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高山 和雄

タカヤマ カズオ

iPS細胞研究所 増殖分化機構研究部門 講師

高山 和雄
list
    Last Updated :2022/06/28

    基本情報

    学位

    • 修士(薬科学)(大阪大学)
    • 博士(薬科学)(大阪大学)

    経歴

    • 自 2020年03月, 至 現在
      京都大学iPS細胞研究所, 講師
    • 自 2016年10月, 至 2020年03月
      さきがけ研究者
    • 自 2018年02月, 至 2020年02月
      大阪大学大学院薬学研究科, 分子生物学分野, 助教
    • 自 2015年04月, 至 2018年01月
      大阪大学大学院薬学研究科附属創薬センター, Graduate School of Pharmaceutical Sciences, Drug Innovation Center, 特任助教
    • 自 2015年11月, 至 2017年03月
      K-CONNEX研究者

    使用言語

    • 日本語
    • 英語

    ID,URL

    researchmap URL

    list
      Last Updated :2022/06/28

      研究

      研究キーワード

      • 臓器チップ
      • SARS-CoV-2
      • iPS細胞
      • 多能性幹細胞
      • 創薬

      論文

      • Dual inhibition of TMPRSS2 and Cathepsin Bprevents SARS-CoV-2 infection in iPS cells.
        Rina Hashimoto; Ayaka Sakamoto; Sayaka Deguchi; Renxing Yi; Emi Sano; Akitsu Hotta; Kazutoshi Takahashi; Shinya Yamanaka; Kazuo Takayama
        Molecular therapy. Nucleic acids, 2021年12月03日
      • Clinical utility of novel biosensing platform: Diagnosis of coronavirus SARS-CoV-2 at point of care.
        Alaa A A Aljabali; Kaushik Pal; Angel Serrano-Aroca; Kazuo Takayama; Kamal Dua; Murtaza M Tambuwala
        Materials letters, 2021年12月01日
      • Protective Face Masks: Current Status and Future Trends.
        Alberto Tuñón-Molina; Kazuo Takayama; Elrashdy M Redwan; Vladimir N Uversky; Juan Andrés; Ángel Serrano-Aroca
        ACS applied materials & interfaces, 2021年11月19日
      • Generation of Tetrafluoroethylene-Propylene Elastomer-Based Microfluidic Devices for Drug Toxicity and Metabolism Studies.
        Emi Sano; Sayaka Deguchi; Naoki Matsuoka; Masahiro Tsuda; Mengyang Wang; Kaori Kosugi; Chihiro Mori; Keisuke Yagi; Aya Wada; Shinsuke Yamasaki; Tsuyoshi Kawai; Masahide Yodogawa; Hiroyuki Mizuguchi; Norihito Nakazawa; Fumiyoshi Yamashita; Yu-Suke Torisawa; Kazuo Takayama
        ACS omega, 2021年09月28日
      • Potential Molecular Mechanisms of Rare Anti-Tumor Immune Response by SARS-CoV-2 in Isolated Cases of Lymphomas.
        Debmalya Barh; Sandeep Tiwari; Lucas Gabriel Rodrigues Gomes; Marianna E Weener; Khalid J Alzahrani; Khalaf F Alsharif; Alaa A A Aljabali; Murtaza M Tambuwala; Kenneth Lundstrom; Sk Sarif Hassan; Ángel Serrano-Aroca; Kazuo Takayama; Preetam Ghosh; Elrashdy M Redwan; Bruno Silva Andrade; Siomar de Castro Soares; Vasco Azevedo; Vladimir N Uversky
        Viruses, 2021年09月25日
      • Implications derived from S-protein variants of SARS-CoV-2 from six continents.
        Sk Sarif Hassan; Kenneth Lundstrom; Debmalya Barh; Raner Jośe Santana Silva; Bruno Silva Andrade; Vasco Azevedo; Pabitra Pal Choudhury; Giorgio Palu; Bruce D Uhal; Ramesh Kandimalla; Murat Seyran; Amos Lal; Samendra P Sherchan; Gajendra Kumar Azad; Alaa A A Aljabali; Adam M Brufsky; Ángel Serrano-Aroca; Parise Adadi; Tarek Mohamed Abd El-Aziz; Elrashdy M Redwan; Kazuo Takayama; Nima Rezaei; Murtaza Tambuwala; Vladimir N Uversky
        International journal of biological macromolecules, 2021年09月24日
      • Periodically aperiodic pattern of SARS-CoV-2 mutations underpins the uncertainty of its origin and evolution.
        Sk Sarif Hassan; Pallab Basu; Elrashdy M Redwan; Kenneth Lundstrom; Pabitra Pal Choudhury; Angel Serrano-Aroca; Gajendra Kumar Azad; Alaa A A Aljabali; Giorgio Palu; Tarek Mohamed Abd El-Aziz; Debmalya Barh; Bruce D Uhal; Parise Adadi; Kazuo Takayama; Nicolas G Bazan; Murtaza Tambuwala; Amos Lal; Gaurav Chauhan; Wagner Baetas-da-Cruz; Samendra P Sherchan; Vladimir N Uversky
        Environmental research, 2021年09月22日
      • Antiviral Face Mask Functionalized with Solidified Hand Soap: Low-Cost Infection Prevention Clothing against Enveloped Viruses Such as SARS-CoV-2.
        Alba Cano-Vicent; Alberto Tuñón-Molina; Miguel Martí; Yukiko Muramoto; Takeshi Noda; Kazuo Takayama; Ángel Serrano-Aroca
        ACS omega, 2021年09月14日
      • Autoimmunity roots of the thrombotic events after COVID-19 vaccination.
        Fatma Elrashdy; Murtaza M Tambuwala; Sk Sarif Hassan; Parise Adadi; Murat Seyran; Tarek Mohamed Abd El-Aziz; Nima Rezaei; Amos Lal; Alaa A A Aljabali; Ramesh Kandimalla; Nicolas G Bazan; Gajendra Kumar Azad; Samendra P Sherchan; Pabitra Pal Choudhury; Ángel Serrano-Aroca; Kazuo Takayama; Gaurav Chauhan; Damiano Pizzol; Debmalya Barh; Pritam Kumar Panda; Yogendra K Mishra; Giorgio Palù; Kenneth Lundstrom; Elrashdy M Redwan; Vladimir N Uversky
