Basic Information

Email Address

• Email Address

  amita.hidetoshi.7xkyoto-u.ac.jp

Professional Memberships

• From 2025, To Present

  Primate Society of Japan
• From 2019, To Present

  Japan Basal Ganglia Society (JBAGS)
• From 2010, To Present

  Society for Neuroscience
• From 2010, To Present

  The Japan Neuroscience Society

Academic Degree

• M.S., Life Science(Hokkaido University)
• Ph.D., Life Science(Hokkaido University)

Academic Resume (Graduate Schools)

• Hokkaido University, Graduate School of Life Science, 修了

Research History

• From Apr. 2024, To Present

  Kyoto University, Center for the Evolutionary Origins of Human Behavior, Program-Specific Associate Professor
• From Apr. 2019, To Mar. 2024

  Kyoto University, Primate Research Institute, Program-Specific Assistant Professor
• From Jul. 2013, To Mar. 2019

  National Institutes of Health (NIH), National Eye Institute (NEI), Research fellow
• From Apr. 2013, To Jun. 2013

  Hokkaido University, Graduate School of Life Science, Research fellow
• From Apr. 2010, To Mar. 2013

  Japan Society for the Promotion of Science, Research fellow

Profile

• Profile

  Our brains regulate our minds and bodies based on our experiences and circumstances. However, the neuronal mechanisms that govern them are still not fully understood. Understanding these mechanisms could pave the way for the development of therapies. My aim is to comprehend primate brain functions and mechanisms by recording neuronal signals in non-human primates.

ID,URL

• ORCID ID

  0000-0002-8809-064X

• J-Global ID

  201101066235872355

• External link

  https://kdb.iimc.kyoto-u.ac.jp/profile_private/ja.b91602cb4d4ce2b3.html

Website(s) (URL(s))

• https://www.pri.kyoto-u.ac.jp/sections/systems_neuroscience/member.html

researchmap URL

• https://researchmap.jp/amita

Research

Research Topics, Overview of the research

• Research Topics

  Neuronal networks for governing cognitive and executive functions in primates

• Overview of the research

  Our brains regulate our minds and bodies based on our experiences and circumstances. However, the neuronal mechanisms that govern them are still not fully understood. Understanding these mechanisms could pave the way for the development of therapies. My aim is to comprehend primate brain functions and mechanisms by recording neuronal signals in non-human primates.

Research Interests

• Monkey
• Intelligence
• Mind
• Shitsukan
• Parkinson's disease
• Dementia with Lewy bodies
• Frontal lobe syndrome
• Frontal cortex
• Attention
• Systems neuroscience
• Behavioral ecology
• Optogenetics
• Basal ganglia
• Cognition
• Decision making
• Learning
• Primates
• Avian
• Evolution
• Comprehensive brain science network
• Dopamine
• Fluorescence imaging

Research Areas

• Life sciences, Neuroscience - general
• Life sciences, Nervous system function

Papers

• Fluorescence detection of dopamine signaling to the primate striatum in relation to stimulus–reward associations

  Gaoge Yan; Hidetoshi Amita; Satoshi Nonomura; Ken-ichi Inoue; Wolfram Schultz; Masahiko Takada

  Proceedings of the National Academy of Sciences, 13 Mar. 2025, Peer-reviewed, Lead author, Corresponding author

  
• Neuronal response of the primate striatum tail to face of socially familiar persons

  Jun Kunimatsu; Hidetoshi Amita; Okihide Hikosaka

  iScience, Jun. 2024, Peer-reviewed

  Access this paper :

  
• Neuronal Mechanisms Underlying Face Recognition in Non‐human Primates

  Hidetoshi Amita; Kenji W. Koyano; Jun Kunimatsu

  Japanese Psychological Research, Oct. 2024, Peer-reviewed, Lead author, Corresponding author

