Basic Information

Affiliated programs (koza)

• Graduate School of Biostudies, 高次生命科学専攻 細胞増殖統御学, 教授

Faculty

• 理学部

Academic Degree

• 修士（理学）(京都大学)
• 博士（理学）(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院理学研究科博士後期課程生物科学専攻, 修了
• 京都大学, 大学院理学研究科修士課程生物科学専攻, 修了

Academic Resume (Undergraduate School/Majors)

• 京都大学, 農学部水産学科, 卒業

Research History

• From Oct. 2024, To Present

  Institute of Science Tokyo, Medical Research Laboratory, Institute of Integrated Research, Professor
• From Apr. 2023, To Sep. 2024

  Tokyo Medical and Dental University, Medical Research Institute, 教授
• From Apr. 2022, To Present

  Kyoto University, Institute for Life and Medical Sciences, Professor
• From Oct. 2016, To Mar. 2022

  京都大学ウイルス・再生医科学研究所, 教授
• From Mar. 2008, To Sep. 2016

  Kyoto University, Institute for Virus Research, 教授
• From Oct. 2005, To Mar. 2009

  Japan Science and Technology Agency, さきがけ研究者
• From Mar. 2004, To Jan. 2006

  京都大学生命科学研究科, 助手
• From Apr. 1999, To Feb. 2004

  Kyoto University, Graduate School of Biostudies, 日本学術振興会特別研究員

Language of Instruction

• Japanese

ID,URL

• ORCID ID

  0000-0002-3698-0034

• J-Global ID

  200901017427099448

• External link

  https://www.homeo-med.s.isct.ac.jp/index_en.html

Website(s) (URL(s))

• https://www2.infront.kyoto-u.ac.jp/Toyoshima-HP/

researchmap URL

• https://researchmap.jp/read0122107

Research

Research Topics, Overview of the research

• Research Topics

  Organ remodeling in homeostasis, repair, and regeneration.
  

• Overview of the research

  Each organ in the adult body responses to tissue damage or physiological changes of the body through regulating the multicelullar network by which organ size and functions are determined. Our laboratory studies the mechanisms of tissue remodeling especially focusing on a regenerating organ from acute and chronic damage, as well as maternal remodeling organ during pregnancy. How the tissue mechanics and secretory molecules affect the transcriptional network in the multicellular systems is one topic in the projects. These endogenous tissue remodeling mechanisms would be applied for regenerative medicine. We also interested in how the maternal tissue remodeling contributes to fetal growth or developmental origin of health and disease (DOHaD).

Research Areas

• Life sciences, Developmental biology, 再生医療
• Life sciences, Developmental biology, 母体ー胎児連関
• Life sciences, Medical biochemistry, 生化学
• Life sciences, Dermatology
• Life sciences, Cell biology, 幹細胞

Papers

• The transcription factor RORα is required for the development of type 1 innate lymphoid cells in adult bone marrow

  Shinya Abe; Moe Kagao; Takuma Asahi; Ryoma Kato; Shizue Tani-ichi; Akihiro Shimba; Riki Ishibashi; Hitoshi Miyachi; Satsuki Kitano; Masaki Miyazaki; Hans-Reimer Rodewald; Fumiko Toyoshima; Koichi Ikuta

  The Journal of Immunology, 13 Mar. 2025

  
• Receptor-independent regulation of Gα13 by alpha-1-antitrypsin C-terminal peptides

  Yonghak Park; Shigeyuki Matsumoto; Kosuke Ogata; Biao Ma; Ryo Kanada; Yuta Isaka; Norihito Arichi; Xiaowen Liang; Ritsuko Maki; Tohru Kozasa; Yasushi Okuno; Hiroaki Ohno; Yasushi Ishihama; Fumiko Toyoshima

  Journal of Biological Chemistry, Feb. 2025

  
• Gene targeting in adult organs using in vivo cleavable donor plasmids for CRISPR-Cas9 and CRISPR-Cas12a

  Riki Ishibashi; Ritsuko Maki; Fumiko Toyoshima

  Scientific Reports, 31 Mar. 2024, Peer-reviewed

  
• Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G2 checkpoint

  F. Toyoshima

  The EMBO Journal, 15 May 1998, Peer-reviewed

  
• A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses

  T. Moriguchi

  The EMBO Journal, 01 Dec. 1997, Peer-reviewed

  
• Periportal hepatocyte proliferation at midgestation governs maternal glucose homeostasis in mice

