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Takayama, Kazuo

Center for iPS Cell Research and Application (CiRA) Senior Lecturer/ Junior Associate Professor

Takayama, Kazuo
list
    Last Updated :2022/06/30

    Basic Information

    Academic Degree

    • 修士(薬科学)(大阪大学)
    • 博士(薬科学)(大阪大学)

    Research History

    • From Mar. 2020, To Present
      京都大学iPS細胞研究所, 講師
    • From Oct. 2016, To Mar. 2020
      さきがけ研究者
    • From Feb. 2018, To Feb. 2020
      Osaka University, Graduate School of Pharmaceutical Sciences, 助教
    • From Apr. 2015, To Jan. 2018
      Osaka University, Graduate School of Pharmaceutical Sciences, Drug Innovation Center, 特任助教
    • From Nov. 2015, To Mar. 2017
      K-CONNEX研究者

    Language of Instruction

    • Japanese
    • English

    ID,URL

    researchmap URL

    list
      Last Updated :2022/06/30

      Research

      Research Interests

      • organs-on-a-chip
      • SARS-CoV-2
      • iPS cells
      • pluripotent stem cells
      • drug discovery

      Papers

      • Cell response analysis in SARS-CoV-2 infected bronchial organoids
        Emi Sano; Tatsuya Suzuki; Rina Hashimoto; Yumi Itoh; Ayaka Sakamoto; Yusuke Sakai; Akatsuki Saito; Daisuke Okuzaki; Daisuke Motooka; Yukiko Muramoto; Takeshi Noda; Tomohiko Takasaki; Jun-Ichi Sakuragi; Shohei Minami; Takeshi Kobayashi; Takuya Yamamoto; Yasufumi Matsumura; Miki Nagao; Toru Okamoto; Kazuo Takayama
        Communications Biology, Dec. 2022, Peer-reviewed
      • Dual inhibition of TMPRSS2 and Cathepsin Bprevents SARS-CoV-2 infection in iPS cells.
        Rina Hashimoto; Ayaka Sakamoto; Sayaka Deguchi; Renxing Yi; Emi Sano; Akitsu Hotta; Kazutoshi Takahashi; Shinya Yamanaka; Kazuo Takayama
        Molecular therapy. Nucleic acids, 03 Dec. 2021
      • Clinical utility of novel biosensing platform: Diagnosis of coronavirus SARS-CoV-2 at point of care.
        Alaa A A Aljabali; Kaushik Pal; Angel Serrano-Aroca; Kazuo Takayama; Kamal Dua; Murtaza M Tambuwala
        Materials letters, 01 Dec. 2021
      • Protective Face Masks: Current Status and Future Trends.
        Alberto Tuñón-Molina; Kazuo Takayama; Elrashdy M Redwan; Vladimir N Uversky; Juan Andrés; Ángel Serrano-Aroca
        ACS applied materials & interfaces, 19 Nov. 2021
      • Generation of Tetrafluoroethylene-Propylene Elastomer-Based Microfluidic Devices for Drug Toxicity and Metabolism Studies.
        Emi Sano; Sayaka Deguchi; Naoki Matsuoka; Masahiro Tsuda; Mengyang Wang; Kaori Kosugi; Chihiro Mori; Keisuke Yagi; Aya Wada; Shinsuke Yamasaki; Tsuyoshi Kawai; Masahide Yodogawa; Hiroyuki Mizuguchi; Norihito Nakazawa; Fumiyoshi Yamashita; Yu-Suke Torisawa; Kazuo Takayama
        ACS omega, 28 Sep. 2021
      • Potential Molecular Mechanisms of Rare Anti-Tumor Immune Response by SARS-CoV-2 in Isolated Cases of Lymphomas.
        Debmalya Barh; Sandeep Tiwari; Lucas Gabriel Rodrigues Gomes; Marianna E Weener; Khalid J Alzahrani; Khalaf F Alsharif; Alaa A A Aljabali; Murtaza M Tambuwala; Kenneth Lundstrom; Sk Sarif Hassan; Ángel Serrano-Aroca; Kazuo Takayama; Preetam Ghosh; Elrashdy M Redwan; Bruno Silva Andrade; Siomar de Castro Soares; Vasco Azevedo; Vladimir N Uversky
        Viruses, 25 Sep. 2021
      • Implications derived from S-protein variants of SARS-CoV-2 from six continents.
        Sk Sarif Hassan; Kenneth Lundstrom; Debmalya Barh; Raner Jośe Santana Silva; Bruno Silva Andrade; Vasco Azevedo; Pabitra Pal Choudhury; Giorgio Palu; Bruce D Uhal; Ramesh Kandimalla; Murat Seyran; Amos Lal; Samendra P Sherchan; Gajendra Kumar Azad; Alaa A A Aljabali; Adam M Brufsky; Ángel Serrano-Aroca; Parise Adadi; Tarek Mohamed Abd El-Aziz; Elrashdy M Redwan; Kazuo Takayama; Nima Rezaei; Murtaza Tambuwala; Vladimir N Uversky
        International journal of biological macromolecules, 24 Sep. 2021
      • Periodically aperiodic pattern of SARS-CoV-2 mutations underpins the uncertainty of its origin and evolution.
        Sk Sarif Hassan; Pallab Basu; Elrashdy M Redwan; Kenneth Lundstrom; Pabitra Pal Choudhury; Angel Serrano-Aroca; Gajendra Kumar Azad; Alaa A A Aljabali; Giorgio Palu; Tarek Mohamed Abd El-Aziz; Debmalya Barh; Bruce D Uhal; Parise Adadi; Kazuo Takayama; Nicolas G Bazan; Murtaza Tambuwala; Amos Lal; Gaurav Chauhan; Wagner Baetas-da-Cruz; Samendra P Sherchan; Vladimir N Uversky
        Environmental research, 22 Sep. 2021
      • Antiviral Face Mask Functionalized with Solidified Hand Soap: Low-Cost Infection Prevention Clothing against Enveloped Viruses Such as SARS-CoV-2.
        Alba Cano-Vicent; Alberto Tuñón-Molina; Miguel Martí; Yukiko Muramoto; Takeshi Noda; Kazuo Takayama; Ángel Serrano-Aroca
        ACS omega, 14 Sep. 2021
      • Autoimmunity roots of the thrombotic events after COVID-19 vaccination.
        Fatma Elrashdy; Murtaza M Tambuwala; Sk Sarif Hassan; Parise Adadi; Murat Seyran; Tarek Mohamed Abd El-Aziz; Nima Rezaei; Amos Lal; Alaa A A Aljabali; Ramesh Kandimalla; Nicolas G Bazan; Gajendra Kumar Azad; Samendra P Sherchan; Pabitra Pal Choudhury; Ángel Serrano-Aroca; Kazuo Takayama; Gaurav Chauhan; Damiano Pizzol; Debmalya Barh; Pritam Kumar Panda; Yogendra K Mishra; Giorgio Palù; Kenneth Lundstrom; Elrashdy M Redwan; Vladimir N Uversky
        Autoimmunity reviews, 09 Sep. 2021
      • Antimicrobial Face Shield: Next Generation of Facial Protective Equipment against SARS-CoV-2 and Multidrug-Resistant Bacteria.
        Alberto Tuñón-Molina; Miguel Martí; Yukiko Muramoto; Takeshi Noda; Kazuo Takayama; Ángel Serrano-Aroca
