基本情報

所属学協会

• 日本動物実験代替法学会
• 日本ウイルス学会

学位

• 修士（薬科学）(大阪大学)
• 博士（薬科学）(大阪大学)

経歴

• 自 2020年03月, 至 現在

  京都大学iPS細胞研究所, 講師
• 自 2016年10月, 至 2020年03月

  さきがけ研究者
• 自 2018年02月, 至 2020年02月

  大阪大学大学院薬学研究科, 分子生物学分野, 助教
• 自 2015年04月, 至 2018年01月

  大阪大学大学院薬学研究科附属創薬センター, Graduate School of Pharmaceutical Sciences, Drug Innovation Center, 特任助教
• 自 2015年11月, 至 2017年03月

  K-CONNEX研究者

使用言語

• 日本語
• 英語

ID,URL

• ORCID ID

  0000-0002-1132-2457

• J-Global ID

  201601014824797050

• 研究者番号

  10759509

researchmap URL

• https://researchmap.jp/kazu0

研究

研究キーワード

• ウイルス
• オルガノイド
• 感染症
• 臓器チップ
• iPS細胞
• 多能性幹細胞
• 創薬

研究分野

• ライフサイエンス, 医療薬学

論文

• Anti-SARS-CoV-2 gapmer antisense oligonucleotides targeting the main protease region of viral RNA.

  Masako Yamasaki; Wakana Saso; Takuya Yamamoto; Masayoshi Sato; Hiroko Takagi; Tetsuya Hasegawa; Yuji Kozakura; Hiroyuki Yokoi; Hirofumi Ohashi; Kana Tsuchimoto; Rina Hashimoto; Shuetsu Fukushi; Akihiko Uda; Masamichi Muramatsu; Kazuo Takayama; Ken Maeda; Yoshimasa Takahashi; Tsuyoshi Nagase; Koichi Watashi

  Antiviral research, 2024年08月23日

  
• Refining Hepatocyte Models to Capture the Impact of CYP2D6*10 Utilizing a PITCh System.

  Ryosuke Negoro; Ayu Ouchi; Sayaka Deguchi; Kazuo Takayama; Takuya Fujita

  Biological & pharmaceutical bulletin, 2024年

  
• Perfluoropolyether-Based Gut-Liver-on-a-Chip for the Evaluation of First-Pass Metabolism and Oral Bioavailability of Drugs

  Mengyang Wang; Yuko Sasaki; Rena Sakagami; Tomotaka Minamikawa; Masahiro Tsuda; Ryohei Ueno; Sayaka Deguchi; Ryosuke Negoro; Kanako So; Yuriko Higuchi; Ryuji Yokokawa; Kazuo Takayama; Fumiyoshi Yamashita

  ACS Biomaterials Science and Engineering, 2024年

  
• Establishment of MDR1-knockout human induced pluripotent stem cell line.

  Negoro R; Kawai K; Ichikawa M; Deguchi S; Takayama K; Mizuguchi H

  Drug metabolism and pharmacokinetics, 2020年02月

  
• Generation of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells for Cellular Medicine.

  Deguchi S; Takayama K; Mizuguchi H

  Biological & pharmaceutical bulletin, 2020年01月

  
• 進行性家族性胆汁うっ滞症2型の疾患特異的iPS細胞を用いた研究

  今川 和生; 高山 和雄; 磯山 茂美; 野口 恵美子; 新開 真人; 立花 雅史; 櫻井 文教; 川端 健二; 須磨崎 亮; 水口 裕之

  日本小児科学会雑誌, 2015年02月

  
• Construction of multilayered small intestine-like tissue by reproducing interstitial flow

  Sayaka Deguchi; Kaori Kosugi; Naoki Takeishi; Yukio Watanabe; Shiho Morimoto; Ryosuke Negoro; Fuki Yokoi; Hiroki Futatsusako; May Nakajima-Koyama; Mio Iwasaki; Takuya Yamamoto; Yoshiya Kawaguchi; Yu-suke Torisawa; Kazuo Takayama

  Cell Stem Cell, 2024年07月

  
• Endothelial ROBO4 suppresses PTGS2/COX-2 expression and inflammatory diseases.

  Masato Tanaka; Keisuke Shirakura; Yui Takayama; Miki Μatsui; Yukio Watanabe; Takuya Yamamoto; Junya Takahashi; Shota Tanaka; Nobumasa Hino; Takefumi Doi; Masanori Obana; Yasushi Fujio; Kazuo Takayama; Yoshiaki Okada

  Communications biology, 2024年05月18日

  
• Virological characteristics of a SARS-CoV-2-related bat coronavirus, BANAL-20-236

  Shigeru Fujita; Arnon Plianchaisuk; Sayaka Deguchi; Hayato Ito; Naganori Nao; Lei Wang; Hesham Nasser; Tomokazu Tamura; Izumi Kimura; Yukie Kashima; Rigel Suzuki; Saori Suzuki; Izumi Kida; Masumi Tsuda; Yoshitaka Oda; Rina Hashimoto; Yukio Watanabe; Keiya Uriu; Daichi Yamasoba; Ziyi Guo; Alfredo A. Hinay; Yusuke Kosugi; Luo Chen; Lin Pan; Yu Kaku; Hin Chu; Flora Donati; Sarah Temmam; Marc Eloit; Yuki Yamamoto; Tetsuharu Nagamoto; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Yutaka Suzuki; Hirofumi Sawa; Keita Mizuma; Jingshu Li; Yume Mimura; Yuma Ohari; Tomoya Tsubo; Zannatul Ferdous; Kenji Shishido; Hiromi Mohri; Miki Iida; Shuhei Tsujino; Naoko Misawa; Kaoru Usui; Wilaiporn Saikruang; Spyridon Lytras; Shusuke Kawakubo; Luca Nishumura; Jarel Elgin Mendoza Tolentino; Wenye Li; Maximilian Stanley Yo; Kio Horinaka; Mai Suganami; Mika Chiba; Ryo Yoshimura; Kyoko Yasuda; Keiko Iida; Adam Patrick Strange; Naomi Ohsumi; Shiho Tanaka; Eiko Ogawa; Kaho Okumura; Tsuki Fukuda; Rina Osujo; Isao Yoshida; So Nakagawa; Akifumi Takaori-Kondo; Kotaro Shirakawa; Kayoko Nagata; Ryosuke Nomura; Yoshihito Horisawa; Yusuke Tashiro; Yugo Kawai; Yoshitaka Nakata; Hiroki Futatsusako; Ayaka Sakamoto; Naoko Yasuhara; Takao Hashiguchi; Tateki Suzuki; Kanako Kimura; Jiei Sasaki; Yukari Nakajima; Hisano Yajima; Takashi Irie; Ryoko Kawabata; Kaori Sasaki-Tabata; Ryo Shimizu; M.S.T. Monira Begum; Michael Jonathan; Yuka Mugita; Sharee Leong; Otowa Takahashi; Kimiko Ichihara; Takamasa Ueno; Chihiro Motozono; Mako Toyoda; Akatsuki Saito; Anon Kosaka; Miki Kawano; Natsumi Matsubara; Tomoko Nishiuchi; Jiri Zahradnik; Prokopios Andrikopoulos; Miguel Padilla-Blanco; Aditi Konar; Jumpei Ito; Terumasa Ikeda; Shinya Tanaka; Keita Matsuno; Takasuke Fukuhara; Kazuo Takayama; Kei Sato

  eBioMedicine, 2024年06月

  
• Longitudinal analysis of genomic mutations in SARS-CoV-2 isolates from persistent COVID-19 patient.

  Hiroki Futatsusako; Rina Hashimoto; Masaki Yamamoto; Jumpei Ito; Yasufumi Matsumura; Hajime Yoshifuji; Kotaro Shirakawa; Akifumi Takaori-Kondo; Kei Sato; Miki Nagao; Kazuo Takayama

  iScience, 2024年05月17日

  
• Micro-patterned culture of iPSC-derived alveolar and airway cells distinguishes SARS-CoV-2 variants.

  Atsushi Masui; Rina Hashimoto; Yasufumi Matsumura; Takuya Yamamoto; Miki Nagao; Takeshi Noda; Kazuo Takayama; Shimpei Gotoh

  Stem cell reports, 2024年04月09日

  この論文にアクセスする：

  
• A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT).

  Kenjiro Hanaoka; Takayuki Ikeno; Shimpei Iwaki; Sayaka Deguchi; Kazuo Takayama; Hiroyuki Mizuguchi; Fumiya Tao; Nobuhiko Kojima; Hisashi Ohno; Eita Sasaki; Toru Komatsu; Tasuku Ueno; Kazuya Maeda; Hiroyuki Kusuhara; Yasuteru Urano

  Science advances, 2024年02月16日

  
• Virological characteristics of the SARS-CoV-2 BA.2.86 variant.