  
• An Open Resource for Non-human Primate Optogenetics

  Sébastien Tremblay; Leah Acker; Arash Afraz; Daniel L. Albaugh; Hidetoshi Amita; Ariana R. Andrei; Alessandra Angelucci; Amir Aschner; Puiu F. Balan; Michele A. Basso; Giacomo Benvenuti; Martin O. Bohlen; Michael J. Caiola; Roberto Calcedo; James Cavanaugh; Yuzhi Chen; Spencer Chen; Mykyta M. Chernov; Andrew M. Clark; Ji Dai; Samantha R. Debes; Karl Deisseroth; Robert Desimone; Valentin Dragoi; Seth W. Egger; Mark A.G. Eldridge; Hala G. El-Nahal; Francesco Fabbrini; Frederick Federer; Christopher R. Fetsch; Michal G. Fortuna; Robert M. Friedman; Naotaka Fujii; Alexander Gail; Adriana Galvan; Supriya Ghosh; Marc Alwin Gieselmann; Roberto A. Gulli; Okihide Hikosaka; Eghbal A. Hosseini; Xing Hu; Janina Hüer; Ken-ichi Inoue; Roger Janz; Mehrdad Jazayeri; Rundong Jiang; Niansheng Ju; Kohitij Kar; Carsten Klein; Adam Kohn; Misako Komatsu; Kazutaka Maeda; Julio C. Martinez-Trujillo; Masayuki Matsumoto; John H.R. Maunsell; Diego Mendoza-Halliday; Ilya E. Monosov; Ross S. Muers; Lauri Nurminen; Michael Ortiz-Rios; Daniel J. O’Shea; Stéphane Palfi; Christopher I. Petkov; Sorin Pojoga; Rishi Rajalingham; Charu Ramakrishnan; Evan D. Remington; Cambria Revsine; Anna W. Roe; Philip N. Sabes; Richard C. Saunders; Hansjörg Scherberger; Michael C. Schmid; Wolfram Schultz; Eyal Seidemann; Yann-Suhan Senova; Michael N. Shadlen; David L. Sheinberg; Caitlin Siu; Yoland Smith; Selina S. Solomon; Marc A. Sommer; John L. Spudich; William R. Stauffer; Masahiko Takada; Shiming Tang; Alexander Thiele; Stefan Treue; Wim Vanduffel; Rufin Vogels; Matthew P. Whitmire; Thomas Wichmann; Robert H. Wurtz; Haoran Xu; Azadeh Yazdan-Shahmorad; Krishna V. Shenoy; James J. DiCarlo; Michael L. Platt

  Neuron, Dec. 2020, Peer-reviewed

  
• Optogenetic manipulation of a value-coding pathway from the primate caudate tail facilitates saccadic gaze shift

  Hidetoshi Amita; Hyoung F Kim; Ken-ichi Inoue; Masahiko Takada; Okihide Hikosaka

  Nature communications, 20 Apr. 2020, Peer-reviewed, Lead author, Corresponding author

  Access this paper :

  
• Multiple neuronal circuits for variable object-action choices based on short- and long-term memories

  Okihide Hikosaka; Masaharu Yasuda; Kae Nakamura; Masaki Isoda; Hyoung F Kim; Yasuo Terao; Hidetoshi Amita; Kazutaka Maeda

  Proceedings of the National Academy of Sciences, 23 Dec. 2019, Peer-reviewed

  
• Indirect pathway from caudate tail mediates rejection of bad objects in periphery

  Hidetoshi Amita; Okihide Hikosaka

  Science advances, Aug. 2019, Peer-reviewed, Lead author, Corresponding author

  
• Direct and indirect pathways for choosing objects and actions

  Okihide Hikosaka; Hyoung F Kim; Hidetoshi Amita; Masaharu Yasuda; Masaki Isoda; Yoshihisa Tachibana; Atsushi Yoshida

  European Journal of Neuroscience, Mar. 2019, Peer-reviewed

  
• Neuronal connections of direct and indirect pathways for stable value memory in caudal basal ganglia

  Hidetoshi Amita; Hyoung F Kim; Mitchell K Smith; Atul Gopal; Okihide Hikosaka

  European Journal of Neuroscience, Mar. 2019, Peer-reviewed, Lead author, Corresponding author

  
• Ecological validity of impulsive choice: consequences of profitability-based short-sighted evaluation in the producer-scrounger resource competition

  Yukiko Ogura; Hidetoshi Amita; Toshiya Matsushima

  Frontiers in applied mathematics and statistics, Oct. 2018, Peer-reviewed

  
• Visual Neurons in the Superior Colliculus Discriminate Many Objects by Their Historical Values

  Whitney S Griggs; Hidetoshi Amita; Atul Gopal; Okihide Hikosaka

  Frontiers in Neuroscience, 11 Jun. 2018, Peer-reviewed

  
• Parallel basal ganglia circuits for decision making

  Okihide Hikosaka; Ali Ghazizadeh; Whitney Griggs; Hidetoshi Amita

  Journal of Neural Transmission, Mar. 2018, Peer-reviewed

  
• Indirect Pathway of Caudal Basal Ganglia for Rejection of Valueless Visual Objects

  Hyoung F. Kim; Hidetoshi Amita; Okihide Hikosaka

  Neuron, May 2017, Peer-reviewed

  
• Neuronal codes for the inhibitory control of impulsive actions in the rat infralimbic cortex