        Autoimmunity reviews, 2021年09月09日
      • Antimicrobial Face Shield: Next Generation of Facial Protective Equipment against SARS-CoV-2 and Multidrug-Resistant Bacteria.
        Alberto Tuñón-Molina; Miguel Martí; Yukiko Muramoto; Takeshi Noda; Kazuo Takayama; Ángel Serrano-Aroca
        International journal of molecular sciences, 2021年09月01日
      • Usability of Polydimethylsiloxane-Based Microfluidic Devices in Pharmaceutical Research Using Human Hepatocytes.
        Sayaka Deguchi; Masahiro Tsuda; Kaori Kosugi; Ayaka Sakamoto; Natsumi Mimura; Ryosuke Negoro; Emi Sano; Takuro Nobe; Kazuya Maeda; Hiroyuki Kusuhara; Hiroyuki Mizuguchi; Fumiyoshi Yamashita; Yu-Suke Torisawa; Kazuo Takayama
        ACS biomaterials science & engineering, 2021年08月09日
      • In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology.
        Sayaka Deguchi; Tomohiro Shintani; Kazuo Harada; Toru Okamoto; Akinori Takemura; Kazumasa Hirata; Kousei Ito; Kazuo Takayama; Hiroyuki Mizuguchi
        Hepatology communications, 2021年08月
      • SARS-CoV-2 research using human pluripotent stem cells and organoids.
        Sayaka Deguchi; Ángel Serrano-Aroca; Murtaza M Tambuwala; Bruce D Uhal; Adam M Brufsky; Kazuo Takayama
        Stem cells translational medicine, 2021年07月24日
      • The mechanism behind flaring/triggering of autoimmunity disorders associated with COVID-19.
        Elrashdy M Redwan; Mohammed F Alghamdi; Tarek Mohamed Abd El-Aziz; Parise Adadi; Alaa A A Aljabali; Diksha Attrish; Gajendra Kumar Azad; Wagner Baetas-da-Cruz; Debmalya Barh; Nicolas G Bazan; Adam M Brufsky; Gaurav Chauhan; S K Sarif Hassan; Ramesh Kandimalla; Amos Lal; Kenneth Lundstrom; Yogendra Kumar Mishra; Pabitra Pal Choudhury; Giorgio Palù; Pritam K Panda; Damiano Pizzol; Nima Rezaei; Ángel Serrano-Aroca; Samendra P Sherchan; Murat Seyran; Kazuo Takayama; Murtaza M Tambuwala; Bruce D Uhal; Vladimir N Uversky
        Autoimmunity reviews, 2021年07月16日
      • Targeting LIN28: a new hope in prostate cancer theranostics.
        Garima Shrivastava; Alaa Aa Aljabali; Seyed Hossein Shahcheraghi; Marzieh Lotfi; Madhur D Shastri; Shakti D Shukla; Dinesh K Chellappan; Niraj Kumar Jha; Krishnan Anand; Harish Dureja; Ritesh M Pabari; Vijay Mishra; Abdulmajeed G Almutary; Abdullah M Alnuqaydan; Nitin Charbe; Parteek Prasher; Poonam Negi; Rohit Goyal; Kamal Dua; Gaurav Gupta; Ángel Serrano-Aroca; Bojlul Bahar; Debmalya Barh; Pritam Kumar Panda; Kazuo Takayama; Kenneth Lundstrom; Paul McCarron; Hamid Bakshi; Murtaza M Tambuwala
        Future oncology (London, England), 2021年07月15日
      • COVID-19 Vaccines and Thrombosis-Roadblock or Dead-End Street?
        Kenneth Lundstrom; Debmalya Barh; Bruce D Uhal; Kazuo Takayama; Alaa A A Aljabali; Tarek Mohamed Abd El-Aziz; Amos Lal; Elrashdy M Redwan; Parise Adadi; Gaurav Chauhan; Samendra P Sherchan; Gajendra Kumar Azad; Nima Rezaei; Ángel Serrano-Aroca; Nicolas G Bazan; Sk Sarif Hassan; Pritam Kumar Panda; Pabitra Pal Choudhury; Damiano Pizzol; Ramesh Kandimalla; Wagner Baetas-da-Cruz; Yogendra Kumar Mishra; Giorgio Palu; Adam M Brufsky; Murtaza M Tambuwala; Vladimir N Uversky
        Biomolecules, 2021年07月13日
      • Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system.
        Moe Ichikawa; Hiroki Akamine; Michika Murata; Sumito Ito; Kazuo Takayama; Hiroyuki Mizuguchi
        Scientific reports, 2021年06月03日
      • A unique view of SARS-CoV-2 through the lens of ORF8 protein.
        Sk Sarif Hassan; Alaa A A Aljabali; Pritam Kumar Panda; Shinjini Ghosh; Diksha Attrish; Pabitra Pal Choudhury; Murat Seyran; Damiano Pizzol; Parise Adadi; Tarek Mohamed Abd El-Aziz; Antonio Soares; Ramesh Kandimalla; Kenneth Lundstrom; Amos Lal; Gajendra Kumar Azad; Vladimir N Uversky; Samendra P Sherchan; Wagner Baetas-da-Cruz; Bruce D Uhal; Nima Rezaei; Gaurav Chauhan; Debmalya Barh; Elrashdy M Redwan; Guy W Dayhoff 2nd; Nicolas G Bazan; Ángel Serrano-Aroca; Amr El-Demerdash; Yogendra K Mishra; Giorgio Palu; Kazuo Takayama; Adam M Brufsky; Murtaza M Tambuwala
        Computers in biology and medicine, 2021年06月
      • Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial-Resistant Era.
        Ángel Serrano-Aroca; Kazuo Takayama; Alberto Tuñón-Molina; Murat Seyran; Sk Sarif Hassan; Pabitra Pal Choudhury; Vladimir N Uversky; Kenneth Lundstrom; Parise Adadi; Giorgio Palù; Alaa A A Aljabali; Gaurav Chauhan; Ramesh Kandimalla; Murtaza M Tambuwala; Amos Lal; Tarek Mohamed Abd El-Aziz; Samendra Sherchan; Debmalya Barh; Elrashdy M Redwan; Nicolas G Bazan; Yogendra Kumar Mishra; Bruce D Uhal; Adam Brufsky