  Satoshi Kozuki; Mio Kabata; Satoko Sakurai; Keiko Iwaisako; Tomomi Nishimura; Masakazu Toi; Takuya Yamamoto; Fumiko Toyoshima

  Communications Biology, 04 Dec. 2023, Peer-reviewed

  
• Development of an in vivo cleavable donor plasmid for targeted transgene integration by CRISPR-Cas9 and CRISPR-Cas12a

  Riki Ishibashi; Ritsuko Maki; Satsuki Kitano; Hitoshi Miyachi; Fumiko Toyoshima

  Scientific Reports, 22 Oct. 2022, Peer-reviewed

  
• Vasculature atrophy causes a stiffened microenvironment that augments epidermal stem cell differentiation in aged skin

  Ryo Ichijo; Koichiro Maki; Mio Kabata; Teruasa Murata; Arata Nagasaka; Seiichiro Ishihara; Hisashi Haga; Tetsuya Honda; Taiji Adachi; Takuya Yamamoto; Fumiko Toyoshima

  Nature Aging, 11 Jul. 2022, Peer-reviewed

  
• Delineation of biliary epithelial cell dynamics in maternal liver during pregnancy

  Satoshi Kozuki; Satoko Sakurai; Atsushi Suzuki; Takuya Yamamoto; Fumiko Toyoshima

  Genes to Cells, 10 Jan. 2022, Peer-reviewed

  
• Discovery of anti-inflammatory physiological peptides that promote tissue repair by reinforcing epithelial barrier formation

  Yukako Oda; Chisato Takahashi; Shota Harada; Shun Nakamura; Daxiao Sun; Kazumi Kiso; Yuko Urata; Hitoshi Miyachi; Yoshinori Fujiyoshi; Alf Honigmann; Seiichi Uchida; Yasushi Ishihama; Fumiko Toyoshima

  Science Advances, 19 Nov. 2021, Peer-reviewed

  Access this paper :

  
• Vasculature-driven stem cell population coordinates tissue scaling in dynamic organs

  Ryo Ichijo; Mio Kabata; Hiroyasu Kidoya; Fumitaka Muramatsu; Riki Ishibashi; Kota Abe; Ko Tsutsui; Hirokazu Kubo; Yui Iizuka; Satsuki Kitano; Hitoshi Miyachi; Yoshiaki Kubota; Hironobu Fujiwara; Aiko Sada; Takuya Yamamoto; Fumiko Toyoshima

  Science Advances, Feb. 2021, Peer-reviewed

  Access this paper :

  
• Genome editing with the donor plasmid equipped with synthetic crRNA-target sequence

  Riki Ishibashi; Kota Abe; Nanami Ido; Satsuki Kitano; Hitoshi Miyachi; Fumiko Toyoshima

  Scientific Reports, Dec. 2020, Peer-reviewed

  
• Transient elevation of cytoplasmic calcium ion concentration at a single cell level precedes morphological changes of epidermal keratinocytes during cornification

  Teruasa Murata; Tetsuya Honda; Gyohei Egawa; Yasuo Yamamoto; Ryo Ichijo; Fumiko Toyoshima; Teruki Dainichi; Kenji Kabashima

  Scientific Reports, 01 Dec. 2018, Peer-reviewed

  Access this paper :

  
• Tbx3-dependent amplifying stem cell progeny drives interfollicular epidermal expansion during pregnancy and regeneration

  Ryo Ichijo; Hiroki Kobayashi; Saori Yoneda; Yui Iizuka; Hirokazu Kubo; Shigeru Matsumura; Satsuki Kitano; Hitoshi Miyachi; Tetsuya Honda; Fumiko Toyoshima

  NATURE COMMUNICATIONS, Sep. 2017, Peer-reviewed

  Access this paper :

  
• A G-quadruplex structure at the 5' end of the H19 coding region regulates H19 transcription

  Mitsuko Fukuhara; Yue Ma; Kazuo Nagasawa; Fumiko Toyoshima

  SCIENTIFIC REPORTS, Apr. 2017, Peer-reviewed

  
• Essential roles of Tbx3 in embryonic skin development during epidermal stratification

  Ryo Ichijo; Yui Iizuka; Hirokazu Kubo; Fumiko Toyoshima

  GENES TO CELLS, Mar. 2017, Peer-reviewed

  
• Dormant Pluripotent Cells Emerge during Neural Differentiation of Embryonic Stem Cells in a FoxO3-Dependent Manner