  Iku Tsutsui-Kimura; Yu Ohmura; Takeshi Izumi; Toshiya Matsushima; Hidetoshi Amita; Taku Yamaguchi; Takayuki Yoshida; Mitsuhiro Yoshioka

  Behavioural Brain Research, Jan. 2016, Peer-reviewed

  
• Competitor suppresses neuronal representation of food reward in the nucleus accumbens/medial striatum of domestic chicks

  Hidetoshi Amita; Toshiya Matsushima

  Behavioural Brain Research, Jul. 2014, Peer-reviewed, Lead author

  
• Behavioural and pharmacological effects of fluvoxamine on decision-making in food patches and the inter-temporal choices of domestic chicks

  Shohei Matsunami; Yukiko Ogura; Hidetoshi Amita; Takeshi Izumi; Mitsuhiro Yoshioka; Toshiya Matsushima

  Behavioural Brain Research, Aug. 2012, Peer-reviewed

  
• Instantaneous and cumulative influences of competition on impulsive choices in domestic chicks

  Hidetoshi Amita; Toshiya Matsushima

  Frontiers in Neuroscience, 2011, Peer-reviewed, Lead author

  
• Social influences of competition on impulsive choices in domestic chicks

  Hidetoshi Amita; Ai Kawamori; Toshiya Matsushima

  Biology Letters, Apr. 2010, Peer-reviewed, Lead author

  

Misc.

• Competitive foraging enhances impulsive choices in domestic chicks

  Hidetoshi Amita

  Neuroscience Research, Aug. 2010

  
• 瞬時に良いものを見つける”視覚探索スキル”の脳内メカニズムとは？ – サルの行動実験と神経回路から探る

  網田 英敏

  academist Journal, 24 Jun. 2020, Invited, Lead author, Corresponding author

  
• Complex social ecology needs complex machineries of foraging.

  Matsushima T; Amita H; Ogura Y

  The Behavioral and brain sciences, Jan. 2019, Peer-reviewed, Invited

  
• The neuronal circuits for foraging behavior: How do we find good items?

  AMITA Hidetoshi; HIKOSAKA Okihide

  Hikaku seiri seikagaku(Comparative Physiology and Biochemistry), 2018, Peer-reviewed, Invited

  
• Impulsiveness, Synchrony and Social Facilitation

  MATSUSHIMA Toshiya; WEN Chentao; OGURA Yukiko; AMITA Hidetoshi

  計測と制御 = Journal of the Society of Instrument and Control Engineers, 10 Mar. 2013, Peer-reviewed, Invited

  
• 「朝三暮四」は誤謬? : それとも適応?

  網田 英敏

  比較生理生化学, 30 Dec. 2010, Invited

  
• ASCONE08体験記

  網田 英敏

  日本神経回路学会誌 = The Brain & neural networks, 05 Jun. 2009, Invited

  
• IBRO-ANS Advanced Neuroscience School 参加記

  網田 英敏

  比較生理生化学, 20 Apr. 2009, Invited

  
• Long-term modification of choice impulsiveness by competitive foraging and the medial striatum/nucleus accumbens of domestic cihcks

  AMITA H.

  10th International Congress of Neuroethology, (Abstract), August, Maryland, USA, 2012, 2012

  

Presentations

• Dopamine signaling to the primate striatum in stimulus-reward associations

  Hidetoshi Amita

  Tohoku University, "Reward, Motivation, and Beyond: Neural Basis of Communication, Part 2", Workshop on the Systems Neuroscience Approach, 13 Oct. 2024, Invited

  
• サル線条体に入力する多様なドーパミン信号

  網田 英敏

  生理研研究会 霊長類ニューロサイエンス研究会, 08 Aug. 2024, Invited

  
• ドーパミン蛍光イメージング技術の霊長類脳への適用

  網田 英敏

  第4回 サル脳新技術研究会, 24 Feb. 2023, Invited

  
• なぜ好きなものに目がいくのか?

  網田 英敏

  日本動物学会北海道支部第571回支部講演会, 13 Apr. 2017, Invited

  
• 適切な行動を生み出す大脳基底核ネットワーク

  網田 英敏

  第272回 つくばブレインサイエンス・セミナー, 20 Dec. 2022, Invited

  
• Multiple functional dopamine-basal ganglia circuits in primates

  Hidetoshi Amita

  Japan and Norway United in Brain, Educations and Therapeutics Symposium, 21 Sep. 2022, Invited

  
• The role of perineuronal nets in the substantia nigra pars lateralis in object skill learning

  Hidetoshi Amita; Tamaki Takayasu; Gaoge Yan; Okihide Hikosaka; Masahiko Takada

  The 44th Annual Meeting of the Japan Neuroscience Society / the 1st CJK International Meeting, 30 Jul. 2021, Invited

