Basic Information

Professional Memberships

• 日本動物実験代替法学会
• 日本ウイルス学会

Academic Degree

• 修士（薬科学）(大阪大学)
• 博士（薬科学）(大阪大学)

Research History

• From Mar. 2020, To Present

  京都大学iPS細胞研究所, 講師
• From Oct. 2016, To Mar. 2020

  さきがけ研究者
• From Feb. 2018, To Feb. 2020

  Osaka University, Graduate School of Pharmaceutical Sciences, 助教
• From Apr. 2015, To Jan. 2018

  Osaka University, Graduate School of Pharmaceutical Sciences, Drug Innovation Center, 特任助教
• From Nov. 2015, To Mar. 2017

  K-CONNEX研究者

Language of Instruction

• Japanese
• English

ID,URL

• ORCID ID

  0000-0002-1132-2457

• J-Global ID

  201601014824797050

• Researcher number

  10759509

researchmap URL

• https://researchmap.jp/kazu0

Research

Research Interests

• ウイルス
• オルガノイド
• 感染症
• organs-on-a-chip
• iPS cells
• pluripotent stem cells
• drug discovery

Research Areas

• Life sciences, Clinical pharmacy

Papers

• Anti-SARS-CoV-2 gapmer antisense oligonucleotides targeting the main protease region of viral RNA.

  Masako Yamasaki; Wakana Saso; Takuya Yamamoto; Masayoshi Sato; Hiroko Takagi; Tetsuya Hasegawa; Yuji Kozakura; Hiroyuki Yokoi; Hirofumi Ohashi; Kana Tsuchimoto; Rina Hashimoto; Shuetsu Fukushi; Akihiko Uda; Masamichi Muramatsu; Kazuo Takayama; Ken Maeda; Yoshimasa Takahashi; Tsuyoshi Nagase; Koichi Watashi

  Antiviral research, 23 Aug. 2024

  
• Refining Hepatocyte Models to Capture the Impact of CYP2D6*10 Utilizing a PITCh System.

  Ryosuke Negoro; Ayu Ouchi; Sayaka Deguchi; Kazuo Takayama; Takuya Fujita

  Biological & pharmaceutical bulletin, 2024

  
• Perfluoropolyether-Based Gut-Liver-on-a-Chip for the Evaluation of First-Pass Metabolism and Oral Bioavailability of Drugs

  Mengyang Wang; Yuko Sasaki; Rena Sakagami; Tomotaka Minamikawa; Masahiro Tsuda; Ryohei Ueno; Sayaka Deguchi; Ryosuke Negoro; Kanako So; Yuriko Higuchi; Ryuji Yokokawa; Kazuo Takayama; Fumiyoshi Yamashita

  ACS Biomaterials Science and Engineering, 2024

  
• Establishment of MDR1-knockout human induced pluripotent stem cell line.

  Negoro R; Kawai K; Ichikawa M; Deguchi S; Takayama K; Mizuguchi H

  Drug metabolism and pharmacokinetics, Feb. 2020

  
• Generation of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells for Cellular Medicine.

  Deguchi S; Takayama K; Mizuguchi H

  Biological & pharmaceutical bulletin, Jan. 2020

  
• 進行性家族性胆汁うっ滞症2型の疾患特異的iPS細胞を用いた研究

  今川 和生; 高山 和雄; 磯山 茂美; 野口 恵美子; 新開 真人; 立花 雅史; 櫻井 文教; 川端 健二; 須磨崎 亮; 水口 裕之

  日本小児科学会雑誌, Feb. 2015

  
• Construction of multilayered small intestine-like tissue by reproducing interstitial flow

  Sayaka Deguchi; Kaori Kosugi; Naoki Takeishi; Yukio Watanabe; Shiho Morimoto; Ryosuke Negoro; Fuki Yokoi; Hiroki Futatsusako; May Nakajima-Koyama; Mio Iwasaki; Takuya Yamamoto; Yoshiya Kawaguchi; Yu-suke Torisawa; Kazuo Takayama

  Cell Stem Cell, Jul. 2024

  
• Endothelial ROBO4 suppresses PTGS2/COX-2 expression and inflammatory diseases.

  Masato Tanaka; Keisuke Shirakura; Yui Takayama; Miki Μatsui; Yukio Watanabe; Takuya Yamamoto; Junya Takahashi; Shota Tanaka; Nobumasa Hino; Takefumi Doi; Masanori Obana; Yasushi Fujio; Kazuo Takayama; Yoshiaki Okada

  Communications biology, 18 May 2024

  
• Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236

  Shigeru Fujita; Arnon Plianchaisuk; Sayaka Deguchi; Hayato Ito; Naganori Nao; Lei Wang; Hesham Nasser; Tomokazu Tamura; Izumi Kimura; Yukie Kashima; Rigel Suzuki; Saori Suzuki; Izumi Kida; Masumi Tsuda; Yoshitaka Oda; Rina Hashimoto; Yukio Watanabe; Keiya Uriu; Daichi Yamasoba; Ziyi Guo; Alfredo A. Hinay; Yusuke Kosugi; Luo Chen; Lin Pan; Yu Kaku; Hin Chu; Flora Donati; Sarah Temmam; Marc Eloit; Yuki Yamamoto; Tetsuharu Nagamoto; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Yutaka Suzuki; Hirofumi Sawa; Keita Mizuma; Jingshu Li; Yume Mimura; Yuma Ohari; Tomoya Tsubo; Zannatul Ferdous; Kenji Shishido; Hiromi Mohri; Miki Iida; Shuhei Tsujino; Naoko Misawa; Kaoru Usui; Wilaiporn Saikruang; Spyridon Lytras; Shusuke Kawakubo; Luca Nishumura; Jarel Elgin Mendoza Tolentino; Wenye Li; Maximilian Stanley Yo; Kio Horinaka; Mai Suganami; Mika Chiba; Ryo Yoshimura; Kyoko Yasuda; Keiko Iida; Adam Patrick Strange; Naomi Ohsumi; Shiho Tanaka; Eiko Ogawa; Kaho Okumura; Tsuki Fukuda; Rina Osujo; Isao Yoshida; So Nakagawa; Akifumi Takaori-Kondo; Kotaro Shirakawa; Kayoko Nagata; Ryosuke Nomura; Yoshihito Horisawa; Yusuke Tashiro; Yugo Kawai; Yoshitaka Nakata; Hiroki Futatsusako; Ayaka Sakamoto; Naoko Yasuhara; Takao Hashiguchi; Tateki Suzuki; Kanako Kimura; Jiei Sasaki; Yukari Nakajima; Hisano Yajima; Takashi Irie; Ryoko Kawabata; Kaori Sasaki-Tabata; Ryo Shimizu; M.S.T. Monira Begum; Michael Jonathan; Yuka Mugita; Sharee Leong; Otowa Takahashi; Kimiko Ichihara; Takamasa Ueno; Chihiro Motozono; Mako Toyoda; Akatsuki Saito; Anon Kosaka; Miki Kawano; Natsumi Matsubara; Tomoko Nishiuchi; Jiri Zahradnik; Prokopios Andrikopoulos; Miguel Padilla-Blanco; Aditi Konar; Jumpei Ito; Terumasa Ikeda; Shinya Tanaka; Keita Matsuno; Takasuke Fukuhara; Kazuo Takayama; Kei Sato

  eBioMedicine, Jun. 2024

  
• Longitudinal analysis of genomic mutations in SARS-CoV-2 isolates from persistent COVID-19 patient.

  Hiroki Futatsusako; Rina Hashimoto; Masaki Yamamoto; Jumpei Ito; Yasufumi Matsumura; Hajime Yoshifuji; Kotaro Shirakawa; Akifumi Takaori-Kondo; Kei Sato; Miki Nagao; Kazuo Takayama

  iScience, 17 May 2024

  
• Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants.

  Atsushi Masui; Rina Hashimoto; Yasufumi Matsumura; Takuya Yamamoto; Miki Nagao; Takeshi Noda; Kazuo Takayama; Shimpei Gotoh

  Stem cell reports, 09 Apr. 2024

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• A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT).

  Kenjiro Hanaoka; Takayuki Ikeno; Shimpei Iwaki; Sayaka Deguchi; Kazuo Takayama; Hiroyuki Mizuguchi; Fumiya Tao; Nobuhiko Kojima; Hisashi Ohno; Eita Sasaki; Toru Komatsu; Tasuku Ueno; Kazuya Maeda; Hiroyuki Kusuhara; Yasuteru Urano

  Science advances, 16 Feb. 2024

  
• Virological characteristics of the SARS-CoV-2 BA.2.86 variant.