        International journal of molecular sciences, 01 Sep. 2021
      • Usability of Polydimethylsiloxane-Based Microfluidic Devices in Pharmaceutical Research Using Human Hepatocytes.
        Sayaka Deguchi; Masahiro Tsuda; Kaori Kosugi; Ayaka Sakamoto; Natsumi Mimura; Ryosuke Negoro; Emi Sano; Takuro Nobe; Kazuya Maeda; Hiroyuki Kusuhara; Hiroyuki Mizuguchi; Fumiyoshi Yamashita; Yu-Suke Torisawa; Kazuo Takayama
        ACS biomaterials science & engineering, 09 Aug. 2021
      • In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology.
        Sayaka Deguchi; Tomohiro Shintani; Kazuo Harada; Toru Okamoto; Akinori Takemura; Kazumasa Hirata; Kousei Ito; Kazuo Takayama; Hiroyuki Mizuguchi
        Hepatology communications, Aug. 2021
      • SARS-CoV-2 research using human pluripotent stem cells and organoids.
        Sayaka Deguchi; Ángel Serrano-Aroca; Murtaza M Tambuwala; Bruce D Uhal; Adam M Brufsky; Kazuo Takayama
        Stem cells translational medicine, 24 Jul. 2021
      • The mechanism behind flaring/triggering of autoimmunity disorders associated with COVID-19.
        Elrashdy M Redwan; Mohammed F Alghamdi; Tarek Mohamed Abd El-Aziz; Parise Adadi; Alaa A A Aljabali; Diksha Attrish; Gajendra Kumar Azad; Wagner Baetas-da-Cruz; Debmalya Barh; Nicolas G Bazan; Adam M Brufsky; Gaurav Chauhan; S K Sarif Hassan; Ramesh Kandimalla; Amos Lal; Kenneth Lundstrom; Yogendra Kumar Mishra; Pabitra Pal Choudhury; Giorgio Palù; Pritam K Panda; Damiano Pizzol; Nima Rezaei; Ángel Serrano-Aroca; Samendra P Sherchan; Murat Seyran; Kazuo Takayama; Murtaza M Tambuwala; Bruce D Uhal; Vladimir N Uversky
        Autoimmunity reviews, 16 Jul. 2021
      • Targeting LIN28: a new hope in prostate cancer theranostics.
        Garima Shrivastava; Alaa Aa Aljabali; Seyed Hossein Shahcheraghi; Marzieh Lotfi; Madhur D Shastri; Shakti D Shukla; Dinesh K Chellappan; Niraj Kumar Jha; Krishnan Anand; Harish Dureja; Ritesh M Pabari; Vijay Mishra; Abdulmajeed G Almutary; Abdullah M Alnuqaydan; Nitin Charbe; Parteek Prasher; Poonam Negi; Rohit Goyal; Kamal Dua; Gaurav Gupta; Ángel Serrano-Aroca; Bojlul Bahar; Debmalya Barh; Pritam Kumar Panda; Kazuo Takayama; Kenneth Lundstrom; Paul McCarron; Hamid Bakshi; Murtaza M Tambuwala
        Future oncology (London, England), 15 Jul. 2021
      • COVID-19 Vaccines and Thrombosis-Roadblock or Dead-End Street?
        Kenneth Lundstrom; Debmalya Barh; Bruce D Uhal; Kazuo Takayama; Alaa A A Aljabali; Tarek Mohamed Abd El-Aziz; Amos Lal; Elrashdy M Redwan; Parise Adadi; Gaurav Chauhan; Samendra P Sherchan; Gajendra Kumar Azad; Nima Rezaei; Ángel Serrano-Aroca; Nicolas G Bazan; Sk Sarif Hassan; Pritam Kumar Panda; Pabitra Pal Choudhury; Damiano Pizzol; Ramesh Kandimalla; Wagner Baetas-da-Cruz; Yogendra Kumar Mishra; Giorgio Palu; Adam M Brufsky; Murtaza M Tambuwala; Vladimir N Uversky
        Biomolecules, 13 Jul. 2021
      • Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system.
        Moe Ichikawa; Hiroki Akamine; Michika Murata; Sumito Ito; Kazuo Takayama; Hiroyuki Mizuguchi
        Scientific reports, 03 Jun. 2021
      • A unique view of SARS-CoV-2 through the lens of ORF8 protein.
        Sk Sarif Hassan; Alaa A A Aljabali; Pritam Kumar Panda; Shinjini Ghosh; Diksha Attrish; Pabitra Pal Choudhury; Murat Seyran; Damiano Pizzol; Parise Adadi; Tarek Mohamed Abd El-Aziz; Antonio Soares; Ramesh Kandimalla; Kenneth Lundstrom; Amos Lal; Gajendra Kumar Azad; Vladimir N Uversky; Samendra P Sherchan; Wagner Baetas-da-Cruz; Bruce D Uhal; Nima Rezaei; Gaurav Chauhan; Debmalya Barh; Elrashdy M Redwan; Guy W Dayhoff 2nd; Nicolas G Bazan; Ángel Serrano-Aroca; Amr El-Demerdash; Yogendra K Mishra; Giorgio Palu; Kazuo Takayama; Adam M Brufsky; Murtaza M Tambuwala
        Computers in biology and medicine, Jun. 2021
      • Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial-Resistant Era.
        Ángel Serrano-Aroca; Kazuo Takayama; Alberto Tuñón-Molina; Murat Seyran; Sk Sarif Hassan; Pabitra Pal Choudhury; Vladimir N Uversky; Kenneth Lundstrom; Parise Adadi; Giorgio Palù; Alaa A A Aljabali; Gaurav Chauhan; Ramesh Kandimalla; Murtaza M Tambuwala; Amos Lal; Tarek Mohamed Abd El-Aziz; Samendra Sherchan; Debmalya Barh; Elrashdy M Redwan; Nicolas G Bazan; Yogendra Kumar Mishra; Bruce D Uhal; Adam Brufsky
        ACS nano, 25 May 2021
      • Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells.
        Emi Sano; Sayaka Deguchi; Ayaka Sakamoto; Natsumi Mimura; Ai Hirabayashi; Yukiko Muramoto; Takeshi Noda; Takuya Yamamoto; Kazuo Takayama
        iScience, 21 May 2021
      • Overview of key molecular and pharmacological targets for diabetes and associated diseases.
        Seyed Hossein Shahcheraghi; Alaa A A Aljabali; Mazhar S Al Zoubi; Vijay Mishra; Nitin B Charbe; Yusuf A Haggag; Garima Shrivastava; Abdulmajeed G Almutary; Abdullah M Alnuqaydan; Debmalya Barh; Kamal Dua; Dinesh K Chellappan; Gaurav Gupta; Marzieh Lotfi; Ángel Serrano-Aroca; Bojlul Bahar; Yogendra Kumar Mishra; Kazuo Takayama; Pritam Kumar Panda; Hamid A Bakshi; Murtaza M Tambuwala
        Life sciences, 18 May 2021
      • Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2.
        Sk Sarif Hassan; Diksha Attrish; Shinjini Ghosh; Pabitra Pal Choudhury; Vladimir N Uversky; Alaa A A Aljabali; Kenneth Lundstrom; Bruce D Uhal; Nima Rezaei; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza M Tambuwala; Gajendra Kumar Azad; Samendra P Sherchan; Wagner Baetas-da-Cruz; Amos Lal; Giorgio Palù; Kazuo Takayama; Ángel Serrano-Aroca; Debmalya Barh; Adam M Brufsky