  
• The role of the substantia nigra pars lateralis in object skill learning

  Hidetoshi Amita

  The 10th NIPS-PRI-BRINU Joint Symposium, 12 Mar. 2021, Invited

  
• 価値に基づく眼球運動を制御する大脳基底核神経路

  Hidetoshi Amita

  生理研研究会 2019「行動の多様性を支える神経基盤とその動作様式の解明」, 13 Dec. 2019, Invited

  
• 報酬価値にもとづくサッケードを生み出す基底核神経路メカニズム

  網田 英敏; 彦坂興秀

  第34回 日本大脳基底核研究会, 25 Aug. 2019

  
• Pathway-selective optogenetic modulation of value-biased saccade circuits in the monkey basal ganglia

  Hidetoshi Amita; Hyoung F. Kim; Ken-Ichi Inoue; Masahiko Takada; Okihide Hikosaka

  The 41st Annual Meeting of the Japan Neuroscience Society, 29 Jul. 2018, Invited

  
• Optogenetic modulation of saccade-controlling circuits in the monkey basal ganglia

  Hidetoshi Amita; Hyoung F. Kim; Kenichi Inoue; Masahiko Takada; Okihide Hikosaka

  Neuroscience 2017, 14 Nov. 2017

  
• Direct and indirect pathways from caudate tail, together, guide saccadic eye movement to historically good objects

  Hidetoshi Amita; Hyoung F. Kim; Whitney Griggs; Okihide Hikosaka

  12th International Basal Ganglia Society Meeting, 28 Mar. 2017

  
• Direct and indirect pathways in basal ganglia signaling opposite reward values: anatomical study

  Hidetoshi Amita; Hyoung F. Kim; Whitney Griggs; Ali Ghazizadeh; Okihide Hikosaka

  Neuroscience 2016, 15 Nov. 2016

  
• Habitual saccades aiming at valuable objects - a role of basal ganglia

  Hidetoshi Amita; Okihide Hikosaka

  Neuroscience 2015, 18 Oct. 2015

  

Books and Other Publications

• Handbook of Shitsukan science

  小松, 英彦; 富永, 昌二; 西田, 眞也, Contributor, 質感認知の脳神経機構: 報酬系

  東京大学出版会, Jan. 2025

  Find Kyoto University's collection of books :

  
• Journal of Clinical and Experimental Medicine (IGAKU NO AYUMI)

  網田英敏, Contributor, The Evolution of Primate Behavior and Neuroeconomics

  医歯薬出版, Apr. 2024

  
• Annual Review神経2021

  鈴木, 則宏; 荒木, 信夫; 宇川, 義一; 桑原, 聡; 塩川, 芳昭, Contributor, 尾状核細胞の報酬表現

  中外医学社, Jun. 2021

  Find Kyoto University's collection of books :

  
• 研究者が教える動物実験 第2巻 神経・筋

  尾崎, まみこ; 村田, 芳博; 藍, 浩之; 定本, 久世; 吉村, 和也; 神崎, 亮平; 日本比較生理生化学会, Contributor, ニューロンの声を聞いてみよう（ニワトリ雛（ヒヨコ））ー可動式ワイヤー電極による単一ニューロン活動記録法ー

  共立出版, Jul. 2015

  Find Kyoto University's collection of books :

  

External funds: Kakenhi

• Pathway-selective chemogenetic manipulation of judgement behaviors

  Grant-in-Aid for Early-Career Scientists

  Basic Section 46030:Function of nervous system-related

  Kyoto University

  Hidetoshi Amita

  From 01 Apr. 2020, To 31 Mar. 2022, Project Closed

  神経科学;霊長類;大脳基底核;報酬;ドーパミン;価値;予測;ウイルスベクター;長期学習;短期学習

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K15930/
• Elucidation of the neural mechanism for Shitsukan-value translations

  Grant-in-Aid for Transformative Research Areas (A)

  Transformative Research Areas, Section (IV)

  National Institutes for Quantum Science and Technology

  南本 敬史

  From 19 Nov. 2020, To 31 Mar. 2025, Granted

  質感;価値;好み;サル;神経活動操作;神経活動操作技術

  https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-20H05955/
• Basal ganglia circuits for controlling routine and context-based behaviors

  Grant-in-Aid for Research Activity Start-up

  0704:Neuroscience, brain sciences, and related fields

  Kyoto University

  Hidetoshi Amita

  From 30 Aug. 2019, To 31 Mar. 2021, Project Closed

  神経科学;霊長類;スキル;黒質外側部;ペリニューロナルネット;コンドロイチナーゼ;タッチパネル;記憶;大脳基底核;ルーティン;ベクター;化学遺伝学

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K23778/
• Investigation of dopamine sensory prediction error