        ACS nano, 2021年05月25日
      • Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells.
        Emi Sano; Sayaka Deguchi; Ayaka Sakamoto; Natsumi Mimura; Ai Hirabayashi; Yukiko Muramoto; Takeshi Noda; Takuya Yamamoto; Kazuo Takayama
        iScience, 2021年05月21日
      • Overview of key molecular and pharmacological targets for diabetes and associated diseases.
        Seyed Hossein Shahcheraghi; Alaa A A Aljabali; Mazhar S Al Zoubi; Vijay Mishra; Nitin B Charbe; Yusuf A Haggag; Garima Shrivastava; Abdulmajeed G Almutary; Abdullah M Alnuqaydan; Debmalya Barh; Kamal Dua; Dinesh K Chellappan; Gaurav Gupta; Marzieh Lotfi; Ángel Serrano-Aroca; Bojlul Bahar; Yogendra Kumar Mishra; Kazuo Takayama; Pritam Kumar Panda; Hamid A Bakshi; Murtaza M Tambuwala
        Life sciences, 2021年05月18日
      • Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2.
        Sk Sarif Hassan; Diksha Attrish; Shinjini Ghosh; Pabitra Pal Choudhury; Vladimir N Uversky; Alaa A A Aljabali; Kenneth Lundstrom; Bruce D Uhal; Nima Rezaei; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza M Tambuwala; Gajendra Kumar Azad; Samendra P Sherchan; Wagner Baetas-da-Cruz; Amos Lal; Giorgio Palù; Kazuo Takayama; Ángel Serrano-Aroca; Debmalya Barh; Adam M Brufsky
        International journal of biological macromolecules, 2021年04月16日
      • Asymmetric profiles of infection and innate immunological responses in human iPS cell-derived small intestinal epithelial-like cell monolayers following infection with mammalian reovirus.
        Chieko Inoue; Ryosuke Negoro; Kazuo Takayama; Hiroyuki Mizuguchi; Fuminori Sakurai
        Virus research, 2021年04月15日
      • Vinblastine treatment decreases the undifferentiated cell contamination of human iPSC-derived intestinal epithelial-like cells.
        Moe Ichikawa; Ryosuke Negoro; Kanae Kawai; Tomoki Yamashita; Kazuo Takayama; Hiroyuki Mizuguchi
        Molecular therapy. Methods & clinical development, 2021年03月12日
      • In Vivo Gene Expression Profile of Human Intestinal Epithelial Cells: From the Viewpoint of Drug Metabolism and Pharmacokinetics.
        Kazuo Takayama; Kohei Ito; Akiko Matsui; Tomoki Yamashita; Kentaro Kawakami; Daisuke Hirayama; Wataru Kishimoto; Hiroshi Nakase; Hiroyuki Mizuguchi
        Drug metabolism and disposition: the biological fate of chemicals, 2021年03月
      • Protective Face Mask Filter Capable of Inactivating SARS-CoV-2, and Methicillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis.
        Miguel Martí; Alberto Tuñón-Molina; Finn Lillelund Aachmann; Yukiko Muramoto; Takeshi Noda; Kazuo Takayama; Ángel Serrano-Aroca
        Polymers, 2021年01月08日
      • Generation of Hepatocytes from Human ES/iPS Cells for Regenerative Medicine
        Tomoki Yamashita; Kazuo Takayama; Hiroyuki Mizuguchi
        Cell-Inspired Materials and Engineering, 2021年
      • Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features.
        Sk Sarif Hassan; Shinjini Ghosh; Diksha Attrish; Pabitra Pal Choudhury; Alaa A A Aljabali; Bruce D Uhal; Kenneth Lundstrom; Nima Rezaei; Vladimir N Uversky; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza M Tambuwala; Gajendra Kumar Azad; Samendra P Sherchan; Wagner Baetas-da-Cruz; Kazuo Takayama; Ángel Serrano-Aroca; Gaurav Chauhan; Giorgio Palu; Adam M Brufsky
        Molecules (Basel, Switzerland), 2020年12月13日
      • Introductions to the Community: Early-Career Researchers in the Time of COVID-19.
        Kazuo Takayama; Lesley N Weaver; Edroaldo Lummertz da Rocha; Valentina Lo Sardo; Helmuth Gehart; Ly P Vu
        Cell stem cell, 2020年12月03日
      • The structural basis of accelerated host cell entry by SARS-CoV-2†.
        Murat Seyran; Kazuo Takayama; Vladimir N Uversky; Kenneth Lundstrom; Giorgio Palù; Samendra P Sherchan; Diksha Attrish; Nima Rezaei; Alaa A A Aljabali; Shinjini Ghosh; Damiano Pizzol; Gaurav Chauhan; Parise Adadi; Tarek Mohamed Abd El-Aziz; Antonio G Soares; Ramesh Kandimalla; Murtaza Tambuwala; Sk Sarif Hassan; Gajendra Kumar Azad; Pabitra Pal Choudhury; Wagner Baetas-da-Cruz; Ángel Serrano-Aroca; Adam M Brufsky; Bruce D Uhal
        The FEBS journal, 2020年12月02日
      • Photoactivatable oncolytic adenovirus for optogenetic cancer therapy.
        Yasuko Hagihara; Ayaka Sakamoto; Takashi Tokuda; Tomoki Yamashita; Sena Ikemoto; Ayaka Kimura; Makito Haruta; Kiyotaka Sasagawa; Jun Ohta; Kazuo Takayama; Hiroyuki Mizuguchi