  Tomokazu Tamura; Keita Mizuma; Hesham Nasser; Sayaka Deguchi; Miguel Padilla-Blanco; Yoshitaka Oda; Keiya Uriu; Jarel E M Tolentino; Shuhei Tsujino; Rigel Suzuki; Isshu Kojima; Naganori Nao; Ryo Shimizu; Lei Wang; Masumi Tsuda; Michael Jonathan; Yusuke Kosugi; Ziyi Guo; Alfredo A Hinay Jr; Olivia Putri; Yoonjin Kim; Yuri L Tanaka; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Akatsuki Saito; Jumpei Ito; Takashi Irie; Shinya Tanaka; Jiri Zahradnik; Terumasa Ikeda; Kazuo Takayama; Keita Matsuno; Takasuke Fukuhara; Kei Sato

  Cell host & microbe, 2024年02月14日

  この論文にアクセスする：

  
• Complement factor D targeting protects endotheliopathy in organoid and monkey models of COVID-19.

  Eri Kawakami; Norikazu Saiki; Yosuke Yoneyama; Chiharu Moriya; Mari Maezawa; Shuntaro Kawamura; Akiko Kinebuchi; Tamaki Kono; Masaaki Funata; Ayaka Sakoda; Shigeru Kondo; Takeshi Ebihara; Hisatake Matsumoto; Yuki Togami; Hiroshi Ogura; Fuminori Sugihara; Daisuke Okuzaki; Takashi Kojima; Sayaka Deguchi; Sebastien Vallee; Susan McQuade; Rizwana Islam; Madhusudan Natarajan; Hirohito Ishigaki; Misako Nakayama; Cong Thanh Nguyen; Yoshinori Kitagawa; Yunheng Wu; Kensaku Mori; Takayuki Hishiki; Tomohiko Takasaki; Yasushi Itoh; Kazuo Takayama; Yasunori Nio; Takanori Takebe

  Cell stem cell, 2023年10月05日

  
• SARS-CoV-2-induced disruption of a vascular bed in a microphysiological system caused by type-I interferon from bronchial organoids.

  Kazuya Fujimoto; Yoshikazu Kameda; Yuta Nagano; Sayaka Deguchi; Takuya Yamamoto; Rafal P Krol; Peter Gee; Yasufumi Matsumura; Toru Okamoto; Miki Nagao; Kazuo Takayama; Ryuji Yokokawa

  Lab on a chip, 2024年01月22日

  
• Virological characteristics of the SARS-CoV-2 Omicron XBB.1.5 variant.

  Tomokazu Tamura; Takashi Irie; Sayaka Deguchi; Hisano Yajima; Masumi Tsuda; Hesham Nasser; Keita Mizuma; Arnon Plianchaisuk; Saori Suzuki; Keiya Uriu; Mst Monira Begum; Ryo Shimizu; Michael Jonathan; Rigel Suzuki; Takashi Kondo; Hayato Ito; Akifumi Kamiyama; Kumiko Yoshimatsu; Maya Shofa; Rina Hashimoto; Yuki Anraku; Kanako Terakado Kimura; Shunsuke Kita; Jiei Sasaki; Kaori Sasaki-Tabata; Katsumi Maenaka; Naganori Nao; Lei Wang; Yoshitaka Oda; Terumasa Ikeda; Akatsuki Saito; Keita Matsuno; Jumpei Ito; Shinya Tanaka; Kei Sato; Takao Hashiguchi; Kazuo Takayama; Takasuke Fukuhara

  Nature communications, 2024年02月08日

  この論文にアクセスする：

  
• Generation of human bronchial organoids for SARS-CoV-2 research

  Tatsuya Suzuki; Yumi Itoh; Yusuke Sakai; Akatsuki Saito; Daisuke Okuzaki; Daisuke Motooka; Shohei Minami; Takeshi Kobayashi; Takuya Yamamoto; Toru Okamoto; Kazuo Takayama

  2020年05月26日, 査読有り

  
• Pluripotent stem cell-based therapies and their path to the clinic.

  Kazuo Takayama; Shinya Yamanaka

  Stem cell reports, 2023年08月08日

  この論文にアクセスする：

  
• Comparative pathogenicity of SARS-CoV-2 Omicron subvariants including BA.1, BA.2, and BA.5.

  Tomokazu Tamura; Daichi Yamasoba; Yoshitaka Oda; Jumpei Ito; Tomoko Kamasaki; Naganori Nao; Rina Hashimoto; Yoichiro Fujioka; Rigel Suzuki; Lei Wang; Hayato Ito; Yukie Kashima; Izumi Kimura; Mai Kishimoto; Masumi Tsuda; Hirofumi Sawa; Kumiko Yoshimatsu; Yuki Yamamoto; Tetsuharu Nagamoto; Jun Kanamune; Yutaka Suzuki; Yusuke Ohba; Isao Yokota; Keita Matsuno; Kazuo Takayama; Shinya Tanaka; Kei Sato; Takasuke Fukuhara

  Communications biology, 2023年07月24日

  この論文にアクセスする：

  
• SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response

  Shunya Tsuji; Shohei Minami; Rina Hashimoto; Yusuke Konishi; Tatsuya Suzuki; Tamae Kondo; Miwa Sasai; Shiho Torii; Chikako Ono; Shintaro Shichinohe; Shintaro Sato; Masahiro Wakita; Shintaro Okumura; Sosuke Nakano; Tatsuyuki Matsudaira; Tomonori Matsumoto; Shimpei Kawamoto; Masahiro Yamamoto; Tokiko Watanabe; Yoshiharu Matsuura; Kazuo Takayama; Takeshi Kobayashi; Toru Okamoto; Eiji Hara

  Nature Aging, 2022年02月

  
• Virological characterization of the 2022 outbreak-causing monkeypox virus using human keratinocytes and colon organoids.

  Yukio Watanabe; Izumi Kimura; Rina Hashimoto; Ayaka Sakamoto; Naoko Yasuhara; Takuya Yamamoto; Kei Sato; Kazuo Takayama

  Journal of medical virology, 2023年06月

  この論文にアクセスする：

  
• Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants.

  Tomokazu Tamura; Jumpei Ito; Keiya Uriu; Jiri Zahradnik; Izumi Kida; Yuki Anraku; Hesham Nasser; Maya Shofa; Yoshitaka Oda; Spyros Lytras; Naganori Nao; Yukari Itakura; Sayaka Deguchi; Rigel Suzuki; Lei Wang; Mst Monira Begum; Shunsuke Kita; Hisano Yajima; Jiei Sasaki; Kaori Sasaki-Tabata; Ryo Shimizu; Masumi Tsuda; Yusuke Kosugi; Shigeru Fujita; Lin Pan; Daniel Sauter; Kumiko Yoshimatsu; Saori Suzuki; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Yuki Yamamoto; Tetsuharu Nagamoto; Gideon Schreiber; Katsumi Maenaka; Takao Hashiguchi; Terumasa Ikeda; Takasuke Fukuhara; Akatsuki Saito; Shinya Tanaka; Keita Matsuno; Kazuo Takayama; Kei Sato

  Nature communications, 2023年05月16日

  この論文にアクセスする：

  
• Convergent evolution of SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant.

  Jumpei Ito; Rigel Suzuki; Keiya Uriu; Yukari Itakura; Jiri Zahradnik; Kanako Terakado Kimura; Sayaka Deguchi; Lei Wang; Spyros Lytras; Tomokazu Tamura; Izumi Kida; Hesham Nasser; Maya Shofa; Mst Monira Begum; Masumi Tsuda; Yoshitaka Oda; Tateki Suzuki; Jiei Sasaki; Kaori Sasaki-Tabata; Shigeru Fujita; Kumiko Yoshimatsu; Hayato Ito; Naganori Nao; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Yuki Yamamoto; Tetsuharu Nagamoto; Jin Kuramochi; Gideon Schreiber; Akatsuki Saito; Keita Matsuno; Kazuo Takayama; Takao Hashiguchi; Shinya Tanaka; Takasuke Fukuhara; Terumasa Ikeda; Kei Sato

  Nature communications, 2023年05月11日

  この論文にアクセスする：

  
• Organ-on-a-chip models for elucidating the cellular biology of infectious diseases.

  Fuki Yokoi; Sayaka Deguchi; Kazuo Takayama

  Biochimica et biophysica acta. Molecular cell research, 2023年05月26日

  
• Evaluation of Broad Anti-Coronavirus Activity of Autophagy-Related Compounds Using Human Airway Organoids.

  Rina Hashimoto; Tomokazu Tamura; Yukio Watanabe; Ayaka Sakamoto; Naoko Yasuhara; Hayato Ito; Masahiro Nakano; Hiromitsu Fuse; Akira Ohta; Takeshi Noda; Yasufumi Matsumura; Miki Nagao; Takuya Yamamoto; Takasuke Fukuhara; Kazuo Takayama

  Molecular pharmaceutics, 2023年04月03日

  
• Elucidation of the liver pathophysiology of COVID-19 patients using liver-on-a-chips.

  Sayaka Deguchi; Kaori Kosugi; Rina Hashimoto; Ayaka Sakamoto; Masaki Yamamoto; Rafal P Krol; Peter Gee; Ryosuke Negoro; Takeshi Noda; Takuya Yamamoto; Yu-Suke Torisawa; Miki Nagao; Kazuo Takayama

  PNAS nexus, 2023年03月

  この論文にアクセスする：

  
• [State-of-the-art in respiratory disease research using respiratory organoids].

