Basic Information

Faculty

• 医学部

Professional Memberships

• 日本ケミカルバイオロジー研究会
• 日本癌学会
• 日本生化学会
• 日本薬理学会
• 日本解剖学会
• 日本分子生物学会

Academic Degree

• 医学博士(三重大学)

Research History

• Tokyo Medical and Dental University Graduate School of Biomedical Science, 教授

ID,URL

• J-Global ID

  200901083019998291

• External link

  http://www.tmd.ac.jp/mri/mri-end/index.html

researchmap URL

• https://researchmap.jp/read0011076

Research

Research Topics, Overview of the research

• Research Topics

  RNA Splicing, Genetic Diseases, Drug Discovery

• Overview of the research

  He succeeded to visualize tissue-specific and developmental-stage-specific alternative splicing patterns in living nematode worms, and identified the regulatory factors by genomic mapping of the mutants (Nat Methods 2006, Nat Protocols 2010). He further developed the splicing reporter technology, established a dual-color splicing reporter screening system called SPREADD (splicing reporter assay for disease genes with dual-color), applied this to aberrant splicing of IKBKAP exon 20 found in FD patients due to the intronic mutation (IVS20+6T>C), and identified a compound RECTAS that efficiently corrects the mis-splicing of IKBKAP (PNAS 2015). He also developed an anti-virus drug FIT039 targeting host factors required for virus proliferation. FIT039 specifically inhibits CDK9 and suppresses viral transcription of a broad spectrum of DNA viruses including HCMV, HAdV, HBV and HPV without significant adverse effect on mammalian cells (J Clin Invest. 2014, Clin Cancer Res. 2018). The phase1/2a clinical trial of FIT039 for cervical intraepithelial neoplasia (CIN) is under the way in Kyoto University Hospital.

Research Interests

• 抗ウイルス薬
• SRPK
• CREB
• RNAプロセシング
• ケミカルバイオロジー
• Transcriptional Regulation

Research Areas

• Life sciences, Molecular biology
• Nanotechnology/Materials, Molecular biochemistry

Papers

• スフィンゴシン-1-リン酸受容体におけるバイアスドアゴニズム機構

  前田 信太郎; 椎村 祐樹; 浅田 秀基; 平田 邦生; Luo Fangjia; 南後 恵理子; 井上 飛鳥; 青木 淳賢; 岩田 想; 萩原 正敏

  日本生化学会大会プログラム・講演要旨集, Nov. 2021

  
• Successful skipping of abnormal pseudoexon by antisense oligonucleotides in vitro for a patient with beta-propeller protein-associated neurodegeneration

  Mamiko Yamada; Kazuhiro Maeta; Hisato Suzuki; Ryo Kurosawa; Toshiki Takenouchi; Tomonari Awaya; Masahiko Ajiro; Atsuko Takeuchi; Hisahide Nishio; Masatoshi Hagiwara; Fuyuki Miya; Masafumi Matsuo; Kenjiro Kosaki

  Scientific Reports, 18 Mar. 2024

  
• PDIVAS: Pathogenicity predictor for Deep-Intronic Variants causing Aberrant Splicing

  Ryo Kurosawa; Kei Iida; Masahiko Ajiro; Tomonari Awaya; Mamiko Yamada; Kenjiro Kosaki; Masatoshi Hagiwara

  BMC Genomics, 10 Oct. 2023

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• Switching of OAS1 splicing isoforms mitigates SARS-CoV-2 infection

  Kei Iida; Masahiko Ajiro; Yukiko Muramoto; Toru Takenaga; Masatsugu Denawa; Ryo Kurosawa; Takeshi Noda; Masatoshi Hagiwara

  23 Aug. 2021

  
• Screening of factors inducing alveolar type 1 epithelial cells using human pluripotent stem cells.

  Yuko Ohnishi; Atsushi Masui; Takahiro Suezawa; Ryuta Mikawa; Toyohiro Hirai; Masatoshi Hagiwara; Shimpei Gotoh

  Stem cell reports, 09 Apr. 2024

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• 2SE01 Regulatory mechanisms of alternative splicing in metazoans

  Hagiwara M.; Kuroyanagi H.

  Seibutsu Butsuri, 2005

  
• Sfpq-KOマウスをモデルとした骨格筋代謝-筋量制御ネットワークの解析

  細川 元靖; 武内 章英; 谷端 淳; 飯田 慶; 武田 伸一; 萩原 正敏

  日本筋学会学術集会プログラム・抄録集, Aug. 2019

  
• Astrocyte-targeting therapy rescues cognitive impairment caused by neuroinflammation via the Nrf2 pathway

  Akiko Nakano-Kobayashi; Andres Canela; Toru Yoshihara; Masatoshi Hagiwara

  Proceedings of the National Academy of Sciences, 15 Aug. 2023

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• Application of the CDK9 inhibitor FIT-039 for the treatment of KSHV-associated malignancy

  Tetsunori Sakamoto; Masahiko Ajiro; Akira Watanabe; Shingo Matsushima; Keiji Ueda; Masatoshi Hagiwara

  BMC Cancer, 20 Jan. 2023

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• Cryptotanshinone is a candidate therapeutic agent for interstitial lung disease associated with a BRICHOS-domain mutation of SFTPC

  Motoyasu Hosokawa; Ryuta Mikawa; Atsuko Hagiwara; Yukiko Okuno; Tomonari Awaya; Yuki Yamamoto; Senye Takahashi; Haruka Yamaki; Mitsujiro Osawa; Yasuhiro Setoguchi; Megumu K. Saito; Shinji Abe; Toyohiro Hirai; Shimpei Gotoh; Masatoshi Hagiwara

  iScience, Aug. 2023

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• Branchpoints as potential targets of exon-skipping therapies for genetic disorders.

  Hiroaki Ohara; Motoyasu Hosokawa; Tomonari Awaya; Atsuko Hagiwara; Ryo Kurosawa; Yukiya Sako; Megumu Ogawa; Masashi Ogasawara; Satoru Noguchi; Yuichi Goto; Ryosuke Takahashi; Ichizo Nishino; Masatoshi Hagiwara

  Molecular therapy. Nucleic acids, 12 Sep. 2023

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• Identification of the α2 chain of interleukin‐13 receptor as a potential biomarker for predicting castration resistance of prostate cancer using patient‐derived xenograft models

  Takahiro Nagai; Naoki Terada; Masato Fujii; Yasuhisa Nagata; Kozue Nakahara; Shoichiro Mukai; Kosuke Okasho; Yuki Kamiyama; Shusuke Akamatsu; Takashi Kobayashi; Kei Iida; Masatsugu Denawa; Masatoshi Hagiwara; Takahiro Inoue; Osamu Ogawa; Toshiyuki Kamoto

  Cancer Reports, 09 Aug. 2022

  
• iPSC-derived mesenchymal cells that support alveolar organoid development

  Koji Tamai; Kouji Sakai; Haruka Yamaki; Keita Moriguchi; Koichi Igura; Shotaro Maehana; Takahiro Suezawa; Kazuaki Takehara; Masatoshi Hagiwara; Toyohiro Hirai; Shimpei Gotoh

  Cell Reports Methods, Oct. 2022

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• イントロン変異を原因とする筋ジストロフィーの治療

  大原 寛明; 細川 元靖; 粟屋 智就; 高橋 良輔; 小笠原 真志; 野口 悟; 後藤 雄一; 西野 一三; 萩原 正敏

  日本筋学会学術集会プログラム・抄録集, Dec. 2020

  
• Chemical induction of splice-neoantigens attenuates tumor growth in a preclinical model of colorectal cancer

  Shingo Matsushima; Masahiko Ajiro; Kei Iida; Kenji Chamoto; Tasuku Honjo; Masatoshi Hagiwara

  Science Translational Medicine, 30 Nov. 2022

  
• Antagonist of sphingosine 1-phosphate receptor 3 reduces cold injury of rat donor hearts for transplantation

  Eisho Kanemitsu; Xiangdong Zhao; Keiko Iwaisako; Asuka Inoue; Akihide Takeuchi; Shintaro Yagi; Hidetoshi Masumoto; Hiroaki Ohara; Motoyasu Hosokawa; Tomonari Awaya; Junken Aoki; Etsuro Hatano; Shinji Uemoto; Masatoshi Hagiwara

  Translational Research, Nov. 2022

  
• Method for Identifying Sequence Motifs in Pre-miRNAs for Small-Molecule Binding

  Yusuke Takashima; Asako Murata; Kei Iida; Ayako Sugai; Masatoshi Hagiwara; Kazuhiko Nakatani

  ACS CHEMICAL BIOLOGY, Sep. 2022

  
• RNA-seq analysis, targeted long-read sequencing and in silico prediction to unravel pathogenic intronic events and complicated splicing abnormalities in dystrophinopathy

  Mariko Okubo; Satoru Noguchi; Tomonari Awaya; Motoyasu Hosokawa; Nobue Tsukui; Megumu Ogawa; Shinichiro Hayashi; Hirofumi Komaki; Madoka Mori-Yoshimura; Yasushi Oya; Yuji Takahashi; Tetsuhiro Fukuyama; Michinori Funato; Yousuke Hosokawa; Satoru Kinoshita; Tsuyoshi Matsumura; Sadao Nakamura; Azusa Oshiro; Hiroshi Terashima; Tetsuro Nagasawa; Tatsuharu Sato; Yumi Shimada; Yasuko Tokita; Masatoshi Hagiwara; Katsuhisa Ogata; Ichizo Nishino

  Human Genetics, 01 Sep. 2022, Peer-reviewed

  
• Author Correction: Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia.

  Masahiko Ajiro; Tomonari Awaya; Young Jin Kim; Kei Iida; Masatsugu Denawa; Nobuo Tanaka; Ryo Kurosawa; Shingo Matsushima; Saiko Shibata; Tetsunori Sakamoto; Lorenz Studer; Adrian R Krainer; Masatoshi Hagiwara

  Nature communications, 12 Oct. 2021

  
• Safety and Efficacy of FIT039 for Verruca Vulgaris: A Placebo-Controlled, Phase I/II Randomized Controlled Trial.

  Takashi Nomura; Eriko Sumi; Gyohei Egawa; Saeko Nakajima; Eiko Toichi; Nana Inoue; Mami Shibuya; Natsuko Okamoto; Tsuyoshi Mitsuishi; Ryuji Uozumi; Harue Tada; Takayuki Nakagawa; Nobuhiro Kusuba; Aika Okuno; Chihiro Shimizuhira; Makiko Ishikawa; Shiro Tanaka; Masatoshi Hagiwara; Kenji Kabashima

  JID innovations : skin science from molecules to population health, Sep. 2021

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• Posttranscriptional Regulation of Glycoprotein Quality Control in the Endoplasmic Reticulum Is Controlled by the E2 Ub-Conjugating Enzyme UBC6e

  Masatoshi Hagiwara; Jingjing Ling; Paul-Albert Koenig; Hidde L. Ploegh

  MOLECULAR CELL, Sep. 2016, Peer-reviewed

  
• The E2 Ubiquitin-conjugating Enzyme UBE2J1 Is Required for Spermiogenesis in Mice

  Paul-Albert Koenig; Peter K. Nicholls; Florian I. Schmidt; Masatoshi Hagiwara; Takeshi Maruyama; Galit H. Frydman; Nicki Watson; David C. Page; Hidde L. Ploegh

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2014, Peer-reviewed

  
• Synergistic cooperation of PDI family members in peroxiredoxin 4-driven oxidative protein folding

  Yoshimi Sato; Rieko Kojima; Masaki Okumura; Masatoshi Hagiwara; Shoji Masui; Ken-Ichi Maegawa; Masatoshi Saiki; Tomohisa Horibe; Mamoru Suzuki; Kenji Inaba

  Scientific Reports, 2013, Peer-reviewed

  
• Structural Basis of an ERAD Pathway Mediated by the ER-Resident Protein Disulfide Reductase ERdj5

  Masatoshi Hagiwara; Ken-ichi Maegawa; Mamoru Suzuki; Ryo Ushioda; Kazutaka Araki; Yushi Matsumoto; Jun Hoseki; Kazuhiro Nagata; Kenji Inaba

  MOLECULAR CELL, Feb. 2011, Peer-reviewed

  
• Positive Charges of Translocating Polypeptide Chain Retrieve an Upstream Marginal Hydrophobic Segment from the Endoplasmic Reticulum Lumen to the Translocon

  Hidenobu Fujita; Yuichiro Kida; Masatoshi Hagiwara; Fumiko Morimoto; Masao Sakaguchi

  MOLECULAR BIOLOGY OF THE CELL, Jun. 2010, Peer-reviewed

  
• The education system for chemical biology in Japanese universities.

  Hiroyuki Osada; Masatoshi Hagiwara; Kazunobu Toshima; Masaya Imoto

  ACS chemical biology, 19 Sep. 2006

  
• Multicellular modeling of ciliopathy by combining iPS cells and microfluidic airway-on-a-chip technology.

  Naoyuki Sone; Satoshi Konishi; Koichi Igura; Koji Tamai; Satoshi Ikeo; Yohei Korogi; Shuhei Kanagaki; Toshinori Namba; Yuki Yamamoto; Yifei Xu; Kazuhiko Takeuchi; Yuichi Adachi; Toyofumi F Chen-Yoshikawa; Hiroshi Date; Masatoshi Hagiwara; Sachiko Tsukita; Toyohiro Hirai; Yu-Suke Torisawa; Shimpei Gotoh

  Science translational medicine, 07 Jul. 2021

  
• Epigenetic aging in Williams syndrome

  Satoshi Okazaki; Ryo Kimura; Ikuo Otsuka; Kiyotaka Tomiwa; Yasuko Funabiki; Masatoshi Hagiwara; Toshiya Murai; Akitoyo Hishimoto

  Journal of Child Psychology and Psychiatry, 13 Apr. 2022

  
• 低分子スプライス操作化合物による遺伝性疾患の新規治療法開発

  粟屋 智就; 都築 千鶴; 網代 将彦; 齋藤 潤; 萩原 正敏

  脳と発達, May 2019

  
• Modeling of lung phenotype of Hermansky–Pudlak syndrome type I using patient-specific iPSCs

  Takahiro Suezawa; Shuhei Kanagaki; Yohei Korogi; Kazuhisa Nakao; Toyohiro Hirai; Koji Murakami; Masatoshi Hagiwara; Shimpei Gotoh

  Respiratory Research, Dec. 2021

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• Disease modeling of pulmonary fibrosis using human pluripotent stem cell-derived alveolar organoids

  Takahiro Suezawa; Shuhei Kanagaki; Keita Moriguchi; Atsushi Masui; Kazuhisa Nakao; Masayasu Toyomoto; Koji Tamai; Ryuta Mikawa; Toyohiro Hirai; Koji Murakami; Masatoshi Hagiwara; Shimpei Gotoh

  Stem Cell Reports, Nov. 2021

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• イントロン変異を原因とする筋ジストロフィーの治療

  大原 寛明; 細川 元靖; 粟屋 智就; 高橋 良輔; 小笠原 真志; 野口 悟; 後藤 雄一; 西野 一三; 萩原 正敏

  日本筋学会学術集会プログラム・抄録集, Dec. 2020

  
• Core-shell hydrogel microfiber-expanded pluripotent stem cell-derived lung progenitors applicable to lung reconstruction in vivo

  Satoshi Ikeo; Yuki Yamamoto; Kazuhiro Ikeda; Naoyuki Sone; Yohei Korogi; Lucia Tomiyama; Hisako Matsumoto; Toyohiro Hirai; Masatoshi Hagiwara; Shimpei Gotoh

  Biomaterials, Sep. 2021

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• Therapeutic manipulation of IKBKAP mis-splicing with a small molecule to cure familial dysautonomia.