        International journal of biological macromolecules, 16 Apr. 2021
      • Asymmetric profiles of infection and innate immunological responses in human iPS cell-derived small intestinal epithelial-like cell monolayers following infection with mammalian reovirus.
        Chieko Inoue; Ryosuke Negoro; Kazuo Takayama; Hiroyuki Mizuguchi; Fuminori Sakurai
        Virus research, 15 Apr. 2021
      • Vinblastine treatment decreases the undifferentiated cell contamination of human iPSC-derived intestinal epithelial-like cells.
        Moe Ichikawa; Ryosuke Negoro; Kanae Kawai; Tomoki Yamashita; Kazuo Takayama; Hiroyuki Mizuguchi
        Molecular therapy. Methods & clinical development, 12 Mar. 2021
      • In Vivo Gene Expression Profile of Human Intestinal Epithelial Cells: From the Viewpoint of Drug Metabolism and Pharmacokinetics.
        Kazuo Takayama; Kohei Ito; Akiko Matsui; Tomoki Yamashita; Kentaro Kawakami; Daisuke Hirayama; Wataru Kishimoto; Hiroshi Nakase; Hiroyuki Mizuguchi
        Drug metabolism and disposition: the biological fate of chemicals, Mar. 2021
      • Protective Face Mask Filter Capable of Inactivating SARS-CoV-2, and Methicillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis.
        Miguel Martí; Alberto Tuñón-Molina; Finn Lillelund Aachmann; Yukiko Muramoto; Takeshi Noda; Kazuo Takayama; Ángel Serrano-Aroca
        Polymers, 08 Jan. 2021
      • Generation of Hepatocytes from Human ES/iPS Cells for Regenerative Medicine
        Tomoki Yamashita; Kazuo Takayama; Hiroyuki Mizuguchi
        Cell-Inspired Materials and Engineering, 2021
      • Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features.
        Sk Sarif Hassan; Shinjini Ghosh; Diksha Attrish; Pabitra Pal Choudhury; Alaa A A Aljabali; Bruce D Uhal; Kenneth Lundstrom; Nima Rezaei; Vladimir N Uversky; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza M Tambuwala; Gajendra Kumar Azad; Samendra P Sherchan; Wagner Baetas-da-Cruz; Kazuo Takayama; Ángel Serrano-Aroca; Gaurav Chauhan; Giorgio Palu; Adam M Brufsky
        Molecules (Basel, Switzerland), 13 Dec. 2020
      • Introductions to the Community: Early-Career Researchers in the Time of COVID-19.
        Kazuo Takayama; Lesley N Weaver; Edroaldo Lummertz da Rocha; Valentina Lo Sardo; Helmuth Gehart; Ly P Vu
        Cell stem cell, 03 Dec. 2020
      • The structural basis of accelerated host cell entry by SARS-CoV-2†.
        Murat Seyran; Kazuo Takayama; Vladimir N Uversky; Kenneth Lundstrom; Giorgio Palù; Samendra P Sherchan; Diksha Attrish; Nima Rezaei; Alaa A A Aljabali; Shinjini Ghosh; Damiano Pizzol; Gaurav Chauhan; Parise Adadi; Tarek Mohamed Abd El-Aziz; Antonio G Soares; Ramesh Kandimalla; Murtaza Tambuwala; Sk Sarif Hassan; Gajendra Kumar Azad; Pabitra Pal Choudhury; Wagner Baetas-da-Cruz; Ángel Serrano-Aroca; Adam M Brufsky; Bruce D Uhal
        The FEBS journal, 02 Dec. 2020
      • Photoactivatable oncolytic adenovirus for optogenetic cancer therapy.
        Yasuko Hagihara; Ayaka Sakamoto; Takashi Tokuda; Tomoki Yamashita; Sena Ikemoto; Ayaka Kimura; Makito Haruta; Kiyotaka Sasagawa; Jun Ohta; Kazuo Takayama; Hiroyuki Mizuguchi
        Cell death & disease, 23 Jul. 2020
      • Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies.
        Kanae Kawai; Ryosuke Negoro; Moe Ichikawa; Tomoki Yamashita; Sayaka Deguchi; Kazuo Harada; Kazumasa Hirata; Kazuo Takayama; Hiroyuki Mizuguchi
        Molecular therapy. Methods & clinical development, 12 Jun. 2020, Peer-reviewed
      • In Vitro and Animal Models for SARS-CoV-2 research.
        Kazuo Takayama
        Trends in pharmacological sciences, 30 May 2020, Peer-reviewed
      • Generation of human bronchial organoids for SARS-CoV-2 research
        Tatsuya Suzuki; Yumi Itoh; Yusuke Sakai; Akatsuki Saito; Daisuke Okuzaki; Daisuke Motooka; Shohei Minami; Takeshi Kobayashi; Takuya Yamamoto; Toru Okamoto; Kazuo Takayama
        26 May 2020
      • Tolloid-Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling.
        Ayumi Kiso; Yukiko Toba; Susumu Tsutsumi; Sayaka Deguchi; Keisuke Igai; Saki Koshino; Yasuhito Tanaka; Kazuo Takayama; Hiroyuki Mizuguchi
        Hepatology communications, Feb. 2020, Peer-reviewed
      • Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance.
        Yukiko Toba; Sayaka Deguchi; Natsumi Mimura; Ayaka Sakamoto; Kazuo Harada; Kazumasa Hirata; Kazuo Takayama; Hiroyuki Mizuguchi
        PloS one, 2020, Peer-reviewed
      • Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells.
        Sayaka Deguchi; Tomoki Yamashita; Keisuke Igai; Kazuo Harada; Yukiko Toba; Kazumasa Hirata; Kazuo Takayama; Hiroyuki Mizuguchi
        Drug metabolism and disposition: the biological fate of chemicals, Jun. 2019, Peer-reviewed
      • FGF signal is not required for hepatoblast differentiation of human iPS cells.
        Yukiko Toba; Ayumi Kiso; Souichiro Nakamae; Fuminori Sakurai; Kazuo Takayama; Hiroyuki Mizuguchi
        Scientific reports, 06 Mar. 2019, Peer-reviewed
      • Pharmaceutical Research for Inherited Metabolic Disorders of the Liver Using Human Induced Pluripotent Stem Cell and Genome Editing Technologies.
        Tomoki Yamashita; Kazuo Takayama; Mika Hori; Mariko Harada-Shiba; Hiroyuki Mizuguchi
        Biological & pharmaceutical bulletin, 2019, Peer-reviewed
      • Generation of Human iPSC-Derived Intestinal Epithelial Cell Monolayers by CDX2 Transduction.