  Sayaka Deguchi; Kazuo Takayama

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 2023年

  
• Design of a chimeric ACE-2/Fc-silent fusion protein with ultrahigh affinity and neutralizing capacity for SARS-CoV-2 variants.

  Neil M Bodie; Rina Hashimoto; David Connolly; Jennifer Chu; Kazuo Takayama; Bruce D Uhal

  Antibody therapeutics, 2023年01月

  この論文にアクセスする：

  
• Non-uniform aspects of the SARS-CoV-2 intraspecies evolution reopen question of its origin.

  Sk Sarif Hassan; Vaishnavi Kodakandla; Elrashdy M Redwan; Kenneth Lundstrom; Pabitra Pal Choudhury; Ángel Serrano-Aroca; Gajendra Kumar Azad; Alaa A A Aljabali; Giorgio Palu; Tarek Mohamed Abd El-Aziz; Debmalya Barh; Bruce D Uhal; Parise Adadi; Kazuo Takayama; Nicolas G Bazan; Murtaza Tambuwala; Samendra P Sherchan; Amos Lal; Gaurav Chauhan; Wagner Baetas-da-Cruz; Vladimir N Uversky

  International journal of biological macromolecules, 2022年12月01日

  
• Exocyst complex component 2 is a potential host factor for SARS-CoV-2 infection.

  Renxing Yi; Rina Hashimoto; Ayaka Sakamoto; Yasufumi Matsumura; Miki Nagao; Kazutoshi Takahashi; Kazuo Takayama

  iScience, 2022年11月18日

  この論文にアクセスする：

  
• Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant.

  Akatsuki Saito; Tomokazu Tamura; Jiri Zahradnik; Sayaka Deguchi; Koshiro Tabata; Yuki Anraku; Izumi Kimura; Jumpei Ito; Daichi Yamasoba; Hesham Nasser; Mako Toyoda; Kayoko Nagata; Keiya Uriu; Yusuke Kosugi; Shigeru Fujita; Maya Shofa; Mst Monira Begum; Ryo Shimizu; Yoshitaka Oda; Rigel Suzuki; Hayato Ito; Naganori Nao; Lei Wang; Masumi Tsuda; Kumiko Yoshimatsu; Jin Kuramochi; Shunsuke Kita; Kaori Sasaki-Tabata; Hideo Fukuhara; Katsumi Maenaka; Yuki Yamamoto; Tetsuharu Nagamoto; Hiroyuki Asakura; Mami Nagashima; Kenji Sadamasu; Kazuhisa Yoshimura; Takamasa Ueno; Gideon Schreiber; Akifumi Takaori-Kondo; Kotaro Shirakawa; Hirofumi Sawa; Takashi Irie; Takao Hashiguchi; Kazuo Takayama; Keita Matsuno; Shinya Tanaka; Terumasa Ikeda; Takasuke Fukuhara; Kei Sato

  Cell host & microbe, 2022年11月09日

  この論文にアクセスする：

  
• Therapeutic Potential of Cannabinoids on Tumor Microenvironment: A Molecular Switch in Neoplasia Transformation.

  Hamid A Bakshi; Hakkim L Faruck; Zeinab Ravesh; Prawej Ansari; J M A Hannan; Rina Hashimoto; Kazuo Takayama; Rabia Farzand; Mohamed M Nasef; Adelaide Mensah; Alaa A A Aljabali; Vijay Mishra; Nitin B Charbe; Rohit Goyal; Poonam Negi; Ángel Serrano-Aroca; Bojlul Bahar; Mohamed El-Tanani; Aaron J Courtenay; Paul McCarron; Iain G Jack; Murtaza M Tambuwala

  Integrative cancer therapies, 2022年

  
• Intestinal Permeability of Drugs in Caco-2 Cells Cultured in Microfluidic Devices.

  Yuko Sasaki; Hirotaka Tatsuoka; Masahiro Tsuda; Takumi Sumi; Yuka Eguchi; Kanako So; Yuriko Higuchi; Kazuo Takayama; Yusuke Torisawa; Fumiyoshi Yamashita

  Biological & pharmaceutical bulletin, 2022年, 査読有り

  
• Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models.

  Maaya Morita; Aki Yoneda; Nagisa Tokunoh; Tatsumi Masaki; Keisuke Shirakura; Mayumi Kinoshita; Rina Hashimoto; Naoya Shigesada; Junya Takahashi; Masashi Tachibana; Shota Tanaka; Masanori Obana; Nobumasa Hino; Masahito Ikawa; Kazutake Tsujikawa; Chikako Ono; Yoshiharu Matsuura; Hiroyasu Kidoya; Nobuyuki Takakura; Yoshiaki Kubota; Takefumi Doi; Kazuo Takayama; Yasuo Yoshioka; Yasushi Fujio; Yoshiaki Okada

  Proceedings of the National Academy of Sciences of the United States of America, 2023年01月17日

  
• State-of-the-art liver disease research using liver-on-a-chip.

  Sayaka Deguchi; Kazuo Takayama

  Inflammation and regeneration, 2022年12月09日

  この論文にアクセスする：

  
• Application of perfluoropolyether elastomers in microfluidic drug metabolism assays.

  Mengyang Wang; Masahiro Tsuda; Sayaka Deguchi; Yuriko Higuchi; Kanako So; Yu-Suke Torisawa; Kazuo Takayama; Fumiyoshi Yamashita

  International journal of pharmaceutics, 2022年11月05日

  
• SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression.

  Rina Hashimoto; Junya Takahashi; Keisuke Shirakura; Risa Funatsu; Kaori Kosugi; Sayaka Deguchi; Masaki Yamamoto; Yugo Tsunoda; Maaya Morita; Kosuke Muraoka; Masato Tanaka; Tomoaki Kanbara; Shota Tanaka; Shigeyuki Tamiya; Nagisa Tokunoh; Atsushi Kawai; Masahito Ikawa; Chikako Ono; Keisuke Tachibana; Masuo Kondoh; Masanori Obana; Yoshiharu Matsuura; Akihiro Ohsumi; Takeshi Noda; Takuya Yamamoto; Yasuo Yoshioka; Yu-Suke Torisawa; Hiroshi Date; Yasushi Fujio; Miki Nagao; Kazuo Takayama; Yoshiaki Okada

  Science advances, 2022年09月23日

  この論文にアクセスする：

  
• Generation of HepG2 Cells with High Expression of Multiple Drug-Metabolizing Enzymes for Drug Discovery Research Using a PITCh System.

  Ryosuke Negoro; Mitsuki Tasaka; Sayaka Deguchi; Kazuo Takayama; Takuya Fujita

  Cells, 2022年05月18日

  
• Decellularized Organ-Derived Scaffold Is a Promising Carrier for Human Induced Pluripotent Stem Cells-Derived Hepatocytes.

  Hideaki Kojima; Hiroshi Yagi; Hiroko Kushige; Yukiko Toda; Kazuo Takayama; Shinako Masuda; Toshinori Morisaku; Tomonori Tsuchida; Kohei Kuroda; Kazuya Hirukawa; Jumpei Inui; Kotaro Nishi; Yutaka Nakano; Masayuki Tanaka; Shutaro Hori; Yasushi Hasegawa; Yuta Abe; Minoru Kitago; Shungo Adachi; Masatoshi Tomi; Katsuhisa Matsuura; Hiroyuki Mizuguchi; Yuko Kitagawa

  Cells, 2022年04月07日

  
• Biocompatible Films of Calcium Alginate Inactivate Enveloped Viruses Such as SARS-CoV-2.

  Alba Cano-Vicent; Rina Hashimoto; Kazuo Takayama; Ángel Serrano-Aroca

  Polymers, 2022年04月06日

  
• An issue of concern: unique truncated ORF8 protein variants of SARS-CoV-2.

  Sk Sarif Hassan; Vaishnavi Kodakandla; Elrashdy M Redwan; Kenneth Lundstrom; Pabitra Pal Choudhury; Tarek Mohamed Abd El-Aziz; Kazuo Takayama; Ramesh Kandimalla; Amos Lal; Ángel Serrano-Aroca; Gajendra Kumar Azad; Alaa A A Aljabali; Giorgio Palù; Gaurav Chauhan; Parise Adadi; Murtaza Tambuwala; Adam M Brufsky; Wagner Baetas-da-Cruz; Debmalya Barh; Vasco Azevedo; Nikolas G Bazan; Bruno Silva Andrade; Raner José Santana Silva; Vladimir N Uversky

  PeerJ, 2022年

  
• Cell response analysis in SARS-CoV-2 infected bronchial organoids

  Emi Sano; Tatsuya Suzuki; Rina Hashimoto; Yumi Itoh; Ayaka Sakamoto; Yusuke Sakai; Akatsuki Saito; Daisuke Okuzaki; Daisuke Motooka; Yukiko Muramoto; Takeshi Noda; Tomohiko Takasaki; Jun-Ichi Sakuragi; Shohei Minami; Takeshi Kobayashi; Takuya Yamamoto; Yasufumi Matsumura; Miki Nagao; Toru Okamoto; Kazuo Takayama

  Communications Biology, 2022年12月, 査読有り

  この論文にアクセスする：

  
• Dual inhibition of TMPRSS2 and Cathepsin Bprevents SARS-CoV-2 infection in iPS cells.