  Masahiko Ajiro; Tomonari Awaya; Young Jin Kim; Kei Iida; Masatsugu Denawa; Nobuo Tanaka; Ryo Kurosawa; Shingo Matsushima; Saiko Shibata; Tetsunori Sakamoto; Rolenz Studer; Adrian R Krainer; Masatoshi Hagiwara

  Nature communications, 23 Jul. 2021

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• Endogenous agonist-bound S1PR3 structure reveals determinants of G protein-subtype bias.

  Shintaro Maeda; Yuki Shiimura; Hidetsugu Asada; Kunio Hirata; Fangjia Luo; Eriko Nango; Nobuo Tanaka; Masayasu Toyomoto; Asuka Inoue; Junken Aoki; So Iwata; Masatoshi Hagiwara

  Science advances, Jun. 2021

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• CDC2-like (CLK) protein kinase inhibition as a novel targeted therapeutic strategy in prostate cancer.

  Simon Uzor; Sean R Porazinski; Ling Li; Bethany Clark; Masahiko Ajiro; Kei Iida; Masatoshi Hagiwara; Abdullah A Alqasem; Claire M Perks; Ian D Wilson; Sebastian Oltean; Michael R Ladomery

  Scientific reports, 12 Apr. 2021

  
• Hydroxypropyl Cyclodextrin Improves Amiodarone-induced Aberrant Lipid Homeostasis of Alveolar Cells.

  Shuhei Kanagaki; Takahiro Suezawa; Keita Moriguchi; Kazuhisa Nakao; Masayasu Toyomoto; Yuki Yamamoto; Koji Murakami; Masatoshi Hagiwara; Shimpei Gotoh

  American journal of respiratory cell and molecular biology, Apr. 2021

  
• S1PR3-G12-biased agonist ALESIA targets cancer metabolism and promotes glucose starvation.

  Masayasu Toyomoto; Asuka Inoue; Kei Iida; Masatsugu Denawa; Isao Kii; Francois Marie Ngako Kadji; Takayuki Kishi; Dohyun Im; Tatsuro Shimamura; Hiroshi Onogi; Suguru Yoshida; So Iwata; Junken Aoki; Takamitsu Hosoya; Masatoshi Hagiwara

  Cell chemical biology, 02 Feb. 2021

  
• Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition.

  Shuhei Kanagaki; Satoshi Ikeo; Takahiro Suezawa; Yuki Yamamoto; Masahide Seki; Toyohiro Hirai; Masatoshi Hagiwara; Yutaka Suzuki; Shimpei Gotoh

  Stem cells (Dayton, Ohio), Feb. 2021

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• Therapeutics potentiating microglial p21-Nrf2 axis can rescue neurodegeneration caused by neuroinflammation.

  A Nakano-Kobayashi; A Fukumoto; A Morizane; D T Nguyen; T M Le; K Hashida; T Hosoya; R Takahashi; J Takahashi; O Hori; M Hagiwara

  Science advances, Nov. 2020

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• Identification of Qk as a Glial Precursor Cell Marker that Governs the Fate Specification of Neural Stem Cells to a Glial Cell Lineage.

  Akihide Takeuchi; Yuji Takahashi; Kei Iida; Motoyasu Hosokawa; Koichiro Irie; Mikako Ito; J B Brown; Kinji Ohno; Kinichi Nakashima; Masatoshi Hagiwara

  Stem cell reports, 13 Oct. 2020, Peer-reviewed

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• Mechanism-Based Personalized Medicine for Cystic Fibrosis by Suppressing Pseudo Exon Inclusion.

  Saiko Shibata; Masahiko Ajiro; Masatoshi Hagiwara

  Cell chemical biology, 07 Sep. 2020, Peer-reviewed

  
• Integrated DNA methylation analysis reveals a potential role for ANKRD30B in Williams syndrome.

  Ryo Kimura; Roy Lardenoije; Kiyotaka Tomiwa; Yasuko Funabiki; Masatoshi Nakata; Shiho Suzuki; Tomonari Awaya; Takeo Kato; Shin Okazaki; Toshiya Murai; Toshio Heike; Bart P F Rutten; Masatoshi Hagiwara

  Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, Sep. 2020, Peer-reviewed

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• Multilateral Bioinformatics Analyses Reveal the Function-Oriented Target Specificities and Recognition of the RNA-Binding Protein SFPQ.

  Kei Iida; Masatoshi Hagiwara; Akihide Takeuchi

  iScience, 24 Jul. 2020, Peer-reviewed

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• RNA binding activity of HSV-2 ICP27 protein

  Hidenobu Kawamura; Takayuki Nojima; Takako Oshiro-Ideue; Naoyuki Kataoka; Masatoshi Hagiwara

  RNA & DISEASE, 17 Jun. 2020, Peer-reviewed

  
• Different effects of methylphenidate and atomoxetine on the behavior and brain transcriptome of zebrafish.

  Shiho Suzuki; Ryo Kimura; Shingo Maegawa; Masatoshi Nakata; Masatoshi Hagiwara

  Molecular brain, 06 May 2020, Peer-reviewed

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• Dysregulation of the oxytocin receptor gene in Williams syndrome.

  Ryo Kimura; Kiyotaka Tomiwa; Ryo Inoue; Shiho Suzuki; Masatoshi Nakata; Tomonari Awaya; Takeo Kato; Shin Okazaki; Toshio Heike; Masatoshi Hagiwara

  Psychoneuroendocrinology, May 2020, Peer-reviewed

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• High-resolution imaging mass spectrometry combined with transcriptomic analysis identified a link between fatty acid composition of phosphatidylinositols and the immune checkpoint pathway at the primary tumour site of breast cancer.

  Masahiro Kawashima; Mariko Tokiwa; Tomomi Nishimura; Yukiko Kawata; Masahiro Sugimoto; Tatsuki R Kataoka; Takaki Sakurai; Keiko Iwaisako; Eiji Suzuki; Masatoshi Hagiwara; Adrian L Harris; Masakazu Toi

  British journal of cancer, Jan. 2020, Peer-reviewed

  
• MicroRNA profiling in adults with high-functioning autism spectrum disorder.

  Masatoshi Nakata; Ryo Kimura; Yasuko Funabiki; Tomonari Awaya; Toshiya Murai; Masatoshi Hagiwara

  Molecular brain, 21 Oct. 2019, Peer-reviewed

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• An epigenetic biomarker for adult high-functioning autism spectrum disorder.

  Ryo Kimura; Masatoshi Nakata; Yasuko Funabiki; Shiho Suzuki; Tomonari Awaya; Toshiya Murai; Masatoshi Hagiwara

  Scientific reports, 20 Sep. 2019, Peer-reviewed

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• The efficacy of a cyclin dependent kinase 9 (CDK9) inhibitor, FIT039, on verruca vulgaris: study protocol for a randomized controlled trial.

  Takashi Nomura; Eriko Sumi; Gyohei Egawa; Saeko Nakajima; Eiko Toichi; Ryuji Uozumi; Harue Tada; Takayuki Nakagawa; Masatoshi Hagiwara; Kenji Kabashima

  Trials, 09 Aug. 2019, Peer-reviewed

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• In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids.

  Yohei Korogi; Shimpei Gotoh; Satoshi Ikeo; Yuki Yamamoto; Naoyuki Sone; Koji Tamai; Satoshi Konishi; Tadao Nagasaki; Hisako Matsumoto; Isao Ito; Toyofumi F Chen-Yoshikawa; Hiroshi Date; Masatoshi Hagiwara; Isao Asaka; Akitsu Hotta; Michiaki Mishima; Toyohiro Hirai

  Stem cell reports, 09 Jul. 2019, Peer-reviewed

  
• Integrative network analysis reveals biological pathways associated with Williams syndrome

  Ryo Kimura; Vivek Swarup; Kiyotaka Tomiwa; Michael J. Gandal; Neelroop N. Parikshak; Yasuko Funabiki; Masatoshi Nakata; Tomonari Awaya; Takeo Kato; Kei Iida; Shin Okazaki; Kanae Matsushima; Toshihiro Kato; Toshiya Murai; Toshio Heike; Daniel H. Geschwind; Masatoshi Hagiwara

  Journal of Child Psychology and Psychiatry, May 2019, Peer-reviewed

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• Verification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model.

  Jose Ichisima; Naoya M Suzuki; Bumpei Samata; Tomonari Awaya; Jun Takahashi; Masatoshi Hagiwara; Tatsutoshi Nakahata; Megumu K Saito

  Journal of human genetics, May 2019, Peer-reviewed

  
• Loss of RNA-Binding Protein Sfpq Causes Long-Gene Transcriptopathy in Skeletal Muscle and Severe Muscle Mass Reduction with Metabolic Myopathy.

  Motoyasu Hosokawa; Akihide Takeuchi; Jun Tanihata; Kei Iida; Shin'ichi Takeda; Masatoshi Hagiwara

  iScience, 29 Mar. 2019, Peer-reviewed

  
• In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids.

  Yohei Korogi; Shimpei Gotoh; Satoshi Ikeo; Yuki Yamamoto; Naoyuki Sone; Koji Tamai; Satoshi Konishi; Tadao Nagasaki; Hisako Matsumoto; Isao Ito; Toyofumi F Chen-Yoshikawa; Hiroshi Date; Masatoshi Hagiwara; Isao Asaka; Akitsu Hotta; Michiaki Mishima; Toyohiro Hirai

  Stem cell reports, 05 Mar. 2019, Peer-reviewed

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• Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency.

  Bertrand Boisson; Yoshitaka Honda; Masahiko Ajiro; Jacinta Bustamante; Matthieu Bendavid; Andrew R Gennery; Yuri Kawasaki; Jose Ichishima; Mitsujiro Osawa; Hiroshi Nihira; Takeshi Shiba; Takayuki Tanaka; Maya Chrabieh; Benedetta Bigio; Hong Hur; Yuval Itan; Yupu Liang; Satoshi Okada; Kazushi Izawa; Ryuta Nishikomori; Osamu Ohara; Toshio Heike; Laurent Abel; Anne Puel; Megumu K Saito; Jean-Laurent Casanova; Masatoshi Hagiwara; Takahiro Yasumi

  The Journal of clinical investigation, 01 Feb. 2019, Peer-reviewed

  
• Safety and Plasma Concentrations of a Cyclin-dependent Kinase 9 (CDK9) Inhibitor, FIT039, Administered by a Single Adhesive Skin Patch Applied on Normal Skin and Cutaneous Warts.

  Sumi E; Nomura T; Asada R; Uozumi R; Tada H; Amino Y; Sawada T; Yonezawa A; Hagiwara M; Kabashima K

  Clinical drug investigation, Oct. 2018, Peer-reviewed

  
• Necrostatin-7 suppresses RANK-NFATc1 signaling and attenuates macrophage to osteoclast differentiation.

  Hiroaki Fuji; Saori Ohmae; Naruto Noma; Masatoshi Takeiri; Hideto Yasutomi; Kazuya Izumi; Moe Ito; Masayasu Toyomoto; Soichiro Iwaki; Kenji Takemoto; Satoru Seo; Kojiro Taura; Shigeaki Hida; Mineyoshi Aoyama; Yasushi Ishihama; Masatoshi Hagiwara; Norihiko Takeda; Etsuro Hatano; Keiko Iwaisako; Shinji Uemoto; Masataka Asagiri

  Biochemical and biophysical research communications, 05 Sep. 2018, Peer-reviewed

  
• CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia.

  Ajiro M; Sakai H; Onogi H; Yamamoto M; Sumi E; Sawada T; Nomura T; Kabashima K; Hosoya T; Hagiwara M

  Clinical cancer research : an official journal of the American Association for Cancer Research, Sep. 2018, Peer-reviewed

  
• The 40th Anniversary of the Congenital Anomaly Research Center, Kyoto University Graduate School of Medicine

  Shigehito Yamada; Momoko Nagai; Masatoshi Hagiwara

  The Anatomical Record, Jun. 2018, Peer-reviewed

  
• Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain.

  Akihide Takeuchi; Kei Iida; Toshiaki Tsubota; Motoyasu Hosokawa; Masatsugu Denawa; J B Brown; Kensuke Ninomiya; Mikako Ito; Hiroshi Kimura; Takaya Abe; Hiroshi Kiyonari; Kinji Ohno; Masatoshi Hagiwara

  Cell reports, 01 May 2018, Peer-reviewed

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• Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions

  Suguru Yoshida; Kimiyuki Kanno; Isao Kii; Yoshihiro Misawa; Masatoshi Hagiwara; Takamitsu Hosoya

  Chemical Communications, 2018, Peer-reviewed

  
• Williams-Beuren Syndrome as a Potential Risk Factor for Burkitt Lymphoma.

  Kimura R; Ishii Y; Tomiwa K; Awaya T; Nakata M; Kato T; Okazaki S; Heike T; Hagiwara M

  Frontiers in genetics, 2018, Peer-reviewed

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• Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity

  Kosuke Kawaguchi; Eiji Suzuki; Mariko Nishie; Isao Kii; Tatsuki R. Kataoka; Masahiro Hirata; Masashi Inoue; Fengling Pu; Keiko Iwaisako; Moe Tsuda; Ayane Yamaguchi; Hironori Haga; Masatoshi Hagiwara; Masakazu Toi

  CANCER IMMUNOLOGY IMMUNOTHERAPY, Sep. 2017, Peer-reviewed

  
• RBM24 promotes U1 snRNP recognition of the mutated 5 ' splice site in the IKBKAP gene of familial dysautonomia

  Kenji Ohe; Mayumi Yoshida; Akiko Nakano-Kobayashi; Motoyasu Hosokawa; Yukiya Sako; Maki Sakuma; Yukiko Okuno; Tomomi Usui; Kensuke Ninomiya; Takayuki Nojima; Naoyuki Kataoka; Masatoshi Hagiwara

  RNA, Sep. 2017, Peer-reviewed

  
• Prenatal neurogenesis induction therapy normalizes brain structure and function in Down syndrome mice

  Akiko Nakano-Kobayashi; Tomonari Awaya; Isao Kii; Yuto Sumida; Yukiko Okuno; Suguru Yoshida; Tomoe Sumida; Haruhisa Inoue; Takamitsu Hosoya; Masatoshi Hagiwara

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Sep. 2017, Peer-reviewed

  
• Synthetic ligand promotes gene expression by affecting GC sequence in promoter

  Saki Matsumoto; Kei Iida; Asako Murata; Masatsugu Denawa; Masatoshi Hagiwara; Kazuhiko Nakatani

  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, Aug. 2017, Peer-reviewed

  
• Retinoid derivative Tp80 exhibits anti-hepatitis C virus activity through restoration of GI-GPx expression

  Bao Ngoc Nguyen; Yukiko Okuno; Masahiko Ajiro; Kei Iida; Masatsugu Denawa; Makoto Yamamoto; Naoya Sakamoto; Hiroyuki Kagechika; Masatoshi Hagiwara

  JOURNAL OF MEDICAL VIROLOGY, Jul. 2017, Peer-reviewed

  
• Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy

  Yukiya Sako; Kensuke Ninomiya; Yukiko Okuno; Masayasu Toyomoto; Atsushi Nishida; Yuka Koike; Kenji Ohe; Isao Kii; Suguru Yoshida; Naohiro Hashimoto; Takamitsu Hosoya; Masafumi Matsuo; Masatoshi Hagiwara

  SCIENTIFIC REPORTS, May 2017, Peer-reviewed

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• In vitro expansion of mouse primordial germ cell-like cells recapitulates an epigenetic blank slate.