        Cell death & disease, 2020年07月23日
      • Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies.
        Kanae Kawai; Ryosuke Negoro; Moe Ichikawa; Tomoki Yamashita; Sayaka Deguchi; Kazuo Harada; Kazumasa Hirata; Kazuo Takayama; Hiroyuki Mizuguchi
        Molecular therapy. Methods & clinical development, 2020年06月12日, 査読有り
      • In Vitro and Animal Models for SARS-CoV-2 research.
        Kazuo Takayama
        Trends in pharmacological sciences, 2020年05月30日, 査読有り
      • Generation of human bronchial organoids for SARS-CoV-2 research
        Tatsuya Suzuki; Yumi Itoh; Yusuke Sakai; Akatsuki Saito; Daisuke Okuzaki; Daisuke Motooka; Shohei Minami; Takeshi Kobayashi; Takuya Yamamoto; Toru Okamoto; Kazuo Takayama
        2020年05月26日
      • Tolloid-Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling.
        Ayumi Kiso; Yukiko Toba; Susumu Tsutsumi; Sayaka Deguchi; Keisuke Igai; Saki Koshino; Yasuhito Tanaka; Kazuo Takayama; Hiroyuki Mizuguchi
        Hepatology communications, 2020年02月, 査読有り
      • Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance.
        Yukiko Toba; Sayaka Deguchi; Natsumi Mimura; Ayaka Sakamoto; Kazuo Harada; Kazumasa Hirata; Kazuo Takayama; Hiroyuki Mizuguchi
        PloS one, 2020年, 査読有り
      • Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells.
        Sayaka Deguchi; Tomoki Yamashita; Keisuke Igai; Kazuo Harada; Yukiko Toba; Kazumasa Hirata; Kazuo Takayama; Hiroyuki Mizuguchi
        Drug metabolism and disposition: the biological fate of chemicals, 2019年06月, 査読有り
      • FGF signal is not required for hepatoblast differentiation of human iPS cells.
        Yukiko Toba; Ayumi Kiso; Souichiro Nakamae; Fuminori Sakurai; Kazuo Takayama; Hiroyuki Mizuguchi
        Scientific reports, 2019年03月06日, 査読有り
      • Pharmaceutical Research for Inherited Metabolic Disorders of the Liver Using Human Induced Pluripotent Stem Cell and Genome Editing Technologies.
        Tomoki Yamashita; Kazuo Takayama; Mika Hori; Mariko Harada-Shiba; Hiroyuki Mizuguchi
        Biological & pharmaceutical bulletin, 2019年, 査読有り
      • Generation of Human iPSC-Derived Intestinal Epithelial Cell Monolayers by CDX2 Transduction.
        Takayama K; Negoro R; Yamashita T; Kawai K; Ichikawa M; Mori T; Nakatsu N; Harada K; Ito S; Yamada H; Yamaura Y; Hirata K; Ishida S; Mizuguchi H
        Cellular and molecular gastroenterology and hepatology, 2019年, 査読有り
      • [Pharmaceutical Research on Liver Diseases Using iPS Cell and Genome Editing Technologies].
        Takayama K
        Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2019年, 査読有り
      • Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies.
        Ryosuke Negoro; Kazuo Takayama; Kanae Kawai; Kazuo Harada; Fuminori Sakurai; Kazumasa Hirata; Hiroyuki Mizuguchi
        Stem cell reports, 2018年12月11日, 査読有り
      • Optimal human iPS cell culture method for efficient hepatic differentiation.
        Matoba N; Yamashita T; Takayama K; Sakurai F; Mizuguchi H
        Differentiation; research in biological diversity, 2018年09月, 査読有り
      • Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research.
        Kazuo Takayama; Yasuko Hagihara; Yukiko Toba; Kiyotoshi Sekiguchi; Fuminori Sakurai; Hiroyuki Mizuguchi
        Biomaterials, 2018年04月, 査読有り
      • Nanaomycin A Treatment Promotes Hepatoblast Differentiation from Human iPS Cells.
        Souichiro Nakamae; Yukiko Toba; Kazuo Takayama; Fuminori Sakurai; Hiroyuki Mizuguchi
        Stem cells and development, 2018年03月15日, 査読有り
      • Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells.
        Tomoki Yamashita; Kazuo Takayama; Fuminori Sakurai; Hiroyuki Mizuguchi
        Biochemical and biophysical research communications, 2018年02月19日, 査読有り
      • Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy.
        Kazuo Takayama; Hiroyuki Mizuguchi
        ACS chemical biology, 2018年02月16日, 査読有り
      • Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B.
        Ryota Okamoto; Kazuo Takayama; Naoki Akita; Yasuhito Nagamoto; Daiki Hosokawa; Shunsuke Iizuka; Fuminori Sakurai; Hiroshi Suemizu; Kazuo Ohashi; Hiroyuki Mizuguchi
        Cell transplantation, 2018年02月, 査読有り
      • Generation of safe and therapeutically effective human induced pluripotent stem cell-derived hepatocyte-like cells for regenerative medicine.
        Kazuo Takayama; Naoki Akita; Natsumi Mimura; Rina Akahira; Yukimasa Taniguchi; Makoto Ikeda; Fuminori Sakurai; Osamu Ohara; Tomohiro Morio; Kiyotoshi Sekiguchi; Hiroyuki Mizuguchi
