; Masahiro Shirakawa
        EMBO REPORTS, Nov. 2009, Peer-reviewed
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      • Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling
        Hidenori Ohnishi; Hidehito Tochio; Zenichiro Kato; Kenji E. Orii; Ailian Li; Takeshi Kimura; Hidekazu Hiroaki; Naomi Kondo; Masahiro Shirakawa
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jun. 2009, Peer-reviewed
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      • High-resolution multi-dimensional NMR spectroscopy of proteins in human cells
        Kohsuke Inomata; Ayako Ohno; Hidehito Tochio; Shin Isogai; Takeshi Tenno; Ikuhiko Nakase; Toshihide Takeuchi; Shiroh Futaki; Yutaka Ito; Hidekazu Hiroaki; Masahiro Shirakawa
        NATURE, Mar. 2009, Peer-reviewed
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      • Protein structure determination in living cells by in-cell NMR spectroscopy
        Daisuke Sakakibara; Atsuko Sasaki; Teppei Ikeya; Junpei Hamatsu; Tomomi Hanashima; Masaki Mishima; Masatoshi Yoshimasu; Nobuhiro Hayashi; Tsutomu Mikawa; Markus Waelchli; Brian O. Smith; Masahiro Shirakawa; Peter Guentert; Yutaka Ito
        NATURE, Mar. 2009, Peer-reviewed
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      • Molecular Basis for SUMOylation-dependent Regulation of DNA Binding Activity of Heat Shock Factor 2
        Yukihiro Tateishi; Mariko Ariyoshi; Ryuji Igarashi; Hideyuki Hara; Kenji Mizuguchi; Azusa Seto; Akira Nakai; Tetsuro Kokubo; Hidehito Tochio; Masahiro Shirakawa
        JOURNAL OF BIOLOGICAL CHEMISTRY, Jan. 2009, Peer-reviewed
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      • Self-assembling nanoprobes that display off/on 19F nuclear magnetic resonance signals for protein detection and imaging
        Takaoka, Yousuke; Sakamoto, Takashi; Tsukiji, Shinya; Narazaki, Michiko; Matsuda, Tetsuya; Tochio, Hidehito; Shirakawa, Masahiro; Hamachi, Itaru
        Nature chemistry, 2009, Peer-reviewed
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      • Dual-Function Probe to Detect Protease Activity for Fluorescence Measurement and F-19 MRI
        Shin Mizukami; Rika Takikawa; Fuminori Sugihara; Masahiro Shirakawa; Kazuya Kikuchi
        ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, Peer-reviewed
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      • Structure of the small ubiquitin-like modifier (SUMO)-interacting motif of MBD1-containing chromatin-associated factor 1 bound to SUMO-3.
        Naotaka Sekiyama; Takahisa Ikegami; Tsutomu Yamane; Mitsunori Ikeguchi; Yasuhiro Uchimura; Daichi Baba; Mariko Ariyoshi; Hidehito Tochio; Hisato Saitoh; Masahiro Shirakawa
        The Journal of biological chemistry, 19 Dec. 2008, Peer-reviewed
      • The solution structure of the C-terminal domain of NfeD reveals a novel membrane-anchored OB-fold
        Yohta Kuwahara; Ayako Ohno; Taichi Morii; Hideshi Yokoyama; Ikuo Matsui; Hidehito Tochio; Masahiro Shirakawa; Hidekazu Hiroaki
        PROTEIN SCIENCE, Nov. 2008, Peer-reviewed
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      • Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism
        Kyohei Arita; Mariko Ariyoshi; Hidehito Tochio; Yusuke Nakamura; Masahiro Shirakawa
        NATURE, Oct. 2008, Peer-reviewed
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      • Intracellular protein delivery activity of peptides derived from insulin-like growth factor binding proteins 3 and 5
        Natsuko Goda; Takeshi Tenno; Kosuke Inomata; Masahiro Shirakawa; Toshiki Tanaka; Hidekazu Hiroaki
        EXPERIMENTAL CELL RESEARCH, Aug. 2008, Peer-reviewed
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      • Kinetic and thermodynamic evidence for flipping of a methyl-CpG binding domain on methylated DNA
        Kosuke Inomata; Izuru Ohki; Hidehito Tochio; Kenichiro Fujiwara; Hidekazu Hiroaki; Masahiro Shirakawat
        BIOCHEMISTRY, Mar. 2008, Peer-reviewed
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      • Paramagnetic relaxation-based F-19 MRI probe to detect protease activity
        Shin Mizukami; Rika Takikawa; Fuminori Sugihara; Yuichiro Hori; Hidehito Tochio; Markus Walchli; Masahiro Shirakawa; Kazuya Kikuchi
        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, Jan. 2008
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      • Paramagnetic relaxation-based F-19 MRI probe to detect protease activity
        Rika Takikawa; Shin Mizukami; Fuminori Sugihara; Masahiro Shirakawa; Kazuya Kikuchi
        YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2008, Peer-reviewed
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      • Protein modification by SUMO
        Shin Isogai; Masahiro Shirakawa
        SEIKAGAKU, Dec. 2007
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      • Structural analysis of pituitary adenylate cyclase-activating polypeptides bound to phospholipid membranes by magic angle spinning solid-state NMR
        Nobuyasu Komi; Kayo Okawa; Yukihiro Tateishi; Masahiro Shirakawa; Toshimichi Fujiwara; Hideo Akutsu
        BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Dec. 2007, Peer-reviewed
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      • Distance determination in human ubiquitin by pulsed double electron-electron resonance and double quantum coherence ESR methods
        H. Hara; T. Tenno; M. Shirakawa
        JOURNAL OF MAGNETIC RESONANCE, Jan. 2007
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      • Fine-tuning of protein domain boundary by minimizing potential coiled coil regions
        Naoko Iwaya; Natsuko Goda; Satoru Unzai; Kenichiro Fujiwara; Toshiki Tanaka; Kentaro Tomii; Hidehito Tochio; Masahiro Shirakawa; Hidekazu Hiroaki
        JOURNAL OF BIOMOLECULAR NMR, Jan. 2007
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      • Crystallization and preliminary X-ray analysis of human MTH1 complexed with two oxidized nucleotides, 8-oxo-dGMP and 2-oxo-dATP
        Teruya Nakamura; Yuki Kitaguchi; Masayuki Miyazawa; Hiroyuki Kamiya; Sachiko Toma; Shinji Ikemizu; Masahiro Shirakawa; Yusaku Nakabeppu; Yuriko Yamagata
        ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS, Dec. 2006
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      • In-cell NMR spectroscopy of proteins inside Xenopus laevis oocytes
        Tomomi Sakai; Hidehito Tochio; Takeshi Tenno; Yutaka Ito; Tetsuro Kokubo; Hidekazu Hiroaki; Masahiro Shirakawa
        JOURNAL OF BIOMOLECULAR NMR, Nov. 2006
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      • The common phospholipid-binding activity of the N-terminal domains of PEX1 and VCP/p97
        Kumiko Shiozawa; Natsuko Goda; Toshiyuki Shimizu; Kenji Mizuguchi; Naomi Kondo; Nobuyuki Shimozawa; Masahiro Shirakawa; Hidekazu Hiroaki
        FEBS JOURNAL, Nov. 2006
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      • Crystal structure of SUMO-3-modified thymine-DNA glycosylase
        D Baba; N Maita; JG Jee; Y Uchimura; H Saitoh; K Sugasawa; F Hanaoka; H Tochio; H Hiroaki; M Shirakawa
        JOURNAL OF MOLECULAR BIOLOGY, May 2006
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      • The structure of the third intracellular loop of the muscarinic acetylcholine receptor M-2 subtype
        S Ichlyama; Y Oka; K Haga; S Kojima; Y Tateishi; M Shirakawa; T Haga
        FEBS LETTERS, Jan. 2006
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      • A novel magnetic resonance-based method to measure gene expression in living cells
        S Ki; F Sugihara; K Kasahara; H Tochio; A Okada-Marubayashi; S Tomita; M Morita; M Ikeguchi; M Shirakawa; T Kokubo
        NUCLEIC ACIDS RESEARCH, 2006
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      • Structural characterization of the MIT domain from human Vps4b
        H Takasu; JG Jee; A Ohno; N Goda; K Fujiwara; H Tochio; M Shirakawa; H Hiroaki
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Aug. 2005
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      • Crystal structure of thymine DNA glycosylase conjugated to SUMO-1
        D Baba; N Maita; JG Jee; Y Uchimura; H Saitoh; K Sugasawa; F Hanaoka; H Tochio; H Hiroaki; M Shirakawa
        NATURE, Jun. 2005
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      Misc.