  Ohta H; Kurimoto K; Okamoto I; Nakamura T; Yabuta Y; Miyauchi H; Yamamoto T; Okuno Y; Hagiwara M; Shirane K; Sasaki H; Saitou M

  The EMBO journal, May 2017, Peer-reviewed

  
• Actin-binding protein coronin 1A controls osteoclastic bone resorption by regulating lysosomal secretion of cathepsin K

  Saori Ohmae; Naruto Noma; Masayasu Toyomoto; Masahiro Shinohara; Masatoshi Takeiri; Hiroaki Fuji; Kenji Takemoto; Keiko Iwaisako; Tomoko Fujita; Norihiko Takeda; Makoto Kawatani; Mineyoshi Aoyama; Masatoshi Hagiwara; Yasushi Ishihama; Masataka Asagiri

  SCIENTIFIC REPORTS, Mar. 2017, Peer-reviewed

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• Transport Granules Bound with Nuclear Cap Binding Protein and Exon Junction Complex Are Associated with Microtubules and Spatially Separated from eIF4E Granules and P Bodies in Human Neuronal Processes.

  Dan O Wang; Kensuke Ninomiya; Chihiro Mori; Ayako Koyama; Martine Haan; Makoto Kitabatake; Masatoshi Hagiwara; Kazuhiro Chida; Shin-Ichiro Takahashi; Mutsuhito Ohno; Naoyuki Kataoka

  Frontiers in molecular biosciences, 2017, Peer-reviewed

  
• Cancer-specific mutations in p53 induce the translation of 160p53 promoting tumorigenesis

  Marco M. Candeias; Masatoshi Hagiwara; Michiyuki Matsuda

  EMBO REPORTS, Nov. 2016, Peer-reviewed

  
• Inhibitory effect of CDK9 inhibitor FIT-039 on hepatitis B virus propagation

  Tomohisa Tanaka; Kaori Okuyama-Dobashi; Shuko Murakami; Wenjia Chen; Toru Okamoto; Keiji Ueda; Takamitsu Hosoya; Yoshiharu Matsuura; Akihide Ryo; Yasuhito Tanaka; Masatoshi Hagiwara; Kohji Moriishi

  ANTIVIRAL RESEARCH, Sep. 2016, Peer-reviewed

  
• Selective inhibition of the kinase DYRK1A by targeting its folding process

  Isao Kii; Yuto Sumida; Toshiyasu Goto; Rie Sonamoto; Yukiko Okuno; Suguru Yoshida; Tomoe Kato-Sumida; Yuka Koike; Minako Abe; Yosuke Nonaka; Teikichi Ikura; Nobutoshi Ito; Hiroshi Shibuya; Takamitsu Hosoya; Masatoshi Hagiwara

  NATURE COMMUNICATIONS, Apr. 2016, Peer-reviewed

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• SRPK1/CK2阻害活性を有する新規血管新生阻害局所薬

  諸岡 諭; 伊藤 暢聡; 細谷 孝充; 野田 航介; 石田 晋; 萩原 正敏; 吉村 長久

  日本眼科学会雑誌, Dec. 2015

  
• Selective inhibition of HIV-1 replication by the CDK9 inhibitor FIT-039

  Mika Okamoto; Akemi Hidaka; Masaaki Toyama; Takamitsu Hosoya; Makoto Yamamoto; Masatoshi Hagiwara; Masanori Baba

  ANTIVIRAL RESEARCH, Nov. 2015, Peer-reviewed

  
• Deciphering targeting rules of splicing modulator compounds: case of TG003

  Maki Sakuma; Kei Iida; Masatoshi Hagiwara

  BMC MOLECULAR BIOLOGY, Sep. 2015, Peer-reviewed

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• Na, K-ATPase alpha 3 is a death target of Alzheimer patient amyloid-beta assembly

  Takayuki Ohnishi; Masako Yanazawa; Tomoya Sasahara; Yasuki Kitamura; Hidekazu Hiroaki; Yugo Fukazawa; Isao Kii; Takashi Nishiyama; Akiyoshi Kakita; Hiroyuki Takeda; Akihide Takeuchi; Yoshie Arai; Akane Ito; Hitomi Komura; Hajime Hirao; Kaori Satomura; Masafumi Inoue; Shin-ichi Muramatsu; Ko Matsui; Mari Tada; Michio Sato; Eri Saijo; Yoshiki Shigemitsu; Satoko Sakai; Yoshitaka Umetsu; Natsuko Goda; Naomi Takino; Hitoshi Takahashi; Masatoshi Hagiwara; Tatsuya Sawasaki; Genji Iwasaki; Yu Nakamura; Yo-ichi Nabeshima; David B. Teplow; Minako Hoshi

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Aug. 2015, Peer-reviewed

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• Identification of a DYRK1A Inhibitor that Induces Degradation of the Target Kinase using Co-chaperone CDC37 fused with Luciferase nanoKAZ

  Rie Sonamoto; Isao Kii; Yuka Koike; Yuto Sumida; Tomoe Kato-Sumida; Yukiko Okuno; Takamitsu Hosoya; Masatoshi Hagiwara

  SCIENTIFIC REPORTS, Aug. 2015, Peer-reviewed

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• Identification of a Dual Inhibitor of SRPK1 and CK2 That Attenuates Pathological Angiogenesis of Macular Degeneration in Mice

  Satoshi Morooka; Mitsuteru Hoshina; Isao Kii; Takayoshi Okabe; Hirotatsu Kojima; Naoko Inoue; Yukiko Okuno; Masatsugu Denawa; Suguru Yoshida; Junichi Fukuhara; Kensuke Ninomiya; Teikichi Ikura; Toshio Furuya; Tetsuo Nagano; Kousuke Noda; Susumu Ishida; Takamitsu Hosoya; Nobutoshi Ito; Nagahisa Yoshimura; Masatoshi Hagiwara

  MOLECULAR PHARMACOLOGY, Aug. 2015, Peer-reviewed

  
• Design and synthesis of a potent inhibitor of class 1 DYRK kinases as a suppressor of adipogenesis

  So Masaki; Isao Kii; Yuto Sumida; Tomoe Kato-Sumida; Yasushi Ogawa; Nobutoshi Ito; Mitsuhiro Nakamura; Rie Sonamoto; Naoyuki Kataoka; Takamitsu Hosoya; Masatoshi Hagiwara

  BIOORGANIC & MEDICINAL CHEMISTRY, Aug. 2015, Peer-reviewed

  
• Rectifier of aberrant mRNA splicing recovers tRNA modification in familial dysautonomia

  Mayumi Yoshida; Naoyuki Kataoka; Kenjyo Miyauchi; Kenji Ohe; Kei Iida; Suguru Yoshida; Takayuki Nojima; Yukiko Okuno; Hiroshi Onogi; Tomomi Usui; Akihide Takeuchi; Takamitsu Hosoya; Tsutomu Suzuki; Masatoshi Hagiwaraa

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Mar. 2015, Peer-reviewed

  
• RBFOX and SUP-12 sandwich a G base to cooperatively regulate tissue-specific splicing

  Kanako Kuwasako; Mari Takahashi; Satoru Unzai; Kengo Tsuda; Seiko Yoshikawa; Fahu He; Naohiro Kobayashi; Peter Guentert; Mikako Shirouzu; Takuhiro Ito; Akiko Tanaka; Shigeyuki Yokoyama; Masatoshi Hagiwara; Hidehito Kuroyanagi; Yutaka Muto

  NATURE STRUCTURAL & MOLECULAR BIOLOGY, Sep. 2014, Peer-reviewed

  
• CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses

  Makoto Yamamoto; Hiroshi Onogi; Isao Kii; Suguru Yoshida; Kei Iida; Hiroyuki Sakai; Minako Abe; Toshiaki Tsubota; Nobutoshi Ito; Takamitsu Hosoya; Masatoshi Hagiwara

  JOURNAL OF CLINICAL INVESTIGATION, Aug. 2014, Peer-reviewed

  
• Alleviation of behavioral hypersensitivity in mouse models of inflammatory pain with two structurally different casein kinase 1 (CK1) inhibitors

  Takashi Kurihara; Eri Sakurai; Masayasu Toyomoto; Isao Kii; Daisuke Kawamoto; Toshihide Asada; Tsutomu Tanabe; Megumu Yoshimura; Masatoshi Hagiwara; Atsuro Miyata

  MOLECULAR PAIN, Mar. 2014, Peer-reviewed

  
• Topical Antiangiogenic SRPK1 Inhibitors Reduce Choroidal Neovascularization in Rodent Models of Exudative AMD

  Melissa V. Gammons; Oleg Fedorov; David Ivison; Chunyun Du; Tamsyn Clark; Claire Hopkins; Masatoshi Hagiwara; Andrew D. Dick; Russell Cox; Steven J. Harper; Jules C. Hancox; Stefan Knapp; David O. Bates

  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, Sep. 2013, Peer-reviewed

  
• Inhibition of DYRK1A destabilizes EGFR and reduces EGFR-dependent glioblastoma growth

  Natividad Pozo; Cristina Zahonero; Paloma Fernandez; Jose M. Linares; Angel Ayuso; Masatoshi Hagiwara; Angel Perez; Jose R. Ricoy; Aurelio Hernandez-Lain; Juan M. Sepulveda; Pilar Sanchez-Gomez

  JOURNAL OF CLINICAL INVESTIGATION, Jun. 2013, Peer-reviewed

  
• Position-dependent and neuron-specific splicing regulation by the CELF family RNA-binding protein UNC-75 in Caenorhabditis elegans

  Hidehito Kuroyanagi; Yohei Watanabe; Yutaka Suzuki; Masatoshi Hagiwara

  Nucleic Acids Research, Apr. 2013, Peer-reviewed

  
• CELF Family RNA-Binding Protein UNC-75 Regulates Two Sets of Mutually Exclusive Exons of the unc-32 Gene in Neuron-Specific Manners in Caenorhabditis elegans

  Hidehito Kuroyanagi; Yohei Watanabe; Masatoshi Hagiwara

  PLoS Genetics, Feb. 2013, Peer-reviewed

  
• Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization

  Zhenyu Dong; Kousuke Noda; Atsuhiro Kanda; Junichi Fukuhara; Ryo Ando; Miyuki Murata; Wataru Saito; Masatoshi Hagiwara; Susumu Ishida

  MOLECULAR VISION, Mar. 2013, Peer-reviewed

  
• hDbr1 is a nucleocytoplasmic shuttling protein with a protein phosphatase-like motif essential for debranching activity.

  Naoyuki Kataoka; Izumi Dobashi; Masatoshi Hagiwara; Mutsuhito Ohno

  Scientific reports, 2013, Peer-reviewed

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• Identification of Novel N-(Morpholine-4-Carbonyloxy) Amidine Compounds as Potent Inhibitors against Hepatitis C Virus Replication

  Akiko Kusano-Kitazume; Naoya Sakamoto; Yukiko Okuno; Yuko Sekine-Osajima; Mina Nakagawa; Sei Kakinuma; Kei Kiyohashi; Sayuri Nitta; Miyako Murakawa; Seishin Azuma; Yuki Nishimura-Sakurai; Masatoshi Hagiwara; Mamoru Watanabe

  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Mar. 2012, Peer-reviewed

  
• The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2

  Noriko Saitoh; Chiyomi Sakamoto; Masatoshi Hagiwara; Lourdes T. Agredano-Moreno; Luis Felipe Jimenez-Garcia; Mitsuyoshi Nakao

  MOLECULAR BIOLOGY OF THE CELL, Mar. 2012, Peer-reviewed

  
• Muscle-Specific Splicing Factors ASD-2 and SUP-12 Cooperatively Switch Alternative Pre-mRNA Processing Patterns of the ADF/Cofilin Gene in Caenorhabditis elegans

  Genta Ohno; Kanako Ono; Marina Togo; Yohei Watanabe; Shoichiro Ono; Masatoshi Hagiwara; Hidehito Kuroyanagi

  PLoS Genetics, Oct. 2012, Peer-reviewed

  
• WT1 Mutants Reveal SRPK1 to Be a Downstream Angiogenesis Target by Altering VEGF Splicing

  Elianna M. Amin; Sebastian Oltean; Jing Hua; Melissa V. R. Gammons; Maryam Hamdollah-Zadeh; Gavin I. Welsh; Man-Kim Cheung; Lan Ni; Satoru Kase; Emma S. Renne; Kirsty E. Symonds; Dawid G. Nowak; Brigitte Royer-Pokora; Moin A. Saleem; Masatoshi Hagiwara; Valerie A. Schumacher; Steven J. Harper; David R. Hinton; David O. Bates; Michael R. Ladomery

  CANCER CELL, Dec. 2011, Peer-reviewed

  
• Stress-responsive maturation of Clk1/4 pre-mRNAs promotes phosphorylation of SR splicing factor

  Kensuke Ninomiya; Naoyuki Kataoka; Masatoshi Hagiwara

  JOURNAL OF CELL BIOLOGY, Oct. 2011, Peer-reviewed

  
• Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNA

  Naoyuki Kataoka; Michael D. Diem; Mayumi Yoshida; Chihiro Hatai; Izumi Dobashi; Gideon Dreyfuss; Masatoshi Hagiwara; Mutsuhito Ohno

  SCIENTIFIC REPORTS, Sep. 2011, Peer-reviewed

  
• The Kinase Inhibitor SFV785 Dislocates Dengue Virus Envelope Protein from the Replication Complex and Blocks Virus Assembly

  Azlinda Anwar; Takamitsu Hosoya; Kok Mun Leong; Hiroshi Onogi; Yukiko Okuno; Toshiyuki Hiramatsu; Hiroko Koyama; Masaaki Suzuki; Masatoshi Hagiwara; Mariano A. Garcia-Blanco