  Megumi Ikeda; Fumiko Toyoshima

  MOLECULAR AND CELLULAR BIOLOGY, Mar. 2017, Peer-reviewed

  
• Interphase adhesion geometry is transmitted to an internal regulator for spindle orientation via caveolin-1

  Shigeru Matsumura; Tomoko Kojidani; Yuji Kamioka; Seiichi Uchida; Tokuko Haraguchi; Akatsuki Kimura; Fumiko Toyoshima

  NATURE COMMUNICATIONS, Jun. 2016, Peer-reviewed

  Access this paper :

  
• c-Rel Regulates Inscuteable Gene Expression during Mouse Embryonic Stem Cell Differentiation

  Riki Ishibashi; Satoshi Kozuki; Sachiko Kamakura; Hideki Sumimoto; Fumiko Toyoshima

  JOURNAL OF BIOLOGICAL CHEMISTRY, Feb. 2016, Peer-reviewed

  
• PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2

  Hiroshi Hanafusa; Shin Kedashiro; Motohiro Tezuka; Motoki Funatsu; Satoshi Usami; Fumiko Toyoshima; Kunihiro Matsumoto

  NATURE CELL BIOLOGY, Aug. 2015, Peer-reviewed

  
• PCTK1 Regulates Integrin-Dependent Spindle Orientation via Protein Kinase A Regulatory Subunit KAP0 and Myosin X

  Sayaka Iwano; Ayaka Satou; Shigeru Matsumura; Naoyuki Sugiyama; Yasushi Ishihama; Fumiko Toyoshima

  MOLECULAR AND CELLULAR BIOLOGY, Apr. 2015, Peer-reviewed

  
• Pregnenolone Functions in Centriole Cohesion during Mitosis

  Mayumi Hamasaki; Shigeru Matsumura; Ayaka Satou; Chisato Takahashi; Yukako Oda; Chika Higashiura; Yasushi Ishihama; Fumiko Toyoshima

  CHEMISTRY & BIOLOGY, Dec. 2014, Peer-reviewed

  
• Inhibition of endocytic vesicle fusion by Plk1-mediated phosphorylation of vimentin during mitosis

  Keisuke Ikawa; Ayaka Satou; Mitsuko Fukuhara; Shigeru Matsumura; Naoyuki Sugiyama; Hidemasa Goto; Mitsunori Fukuda; Masaki Inagaki; Yasushi Ishihama; Fumiko Toyoshima

  CELL CYCLE, Jan. 2014, Peer-reviewed

  
• ABL1 regulates spindle orientation in adherent cells and mammalian skin

  Shigeru Matsumura; Mayumi Hamasaki; Takuya Yamamoto; Miki Ebisuya; Mizuho Sato; Eisuke Nishida; Fumiko Toyoshima

  NATURE COMMUNICATIONS, Jan. 2012, Peer-reviewed

  
• ABL1 Joins the Cadre of Spindle Orientation Machinery

  Shigeru Matsumura; Fumiko Toyoshima

  CELL STRUCTURE AND FUNCTION, 2012, Peer-reviewed

  
• Mechanisms for the oriented cell division in mammalian cells

  Fumiko Toyoshima

  Seikagaku, 2012, Peer-reviewed

  
• Revolving movement of a dynamic cluster of actin filaments during mitosis

  Masaru Mitsushima; Kazuhiro Aoki; Miki Ebisuya; Shigeru Matsumura; Takuya Yamamoto; Michiyuki Matsuda; Fumiko Toyoshima; Eisuke Nishida

  JOURNAL OF CELL BIOLOGY, Nov. 2010, Peer-reviewed

  
• Dual Role of Cdc42 in Spindle Orientation Control of Adherent Cells

  Masaru Mitsushima; Fumiko Toyoshima; Eisuke Nishida

  MOLECULAR AND CELLULAR BIOLOGY, May 2009, Peer-reviewed

  
• [Inositol phospholipid regulates spindle orientation in adherent cells].