  Rina Hashimoto; Ayaka Sakamoto; Sayaka Deguchi; Renxing Yi; Emi Sano; Akitsu Hotta; Kazutoshi Takahashi; Shinya Yamanaka; Kazuo Takayama

  Molecular therapy. Nucleic acids, 2021年12月03日

  この論文にアクセスする：

  
• Clinical utility of novel biosensing platform: Diagnosis of coronavirus SARS-CoV-2 at point of care.

  Alaa A A Aljabali; Kaushik Pal; Angel Serrano-Aroca; Kazuo Takayama; Kamal Dua; Murtaza M Tambuwala

  Materials letters, 2021年12月01日

  
• Protective Face Masks: Current Status and Future Trends.

  Alberto Tuñón-Molina; Kazuo Takayama; Elrashdy M Redwan; Vladimir N Uversky; Juan Andrés; Ángel Serrano-Aroca

  ACS applied materials & interfaces, 2021年11月19日

  
• Generation of Tetrafluoroethylene-Propylene Elastomer-Based Microfluidic Devices for Drug Toxicity and Metabolism Studies.

  Emi Sano; Sayaka Deguchi; Naoki Matsuoka; Masahiro Tsuda; Mengyang Wang; Kaori Kosugi; Chihiro Mori; Keisuke Yagi; Aya Wada; Shinsuke Yamasaki; Tsuyoshi Kawai; Masahide Yodogawa; Hiroyuki Mizuguchi; Norihito Nakazawa; Fumiyoshi Yamashita; Yu-Suke Torisawa; Kazuo Takayama

  ACS omega, 2021年09月28日

  この論文にアクセスする：

  
• Potential Molecular Mechanisms of Rare Anti-Tumor Immune Response by SARS-CoV-2 in Isolated Cases of Lymphomas.

  Debmalya Barh; Sandeep Tiwari; Lucas Gabriel Rodrigues Gomes; Marianna E Weener; Khalid J Alzahrani; Khalaf F Alsharif; Alaa A A Aljabali; Murtaza M Tambuwala; Kenneth Lundstrom; Sk Sarif Hassan; Ángel Serrano-Aroca; Kazuo Takayama; Preetam Ghosh; Elrashdy M Redwan; Bruno Silva Andrade; Siomar de Castro Soares; Vasco Azevedo; Vladimir N Uversky

  Viruses, 2021年09月25日

  
• Implications derived from S-protein variants of SARS-CoV-2 from six continents.

  Sk Sarif Hassan; Kenneth Lundstrom; Debmalya Barh; Raner Jośe Santana Silva; Bruno Silva Andrade; Vasco Azevedo; Pabitra Pal Choudhury; Giorgio Palu; Bruce D Uhal; Ramesh Kandimalla; Murat Seyran; Amos Lal; Samendra P Sherchan; Gajendra Kumar Azad; Alaa A A Aljabali; Adam M Brufsky; Ángel Serrano-Aroca; Parise Adadi; Tarek Mohamed Abd El-Aziz; Elrashdy M Redwan; Kazuo Takayama; Nima Rezaei; Murtaza Tambuwala; Vladimir N Uversky

  International journal of biological macromolecules, 2021年09月24日

  
• Periodically aperiodic pattern of SARS-CoV-2 mutations underpins the uncertainty of its origin and evolution.

  Sk Sarif Hassan; Pallab Basu; Elrashdy M Redwan; Kenneth Lundstrom; Pabitra Pal Choudhury; Angel Serrano-Aroca; Gajendra Kumar Azad; Alaa A A Aljabali; Giorgio Palu; Tarek Mohamed Abd El-Aziz; Debmalya Barh; Bruce D Uhal; Parise Adadi; Kazuo Takayama; Nicolas G Bazan; Murtaza Tambuwala; Amos Lal; Gaurav Chauhan; Wagner Baetas-da-Cruz; Samendra P Sherchan; Vladimir N Uversky

  Environmental research, 2021年09月22日

  
• Antiviral Face Mask Functionalized with Solidified Hand Soap: Low-Cost Infection Prevention Clothing against Enveloped Viruses Such as SARS-CoV-2.

  Alba Cano-Vicent; Alberto Tuñón-Molina; Miguel Martí; Yukiko Muramoto; Takeshi Noda; Kazuo Takayama; Ángel Serrano-Aroca

  ACS omega, 2021年09月14日

  この論文にアクセスする：

  
• Autoimmunity roots of the thrombotic events after COVID-19 vaccination.

  Fatma Elrashdy; Murtaza M Tambuwala; Sk Sarif Hassan; Parise Adadi; Murat Seyran; Tarek Mohamed Abd El-Aziz; Nima Rezaei; Amos Lal; Alaa A A Aljabali; Ramesh Kandimalla; Nicolas G Bazan; Gajendra Kumar Azad; Samendra P Sherchan; Pabitra Pal Choudhury; Ángel Serrano-Aroca; Kazuo Takayama; Gaurav Chauhan; Damiano Pizzol; Debmalya Barh; Pritam Kumar Panda; Yogendra K Mishra; Giorgio Palù; Kenneth Lundstrom; Elrashdy M Redwan; Vladimir N Uversky

  Autoimmunity reviews, 2021年09月09日

  
• Antimicrobial Face Shield: Next Generation of Facial Protective Equipment against SARS-CoV-2 and Multidrug-Resistant Bacteria.

  Alberto Tuñón-Molina; Miguel Martí; Yukiko Muramoto; Takeshi Noda; Kazuo Takayama; Ángel Serrano-Aroca

  International journal of molecular sciences, 2021年09月01日

  
• Usability of Polydimethylsiloxane-Based Microfluidic Devices in Pharmaceutical Research Using Human Hepatocytes.

  Sayaka Deguchi; Masahiro Tsuda; Kaori Kosugi; Ayaka Sakamoto; Natsumi Mimura; Ryosuke Negoro; Emi Sano; Takuro Nobe; Kazuya Maeda; Hiroyuki Kusuhara; Hiroyuki Mizuguchi; Fumiyoshi Yamashita; Yu-Suke Torisawa; Kazuo Takayama

  ACS biomaterials science & engineering, 2021年08月09日

  
• In Vitro Model for a Drug Assessment of Cytochrome P450 Family 3 Subfamily A Member 4 Substrates Using Human Induced Pluripotent Stem Cells and Genome Editing Technology.

  Sayaka Deguchi; Tomohiro Shintani; Kazuo Harada; Toru Okamoto; Akinori Takemura; Kazumasa Hirata; Kousei Ito; Kazuo Takayama; Hiroyuki Mizuguchi

  Hepatology communications, 2021年08月

  
• SARS-CoV-2 research using human pluripotent stem cells and organoids.

  Sayaka Deguchi; Ángel Serrano-Aroca; Murtaza M Tambuwala; Bruce D Uhal; Adam M Brufsky; Kazuo Takayama

  Stem cells translational medicine, 2021年07月24日

  この論文にアクセスする：

  
• The mechanism behind flaring/triggering of autoimmunity disorders associated with COVID-19.

  Elrashdy M Redwan; Mohammed F Alghamdi; Tarek Mohamed Abd El-Aziz; Parise Adadi; Alaa A A Aljabali; Diksha Attrish; Gajendra Kumar Azad; Wagner Baetas-da-Cruz; Debmalya Barh; Nicolas G Bazan; Adam M Brufsky; Gaurav Chauhan; S K Sarif Hassan; Ramesh Kandimalla; Amos Lal; Kenneth Lundstrom; Yogendra Kumar Mishra; Pabitra Pal Choudhury; Giorgio Palù; Pritam K Panda; Damiano Pizzol; Nima Rezaei; Ángel Serrano-Aroca; Samendra P Sherchan; Murat Seyran; Kazuo Takayama; Murtaza M Tambuwala; Bruce D Uhal; Vladimir N Uversky

  Autoimmunity reviews, 2021年07月16日

  
• Targeting LIN28: a new hope in prostate cancer theranostics.

  Garima Shrivastava; Alaa Aa Aljabali; Seyed Hossein Shahcheraghi; Marzieh Lotfi; Madhur D Shastri; Shakti D Shukla; Dinesh K Chellappan; Niraj Kumar Jha; Krishnan Anand; Harish Dureja; Ritesh M Pabari; Vijay Mishra; Abdulmajeed G Almutary; Abdullah M Alnuqaydan; Nitin Charbe; Parteek Prasher; Poonam Negi; Rohit Goyal; Kamal Dua; Gaurav Gupta; Ángel Serrano-Aroca; Bojlul Bahar; Debmalya Barh; Pritam Kumar Panda; Kazuo Takayama; Kenneth Lundstrom; Paul McCarron; Hamid Bakshi; Murtaza M Tambuwala

  Future oncology (London, England), 2021年07月15日

  
• COVID-19 Vaccines and Thrombosis-Roadblock or Dead-End Street?