        Hepatology communications, 2017年12月, 査読有り
      • y Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction
        Daiki Nakamori; Hiroki Akamine; Kazuo Takayama; Fuminori Sakurai; Hiroyuki Mizuguchi
        SCIENTIFIC REPORTS, 2017年11月, 査読有り
      • Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells
        Fuminori Sakurai; Takemaru Kunito; Kazuo Takayama; Rina Hashimoto; Masashi Tachibana; Naoya Sakamoto; Takaji Wakita; Hiroyuki Mizuguchi
        VIRUS RESEARCH, 2017年10月, 査読有り
      • Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation from Human Induced Pluripotent Stem Cells
        Morifumi Hanawa; Kazuo Takayama; Fuminori Sakurai; Masashi Tachibana; Hiroyuki Mizuguchi
        STEM CELL REVIEWS AND REPORTS, 2017年08月, 査読有り
      • Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling
        Seiji Mitani; Kazuo Takayama; Yasuhito Nagamoto; Kazuo Imagawa; Fuminori Sakurai; Masashi Tachibana; Ryo Sumazaki; Hiroyuki Mizuguchi
        MOLECULAR THERAPY, 2017年06月, 査読有り
      • Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system
        Kazuo Takayama; Keisuke Igai; Yasuko Hagihara; Rina Hashimoto; Morifumi Hanawa; Tetsushi Sakuma; Masashi Tachibana; Fuminori Sakurai; Takashi Yamamoto; Hiroyuki Mizuguchi
        NUCLEIC ACIDS RESEARCH, 2017年05月, 査読有り
      • Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection
        Fuminori Sakurai; Seiji Mitani; Tatsuro Yamamoto; Kazuo Takayama; Masashi Tachibana; Koichi Watashi; Takaji Wakita; Sayuki Iijima; Yasuhito Tanaka; Hiroyuki Mizuguchi
        SCIENTIFIC REPORTS, 2017年04月, 査読有り
      • Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions
        Takayuki Fukuda; Kazuo Takayama; Mitsuhi Hirata; Yu-Jung Liu; Kana Yanagihara; Mika Suga; Hiroyuki Mizuguchi; Miho K. Furue
        EXPERIMENTAL CELL RESEARCH, 2017年03月, 査読有り
      • Inhibition of CRISPR/Cas9-Mediated Genome Engineering by a Type I Interferon-Induced Reduction in Guide RNA Expression
        Mitsuhiro Machitani; Fuminori Sakurai; Keisaku Wakabayashi; Kosuke Nakatani; Kazuo Takayama; Masashi Tachibana; Hiroyuki Mizuguhi
        BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2017年03月, 査読有り
      • Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells
        Kazuo Imagawa; Kazuo Takayama; Shigemi Isoyama; Ken Tanikawa; Masato Shinkai; Kazuo Harada; Masashi Tachibana; Fuminori Sakurai; Emiko Noguchi; Kazumasa Hirata; Masayoshi Kage; Kenji Kawabata; Ryo Sumazaki; Hiroyuki Mizuguchi
        Scientific Reports, 2017年02月, 査読有り
      • Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening
        Kazuo Takayama; Hiroyuki Mizuguchi
        DRUG METABOLISM AND PHARMACOKINETICS, 2017年02月, 査読有り
      • Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells
        Kana Yanagihara; Yujung Liu; Kei Kanie; Kazuo Takayama; Minako Kokunugi; Mitsuhi Hirata; Takayuki Fukuda; Mika Suga; Hiroki Nikawa; Hiroyuki Mizuguchi; Ryuji Kato; Miho K. Furue
        STEM CELLS AND DEVELOPMENT, 2016年12月, 査読有り
      • Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure
        Yasuhito Nagamoto; Kazuo Takayama; Kazuo Ohashi; Ryota Okamoto; Fuminori Sakurai; Masashi Tachibana; Kenji Kawabata; Hiroyuki Mizuguchi
        JOURNAL OF HEPATOLOGY, 2016年05月, 査読有り
      • Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells
        Kazuo Takayama; Seiji Mitani; Yasuhito Nagamoto; Fuminori Sakurai; Masashi Tachibana; Yukimasa Taniguchi; Kiyotoshi Sekiguchi; Hiroyuki Mizuguchi
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016年05月, 査読有り
      • Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cellst
        Ryosuke Negoro; Kazuo Takayama; Yasuhito Nagamoto; Fuminori Sakurai; Masashi Tachibana; Hiroyuki Mizuguchi
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016年04月, 査読有り
      • Hepatic Maturation of Human iPS Cell-Derived Hepatocyte-Like Cells by ATF5, c/EBPα, and PROX1 Transduction
        Nakamori D; Takayama K; co-first author; Nagamoto Y; Mitani S; Sakurai F; Tachibana M; Mizuguchi H
        Biochem Biophys Res Commun., 2016年01月, 査読有り
      • Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine
        Tatsuya Ozawa; Kazuo Takayama; Ryota Okamoto; Ryosuke Negoro; Fuminori Sakurai; Masashi Tachibana; Kenji Kawabata; Hiroyuki Mizuguchi
        SCIENTIFIC REPORTS, 2015年11月, 査読有り
      • Establishment of a Method of Hepatocyte Differentiation from Human Pluripotent Stem Cells for Innovative Drug Development