  PLOS ONE, Aug. 2011, Peer-reviewed

  
• Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing

  Mansour Debdab; Francois Carreaux; Steven Renault; Meera Soundararajan; Oleg Fedorov; Panagis Filippakopoulos; Olivier Lozach; Lucie Babault; Tania Tahtouh; Blandine Baratte; Yasushi Ogawa; Masatoshi Hagiwara; Andreas Eisenreich; Ursula Rauch; Stefan Knapp; Laurent Meijer; Jean-Pierre Bazureau

  JOURNAL OF MEDICINAL CHEMISTRY, Jun. 2011, Peer-reviewed

  
• Chemical treatment enhances skipping of a mutated exon in the dystrophin gene

  Atsushi Nishida; Naoyuki Kataoka; Yasuhiro Takeshima; Mariko Yagi; Hiroyuki Awano; Mitsunori Ota; Kyoko Itoh; Masatoshi Hagiwara; Masafumi Matsuo

  NATURE COMMUNICATIONS, May 2011, Peer-reviewed

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• Fgfr1 and the IIIc Isoform of Fgfr2 Play Critical Roles in the Metanephric Mesenchyme Mediating Early Inductive Events in Kidney Development

  Sunder Sims-Lucas; Brian Cusack; Jeffrey Baust; Veraragavan P. Eswarakumar; Hagiwara Masatoshi; Akihide Takeuchi; Carlton M. Bates

  DEVELOPMENTAL DYNAMICS, Jan. 2011, Peer-reviewed

  
• Development of a novel selective inhibitor of the Down syndrome-related kinase Dyrk1A

  Yasushi Ogawa; Yosuke Nonaka; Toshiyasu Goto; Eriko Ohnishi; Toshiyuki Hiramatsu; Isao Kii; Miyo Yoshida; Teikichi Ikura; Hiroshi Onogi; Hiroshi Shibuya; Takamitsu Hosoya; Nobutoshi Ito; Masatoshi Hagiwara

  NATURE COMMUNICATIONS, Oct. 2010, Peer-reviewed

  
• Visualization and genetic analysis of alternative splicing regulation in vivo using fluorescence reporters in transgenic Caenorhabditis elegans

  Hidehito Kuroyanagi; Genta Ohno; Hiroaki Sakane; Hiroyuki Maruoka; Masatoshi Hagiwara

  NATURE PROTOCOLS, Sep. 2010, Peer-reviewed

  
• Inhibition of Hepatitis C Virus Replication by a Specific Inhibitor of Serine-Arginine-Rich Protein Kinase

  Yuko Karakama; Naoya Sakamoto; Yasuhiro Itsui; Mina Nakagawa; Megumi Tasaka-Fujita; Yuki Nishimura-Sakurai; Sei Kakinuma; Masaya Oooka; Seishin Azuma; Kiichiro Tsuchiya; Hiroshi Onogi; Masatoshi Hagiwara; Mamoru Watanabe

  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, Aug. 2010, Peer-reviewed

  
• Splicing Reporter Mice Revealed the Evolutionally Conserved Switching Mechanism of Tissue-Specific Alternative Exon Selection

  Akihide Takeuchi; Motoyasu Hosokawa; Takayuki Nojima; Masatoshi Hagiwara

  PLOS ONE, Jun. 2010, Peer-reviewed

  
• Regulation of Vascular Endothelial Growth Factor (VEGF) Splicing from Pro-angiogenic to Anti-angiogenic Isoforms A NOVEL THERAPEUTIC STRATEGY FOR ANGIOGENESIS

  Dawid G. Nowak; Elianna Mohamed Amin; Emma S. Rennel; Coralie Hoareau-Aveilla; Melissa Gammons; Gopinath Damodoran; Masatoshi Hagiwara; Steven J. Harper; Jeanette Woolard; Michael R. Ladomery; David O. Bates

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2010, Peer-reviewed

  
• Strain-promoted double-click reaction for chemical modification of azido-biomolecules

  Isao Kii; Akira Shiraishi; Toshiyuki Hiramatsu; Takeshi Matsushita; Hidehiro Uekusa; Suguru Yoshida; Makoto Yamamoto; Akira Kudo; Masatoshi Hagiwara; Takamitsu Hosoya

  ORGANIC & BIOMOLECULAR CHEMISTRY, 2010, Peer-reviewed

  
• Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing

  Takayuki Nojima; Takako Oshiro-Ideue; Hiroto Nakanoya; Hidenobu Kawamura; Tomomi Morimoto; Yasushi Kawaguchi; Naoyuki Kataoka; Masatoshi Hagiwara

  NUCLEIC ACIDS RESEARCH, Oct. 2009, Peer-reviewed

  
• Akt2 Regulation of Cdc2-Like Kinases (Clk/Sty), Serine/Arginine-Rich (SR) Protein Phosphorylation, and Insulin-Induced Alternative Splicing of PKC beta II Messenger Ribonucleic Acid

  Kun Jiang; Niketa A. Patel; James E. Watson; Hercules Apostolatos; Eden Kleiman; Olivia Hanson; Masatoshi Hagiwara; Denise R. Cooper

  ENDOCRINOLOGY, May 2009, Peer-reviewed

  
• Combination of Clk family kinase and SRp75 modulates alternative splicing of Adenovirus E1A

  Jun-ichiro Yomoda; Michiko Muraki; Naoyuki Kataoka; Takamitsu Hosoya; Masaaki Suzuki; Masatoshi Hagiwara; Hiroshi Kimura

  GENES TO CELLS, Mar. 2008, Peer-reviewed

  
• STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo

  Genta Ohno; Masatoshi Hagiwara; Hidehito Kuroyanagi

  GENES & DEVELOPMENT, Feb. 2008, Peer-reviewed

  
• The Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo

  Hidehito Kuroyanagi; Genta Ohno; Shohel Mitani; Masatoshi Hagiwara

  MOLECULAR AND CELLULAR BIOLOGY, Dec. 2007, Peer-reviewed

  
• Spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA

  Daisuke Kaida; Hajime Motoyoshi; Etsu Tashiro; Takayuki Nojima; Masatoshi Hagiwara; Ken Ishigami; Hidenori Watanabe; Takeshi Kitahara; Tatsuhiko Yoshida; Hidenori Nakajima; Tokio Tani; Sueharu Horinouchi; Minoru Yoshida

  NATURE CHEMICAL BIOLOGY, Sep. 2007, Peer-reviewed

  
• Introns play an essential role in splicing-dependent formation of the exon junction complex

  Takashi Ideue; Yasnory T. F. Sasaki; Masatoshi Hagiwara; Tetsuro Hirose

  GENES & DEVELOPMENT, Aug. 2007, Peer-reviewed

  
• The interaction between cap-binding complex and RNA export factor is required for intronless mRNA export

  Takayuki Nojima; Tetsuro Hirose; Hiroshi Kimura; Masatoshi Hagiwara

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2007, Peer-reviewed

  
• Shortened life spans of biotech pioneer patents in Japan: a lesson from the DNA chip

  Tomomi Aida; Atsuo Konishi; Masatoshi Hagiwara; Kazunori Hashimoto

  NATURE BIOTECHNOLOGY, May 2007, Peer-reviewed

  
• Transgenic alternative-splicing reporters reveal tissue-specific expression profiles and regulation mechanisms in vivo

  Hidehito Kuroyanagi; Tetsuo Kobayashi; Shohei Mitani; Masatoshi Hagiwara

  NATURE METHODS, Nov. 2006, Peer-reviewed

  
• A novel histone exchange factor, protein phosphatase 2C gamma mediates the exchange and dephosphorylation of H2A-H2B

  Hiroshi Kimura; Nanako Takizawa; Eric Allemand; Tetsuya Hori; Francisco J. Iborra; Naohito Nozaki; Michiko Muraki; Masatoshi Hagiwara; Adrian R. Krainer; Tatsuo Fukagawa; Katsuya Okawa

  JOURNAL OF CELL BIOLOGY, Nov. 2006, Peer-reviewed

  
• A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes

  Kazuhiro Wada; Jason T. Howard; Patrick McConnell; Osceola Whitney; Thierry Lints; Miriam V. Rivas; Haruhito Horita; Michael A. Patterson; Stephanie A. White; Constance Scharff; Sebastian Haesler; Shengli Zhao; Hironobu Sakaguchi; Masatoshi Hagiwara; Toshiyuki Shiraki; Tomoko Hirozane-Kishikawa; Pate Skene; Yoshihide Hayashizaki; Piero Carninci; Erich D. Jarvis

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Oct. 2006, Peer-reviewed

  
• A spliceosomal intron binding protein, IBP160, links position-dependent assembly of intron-encoded box C/D snoRNP to pre-mRNA splicing

  Tetsuro Hirose; Takashi Ideue; Misato Nagai; Masatoshi Hagiwara; Mei-Di Shu; Joan A. Steitz

  MOLECULAR CELL, Sep. 2006, Peer-reviewed

  
• Utilization of host SR protein kinases and RNA-splicing machinery during viral replication

  Takeshi Fukuhara; Takamitsu Hosoya; Saki Shimizu; Kengo Sumi; Takako Oshiro; Yoshiyuki Yoshinaka; Masaaki Suzuki; Naoki Yamamoto; Leonore A. Herzenberg; Leonard A. Herzenberg; Masatoshi Hagiwara

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Jul. 2006, Peer-reviewed

  
• Bio-Object, a stochastic simulator for post-transcriptional regulation

  N Ohki; M Hagiwara

  BIOINFORMATICS, May 2005, Peer-reviewed

  
• Differential expression of glutamate receptors in avian neural pathways for learned vocalization

  K Wada; H Sakaguchi; ED Jarvis; M Hagiwara

  JOURNAL OF COMPARATIVE NEUROLOGY, Aug. 2004, Peer-reviewed

  
• Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts

  M Takano; Y Koyama; H Ito; S Hoshino; H Onogi; M Hagiwara; K Furukawa; T Horigome

  JOURNAL OF BIOLOGICAL CHEMISTRY, Mar. 2004, Peer-reviewed

  
• TNF alpha-induced ATF3 expression is bidirectionally regulated by the JNK and ERK pathways in vascular endothelial cells

  K Inoue; T Zama; T Kamimoto; R Aoki; Y Ikeda; H Kimura; M Hagiwara

  GENES TO CELLS, Jan. 2004, Peer-reviewed

  
• Involvement of MKK6 in TCRa beta(int)CD69(lo): a target population for apoptotic cell death in thymocytes

  H Suzuki; JH Wu; K Hossain; T Ohhata; J Du; AA Akhand; A Hayakawa; H Kimura; M Hagiwara; Nakashima, I

  FASEB JOURNAL, Jun. 2003, Peer-reviewed

  
• Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear protein CROP/]Luc7A

  H Umehara; Y Nishii; M Morishima; Y Kakehi; N Kioka; T Amachi; J Koizumi; M Hagiwara; K Ueda

  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Feb. 2003, Peer-reviewed

  
• Identification of ATF-2 as a transcriptional regulator for the tyrosine hydroxylase gene

  T Suzuki; T Yamakuni; M Hagiwara; H Ichinose

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 2002, Peer-reviewed

  
• Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy.

  Wada K; Inoue K; Hagiwara M

  Biochimica et biophysica acta, Aug. 2002, Peer-reviewed

  
• A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway

  T Zama; R Aoki; T Kamimoto; K Inoue; Y Ikeda; M Hagiwara

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2002, Peer-reviewed

  
• Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway

  T Zama; R Aoki; T Kamimoto; K Inoue; Y Ikeda; M Hagiwara

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2002, Peer-reviewed

  

Misc.

• INTEGRATED EPIGENETIC ANALYSIS OF WILLIAMS SYNDROME

  Ryo Kimura; Roy Lardenoije; Kiyotaka Tomiwa; Yasuko Funabiki; Masatoshi Nakata; Shiho Suzuki; Tomonari Awaya; Takeo Kato; Shin Okazaki; Toshiya Murai; Toshio Heike; Bart Rutten; Masatoshi Hagiwara

  EUROPEAN NEUROPSYCHOPHARMACOLOGY, Oct. 2019

  
• 外科医が行う臓器保存の研究とその副次的効果

  金光 瑛彰; 趙 向東; 祝迫 恵子; 八木 真太郎; 萩原 正敏

  日本外科学会定期学術集会抄録集, Apr. 2021

  
• Redox-Dependent Protein Quality Control in the Endoplasmic Reticulum: Folding to Degradation

  Masatoshi Hagiwara; Kazuhiro Nagata

  ANTIOXIDANTS & REDOX SIGNALING, May 2012

  
• Phosphorylation-dependent regulation of pre-mRNA splicing

  Masatoshi Hagiwara

  Protein, nucleic acid and enzyme, Dec. 2009

  
• Drug screening by visualization of RNA splicing

  野島 孝之; 萩原 正敏

  Cell technology, 2010

  
• 非オピオイド鎮痛薬の創製

  豊本雅靖; 豊本雅靖; 栗原崇; 中川貴之; 井上飛鳥; 木村亮; 喜井勲; 喜井勲; 澤田照夫; 澤田照夫; 荻原孝史; 荻原孝史; 永安一樹; 岸貴之; 小野木博; 小野木博; 田口純平; 吉田優; 青木淳賢; 青木淳賢; 細谷孝充; 萩原正敏

  鎮痛薬・オピオイドペプチドシンポジウムプログラム・抄録集, 2021

  
• 変異ジストロフィン遺伝子に対するエクソンスキップ誘導活性を有する化合物の探索

  二宮賢介; 佐古有季哉; 喜井勲; 細谷孝充; 萩原正敏

  日本RNA学会年会要旨集, 2015

  
• 異種アジド選択的逐次クリック反応:機能性分子集積への展開

  菅野貴美幸; 吉田優; 喜井勲; 松下武司; 萩原正敏; 細谷孝充

  日本化学会講演予稿集, 2013

  
• DYRK1A and cognition: A lifelong relationship.