  Kenneth Lundstrom; Debmalya Barh; Bruce D Uhal; Kazuo Takayama; Alaa A A Aljabali; Tarek Mohamed Abd El-Aziz; Amos Lal; Elrashdy M Redwan; Parise Adadi; Gaurav Chauhan; Samendra P Sherchan; Gajendra Kumar Azad; Nima Rezaei; Ángel Serrano-Aroca; Nicolas G Bazan; Sk Sarif Hassan; Pritam Kumar Panda; Pabitra Pal Choudhury; Damiano Pizzol; Ramesh Kandimalla; Wagner Baetas-da-Cruz; Yogendra Kumar Mishra; Giorgio Palu; Adam M Brufsky; Murtaza M Tambuwala; Vladimir N Uversky

  Biomolecules, 2021年07月13日

  
• Generation of tetracycline-controllable CYP3A4-expressing Caco-2 cells by the piggyBac transposon system.

  Moe Ichikawa; Hiroki Akamine; Michika Murata; Sumito Ito; Kazuo Takayama; Hiroyuki Mizuguchi

  Scientific reports, 2021年06月03日

  
• A unique view of SARS-CoV-2 through the lens of ORF8 protein.

  Sk Sarif Hassan; Alaa A A Aljabali; Pritam Kumar Panda; Shinjini Ghosh; Diksha Attrish; Pabitra Pal Choudhury; Murat Seyran; Damiano Pizzol; Parise Adadi; Tarek Mohamed Abd El-Aziz; Antonio Soares; Ramesh Kandimalla; Kenneth Lundstrom; Amos Lal; Gajendra Kumar Azad; Vladimir N Uversky; Samendra P Sherchan; Wagner Baetas-da-Cruz; Bruce D Uhal; Nima Rezaei; Gaurav Chauhan; Debmalya Barh; Elrashdy M Redwan; Guy W Dayhoff 2nd; Nicolas G Bazan; Ángel Serrano-Aroca; Amr El-Demerdash; Yogendra K Mishra; Giorgio Palu; Kazuo Takayama; Adam M Brufsky; Murtaza M Tambuwala

  Computers in biology and medicine, 2021年06月

  
• Carbon-Based Nanomaterials: Promising Antiviral Agents to Combat COVID-19 in the Microbial-Resistant Era.

  Ángel Serrano-Aroca; Kazuo Takayama; Alberto Tuñón-Molina; Murat Seyran; Sk Sarif Hassan; Pabitra Pal Choudhury; Vladimir N Uversky; Kenneth Lundstrom; Parise Adadi; Giorgio Palù; Alaa A A Aljabali; Gaurav Chauhan; Ramesh Kandimalla; Murtaza M Tambuwala; Amos Lal; Tarek Mohamed Abd El-Aziz; Samendra Sherchan; Debmalya Barh; Elrashdy M Redwan; Nicolas G Bazan; Yogendra Kumar Mishra; Bruce D Uhal; Adam Brufsky

  ACS nano, 2021年05月25日

  
• Modeling SARS-CoV-2 infection and its individual differences with ACE2-expressing human iPS cells.

  Emi Sano; Sayaka Deguchi; Ayaka Sakamoto; Natsumi Mimura; Ai Hirabayashi; Yukiko Muramoto; Takeshi Noda; Takuya Yamamoto; Kazuo Takayama

  iScience, 2021年05月21日

  この論文にアクセスする：

  
• Overview of key molecular and pharmacological targets for diabetes and associated diseases.

  Seyed Hossein Shahcheraghi; Alaa A A Aljabali; Mazhar S Al Zoubi; Vijay Mishra; Nitin B Charbe; Yusuf A Haggag; Garima Shrivastava; Abdulmajeed G Almutary; Abdullah M Alnuqaydan; Debmalya Barh; Kamal Dua; Dinesh K Chellappan; Gaurav Gupta; Marzieh Lotfi; Ángel Serrano-Aroca; Bojlul Bahar; Yogendra Kumar Mishra; Kazuo Takayama; Pritam Kumar Panda; Hamid A Bakshi; Murtaza M Tambuwala

  Life sciences, 2021年05月18日

  
• Notable sequence homology of the ORF10 protein introspects the architecture of SARS-CoV-2.

  Sk Sarif Hassan; Diksha Attrish; Shinjini Ghosh; Pabitra Pal Choudhury; Vladimir N Uversky; Alaa A A Aljabali; Kenneth Lundstrom; Bruce D Uhal; Nima Rezaei; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza M Tambuwala; Gajendra Kumar Azad; Samendra P Sherchan; Wagner Baetas-da-Cruz; Amos Lal; Giorgio Palù; Kazuo Takayama; Ángel Serrano-Aroca; Debmalya Barh; Adam M Brufsky

  International journal of biological macromolecules, 2021年04月16日

  
• Asymmetric profiles of infection and innate immunological responses in human iPS cell-derived small intestinal epithelial-like cell monolayers following infection with mammalian reovirus.

  Chieko Inoue; Ryosuke Negoro; Kazuo Takayama; Hiroyuki Mizuguchi; Fuminori Sakurai

  Virus research, 2021年04月15日

  
• Vinblastine treatment decreases the undifferentiated cell contamination of human iPSC-derived intestinal epithelial-like cells.

  Moe Ichikawa; Ryosuke Negoro; Kanae Kawai; Tomoki Yamashita; Kazuo Takayama; Hiroyuki Mizuguchi

  Molecular therapy. Methods & clinical development, 2021年03月12日

  
• In Vivo Gene Expression Profile of Human Intestinal Epithelial Cells: From the Viewpoint of Drug Metabolism and Pharmacokinetics.

  Kazuo Takayama; Kohei Ito; Akiko Matsui; Tomoki Yamashita; Kentaro Kawakami; Daisuke Hirayama; Wataru Kishimoto; Hiroshi Nakase; Hiroyuki Mizuguchi

  Drug metabolism and disposition: the biological fate of chemicals, 2021年03月

  
• Protective Face Mask Filter Capable of Inactivating SARS-CoV-2, and Methicillin-Resistant Staphylococcus aureus and Staphylococcus epidermidis.

  Miguel Martí; Alberto Tuñón-Molina; Finn Lillelund Aachmann; Yukiko Muramoto; Takeshi Noda; Kazuo Takayama; Ángel Serrano-Aroca

  Polymers, 2021年01月08日

  
• Generation of Hepatocytes from Human ES/iPS Cells for Regenerative Medicine

  Tomoki Yamashita; Kazuo Takayama; Hiroyuki Mizuguchi

  Cell-Inspired Materials and Engineering, 2021年

  
• Possible Transmission Flow of SARS-CoV-2 Based on ACE2 Features.

  Sk Sarif Hassan; Shinjini Ghosh; Diksha Attrish; Pabitra Pal Choudhury; Alaa A A Aljabali; Bruce D Uhal; Kenneth Lundstrom; Nima Rezaei; Vladimir N Uversky; Murat Seyran; Damiano Pizzol; Parise Adadi; Antonio Soares; Tarek Mohamed Abd El-Aziz; Ramesh Kandimalla; Murtaza M Tambuwala; Gajendra Kumar Azad; Samendra P Sherchan; Wagner Baetas-da-Cruz; Kazuo Takayama; Ángel Serrano-Aroca; Gaurav Chauhan; Giorgio Palu; Adam M Brufsky

  Molecules (Basel, Switzerland), 2020年12月13日

  
• Introductions to the Community: Early-Career Researchers in the Time of COVID-19.

  Kazuo Takayama; Lesley N Weaver; Edroaldo Lummertz da Rocha; Valentina Lo Sardo; Helmuth Gehart; Ly P Vu

  Cell stem cell, 2020年12月03日

  
• The structural basis of accelerated host cell entry by SARS-CoV-2†.

  Murat Seyran; Kazuo Takayama; Vladimir N Uversky; Kenneth Lundstrom; Giorgio Palù; Samendra P Sherchan; Diksha Attrish; Nima Rezaei; Alaa A A Aljabali; Shinjini Ghosh; Damiano Pizzol; Gaurav Chauhan; Parise Adadi; Tarek Mohamed Abd El-Aziz; Antonio G Soares; Ramesh Kandimalla; Murtaza Tambuwala; Sk Sarif Hassan; Gajendra Kumar Azad; Pabitra Pal Choudhury; Wagner Baetas-da-Cruz; Ángel Serrano-Aroca; Adam M Brufsky; Bruce D Uhal

  The FEBS journal, 2020年12月02日

  
• Photoactivatable oncolytic adenovirus for optogenetic cancer therapy.

  Yasuko Hagihara; Ayaka Sakamoto; Takashi Tokuda; Tomoki Yamashita; Sena Ikemoto; Ayaka Kimura; Makito Haruta; Kiyotaka Sasagawa; Jun Ohta; Kazuo Takayama; Hiroyuki Mizuguchi

  Cell death & disease, 2020年07月23日

  
• Establishment of SLC15A1/PEPT1-Knockout Human-Induced Pluripotent Stem Cell Line for Intestinal Drug Absorption Studies.