      • Recognition of modification status on a histone H3 tail by linked histone reader modules of the epigenetic regulator UHRF1
        Kyohei Arita; Shin Isogai; Takashi Oda; Motoko Unoki; Kazuya Sugita; Naotaka Sekiyama; Keiko Kuwata; Ryuji Hamamoto; Hidehito Tochio; Mamoru Sato; Mariko Ariyoshi; Masahiro Shirakawa
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2012, Peer-reviewed
      • “多重共鳴NMR を応用した生体内代謝プロセスの直接追跡と薬剤活性のその場評価”
        山田久嗣; 水澤圭吾; 五十嵐龍二; 杤尾豪人; 白川昌宏; 田畑泰彦; 木村祐; 近藤輝幸; 青山安宏; 山東信介
        第5回バイオ関連化学シンポジウム,2011.9.26, 2011, Peer-reviewed
      • “多重共鳴NMR 法を用いた生体内代謝プロセスの直接追跡”
        山田久嗣; 水澤圭吾; 五十嵐龍二; 枋尾豪人; 白川昌宏; 田畑泰彦; 木村祐; 近藤輝幸; 山東信介; 青山安宏
        第6回日本分子イメージング学会学術集会,2011.5.26, 2011, Peer-reviewed
      • Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling
        Hidenori Ohnishi; Hidehito Tochio; Zenichiro Kato; Kenji E. Orii; Ailian Li; Takeshi Kimura; Hidekazu Hiroaki; Naomi Kondo; Masahiro Shirakawa
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jun. 2009, Peer-reviewed
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      • Methylated DNA-binding domain 1 and methyipurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin
        S Watanabe; T Ichimura; N Fujita; S Tsuruzoe; L Ohki; M Shirakawa; M Kawasuji; M Nakao
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 2003, Peer-reviewed

      Presentations

      • DNAメチル化の構造生物学とIn-NMRによる細胞内でのタンパク質と薬剤の相互作用の観察
        白川 昌宏
        日本薬学会医薬化学部会 第３２回メディシナルケミストリーシンポジウム, 27 Nov. 2015, Invited
      • 光検出磁気共鳴法による細胞・生体の高分解能イメージング
        白川 昌宏
        大阪大学蛋白質研究所セミナー 先端核磁気共鳴から展開する生命科学研究, 28 Apr. 2015, Invited
      • D. melanogaster由来APエンドヌクレアーゼCG1218-PAのポリADPリボース(pADPr)結合Znフィンガー(PDZ)ドメインの立体構造とpADPrとの相互作用
        白川 昌宏
        第87回日本生化学会, 16 Oct. 2014, Invited
      • ユビキチン化による細胞内タンパク質の物理化学的排除
        白川 昌宏
        国際高等研究所 第１回研究会, 10 Sep. 2014
      • ポリユビキチンの安定性と構築性—ポリユビキチン鎖の鎖状依存的なダイナミクス
        白川 昌宏
        第36回日本分子生物学会, 05 Dec. 2013, Invited
      • Magnetic Resonance for Investigation of structure and dynamics of proteins and membranes in live cells
        Masahiro Shirakawa
        The 25th International Conference on Magnetic Resonance in Biological Systems, 20 Aug. 2012, Invited
      • In-Cell NMR Spectroscopy of Proteins Inside Living Cells” Keystone Symposium on Frontiers of NMR in Biology
        Masahiro Shirakawa
        Keystone symposia, 15 Jan. 2012, Invited