  Arbones ML; Thomazeau A; Nakano-Kobayashi A; Hagiwara M; Delabar JM

  Pharmacology & therapeutics, Sep. 2018, Peer-reviewed

  
• Modulation of Alternative Splicing with Chemical Compounds in New Therapeutics for Human Diseases

  Kenji Ohe; Masatoshi Hagiwara

  ACS CHEMICAL BIOLOGY, Apr. 2015, Peer-reviewed

  
• 抗C型肝炎ウイルス能をもつ低分子化合物の同定

  奥野友紀子; NGUYEN Bao Ngoc; NGUYEN Bao Ngoc; 飯田慶; 出縄政嗣; 坂本直哉; 影近弘之; 萩原正敏

  日本ウイルス学会学術集会プログラム・抄録集, 2013

  
• 筋ジストロフィーに対するトランスレーショナル・リサーチ I.エクソン・スキップ ジストロフィンpre-mRNAのスプライシングを変化させる低分子化合物の探索

  萩原正敏; 松尾雅文; 片岡直行; 飯田慶; 西田篤史

  筋ジストロフィーに対するトランスレーショナル・リサーチ 平成22-24年度 総括研究報告書, 2013

  
• 筋ジストロフィーに対するトランスクリプトーム創薬の試み

  飯田慶; 飯田慶; 片岡直行; 西田篤史; 川口修治; 豊田哲郎; 古野正朗; 松尾雅文; 林崎良英; 萩原正敏

  日本RNA学会年会要旨集, 2013

  
• 家族性自律神経失調症におけるIKBKAP遺伝子の異常スプライシング機構の解析

  片岡直行; 吉田真弓; 薄井知美; 佐久間真希; 萩原正敏

  日本RNA学会年会要旨集, 2013

  
• Challenges to congenital genetic disorders with "RNA-targeting" chemical compounds

  Yasushi Ogawa; Masatoshi Hagiwara

  PHARMACOLOGY & THERAPEUTICS, Jun. 2012, Peer-reviewed

  
• 抗HCV活性を有するN-(morpholine-4-carbonyloxy)amidine化合物の同定

  北詰晶子; 坂本直哉; 奥野友紀子; 中川美奈; 中川美奈; 柿沼晴; 柿沼晴; 幾世橋佳; 新田沙由梨; 村川美也子; 東正新; 櫻井幸; 萩原正敏; 渡辺守

  肝臓, 2012

  
• パーキンソン病におけるPINK1/Parkin及びミトコンドリア機能調節低分子化合物の網羅的解析

  張長亮; 奥野友紀子; 萩原正敏; 高橋良輔

  パーキンソン病・運動障害疾患コングレスプログラム・抄録集, 2012

  
• PUF60は筋分化特異的な選択的スプライシングの調節因子であり,筋発生に必要である

  片岡直行; 野島孝之; 大城(井手上)杜子; 武内章英; 喜井勲; 萩原正敏

  日本RNA学会年会要旨集, 2012

  
• 家族性自律神経失調症原因遺伝子IKBKAPの異常スプライシング機構の解析

  片岡直行; 吉田真弓; 薄井知美; 佐久間真紀; 萩原正敏

  日本分子生物学会年会プログラム・要旨集(Web), 2012

  
• 蛍光蛋白発現HCV培養系を用いたHigh-content screening assayの樹立及びHCVエントリー阻害剤探索への応用

  北詰晶子; 坂本直哉; 坂本直哉; 奥野友紀子; 筬島裕子; 中川美奈; 中川美奈; 柿沼晴; 柿沼晴; 植山真由美; 小野塚泉; 船岡祐介; 渡辺貴子; 幾世橋佳; 新田沙由梨; 村川美也子; 萩原正敏; 渡辺守

  肝臓, 2011

  
• Cell based high-throughput screeningによる新規抗ウイルス小分子の同定及びその作用機構の解析

  北詰晶子; 坂本直哉; 坂本直哉; 奥野友紀子; 筬島裕子; 中川美奈; 中川美奈; 柿沼晴; 柿沼晴; 植山真由美; 小野塚泉; 船岡祐介; 渡辺貴子; 幾世橋佳; 新田沙由梨; 村川美也子; 萩原正敏; 渡辺守

  肝臓, 2011

  
• EYFP発現HCV培養系を用いたHigh-content screening assayによるウイルス侵入阻害剤の同定

  北詰晶子; 坂本直哉; 坂本直哉; 奥野友紀子; 中川美奈; 中川美奈; 柿沼晴; 柿沼晴; 山本満千; 幾世橋佳; 新田沙由梨; 村川美也子; 萩原正敏; 渡辺守

  肝臓, 2011

  
• スプライシングの一時停止/再開による遺伝子発現制御機構の解析

  二宮賢介; 二宮賢介; 二宮賢介; 片岡直行; 萩原正敏; 萩原正敏

  日本RNA学会年会要旨集, 2010

  
• ケミカルスクリーニング推進に向けた基盤構築

  湯浅(石上)磨里; 奥野友紀子; 渡辺由紀子; 萩原正敏

  日本薬理学会関東部会プログラム・要旨集, 2009

  
• 単純ヘルペスウイルスタンパク質ICP27の標的RNAの網羅的解析と認識配列同定の試み

  川村豪伸; 野島孝之; 野島孝之; 片岡直行; 井手上社子; 萩原正敏; 萩原正敏

  日本ウイルス学会学術集会プログラム・抄録集, 2009

  
• ウイルスタンパク質のPML選択的スプライシング制御

  野島孝之; 野島孝之; 井手上社子; 仲野谷宗図; 川村豪伸; 森本智美; 川口寧; 片岡直行; 萩原正敏; 萩原正敏

  日本RNA学会年会要旨集, 2009

  
• 選択的スプライシング調節因子SRp75の標的遺伝子の同定と解析

  片岡直行; 片岡直行; 二宮賢介; 吉田真由美; 吉田真由美; 萩原正敏

  日本RNA学会年会要旨集, 2009

  
• SRタンパク質リン酸化酵素Clkの特異的阻害剤TG003を用いたSRp75のリン酸化と選択的スプライシングの制御

  片岡直行; 四方田純一郎; 四方田純一郎; 村木倫子; 村木倫子; 木村宏; 萩原正敏

  日本薬理学会関東部会プログラム・要旨集, 2009

  
• [Overview of chemical biology].

  Hagiwara M

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica, Jul. 2008, Peer-reviewed

  
• [Development of protein kinase inhibitors and their applications for chemical biology].

  Hagiwara M

  Nihon yakurigaku zasshi. Folia pharmacologica Japonica, Jul. 2008, Peer-reviewed

  
• ウイルス感染が引き起こすPMLアイソフォームの切り換え

  野島孝之; 野島孝之; 井手上(大城)社子; 仲野谷宗図; 川村豪伸; 片岡直行; 萩原正敏; 萩原正敏

  日本RNA学会年会要旨集, 2008

  
• [Kinase inhibitors].

  Hagiwara M; Usuki H

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Oct. 2007, Peer-reviewed

  
• Cross-talks between transcription and post-transcriptional events within a 'mRNA factory'

  Masatoshi Hagiwara; Takayuki Nojima

  JOURNAL OF BIOCHEMISTRY, Jul. 2007, Peer-reviewed

  
• 遺伝子発現を制御するnon-coding RNA (特集 細胞分化を制御する遺伝情報デコードシステム--転写因子・クロマチン制御・non-coding RNA)

  野島 孝之; 萩原 正敏

  細胞工学, Jan. 2006

  
• Alternative splicing: a new drug target of the post-genome era.

  Hagiwara M

  Biochimica et biophysica acta, Dec. 2005, Peer-reviewed

  
• Manipulation of alternative splicing by a newly developed inhibitor of Clks

  M Muraki; B Ohkawara; T Hosoya; H Onogi; J Koizumi; T Koizumi; K Sumi; Y Jun-ichiro; MV Murray; H Kimura; K Furuichi; H Shibuya; AR Krainer; M Suzuki; M Hagiwara

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jun. 2004

  
• SRタンパク質リン酸化酵素ClkによるSRp75のリン酸化と選択的スプライシングの制御

  四方田純一郎; 村木倫子; 萩原正敏; 木村宏

  日本分子生物学会年会プログラム・講演要旨集, 2004

  
• Novel SR-rich-related protein clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk

  R Katsu; H Onogi; K Wada; Y Kawaguchi; M Hagiwara

  JOURNAL OF BIOLOGICAL CHEMISTRY, Nov. 2002

  
• A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans

  Y Kimura; EE Corcoran; K Eto; K Gengyo-Ando; M Muramatsu; R Kobayashi; JH Freedman; S Mitani; M Hagiwara; AR Means; H Tokumitsu

  EMBO REPORTS, Oct. 2002

  
• A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans

  Y Kimura; EE Corcoran; K Eto; K Gengyo-Ando; M Muramatsu; R Kobayashi; JH Freedman; S Mitani; M Hagiwara; AR Means; H Tokumitsu

  EMBO REPORTS, Oct. 2002

  
• Spectrum of autoantibodies against a dynamin-related protein, dymple

  Y Muro; T Kamimoto; Y Tomita; M Hagiwara

  ARTHRITIS AND RHEUMATISM, Jul. 2000

  
• A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo.

  NAGAI Y; MIYAZAKI M; AOKI R; ZAMA T; INOUYE S; HIROSE K; IINO M; HAGIWARA M

  Nat. Biotechnol, 2000

  
• Direct imaging of phosphorylation-dependent conformational change and DNA binding of CREB by electron microscopy

  Jiro Usukura; Yuji Nishizawa; Atsushi Shimomura; Kazuto Kobayashi; Toshiharu Nagatsu; Masatoshi Hagiwara

  Genes to Cells, 2000

  
• Novel RING finger proteins, Air1p and 2p interact with Hmt1p and inhibit the arginine methylation of Np13p.

  J.Biol. Chem., 2000

  
• SPK-1 a C. elegans SR proteins kinase homologue, is essential for embryogenesis and required for germline development.

  Mech. Dev., 2000

  
• A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo.

  Nat. Biotechnol, 2000

  
• Song-induced phosphorylation of cAMP response element-binding protein in the songbird brain

  H Sakaguchi; K Wada; M Maekawa; T Watsuji; M Hagiwara

  JOURNAL OF NEUROSCIENCE, May 1999

  
• The subcellular localization of SF2/ASF is regulated by the direct interaction with SR protein kinases (SRPKs)

  KOIZUMI J; OKAMOTO Y; ONOGI H; MAYEDA A; KRAINER A R; HAGIWARA M

  J. Biol. Chem., 1999

  
• The subcellular localization of SF2/ASF is regulated by the direct interaction with SR protein kinases (SRPKs).

  J. Biol. Chem., 1999

  
• Dominant negative ATF1 blocks cyclic AMP-induced neurite outgrowth in PC12D cells

  A Shimomura; Y Okamoto; Y Hirata; M Kobayashi; G Kawakami; K Kiuchi; T Wakabayashi; M Hagiwara

  JOURNAL OF NEUROCHEMISTRY, Mar. 1998

  
• Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles.

  Biochem. Biophys. Res. Commun., 1998

  
• Dymple, a Novel Dynamin-like High Molecular Weight GTPase Lacking a Proline-rich Carboxyl-terminal Domain in Mammalian Cells.

  J.Biol. Chem., 1998

  
• Characterization of a Serum Response Factor-Like Protein in Saccharomyces cerevisiae, Rlml, Which Has Transcriptional Activity Regulated by the Mpli(Slt2)Mitogen-Activated Protein Kinase Pathway

  Mol. Cell. Biol., 1997

  
• Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na, K-ATPase al subunit gene promotor.

  Nucleic Acid Research., 1997

  
• Characterization of a Serum Response Factor-Like Protein in Saccharomyces cerevisiae, Rlml, Which Has Transcriptional Activity Regulated by the Mpli(Slt2)Mitogen-Activated Protein Kinase Pathway.

  Mol. Cell. Biol., 1997

  
• Gene therapy against an experimental glioma using adeno-associated virus vectors

  H Okada; K Miyamura; T Itoh; M Hagiwara; T Wakabayashi; M Mizuno; P Colosi; G Kurtzman; J Yoshida

  GENE THERAPY, Nov. 1996

  
• Purification and identification of a major activator for p38 from osmotically shocked cells. Activation of MAPKK6 by osmotic shock, tumor Necrosis factor-a and H202.

  J. Biol. Chem., 1996

  
• Calmodulin-dependent protein kinase II potentiates transcriptional activation through ATF1, but not CREB.

  J. Biol. Chem., 1996

  
• A novel kinase cascade mediated by MAPKK6 and MKK3.

  J. Biol. Chem., 1996

  
• LIGHT-INDUCED CREB PHOSPHORYLATION AND GENE-EXPRESSION IN RAT RETINAL CELLS

  K YOSHIDA; J IMAKI; H MATSUDA; M HAGIWARA

  JOURNAL OF NEUROCHEMISTRY, Oct. 1995

  
• Recombinant cyclic AMP response element binding protein(CREB) phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei.

  J. Biol. Chem., 1994

  
• PHOSPHORYLATED CREB BINDS SPECIFICALLY TO THE NUCLEAR-PROTEIN CBP

  JC CHRIVIA; RPS KWOK; N LAMB; M HAGIWARA; MR MONTMINY; RH GOODMAN

  NATURE, Oct. 1993

  
• Stimulus-transcripution coupling through the cAMP responsive factor CREB is rate-limited by the nuclear entry of PK-A

  Molecular and Cellular Biology, 1993

  
• Stimulus-transcripution coupling through the cAMP responsive factor CREB is rate-limited by the nuclear entry of PK-A.

  Molecular and Cellular Biology, 1993

  
• TRANSCRIPTIONAL ATTENUATION FOLLOWING CAMP INDUCTION REQUIRES PP-1-MEDIATED DEPHOSPHORYLATION OF CREB

  M HAGIWARA; A ALBERTS; P BRINDLE; J MEINKOTH; J FERAMISCO; T DENG; M KARIN; S SHENOLIKAR; M MONTMINY

  CELL, Jul. 1992

  
• OVERCOMING OF VINBLASTINE RESISTANCE BY ISOQUINOLINESULFONAMIDE COMPOUNDS IN ADRIAMYCIN-RESISTANT LEUKEMIA-CELLS

  S WAKUSAWA; S NAKAMURA; K TAJIMA; K MIYAMOTO; M HAGIWARA; H HIDAKA

  MOLECULAR PHARMACOLOGY, Jun. 1992

  
• Identification of a 80 kDa calmodulin-binding protein as a new Ca2+/calmodulin-dependent kinase by renaturation blotting assay(RBA).

  Biochem. J., 1992

  
• Accelerated proliferation and interleukin-2 production of thymocytes by stimulation of soluble anti-CD3 monoclonal antibody in transgenic mice carrying a rabbit protein kinase C alpha.