  Grant-in-Aid for Scientific Research (C)

  Basic Section 46030:Function of nervous system-related

  Kyoto University

  網田 英敏

  From 01 Apr. 2022, To 31 Mar. 2025, Granted

  神経科学;大脳基底核;報酬予測誤差;ドーパミン;霊長類;予測;価値;ウイルスベクター;認知;連合学習;感覚

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K06484/

External funds: others

• Development of Fluorescence Imaging Tools and Elucidation of Frontostriatal Pathways in Non-Human Primates

  The Japan Agency for Medical Research and Development (AMED), The Brain/MINDS 2.0

  From 01 Aug. 2024, To 31 Mar. 2027

  Hidetoshi Amita

  代表
• 霊長類モデル動物を用いた脳神経機能及びその疾患に関する基盤的研究

  National Center of Neurology and Psychiatry, 精神・神経疾患研究開発事業

  From 01 Apr. 2023, To 31 Mar. 2026

  Kazuhiko Seki

  Hidetoshi Amita

  分担
• Neural mechanisms of motor learning

  The Japan Agency for Medical Research and Development (AMED), Interstellar Initiative

  From 31 Oct. 2022, To 31 Mar. 2023

  Hidetoshi Amita

  Adeel Razi, Robert Matthew

  代表
• The treatment of Parkinson's disease by optogenetic tools

  Takeda Science Foundation, Life Science Research Grants

  From 01 Aug. 2020, To 30 Apr. 2023

  Hidetoshi Amita

  代表
• Investigation of basal ganglia mechanisms for motor and cognitive skills

  The Uehara Memorial Foundation, Research incentive grants

  From 01 Jan. 2020, To 30 Apr. 2021

  Hidetoshi Amita

  代表

Education

Student achievements: Awards

• Best Paper Award 2024

  Gaoge Yan, Center for the Evolutionary Origins of Human Behavior (EHUB), Kyoto University, 09 Apr. 2025

Student achievements: Papers

• Fluorescence detection of dopamine signaling to the primate striatum in relation to stimulus–reward associations

  Gaoge Yan, Hidetoshi Amita, Satoshi Nonomura, Ken-ichi Inoue, Wolfram Schultz, Masahiko Takada

  18 Mar. 2025, Proceedings of the National Academy of Sciences of the United States of America, 122, 11, e2426861122, Peer-reviewed, English, Scientific journal, True

  https://doi.org/10.1073/pnas.2426861122

Student achievements: Presentations

• A fluorescent dopamine sensor reveals distinct signals on reward prediction error and expected reward value in the primate putamen and caudate nucleus

  Yan G., Amita H., Nonomura S., Inoue K., Takada M.

  XIVth Meeting for International Basal Ganglia Society, 14 Jun. 2023, From 13 Jun. 2023, To 16 Jun. 2023, English, Poster presentation
• Distinct patterns of dopamine responses to reward association in primate caudate nucleus and putamen as revealed by dLight signals

  Yan G., Amita H., Nonomura S., Inoue K., Takada M.

  Neuroscience 2022, 14 Nov. 2022, From 11 Nov. 2022, To 15 Nov. 2022
• Fluorescent sensor reveals dopamine dynamics in the primate striatum

  Yan G., Amita H., Nonomura S., Inoue K., Takada M.

  The 45th Annual Meeting of the Japan Neuroscience Society, 02 Jul. 2022, From 30 Jun. 2022, To 03 Jul. 2022

Other educational achievements

• 2019年　ILASセミナー：霊長類脳神経科学トレーニングコース
• 2022年　ILASセミナー：霊長類脳神経科学トレーニングコース
• 2024年　ILASセミナー：霊長類脳神経科学トレーニングコース

Academic, Social Contribution

Academic Contribution

• NIPS workshop 2022

  Planning, management, etc.

  Hidetoshi Amita, Taihei Ninomiya, Masaki Isoda, From 26 Sep. 2022, To 27 Sep. 2022

  
• Neural processing of flexible vs. automatic behavior in primates

  Planning, management, etc., Panel moderator

  Jun Kunimatsu, Hidetoshi Amita, From 30 Jul. 2021, To 30 Jul. 2021

  
• The 2nd workshop on manipulation and imaging of primate brain functions

  Planning, management, etc.

  Hidetoshi Amita, Takafumi Minamimoto, Ken-ichi Inoue, From 27 Feb. 2021, To 27 Feb. 2021