  Toyoshima F

  Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, Sep. 2008, Peer-reviewed

  
• PtdIns(3,4,5)P3 regulates spindle orientation in adherent cells

  Fumiko Toyoshima; Shigeru Matsurnura; Hiroko Morimoto; Masaru Mitsushima; Eisuke Nishida

  DEVELOPMENTAL CELL, Dec. 2007, Peer-reviewed

  
• Spindle orientation in animal cell mitosis: Roles of integrin in the control of spindle axis

  Fumiko Toyoshima; Eisuke Nishida

  JOURNAL OF CELLULAR PHYSIOLOGY, Nov. 2007, Peer-reviewed

  
• Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1

  Shigeru Matsumura; Fumiko Toyoshima; Eisuke Nishida

  JOURNAL OF BIOLOGICAL CHEMISTRY, May 2007, Peer-reviewed

  
• Integrin-mediated adhesion orients the spindle parallel to the substratum in an EB1-and myosin X-dependent manner

  Fumiko Toyoshima; Eisuke Nishida

  EMBO JOURNAL, Mar. 2007, Peer-reviewed

  
• Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate

  H Nakajima; F Toyoshima-Morimoto; E Taniguchi; E Nishida

  JOURNAL OF BIOLOGICAL CHEMISTRY, Jul. 2003, Peer-reviewed

  
• Nuclear translocation of Plk1 mediated by its bipartite nuclear localization signal

  E Taniguchi; F Toyoshima-Morimoto; E Nishida

  JOURNAL OF BIOLOGICAL CHEMISTRY, Dec. 2002, Peer-reviewed

  
• Plk1 promotes nuclear translocation of human Cdc25C during prophase

  F Toyoshima-Morimoto; E Taniguchi; E Nishida

  EMBO REPORTS, Apr. 2002, Peer-reviewed

  
• Polo-like kinase 1 phosphorylates cyclin B1 and targets it to the nucleus during prophase

  F Toyoshima-Morimoto; E Taniguchi; N Shinya; A Iwamatsu; E Nishida

  NATURE, Mar. 2001, Peer-reviewed

  
• Nuclear export of cyclin B1 and its possible role in the DNA damage-induced G(2) checkpoint

  F Toyoshima; T Moriguchi; A Wada; M Fukuda; E Nishida

  EMBO JOURNAL, May 1998, Peer-reviewed

  
• A novel SAPK/JNK kinase, MKK7, stimulated by TNF alpha and cellular stresses

  T Moriguchi; F Toyoshima; N Masuyama; H Hanafusa; Y Gotoh; E Nishida

  EMBO JOURNAL, Dec. 1997, Peer-reviewed

  
• Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases

  F Toyoshima; T Moriguchi; E Nishida

  JOURNAL OF CELL BIOLOGY, Nov. 1997, Peer-reviewed

  
• Purification and identification of a major activator for p38 from osmotically shocked cells - Activation of mitogen-activated protein kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2

  T Moriguchi; F Toyoshima; Y Gotoh; A Iwamatsu; K Irie; E Mori; N Kuroyanagi; M Hagiwara; K Matsumoto; E Nishida

  JOURNAL OF BIOLOGICAL CHEMISTRY, Oct. 1996, Peer-reviewed

  

Presentations

• 遺伝子発現と力場の空間情報から解明する生理的臓器リモデリング機構

  豊島文子

  APPW2025, 18 Mar. 2025, Invited

  
• 血管が駆動する皮膚リモデリング機構

  豊島文子

  CVMW2024心血管代謝週間, 08 Dec. 2024, Invited

  
• 組織リモデリングにおける空間トランスクリプトームと組織剛性

  豊島文子

  第42回日本骨代謝学会学術集会, 02 Jul. 2024, Invited

  
• 胎仔サイズを調整する母体肝臓リモデリング

  豊島文子

  第23回日本再生医療学会, 23 Mar. 2024, Invited

  
• Maternal Organ Remodeling and Fetal Growth

  Fumiko Toyoshima

  IRCMS symposium, 22 Nov. 2023, Invited

  
• 皮膚のリモデリングとエイジング

  豊島文子

  第44回日本基礎老化学会シンポジウム, 11 Nov. 2023, Invited

  
• 皮膚リモデリングを担う真皮剛性と多細胞ネットワーク

  豊島文子

  第96回日本生化学会大会, 01 Nov. 2023, Invited

  
• Dermal stiffness regulates epidermal stem cell function

  FumikoToyoshima

  第75回日本細胞生物学会, 28 Jun. 2023

  
• Skin Remodeling During Life Stages

  Fumiko Toyoshima

  International Symposium on Skin Stem Cell Dynamics, 14 May 2023, Invited

  
• 組織内力場からみた幹細胞老化

  豊島文子

  第22回日本再生医療学会総会, 25 Mar. 2023, Invited

  
• Dermal stiffening causes epidermal stem cell dysfunction in aged skin.