  Kanae Kawai; Ryosuke Negoro; Moe Ichikawa; Tomoki Yamashita; Sayaka Deguchi; Kazuo Harada; Kazumasa Hirata; Kazuo Takayama; Hiroyuki Mizuguchi

  Molecular therapy. Methods & clinical development, 2020年06月12日, 査読有り

  
• In Vitro and Animal Models for SARS-CoV-2 research.

  Kazuo Takayama

  Trends in pharmacological sciences, 2020年05月30日, 査読有り

  この論文にアクセスする：

  
• Tolloid-Like 1 Negatively Regulates Hepatic Differentiation of Human Induced Pluripotent Stem Cells Through Transforming Growth Factor Beta Signaling.

  Ayumi Kiso; Yukiko Toba; Susumu Tsutsumi; Sayaka Deguchi; Keisuke Igai; Saki Koshino; Yasuhito Tanaka; Kazuo Takayama; Hiroyuki Mizuguchi

  Hepatology communications, 2020年02月, 査読有り

  
• Comparison of commercially available media for hepatic differentiation and hepatocyte maintenance.

  Yukiko Toba; Sayaka Deguchi; Natsumi Mimura; Ayaka Sakamoto; Kazuo Harada; Kazumasa Hirata; Kazuo Takayama; Hiroyuki Mizuguchi

  PloS one, 2020年, 査読有り

  
• Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells.

  Sayaka Deguchi; Tomoki Yamashita; Keisuke Igai; Kazuo Harada; Yukiko Toba; Kazumasa Hirata; Kazuo Takayama; Hiroyuki Mizuguchi

  Drug metabolism and disposition: the biological fate of chemicals, 2019年06月, 査読有り

  
• FGF signal is not required for hepatoblast differentiation of human iPS cells.

  Yukiko Toba; Ayumi Kiso; Souichiro Nakamae; Fuminori Sakurai; Kazuo Takayama; Hiroyuki Mizuguchi

  Scientific reports, 2019年03月06日, 査読有り

  
• Pharmaceutical Research for Inherited Metabolic Disorders of the Liver Using Human Induced Pluripotent Stem Cell and Genome Editing Technologies.

  Tomoki Yamashita; Kazuo Takayama; Mika Hori; Mariko Harada-Shiba; Hiroyuki Mizuguchi

  Biological & pharmaceutical bulletin, 2019年, 査読有り

  
• Generation of Human iPSC-Derived Intestinal Epithelial Cell Monolayers by CDX2 Transduction.

  Takayama K; Negoro R; Yamashita T; Kawai K; Ichikawa M; Mori T; Nakatsu N; Harada K; Ito S; Yamada H; Yamaura Y; Hirata K; Ishida S; Mizuguchi H

  Cellular and molecular gastroenterology and hepatology, 2019年, 査読有り

  
• [Pharmaceutical Research on Liver Diseases Using iPS Cell and Genome Editing Technologies].

  Takayama K

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2019年, 査読有り

  
• Efficient Generation of Small Intestinal Epithelial-like Cells from Human iPSCs for Drug Absorption and Metabolism Studies.

  Ryosuke Negoro; Kazuo Takayama; Kanae Kawai; Kazuo Harada; Fuminori Sakurai; Kazumasa Hirata; Hiroyuki Mizuguchi

  Stem cell reports, 2018年12月11日, 査読有り

  
• Optimal human iPS cell culture method for efficient hepatic differentiation.

  Matoba N; Yamashita T; Takayama K; Sakurai F; Mizuguchi H

  Differentiation; research in biological diversity, 2018年09月, 査読有り

  
• Enrichment of high-functioning human iPS cell-derived hepatocyte-like cells for pharmaceutical research.

  Kazuo Takayama; Yasuko Hagihara; Yukiko Toba; Kiyotoshi Sekiguchi; Fuminori Sakurai; Hiroyuki Mizuguchi

  Biomaterials, 2018年04月, 査読有り

  
• Nanaomycin A Treatment Promotes Hepatoblast Differentiation from Human iPS Cells.

  Souichiro Nakamae; Yukiko Toba; Kazuo Takayama; Fuminori Sakurai; Hiroyuki Mizuguchi

  Stem cells and development, 2018年03月15日, 査読有り

  
• Billion-scale production of hepatocyte-like cells from human induced pluripotent stem cells.

  Tomoki Yamashita; Kazuo Takayama; Fuminori Sakurai; Hiroyuki Mizuguchi

  Biochemical and biophysical research communications, 2018年02月19日, 査読有り

  
• Generation of Optogenetically Modified Adenovirus Vector for Spatiotemporally Controllable Gene Therapy.

  Kazuo Takayama; Hiroyuki Mizuguchi

  ACS chemical biology, 2018年02月16日, 査読有り

  
• Human iPS Cell-based Liver-like Tissue Engineering at Extrahepatic Sites in Mice as a New Cell Therapy for Hemophilia B.

  Ryota Okamoto; Kazuo Takayama; Naoki Akita; Yasuhito Nagamoto; Daiki Hosokawa; Shunsuke Iizuka; Fuminori Sakurai; Hiroshi Suemizu; Kazuo Ohashi; Hiroyuki Mizuguchi

  Cell transplantation, 2018年02月, 査読有り

  
• Generation of safe and therapeutically effective human induced pluripotent stem cell-derived hepatocyte-like cells for regenerative medicine.

  Kazuo Takayama; Naoki Akita; Natsumi Mimura; Rina Akahira; Yukimasa Taniguchi; Makoto Ikeda; Fuminori Sakurai; Osamu Ohara; Tomohiro Morio; Kiyotoshi Sekiguchi; Hiroyuki Mizuguchi

  Hepatology communications, 2017年12月, 査読有り

  
• y Direct conversion of human fibroblasts into hepatocyte-like cells by ATF5, PROX1, FOXA2, FOXA3, and HNF4A transduction

  Daiki Nakamori; Hiroki Akamine; Kazuo Takayama; Fuminori Sakurai; Hiroyuki Mizuguchi

  SCIENTIFIC REPORTS, 2017年11月, 査読有り

  
• Hepatitis C virus-induced innate immune responses in human iPS cell-derived hepatocyte-like cells

  Fuminori Sakurai; Takemaru Kunito; Kazuo Takayama; Rina Hashimoto; Masashi Tachibana; Naoya Sakamoto; Takaji Wakita; Hiroyuki Mizuguchi

  VIRUS RESEARCH, 2017年10月, 査読有り

  
• Hepatocyte Nuclear Factor 4 Alpha Promotes Definitive Endoderm Differentiation from Human Induced Pluripotent Stem Cells

  Morifumi Hanawa; Kazuo Takayama; Fuminori Sakurai; Masashi Tachibana; Hiroyuki Mizuguchi

  STEM CELL REVIEWS AND REPORTS, 2017年08月, 査読有り

  
• Human ESC/iPSC-Derived Hepatocyte-like Cells Achieve Zone-Specific Hepatic Properties by Modulation of WNT Signaling

  Seiji Mitani; Kazuo Takayama; Yasuhito Nagamoto; Kazuo Imagawa; Fuminori Sakurai; Masashi Tachibana; Ryo Sumazaki; Hiroyuki Mizuguchi

  MOLECULAR THERAPY, 2017年06月, 査読有り

  
• Highly efficient biallelic genome editing of human ES/iPS cells using a CRISPR/Cas9 or TALEN system

  Kazuo Takayama; Keisuke Igai; Yasuko Hagihara; Rina Hashimoto; Morifumi Hanawa; Tetsushi Sakuma; Masashi Tachibana; Fuminori Sakurai; Takashi Yamamoto; Hiroyuki Mizuguchi

  NUCLEIC ACIDS RESEARCH, 2017年05月, 査読有り

  
• Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection

  Fuminori Sakurai; Seiji Mitani; Tatsuro Yamamoto; Kazuo Takayama; Masashi Tachibana; Koichi Watashi; Takaji Wakita; Sayuki Iijima; Yasuhito Tanaka; Hiroyuki Mizuguchi

  SCIENTIFIC REPORTS, 2017年04月, 査読有り

  
• Isolation and expansion of human pluripotent stem cell-derived hepatic progenitor cells by growth factor defined serum-free culture conditions

  Takayuki Fukuda; Kazuo Takayama; Mitsuhi Hirata; Yu-Jung Liu; Kana Yanagihara; Mika Suga; Hiroyuki Mizuguchi; Miho K. Furue

  EXPERIMENTAL CELL RESEARCH, 2017年03月, 査読有り

  
• Inhibition of CRISPR/Cas9-Mediated Genome Engineering by a Type I Interferon-Induced Reduction in Guide RNA Expression

  Mitsuhiro Machitani; Fuminori Sakurai; Keisaku Wakabayashi; Kosuke Nakatani; Kazuo Takayama; Masashi Tachibana; Hiroyuki Mizuguhi

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2017年03月, 査読有り

  
• Generation of a bile salt export pump deficiency model using patient-specific induced pluripotent stem cell-derived hepatocyte-like cells

  Kazuo Imagawa; Kazuo Takayama; Shigemi Isoyama; Ken Tanikawa; Masato Shinkai; Kazuo Harada; Masashi Tachibana; Fuminori Sakurai; Emiko Noguchi; Kazumasa Hirata; Masayoshi Kage; Kenji Kawabata; Ryo Sumazaki; Hiroyuki Mizuguchi