      Industrial Property Rights

      • 特開WO/20141058012, 特願2014-540890, ナノダイヤモンド粒子およびその製造方法、ならびに蛍光プローブおよびタンパク質の構造解析方法
        白川 昌宏; 外間進悟; 五十嵐龍治; 原田慶恵
      • 特許第5476206号, 特開2011-180570, 特願2010-109527, 蛍光顕微鏡装置
        白川 昌宏; 原田 慶恵; 横田 浩章; 吉成 洋祐; 辻 成悟
      • 特開2009-077710, 特願2008-228433, 基質プローブ、多重核磁気共鳴法による酵素活性の検出方法および酵素活性のイメージング方法
        山内 文生; 矢野 哲哉; 吉村 公博; 久家 克明; 白川 昌宏; 青山 安宏; 山東 信介
      • 特許US74000144, 特開2007-232596, 特願2006-055443, 磁気共鳴力顕微鏡
        辻成悟; 吉成洋祐; 白川昌宏
      • 特開2006-246736, 特願2005-064852, 非破壊的な遺伝子発現モニタリング技術を活用したハイスループット型薬物スクリーニング手法
        古久保 哲朗; 白川 昌宏; 杉原 文徳
      • 特開2006-158228, 特願2004-350635, ヒトVps4bのMITドメインと二価または三価の金属イオンの複合体の構造的特徴およびヒトVps4bのMITドメインによるホスファチジルイノシトールリン酸認識機構
        高須 博敏; 廣明 秀一; 白川 昌宏
      • 特開2006-042732, 特願2004-231652, 酵母DSK2のユビキチン結合ドメインとモノユビキチンとの複合体の構造的特徴および酵母DSK2のユビキチン結合ドメインによるモノユビキチン認識機構
        大野 綾子; 廣明 秀一; 白川 昌宏
      • 特開2005-052021, 特願2003-206609, インターロイキン−18変異体タンパク質
        白川 昌宏; 加藤 善一郎; 近藤 直実
      • 特開2003-207508, 特願2002-002396, 遺伝子発現のモニタリング方法
        古久保 哲朗; 白川 昌宏; ジェレミー・ロビン・ハワード・テイム