  J. Biol. Chem., 1992

  

Awards

• 20 Jun. 2023

  ２０２３年度特別賞(日本毒性学会)

External funds: Kakenhi

• Synthetic investigation of pathological phase separation of RNA-binding proteins

  Grant-in-Aid for Scientific Research (S)

  Broad Section H

  Kyoto University

  萩原 正敏

  From 05 Jul. 2021, To 31 Mar. 2026, Granted

  病的液-液相分;SRタンパク;RNA ポリメラーゼII;転写;スプライシング;病的液-液相分離;SRタンパク質;RNA結合蚕白質;液－液相分離;RNAプロセシング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H05042/
• Therapeutic Drug Discovery and Elucidation of RNA Disease Pathogenesis by Use of CRISPR-Based Disease iPS Cells and Animal Models

  Grant-in-Aid for Scientific Research (S)

  Kyoto University

  Masatoshi Hagiwara

  From 29 May 2015, To 31 Mar. 2020, Project Closed

  遺伝性疾患;スプライシング制御;ポストゲノム創薬;遺伝子性疾患;スプライシング介入ルール;RNA病;トランスクリプトーム解析;モデルトランスクリプトーム解析;RNA病モデル;トランスクリプトーム;kibans;CRISPR;iPS;スプライシング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H05721/
• トランスクリプトームの人為的操作による遺伝病の治療

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  萩原 正敏

  From 01 Apr. 2015, To 31 Mar. 2016, Discontinued

  創薬;CRISPR;iPS;スプライシング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H02505/
• Strategy for controlling intractable pain by targeting casein kinase 1 signaling system

  Grant-in-Aid for Scientific Research (C)

  Kagoshima University

  Takashi Kurihara

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  神経障害性疼痛;炎症性疼痛;脊髄;リン酸化酵素;vacuolar-ATPase;Wntシグナル;難治性疼痛;カゼインキナーゼ 1;ケミカルバイオロジー;霊長類疼痛モデル;カゼインキナーゼ1

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460723/
• Identification of a small molecule that induces autophagy-mediated degradation of TAU

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Masatoshi HAGIWARA

  From 01 Apr. 2012, To 31 Mar. 2015, Project Closed

  タウオパチー;アルツハイマー病;化合物;スクリーニング;タウ;リン酸化酵素;急性ストレス;神経変性疾患;アルツハイマー;FTDP-17;ストレス;細胞;DYRK1A;低分子化合物;ハイスループット

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24241076/
• Analysis of abnormal splicing mechanism and application for thetreatment of Muscular Dystrophy

  Grant-in-Aid for Scientific Research (C)

  Kyoto University;Tokyo Medical and Dental University

  Naoyuki KATAOKA

  From 01 Apr. 2010, To 31 Mar. 2013, Project Closed

  スプライシング;ジストロフィン;筋ジストロフィー;低分子化合物;レポーター

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22603002/
• Analyzing neuronal development through deciphering splicing code

  Grant-in-Aid for Scientific Research (A)

  Kyoto University;Tokyo Medical and Dental University

  Masatoshi HAGIWARA

  From 01 Apr. 2009, To 31 Mar. 2012, Project Closed

  スプライシング;大脳皮質形成;エクソンアレイ;スプライシング調節因子;プロファイリング解析;神経発生;mRNA;大脳皮質;発現パターン

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21249013/
• Decipher the mechanism to generate proteome diversity with area specificity in mammalian central nervous system

  Grant-in-Aid for Scientific Research (C)

  Tokyo Medical and Dental University

  Akihide TAKEUCHI

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  (1)選択的スプライシング制御;(2)相互排他的スプライシング制御;(3)組織特異的スプライシング制御;(4)スプライシング・レポーター;(5)スプライシング・レポーターマウス;(6)Fibroblast Growth Factor Receptor2;(7)RNA結合タンパク質;(8)スプライス・サイト認識;選択的スプライシング制御;相互排他的スプライシング制御;組織特異的スプライシング制御;スプライシング・レポーター;スプライシング・レポーターマウス;Fibroblast Growth Factor Receptor2;RNA結合タンパク質;スプライス・サイト認識;神経科学;発生、分化;スプライシング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19500269/
• Molecular Mechanism of Inronless mRNA transport

  Grant-in-Aid for Scientific Research (B)

  Tokyo Medical and Dental University

  Masatoshi HAGIWARA

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  CBC;REF;mRNA;核外油症;SRPK;mRNA核外輸送;UAP56;キャップ構造;ICP27;イントロンレスmRNA;EJC;核外輸送

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390071/
• ヘルペスウイルスRNAの核外輸送制御機構の解明

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tokyo Medical and Dental University

  萩原 正敏

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  単純ヘルペスウイルス;PML;ICP27;選択的スプライシング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19041027/
• ケミカルジェネティクスによる生体機能の解明

  Grant-in-Aid for Scientific Research (C)

  Tokyo Medical and Dental University

  萩原 正敏

  From 01 Apr. 2006, To 31 Mar. 2007, Project Closed

  ケミカルバイオロジー;ケミカルジェネティクス;疾患ケミカルバイオロジー;リン酸化酵素阻害剤;バイオイメージングプローブ;PETプローブ;アフィニティ磁性ナノビーズ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18631008/
• 生体における組織特異的選択的スプライシング制御機構の解明

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tokyo Medical and Dental University

  黒柳 秀人

  From 01 Apr. 2005, To 31 Mar. 2006, Project Closed

  選択的スプライシング;線虫;GFP;組織特異性;変異体;レポーター;RNA結合タンパク質;RNAプロセッシング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17017016/
• Manipulation of aberrant splicing.

  Grant-in-Aid for Scientific Research (B)

  Tokyo Medical and Dental University

  Masatoshi HAGIWARA

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  選択的スプライシング;mRNA;Clk;CLASP;ウイルス;SRPK;SRPIN340;抗ウイルス薬;インシュリン;Clk1;4;TG003;SR蛋白質;Sty;蛋白リン酸化酵素阻害剤, alternative splicing;mRNA;Clk;CLASP;virus

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390074/
• 新規リン酸化酵素阻害剤によるスプライシング制御とエイズウイルスの複製阻害

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tokyo Medical and Dental University

  福原 武志

  From 01 Apr. 2004, To 31 Mar. 2006, Project Closed

  スプライシング;キナーゼ;キナーゼ阻害剤;SRPK;HIV;SARS;CMV;ウイルス;SR

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16017234/
• Phosphoiylation -dependent regulation of alternative splicing

  Grant-in-Aid for Scientific Research (B)

  Tokyo Medical and Dental University

  Masatoshi HAGIWARA

  From 01 Apr. 2002, To 31 Mar. 2004, Project Closed

  選択的スプライシング;リン酸化;SR蛋白質;SRPK;ClK;mRNAプロセシング;プロテインキナーゼ阻害剤;Clk;特異的阻害剤, alternative splicing;Phosphorylation;SR proteins;SRPK;Clk;mRNA processing;protein kinase inhibitor

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14380326/
• Phosphorylation-dependent regulation of splicing and transport of mRNA

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tokyo University of Agriculture and Technology;Tokyo Medical and Dental University

  Masatoshi HAGIWARA

  From 01 Apr. 2002, To 31 Mar. 2007, Project Closed

  選択的スプライシング;核外輸送;スプライシングコード;Aly;REF;温度感受性変異株;SF1-U2AF;asd-1;転写;スプライシング共役系;SRPIN340;SRPK;エキソンスキッピング;cellular codes;インシュリン;構成的スプライシング;SF1-U2AF複合体;RNA結合蛋白質;SRタンパク質;Clk1;Sty;蛋白リン酸化酵素阻害剤;U2AF;RSドメイン;Clk;mRNAプロセシング;特異的阻害剤;mRNA輸送;RS蛋白;リン酸化酵素, Alternative splicing;mRNA export;Aly;REF;SF1-U2AF;CBP20;EJC

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14035102/
• Biobjeによる遺伝子発現シミュレーションの線虫個体への応用

  Grant-in-Aid for Scientific Research on Priority Areas

  Biological Sciences

  Tokyo Medical and Dental University

  木村 芳滋

  From 01 Apr. 2002, To 31 Mar. 2003, Project Closed

  シミュレーション工学;生体生命情報学;バーチャルリアリティ;発現制御

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-14015210/
• 生物新機能と創薬をめざす生体内分子科学

  Grant-in-Aid for Creative Scientific Research

  Gifu University

  鈴木 正昭

  From 01 Apr. 2001, To 31 Mar. 2006, Project Closed

  PET;高速メチル化;蛍光プローブ;人工核酸;キナーゼ;阻害剤;神経因性疼痛;シグナル解析;3成分連結PG合成法;non-RI光親和性標識法;ABCトランスポーター;Socius;神経性疼痛;プラナーポジトロンイメージング;MicroPET;光親和性標識法;レチノイド;キナーゼ阻害剤;34mCl;プロスグランジン;RXRアンタゴニスト;可視化プローブ;4'-チオリボヌクレオシド;ダントロレン誘導体;Cu-ATSM;サリドマイド;リピドA;15R-TIC;リアノジン受容体;PGE_2;アロディニア;DNAチップ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13NP0401/
• Biobjeによる遺伝子発現制御機構のシミュレーション

  Grant-in-Aid for Scientific Research on Priority Areas (C)

  Biological Sciences

  Tokyo Medical and Dental University

  萩原 正敏

  From 01 Apr. 2001, To 31 Mar. 2002, Project Closed

  シミュレーション工学;生体生命情報学;バーチャルリアリティ;発現制御

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13208005/
• 歌学習臨界期におけるキンカチョウ脳内CREBの活性化と遺伝子発現変動

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Biological Sciences

  Tokyo Medical and Dental University

  萩原 正敏

  From 01 Apr. 2001, To 31 Mar. 2002, Project Closed

  遺伝子;言語学習;行動学;神経科学;発現制御

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13041018/
• 遺伝子発現過程のOIMによるシミュレーション

  Grant-in-Aid for Scientific Research on Priority Areas (C)

  Biological Sciences

  Tokyo Medical and Dental University

  萩原 正敏

  From 01 Apr. 2000, To 31 Mar. 2001, Project Closed

  シミュレーション;遺伝情報プログラム;Biobje

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12208018/
• キンカチョウの歌学習機構における転写因子CREBの役割

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Biological Sciences

  Tokyo Medical and Dental University

  萩原 正敏

  From 01 Apr. 2000, To 31 Mar. 2001, Project Closed

  CREB;キンカチョウ;歌学習;グルタミン酸受容体

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12053223/
• スプライシング因子リン酸化酵素の活性制御機構

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Tokyo Medical and Dental University

  萩原 正敏

  From 01 Apr. 2000, To 31 Mar. 2001, Project Closed

  RNA結合蛋白;SF2;SRPK;線虫

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12029208/
• アポトーシスの細胞内リアルタイムイメージング

  Grant-in-Aid for Exploratory Research

  Tokyo Medical and Dental University

  萩原 正敏

  From 01 Apr. 1999, To 31 Mar. 2000, Project Closed

  apoptosis;caspase;PARP

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11877020/
• 選択的スプライシングのリン酸化制御機構

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Tokyo Medical and Dental University

  萩原 正敏

  From 01 Apr. 1999, To 31 Mar. 2000, Project Closed

  SRPK;SF2;ASF;splicing

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-11155208/
• GFP蛍光による細胞内リン酸化反応のイメージング

  Grant-in-Aid for Exploratory Research

  Tokyo Medical and Dental University

  萩原 正敏

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  CAMP;GFP;CREB;KID

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10877019/
• New methods for expression cloning of alternative splicing factors

  Grant-in-Aid for Scientific Research (B)

  TOKYO MEDICAL & DENTAL UNIVERSITY

  Masatoshi HAGIWARA

  From 01 Apr. 1998, To 31 Mar. 2000, Project Closed

  選択的スプライシング;GFP;RNAi;SRPK;アルギニンメチル;SR蛋白リン酸化;カルシトニン;alternative splicing;RT-PCR;SF2;ASF;リン酸化反応;スプライシング, alternative splicing;GFP;arginine methylation;RNAi;SRPK;phosphorylation of SR proteins

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10558102/
• mRNA factoryのリン酸化制御

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Tokyo Medical and Dental University

  萩原 正敏

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  mRNAファクトリー;SF2;ASF;SRPK;speckled patterm

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10174210/
• 転写因子ATF1による細胞増殖制御とその融合遺伝子による癌化機構の解明

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Tokyo Medical and Dental University

  萩原 正敏

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  ATF1;CREB;E1A;ドミナントネガティブ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10152217/
• 細胞内情報伝達の生理機能解析と情報分子の可視化

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  The University of Tokyo

  飯野 正光

  From 01 Apr. 1998, To 31 Mar. 1999, Project Closed

  カルシウム;イノシトール三燐酸;膵臓β細胞;分泌;受精;蛍光カルシウム指示薬;cAMP;GFP;血管平滑筋;転写制御

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09273101/
• New vector system for the gene therapy of abdominal cancers.

  Grant-in-Aid for Scientific Research (B)

  Nagoya University

  Yuji NIMURA

  From 01 Apr. 1997, To 31 Mar. 1999, Project Closed

  遺伝子治療;発現ベクター;腹膜播腫癌;遺伝子発現制御;腹膜播種癌;レトロウイルスベクター;ドキシサイクリン;on;off制御;GFP, gene therapy;retroviral vector;peritoneal dessemination;transcriptional regulation

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09557103/
• Molecular mechanisms of functional expression of transcription regulation factors through their interaction with coactivators or corepressors

  Grant-in-Aid for Scientific Research on Priority Areas (A)

  Tohoku University

  Yoshiaki FUJII-KURIYAMA

  From 01 Apr. 1997, To 31 Mar. 2001, Project Closed

  転写因子;転写共役因子;転写因子間相互作用;作用機構;転写開始;転写伸長反応;再構成;転写活性化;転写開始複合体;リン酸化;スプライシング;DNA結合能;相互作用;TFIIH;TFIIE;TFIID;コアクチベーター;DSIF;Ah受容体;STAT3;CREB;基本転写装置;コアクチベータ-;TF II D;TF II E;TF II H;転写調節因子;ノックアウトマウス, transcription factor;transcriptional cofactor;inter-transcriptional interaction;functional mechanism;transcription initiation;transfer extension reaction;reorganization;transfer activation

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09277102/
• Prospero相同遺伝子はCREBによって制御され神経可塑性に関与するのか?