  Scientific Reports, 2017年02月, 査読有り

  
• Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening

  Kazuo Takayama; Hiroyuki Mizuguchi

  DRUG METABOLISM AND PHARMACOKINETICS, 2017年02月, 査読有り

  
• Prediction of Differentiation Tendency Toward Hepatocytes from Gene Expression in Undifferentiated Human Pluripotent Stem Cells

  Kana Yanagihara; Yujung Liu; Kei Kanie; Kazuo Takayama; Minako Kokunugi; Mitsuhi Hirata; Takayuki Fukuda; Mika Suga; Hiroki Nikawa; Hiroyuki Mizuguchi; Ryuji Kato; Miho K. Furue

  STEM CELLS AND DEVELOPMENT, 2016年12月, 査読有り

  
• Transplantation of a human iPSC-derived hepatocyte sheet increases survival in mice with acute liver failure

  Yasuhito Nagamoto; Kazuo Takayama; Kazuo Ohashi; Ryota Okamoto; Fuminori Sakurai; Masashi Tachibana; Kenji Kawabata; Hiroyuki Mizuguchi

  JOURNAL OF HEPATOLOGY, 2016年05月, 査読有り

  
• Laminin 411 and 511 promote the cholangiocyte differentiation of human induced pluripotent stem cells

  Kazuo Takayama; Seiji Mitani; Yasuhito Nagamoto; Fuminori Sakurai; Masashi Tachibana; Yukimasa Taniguchi; Kiyotoshi Sekiguchi; Hiroyuki Mizuguchi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016年05月, 査読有り

  
• Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cellst

  Ryosuke Negoro; Kazuo Takayama; Yasuhito Nagamoto; Fuminori Sakurai; Masashi Tachibana; Hiroyuki Mizuguchi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2016年04月, 査読有り

  
• Hepatic Maturation of Human iPS Cell-Derived Hepatocyte-Like Cells by ATF5, c/EBPα, and PROX1 Transduction

  Nakamori D; Takayama K; co-first author; Nagamoto Y; Mitani S; Sakurai F; Tachibana M; Mizuguchi H

  Biochem Biophys Res Commun., 2016年01月, 査読有り

  
• Generation of enterocyte-like cells from human induced pluripotent stem cells for drug absorption and metabolism studies in human small intestine

  Tatsuya Ozawa; Kazuo Takayama; Ryota Okamoto; Ryosuke Negoro; Fuminori Sakurai; Masashi Tachibana; Kenji Kawabata; Hiroyuki Mizuguchi

  SCIENTIFIC REPORTS, 2015年11月, 査読有り

  
• Establishment of a Method of Hepatocyte Differentiation from Human Pluripotent Stem Cells for Innovative Drug Development

  Kazuo Takayama

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 2015年10月, 査読有り

  
• Generation of Brain Microvascular Endothelial-Like Cells from Human Induced Pluripotent Stem Cells by Co-Culture with C6 Glioma Cells

  Haruka Minami; Katsuhisa Tashiro; Atsumasa Okada; Nobue Hirata; Tomoko Yamaguchi; Kazuo Takayama; Hiroyuki Mizuguchi; Kenji Kawabata

  PLOS ONE, 2015年06月, 査読有り

  
• Expression of Coxsackievirus and Adenovirus Receptor Separates Hematopoietic and Cardiac Progenitor Cells in Fetal Liver Kinase 1-Expressing Mesoderm

  Katsuhisa Tashiro; Nobue Hirata; Atsumasa Okada; Tomoko Yamaguchi; Kazuo Takayama; Hiroyuki Mizuguchi; Kenji Kawabata

  STEM CELLS TRANSLATIONAL MEDICINE, 2015年05月, 査読有り

  
• Expression of Coxsackievirus and Adenovirus Receptor Separates Hematopoietic and Cardiac Progenitor Cells in Fetal Liver Kinase 1-Expressing Mesoderm

  Katsuhisa Tashiro; Nobue Hirata; Atsumasa Okada; Tomoko Yamaguchi; Kazuo Takayama; Hiroyuki Mizuguchi; Kenji Kawabata

  STEM CELLS TRANSLATIONAL MEDICINE, 2015年05月, 査読有り

  
• Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene

  Yasuhito Nagamoto; Kazuo Takayama; Katsuhisa Tashiro; Chise Tateno; Fuminori Sakurai; Masashi Tachibana; Kenji Kawabata; Kazuo Ikeda; Yasuhito Tanaka; Hiroyuki Mizuguchi

  CELL TRANSPLANTATION, 2015年, 査読有り

  
• Efficient Engraftment of Human Induced Pluripotent Stem Cell-Derived Hepatocyte-Like Cells in uPA/SCID Mice by Overexpression of FNK, a Bcl-xL Mutant Gene

  Yasuhito Nagamoto; Kazuo Takayama; Katsuhisa Tashiro; Chise Tateno; Fuminori Sakurai; Masashi Tachibana; Kenji Kawabata; Kazuo Ikeda; Yasuhito Tanaka; Hiroyuki Mizuguchi

  CELL TRANSPLANTATION, 2015年, 査読有り

  
• Prediction of interindividual differences in hepatic functions and drug sensitivity by using human iPS-derived hepatocytes

  Kazuo Takayama; Yuta Morisaki; Shuichi Kuno; Yasuhito Nagamoto; Kazuo Harada; Norihisa Furukawa; Manami Ohtaka; Ken Nishimura; Kazuo Imagawa; Fuminori Sakurai; Masashi Tachibana; Ryo Sumazaki; Emiko Noguchi; Mahito Nakanishi; Kazumasa Hirata; Kenji Kawabata; Hiroyuki Mizuguchi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014年11月, 査読有り

  
• HHEX Promotes Hepatic-Lineage Specification through the Negative Regulation of Eomesodermin

  Hitoshi Watanabe; Kazuo Takayama; Mitsuru Inamura; Masashi Tachibana; Natsumi Mimura; Kazufumi Katayama; Katsuhisa Tashiro; Yasuhito Nagamoto; Fuminori Sakurai; Kenji Kawabata; Miho Kusuda Furue; Hiroyuki Mizuguchi

  PLOS ONE, 2014年03月, 査読有り

  
• CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determines the hepatoblast fate decision.

  Takayama K; Kawabata K; Nagamoto Y; Inamura M; Ohashi K; Okuno H; Yamaguchi T; Tashiro K; Sakurai F; Hayakawa T; Okano T; Furue MK; Mizuguchi H

  Development (Cambridge, England), 2014年01月, 査読有り

  
• CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determine the hepatoblast fate decision

  Takayama K; Kawabata K; Nagamoto Y; Inamura M; Ohashi K; Okuno H; Yamaguchi T; Tashiro K; Sakurai F; Hayakawa T; Okano T; Furue MK; Mizuguchi H

  Development, 2014年01月, 査読有り

  
• Long-Term Self-Renewal of Human ES/iPS-Derived Hepatoblast-like Cells on Human Laminin 111-Coated Dishes

  Kazuo Takayama; Yasuhito Nagamoto; Natsumi Mimura; Katsuhisa Tashiro; Fuminori Sakurai; Masashi Tachibana; Takao Hayakawa; Kenji Kawabata; Hiroyuki Mizuguchi

  STEM CELL REPORTS, 2013年10月, 査読有り

  
• 3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing.

  Kazuo Takayama; Kenji Kawabata; Yasuhito Nagamoto; Keisuke Kishimoto; Katsuhisa Tashiro; Fuminori Sakurai; Masashi Tachibana; Katsuhiro Kanda; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi

  Biomaterials, 2013年02月, 査読有り

  
• Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction.

  Takayama K; Inamura M; Kawabata K; Sugawara M; Kikuchi K; Higuchi M; Nagamoto Y; Watanabe H; Tashiro K; Sakurai F; Hayakawa T; Furue MK; Mizuguchi H

  Journal of Hepatology, 2012年09月, 査読有り

  
• The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets

  Yasuhito Nagamoto; Katsuhisa Tashiro; Kazuo Takayama; Kazuo Ohashi; Kenji Kawabata; Fuminori Sakurai; Masashi Tachibana; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi

  BIOMATERIALS, 2012年06月, 査読有り

  
• Efficient generation of functional hepatocytes from human embryonic stem cells and induced pluripotent stem cells by HNF4α transduction.

  Takayama K; Inamura M; Kawabata K; Katayama K; Higuchi M; Tashiro K; Nonaka A; Sakurai F; Hayakawa T; Furue MK; Mizuguchi H

  Molecular therapy : the journal of the American Society of Gene Therapy, 2012年01月, 査読有り

  
• Efficient generation of functional hepatocytes from human embryonic stem cells and induced cells by HNF4α transduction

  Takayama K; Inamura M; Kawabata K; Katayama K; Higuchi M; Tashiro K; Nonaka A; Sakurai F; Hayakawa T; Furue MK; Mizuguchi H

  Mol Ther., 2012年01月, 査読有り

  
• Endodermal and Hepatic Differentiation from Human Embryonic Stem Cells and Human Induced Pluripotent Stem Cells.