  Tomokazu Tamura; Keita Mizuma; Hesham Nasser; Sayaka Deguchi; Miguel Padilla-Blanco; Yoshitaka Oda; Keiya Uriu; Jarel E M Tolentino; Shuhei Tsujino; Rigel Suzuki; Isshu Kojima; Naganori Nao; Ryo Shimizu; Lei Wang; Masumi Tsuda; Michael Jonathan; Yusuke Kosugi; Ziyi Guo; Alfredo A Hinay Jr; Olivia Putri; Yoonjin Kim; Yuri L Tanaka; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Akatsuki Saito; Jumpei Ito; Takashi Irie; Shinya Tanaka; Jiri Zahradnik; Terumasa Ikeda; Kazuo Takayama; Keita Matsuno; Takasuke Fukuhara; Kei Sato

  Cell host & microbe, 14 Feb. 2024

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• Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19.

  Eri Kawakami; Norikazu Saiki; Yosuke Yoneyama; Chiharu Moriya; Mari Maezawa; Shuntaro Kawamura; Akiko Kinebuchi; Tamaki Kono; Masaaki Funata; Ayaka Sakoda; Shigeru Kondo; Takeshi Ebihara; Hisatake Matsumoto; Yuki Togami; Hiroshi Ogura; Fuminori Sugihara; Daisuke Okuzaki; Takashi Kojima; Sayaka Deguchi; Sebastien Vallee; Susan McQuade; Rizwana Islam; Madhusudan Natarajan; Hirohito Ishigaki; Misako Nakayama; Cong Thanh Nguyen; Yoshinori Kitagawa; Yunheng Wu; Kensaku Mori; Takayuki Hishiki; Tomohiko Takasaki; Yasushi Itoh; Kazuo Takayama; Yasunori Nio; Takanori Takebe

  Cell stem cell, 05 Oct. 2023

  
• SARS-CoV-2-induced disruption of a vascular bed in a microphysiological system caused by type-I interferon from bronchial organoids.

  Kazuya Fujimoto; Yoshikazu Kameda; Yuta Nagano; Sayaka Deguchi; Takuya Yamamoto; Rafal P Krol; Peter Gee; Yasufumi Matsumura; Toru Okamoto; Miki Nagao; Kazuo Takayama; Ryuji Yokokawa

  Lab on a chip, 22 Jan. 2024

  
• Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant.

  Tomokazu Tamura; Takashi Irie; Sayaka Deguchi; Hisano Yajima; Masumi Tsuda; Hesham Nasser; Keita Mizuma; Arnon Plianchaisuk; Saori Suzuki; Keiya Uriu; Mst Monira Begum; Ryo Shimizu; Michael Jonathan; Rigel Suzuki; Takashi Kondo; Hayato Ito; Akifumi Kamiyama; Kumiko Yoshimatsu; Maya Shofa; Rina Hashimoto; Yuki Anraku; Kanako Terakado Kimura; Shunsuke Kita; Jiei Sasaki; Kaori Sasaki-Tabata; Katsumi Maenaka; Naganori Nao; Lei Wang; Yoshitaka Oda; Terumasa Ikeda; Akatsuki Saito; Keita Matsuno; Jumpei Ito; Shinya Tanaka; Kei Sato; Takao Hashiguchi; Kazuo Takayama; Takasuke Fukuhara

  Nature communications, 08 Feb. 2024

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• Generation of human bronchial organoids for SARS-CoV-2 research

  Tatsuya Suzuki; Yumi Itoh; Yusuke Sakai; Akatsuki Saito; Daisuke Okuzaki; Daisuke Motooka; Shohei Minami; Takeshi Kobayashi; Takuya Yamamoto; Toru Okamoto; Kazuo Takayama

  26 May 2020, Peer-reviewed

  
• Pluripotent stem cell-based therapies and their path to the clinic.

  Kazuo Takayama; Shinya Yamanaka

  Stem cell reports, 08 Aug. 2023

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• Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5.

  Tomokazu Tamura; Daichi Yamasoba; Yoshitaka Oda; Jumpei Ito; Tomoko Kamasaki; Naganori Nao; Rina Hashimoto; Yoichiro Fujioka; Rigel Suzuki; Lei Wang; Hayato Ito; Yukie Kashima; Izumi Kimura; Mai Kishimoto; Masumi Tsuda; Hirofumi Sawa; Kumiko Yoshimatsu; Yuki Yamamoto; Tetsuharu Nagamoto; Jun Kanamune; Yutaka Suzuki; Yusuke Ohba; Isao Yokota; Keita Matsuno; Kazuo Takayama; Shinya Tanaka; Kei Sato; Takasuke Fukuhara

  Communications biology, 24 Jul. 2023

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• SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

  Shunya Tsuji; Shohei Minami; Rina Hashimoto; Yusuke Konishi; Tatsuya Suzuki; Tamae Kondo; Miwa Sasai; Shiho Torii; Chikako Ono; Shintaro Shichinohe; Shintaro Sato; Masahiro Wakita; Shintaro Okumura; Sosuke Nakano; Tatsuyuki Matsudaira; Tomonori Matsumoto; Shimpei Kawamoto; Masahiro Yamamoto; Tokiko Watanabe; Yoshiharu Matsuura; Kazuo Takayama; Takeshi Kobayashi; Toru Okamoto; Eiji Hara

  Nature Aging, Feb. 2022

  
• Virological characterization of the 2022 outbreak-causing monkeypox virus using human keratinocytes and colon organoids.

  Yukio Watanabe; Izumi Kimura; Rina Hashimoto; Ayaka Sakamoto; Naoko Yasuhara; Takuya Yamamoto; Kei Sato; Kazuo Takayama

  Journal of medical virology, Jun. 2023

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• Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants.

  Tomokazu Tamura; Jumpei Ito; Keiya Uriu; Jiri Zahradnik; Izumi Kida; Yuki Anraku; Hesham Nasser; Maya Shofa; Yoshitaka Oda; Spyros Lytras; Naganori Nao; Yukari Itakura; Sayaka Deguchi; Rigel Suzuki; Lei Wang; Mst Monira Begum; Shunsuke Kita; Hisano Yajima; Jiei Sasaki; Kaori Sasaki-Tabata; Ryo Shimizu; Masumi Tsuda; Yusuke Kosugi; Shigeru Fujita; Lin Pan; Daniel Sauter; Kumiko Yoshimatsu; Saori Suzuki; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Yuki Yamamoto; Tetsuharu Nagamoto; Gideon Schreiber; Katsumi Maenaka; Takao Hashiguchi; Terumasa Ikeda; Takasuke Fukuhara; Akatsuki Saito; Shinya Tanaka; Keita Matsuno; Kazuo Takayama; Kei Sato

  Nature communications, 16 May 2023

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• Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant.

  Jumpei Ito; Rigel Suzuki; Keiya Uriu; Yukari Itakura; Jiri Zahradnik; Kanako Terakado Kimura; Sayaka Deguchi; Lei Wang; Spyros Lytras; Tomokazu Tamura; Izumi Kida; Hesham Nasser; Maya Shofa; Mst Monira Begum; Masumi Tsuda; Yoshitaka Oda; Tateki Suzuki; Jiei Sasaki; Kaori Sasaki-Tabata; Shigeru Fujita; Kumiko Yoshimatsu; Hayato Ito; Naganori Nao; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Yuki Yamamoto; Tetsuharu Nagamoto; Jin Kuramochi; Gideon Schreiber; Akatsuki Saito; Keita Matsuno; Kazuo Takayama; Takao Hashiguchi; Shinya Tanaka; Takasuke Fukuhara; Terumasa Ikeda; Kei Sato

  Nature communications, 11 May 2023

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• Organ-on-a-chip models for elucidating the cellular biology of infectious diseases.

  Fuki Yokoi; Sayaka Deguchi; Kazuo Takayama

  Biochimica et biophysica acta. Molecular cell research, 26 May 2023

  
• Evaluation of Broad Anti-Coronavirus Activity of Autophagy-Related Compounds Using Human Airway Organoids.

  Rina Hashimoto; Tomokazu Tamura; Yukio Watanabe; Ayaka Sakamoto; Naoko Yasuhara; Hayato Ito; Masahiro Nakano; Hiromitsu Fuse; Akira Ohta; Takeshi Noda; Yasufumi Matsumura; Miki Nagao; Takuya Yamamoto; Takasuke Fukuhara; Kazuo Takayama

  Molecular pharmaceutics, 03 Apr. 2023

  
• Elucidation of the liver pathophysiology of COVID-19 patients using liver-on-a-chips.