  Fumiko Toyoshima

  International Symposium on Mechanobiology for Human Health, 22 Mar. 2023, Invited

  
• 体の生理変化に伴う皮膚リモデリング機構

  豊島文子

  第52回日本創傷治癒学会, 20 Nov. 2022, Invited

  
• Stiffened microenvironment induces epidermal stem cell differentiation in aged skin.

  Fumiko Toyoshima

  27th East-Asia Symposium, 27 Oct. 2022, Invited

  
• Vasculature-dependent epidermal stem cell state organizes tissue scaling in dynamic skin.

  Fumiko Toyoshima

  The 19th Stem Cell Research Symposium, 27 May 2022, Invited

  
• Vasculature-driven stem cell states coordinates tissue scaling in dynamic skin.

  Fumiko Toyoshima

  第94回日本生化学会大会, 05 Nov. 2021

  
• Skin remodeling during physiological body shape changes.

  Fumiko Toyoshima

  Japan-Singapore Skin Webinar Series, 13 Jul. 2021, Invited

  
• Stem cell dynamics in skin homeostasis.

  Fumiko Toyoshima

  Frontline in Developmental Biology, 22 Mar. 2018, Invited

  
• 生理的な体型変化に適応するための表皮幹細胞ダイナミクス

  豊島 文子

  高遠シンポジウム, 24 Aug. 2017, Invited

  
• Orchestration of stem and progenitor cells drives abdominal skin expansion during pregnancy

  TOYOSHIMA Fumiko

  第１５回幹細胞シンポジウム, 26 May 2017, Invited

  
• 妊娠期における皮膚幹細胞の増殖・分化制御機構PartII

  豊島 文子

  第２回京都皮膚基礎研究会, 31 Mar. 2017, Invited

  
• 生理的体型変化を担う表皮幹細胞の対称・非対称分裂

  豊島 文子

  基生研研究会, 21 Nov. 2016, Invited

  
• 皮膚伸展を担う表皮幹細胞・前駆細胞の動態システム

  豊島 文子

  HiHAワークショップ, 08 Jul. 2016, Invited

  
• 妊娠期における表皮幹細胞の増殖制御機構

  豊島 文子

  第６８回日本細胞生物学会シンポジウム, 15 Jun. 2016, Invited

  
• Stem and transit-amplifying cells orchestrate abdominal skin expansion during pregnancy

  TOYOSHIMA Fumiko

  SPIRITS Swiss-Kyoto Joint symposium on Life Science, 13 Jun. 2016, Invited

  
• Oriented stem/progenitor cell division and skin expansion during pregnancy

  豊島 文子

  iCeMSリトリート, 30 May 2016, Invited

  
• 妊娠期における皮膚幹細胞の増殖・分化制御機構

  豊島 文子

  第１回京都皮膚基礎研究会, 19 Feb. 2016, Invited

  
• Molecular mechanisms for ECM-dependent oriented cell division

  TOYOSHIMA Fumiko

  第37回日本分子生物学会大会, 25 Nov. 2014, Invited

  
• 細胞分裂軸を決めるシグナル伝達ネットワーク

  豊島 文子

  発生生物学会秋季シンポジウム, 18 Nov. 2013, Invited

  
• 細胞分裂期の膜と骨格を制御する新たなリン酸化シグナル伝達

  豊島 文子

  第８６回日本生化学会大会シンポジウム, 11 Sep. 2013, Invited

  
• 細胞分裂の軸回転と生き物の形づくり

  豊島 文子

  IGREグリーン自然科学レクチャー, 26 Jul. 2013, Invited

  
• 細胞分裂軸を決めるシグナル伝達ネットワーク

  豊島 文子

  愛知県がんセンター特別招聘セミナー, 14 Mar. 2013, Invited

  
• 細胞分裂軸を決めるリン酸化ネットワーク

  豊島 文子

  第８５回 日本生化学会, 16 Dec. 2012, Invited

  
• 細胞分裂軸を決める新たな分子機構の発見と解析.