        Kazuo Takayama; Ryosuke Negoro; Tomoki Yamashita; Kanae Kawai; Moe Ichikawa; Takanori Mori; Noriyuki Nakatsu; Kazuo Harada; Sumito Ito; Hiroshi Yamada; Yoshiyuki Yamaura; Kazumasa Hirata; Seiichi Ishida; Hiroyuki Mizuguchi
        Cellular and molecular gastroenterology and hepatology, 2019, Peer-reviewed
      • [Pharmaceutical Research on Liver Diseases Using iPS Cell and Genome Editing Technologies].
        Kazuo Takayama
        Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2019, Peer-reviewed
      • Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies.
        Ryosuke Negoro; Kazuo Takayama; Kanae Kawai; Kazuo Harada; Fuminori Sakurai; Kazumasa Hirata; Hiroyuki Mizuguchi
        Stem cell reports, 11 Dec. 2018, Peer-reviewed
      • Optimal human iPS cell culture method for efficient hepatic differentiation.
        Matoba N; Yamashita T; Takayama K; Sakurai F; Mizuguchi H
        Differentiation; research in biological diversity, Sep. 2018, Peer-reviewed
      • Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research.
        Kazuo Takayama; Yasuko Hagihara; Yukiko Toba; Kiyotoshi Sekiguchi; Fuminori Sakurai; Hiroyuki Mizuguchi
        Biomaterials, Apr. 2018, Peer-reviewed
      • Nanaomycin A Treatment Promotes Hepatoblast Differentiation from Human iPS Cells.
        Souichiro Nakamae; Yukiko Toba; Kazuo Takayama; Fuminori Sakurai; Hiroyuki Mizuguchi
        Stem cells and development, 15 Mar. 2018, Peer-reviewed
      • Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells.
        Tomoki Yamashita; Kazuo Takayama; Fuminori Sakurai; Hiroyuki Mizuguchi
        Biochemical and biophysical research communications, 19 Feb. 2018, Peer-reviewed
      • Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy.
        Kazuo Takayama; Hiroyuki Mizuguchi
        ACS chemical biology, 16 Feb. 2018, Peer-reviewed
      • Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B.
        Ryota Okamoto; Kazuo Takayama; Naoki Akita; Yasuhito Nagamoto; Daiki Hosokawa; Shunsuke Iizuka; Fuminori Sakurai; Hiroshi Suemizu; Kazuo Ohashi; Hiroyuki Mizuguchi
        Cell transplantation, Feb. 2018, Peer-reviewed
      • Generation of safe and therapeutically effective human induced pluripotent stem cell-derived hepatocyte-like cells for regenerative medicine.
        Kazuo Takayama; Naoki Akita; Natsumi Mimura; Rina Akahira; Yukimasa Taniguchi; Makoto Ikeda; Fuminori Sakurai; Osamu Ohara; Tomohiro Morio; Kiyotoshi Sekiguchi; Hiroyuki Mizuguchi
        Hepatology communications, Dec. 2017, Peer-reviewed
      • y Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction
        Daiki Nakamori; Hiroki Akamine; Kazuo Takayama; Fuminori Sakurai; Hiroyuki Mizuguchi
        SCIENTIFIC REPORTS, Nov. 2017, Peer-reviewed
      • Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells
        Fuminori Sakurai; Takemaru Kunito; Kazuo Takayama; Rina Hashimoto; Masashi Tachibana; Naoya Sakamoto; Takaji Wakita; Hiroyuki Mizuguchi
        VIRUS RESEARCH, Oct. 2017, Peer-reviewed
      • Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation from Human Induced Pluripotent Stem Cells
        Morifumi Hanawa; Kazuo Takayama; Fuminori Sakurai; Masashi Tachibana; Hiroyuki Mizuguchi
        STEM CELL REVIEWS AND REPORTS, Aug. 2017, Peer-reviewed
      • Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling
        Seiji Mitani; Kazuo Takayama; Yasuhito Nagamoto; Kazuo Imagawa; Fuminori Sakurai; Masashi Tachibana; Ryo Sumazaki; Hiroyuki Mizuguchi
        MOLECULAR THERAPY, Jun. 2017, Peer-reviewed
      • Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system
        Kazuo Takayama; Keisuke Igai; Yasuko Hagihara; Rina Hashimoto; Morifumi Hanawa; Tetsushi Sakuma; Masashi Tachibana; Fuminori Sakurai; Takashi Yamamoto; Hiroyuki Mizuguchi
        NUCLEIC ACIDS RESEARCH, May 2017, Peer-reviewed
      • Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection
        Fuminori Sakurai; Seiji Mitani; Tatsuro Yamamoto; Kazuo Takayama; Masashi Tachibana; Koichi Watashi; Takaji Wakita; Sayuki Iijima; Yasuhito Tanaka; Hiroyuki Mizuguchi
        SCIENTIFIC REPORTS, Apr. 2017, Peer-reviewed
      • Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions
        Takayuki Fukuda; Kazuo Takayama; Mitsuhi Hirata; Yu-Jung Liu; Kana Yanagihara; Mika Suga; Hiroyuki Mizuguchi; Miho K. Furue
        EXPERIMENTAL CELL RESEARCH, Mar. 2017, Peer-reviewed
      • Inhibition of CRISPR/Cas9-Mediated Genome Engineering by a Type I Interferon-Induced Reduction in Guide RNA Expression
        Mitsuhiro Machitani; Fuminori Sakurai; Keisaku Wakabayashi; Kosuke Nakatani; Kazuo Takayama; Masashi Tachibana; Hiroyuki Mizuguhi
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, Mar. 2017, Peer-reviewed
      • Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells
        Kazuo Imagawa; Kazuo Takayama; Shigemi Isoyama; Ken Tanikawa; Masato Shinkai; Kazuo Harada; Masashi Tachibana; Fuminori Sakurai; Emiko Noguchi; Kazumasa Hirata; Masayoshi Kage; Kenji Kawabata; Ryo Sumazaki; Hiroyuki Mizuguchi
        Scientific Reports, Feb. 2017, Peer-reviewed
      • Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening
        Kazuo Takayama; Hiroyuki Mizuguchi
        DRUG METABOLISM AND PHARMACOKINETICS, Feb. 2017, Peer-reviewed
      • Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells
        Kana Yanagihara; Yujung Liu; Kei Kanie; Kazuo Takayama; Minako Kokunugi; Mitsuhi Hirata; Takayuki Fukuda; Mika Suga; Hiroki Nikawa; Hiroyuki Mizuguchi; Ryuji Kato; Miho K. Furue