  Sayaka Deguchi; Kaori Kosugi; Rina Hashimoto; Ayaka Sakamoto; Masaki Yamamoto; Rafal P Krol; Peter Gee; Ryosuke Negoro; Takeshi Noda; Takuya Yamamoto; Yu-Suke Torisawa; Miki Nagao; Kazuo Takayama

  PNAS nexus, Mar. 2023

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• [State-of-the-art in respiratory disease research using respiratory organoids].

  Sayaka Deguchi; Kazuo Takayama

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2023

  
• Design of a chimeric ACE-2/Fc-silent fusion protein with ultrahigh affinity and neutralizing capacity for SARS-CoV-2 variants.

  Neil M Bodie; Rina Hashimoto; David Connolly; Jennifer Chu; Kazuo Takayama; Bruce D Uhal

  Antibody therapeutics, Jan. 2023

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• Non-uniform aspects of the SARS-CoV-2 intraspecies evolution reopen question of its origin.

  Sk Sarif Hassan; Vaishnavi Kodakandla; Elrashdy M Redwan; Kenneth Lundstrom; Pabitra Pal Choudhury; Ángel Serrano-Aroca; Gajendra Kumar Azad; Alaa A A Aljabali; Giorgio Palu; Tarek Mohamed Abd El-Aziz; Debmalya Barh; Bruce D Uhal; Parise Adadi; Kazuo Takayama; Nicolas G Bazan; Murtaza Tambuwala; Samendra P Sherchan; Amos Lal; Gaurav Chauhan; Wagner Baetas-da-Cruz; Vladimir N Uversky

  International journal of biological macromolecules, 01 Dec. 2022

  
• Exocyst complex component 2 is a potential host factor for SARS-CoV-2 infection.

  Renxing Yi; Rina Hashimoto; Ayaka Sakamoto; Yasufumi Matsumura; Miki Nagao; Kazutoshi Takahashi; Kazuo Takayama

  iScience, 18 Nov. 2022

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• Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant.

  Akatsuki Saito; Tomokazu Tamura; Jiri Zahradnik; Sayaka Deguchi; Koshiro Tabata; Yuki Anraku; Izumi Kimura; Jumpei Ito; Daichi Yamasoba; Hesham Nasser; Mako Toyoda; Kayoko Nagata; Keiya Uriu; Yusuke Kosugi; Shigeru Fujita; Maya Shofa; Mst Monira Begum; Ryo Shimizu; Yoshitaka Oda; Rigel Suzuki; Hayato Ito; Naganori Nao; Lei Wang; Masumi Tsuda; Kumiko Yoshimatsu; Jin Kuramochi; Shunsuke Kita; Kaori Sasaki-Tabata; Hideo Fukuhara; Katsumi Maenaka; Yuki Yamamoto; Tetsuharu Nagamoto; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Takamasa Ueno; Gideon Schreiber; Akifumi Takaori-Kondo; Kotaro Shirakawa; Hirofumi Sawa; Takashi Irie; Takao Hashiguchi; Kazuo Takayama; Keita Matsuno; Shinya Tanaka; Terumasa Ikeda; Takasuke Fukuhara; Kei Sato

  Cell host & microbe, 09 Nov. 2022

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• Therapeutic Potential of Cannabinoids on Tumor Microenvironment: A Molecular Switch in Neoplasia Transformation.

  Hamid A Bakshi; Hakkim L Faruck; Zeinab Ravesh; Prawej Ansari; J M A Hannan; Rina Hashimoto; Kazuo Takayama; Rabia Farzand; Mohamed M Nasef; Adelaide Mensah; Alaa A A Aljabali; Vijay Mishra; Nitin B Charbe; Rohit Goyal; Poonam Negi; Ángel Serrano-Aroca; Bojlul Bahar; Mohamed El-Tanani; Aaron J Courtenay; Paul McCarron; Iain G Jack; Murtaza M Tambuwala

  Integrative cancer therapies, 2022

  
• Intestinal Permeability of Drugs in Caco-2 Cells Cultured in Microfluidic Devices.

  Yuko Sasaki; Hirotaka Tatsuoka; Masahiro Tsuda; Takumi Sumi; Yuka Eguchi; Kanako So; Yuriko Higuchi; Kazuo Takayama; Yusuke Torisawa; Fumiyoshi Yamashita

  Biological & pharmaceutical bulletin, 2022, Peer-reviewed

  
• Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models.

  Maaya Morita; Aki Yoneda; Nagisa Tokunoh; Tatsumi Masaki; Keisuke Shirakura; Mayumi Kinoshita; Rina Hashimoto; Naoya Shigesada; Junya Takahashi; Masashi Tachibana; Shota Tanaka; Masanori Obana; Nobumasa Hino; Masahito Ikawa; Kazutake Tsujikawa; Chikako Ono; Yoshiharu Matsuura; Hiroyasu Kidoya; Nobuyuki Takakura; Yoshiaki Kubota; Takefumi Doi; Kazuo Takayama; Yasuo Yoshioka; Yasushi Fujio; Yoshiaki Okada

  Proceedings of the National Academy of Sciences of the United States of America, 17 Jan. 2023

  
• State-of-the-art liver disease research using liver-on-a-chip.

  Sayaka Deguchi; Kazuo Takayama

  Inflammation and regeneration, 09 Dec. 2022

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• Application of perfluoropolyether elastomers in microfluidic drug metabolism assays.

  Mengyang Wang; Masahiro Tsuda; Sayaka Deguchi; Yuriko Higuchi; Kanako So; Yu-Suke Torisawa; Kazuo Takayama; Fumiyoshi Yamashita

  International journal of pharmaceutics, 05 Nov. 2022

  
• SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression.

  Rina Hashimoto; Junya Takahashi; Keisuke Shirakura; Risa Funatsu; Kaori Kosugi; Sayaka Deguchi; Masaki Yamamoto; Yugo Tsunoda; Maaya Morita; Kosuke Muraoka; Masato Tanaka; Tomoaki Kanbara; Shota Tanaka; Shigeyuki Tamiya; Nagisa Tokunoh; Atsushi Kawai; Masahito Ikawa; Chikako Ono; Keisuke Tachibana; Masuo Kondoh; Masanori Obana; Yoshiharu Matsuura; Akihiro Ohsumi; Takeshi Noda; Takuya Yamamoto; Yasuo Yoshioka; Yu-Suke Torisawa; Hiroshi Date; Yasushi Fujio; Miki Nagao; Kazuo Takayama; Yoshiaki Okada

  Science advances, 23 Sep. 2022

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• Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System.

  Ryosuke Negoro; Mitsuki Tasaka; Sayaka Deguchi; Kazuo Takayama; Takuya Fujita

  Cells, 18 May 2022

  
• Decellularized Organ-Derived Scaffold Is a Promising Carrier for Human Induced Pluripotent Stem Cells-Derived Hepatocytes.

  Hideaki Kojima; Hiroshi Yagi; Hiroko Kushige; Yukiko Toda; Kazuo Takayama; Shinako Masuda; Toshinori Morisaku; Tomonori Tsuchida; Kohei Kuroda; Kazuya Hirukawa; Jumpei Inui; Kotaro Nishi; Yutaka Nakano; Masayuki Tanaka; Shutaro Hori; Yasushi Hasegawa; Yuta Abe; Minoru Kitago; Shungo Adachi; Masatoshi Tomi; Katsuhisa Matsuura; Hiroyuki Mizuguchi; Yuko Kitagawa

  Cells, 07 Apr. 2022

  
• Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2.

  Alba Cano-Vicent; Rina Hashimoto; Kazuo Takayama; Ángel Serrano-Aroca

  Polymers, 06 Apr. 2022

  
• An issue of concern: unique truncated ORF8 protein variants of SARS-CoV-2.

  Sk Sarif Hassan; Vaishnavi Kodakandla; Elrashdy M Redwan; Kenneth Lundstrom; Pabitra Pal Choudhury; Tarek Mohamed Abd El-Aziz; Kazuo Takayama; Ramesh Kandimalla; Amos Lal; Ángel Serrano-Aroca; Gajendra Kumar Azad; Alaa A A Aljabali; Giorgio Palù; Gaurav Chauhan; Parise Adadi; Murtaza Tambuwala; Adam M Brufsky; Wagner Baetas-da-Cruz; Debmalya Barh; Vasco Azevedo; Nikolas G Bazan; Bruno Silva Andrade; Raner José Santana Silva; Vladimir N Uversky

  PeerJ, 2022

  
• Cell response analysis in SARS-CoV-2 infected bronchial organoids

  Emi Sano; Tatsuya Suzuki; Rina Hashimoto; Yumi Itoh; Ayaka Sakamoto; Yusuke Sakai; Akatsuki Saito; Daisuke Okuzaki; Daisuke Motooka; Yukiko Muramoto; Takeshi Noda; Tomohiko Takasaki; Jun-Ichi Sakuragi; Shohei Minami; Takeshi Kobayashi; Takuya Yamamoto; Yasufumi Matsumura; Miki Nagao; Toru Okamoto; Kazuo Takayama

  Communications Biology, Dec. 2022, Peer-reviewed

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• Dual inhibition of TMPRSS2 and Cathepsin Bprevents SARS-CoV-2 infection in iPS cells.