  第33回日本分子生物学会年会、第83回日本生化学会大会合同大会, 07 Dec. 2010, 日本生化学会, Invited

  
• 紡錘体軸の方位を決める細胞内コンパス

  第82回日本生化学会大会, 21 Oct. 2009, 日本生化学会, Invited

  
• 膜脂質によるスピンドル制御

  第６７回 日本癌学会学術総会, 28 Oct. 2008, 日本癌学会, Invited

  

Books and Other Publications

• 血管減少が真皮硬化を誘導し表皮幹細胞老化を促進する

  一條遼; 豊島文子

  実験医学 Vol40, No.19, p3140-3142, Dec. 2022

  
• 皮膚拡張時における増殖の高い表皮幹細胞の出現には血管が重要である

  一條遼; 豊島文子

  医学のあゆみ, May 2022

  
• 妊娠期に腹部の皮膚が広がる仕組み

  一條遼; 豊島文子

  医学のあゆみ Vol.266, No.8, pp607-608, 2018, Not refereed

  
• 細胞の非対称分裂から見る細胞社会

  松村繁; 豊島文子

  実験医学増刊 Vol.31, No.2, pp114-121, 2013, Not refereed

  
• 哺乳類における細胞分裂軸の制御機構

  豊島文子

  生化学 Vol.84, No.2, pp81-91, 2012, Not refereed

  
• 細胞分裂軸の決定機構における膜と骨格の制御

  豊島文子

  細胞周期フロンテア pp102-106, 2010, Not refereed

  
• １枚の写真館「紡錘体軸の単純な方向性」

  豊島文子

  細胞工学 第３０巻 第３号 pp227, 2010, Not refereed

  
• 細胞の分裂軸を決定するメカニズム

  豊島文子

  Medical Bio 第５巻 第４号 pp68-73, 2008, Not refereed

  
• イノシトールリン脂質による細胞分裂軸の制御機構

  豊島文子

  蛋白質 核酸 酵素 第５３巻 第１号 pp1345-1350, 2007, Not refereed

  

Awards

• 2010

  日本生化学会, 日本生化学会奨励賞
• 2011

  文部科学省, 文部科学大臣表彰若手科学者賞
• 2010

  公益社団法人　日本生化学会, 平成22年度　日本生化学会奨励賞
• 2011

  文部科学省, 平成23年度　文部科学大臣表彰若手科学者賞

External funds: others

• Gタンパク質シグナルを制御する内在性の膜透過型ペプチドを利用した抗ウイルス薬の開発

  AMED新興・再興感染症に対する革新的医薬品等開発推進研究事業

  From 20 Oct. 2021, To 31 Mar. 2022

  豊島文子
• 生理的組織リモデリング機構の解明と臓器操作技術の開発

  CREST

  From 01 Nov. 2020, To 31 Mar. 2026

  豊島文子
• The function and regulation of mechanosensors in skin metabolism

  AMED-PRIME

  From 01 Oct. 2017, To 31 Mar. 2021

  豊島文子
• 細胞分裂軸の新たな制御機構の解析と皮膚の形成・恒常性維持における役割

  最先端・次世代研究開発支援プログラム

  From 2010, To 2013

  豊島文子
• 細胞膜脂質による分裂軸方向の制御とがん化に伴う変化

  ＪＳＴ戦略的創造研究推進制度（個人研究型）　（個人研究推進事業：さきがけ研究２１‐ＰＲＥＳＴＯ）

  From 2005, To 2008

  豊島文子

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Frontiers of Biology

  N477, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Course in Chromosome Researches

  1027, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Experiments in Systemic Life Sciences

  5013, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Experiments in Systemic Life Sciences

  5013, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2024, To 31 Mar. 2025

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Course in Chromosome Researches

  1027, Spring, Graduate School of Biostudies, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Molecular Genetics II

  3726, Spring, Faculty of Science, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Experiments in Systemic Life Sciences

  5013, Spring, Graduate School of Biostudies, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Advanced Experiments in Systemic Life Sciences

  5013, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar C

  2008, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar C

  2008, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar A

  2006, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar A

  2006, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar B

  2007, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Experiments in Systemic Life Sciences

  5013, Fall, Graduate School of Biostudies, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar D

  2009, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar B

  2007, Fall, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Molecular Genetics II

  3726, Spring, Faculty of Science, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Course in Chromosome Researches

  1027, Fall, Graduate School of Biostudies, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Experimental Course and Seminar D

  2009, Spring, Graduate School of Biostudies, 5
• From 01 Apr. 2022, To 31 Mar. 2023

  Advanced Experiments in Systemic Life Sciences

  5013, Spring, Graduate School of Biostudies, 4
• From Apr. 2011, To Mar. 2012

  Perspectives on Life Science A

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2012, To Mar. 2013

  Virus and Life Science

  Fall, 全学共通科目
• From Apr. 2012, To Mar. 2013

  Perspectives on Life Science A

  Spring, 全学共通科目
• From Apr. 2012, To Mar. 2013

  The Front Line of Life Science Research I

  Spring, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2013, To Mar. 2014

  Life Science: From Basics to Applications, from Molecular Biology to Systems Biology