      External funds: Kakenhi

      • ダイヤモンドNV中心の量子状態高度制御による量子センシング顕微鏡計測研究
        Grant-in-Aid for Scientific Research (A)
        Medium-sized Section 29:Applied condensed matter physics and related fields
        Kyoto University
        水落 憲和
        From 05 Apr. 2021, To 31 Mar. 2024, Granted
        量子センシング;ダイヤモンド;NV中心;NMR;バイオ計測;NVセンタ;CVDダイヤモンド合成;n型ダイヤモンド
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04653/
      • Dynamic control of centromere and telomere function by the SUMO modification system
        Grant-in-Aid for Scientific Research (B)
        Basic Section 38060:Applied molecular and cellular biology-related
        Kwansei Gakuin University
        Katsunori Tanaka
        From 01 Apr. 2020, To 31 Mar. 2023, Project Closed
        タンパク質翻訳後修飾;SUMO;セントロメア;テロメア;染色体機能;分裂酵母
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H02952/
      • Investigation the functional expression mechanisms of intracellular liquid droplets using in-cell magnetic resonance methods
        Grant-in-Aid for Scientific Research (A)
        Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
        Kyoto University
        白川 昌宏
        From 01 Apr. 2020, To 31 Mar. 2023, Granted
        ダイアモンド;相分離;線維化;液滴;液液相分離;量子センサー;光検出磁気共鳴法(ODMR);アミロイド;磁気共鳴法;液-液相分離;一分子測定;液液位相分離
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20H00453/
      • 「動的構造生命科学を拓く新発想測定技術」の成果取りまとめを目指した組織活動
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Complex systems
        Kyushu University
        神田 大輔
        From 01 Apr. 2019, To 31 Mar. 2020, Project Closed
        動的構造;構造生命科学;新測定技術;蛋白質
        https://kaken.nii.ac.jp/grant/KAKENHI-WRAPUP-19H05452/
      • Intra-nucleic and genomic distributions of liquid droplets formed by liquid-liquid phase separations
        Grant-in-Aid for Challenging Research (Exploratory)
        Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
        Kyoto University
        Masahiro Shirakawa
        From 29 Jun. 2018, To 31 Mar. 2021, Project Closed
        量子センシング;光検出磁気共鳴;１分子観察;ナノ粒子;光検出磁気共鳴法;ナノダイヤモンド;細胞内温度計測;細胞内粘度計測;高分解能イメージング;液滴様構造体;ODMR-FIONA;エピジェネティックス;液液相分離;細胞分化
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K19297/
      • Support activities aimed at international network formation in the research area of dynamic structural life sciences
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Complex systems
        Kyushu University
        Daisuke Kohda
        From 06 Nov. 2015, To 31 Mar. 2019, Project Closed
        国際共同研究;海外派遣;海外研究者受入;海外講演者招聘;海外研究者招聘;海外共同研究者受入
        https://kaken.nii.ac.jp/grant/KAKENHI-INTERNATIONAL-15K21711/
      • Development of analyzing methods for protein-protein interactions and protein dynamics by means of ODMR and in-cell NMR
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Complex systems
        Kyoto University
        Masahiro Shirakawa
        From 10 Jul. 2014, To 31 Mar. 2019, Project Closed
        ODMR;in-cell NMR;細胞内蛋白質;細胞小器官;Rheo-NMR;in cell NMR
        https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-26119004/
      • New measurement techniques for visualizing live protein molecules at work
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Complex systems
        Kyushu University
        Daisuke Kohda
        From 10 Jul. 2014, To 31 Mar. 2019, Project Closed
        蛋白質;動的構造;測定技術;NMR;AFM;ODMR;結晶解析;計算シミュレーション;タンパク質;X線結晶解析;計算科学;ＮＭＲ;ＡＦＭ;X線結晶学;Ｘ線結晶学
        https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-26119001/
      • Structure basis of maintenance DNA methylation
        Grant-in-Aid for Scientific Research (A)
        Kyoto University
        Masahiro SHIRAKAWA
        From 01 Apr. 2009, To 31 Mar. 2012, Project Closed
        DNAメチル化;エピジェネティック;ヒストン;X線結晶解析;NMR;エピジェネティクス;ヒストン修飾;構造生物学
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21247013/
      • Analyses of the activation mechanisms of receptors of fatty acids and membrane receptors by in situ measurement
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Complex systems
        Kyoto University
        Masahiro SHIRAKAWA
        From 01 Apr. 2009, To 31 Mar. 2015, Project Closed
        NMR;脂質シャペロン;脂肪酸結合蛋白質;In-cell NMR;19F NMR;細胞生物学;FKBP12;FK506;ラパマイシン;立体構造;細胞計測;ESR;X線結晶法
        https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-21121006/
      • Integrative understanding of biological processes mediated by transient macromolecul ar complexes; New technology for visualizing physiologically metastable states
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Complex systems
        The University of Tokyo
        Ichio SHIMADA
        From 23 Jul. 2009, To 31 Mar. 2014, Project Closed
        領域とりまとめ;構造生物学;核磁気共鳴法;X線結晶構造解析;一分子計測学;ケミカルバイオロジー;Ｘ線結晶構造解析;ケミカル・バイオロジ;ケミカルバイオロジ
        https://kaken.nii.ac.jp/grant/KAKENHI-ORGANIZER-21121001/
      • Structural basis for protein functional transfer by SUMOylation
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Masahiro SHIRAKAWA
        From 01 Apr. 2006, To 31 Mar. 2008, Project Closed
        SUMO;立体構造;NMR;X線結晶法;X線結晶構造;X線結晶構造解析法;DNA結合たんぱく質, SUMO;protein modification;structure;NMR;DNA methylation
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18370040/
      • タンパク質タグの付加による細胞内タンパク質の局在・機能変換の構造学的研究
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University;Yokohama City University
        杤尾 豪人
        From 01 Apr. 2005, To 31 Mar. 2007, Project Closed
        ユビキチン;SUMO;構造生物学;タンパク質タグ;翻訳後修飾;NMR
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17028046/
      • Structural and functional studies of SUMO ylation and poly-ubiquitination
        Grant-in-Aid for Scientific Research (B)
        Kyoto University
        Masahiro SHIRAKAWA
        From 01 Apr. 2004, To 31 Mar. 2006, Project Closed
        SUMO;DNA修復;立体構造解析;構造変化;X線結晶法;ユビキチン;ポリユビキチン;NMR;立体構造, SUMO;protein modification;DNA repair;protein structure determination;X-ray crystallography
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16370052/
      • Structural study of signal transduction by membrane receptors through protein-protein interactions