  Rina Hashimoto; Ayaka Sakamoto; Sayaka Deguchi; Renxing Yi; Emi Sano; Akitsu Hotta; Kazutoshi Takahashi; Shinya Yamanaka; Kazuo Takayama

  Molecular therapy. Nucleic acids, 03 Dec. 2021

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• Clinical utility of novel biosensing platform: Diagnosis of coronavirus SARS-CoV-2 at point of care.

  Alaa A A Aljabali; Kaushik Pal; Angel Serrano-Aroca; Kazuo Takayama; Kamal Dua; Murtaza M Tambuwala

  Materials letters, 01 Dec. 2021

  
• Protective Face Masks: Current Status and Future Trends.

  Alberto Tuñón-Molina; Kazuo Takayama; Elrashdy M Redwan; Vladimir N Uversky; Juan Andrés; Ángel Serrano-Aroca

  ACS applied materials & interfaces, 19 Nov. 2021

  
• Generation of Tetrafluoroethylene-Propylene Elastomer-Based Microfluidic Devices for Drug Toxicity and Metabolism Studies.

  Emi Sano; Sayaka Deguchi; Naoki Matsuoka; Masahiro Tsuda; Mengyang Wang; Kaori Kosugi; Chihiro Mori; Keisuke Yagi; Aya Wada; Shinsuke Yamasaki; Tsuyoshi Kawai; Masahide Yodogawa; Hiroyuki Mizuguchi; Norihito Nakazawa; Fumiyoshi Yamashita; Yu-Suke Torisawa; Kazuo Takayama

  ACS omega, 28 Sep. 2021

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• Potential Molecular Mechanisms of Rare Anti-Tumor Immune Response by SARS-CoV-2 in Isolated Cases of Lymphomas.

  Debmalya Barh; Sandeep Tiwari; Lucas Gabriel Rodrigues Gomes; Marianna E Weener; Khalid J Alzahrani; Khalaf F Alsharif; Alaa A A Aljabali; Murtaza M Tambuwala; Kenneth Lundstrom; Sk Sarif Hassan; Ángel Serrano-Aroca; Kazuo Takayama; Preetam Ghosh; Elrashdy M Redwan; Bruno Silva Andrade; Siomar de Castro Soares; Vasco Azevedo; Vladimir N Uversky

  Viruses, 25 Sep. 2021

  
• Implications derived from S-protein variants of SARS-CoV-2 from six continents.

  Sk Sarif Hassan; Kenneth Lundstrom; Debmalya Barh; Raner Jośe Santana Silva; Bruno Silva Andrade; Vasco Azevedo; Pabitra Pal Choudhury; Giorgio Palu; Bruce D Uhal; Ramesh Kandimalla; Murat Seyran; Amos Lal; Samendra P Sherchan; Gajendra Kumar Azad; Alaa A A Aljabali; Adam M Brufsky; Ángel Serrano-Aroca; Parise Adadi; Tarek Mohamed Abd El-Aziz; Elrashdy M Redwan; Kazuo Takayama; Nima Rezaei; Murtaza Tambuwala; Vladimir N Uversky

  International journal of biological macromolecules, 24 Sep. 2021

  
• Periodically aperiodic pattern of SARS-CoV-2 mutations underpins the uncertainty of its origin and evolution.

  Sk Sarif Hassan; Pallab Basu; Elrashdy M Redwan; Kenneth Lundstrom; Pabitra Pal Choudhury; Angel Serrano-Aroca; Gajendra Kumar Azad; Alaa A A Aljabali; Giorgio Palu; Tarek Mohamed Abd El-Aziz; Debmalya Barh; Bruce D Uhal; Parise Adadi; Kazuo Takayama; Nicolas G Bazan; Murtaza Tambuwala; Amos Lal; Gaurav Chauhan; Wagner Baetas-da-Cruz; Samendra P Sherchan; Vladimir N Uversky

  Environmental research, 22 Sep. 2021

  
• Antiviral Face Mask Functionalized with Solidified Hand Soap: Low-Cost Infection Prevention Clothing against Enveloped Viruses Such as SARS-CoV-2.

  Alba Cano-Vicent; Alberto Tuñón-Molina; Miguel Martí; Yukiko Muramoto; Takeshi Noda; Kazuo Takayama; Ángel Serrano-Aroca

  ACS omega, 14 Sep. 2021

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• Autoimmunity roots of the thrombotic events after COVID-19 vaccination.

  Fatma Elrashdy; Murtaza M Tambuwala; Sk Sarif Hassan; Parise Adadi; Murat Seyran; Tarek Mohamed Abd El-Aziz; Nima Rezaei; Amos Lal; Alaa A A Aljabali; Ramesh Kandimalla; Nicolas G Bazan; Gajendra Kumar Azad; Samendra P Sherchan; Pabitra Pal Choudhury; Ángel Serrano-Aroca; Kazuo Takayama; Gaurav Chauhan; Damiano Pizzol; Debmalya Barh; Pritam Kumar Panda; Yogendra K Mishra; Giorgio Palù; Kenneth Lundstrom; Elrashdy M Redwan; Vladimir N Uversky

  Autoimmunity reviews, 09 Sep. 2021

  
• Antimicrobial Face Shield: Next Generation of Facial Protective Equipment against SARS-CoV-2 and Multidrug-Resistant Bacteria.

  Alberto Tuñón-Molina; Miguel Martí; Yukiko Muramoto; Takeshi Noda; Kazuo Takayama; Ángel Serrano-Aroca

  International journal of molecular sciences, 01 Sep. 2021

  
• Usability of Polydimethylsiloxane-Based Microfluidic Devices in Pharmaceutical Research Using Human Hepatocytes.

  Sayaka Deguchi; Masahiro Tsuda; Kaori Kosugi; Ayaka Sakamoto; Natsumi Mimura; Ryosuke Negoro; Emi Sano; Takuro Nobe; Kazuya Maeda; Hiroyuki Kusuhara; Hiroyuki Mizuguchi; Fumiyoshi Yamashita; Yu-Suke Torisawa; Kazuo Takayama

  ACS biomaterials science & engineering, 09 Aug. 2021

  
• In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology.

  Sayaka Deguchi; Tomohiro Shintani; Kazuo Harada; Toru Okamoto; Akinori Takemura; Kazumasa Hirata; Kousei Ito; Kazuo Takayama; Hiroyuki Mizuguchi

  Hepatology communications, Aug. 2021

  
• SARS-CoV-2 research using human pluripotent stem cells and organoids.

  Sayaka Deguchi; Ángel Serrano-Aroca; Murtaza M Tambuwala; Bruce D Uhal; Adam M Brufsky; Kazuo Takayama

  Stem cells translational medicine, 24 Jul. 2021

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• The mechanism behind flaring/triggering of autoimmunity disorders associated with COVID-19.

  Elrashdy M Redwan; Mohammed F Alghamdi; Tarek Mohamed Abd El-Aziz; Parise Adadi; Alaa A A Aljabali; Diksha Attrish; Gajendra Kumar Azad; Wagner Baetas-da-Cruz; Debmalya Barh; Nicolas G Bazan; Adam M Brufsky; Gaurav Chauhan; S K Sarif Hassan; Ramesh Kandimalla; Amos Lal; Kenneth Lundstrom; Yogendra Kumar Mishra; Pabitra Pal Choudhury; Giorgio Palù; Pritam K Panda; Damiano Pizzol; Nima Rezaei; Ángel Serrano-Aroca; Samendra P Sherchan; Murat Seyran; Kazuo Takayama; Murtaza M Tambuwala; Bruce D Uhal; Vladimir N Uversky

  Autoimmunity reviews, 16 Jul. 2021

  
• Targeting LIN28: a new hope in prostate cancer theranostics.

  Garima Shrivastava; Alaa Aa Aljabali; Seyed Hossein Shahcheraghi; Marzieh Lotfi; Madhur D Shastri; Shakti D Shukla; Dinesh K Chellappan; Niraj Kumar Jha; Krishnan Anand; Harish Dureja; Ritesh M Pabari; Vijay Mishra; Abdulmajeed G Almutary; Abdullah M Alnuqaydan; Nitin Charbe; Parteek Prasher; Poonam Negi; Rohit Goyal; Kamal Dua; Gaurav Gupta; Ángel Serrano-Aroca; Bojlul Bahar; Debmalya Barh; Pritam Kumar Panda; Kazuo Takayama; Kenneth Lundstrom; Paul McCarron; Hamid Bakshi; Murtaza M Tambuwala

  Future oncology (London, England), 15 Jul. 2021

  
• COVID-19 Vaccines and Thrombosis-Roadblock or Dead-End Street?