        Kazuo Takayama
        YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2015年10月, 査読有り
      • Generation of Brain Microvascular Endothelial-Like Cells from Human Induced Pluripotent Stem Cells by Co-Culture with C6 Glioma Cells
        Haruka Minami; Katsuhisa Tashiro; Atsumasa Okada; Nobue Hirata; Tomoko Yamaguchi; Kazuo Takayama; Hiroyuki Mizuguchi; Kenji Kawabata
        PLOS ONE, 2015年06月, 査読有り
      • Expression of Coxsackievirus and Adenovirus Receptor Separates Hematopoietic and Cardiac Progenitor Cells in Fetal Liver Kinase 1-Expressing Mesoderm
        Katsuhisa Tashiro; Nobue Hirata; Atsumasa Okada; Tomoko Yamaguchi; Kazuo Takayama; Hiroyuki Mizuguchi; Kenji Kawabata
        STEM CELLS TRANSLATIONAL MEDICINE, 2015年05月, 査読有り
      • Expression of Coxsackievirus and Adenovirus Receptor Separates Hematopoietic and Cardiac Progenitor Cells in Fetal Liver Kinase 1-Expressing Mesoderm
        Katsuhisa Tashiro; Nobue Hirata; Atsumasa Okada; Tomoko Yamaguchi; Kazuo Takayama; Hiroyuki Mizuguchi; Kenji Kawabata
        STEM CELLS TRANSLATIONAL MEDICINE, 2015年05月, 査読有り
      • Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene
        Yasuhito Nagamoto; Kazuo Takayama; Katsuhisa Tashiro; Chise Tateno; Fuminori Sakurai; Masashi Tachibana; Kenji Kawabata; Kazuo Ikeda; Yasuhito Tanaka; Hiroyuki Mizuguchi
        CELL TRANSPLANTATION, 2015年, 査読有り
      • Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene
        Yasuhito Nagamoto; Kazuo Takayama; Katsuhisa Tashiro; Chise Tateno; Fuminori Sakurai; Masashi Tachibana; Kenji Kawabata; Kazuo Ikeda; Yasuhito Tanaka; Hiroyuki Mizuguchi
        CELL TRANSPLANTATION, 2015年, 査読有り
      • Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes
        Kazuo Takayama; Yuta Morisaki; Shuichi Kuno; Yasuhito Nagamoto; Kazuo Harada; Norihisa Furukawa; Manami Ohtaka; Ken Nishimura; Kazuo Imagawa; Fuminori Sakurai; Masashi Tachibana; Ryo Sumazaki; Emiko Noguchi; Mahito Nakanishi; Kazumasa Hirata; Kenji Kawabata; Hiroyuki Mizuguchi
        PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014年11月, 査読有り
      • HHEX Promotes Hepatic-Lineage Specification through the Negative Regulation of Eomesodermin
        Hitoshi Watanabe; Kazuo Takayama; Mitsuru Inamura; Masashi Tachibana; Natsumi Mimura; Kazufumi Katayama; Katsuhisa Tashiro; Yasuhito Nagamoto; Fuminori Sakurai; Kenji Kawabata; Miho Kusuda Furue; Hiroyuki Mizuguchi
        PLOS ONE, 2014年03月, 査読有り
      • CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determines the hepatoblast fate decision.
        Takayama K; Kawabata K; Nagamoto Y; Inamura M; Ohashi K; Okuno H; Yamaguchi T; Tashiro K; Sakurai F; Hayakawa T; Okano T; Furue MK; Mizuguchi H
        Development (Cambridge, England), 2014年01月, 査読有り
      • CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determine the hepatoblast fate decision
        Takayama K; Kawabata K; Nagamoto Y; Inamura M; Ohashi K; Okuno H; Yamaguchi T; Tashiro K; Sakurai F; Hayakawa T; Okano T; Furue MK; Mizuguchi H
        Development, 2014年01月, 査読有り
      • Long-Term Self-Renewal of Human ES/iPS-Derived Hepatoblast-like Cells on Human Laminin 111-Coated Dishes
        Kazuo Takayama; Yasuhito Nagamoto; Natsumi Mimura; Katsuhisa Tashiro; Fuminori Sakurai; Masashi Tachibana; Takao Hayakawa; Kenji Kawabata; Hiroyuki Mizuguchi
        STEM CELL REPORTS, 2013年10月, 査読有り
      • 3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing.
        Kazuo Takayama; Kenji Kawabata; Yasuhito Nagamoto; Keisuke Kishimoto; Katsuhisa Tashiro; Fuminori Sakurai; Masashi Tachibana; Katsuhiro Kanda; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi
        Biomaterials, 2013年02月, 査読有り
      • Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction.
        Takayama K; Inamura M; Kawabata K; Sugawara M; Kikuchi K; Higuchi M; Nagamoto Y; Watanabe H; Tashiro K; Sakurai F; Hayakawa T; Furue MK; Mizuguchi H
        Journal of Hepatology, 2012年09月, 査読有り
      • The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets
        Yasuhito Nagamoto; Katsuhisa Tashiro; Kazuo Takayama; Kazuo Ohashi; Kenji Kawabata; Fuminori Sakurai; Masashi Tachibana; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi
        BIOMATERIALS, 2012年06月, 査読有り
      • Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction.
        Takayama K; Inamura M; Kawabata K; Katayama K; Higuchi M; Tashiro K; Nonaka A; Sakurai F; Hayakawa T; Furue MK; Mizuguchi H