  Spring, 生命科学研究科
• From Apr. 2013, To Mar. 2014

  Advanced Course in Chromosome Researches

  Fall, 生命科学研究科
• From Apr. 2013, To Mar. 2014

  Study of Life Science I

  Spring, 全学共通科目
• From Apr. 2013, To Mar. 2014

  Virus and Life Science

  Fall, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2014, To Mar. 2015

  Life Science: From Basics to Applications, from Molecular Biology to Systems Biology

  Spring, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Course in Chromosome Researches

  Spring, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Experimental Course and Seminar l

  Year-long, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Experimental Course and Seminar 2

  Year-long, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Advanced Experiments in Systemic Life Sciences

  Year-long, 生命科学研究科
• From Apr. 2014, To Mar. 2015

  Study of Life Science I

  Spring, 全学共通科目
• From Apr. 2014, To Mar. 2015

  Virus and Life Science

  Fall, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Global Frontier in Life Science B

  Fall, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2015, To Mar. 2016

  Advanced Course in Chromosome Researches

  Fall, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Virus and Life Science

  Fall, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Study of Life Science I

  Spring, 全学共通科目
• From Apr. 2015, To Mar. 2016

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2015, To Mar. 2016

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Global Frontier in Life Science B

  Fall, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2016, To Mar. 2017

  Advanced Course in Chromosome Researches

  Fall, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2016, To Mar. 2017

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Global Frontier in Life Science B

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2017, To Mar. 2018

  Advanced Course in Chromosome Researches

  Spring, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Introduction to Biology and Life Science

  Spring, 全学共通科目
• From Apr. 2017, To Mar. 2018

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2017, To Mar. 2018

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Global Frontier in Life Science B

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2018, To Mar. 2019

  Advanced Course in Chromosome Researches

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar A

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar A

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar B

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar B

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar C

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar C

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar D

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar D

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2018, To Mar. 2019

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Global Frontier in Life Science B

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2019, To Mar. 2020

  Advanced Course in Chromosome Researches

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar A

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar A

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar B

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar B

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar C

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar C

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar D

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar D

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2019, To Mar. 2020

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2020, To Mar. 2021

  Advanced Course in Chromosome Researches

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2020, To Mar. 2021

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Molecular Genetics II

  Spring, 理学部
• From Apr. 2021, To Mar. 2022

  Advanced Course in Chromosome Researches

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Introduction to Biology and Life Science

  Spring, 全学共通科目
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Experimental Course and Seminar

  Fall, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Experiments in Systemic Life Sciences

  Spring, 生命科学研究科
• From Apr. 2021, To Mar. 2022

  Advanced Experiments in Systemic Life Sciences

  Fall, 生命科学研究科

Participation in PhD Defense

• 核小体内の力学環境におけるDNAアンツイスティング機構の解明

  FUKUTE JUMPEI, Graduate School of Biostudies, Sub-chief Examiner

  25 Mar. 2024
• マウス胚尿生殖洞上皮を用いた初期前立腺発生におけるFGF10、WNT、レチノイン酸シグナルの機能解析

  UNO WATARU, Graduate School of Biostudies, Sub-chief Examiner

  25 Sep. 2023
• アレルギー性気道炎症におけるアンドロゲンによる２型ヘルパーT細胞抑制機構の解析

  EJIMA AKI, Graduate School of Biostudies, Chief Examiner

  23 Mar. 2023
• Intracellular dsRNA induces apoptotic cell death via the synergistic activation of PKR and TLR3

  ZUO WENJIE, Graduate School of Biostudies, Sub-chief Examiner

  26 Sep. 2022
• 頑健な組織形態形成を支える分子基盤の遺伝学的解析

  WADA YAYOI, Graduate School of Biostudies, Sub-chief Examiner

  23 Mar. 2022
• 神経幹細胞活性化と細胞分化におけるbHLH型転写因子Ascl１の発現動態と機能の解析

  SUEDA RISA, Graduate School of Biostudies, Sub-chief Examiner

  24 Sep. 2021
• PC3 prostate cancer cells require VCP relocalization to adapt to starvation stress, via regulation of mitochondrial activity.