  Kenneth Lundstrom; Debmalya Barh; Bruce D Uhal; Kazuo Takayama; Alaa A A Aljabali; Tarek Mohamed Abd El-Aziz; Amos Lal; Elrashdy M Redwan; Parise Adadi; Gaurav Chauhan; Samendra P Sherchan; Gajendra Kumar Azad; Nima Rezaei; Ángel Serrano-Aroca; Nicolas G Bazan; Sk Sarif Hassan; Pritam Kumar Panda; Pabitra Pal Choudhury; Damiano Pizzol; Ramesh Kandimalla; Wagner Baetas-da-Cruz; Yogendra Kumar Mishra; Giorgio Palu; Adam M Brufsky; Murtaza M Tambuwala; Vladimir N Uversky

  Biomolecules, 13 Jul. 2021

  
• Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system.

  Moe Ichikawa; Hiroki Akamine; Michika Murata; Sumito Ito; Kazuo Takayama; Hiroyuki Mizuguchi

  Scientific reports, 03 Jun. 2021

  
• A unique view of SARS-CoV-2 through the lens of ORF8 protein.

  Sk Sarif Hassan; Alaa A A Aljabali; Pritam Kumar Panda; Shinjini Ghosh; Diksha Attrish; Pabitra Pal Choudhury; Murat Seyran; Damiano Pizzol; Parise Adadi; Tarek Mohamed Abd El-Aziz; Antonio Soares; Ramesh Kandimalla; Kenneth Lundstrom; Amos Lal; Gajendra Kumar Azad; Vladimir N Uversky; Samendra P Sherchan; Wagner Baetas-da-Cruz; Bruce D Uhal; Nima Rezaei; Gaurav Chauhan; Debmalya Barh; Elrashdy M Redwan; Guy W Dayhoff 2nd; Nicolas G Bazan; Ángel Serrano-Aroca; Amr El-Demerdash; Yogendra K Mishra; Giorgio Palu; Kazuo Takayama; Adam M Brufsky; Murtaza M Tambuwala

  Computers in biology and medicine, Jun. 2021

  
• Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial-Resistant Era.

  Ángel Serrano-Aroca; Kazuo Takayama; Alberto Tuñón-Molina; Murat Seyran; Sk Sarif Hassan; Pabitra Pal Choudhury; Vladimir N Uversky; Kenneth Lundstrom; Parise Adadi; Giorgio Palù; Alaa A A Aljabali; Gaurav Chauhan; Ramesh Kandimalla; Murtaza M Tambuwala; Amos Lal; Tarek Mohamed Abd El-Aziz; Samendra Sherchan; Debmalya Barh; Elrashdy M Redwan; Nicolas G Bazan; Yogendra Kumar Mishra; Bruce D Uhal; Adam Brufsky

  ACS nano, 25 May 2021

  
• Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells.

  Emi Sano; Sayaka Deguchi; Ayaka Sakamoto; Natsumi Mimura; Ai Hirabayashi; Yukiko Muramoto; Takeshi Noda; Takuya Yamamoto; Kazuo Takayama

  iScience, 21 May 2021

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• Overview of key molecular and pharmacological targets for diabetes and associated diseases.

  Seyed Hossein Shahcheraghi; Alaa A A Aljabali; Mazhar S Al Zoubi; Vijay Mishra; Nitin B Charbe; Yusuf A Haggag; Garima Shrivastava; Abdulmajeed G Almutary; Abdullah M Alnuqaydan; Debmalya Barh; Kamal Dua; Dinesh K Chellappan; Gaurav Gupta; Marzieh Lotfi; Ángel Serrano-Aroca; Bojlul Bahar; Yogendra Kumar Mishra; Kazuo Takayama; Pritam Kumar Panda; Hamid A Bakshi; Murtaza M Tambuwala

  Life sciences, 18 May 2021

  
• Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2.

  Sk Sarif Hassan; Diksha Attrish; Shinjini Ghosh; Pabitra Pal Choudhury; Vladimir N Uversky; Alaa A A Aljabali; Kenneth Lundstrom; Bruce D Uhal; Nima Rezaei; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza M Tambuwala; Gajendra Kumar Azad; Samendra P Sherchan; Wagner Baetas-da-Cruz; Amos Lal; Giorgio Palù; Kazuo Takayama; Ángel Serrano-Aroca; Debmalya Barh; Adam M Brufsky

  International journal of biological macromolecules, 16 Apr. 2021

  
• Asymmetric profiles of infection and innate immunological responses in human iPS cell-derived small intestinal epithelial-like cell monolayers following infection with mammalian reovirus.

  Chieko Inoue; Ryosuke Negoro; Kazuo Takayama; Hiroyuki Mizuguchi; Fuminori Sakurai

  Virus research, 15 Apr. 2021

  
• Vinblastine treatment decreases the undifferentiated cell contamination of human iPSC-derived intestinal epithelial-like cells.

  Moe Ichikawa; Ryosuke Negoro; Kanae Kawai; Tomoki Yamashita; Kazuo Takayama; Hiroyuki Mizuguchi

  Molecular therapy. Methods & clinical development, 12 Mar. 2021

  
• In Vivo Gene Expression Profile of Human Intestinal Epithelial Cells: From the Viewpoint of Drug Metabolism and Pharmacokinetics.

  Kazuo Takayama; Kohei Ito; Akiko Matsui; Tomoki Yamashita; Kentaro Kawakami; Daisuke Hirayama; Wataru Kishimoto; Hiroshi Nakase; Hiroyuki Mizuguchi

  Drug metabolism and disposition: the biological fate of chemicals, Mar. 2021

  
• Protective Face Mask Filter Capable of Inactivating SARS-CoV-2, and Methicillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis.

  Miguel Martí; Alberto Tuñón-Molina; Finn Lillelund Aachmann; Yukiko Muramoto; Takeshi Noda; Kazuo Takayama; Ángel Serrano-Aroca

  Polymers, 08 Jan. 2021

  
• Generation of Hepatocytes from Human ES/iPS Cells for Regenerative Medicine

  Tomoki Yamashita; Kazuo Takayama; Hiroyuki Mizuguchi

  Cell-Inspired Materials and Engineering, 2021

  
• Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features.

  Sk Sarif Hassan; Shinjini Ghosh; Diksha Attrish; Pabitra Pal Choudhury; Alaa A A Aljabali; Bruce D Uhal; Kenneth Lundstrom; Nima Rezaei; Vladimir N Uversky; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza M Tambuwala; Gajendra Kumar Azad; Samendra P Sherchan; Wagner Baetas-da-Cruz; Kazuo Takayama; Ángel Serrano-Aroca; Gaurav Chauhan; Giorgio Palu; Adam M Brufsky

  Molecules (Basel, Switzerland), 13 Dec. 2020

  
• Introductions to the Community: Early-Career Researchers in the Time of COVID-19.

  Kazuo Takayama; Lesley N Weaver; Edroaldo Lummertz da Rocha; Valentina Lo Sardo; Helmuth Gehart; Ly P Vu

  Cell stem cell, 03 Dec. 2020

  
• The structural basis of accelerated host cell entry by SARS-CoV-2†.

  Murat Seyran; Kazuo Takayama; Vladimir N Uversky; Kenneth Lundstrom; Giorgio Palù; Samendra P Sherchan; Diksha Attrish; Nima Rezaei; Alaa A A Aljabali; Shinjini Ghosh; Damiano Pizzol; Gaurav Chauhan; Parise Adadi; Tarek Mohamed Abd El-Aziz; Antonio G Soares; Ramesh Kandimalla; Murtaza Tambuwala; Sk Sarif Hassan; Gajendra Kumar Azad; Pabitra Pal Choudhury; Wagner Baetas-da-Cruz; Ángel Serrano-Aroca; Adam M Brufsky; Bruce D Uhal

  The FEBS journal, 02 Dec. 2020

  
• Photoactivatable oncolytic adenovirus for optogenetic cancer therapy.

  Yasuko Hagihara; Ayaka Sakamoto; Takashi Tokuda; Tomoki Yamashita; Sena Ikemoto; Ayaka Kimura; Makito Haruta; Kiyotaka Sasagawa; Jun Ohta; Kazuo Takayama; Hiroyuki Mizuguchi

  Cell death & disease, 23 Jul. 2020

  
• Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies.