        STEM CELLS AND DEVELOPMENT, Dec. 2016, Peer-reviewed
      • Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure
        Yasuhito Nagamoto; Kazuo Takayama; Kazuo Ohashi; Ryota Okamoto; Fuminori Sakurai; Masashi Tachibana; Kenji Kawabata; Hiroyuki Mizuguchi
        JOURNAL OF HEPATOLOGY, May 2016, Peer-reviewed
      • Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells
        Kazuo Takayama; Seiji Mitani; Yasuhito Nagamoto; Fuminori Sakurai; Masashi Tachibana; Yukimasa Taniguchi; Kiyotoshi Sekiguchi; Hiroyuki Mizuguchi
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2016, Peer-reviewed
      • Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cellst
        Ryosuke Negoro; Kazuo Takayama; Yasuhito Nagamoto; Fuminori Sakurai; Masashi Tachibana; Hiroyuki Mizuguchi
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2016, Peer-reviewed
      • Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBP alpha, and PROX1 transduction
        Daiki Nakamori; Kazuo Takayama; Yasuhito Nagamoto; Seiji Mitani; Fuminori Sakurai; Masashi Tachibana; Hiroyuki Mizuguchi
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2016, Peer-reviewed
      • Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine
        Tatsuya Ozawa; Kazuo Takayama; Ryota Okamoto; Ryosuke Negoro; Fuminori Sakurai; Masashi Tachibana; Kenji Kawabata; Hiroyuki Mizuguchi
        SCIENTIFIC REPORTS, Nov. 2015, Peer-reviewed
      • Establishment of a Method of Hepatocyte Differentiation from Human Pluripotent Stem Cells for Innovative Drug Development
        Kazuo Takayama
        YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Oct. 2015, Peer-reviewed
      • Generation of Brain Microvascular Endothelial-Like Cells from Human Induced Pluripotent Stem Cells by Co-Culture with C6 Glioma Cells
        Haruka Minami; Katsuhisa Tashiro; Atsumasa Okada; Nobue Hirata; Tomoko Yamaguchi; Kazuo Takayama; Hiroyuki Mizuguchi; Kenji Kawabata
        PLOS ONE, Jun. 2015, Peer-reviewed
      • Expression of Coxsackievirus and Adenovirus Receptor Separates Hematopoietic and Cardiac Progenitor Cells in Fetal Liver Kinase 1-Expressing Mesoderm
        Katsuhisa Tashiro; Nobue Hirata; Atsumasa Okada; Tomoko Yamaguchi; Kazuo Takayama; Hiroyuki Mizuguchi; Kenji Kawabata
        STEM CELLS TRANSLATIONAL MEDICINE, May 2015, Peer-reviewed
      • Expression of Coxsackievirus and Adenovirus Receptor Separates Hematopoietic and Cardiac Progenitor Cells in Fetal Liver Kinase 1-Expressing Mesoderm
        Katsuhisa Tashiro; Nobue Hirata; Atsumasa Okada; Tomoko Yamaguchi; Kazuo Takayama; Hiroyuki Mizuguchi; Kenji Kawabata
        STEM CELLS TRANSLATIONAL MEDICINE, May 2015, Peer-reviewed
      • Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene
        Yasuhito Nagamoto; Kazuo Takayama; Katsuhisa Tashiro; Chise Tateno; Fuminori Sakurai; Masashi Tachibana; Kenji Kawabata; Kazuo Ikeda; Yasuhito Tanaka; Hiroyuki Mizuguchi
        CELL TRANSPLANTATION, 2015, Peer-reviewed
      • Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene
        Yasuhito Nagamoto; Kazuo Takayama; Katsuhisa Tashiro; Chise Tateno; Fuminori Sakurai; Masashi Tachibana; Kenji Kawabata; Kazuo Ikeda; Yasuhito Tanaka; Hiroyuki Mizuguchi
        CELL TRANSPLANTATION, 2015, Peer-reviewed
      • Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes
        Kazuo Takayama; Yuta Morisaki; Shuichi Kuno; Yasuhito Nagamoto; Kazuo Harada; Norihisa Furukawa; Manami Ohtaka; Ken Nishimura; Kazuo Imagawa; Fuminori Sakurai; Masashi Tachibana; Ryo Sumazaki; Emiko Noguchi; Mahito Nakanishi; Kazumasa Hirata; Kenji Kawabata; Hiroyuki Mizuguchi
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 2014, Peer-reviewed
      • HHEX Promotes Hepatic-Lineage Specification through the Negative Regulation of Eomesodermin
        Hitoshi Watanabe; Kazuo Takayama; Mitsuru Inamura; Masashi Tachibana; Natsumi Mimura; Kazufumi Katayama; Katsuhisa Tashiro; Yasuhito Nagamoto; Fuminori Sakurai; Kenji Kawabata; Miho Kusuda Furue; Hiroyuki Mizuguchi
        PLOS ONE, Mar. 2014, Peer-reviewed
      • CCAAT/enhancer binding protein-mediated regulation of TGF beta receptor 2 expression determines the hepatoblast fate decision
        Kazuo Takayama; Kenji Kawabata; Yasuhito Nagamoto; Mitsuru Inamura; Kazuo Ohashi; Hiroko Okuno; Tomoko Yamaguchi; Katsuhisa Tashiro; Fuminori Sakurai; Takao Hayakawa; Teruo Okano; Miho Kusada Furue; Hiroyuki Mizuguchi
        DEVELOPMENT, Jan. 2014, Peer-reviewed
      • CCAAT/enhancer binding protein-mediated regulation of TGF beta receptor 2 expression determines the hepatoblast fate decision
        Kazuo Takayama; Kenji Kawabata; Yasuhito Nagamoto; Mitsuru Inamura; Kazuo Ohashi; Hiroko Okuno; Tomoko Yamaguchi; Katsuhisa Tashiro; Fuminori Sakurai; Takao Hayakawa; Teruo Okano; Miho Kusada Furue; Hiroyuki Mizuguchi
        DEVELOPMENT, Jan. 2014, Peer-reviewed
      • Long-Term Self-Renewal of Human ES/iPS-Derived Hepatoblast-like Cells on Human Laminin 111-Coated Dishes
        Kazuo Takayama; Yasuhito Nagamoto; Natsumi Mimura; Katsuhisa Tashiro; Fuminori Sakurai; Masashi Tachibana; Takao Hayakawa; Kenji Kawabata; Hiroyuki Mizuguchi
        STEM CELL REPORTS, Oct. 2013, Peer-reviewed
      • 3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing.
        Kazuo Takayama; Kenji Kawabata; Yasuhito Nagamoto; Keisuke Kishimoto; Katsuhisa Tashiro; Fuminori Sakurai; Masashi Tachibana; Katsuhiro Kanda; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi
        Biomaterials, Feb. 2013, Peer-reviewed
      • Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1 alpha transduction
        Kazuo Takayama; Mitsuru Inamura; Kenji Kawabata; Michiko Sugawara; Kiyomi Kikuchi; Maiko Higuchi; Yasuhito Nagamoto; Hitoshi Watanabe; Katsuhisa Tashiro; Fuminori Sakurai; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi
        JOURNAL OF HEPATOLOGY, Sep. 2012, Peer-reviewed
      • The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets
        Yasuhito Nagamoto; Katsuhisa Tashiro; Kazuo Takayama; Kazuo Ohashi; Kenji Kawabata; Fuminori Sakurai; Masashi Tachibana; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi
        BIOMATERIALS, Jun. 2012, Peer-reviewed
      • Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4 alpha Transduction
        Kazuo Takayama; Mitsuru Inamura; Kenji Kawabata; Kazufumi Katayama; Maiko Higuchi; Katsuhisa Tashiro; Aki Nonaka; Fuminori Sakurai; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi
        MOLECULAR THERAPY, Jan. 2012, Peer-reviewed
      • Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4 alpha Transduction
        Kazuo Takayama; Mitsuru Inamura; Kenji Kawabata; Kazufumi Katayama; Maiko Higuchi; Katsuhisa Tashiro; Aki Nonaka; Fuminori Sakurai; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi
        MOLECULAR THERAPY, Jan. 2012, Peer-reviewed
      • Endodermal and Hepatic Differentiation from Human Embryonic Stem Cells and Human Induced Pluripotent Stem Cells.
        Kawabata K; Takayama K; Nagamoto Y; Saldon M.S; Higuchi M; Mizuguchi H
        J Stem Cell Res Ther., 2012, Peer-reviewed
      • Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection
        Takeshi Yoshida; Kazuo Takayama; Masuo Kondoh; Fuminori Sakurai; Hideki Tani; Naoya Sakamoto; Yoshiharu Matsuura; Hiroyuki Mizuguchi; Kiyohito Yagi
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2011, Peer-reviewed
      • Efficient and Directive Generation of Two Distinct Endoderm Lineages from Human ESCs and iPSCs by Differentiation Stage-Specific SOX17 Transduction
        Kazuo Takayama; Mitsuru Inamura; Kenji Kawabata; Katsuhisa Tashiro; Kazufumi Katayama; Fuminori Sakurai; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi
        PLOS ONE, Jul. 2011, Peer-reviewed
      • Efficient Generation of Hepatoblasts From Human ES Cells and iPS Cells by Transient Overexpression of Homeobox Gene HEX
        Mitsuru Inamura; Kenji Kawabata; Kazuo Takayama; Katsuhisa Tashiro; Fuminori Sakurai; Kazufumi Katayama; Masashi Toyoda; Hidenori Akutsu; Yoshitaka Miyagawa; Hajime Okita; Nobutaka Kiyokawa; Akihiro Umezawa; Takao Hayakawa; Miho K. Furue; Hiroyuki Mizuguchi
        MOLECULAR THERAPY, Feb. 2011, Peer-reviewed
      • Adenovirus Vector-Mediated Efficient Transduction into Human Embryonic and Induced Pluripotent Stem Cells
        Katsuhisa Tashiro; Kenji Kawabata; Mitsuru Inamura; Kazuo Takayama; Norihisa Furukawa; Fuminori Sakurai; Kazufumi Katayama; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi
        CELLULAR REPROGRAMMING, Oct. 2010, Peer-reviewed
      • The importance of accessory protein variants in the pathogenicity of SARS-CoV-2.
        Sk Sarif Hassan; Pabitra Pal Choudhury; Guy W Dayhoff 2nd; Alaa A A Aljabali; Bruce D Uhal; Kenneth Lundstrom; Nima Rezaei; Damiano Pizzol; Parise Adadi; Amos Lal; Antonio Soares; Tarek Mohamed Abd El-Aziz; Adam M Brufsky; Gajendra Kumar Azad; Samendra P Sherchan; Wagner Baetas-da-Cruz; Kazuo Takayama; Ãngel Serrano-Aroca; Gaurav Chauhan; Giorgio Palu; Yogendra Kumar Mishra; Debmalya Barh; Raner Jośe Santana Silva; Bruno Silva Andrade; Vasco Azevedo; Aristóteles Góes-Neto; Nicolas G Bazan; Elrashdy M Redwan; Murtaza Tambuwala; Vladimir N Uversky
        Archives of biochemistry and biophysics, 15 Mar. 2022
      • Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening.
        Tomohisa Tanaka; Akatsuki Saito; Tatsuya Suzuki; Yoichi Miyamoto; Kazuo Takayama; Toru Okamoto; Kohji Moriishi
        Antiviral research, 07 Mar. 2022
      • Gene Therapy for Neuropsychiatric Disorders: Potential Targets and Tools.
        Seyed Hossein Shahcheraghi; Jamshid Ayatollahi; Marzieh Lotfi; Alaa A A Aljabali; Mazhar S Al-Zoubi; Pritam Kumar Panda; Vijay Mishra; Saurabh Satija; Nitin B Charbe; Ángel Serrano-Aroca; Bojlul Bahar; Kazuo Takayama; Rohit Goyal; Amit Bhatia; Abdulmajeed G Almutary; Abdullah M Alnuqaydan; Yachana Mishra; Poonam Negi; Aaron Courtney; Paul A McCarron; Hamid A Bakshi; Murtaza M Tambuwala
        CNS & neurological disorders drug targets, 04 Mar. 2022
      • Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function.
        Sk Sarif Hassan; Kenneth Lundstrom; Ángel Serrano-Aroca; Parise Adadi; Alaa A A Aljabali; Elrashdy M Redwan; Amos Lal; Ramesh Kandimalla; Tarek Mohamed Abd El-Aziz; Pabitra Pal Choudhury; Gajendra Kumar Azad; Samendra P Sherchan; Gaurav Chauhan; Murtaza Tambuwala; Kazuo Takayama; Debmalya Barh; Giorgio Palu; Pallab Basu; Vladimir N Uversky
        International journal of biological macromolecules, 01 Jan. 2022
      • Non-Woven Infection Prevention Fabrics Coated with Biobased Cranberry Extracts Inactivate Enveloped Viruses Such as SARS-CoV-2 and Multidrug-Resistant Bacteria.
        Kazuo Takayama; Alberto Tuñón-Molina; Alba Cano-Vicent; Yukiko Muramoto; Takeshi Noda; José Luis Aparicio-Collado; Roser Sabater I Serra; Miguel Martí; Ángel Serrano-Aroca
        International journal of molecular sciences, 24 Nov. 2021