  OGOR PROMISE, Graduate School of Biostudies, Sub-chief Examiner

  24 Sep. 2021
• 妊娠における母体肝臓リモデリング機構の解析

  KOZUKI SATOSHI, Graduate School of Biostudies, Chief Examiner

  23 Mar. 2022

Administration

School management (title, position)

• From 01 Dec. 2020

  京都大学研究倫理・安全推進委員会
• From 01 Oct. 2016, To 30 Sep. 2018

  附属図書館協議会 協議員
• From 01 Apr. 2017, To 31 Mar. 2018

  教育制度委員会 委員
• From 01 Oct. 2016, To 30 Sep. 2018

  附属図書館運営委員会　委員
• From 01 Oct. 2016, To 30 Sep. 2020

  図書館協議会 協議員
• From 01 Apr. 2019, To 31 Mar. 2020

  図書館協議会オープンアクセス特別委員会 委員
• From 01 Apr. 2020, To 31 Mar. 2021

  図書館協議会オープンアクセス特別委員会 委員

Faculty management (title, position)

• From 01 Apr. 2023, To 31 Mar. 2024

  男女共同参画推進委員会　委員
• From 01 Apr. 2022, To 31 Mar. 2024

  ウイルス・幹細胞システム医生物学共同研究拠点専門委員会　委員
• From 01 Apr. 2022, To 31 Mar. 2024

  ウイルス・幹細胞システム医生物学共同研究拠点運営委員会　委員
• From 01 Jul. 2021

  感染症モデル研究センター運営委員会 　委員長
• From 01 Apr. 2016

  共同利用機器等委員会　委員
• From 01 Oct. 2016

  兼業・利益相反審査委員会　委員
• From 01 Apr. 2021

  医の倫理委員会　委員
• From 01 Apr. 2022, To 31 Mar. 2024

  生命科学研究科　国際教育委員会
• From 01 Apr. 2011, To 31 Mar. 2015

  広報委員会　委員
• From 01 Apr. 2010, To 31 Mar. 2012

  兼業審査委員会　委員
• From 01 Apr. 2011, To 31 Mar. 2013

  自己点検・評価委員会　委員
• From 01 Apr. 2011, To 31 Mar. 2013

  人権委員会　委員
• From 01 Apr. 2009, To 31 Mar. 2015

  教育委員会　委員
• From 27 Sep. 1993

  コンピュータ・ネットワーク委員会　委員
• 国際教育委員会
• From 01 Apr. 2014, To 31 Mar. 2015

  職員等配置検討委員会　委員
• From 01 Apr. 2014, To 31 Mar. 2018

  兼業審査委員会　委員
• From 01 Apr. 2013, To 31 Mar. 2015

  人権委員会　委員
• From 01 Apr. 2014, To 31 Mar. 2018

  動物実験委員会　委員
• From 01 Apr. 2014

  情報セキュリティ委員会　委員
• From 01 Apr. 2013, To 31 Mar. 2015

  自己点検・評価委員会　委員
• From 01 Apr. 2016, To 31 Mar. 2018

  予算委員会　委員　
• From 01 Apr. 2016, To 31 Mar. 2018

  安全衛生委員会　委員
• From 01 Oct. 2016

  ウイルス動物実験専門委員会　委員長
• From 01 Apr. 2024

  化学物質管理委員会　委員
• From 01 Oct. 2016, To Mar. 2018

  （旧ウイルス研）予算委員会　委員長
• From 01 Oct. 2016, To Mar. 2018

  （旧ウイルス研）共同利用機器等委員会　委員
• From 01 Apr. 2017, To 31 Mar. 2021

  医の倫理委員会　委員
• From 01 Apr. 2018, To 31 Mar. 2021

  ウイルス感染症・生命科学先端融合的共同研究拠点運営委員会　委員
• From 01 Apr. 2018, To 31 Mar. 2021

  ウイルス感染症・生命科学先端融合的共同研究拠点専門委員会　委員

Academic, Social Contribution

Committee Memberships

• From Apr. 2019, To Mar. 2020

  先端科学(FoS)シンポジウム事業委員会専門委員
• From Mar. 2016, To Feb. 2017

  先端科学(FoS)シンポジウム事業委員会プラニング・グループ・メンバー
• From Feb. 2011, To Jan. 2013

  先端科学(FoS)シンポジウム事業委員会プラニング・グループ・メンバー
• From Jun. 2023, To Present

  学術委員, アステラス病態代謝研究会
• From Jun. 2022, To Present

  さきがけ「加齢変容」アドバイザー, JST
• From May 2019, To Mar. 2025

  再生医療実現拠点ネットワークプログラム 幹細胞再生医学イノベーション創出プログラム プログラムオフィサー(PO), AMED