  Kanae Kawai; Ryosuke Negoro; Moe Ichikawa; Tomoki Yamashita; Sayaka Deguchi; Kazuo Harada; Kazumasa Hirata; Kazuo Takayama; Hiroyuki Mizuguchi

  Molecular therapy. Methods & clinical development, 12 Jun. 2020, Peer-reviewed

  
• In Vitro and Animal Models for SARS-CoV-2 research.

  Kazuo Takayama

  Trends in pharmacological sciences, 30 May 2020, Peer-reviewed

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• Tolloid-Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling.

  Ayumi Kiso; Yukiko Toba; Susumu Tsutsumi; Sayaka Deguchi; Keisuke Igai; Saki Koshino; Yasuhito Tanaka; Kazuo Takayama; Hiroyuki Mizuguchi

  Hepatology communications, Feb. 2020, Peer-reviewed

  
• Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance.

  Yukiko Toba; Sayaka Deguchi; Natsumi Mimura; Ayaka Sakamoto; Kazuo Harada; Kazumasa Hirata; Kazuo Takayama; Hiroyuki Mizuguchi

  PloS one, 2020, Peer-reviewed

  
• Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells.

  Sayaka Deguchi; Tomoki Yamashita; Keisuke Igai; Kazuo Harada; Yukiko Toba; Kazumasa Hirata; Kazuo Takayama; Hiroyuki Mizuguchi

  Drug metabolism and disposition: the biological fate of chemicals, Jun. 2019, Peer-reviewed

  
• FGF signal is not required for hepatoblast differentiation of human iPS cells.

  Yukiko Toba; Ayumi Kiso; Souichiro Nakamae; Fuminori Sakurai; Kazuo Takayama; Hiroyuki Mizuguchi

  Scientific reports, 06 Mar. 2019, Peer-reviewed

  
• Pharmaceutical Research for Inherited Metabolic Disorders of the Liver Using Human Induced Pluripotent Stem Cell and Genome Editing Technologies.

  Tomoki Yamashita; Kazuo Takayama; Mika Hori; Mariko Harada-Shiba; Hiroyuki Mizuguchi

  Biological & pharmaceutical bulletin, 2019, Peer-reviewed

  
• Generation of Human iPSC-Derived Intestinal Epithelial Cell Monolayers by CDX2 Transduction.

  Kazuo Takayama; Ryosuke Negoro; Tomoki Yamashita; Kanae Kawai; Moe Ichikawa; Takanori Mori; Noriyuki Nakatsu; Kazuo Harada; Sumito Ito; Hiroshi Yamada; Yoshiyuki Yamaura; Kazumasa Hirata; Seiichi Ishida; Hiroyuki Mizuguchi

  Cellular and molecular gastroenterology and hepatology, 2019, Peer-reviewed

  
• [Pharmaceutical Research on Liver Diseases Using iPS Cell and Genome Editing Technologies].

  Kazuo Takayama

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2019, Peer-reviewed

  
• Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies.

  Ryosuke Negoro; Kazuo Takayama; Kanae Kawai; Kazuo Harada; Fuminori Sakurai; Kazumasa Hirata; Hiroyuki Mizuguchi

  Stem cell reports, 11 Dec. 2018, Peer-reviewed

  
• Optimal human iPS cell culture method for efficient hepatic differentiation.

  Matoba N; Yamashita T; Takayama K; Sakurai F; Mizuguchi H

  Differentiation; research in biological diversity, Sep. 2018, Peer-reviewed

  
• Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research.

  Kazuo Takayama; Yasuko Hagihara; Yukiko Toba; Kiyotoshi Sekiguchi; Fuminori Sakurai; Hiroyuki Mizuguchi

  Biomaterials, Apr. 2018, Peer-reviewed

  
• Nanaomycin A Treatment Promotes Hepatoblast Differentiation from Human iPS Cells.

  Souichiro Nakamae; Yukiko Toba; Kazuo Takayama; Fuminori Sakurai; Hiroyuki Mizuguchi

  Stem cells and development, 15 Mar. 2018, Peer-reviewed

  
• Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells.

  Tomoki Yamashita; Kazuo Takayama; Fuminori Sakurai; Hiroyuki Mizuguchi

  Biochemical and biophysical research communications, 19 Feb. 2018, Peer-reviewed

  
• Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy.

  Kazuo Takayama; Hiroyuki Mizuguchi

  ACS chemical biology, 16 Feb. 2018, Peer-reviewed

  
• Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B.

  Ryota Okamoto; Kazuo Takayama; Naoki Akita; Yasuhito Nagamoto; Daiki Hosokawa; Shunsuke Iizuka; Fuminori Sakurai; Hiroshi Suemizu; Kazuo Ohashi; Hiroyuki Mizuguchi

  Cell transplantation, Feb. 2018, Peer-reviewed

  
• Generation of safe and therapeutically effective human induced pluripotent stem cell-derived hepatocyte-like cells for regenerative medicine.

  Kazuo Takayama; Naoki Akita; Natsumi Mimura; Rina Akahira; Yukimasa Taniguchi; Makoto Ikeda; Fuminori Sakurai; Osamu Ohara; Tomohiro Morio; Kiyotoshi Sekiguchi; Hiroyuki Mizuguchi

  Hepatology communications, Dec. 2017, Peer-reviewed

  
• y Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction

  Daiki Nakamori; Hiroki Akamine; Kazuo Takayama; Fuminori Sakurai; Hiroyuki Mizuguchi

  SCIENTIFIC REPORTS, Nov. 2017, Peer-reviewed

  
• Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells

  Fuminori Sakurai; Takemaru Kunito; Kazuo Takayama; Rina Hashimoto; Masashi Tachibana; Naoya Sakamoto; Takaji Wakita; Hiroyuki Mizuguchi

  VIRUS RESEARCH, Oct. 2017, Peer-reviewed

  
• Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation from Human Induced Pluripotent Stem Cells

  Morifumi Hanawa; Kazuo Takayama; Fuminori Sakurai; Masashi Tachibana; Hiroyuki Mizuguchi

  STEM CELL REVIEWS AND REPORTS, Aug. 2017, Peer-reviewed

  
• Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling

  Seiji Mitani; Kazuo Takayama; Yasuhito Nagamoto; Kazuo Imagawa; Fuminori Sakurai; Masashi Tachibana; Ryo Sumazaki; Hiroyuki Mizuguchi

  MOLECULAR THERAPY, Jun. 2017, Peer-reviewed

  
• Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system

  Kazuo Takayama; Keisuke Igai; Yasuko Hagihara; Rina Hashimoto; Morifumi Hanawa; Tetsushi Sakuma; Masashi Tachibana; Fuminori Sakurai; Takashi Yamamoto; Hiroyuki Mizuguchi

  NUCLEIC ACIDS RESEARCH, May 2017, Peer-reviewed

  
• Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection

  Fuminori Sakurai; Seiji Mitani; Tatsuro Yamamoto; Kazuo Takayama; Masashi Tachibana; Koichi Watashi; Takaji Wakita; Sayuki Iijima; Yasuhito Tanaka; Hiroyuki Mizuguchi

  SCIENTIFIC REPORTS, Apr. 2017, Peer-reviewed

  
• Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions

  Takayuki Fukuda; Kazuo Takayama; Mitsuhi Hirata; Yu-Jung Liu; Kana Yanagihara; Mika Suga; Hiroyuki Mizuguchi; Miho K. Furue

  EXPERIMENTAL CELL RESEARCH, Mar. 2017, Peer-reviewed

  
• Inhibition of CRISPR/Cas9-Mediated Genome Engineering by a Type I Interferon-Induced Reduction in Guide RNA Expression

  Mitsuhiro Machitani; Fuminori Sakurai; Keisaku Wakabayashi; Kosuke Nakatani; Kazuo Takayama; Masashi Tachibana; Hiroyuki Mizuguhi

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Mar. 2017, Peer-reviewed

  
• Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells

  Kazuo Imagawa; Kazuo Takayama; Shigemi Isoyama; Ken Tanikawa; Masato Shinkai; Kazuo Harada; Masashi Tachibana; Fuminori Sakurai; Emiko Noguchi; Kazumasa Hirata; Masayoshi Kage; Kenji Kawabata; Ryo Sumazaki; Hiroyuki Mizuguchi

  Scientific Reports, Feb. 2017, Peer-reviewed

  
• Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening

  Kazuo Takayama; Hiroyuki Mizuguchi

  DRUG METABOLISM AND PHARMACOKINETICS, Feb. 2017, Peer-reviewed

  
• Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells

  Kana Yanagihara; Yujung Liu; Kei Kanie; Kazuo Takayama; Minako Kokunugi; Mitsuhi Hirata; Takayuki Fukuda; Mika Suga; Hiroki Nikawa; Hiroyuki Mizuguchi; Ryuji Kato; Miho K. Furue