        Molecular therapy : the journal of the American Society of Gene Therapy, 2012年01月, 査読有り
      • Efficient generation of functional hepatocytes from human embryonic stem cells and induced cells by HNF4α transduction
        Takayama K; Inamura M; Kawabata K; Katayama K; Higuchi M; Tashiro K; Nonaka A; Sakurai F; Hayakawa T; Furue MK; Mizuguchi H
        Mol Ther., 2012年01月, 査読有り
      • Endodermal and Hepatic Differentiation from Human Embryonic Stem Cells and Human Induced Pluripotent Stem Cells.
        Kawabata K; Takayama K; Nagamoto Y; Saldon M.S; Higuchi M; Mizuguchi H
        J Stem Cell Res Ther., 2012年, 査読有り
      • Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection
        Takeshi Yoshida; Kazuo Takayama; Masuo Kondoh; Fuminori Sakurai; Hideki Tani; Naoya Sakamoto; Yoshiharu Matsuura; Hiroyuki Mizuguchi; Kiyohito Yagi
        BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011年12月, 査読有り
      • Efficient and Directive Generation of Two Distinct Endoderm Lineages from Human ESCs and iPSCs by Differentiation Stage-Specific SOX17 Transduction
        Kazuo Takayama; Mitsuru Inamura; Kenji Kawabata; Katsuhisa Tashiro; Kazufumi Katayama; Fuminori Sakurai; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi
        PLOS ONE, 2011年07月, 査読有り
      • Efficient Generation of Hepatoblasts From Human ES Cells and iPS Cells by Transient Overexpression of Homeobox Gene HEX
        Mitsuru Inamura; Kenji Kawabata; Kazuo Takayama; Katsuhisa Tashiro; Fuminori Sakurai; Kazufumi Katayama; Masashi Toyoda; Hidenori Akutsu; Yoshitaka Miyagawa; Hajime Okita; Nobutaka Kiyokawa; Akihiro Umezawa; Takao Hayakawa; Miho K. Furue; Hiroyuki Mizuguchi
        MOLECULAR THERAPY, 2011年02月, 査読有り
      • Adenovirus Vector-Mediated Efficient Transduction into Human Embryonic and Induced Pluripotent Stem Cells
        Katsuhisa Tashiro; Kenji Kawabata; Mitsuru Inamura; Kazuo Takayama; Norihisa Furukawa; Fuminori Sakurai; Kazufumi Katayama; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi
        CELLULAR REPROGRAMMING, 2010年10月, 査読有り
      • The importance of accessory protein variants in the pathogenicity of SARS-CoV-2.
        Sk Sarif Hassan; Pabitra Pal Choudhury; Guy W Dayhoff 2nd; Alaa A A Aljabali; Bruce D Uhal; Kenneth Lundstrom; Nima Rezaei; Damiano Pizzol; Parise Adadi; Amos Lal; Antonio Soares; Tarek Mohamed Abd El-Aziz; Adam M Brufsky; Gajendra Kumar Azad; Samendra P Sherchan; Wagner Baetas-da-Cruz; Kazuo Takayama; Ãngel Serrano-Aroca; Gaurav Chauhan; Giorgio Palu; Yogendra Kumar Mishra; Debmalya Barh; Raner Jośe Santana Silva; Bruno Silva Andrade; Vasco Azevedo; Aristóteles Góes-Neto; Nicolas G Bazan; Elrashdy M Redwan; Murtaza Tambuwala; Vladimir N Uversky
        Archives of biochemistry and biophysics, 2022年03月15日
      • Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening.
        Tomohisa Tanaka; Akatsuki Saito; Tatsuya Suzuki; Yoichi Miyamoto; Kazuo Takayama; Toru Okamoto; Kohji Moriishi
        Antiviral research, 2022年03月07日
      • Gene Therapy for Neuropsychiatric Disorders: Potential Targets and Tools.
        Seyed Hossein Shahcheraghi; Jamshid Ayatollahi; Marzieh Lotfi; Alaa A A Aljabali; Mazhar S Al-Zoubi; Pritam Kumar Panda; Vijay Mishra; Saurabh Satija; Nitin B Charbe; Ángel Serrano-Aroca; Bojlul Bahar; Kazuo Takayama; Rohit Goyal; Amit Bhatia; Abdulmajeed G Almutary; Abdullah M Alnuqaydan; Yachana Mishra; Poonam Negi; Aaron Courtney; Paul A McCarron; Hamid A Bakshi; Murtaza M Tambuwala
        CNS & neurological disorders drug targets, 2022年03月04日
      • Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function.
        Sk Sarif Hassan; Kenneth Lundstrom; Ángel Serrano-Aroca; Parise Adadi; Alaa A A Aljabali; Elrashdy M Redwan; Amos Lal; Ramesh Kandimalla; Tarek Mohamed Abd El-Aziz; Pabitra Pal Choudhury; Gajendra Kumar Azad; Samendra P Sherchan; Gaurav Chauhan; Murtaza Tambuwala; Kazuo Takayama; Debmalya Barh; Giorgio Palu; Pallab Basu; Vladimir N Uversky
        International journal of biological macromolecules, 2022年01月01日
      • Non-Woven Infection Prevention Fabrics Coated with Biobased Cranberry Extracts Inactivate Enveloped Viruses Such as SARS-CoV-2 and Multidrug-Resistant Bacteria.
        Kazuo Takayama; Alberto Tuñón-Molina; Alba Cano-Vicent; Yukiko Muramoto; Takeshi Noda; José Luis Aparicio-Collado; Roser Sabater I Serra; Miguel Martí; Ángel Serrano-Aroca
        International journal of molecular sciences, 2021年11月24日