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Kyoto University;Yokohama City University
        Masahiro SHIRAKAWA
        From 01 Apr. 2003, To 31 Mar. 2009, Project Closed
        NMR;結晶構造解析;膜たんぱく質;免疫;膜受容体;立体構造;X線結晶構造解析法;インターロイキン;膜蛋白質;小胞輸送;SUMO;G蛋白質共役受容体;生理活性ペプチド;細胞内輸送;ペロキシソーム;ユビキチン
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15083102/
      • Molecular soft interactions regulating membrane-interface activities in living systems
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Osaka University
        Hideo AKUTSU
        From 01 Apr. 2003, To 31 Mar. 2010, Project Closed
        膜インターフェイス;生命秩序;ソフトな分子間相互作用;膜タンパク質;シグナル伝達;物質輸送;核磁気共鳴法(NMR);X線結晶構造解析;ソフトな相互作用;分子間相互作用
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15083101/
      • プロテアソームS5aサブユニットによるポリユビキチン鎖認識の立体構造学的研究
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Yokohama City University
        杤尾 豪人
        From 01 Apr. 2003, To 31 Mar. 2005, Project Closed
        蛋白質分解;ユビキチン;プロテアソーム;NMR;ユビキチン結合モチーフ
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15032248/
      • プロテオソームS5aサブユニットによるユビキチン様ドメイン認識の構造学的研究
        Grant-in-Aid for Scientific Research on Priority Areas
        Biological Sciences
        Yokohama City University
        杤尾 豪人
        From 01 Apr. 2002, To 31 Mar. 2003, Project Closed
        蛋白質;蛋白質分解;ユビキチン
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14037261/
      • 新規in vivo可視化技術を用いた真核細胞における遺伝情報発現機構の解析
        Grant-in-Aid for Creative Scientific Research
        Yokohama City University
        古久保 哲朗
        From 01 Apr. 2001, To 31 Mar. 2006, Project Closed
        転写調節;モニタリング;遺伝子発現;イメージング;NMR;MRI;ポリリン酸;レポーター遺伝子
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13GS0013/
      • Structural basis for regulation of chromatin structure by DNA methylation
        Grant-in-Aid for Scientific Research (B)
        Yokohama City University
        Masahiro SHIRAKAWA
        From 01 Apr. 2001, To 31 Mar. 2004, Project Closed
        DNAメチル化;ユビキチン化;NMR;DNA修復;クロマチン;動的構造;ヒストン メチル;メチル化DNA結合蛋白質;クロマチン構造;エピジェネティックス;転写;ヒストン メチル化;メチル化DNA;メチル化DNA結合ドメイン;立体構造;ミスマッチDNA, DNA methylation;ubiquitination;DNA repair;NMR
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13480230/
      • NMR methods for determination of proteins : obtaining Information of long distances
        Grant-in-Aid for Scientific Research (C)
        NARA INSTITUTE OF SCIENCE AND TECHNOLOGY
        Masao SHIRAKAWA
        From 01 Apr. 1999, To 31 Mar. 2001, Project Closed
        水素結合;NMR;双極子-双極子相互作用;立体構造;ヌクレオチド結合蛋白質;Ras蛋白質;ヌクレオチド, Hydrogen bonds;NMR;residual dipolar couplings;strueture determination
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11680662/
      • 酸化DNA修復酵素MutM,OGG1,MTH1の立体構造解析
        Grant-in-Aid for Scientific Research on Priority Areas (A)
        Nara Institute of Science and Technology
        池上 貴久
        From 01 Apr. 1999, To 31 Mar. 2000, Project Closed
        核磁気共鳴;NMR;立体構造;8-オキソグアニン;修復酵素;活性酸素;MTH1;DNA損傷
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11146213/
      • Protein-protein interaction in intracellular signal transduction
        Grant-in-Aid for Scientific Research on Priority Areas (A)
        Biological Sciences
        HOKKAIDO UNIVERSITY;Tokyo Metropolitan Organization for Medical Research
        Fuyuhiko INAGAKI
        From 01 Apr. 1998, To 31 Mar. 2002, Project Closed
        情報伝達;蛋白質間相互作用;細胞質内シグナル伝達;核内シグナル伝達;新規NMR技術;班会議;シンポジウム;ワークショップ;備品整備;班研究会;フィロポディア;二成分系;リン酸基転移反応;嫌気センサー, signal transduction;protein-protein interaction;intracellular signal transduction;nuclear signal transduction;novel NMR techniques
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10179103/
      • Roles of protein-protein interactions in nuclear signal transductions
        Grant-in-Aid for Scientific Research on Priority Areas (A)
        Biological Sciences
        Yokohama City University;Nara Institute of Science and Technology
        Masahiro SHIRAKAWA
        From 01 Apr. 1998, To 31 Mar. 2002, Project Closed
        DNA結合蛋白質;転写因子;蛋白質構造;核磁気共鳴法;DNAメチル化;X線結晶構造解析;転写;蛋白質;立体構造;遺伝子修復;NMR;基本転写因子;クロマチン;DNA結;G蛋白質共役受容体;水素結合;X線;蛋白質-蛋白質相互作用;蛋白質の立体構造, transcription;protein structure;chromatin;NMR;X-ray crystallography
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10179102/
      • ヒトXPA蛋白質のRPA,及び損傷DNAとの複合体の立体構造解析
        Grant-in-Aid for Scientific Research on Priority Areas (A)
        Nara Institute of Science and Technology
        池上 貴久
        From 01 Apr. 1998, To 31 Mar. 1999, Project Closed
        色素性乾皮症;XPA;核磁気共鳴;NMR;RPA;損傷DNA;遺伝子修復;ヌクレオチド除去修復
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10165216/
      • 構造生物学にもとづくシグナル伝達機構の解明
        Grant-in-Aid for Scientific Research (C)
        Tokyo Metropolitan Organization for Medical Research
        稲垣 冬彦
        From 01 Apr. 1997, To 31 Mar. 1998, Project Closed
        多元的情報伝達;細胞質内シグナル;核内シグナル;N-WASP;モエシン;低分子量G蛋白;コアクチベータ;CBP
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09898022/
      • Tertiary structure of transcriptional co-activators.
        Grant-in-Aid for Scientific Research (C)
        Nara Institute of Science and Technology
        Masahiro SHIRAKAWA
        From 01 Apr. 1997, To 31 Mar. 1999, Project Closed
        立体構造;転写因子;NMR;蛋白質;蛋白質間相互作用;DNA系〓〓〓蛋白質;DNA結合蛋白質;遺伝子転写;蛋白質-蛋白質相互作用, tertiary structure;transcription factor;NMR;Protein;protein-protein interaction;DNA binding protein
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09680652/
      • ヒトDNA修復因子XPAの損傷DNA結合ドメインの溶液中での立体構造解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Nara Institute of Science and Technology
        白川 昌宏
        From 01 Apr. 1997, To 31 Mar. 1998, Project Closed
        DNA修復;立体構造;DNA結合蛋白質;NMR;Znフィンガー
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09269218/
      • 低分子量G蛋白質とその標的蛋白質の相互作用の構造解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Nara Institute of Science and Technology
        黒田 真也
        From 01 Apr. 1997, To 31 Mar. 1998, Project Closed
        低分子量G蛋白質;AF-6;Rho-kinase;IQGAPl
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09249214/
      • 低分子量G蛋白質PhoとProtein kinase Nの複合体の立体構造解析