  Grant-in-Aid for Scientific Research on Priority Areas

  Tokyo Medical and Dental University

  萩原 正敏

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  長期記憶;シナプス可塑性;CREB;prox1

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09259216/
• 悪性黒色腫に発現する融合症遺伝子EWS/ATF1の癌化機構における役割の解明

  Grant-in-Aid for Scientific Research on Priority Areas

  Tokyo Medical and Dental University

  萩原 正敏

  From 01 Apr. 1997, To 31 Mar. 1998, Project Closed

  CREB;ATF1;増殖関連遺伝子;CRE;E1A

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09254225/
• CREB/ATF1ドミナント・ネガティブ分子の構築と遺伝子改変マウスの作成

  Grant-in-Aid for Exploratory Research

  Nagoya University

  萩原 正敏

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  神経発生;ドミナントネガティブ;RL-ATF1;CREB;PC12細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08877025/
• Identification of novel protein kinases from Beghet patientsser

  Grant-in-Aid for Scientific Research (B)

  Tokyo Medical and Dental University;Nagoya University

  Masatoshi HAGIWARA

  From 01 Apr. 1996, To 31 Mar. 1998, Project Closed

  自己抗原;抗体スクリーニング;MKK6;SPOP;ZF5;Dymple;Ki67;Mitosin;自己抗体;核内蛋白;Behcet病;TAK1;P38;HOG, auto antigen;immunoscreening;MKK6;SPOP;ZF5;Dymple

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457046/
• CREB欠損ショウジョウバエを用いる記憶関連遺伝子のサブトラクションクローニング

  Grant-in-Aid for Scientific Research on Priority Areas

  Nagoya University

  萩原 正敏

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  CREB;ターゲット遺伝子;E-カドヘリン;dual-specific phosphatase;長期記憶

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08270219/
• リン酸化による転写調節因子構造変化のイメージング

  Grant-in-Aid for Scientific Research on Priority Areas

  Nagoya University

  臼倉 治郎

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  低角度回転蒸着;DNA;転写因子;RNAポリメラーゼ;電子顕微鏡;大腸菌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08260209/
• CREB結合蛋白CBPのリン酸化による制御

  Grant-in-Aid for Scientific Research on Priority Areas

  Nagoya University

  萩原 正敏

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  Bridging Factors;MAPKK6;リン酸化制御

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08250206/
• IMAGING OF PHOTOTRANSDUCTION PROCESS IN RENTINAL CELLS

  Grant-in-Aid for international Scientific Research

  Nagoya University

  Jiro USUKURA

  From 01 Apr. 1996, To 31 Mar. 1997, Project Closed

  光情報伝達系;低角度回転蒸着;視細胞;イメージング;cGMP;PDE;光受容;構造解析, Phototransduction;Low angle rotary shadowing;Photoreceptor cell;Imaging;cGMP;PDE;Photoreception;Structural analysis

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08044267/
• Analysis of signal transduction in human glioma cells transfected with cytokine gene

  Grant-in-Aid for Scientific Research (B)

  Nagoya University

  Jun YOSHIDA

  From 01 Apr. 1995, To 31 Mar. 1998, Project Closed

  脳腫瘍;インターフェロン;腫瘍壊死因子;遺伝子;リポソーム;NF-kB;リン酸化蛋白;シグナル伝達;NF-κB, BRAIN TUMOR;INTERFERON;TNF;GENE;LIPOSOME;NF-kappaB;PHOSPHORYLATION;SIGNAL TRANSDUCTION

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457312/
• 蛋白リン酸化酵素の核内輸送機構と新しい核膜孔複合体の探求

  Grant-in-Aid for Scientific Research on Priority Areas

  Nagoya University

  萩原 正敏

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  カルモジュリン;CaMキナーゼ;核内局在

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07282208/
• 長期記憶に関与する転写調節因子CREBのターゲット遺伝子のクローニング

  Grant-in-Aid for Scientific Research on Priority Areas

  Nagoya University

  萩原 正敏

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  長期記憶;CREB;ターゲット遺伝子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07278217/
• 接着分子CD44の脳腫瘍における過剰発現機構とその生物学的意義

  Grant-in-Aid for Scientific Research on Priority Areas

  Nagoya University

  萩原 正敏

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  接着分子;CD44;アンチセンス;グリオーマ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07273229/
• リン酸化による転写調節因子構造変化のイメージング

  Grant-in-Aid for Scientific Research on Priority Areas

  Nagoya University

  臼倉 治郎

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  DNA;CREB;転写調節;低角度回転蒸着;原子間力顕微鏡

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07268208/
• CREB結合蛋白CBPの多様性とそのリン酸化制御機構 -ATF/CREBファミリーの特異性はCBPによって説明可能か-

  Grant-in-Aid for Scientific Research on Priority Areas

  Nagoya University

  萩原 正敏

  From 01 Apr. 1995, To 31 Mar. 1996, Project Closed

  CREB;CBP;AFT1;ドミナントネガティブ

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07258208/
• 受容体から核へcAMPシグナルを伝達するAキナーゼの細胞内ソーティング

  Grant-in-Aid for General Scientific Research (C)

  Nagoya University

  萩原 正敏

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  cAMP;Aキナーゼ;CREB

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06670104/
• Molecular basis and generation of new compounds for probing phosphorylation-mediated signaling pathways

  Grant-in-Aid for Scientific Research (A)

  Nagoya University

  Hiroyoshi HIDAKA

  From 01 Apr. 1994, To 31 Mar. 1997, Project Closed

  細胞内シグナリング;蛋白質リン酸化酵素;阻害剤;構造活性相関;蛋白質立体構造;創薬;コンピューターシュミレーション;特異的阻害剤;分子設計;有機合成;活性調節部位;分子基礎理論, Intracellular signal transduction;Protein kinase;Inhibitor;Tertiary structure;Structure-activity relationship;Drug design;Computer simulation

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06507001/
• リン酸化による転写調節因子構造変化のイメージング

  Grant-in-Aid for Scientific Research on Priority Areas

  Nagoya University

  臼倉 治郎

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  転写調節因子;燐酸化;イメージング;CREB;CRP;Holiday Junction;低角度回転蒸着法;原子間力顕微鏡

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06276209/
• 転写調節因子CREBの細胞内ソーティングとそのリン酸化制御

  Grant-in-Aid for Scientific Research on Priority Areas

  Nagoya University

  萩原 正敏

  From 01 Apr. 1994, To 31 Mar. 1995, Project Closed

  CREB;細胞周期依存的リン酸化反応;cdc2 kinase

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06266205/
• Cloning of CBP and its regulation mechanism

  Grant-in-Aid for international Scientific Research

  Tokyo Medical and Dental University;Nagoya University

  Masatoshi HAGIWARA

  From 01 Apr. 1994, To 31 Mar. 1997, Project Closed

  CREB;CBP;ATF1;リン酸化;phosphorylation;転写調節;蛋白リン酸化;CREB結合蛋白, CREB;CBP;ATF1;Phosphorylation

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06044106/
• 受容体から核内の転写因子CREBに至るcAMPシグナルトランスダクションの研究

  Grant-in-Aid for Encouragement of Young Scientists (A)

  Nagoya University

  萩原 正敏

  From 01 Apr. 1993, To 31 Mar. 1994, Project Closed

  cAMP;Aキナーゼ;CREB

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05780528/
• リン酸化依存性転写調節因子と転写基本因子との間に介存する制御因子の探求

  Grant-in-Aid for Scientific Research on Priority Areas

  Nagoya University

  萩原 正敏

  From 01 Apr. 1993, To 31 Mar. 1994, Project Closed

  CBP;CREB;アダプター因子

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05273209/
• ヒト甲状腺細胞の癌化・増殖過程に関与するβ型Cキナ-ゼの薬理学的解析

  Grant-in-Aid for General Scientific Research (C)

  Nagoya University

  萩原 正敏

  From 01 Apr. 1991, To 31 Mar. 1992, Project Closed

  カルシウム情報伝達系;Ca^<2+>;CaM依存性蛋白質キナ-ゼ;副甲状腺

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670099/
• Functional Modification of Calcium Dependent Proteins by Phosphorylation

  Grant-in-Aid for General Scientific Research (C)

  Nagoya University

  Ryoji KOBAYASHI

  From 01 Apr. 1990, To 31 Mar. 1992, Project Closed

  新しいカルシウム情報伝達系;アネキシン;EFーハンド蛋白質;カルシウム受容蛋白質;カルシウムシグナルネットワ-ク;カルシウムシグナル;EFーハンドタンパク質;カルシウム結合タンパク質, Calcium Signaling;Annexin;EF-hand protein;Calcium binding protein;Calcium signal network

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02680156/
• The Development of the Strategy for the Presumption of the Tertiary Structure of Protein Kinases by Specific Inhibitors

  Grant-in-Aid for Developmental Scientific Research (B)

  Nagoya University

  Hiroyoshi HIDAKA

  From 01 Apr. 1990, To 31 Mar. 1993, Project Closed

  プロテインキナーゼ;プロテインキナーゼ阻害剤;阻害剤データベース;プロテインキナ-ゼ;プロテインキナ-ゼ阻害剤;阻害剤デ-タベ-ス, Protein kinase;Protein Kinase Inhibitor;Inhibitor Data Base

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02557009/
• Cキナ-ゼサブタイプの定量化、及び細胞の癌化に果たす役割の解析

  Grant-in-Aid for Scientific Research on Priority Areas

  Nagoya University

  日高 弘義

  From 01 Apr. 1989, To 31 Mar. 1990, Project Closed

  Cキナ-ゼアイソザイム;エンザイムイムノアッセイ;細胞増殖

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01614512/
• The role of Ca^<2+>-dependent protein kinases in central nervous system in health and diseases.

  Grant-in-Aid for General Scientific Research (A)

  Nagoya University

  Hiroyoshi HIDAKA

  From 01 Apr. 1989, To 31 Mar. 1992, Project Closed

  蛋白質リン酸化反応;カルシウム依存性蛋白質リン酸化酵素;カルモデュリンキナ-ゼII;Cーキナ-ゼ;酵素抗体法;KNー62;Hー89;蛋白質リン酸化酵素阻害剤;Aーキナ-ゼ;δ型Cキナ-ゼ;ζ型Cキナ-ゼ;長期増強現象;GABA放出;ACAMPー81;MARCKS;Cキナ-ゼアイソザイム;エンザイムイムノアッセイ;Cキナ-ゼアイソザイムの細胞特異的発現;特異的阻害剤, Protein phosphorylation;Ca^<2+>-dependent protein kinase;CaM-kinase II;Protein kinase C;EIA;KN-62;H-89;Protein kinase inhibitor

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01440027/
• Unification and reconstruction of myosin phosphorylation theory on contractile response of smooth muscle and nonmuscle cells.

  Grant-in-Aid for international Scientific Research

  Nagoya University

  Hiroyoshi HIDAKA

  From 01 Apr. 1989, To 31 Mar. 1992, Project Closed

  ミオシン軽鎖リン酸化反応;蛋白質リン酸化反応;Ca^<2+>結合蛋白質;プロテインキナ-ゼ;KNー62;ミオシン脱リン酸化酵素;カルモデュリンキナ-ゼII;カルシウム結合蛋白;カルギザリン;カルバスクリン, Myosin light chain phosphorylation;Protein phosphorylation;Ca^<2+> binding protein (s);Protein Kinase;KN-62

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01044066/
• Development of analytical method of molecular function in protein kinases by using newly synthesized protein kinase inhibitor - affinity chromatography

  Grant-in-Aid for Developmental Scientific Research

  Nagoya University School of Medicine;Mie University

  Hiroyoshi HIDAKA

  From 01 Apr. 1987, To 31 Mar. 1989, Project Closed

  プロテインキナーゼ阻害剤;アフィニティークロマトグラフ;ミオシン軽鎖キナーゼ;Cキナーゼ;Aキナーゼ;ML-9;サイロキシン, Myosin light chain kinase;ML-9;Thyroxine;Affinity chromatography;Protein kinase C

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-62880018/
• A Comprehensive Amino Acid Transporter-Based Therapeutic Strategy for Lethal Prostate Cancer

  Grant-in-Aid for Scientific Research (B)

  Basic Section 56030:Urology-related

  Chiba University

  坂本 信一

  From 01 Apr. 2024, To 31 Mar. 2027, Granted

  アミノ酸トランスポーター;致死性前立腺癌;エクソソーム;去勢抵抗性前立腺癌;神経内分泌前立腺癌

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24K02575/

External funds: others

• 産学連携により臨床試験を目指すワンストップ創薬支援 (2024年度分)

  文部科学省, 医療研究開発推進事業費補助金

  From 01 Apr. 2024, To 31 Mar. 2025

  代表
• 産学連携により臨床試験を目指すワンストップ創薬支援 (2023年度分)

  文部科学省, 医療研究開発推進事業費補助金

  From 01 Apr. 2023, To 31 Mar. 2024

  代表
• 産学連携により臨床試験を目指すワンストップ創薬支援 (2022年度分)

  文部科学省, 医療研究開発推進事業費補助金

  From 01 Apr. 2022, To 31 Mar. 2023

  代表
• アジアオンライン創薬ネットワークに関する事業 (2021年度分)

  厚生労働省, 医療研究開発推進事業費補助金(令和2年度繰越分)

  From 01 Apr. 2021, To 31 Mar. 2022

  代表
• 臨床研究につなぐワンストップ創薬支援 (2021年度分)

  文部科学省, 医療研究開発推進事業費補助金

  From 01 Apr. 2021, To 31 Mar. 2022

  代表
• 「大型創薬研究基盤を活用した創薬オープンイノベーションの推進」（細胞アッセイから治験までのワンストップ創薬支援）

  文部科学省 創薬等ライフサイエンス研究支援基盤事業

  From 2012, To 2016

  萩原　正敏
• 「大型創薬研究基盤を活用した創薬オープンイノベーションの推進」（細胞アッセイから治験までのワンストップ創薬支援） （平成26年度分）

  文部科学省 創薬等ライフサイエンス研究支援基盤事業

  From 01 Apr. 2014, To 31 Mar. 2015

  萩原　正敏
• 「大型創薬研究基盤を活用した創薬オープンイノベーションの推進」（細胞アッセイから治験までのワンストップ創薬支援） （平成27年度分）

  文部科学省 医療研究開発推進事業費補助金

  From 01 Apr. 2015, To 31 Mar. 2016

  萩原　正敏
• 医薬品分野（アルツハイマー病、非臨床評価、薬剤疫学） （平成27年度分）

  厚生労働省 医薬品等審査迅速化事業費補助金

  From 01 Apr. 2015, To 31 Mar. 2016

  萩原　正敏
• 「大型創薬研究基盤を活用した創薬オープンイノベーションの推進」（細胞アッセイから治験までのワンストップ創薬支援） （平成28年度分）

  医療研究開発推進事業費補助金

  From 01 Apr. 2016, To 31 Mar. 2017

  萩原　正敏
• 医薬品分野（アルツハイマー病、非臨床評価、薬剤疫学） （平成28年度分）

  医薬品等審査迅速化事業費補助金

  From 01 Apr. 2016, To 31 Mar. 2017

  萩原　正敏　
• 臨床研究につなぐワンストップ創薬支援 （平成29年度分）

  医療研究開発推進事業費補助金

  From 01 Apr. 2017, To 31 Mar. 2018

  萩原 正敏
• 臨床研究につなぐワンストップ創薬支援 （平成30年度分）

  医療研究開発推進事業費補助金

  From 01 Apr. 2018, To 31 Mar. 2019

  萩原 正敏
• 臨床研究につなぐワンストップ創薬支援 （2019年度分）

  医療研究開発推進事業費補助金

  From 01 Apr. 2019, To 31 Mar. 2020

  萩原　正敏
• アジアオンライン創薬ネットワークに関する事業 （2020年度分）

  医療研究開発推進事業費補助金

  From 01 Apr. 2020, To 31 Mar. 2021

  萩原　正敏
• 臨床研究につなぐワンストップ創薬支援 （2020年度分）

  医療研究開発推進事業費補助金

  From 01 Apr. 2020, To 31 Mar. 2021

  萩原　正敏
• 肝炎ウイルス感染複製増殖過程の解明と新規治療法開発に関する研究

  平成２２年度、 厚生労働科学研究費補助金　肝炎等克服緊急対策研究事業

  分担
• 「未熟児網膜症の原因と治療に関する調査研究」

  平成21年度、厚労科研費補助金　難治性疾患克服研究事業　

  代表

Education

Teaching subject(s)

• From 01 Apr. 2023, To 31 Mar. 2024

  Practicum on Medical Research

  E065, Year-long, Graduate School of Medicine, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Human Gross Anatomy and its Laboratory Course