  Kawabata K; Takayama K; Nagamoto Y; Saldon M.S; Higuchi M; Mizuguchi H

  J Stem Cell Res Ther., 2012年, 査読有り

  
• Use of human hepatocyte-like cells derived from induced pluripotent stem cells as a model for hepatocytes in hepatitis C virus infection

  Takeshi Yoshida; Kazuo Takayama; Masuo Kondoh; Fuminori Sakurai; Hideki Tani; Naoya Sakamoto; Yoshiharu Matsuura; Hiroyuki Mizuguchi; Kiyohito Yagi

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011年12月, 査読有り

  
• Efficient and Directive Generation of Two Distinct Endoderm Lineages from Human ESCs and iPSCs by Differentiation Stage-Specific SOX17 Transduction

  Kazuo Takayama; Mitsuru Inamura; Kenji Kawabata; Katsuhisa Tashiro; Kazufumi Katayama; Fuminori Sakurai; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi

  PLOS ONE, 2011年07月, 査読有り

  
• Efficient Generation of Hepatoblasts From Human ES Cells and iPS Cells by Transient Overexpression of Homeobox Gene HEX

  Mitsuru Inamura; Kenji Kawabata; Kazuo Takayama; Katsuhisa Tashiro; Fuminori Sakurai; Kazufumi Katayama; Masashi Toyoda; Hidenori Akutsu; Yoshitaka Miyagawa; Hajime Okita; Nobutaka Kiyokawa; Akihiro Umezawa; Takao Hayakawa; Miho K. Furue; Hiroyuki Mizuguchi

  MOLECULAR THERAPY, 2011年02月, 査読有り

  
• Adenovirus Vector-Mediated Efficient Transduction into Human Embryonic and Induced Pluripotent Stem Cells

  Katsuhisa Tashiro; Kenji Kawabata; Mitsuru Inamura; Kazuo Takayama; Norihisa Furukawa; Fuminori Sakurai; Kazufumi Katayama; Takao Hayakawa; Miho Kusuda Furue; Hiroyuki Mizuguchi

  CELLULAR REPROGRAMMING, 2010年10月, 査読有り

  
• The importance of accessory protein variants in the pathogenicity of SARS-CoV-2.

  Sk Sarif Hassan; Pabitra Pal Choudhury; Guy W Dayhoff 2nd; Alaa A A Aljabali; Bruce D Uhal; Kenneth Lundstrom; Nima Rezaei; Damiano Pizzol; Parise Adadi; Amos Lal; Antonio Soares; Tarek Mohamed Abd El-Aziz; Adam M Brufsky; Gajendra Kumar Azad; Samendra P Sherchan; Wagner Baetas-da-Cruz; Kazuo Takayama; Ãngel Serrano-Aroca; Gaurav Chauhan; Giorgio Palu; Yogendra Kumar Mishra; Debmalya Barh; Raner Jośe Santana Silva; Bruno Silva Andrade; Vasco Azevedo; Aristóteles Góes-Neto; Nicolas G Bazan; Elrashdy M Redwan; Murtaza Tambuwala; Vladimir N Uversky

  Archives of biochemistry and biophysics, 2022年03月15日

  
• Establishment of a stable SARS-CoV-2 replicon system for application in high-throughput screening.

  Tomohisa Tanaka; Akatsuki Saito; Tatsuya Suzuki; Yoichi Miyamoto; Kazuo Takayama; Toru Okamoto; Kohji Moriishi

  Antiviral research, 2022年03月07日

  
• Gene Therapy for Neuropsychiatric Disorders: Potential Targets and Tools.

  Seyed Hossein Shahcheraghi; Jamshid Ayatollahi; Marzieh Lotfi; Alaa A A Aljabali; Mazhar S Al-Zoubi; Pritam Kumar Panda; Vijay Mishra; Saurabh Satija; Nitin B Charbe; Ángel Serrano-Aroca; Bojlul Bahar; Kazuo Takayama; Rohit Goyal; Amit Bhatia; Abdulmajeed G Almutary; Abdullah M Alnuqaydan; Yachana Mishra; Poonam Negi; Aaron Courtney; Paul A McCarron; Hamid A Bakshi; Murtaza M Tambuwala

  CNS & neurological disorders drug targets, 2022年03月04日

  
• Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function.

  Sk Sarif Hassan; Kenneth Lundstrom; Ángel Serrano-Aroca; Parise Adadi; Alaa A A Aljabali; Elrashdy M Redwan; Amos Lal; Ramesh Kandimalla; Tarek Mohamed Abd El-Aziz; Pabitra Pal Choudhury; Gajendra Kumar Azad; Samendra P Sherchan; Gaurav Chauhan; Murtaza Tambuwala; Kazuo Takayama; Debmalya Barh; Giorgio Palu; Pallab Basu; Vladimir N Uversky

  International journal of biological macromolecules, 2022年01月01日

  
• Non-Woven Infection Prevention Fabrics Coated with Biobased Cranberry Extracts Inactivate Enveloped Viruses Such as SARS-CoV-2 and Multidrug-Resistant Bacteria.

  Kazuo Takayama; Alberto Tuñón-Molina; Alba Cano-Vicent; Yukiko Muramoto; Takeshi Noda; José Luis Aparicio-Collado; Roser Sabater I Serra; Miguel Martí; Ángel Serrano-Aroca

  International journal of molecular sciences, 2021年11月24日

  

受賞

• 2024年01月05日

  京都大学iPS細胞研究所 CiRA賞

外部資金：科学研究費補助金

• 呼吸器疾患における基底細胞の役割解明

  基盤研究(B)

  小区分90110:生体医工学関連

  京都大学

  高山 和雄

  自 2021年04月01日, 至 2024年03月31日, 交付

  基底細胞;気道;オルガノイド;感染症;臓器チップ;呼吸器感染症;SARS-CoV-2;気管支;iPS細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H03795/
• 光遺伝学的手法による局所的に出現した変異細胞の炎症細胞社会における意義解明

  新学術領域研究(研究領域提案型)

  大阪大学

  高山 和雄

  自 2018年04月01日, 至 2020年03月31日, 完了

  光操作;腸管上皮細胞;慢性炎症;腸炎;光遺伝学;ゲノム編集;１細胞;大腸がん;幹細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PUBLICLY-18H05033/
• 肝障害・肝疾患研究に資するzone特異的肝細胞の創出技術の開発

  挑戦的研究(萌芽)

  大阪大学

  高山 和雄

  自 2017年06月30日, 至 2019年03月31日, 完了

  肝細胞;毒性;薬物代謝;zonation;ヒトiPS細胞;ヒトES細胞;肝障害;胆管上皮細胞;創薬;異物代謝;分化誘導;肝臓;ヒトES/iPS細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K19657/
• 創薬応用を目指した高純度CYP3A4発現ヒトES/iPS由来肝細胞の作製法の開発

  研究活動スタート支援

  大阪大学

  高山 和雄

  自 2015年08月28日, 至 2017年03月31日, 完了

  肝細胞;ヒトES/iPS細胞;薬物代謝;CYP;肝毒性;創薬試験;CYP3A4;ゲノム編集;薬物代謝酵素;相同組換え

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H06365/
• 生体模倣デバイスを用いた腸運動異常を起点とする炎症スバイラルの解析

  基盤研究(B)

  小区分47060:医療薬学関連

  京都大学

  山下 富義

  自 2023年04月01日, 至 2027年03月31日, 交付

  生体模倣デバイス;腸運動;炎症性腸疾患;炎症スパイラル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02650/
• 血管バリアに着目する新しい視点での重症感染症の病態・後遺症発症機構の解明と制御

  基盤研究(B)

  小区分47030:薬系衛生および生物化学関連

  大阪大学

  岡田 欣晃

  自 2023年04月01日, 至 2026年03月31日, 交付

  重症感染症;血管内皮細胞;血管バリア;罹患後症状;治療薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23H02629/
• 生体模倣デバイスを用いた腸運動異常を起点とする炎症スバイラルの解析

  基盤研究(B)

  小区分47060:医療薬学関連

  京都大学

  山下 富義

  自 2023年04月01日, 至 2027年03月31日, 交付

  生体模倣デバイス;腸運動;炎症性腸疾患;炎症スパイラル

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27341/
• 血管バリアに着目する新しい視点での重症感染症の病態・後遺症発症機構の解明と制御

  基盤研究(B)

  小区分47030:薬系衛生および生物化学関連

  大阪大学

  岡田 欣晃

  自 2023年04月01日, 至 2026年03月31日, 交付

  重症感染症;血管内皮細胞;血管バリア;罹患後症状;治療薬

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K27320/

外部資金：その他

• ＳＡＲＳ－ＣｏＶ－２の生活環を再現できるヒト肺モデルの開発と創薬応用 （2020年度分）

  京都発革新的医療技術研究開発助成事業

  自 2020年04月01日, 至 2021年03月31日

  高山　和雄

大学運営

部局運営(役職等)

• 自 2022年04月01日, 至 2026年03月31日

  倫理審査委員会