        Grant-in-Aid for Encouragement of Young Scientists (A)
        Nara Institute of Science and Technology
        白川 昌宏
        From 01 Apr. 1996, To 31 Mar. 1997, Project Closed
        低分子量G蛋白質;NMR;細胞骨格;Pho
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08780655/
      • ヒト遺伝子修復蛋白質XPAの損傷DNA特異的結合ドメインの立体構造解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Nara Institute of Science and Technology
        白川 昌宏
        From 01 Apr. 1996, To 31 Mar. 1997, Project Closed
        DNA修復;立体構造;NMR;色素性乾皮症;Znフィンガー
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08280219/
      • 低分子量G蛋白質とその標的蛋白質の相互作用の構造解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Nara Institute of Science and Technology
        黒田 真也
        From 01 Apr. 1996, To 31 Mar. 1997, Project Closed
        低分子量G蛋白質;Rho kinase;coiled coil;細胞骨格;PDZドメイン;細胞接着
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08260215/
      • 真核生物の転写調節因子複合体の溶液中での立体構造解析
        Grant-in-Aid for Scientific Research on Priority Areas
        Nara Institute of Science and Technology
        白川 昌宏
        From 01 Apr. 1996, To 31 Mar. 1997, Project Closed
        遺伝子転写;転写メディエーター;コアクチベータ-;立体構造;NMR
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08250218/
      • λファージCro蛋白質の2量体間S-S結合架橋変異体の立体構造解析
        Grant-in-Aid for Encouragement of Young Scientists (A)
        Nara Institute of Science and Technology
        白川 昌宏
        From 01 Apr. 1995, To 31 Mar. 1996, Project Closed
        リプレッサー;DNA結合蛋白質;NMR;蛋白工学
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07780574/
      • 真核生物の転写調節因子の立体構造決定と制御配列DNA分子認識に関する構造=的研究
        Grant-in-Aid for Scientific Research on Priority Areas
        Nara Institute of Science and Technology
        白川 昌宏
        From 01 Apr. 1995, To 31 Mar. 1996, Project Closed
        遺伝子転写調節;立体構造解析;DNA結合蛋白質;NMR
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07258213/
      • PEBP-2のDNA結合:ヘテロダイマー形成の構造学的研究
        Grant-in-Aid for Encouragement of Young Scientists (A)
        Osaka University
        白川 昌宏
        From 01 Apr. 1994, To 31 Mar. 1995, Project Closed
        NMR;DNA結合蛋白質;立体構造解析;PEBP2;転写制御;ヘテロダイマー
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06780534/
      • Analyses of Signal Transduction Mechanisms based on Protein Structures
        Grant-in-Aid for Scientific Research on Priority Areas
        Yokohama City University
        Yoshifumi NISHIMURA
        From 01 Apr. 1994, To 31 Mar. 1999, Project Closed
        蛋白質;高次構造;構造生物学;NMR;X線結晶;転写因子;シグナル伝達;分子認識, Structural Biology;X-ray Crystallography;NMR;Signal Transduction;Transcription;DNA-binding Proteins;RNA-binding Proteins;Molecular Biology
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06276103/
      • Development of Novel Methods for Structural Analyses of Proteins
        Grant-in-Aid for Scientific Research on Priority Areas
        Osaka University
        Saburo AIMOTO
        From 01 Apr. 1994, To 31 Mar. 1998, Project Closed
        蛋白質;高次構造;解析法;蛋白質・核酸相互作用;NMR;固体NMR;化学合成;X線結晶構造解析, Protein;3-dimensional Structure;Analytical Method;Protein Nucleic Acid Interaction;NMR;Solid-state NMR;Chemical Synthesis;X-ray Crystallography
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06276102/
      • インターフェロン遺伝子転写調節因子と制御配列DNAの分子認識に関する構造学的研究
        Grant-in-Aid for Scientific Research on Priority Areas
        Osaka University
        白川 昌宏
        From 01 Apr. 1994, To 31 Mar. 1995, Project Closed
        NMR;DNA結合蛋白質;立体構造解析;インターフェロン;転写制御;POU-ホメオドメイン
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06266209/
      • マウスOct-3蛋白質のPOUドメインの立体構造とサブドメイン構造の解析
        Grant-in-Aid for Encouragement of Young Scientists (A)
        Osaka University
        白川 昌宏
        From 01 Apr. 1993, To 31 Mar. 1994, Project Closed
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05780480/
      • 蛋白質の高次構造に基づくシグナル認識機構の解明
        Yokohama City University
        西村 善文
        From 01 Apr. 1993, To 31 Mar. 1994, Project Closed
        蛋白質;NMR;X線;高次構造;DNA;転写因子;シグナル伝達;相互作用
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05354030/
      • インターフェロン遺伝子転写調節因子の高次構造と制御塩基配列認識機構の研究
        Grant-in-Aid for Scientific Research on Priority Areas
        Osaka University
        白川 昌宏
        From 01 Apr. 1993, To 31 Mar. 1994, Project Closed
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05273213/
      • 組換えの際に生じるDNA構造と蛋白質による識別
        Grant-in-Aid for Scientific Research on Priority Areas
        Osaka University
        白川 昌宏
        From 01 Apr. 1993, To 31 Mar. 1994, Project Closed
        DNA構造;Hollidayジャンクション;組換え;核磁気共鳴;十字構造;電気泳動;RuvC;相互作用
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05255204/
      • 制御蛋白質の機能構造
        Grant-in-Aid for Scientific Research on Priority Areas
        Nagoya University
        饗場 弘二
        From 01 Apr. 1991, To 31 Mar. 1992, Project Closed
        DNA結合蛋白質;転写制御蛋白質;タンパク質の機能構造;タンパク質のドメイン;立体構造;DNAー蛋白質相互作用;蛋白質ー蛋白質相互作用;DNAの構造変化
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03259101/
      • 制御蛋白質の機能構造
        Grant-in-Aid for Scientific Research on Priority Areas
        Nagoya University
        饗場 弘二
        From 01 Apr. 1990, To 31 Mar. 1993, Project Closed
        DNA結合蛋白質;転写制御蛋白質;タンパク質の機能構造;タンパク質のドメイン;立体構造;DNA-蛋白質相互作用;蛋白質-蛋白質相互作用;DNAの構造変化
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04254101/
      • 制御蛋白質の機能構造
        Grant-in-Aid for Scientific Research on Priority Areas
        University of Tsukuba
        饗場 弘二
        From 01 Apr. 1990, To 31 Mar. 1991, Project Closed
        DNA結合蛋白質;制御蛋白質;転写制御;機能構造;蛋白質のドメイン;立体構造;DNAー蛋白質相互作用;DNAの構造変化
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02263101/
      • Regulation mechanism of intra-nuclear reactions studied by nanoscale magnetic resonance
        Grant-in-Aid for Scientific Research (A)
        Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
        Kyoto University
        白川 昌宏
        From 01 Apr. 2023, To 31 Mar. 2026, Declined
        量子センシング;ナノダイヤモンド;光検出磁気共鳴;液-液相分離;核内反応制御
        https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H00370/