      Misc.

      • Generation of human iPS cell-derived enterocytes for drug discovery
        高山 和雄; 水口 裕之
        バイオサイエンスとインダストリー, 2016
      • Current Status of Hepatic Differentiation from Human iPS cells and Application of Drug Development
        水口 裕之; 高山 和雄; 長基 康人
        医薬品医療機器レギュラトリーサイエンス, 2012
      • Establishment of MDR1-knockout human induced pluripotent stem cell line.
        Ryosuke Negoro; Kanae Kawai; Moe Ichikawa; Sayaka Deguchi; Kazuo Takayama; Hiroyuki Mizuguchi
        Drug metabolism and pharmacokinetics, 10 Feb. 2020
      • Generation of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells for Cellular Medicine.
        Sayaka Deguchi; Kazuo Takayama; Hiroyuki Mizuguchi
        Biological & pharmaceutical bulletin, 2020, Peer-reviewed
      • 再生医療への応用を見据えた臨床グレートのヒトiPS細胞由来肝細胞の作製
        高山 和雄; 萩原 康子; 関口 清俊; 森尾 友宏; 小原 收; 立花 雅史; 櫻井 文教; 水口 裕之
        日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, Dec. 2015
      • Human iPSC-derived hepatocyte-like cells generated from patients with bile salt export pump deficiency recapitulate the phenotype of progressive familial intrahepatic cholestasis type 2
        Kazuo Imagawa; Kazuo Takayama; Shigemi Isoyama; Ken Tanikawa; Masato Shinkai; Masayoshi Kage; Kenji Kawabata; Ryo Sumazaki; Hiroyuki Mizuguchi
        HEPATOLOGY, Oct. 2015
      • Efficient Generation of Hepatocyte-like Cells from Human ES/iPS Cells for Drug Toxicity Screening
        高山 和雄; 川端 健二; 水口 裕之
        最新医学, Jan. 2013
      • Evaluation of Drug Toxicity by Using Hepatocytes Derived from Human iPS Cells
        川端 健二; 高山 和雄; 水口 裕之
        Bio industry, Jan. 2013
      • Human iPS-derived hepatocyte-like cells as a model for hepatitis C virus infection
        Seiji Yamane; Takeshi Yoshida; Kazuo Takayama; Masuo Kondoh; Fuminori Sakurai; Hiroyuki Mizuguchi; Kiyohito Yagi
        FASEB JOURNAL, Apr. 2012