  B001, Spring, Faculty of Medicine, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Human Gross Anatomy and its Laboratory Course

  L030, Spring, Faculty of Medicine, 0
• From 01 Apr. 2022, To 31 Mar. 2023

  Human Gross Anatomy and its Laboratory Course

  B001, Spring, Faculty of Medicine, 6
• From 01 Apr. 2022, To 31 Mar. 2023

  Practicum on Medical Research

  E065, Year-long, Graduate School of Medicine, 2
• From Apr. 2011, To Mar. 2012

  医科学研究

  Spring, 医学研究科
• From Apr. 2013, To Mar. 2014

  Human Gross Anatomy and its Laboratory Course

  Spring, 医学部
• From Apr. 2013, To Mar. 2014

  Introduction to medical science

  Year-long, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Hands-on medical research experience

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Human Gross Anatomy and its Laboratory Course

  Spring, 医学部
• From Apr. 2014, To Mar. 2015

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2014, To Mar. 2015

  Human Anatomy

  Spring, 医学研究科
• From Apr. 2014, To Mar. 2015

  Human Anatomy

  Spring, 工学研究科
• From Apr. 2014, To Mar. 2015

  Human Anatomy

  Spring, 総合生存学館
• From Apr. 2014, To Mar. 2015

  Introduction to medical science

  Year-long, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Hands-on medical research experience

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Human Gross Anatomy and its Laboratory Course

  Spring, 医学部
• From Apr. 2015, To Mar. 2016

  Human Anatomy

  Spring, 総合生存学館
• From Apr. 2015, To Mar. 2016

  Human Anatomy

  Spring, 工学研究科
• From Apr. 2015, To Mar. 2016

  Human Anatomy

  Spring, 医学研究科
• From Apr. 2015, To Mar. 2016

  Introduction to medical science

  Year-long, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2016, To Mar. 2017

  Human Gross Anatomy and its Laboratory Course

  Spring, 医学部
• From Apr. 2016, To Mar. 2017

  Human Anatomy

  Spring, 総合生存学館
• From Apr. 2016, To Mar. 2017

  Human Anatomy

  Spring, 工学研究科
• From Apr. 2016, To Mar. 2017

  Human Anatomy

  Spring, 医学研究科
• From Apr. 2016, To Mar. 2017

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2017, To Mar. 2018

  Human Gross Anatomy and its Laboratory Course

  Spring, 医学部
• From Apr. 2017, To Mar. 2018

  Human Gross Anatomy and its Laboratory Course

  Spring, 医学部
• From Apr. 2017, To Mar. 2018

  Human Anatomy

  Spring, 工学研究科
• From Apr. 2017, To Mar. 2018

  Human Anatomy (LIMS)

  Spring, 医学研究科
• From Apr. 2017, To Mar. 2018

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2018, To Mar. 2019

  Human Gross Anatomy and its Laboratory Course

  Spring, 医学部
• From Apr. 2018, To Mar. 2019

  Human Gross Anatomy and its Laboratory Course

  Spring, 医学部
• From Apr. 2018, To Mar. 2019

  Human Anatomy

  Spring, 工学研究科
• From Apr. 2018, To Mar. 2019

  Human Anatomy (LIMS)

  Spring, 医学研究科
• From Apr. 2018, To Mar. 2019

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2019, To Mar. 2020

  Human Gross Anatomy and its Laboratory Course

  Spring, 医学部
• From Apr. 2019, To Mar. 2020

  Human Gross Anatomy and its Laboratory Course

  Spring, 医学部
• From Apr. 2019, To Mar. 2020

  Human Anatomy (LIMS)

  Spring, 医学研究科
• From Apr. 2019, To Mar. 2020

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2020, To Mar. 2021

  Human Gross Anatomy and its Laboratory Course

  Spring, 医学部
• From Apr. 2020, To Mar. 2021

  Human Gross Anatomy and its Laboratory Course

  Spring, 医学部
• From Apr. 2020, To Mar. 2021

  Human Anatomy (LIMS)

  Spring, 医学研究科
• From Apr. 2020, To Mar. 2021

  Practicum on Medical Research

  Year-long, 医学研究科
• From Apr. 2021, To Mar. 2022

  Human Gross Anatomy and its Laboratory Course

  Spring, 医学部
• From Apr. 2021, To Mar. 2022

  Human Gross Anatomy and its Laboratory Course

  Spring, 医学部
• From Apr. 2021, To Mar. 2022

  Practicum on Medical Research

  Year-long, 医学研究科

Participation in PhD Defense

• Physiological concentrations of glucocorticoids induce pathological DNA double-strand breaks

  Salma Akter, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Trapping of CDC42 C-terminal variants in the Golgi drives pyrin inflammasome hyperactivation

  ISA MASAHIKO, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia

  TANAKA ATSUSHI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• An ancient retroviral RNA element hidden in mammalian genomes and its involvement in co-opted retroviral gene regulation

  KITAO KOICHI, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Magnetic Control of Cells by Chemical Fabrication of Melanin

  NISHIO KOSUKE, Graduate School of Medicine, Sub-chief Examiner

  23 Mar. 2023
• Enhancement of Regnase-1 expression with stem loop-targeting antisense oligonucleotides alleviates inflammatory diseases

  Tse Ka Man Carman, Graduate School of Medicine, Chief Examiner

  26 Sep. 2022
• Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe

  JUNG YEJIN, Graduate School of Medicine, Sub-chief Examiner

  23 May 2022
• Mechanisms of thrombin-Induced myometrial contractions: Potential targets of progesterone

  NISHIMURA FUMITOMO, Graduate School of Medicine, Chief Examiner

  24 Nov. 2022
• Orthogonal Protein-Responsive mRNA Switches for Mammalian Synthetic Biology

  ONO HIROKI, Graduate School of Medicine, Chief Examiner

  23 Mar. 2022
• Thioredoxin interacting protein (Txnip) forms redox sensitive high molecular weight nucleoprotein complexes

  CRISTIANE LUMI HIRATA, Graduate School of Medicine, Sub-chief Examiner

  24 May 2021
• Paradoxical activation of c-Src as a drug-resistant mechanism

  HIGUCHI MAKIO, Graduate School of Medicine, Chief Examiner

  26 Jul. 2021
• Impact of Gba2 on neuronopathic Gaucher’s disease and α-synuclein accumulation in medaka (Oryzias latipes)

  NAKANISHI　ETSURO, Graduate School of Medicine, Sub-chief Examiner

  24 Jan. 2022
• Local application of Usag-1 siRNA can promote tooth regeneration in Runx2-deficient mice

  MISHIMA SAYAKA, Graduate School of Medicine, Chief Examiner

  24 Jan. 2022

Administration

School management (title, position)

• From 01 Oct. 2022, To 31 Mar. 2024

  国際戦略本部運営協議会 On-site Laboratory専門部会 部会員
• From 31 Jan. 2023, To 31 Mar. 2024

  総合解剖センター センター長
• From 31 Jan. 2023, To 31 Mar. 2024

  先天異常標本解析センター センター長
• From 01 Nov. 2022, To 29 Nov. 2022

  国際卓越研究大学構想検討委員会　研究等体制強化計画検討タスクフォース　コアファシリティ検討小委員会 委員長
• From 11 Oct. 2022, To 12 Sep. 2023

  国際卓越研究大学構想検討委員会　研究等体制強化計画検討タスクフォース 委員
• From 01 Oct. 2022, To 31 Mar. 2024

  戦略調整会議 委員
• From 01 Apr. 2022, To 31 Mar. 2023

  産官学連携本部運営会議 委員
• From 01 Feb. 2022, To 30 Jun. 2022

  戦略調整会議事業・財務戦略検討委員会 委員
• From 01 Apr. 2022, To 30 Sep. 2022

  国際戦略本部運営協議会 On-site Laboratory専門部会 部会員
• From 01 Apr. 2012, To 31 Mar. 2014

  設備整備ワーキンググループ委員会
• From 01 Apr. 2012, To 30 Sep. 2014

  設備整備ワーキンググループ 委員
• From 31 Jan. 2013, To 30 Jan. 2017

  先天異常標本解析センター長
• From 31 Jan. 2013, To 30 Jan. 2017

  総合解剖センター長
• From 01 Oct. 2014, To 30 Sep. 2016

  設備整備ワーキンググループ 座長
• From 01 Oct. 2014, To 30 Sep. 2016

  財務委員会 委員
• From 14 Jan. 2016, To 30 Sep. 2016

  総合技術部委員会 委員
• From 01 Apr. 2016, To 31 Mar. 2018

  医・薬学域長
• From 01 Apr. 2016, To 31 Mar. 2018

  基礎・社会医学系長
• From 01 Apr. 2016, To 30 Sep. 2016

  評価に応じた予算配分に係る制度検討ワーキンググループ 委員
• From 12 Jul. 2016

  指定国立大学法人制度検討ワーキンググループ委員
• From 30 Sep. 2016, To 31 Mar. 2017

  指定国立大学法人制度検討タスクフォース 委員
• From 14 Jan. 2016, To 30 Sep. 2018

  総合技術部委員会 委員
• From 01 Apr. 2016, To 31 Mar. 2018

  運営協議員
• From 01 Apr. 2016, To 31 Mar. 2020

  医・薬学域長
• From 01 Apr. 2016, To 31 Mar. 2020

  基礎・社会医学系長
• From 01 Nov. 2017, To 30 Sep. 2018

  理事補
• From 01 Oct. 2013

  京都大学(南部)総合研究棟(医薬系)施設整備事業提案審査委員会の設置に伴う委員
• From 01 Nov. 2017, To 30 Sep. 2020

  理事補
• From 24 Jul. 2018, To 30 Sep. 2020

  企画委員会On-site Laboratory認定専門委員会 副委員長
• From 01 Oct. 2018, To 30 Sep. 2020

  戦略調整会議 委員
• From 01 Oct. 2018, To 30 Sep. 2020

  戦略調整会議On-site Laboratory小委員会 委員長
• From 05 Jun. 2018, To 30 Sep. 2020

  戦略調整会議留学生リクルーティングオフィス小委員会 委員
• From 22 Oct. 2018, To 30 Sep. 2020

  戦略調整会議授業料設定の柔軟化検討小委員会 委員長
• From 01 Jan. 2019, To 31 Dec. 2019

  国際教育委員会国際学生交流委員会アムジェン・スカラーズ・プログラム小委員会 委員
• From 01 Oct. 2018, To 31 Mar. 2021

  教育研究評議会 評議員
• From 01 Apr. 2018, To 31 Mar. 2020

  高等研究院運営協議員委員
• From 01 Apr. 2019, To 31 Mar. 2020

  産官学連携本部運営会議
• From 01 Jan. 2020, To 31 Dec. 2020

  国際教育委員会国際学生交流委員会アムジェン・スカラーズ・プログラム小委員会 委員
• From 01 Oct. 2020, To 30 Sep. 2022

  企画委員会On-site Laboratory認定専門委員会 副委員長
• From 01 Oct. 2020, To 30 Sep. 2022

  戦略調整会議 委員
• From 01 Oct. 2020, To 31 Mar. 2021

  戦略調整会議授業料設定の柔軟化検討小委員会 委員長
• From 01 Oct. 2020, To 31 Mar. 2022

  戦略調整会議若手研究者リクルーティング促進策小委員会 委員
• From 01 Oct. 2020, To 31 Mar. 2021

  戦略調整会議教員の事務負担の軽減策（事務効率化）小委員会 委員長
• From 01 Jun. 2021, To 31 Mar. 2022

  戦略調整会議研究支援体制の再構築（技術職員）小委員会 委員
• From 01 Oct. 2020, To 30 Sep. 2022

  理事補
• From 01 Jan. 2019, To 31 Dec. 2021

  国際教育委員会国際学生交流委員会アムジェン・スカラーズ・プログラム小委員会 委員
• From 01 Oct. 2020, To 30 Sep. 2022

  全学共用スペース有効活用専門委員会 委員
• From 01 Apr. 2021, To 31 Mar. 2023

  教育研究評議会 評議員

Faculty management (title, position)

• From 01 Feb. 2024, To 31 Mar. 2024

  生命科学研究科附属生命情報解析教育センター運営委員会_委員
• From 01 Aug. 2023, To 31 Mar. 2024

  脳機能総合研究センター運営委員会_委員
• From 01 Oct. 2022, To 31 Mar. 2024

  管理体制委員会委員
• From 01 Oct. 2022, To 31 Mar. 2024

  京都大学医薬系総合研究棟管理運営委員会委員
• From 01 Apr. 2023, To 31 Mar. 2025

  医学・生命科学研究支援機構（iSAL）運営委員会委員
• 解剖・先天異常標本解析センター委員会、委員
• 学位審査選定委員会、委員
• From 27 Jan. 2011

  利益相反予備審査委員会
• From 01 Oct. 2013, To 30 Sep. 2018

  副研究科長
• From 01 Oct. 2017, To 30 Sep. 2018

  医学広報委員会
• 医学研究科・医学部人権委員会
• From 01 Oct. 2013, To 31 Mar. 2021

  医学研究科・医学部将来計画検討委員会
• To 31 Mar. 2014

  医学研究科運営委員会
• From 10 May 2012, To 31 Mar. 2016

  医学部学務委員会
• From 01 Oct. 2013, To 30 Sep. 2018

  医科学専攻長
• From 01 Apr. 2013, To 31 Mar. 2015

  寄附講座運営委員会（免疫ゲノム医学）
• From 26 Jan. 2012

  バイオ・フロンティア・プラットフォーム運営委員会
• From 01 Apr. 2013

  附属ゲノム医学センター運営委員会
• 医学研究支援センター運営委員会
• From 01 Apr. 2016, To 31 Mar. 2020

  寄附講座運営委員会（免疫ゲノム医学）
• From 01 Apr. 2016, To 31 Mar. 2020

  寄附講座運営委員会（創薬医学）
• From 01 Oct. 2017, To 30 Sep. 2020

  管理体制委員会
• From 01 Aug. 2017, To 31 Jul. 2019

  脳機能総合研究センター運営委員会
• 医学部資料館運営委員会
• From 24 Sep. 2015

  教員人事活性化委員会
• From 01 Apr. 2015

  「医学領域」産学連携推進機構会議
• From 01 Oct. 2016, To 30 Sep. 2020

  京都大学医薬系総合研究棟管理運営委員会　委員
• From 01 Dec. 2016, To 30 Nov. 2018

  京都大学分子生物実験研究棟管理運営委員会　委員
• 医学研究科・医学部財務委員会
• From 01 Apr. 2019, To 31 Mar. 2021

  評議員(附属病院)
• From 01 Apr. 2019, To 31 Mar. 2021

  将来計画検討委員会
• From 01 Oct. 2020, To 30 Sep. 2022

  管理体制委員会委員
• From 01 Oct. 2020, To 30 Sep. 2022

  医薬系総合研究棟管理委員会委員
• From 01 Apr. 2021, To 31 Mar. 2022

  将来計画検討委員会
• From 11 Jun. 2020, To 31 Mar. 2022

  柳井基金運営委員会委員