  STEM CELLS AND DEVELOPMENT, Dec. 2016, Peer-reviewed

  
• Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure

  Yasuhito Nagamoto; Kazuo Takayama; Kazuo Ohashi; Ryota Okamoto; Fuminori Sakurai; Masashi Tachibana; Kenji Kawabata; Hiroyuki Mizuguchi

  JOURNAL OF HEPATOLOGY, May 2016, Peer-reviewed

  
• Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells

  Kazuo Takayama; Seiji Mitani; Yasuhito Nagamoto; Fuminori Sakurai; Masashi Tachibana; Yukimasa Taniguchi; Kiyotoshi Sekiguchi; Hiroyuki Mizuguchi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, May 2016, Peer-reviewed

  
• Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cellst

  Ryosuke Negoro; Kazuo Takayama; Yasuhito Nagamoto; Fuminori Sakurai; Masashi Tachibana; Hiroyuki Mizuguchi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Apr. 2016, Peer-reviewed

  
• Hepatic maturation of human iPS cell-derived hepatocyte-like cells by ATF5, c/EBP alpha, and PROX1 transduction

  Daiki Nakamori; Kazuo Takayama; Yasuhito Nagamoto; Seiji Mitani; Fuminori Sakurai; Masashi Tachibana; Hiroyuki Mizuguchi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Jan. 2016, Peer-reviewed

  
• Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine

  Tatsuya Ozawa; Kazuo Takayama; Ryota Okamoto; Ryosuke Negoro; Fuminori Sakurai; Masashi Tachibana; Kenji Kawabata; Hiroyuki Mizuguchi

  SCIENTIFIC REPORTS, Nov. 2015, Peer-reviewed

  
• Establishment of a Method of Hepatocyte Differentiation from Human Pluripotent Stem Cells for Innovative Drug Development

  Kazuo Takayama

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Oct. 2015, Peer-reviewed

  
• Generation of Brain Microvascular Endothelial-Like Cells from Human Induced Pluripotent Stem Cells by Co-Culture with C6 Glioma Cells

  Haruka Minami; Katsuhisa Tashiro; Atsumasa Okada; Nobue Hirata; Tomoko Yamaguchi; Kazuo Takayama; Hiroyuki Mizuguchi; Kenji Kawabata

  PLOS ONE, Jun. 2015, Peer-reviewed

  
• Expression of Coxsackievirus and Adenovirus Receptor Separates Hematopoietic and Cardiac Progenitor Cells in Fetal Liver Kinase 1-Expressing Mesoderm

  Katsuhisa Tashiro; Nobue Hirata; Atsumasa Okada; Tomoko Yamaguchi; Kazuo Takayama; Hiroyuki Mizuguchi; Kenji Kawabata

  STEM CELLS TRANSLATIONAL MEDICINE, May 2015, Peer-reviewed

  
• Expression of Coxsackievirus and Adenovirus Receptor Separates Hematopoietic and Cardiac Progenitor Cells in Fetal Liver Kinase 1-Expressing Mesoderm

  Katsuhisa Tashiro; Nobue Hirata; Atsumasa Okada; Tomoko Yamaguchi; Kazuo Takayama; Hiroyuki Mizuguchi; Kenji Kawabata

  STEM CELLS TRANSLATIONAL MEDICINE, May 2015, Peer-reviewed

  
• Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene

  Yasuhito Nagamoto; Kazuo Takayama; Katsuhisa Tashiro; Chise Tateno; Fuminori Sakurai; Masashi Tachibana; Kenji Kawabata; Kazuo Ikeda; Yasuhito Tanaka; Hiroyuki Mizuguchi

  CELL TRANSPLANTATION, 2015, Peer-reviewed

  
• Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene

  Yasuhito Nagamoto; Kazuo Takayama; Katsuhisa Tashiro; Chise Tateno; Fuminori Sakurai; Masashi Tachibana; Kenji Kawabata; Kazuo Ikeda; Yasuhito Tanaka; Hiroyuki Mizuguchi

  CELL TRANSPLANTATION, 2015, Peer-reviewed

  
• Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes

  Kazuo Takayama; Yuta Morisaki; Shuichi Kuno; Yasuhito Nagamoto; Kazuo Harada; Norihisa Furukawa; Manami Ohtaka; Ken Nishimura; Kazuo Imagawa; Fuminori Sakurai; Masashi Tachibana; Ryo Sumazaki; Emiko Noguchi; Mahito Nakanishi; Kazumasa Hirata; Kenji Kawabata; Hiroyuki Mizuguchi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Nov. 2014, Peer-reviewed

  
• HHEX Promotes Hepatic-Lineage Specification through the Negative Regulation of Eomesodermin

  Hitoshi Watanabe; Kazuo Takayama; Mitsuru Inamura; Masashi Tachibana; Natsumi Mimura; Kazufumi Katayama; Katsuhisa Tashiro; Yasuhito Nagamoto; Fuminori Sakurai; Kenji Kawabata; Miho Kusuda Furue; Hiroyuki Mizuguchi

  PLOS ONE, Mar. 2014, Peer-reviewed

  
• CCAAT/enhancer binding protein-mediated regulation of TGF beta receptor 2 expression determines the hepatoblast fate decision

  Kazuo Takayama; Kenji Kawabata; Yasuhito Nagamoto; Mitsuru Inamura; Kazuo Ohashi; Hiroko Okuno; Tomoko Yamaguchi; Katsuhisa Tashiro; Fuminori Sakurai; Takao Hayakawa; Teruo Okano; Miho Kusada Furue; Hiroyuki Mizuguchi

  DEVELOPMENT, Jan. 2014, Peer-reviewed

  
• CCAAT/enhancer binding protein-mediated regulation of TGF beta receptor 2 expression determines the hepatoblast fate decision

  Kazuo Takayama; Kenji Kawabata; Yasuhito Nagamoto; Mitsuru Inamura; Kazuo Ohashi; Hiroko Okuno; Tomoko Yamaguchi; Katsuhisa Tashiro; Fuminori Sakurai; Takao Hayakawa; Teruo Okano; Miho Kusada Furue; Hiroyuki Mizuguchi

  DEVELOPMENT, Jan. 2014, Peer-reviewed

  
• Long-Term Self-Renewal of Human ES/iPS-Derived Hepatoblast-like Cells on Human Laminin 111-Coated Dishes

  Kazuo Takayama; Yasuhito Nagamoto; Natsumi Mimura; Katsuhisa Tashiro; Fuminori Sakurai; Masashi Tachibana; Takao Hayakawa; Kenji Kawabata; Hiroyuki Mizuguchi

  STEM CELL REPORTS, Oct. 2013, Peer-reviewed

  
• 3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing.

  Kazuo Takayama; Kenji Kawabata; Yasuhito Nagamoto; Keisuke Kishimoto; Katsuhisa Tashiro; Fuminori Sakurai; Masashi Tachibana; Katsuhiro Kanda; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi

  Biomaterials, Feb. 2013, Peer-reviewed

  
• Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1 alpha transduction

  Kazuo Takayama; Mitsuru Inamura; Kenji Kawabata; Michiko Sugawara; Kiyomi Kikuchi; Maiko Higuchi; Yasuhito Nagamoto; Hitoshi Watanabe; Katsuhisa Tashiro; Fuminori Sakurai; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi

  JOURNAL OF HEPATOLOGY, Sep. 2012, Peer-reviewed

  
• The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets

  Yasuhito Nagamoto; Katsuhisa Tashiro; Kazuo Takayama; Kazuo Ohashi; Kenji Kawabata; Fuminori Sakurai; Masashi Tachibana; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi

  BIOMATERIALS, Jun. 2012, Peer-reviewed

  
• Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4 alpha Transduction

  Kazuo Takayama; Mitsuru Inamura; Kenji Kawabata; Kazufumi Katayama; Maiko Higuchi; Katsuhisa Tashiro; Aki Nonaka; Fuminori Sakurai; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi

  MOLECULAR THERAPY, Jan. 2012, Peer-reviewed

  
• Efficient Generation of Functional Hepatocytes From Human Embryonic Stem Cells and Induced Pluripotent Stem Cells by HNF4 alpha Transduction

  Kazuo Takayama; Mitsuru Inamura; Kenji Kawabata; Kazufumi Katayama; Maiko Higuchi; Katsuhisa Tashiro; Aki Nonaka; Fuminori Sakurai; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi

  MOLECULAR THERAPY, Jan. 2012, Peer-reviewed

  
• Endodermal and Hepatic Differentiation from Human Embryonic Stem Cells and Human Induced Pluripotent Stem Cells.