      Industrial Property Rights

      • 特開2017-018026, 特願2015-137995, 多能性幹細胞の遺伝子ターゲティング方法
        水口 裕之; 高山 和雄
      • 特許第5970245号, 特開2013-252081, 特願2012-128872, 幹細胞から肝細胞への分化誘導方法
        水口 裕之; 川端 健二; 高山 和雄
      • 特開2016-010379, 特願2014-134701, 薬物評価用細胞及び薬物評価方法
        水口 裕之; 高山 和雄
      • 特開2013-252081, 特願2012-128872, 幹細胞から肝細胞への分化誘導方法
        水口 裕之; 川端 健二; 高山 和雄

      External funds: Kakenhi

      • Elucidation of the role of basal stem cells in respiratory diseases
        Grant-in-Aid for Scientific Research (B)
        Basic Section 90110:Biomedical engineering-related
        Kyoto University
        高山 和雄
        From 01 Apr. 2021, To 31 Mar. 2024, Granted
        基底細胞;呼吸器感染症;気道;気管支;iPS細胞;SARS-CoV-2
      • Elucidation of mechanism of chronic intestinal inflammation at single-cell level using optogenetic technique
        Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
        Osaka University
        高山 和雄
        From 01 Apr. 2018, To 31 Mar. 2020, Project Closed
        光操作;腸管上皮細胞;慢性炎症;腸炎;光遺伝学;ゲノム編集;1細胞;大腸がん;幹細胞
      • Generation of zone-specific hepatocyte for study of liver injury and diseases
        Grant-in-Aid for Challenging Research (Exploratory)
        Osaka University
        Kazuo Takayama
        From 30 Jun. 2017, To 31 Mar. 2019, Project Closed
        肝細胞;毒性;薬物代謝;zonation;ヒトiPS細胞;ヒトES細胞;肝障害;胆管上皮細胞;創薬;異物代謝;分化誘導;肝臓;ヒトES/iPS細胞
      • Generation of CYP3A4-expressing human ES/iPS cell-derived hepatocytes for drug screening
        Grant-in-Aid for Research Activity Start-up
        Osaka University
        Kazuo Takayama
        From 28 Aug. 2015, To 31 Mar. 2017, Project Closed
        肝細胞;ヒトES/iPS細胞;薬物代謝;CYP;肝毒性;創薬試験;CYP3A4;ゲノム編集;薬物代謝酵素;相同組換え

      External funds: others

      • SARS-CoV-2の生活環を再現できるヒト肺モデルの開発と創薬応用 (2020年度分)
        京都発革新的医療技術研究開発助成事業
        From 01 Apr. 2020, To 31 Mar. 2021
        高山 和雄

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