      MISC

      • 創薬応用を目指したヒトiPS細胞由来小腸上皮細胞の作製
        高山 和雄; 水口 裕之
        バイオサイエンスとインダストリー, 2016年
      • ヒトiPS細胞から肝細胞への分化誘導の現状と創薬応用
        水口 裕之; 高山 和雄; 長基 康人
        医薬品医療機器レギュラトリーサイエンス, 2012年
      • Establishment of MDR1-knockout human induced pluripotent stem cell line.
        Ryosuke Negoro; Kanae Kawai; Moe Ichikawa; Sayaka Deguchi; Kazuo Takayama; Hiroyuki Mizuguchi
        Drug metabolism and pharmacokinetics, 2020年02月10日
      • Generation of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells for Cellular Medicine.
        Sayaka Deguchi; Kazuo Takayama; Hiroyuki Mizuguchi
        Biological & pharmaceutical bulletin, 2020年, 査読有り
      • 再生医療への応用を見据えた臨床グレートのヒトiPS細胞由来肝細胞の作製
        高山 和雄; 萩原 康子; 関口 清俊; 森尾 友宏; 小原 收; 立花 雅史; 櫻井 文教; 水口 裕之
        日本生化学会大会・日本分子生物学会年会合同大会講演要旨集, 2015年12月
      • Human iPSC-derived hepatocyte-like cells generated from patients with bile salt export pump deficiency recapitulate the phenotype of progressive familial intrahepatic cholestasis type 2
        Kazuo Imagawa; Kazuo Takayama; Shigemi Isoyama; Ken Tanikawa; Masato Shinkai; Masayoshi Kage; Kenji Kawabata; Ryo Sumazaki; Hiroyuki Mizuguchi
        HEPATOLOGY, 2015年10月
      • ヒトES/iPS細胞から肝細胞への高効率分化誘導法の開発とその創薬応用
        高山 和雄; 川端 健二; 水口 裕之
        最新医学, 2013年01月
      • ヒトiPS細胞由来分化誘導肝細胞を用いた薬物毒性評価系の開発 (特集 ハイスループットな創薬スクリーニングを目指して)
        川端 健二; 高山 和雄; 水口 裕之
        Bio industry, 2013年01月
      • Human iPS-derived hepatocyte-like cells as a model for hepatitis C virus infection
        Seiji Yamane; Takeshi Yoshida; Kazuo Takayama; Masuo Kondoh; Fuminori Sakurai; Hiroyuki Mizuguchi; Kiyohito Yagi
        FASEB JOURNAL, 2012年04月

      産業財産権

      • 特開2017-018026, 特願2015-137995, 多能性幹細胞の遺伝子ターゲティング方法
        水口 裕之; 高山 和雄
      • 特許第5970245号, 特開2013-252081, 特願2012-128872, 幹細胞から肝細胞への分化誘導方法
        水口 裕之; 川端 健二; 高山 和雄
      • 特開2016-010379, 特願2014-134701, 薬物評価用細胞及び薬物評価方法
        水口 裕之; 高山 和雄
      • 特開2013-252081, 特願2012-128872, 幹細胞から肝細胞への分化誘導方法
        水口 裕之; 川端 健二; 高山 和雄

      外部資金:科学研究費補助金

      • 呼吸器疾患における基底細胞の役割解明
        基盤研究(B)
        小区分90110:生体医工学関連
        京都大学
        高山 和雄
        自 2021年04月01日, 至 2024年03月31日, 交付
        基底細胞;気管支;呼吸器感染症;iPS細胞;SARS-CoV-2
      • 光遺伝学的手法による局所的に出現した変異細胞の炎症細胞社会における意義解明
        新学術領域研究(研究領域提案型)
        大阪大学
        高山 和雄
        自 2018年04月01日, 至 2020年03月31日, 完了
        光操作;腸管上皮細胞;慢性炎症;腸炎;光遺伝学;ゲノム編集;1細胞;大腸がん;幹細胞
      • 肝障害・肝疾患研究に資するzone特異的肝細胞の創出技術の開発
        挑戦的研究(萌芽)
        大阪大学
        高山 和雄
        自 2017年06月30日, 至 2019年03月31日, 完了
        肝細胞;毒性;薬物代謝;zonation;ヒトiPS細胞;ヒトES細胞;肝障害;胆管上皮細胞;創薬;異物代謝;分化誘導;肝臓;ヒトES/iPS細胞
      • 創薬応用を目指した高純度CYP3A4発現ヒトES/iPS由来肝細胞の作製法の開発
        研究活動スタート支援
        大阪大学
        高山 和雄
        自 2015年08月28日, 至 2017年03月31日, 完了
        肝細胞;ヒトES/iPS細胞;薬物代謝;CYP;肝毒性;創薬試験;CYP3A4;ゲノム編集;薬物代謝酵素;相同組換え

      外部資金:その他

      • SARS-CoV-2の生活環を再現できるヒト肺モデルの開発と創薬応用 (2020年度分)
        京都発革新的医療技術研究開発助成事業
        自 2020年04月01日, 至 2021年03月31日
        高山 和雄

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