      External funds: others

      • 幹細胞における多分解性維持の分子機構と エピゲノム構造の三次元的解析
        独立行政法人科学技術振興機構
        From 01 Dec. 2011, To 31 Mar. 2017
        白川昌宏
      • 細胞内におけるSOD1タンパク質の構造・ 運動性解析による神経変性疾患の発症機構の解明
        独立行政法人科学技術振興機構本部長(国際担当)　高松明)
        From 01 Apr. 2011, To 31 Mar. 2014
        白川昌宏
      list
        Last Updated :2025/05/02

        Education

        Teaching subject(s)

        • From Apr. 2011, To Mar. 2012
          物理化学III（工業基礎化学）［T15・T18］
          Fall, 工学部
        • From Apr. 2011, To Mar. 2012
          物理化学III（工業基礎化学）［T16・T17］
          Fall, 工学部
        • From Apr. 2011, To Mar. 2012
          化学から生物へ生物から化学へ
          Fall, 工学研究科
        • From Apr. 2011, To Mar. 2012
          Scientific English
          Fall, 全学共通科目
        • From Apr. 2012, To Mar. 2013
          Advanced Seminar on Molecular Engineering 1
          Spring, 工学研究科
        • From Apr. 2012, To Mar. 2013
          Advanced Seminar on Molecular Engineering 2
          Fall, 工学研究科
        • From Apr. 2012, To Mar. 2013
          Laboratory and Exercises in Molecular Engineering II
          Year-long, 工学研究科
        • From Apr. 2012, To Mar. 2013
          Laboratory and Exercises in Molecular Engineering I
          Year-long, 工学研究科
        • From Apr. 2012, To Mar. 2013
          Advanced Molecular Engineering
          Fall, 工学研究科
        • From Apr. 2012, To Mar. 2013
          Molecular Engineering, Adv. I
          Spring, 工学研究科
        • From Apr. 2012, To Mar. 2013
          Molecular Engineering, Adv. III
          Fall, 工学研究科
        • From Apr. 2012, To Mar. 2013
          Molecular Engineering, Adv. II
          Fall, 工学研究科
        • From Apr. 2012, To Mar. 2013
          Molecular Engineering, Adv. IV
          Year-long, 工学研究科
        • From Apr. 2012, To Mar. 2013
          Physical Chemistry III (Fundamental Chemistry)
          Fall, 工学部
        • From Apr. 2012, To Mar. 2013
          Biomolecular Function Chemistry
          Spring, 工学研究科
        • From Apr. 2012, To Mar. 2013
          Master's Thesis
          Year-long, 工学研究科
        • From Apr. 2012, To Mar. 2013
          Scientific English
          Fall, 全学共通科目
        • From Apr. 2013, To Mar. 2014
          Physical Chemistry III (Fundamental Chemistry)
          Fall, 工学部
        • From Apr. 2013, To Mar. 2014
          Frontiers in the Field of Chemical Biology and Biological Chemistry
          Fall, 工学研究科
        • From Apr. 2013, To Mar. 2014
          Scientific English
          Fall, 全学共通科目
        • From Apr. 2014, To Mar. 2015
          Physical Chemistry III (Fundamental Chemistry)
          Fall, 工学部
        • From Apr. 2014, To Mar. 2015
          Biomolecular Function Chemistry
          Spring, 工学研究科
        • From Apr. 2014, To Mar. 2015
          Scientific English
          Fall, 全学共通科目
        • From Apr. 2015, To Mar. 2016
          Physical Chemistry III (Fundamental Chemistry)
          Fall, 工学部
        • From Apr. 2015, To Mar. 2016
          Advanced Seminar on Materials Engineering and Chemistry III
          Spring, 工学研究科
        • From Apr. 2015, To Mar. 2016
          Advanced Seminar on Materials Engineering and Chemistry II
          Fall, 工学研究科
        • From Apr. 2015, To Mar. 2016
          Advanced Seminar on Materials Engineering and Chemistry IV
          Fall, 工学研究科
        • From Apr. 2015, To Mar. 2016
          Advanced Seminar on Materials Engineering and Chemistry I
          Spring, 工学研究科
        • From Apr. 2015, To Mar. 2016
          Advanced Seminar on Materials Engineering and Chemistry VI
          Fall, 工学研究科
        • From Apr. 2015, To Mar. 2016
          Advanced Seminar on Materials Engineering and Chemistry V
          Spring, 工学研究科
        • From Apr. 2015, To Mar. 2016
          Laboratory and Exercise on Materials Engineering and Chemistry III
          Spring, 工学研究科
        • From Apr. 2015, To Mar. 2016
          Laboratory and Exercise on Materials Engineering and Chemistry II
          Fall, 工学研究科
        • From Apr. 2015, To Mar. 2016
          Laboratory and Exercise on Materials Engineering and Chemistry IV
          Fall, 工学研究科
        • From Apr. 2015, To Mar. 2016
          Laboratory and Exercise on Materials Engineering and Chemistry I
          Spring, 工学研究科
        • From Apr. 2015, To Mar. 2016
          Master's Thesis
          Year-long, 工学研究科
        • From Apr. 2015, To Mar. 2016
          Scientific English
          Fall, 工学部
        • From Apr. 2016, To Mar. 2017
          Physical Chemistry III (Fundamental Chemistry)
          Fall, 工学部
        • From Apr. 2016, To Mar. 2017
          Advanced Seminar on Materials Engineering and Chemistry III
          Year-long, 工学研究科
        • From Apr. 2016, To Mar. 2017
          Advanced Seminar on Materials Engineering and Chemistry II
          Year-long, 工学研究科
        • From Apr. 2016, To Mar. 2017
          Advanced Seminar on Materials Engineering and Chemistry IV
          Year-long, 工学研究科
        • From Apr. 2016, To Mar. 2017
          Advanced Seminar on Materials Engineering and Chemistry I
          Year-long, 工学研究科
        • From Apr. 2016, To Mar. 2017
          Advanced Seminar on Materials Engineering and Chemistry VI
          Year-long, 工学研究科
        • From Apr. 2016, To Mar. 2017
          Advanced Seminar on Materials Engineering and Chemistry V