  Kawabata K; Takayama K; Nagamoto Y; Saldon M.S; Higuchi M; Mizuguchi H

  J Stem Cell Res Ther., 2012, Peer-reviewed

  
• Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection

  Takeshi Yoshida; Kazuo Takayama; Masuo Kondoh; Fuminori Sakurai; Hideki Tani; Naoya Sakamoto; Yoshiharu Matsuura; Hiroyuki Mizuguchi; Kiyohito Yagi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Dec. 2011, Peer-reviewed

  
• Efficient and Directive Generation of Two Distinct Endoderm Lineages from Human ESCs and iPSCs by Differentiation Stage-Specific SOX17 Transduction

  Kazuo Takayama; Mitsuru Inamura; Kenji Kawabata; Katsuhisa Tashiro; Kazufumi Katayama; Fuminori Sakurai; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi

  PLOS ONE, Jul. 2011, Peer-reviewed

  
• Efficient Generation of Hepatoblasts From Human ES Cells and iPS Cells by Transient Overexpression of Homeobox Gene HEX

  Mitsuru Inamura; Kenji Kawabata; Kazuo Takayama; Katsuhisa Tashiro; Fuminori Sakurai; Kazufumi Katayama; Masashi Toyoda; Hidenori Akutsu; Yoshitaka Miyagawa; Hajime Okita; Nobutaka Kiyokawa; Akihiro Umezawa; Takao Hayakawa; Miho K. Furue; Hiroyuki Mizuguchi

  MOLECULAR THERAPY, Feb. 2011, Peer-reviewed

  
• Adenovirus Vector-Mediated Efficient Transduction into Human Embryonic and Induced Pluripotent Stem Cells

  Katsuhisa Tashiro; Kenji Kawabata; Mitsuru Inamura; Kazuo Takayama; Norihisa Furukawa; Fuminori Sakurai; Kazufumi Katayama; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi

  CELLULAR REPROGRAMMING, Oct. 2010, Peer-reviewed

  
• The importance of accessory protein variants in the pathogenicity of SARS-CoV-2.

  Sk Sarif Hassan; Pabitra Pal Choudhury; Guy W Dayhoff 2nd; Alaa A A Aljabali; Bruce D Uhal; Kenneth Lundstrom; Nima Rezaei; Damiano Pizzol; Parise Adadi; Amos Lal; Antonio Soares; Tarek Mohamed Abd El-Aziz; Adam M Brufsky; Gajendra Kumar Azad; Samendra P Sherchan; Wagner Baetas-da-Cruz; Kazuo Takayama; Ãngel Serrano-Aroca; Gaurav Chauhan; Giorgio Palu; Yogendra Kumar Mishra; Debmalya Barh; Raner Jośe Santana Silva; Bruno Silva Andrade; Vasco Azevedo; Aristóteles Góes-Neto; Nicolas G Bazan; Elrashdy M Redwan; Murtaza Tambuwala; Vladimir N Uversky

  Archives of biochemistry and biophysics, 15 Mar. 2022

  
• Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening.

  Tomohisa Tanaka; Akatsuki Saito; Tatsuya Suzuki; Yoichi Miyamoto; Kazuo Takayama; Toru Okamoto; Kohji Moriishi

  Antiviral research, 07 Mar. 2022

  
• Gene Therapy for Neuropsychiatric Disorders: Potential Targets and Tools.

  Seyed Hossein Shahcheraghi; Jamshid Ayatollahi; Marzieh Lotfi; Alaa A A Aljabali; Mazhar S Al-Zoubi; Pritam Kumar Panda; Vijay Mishra; Saurabh Satija; Nitin B Charbe; Ángel Serrano-Aroca; Bojlul Bahar; Kazuo Takayama; Rohit Goyal; Amit Bhatia; Abdulmajeed G Almutary; Abdullah M Alnuqaydan; Yachana Mishra; Poonam Negi; Aaron Courtney; Paul A McCarron; Hamid A Bakshi; Murtaza M Tambuwala

  CNS & neurological disorders drug targets, 04 Mar. 2022

  
• Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function.

  Sk Sarif Hassan; Kenneth Lundstrom; Ángel Serrano-Aroca; Parise Adadi; Alaa A A Aljabali; Elrashdy M Redwan; Amos Lal; Ramesh Kandimalla; Tarek Mohamed Abd El-Aziz; Pabitra Pal Choudhury; Gajendra Kumar Azad; Samendra P Sherchan; Gaurav Chauhan; Murtaza Tambuwala; Kazuo Takayama; Debmalya Barh; Giorgio Palu; Pallab Basu; Vladimir N Uversky

  International journal of biological macromolecules, 01 Jan. 2022

  
• Non-Woven Infection Prevention Fabrics Coated with Biobased Cranberry Extracts Inactivate Enveloped Viruses Such as SARS-CoV-2 and Multidrug-Resistant Bacteria.

  Kazuo Takayama; Alberto Tuñón-Molina; Alba Cano-Vicent; Yukiko Muramoto; Takeshi Noda; José Luis Aparicio-Collado; Roser Sabater I Serra; Miguel Martí; Ángel Serrano-Aroca

  International journal of molecular sciences, 24 Nov. 2021

  

Awards

• 05 Jan. 2024

  京都大学iPS細胞研究所 CiRA賞

External funds: Kakenhi

• Elucidation of the role of basal stem cells in respiratory diseases

  Grant-in-Aid for Scientific Research (B)

  Basic Section 90110:Biomedical engineering-related

  Kyoto University

  高山 和雄

  From 01 Apr. 2021, To 31 Mar. 2024, Granted

  基底細胞;気道;オルガノイド;感染症;臓器チップ;呼吸器感染症;SARS-CoV-2;気管支;iPS細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H03795/
• Elucidation of mechanism of chronic intestinal inflammation at single-cell level using optogenetic technique

  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)

  Osaka University

  高山 和雄

  From 01 Apr. 2018, To 31 Mar. 2020, Project Closed

  光操作;腸管上皮細胞;慢性炎症;腸炎;光遺伝学;ゲノム編集;１細胞;大腸がん;幹細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-18H05033/
• Generation of zone-specific hepatocyte for study of liver injury and diseases

  Grant-in-Aid for Challenging Research (Exploratory)

  Osaka University

  Kazuo Takayama

  From 30 Jun. 2017, To 31 Mar. 2019, Project Closed

  肝細胞;毒性;薬物代謝;zonation;ヒトiPS細胞;ヒトES細胞;肝障害;胆管上皮細胞;創薬;異物代謝;分化誘導;肝臓;ヒトES/iPS細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19657/
• Generation of CYP3A4-expressing human ES/iPS cell-derived hepatocytes for drug screening

  Grant-in-Aid for Research Activity Start-up

  Osaka University

  Kazuo Takayama

  From 28 Aug. 2015, To 31 Mar. 2017, Project Closed

  肝細胞;ヒトES/iPS細胞;薬物代謝;CYP;肝毒性;創薬試験;CYP3A4;ゲノム編集;薬物代謝酵素;相同組換え

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H06365/
• Microphysiological system-based analysis of inflammatory sprials triggered by abnormal gut motility

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47060:Clinical pharmacy-related

  Kyoto University

  山下 富義

  From 01 Apr. 2023, To 31 Mar. 2027, Granted

  生体模倣デバイス;腸運動;炎症性腸疾患;炎症スパイラル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02650/
• 血管バリアに着目する新しい視点での重症感染症の病態・後遺症発症機構の解明と制御

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related

  Osaka University

  岡田 欣晃

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  重症感染症;血管内皮細胞;血管バリア;罹患後症状;治療薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02629/
• Microphysiological system-based analysis of inflammatory sprials triggered by abnormal gut motility

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47060:Clinical pharmacy-related

  Kyoto University

  山下 富義

  From 01 Apr. 2023, To 31 Mar. 2027, Granted

  生体模倣デバイス;腸運動;炎症性腸疾患;炎症スパイラル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27341/
• 血管バリアに着目する新しい視点での重症感染症の病態・後遺症発症機構の解明と制御

  Grant-in-Aid for Scientific Research (B)

  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related

  Osaka University

  岡田 欣晃

  From 01 Apr. 2023, To 31 Mar. 2026, Granted

  重症感染症;血管内皮細胞;血管バリア;罹患後症状;治療薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27320/

External funds: others

• ＳＡＲＳ－ＣｏＶ－２の生活環を再現できるヒト肺モデルの開発と創薬応用 （2020年度分）

  京都発革新的医療技術研究開発助成事業

  From 01 Apr. 2020, To 31 Mar. 2021

  高山　和雄

Administration

Faculty management (title, position)

• From 01 Apr. 2022, To 31 Mar. 2026

  倫理審査委員会