          Year-long, 工学研究科
        • From Apr. 2016, To Mar. 2017
          Laboratory and Exercise on Materials Engineering and Chemistry III
          Spring, 工学研究科
        • From Apr. 2016, To Mar. 2017
          Laboratory and Exercise on Materials Engineering and Chemistry II
          Fall, 工学研究科
        • From Apr. 2016, To Mar. 2017
          Laboratory and Exercise on Materials Engineering and Chemistry IV
          Fall, 工学研究科
        • From Apr. 2016, To Mar. 2017
          Laboratory and Exercise on Materials Engineering and Chemistry I
          Spring, 工学研究科
        • From Apr. 2016, To Mar. 2017
          Biomolecular Function Chemistry
          Spring, 工学研究科
        • From Apr. 2016, To Mar. 2017
          Master's Thesis
          Year-long, 工学研究科
        • From Apr. 2016, To Mar. 2017
          Scientific English
          Fall, 工学部
        • From Apr. 2017, To Mar. 2018
          Bio-Medical Engineering Internship M
          Year-long, 工学研究科
        • From Apr. 2017, To Mar. 2018
          Molecular Engineering, Adv. VI
          Spring, 工学研究科
        • From Apr. 2017, To Mar. 2018
          Physical Chemistry III (Fundamental Chemistry)
          Fall, 工学部
        • From Apr. 2017, To Mar. 2018
          Bio-Medical Engineering Internship D
          Year-long, 工学研究科
        • From Apr. 2017, To Mar. 2018
          Seminar on Bio-Medical Engineering A (MC)
          Spring, 工学研究科
        • From Apr. 2017, To Mar. 2018
          Seminar on Bio-Medical Engineering B (MC)
          Fall, 工学研究科
        • From Apr. 2017, To Mar. 2018
          Seminar on Bio-Medical Engineering A
          Spring, 工学研究科
        • From Apr. 2017, To Mar. 2018
          Seminar on Bio-Medical Engineering B
          Fall, 工学研究科
        • From Apr. 2017, To Mar. 2018
          Seminar on Bio-Medical Engineering C
          Spring, 工学研究科
        • From Apr. 2017, To Mar. 2018
          Seminar on Bio-Medical Engineering D
          Fall, 工学研究科
        • From Apr. 2017, To Mar. 2018
          Experiments and Exercises on Bio-Medical Engineering, Adv. I
          Year-long, 工学研究科
        • From Apr. 2017, To Mar. 2018
          Experiments and Exercises on Bio-Medical Engineering, Adv. II
          Year-long, 工学研究科
        • From Apr. 2017, To Mar. 2018
          Master's Thesis
          Year-long, 工学研究科
        • From Apr. 2017, To Mar. 2018
          Scientific English
          Fall, 工学部
        • From Apr. 2018, To Mar. 2019
          Physical Chemistry III (Fundamental Chemistry)
          Fall, 工学部
        • From Apr. 2018, To Mar. 2019
          Biomolecular Function Chemistry
          Spring, 工学研究科
        • From Apr. 2018, To Mar. 2019
          Scientific English
          Fall, 工学部
        • From Apr. 2019, To Mar. 2020
          Advanced Seminar on Molecular Engineering 1
          Spring, 工学研究科
        • From Apr. 2019, To Mar. 2020
          Advanced Seminar on Molecular Engineering 2
          Fall, 工学研究科
        • From Apr. 2019, To Mar. 2020
          Laboratory and Exercises in Molecular Engineering II
          Year-long, 工学研究科
        • From Apr. 2019, To Mar. 2020
          Laboratory and Exercises in Molecular Engineering I
          Year-long, 工学研究科
        • From Apr. 2019, To Mar. 2020
          Advanced Molecular Engineering
          Fall, 工学研究科
        • From Apr. 2019, To Mar. 2020
          Molecular Engineering, Adv. IA
          Spring, 工学研究科
        • From Apr. 2019, To Mar. 2020
          Molecular Engineering, Adv. IB
          Fall, 工学研究科
        • From Apr. 2019, To Mar. 2020
          Molecular Engineering, Adv. VII
          Spring, 工学研究科
        • From Apr. 2019, To Mar. 2020
          Molecular Engineering, Adv. III
          Fall, 工学研究科
        • From Apr. 2019, To Mar. 2020
          Frontiers in the Field of Chemical Biology and Biological Chemistry
          Fall, 工学研究科
        • From Apr. 2019, To Mar. 2020
          Physical Chemistry III (Fundamental Chemistry)
          Fall, 工学部
        • From Apr. 2019, To Mar. 2020
          Scientific English
          Fall, 工学部
        • From Apr. 2020, To Mar. 2021
          Biomolecular Function Chemistry
          Spring, 工学研究科
        • From Apr. 2020, To Mar. 2021
          Scientific English
          Fall, 工学部
        • From Apr. 2021, To Mar. 2022
          Frontiers in the Field of Chemical Biology and Biological Chemistry
          Fall, 工学研究科
        • From Apr. 2021, To Mar. 2022
          Scientific English
          Fall, 工学部

        Part-time lecturer

        • From 06 Apr. 2018, To 24 Mar. 2019
          徳島大学
        • From 06 Apr. 2019, To 24 Mar. 2020
          徳島大学
        • From 06 Apr. 2020, To 24 Mar. 2021
          国立大学法人徳島大学
        • From 05 Apr. 2021, To 24 Mar. 2022
          国立大学法人徳島大学
        list
          Last Updated :2025/05/02

          Administration

          Faculty management (title, position)

          • To 30 Sep. 2014
            工学研究科動物実験委員会　委員
          • From 01 Apr. 2015, To 31 Mar. 2019
            工学研究科教育制度委員会　委員
          • To 30 Sep. 2016
            工学研究科動物実験委員会　委員
          • From 01 Apr. 2016, To 31 Mar. 2018
            工学研究科国際交流委員会　委員
          • From 01 Apr. 2019, To 31 Mar. 2020
            分子工学専攻長

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