Basic Information

Faculty

• 薬学部

Academic Degree

• 修士（薬学）(京都大学)
• 博士（薬学）(京都大学)

Academic Resume (Graduate Schools)

• 京都大学, 大学院薬学研究科修士課程医療薬科学専攻, 修了
• 京都大学, 大学院薬学研究科博士後期課程医療薬科学専攻, 修了

Research History

• Kyoto University Graduate School of Pharmaceutical Sciences Division of Pharmacy and Biomedicinal Sciences

ID,URL

• ORCID ID

  0000-0002-9869-1019

• J-Global ID

  200901087230838603

• Researcher number

  40402797

researchmap URL

• https://researchmap.jp/read0095551

Research

Research Areas

• Life sciences, Clinical pharmacy
• Life sciences, Biomedical engineering

Papers

• Protective role of hepatic non-parenchymal cells against drug-induced hepatocyte toxicity using perfluoropolyether-based microfluidic devices.

  Mengyang Wang; Qiyue Zhang; Kazuma Aoki; Yuriko Higuchi; Fumiyoshi Yamashita

  Toxicology letters, 01 May 2025, Peer-reviewed

  
• 経口バイオアベイラビリティー評価のための腸肝連結マイクロ流体チップの開発

  山下 富義; 王 夢洋; 津田 真弘; 樋口 ゆり子; 高山 和雄

  日本薬剤学会年会講演要旨集, May 2023

  
• Programmed immobilization of living cells using independent click pairs

  Chengyuan Zhu; Hiroyasu Takemoto; Yuriko Higuchi; Fumiyoshi Yamashita

  Biochemical and Biophysical Research Communications, 05 Mar. 2024

  
• Perfluoropolyether-Based Gut-Liver-on-a-Chip for the Evaluation of First-Pass Metabolism and Oral Bioavailability of Drugs

  Mengyang Wang; Yuko Sasaki; Rena Sakagami; Tomotaka Minamikawa; Masahiro Tsuda; Ryohei Ueno; Sayaka Deguchi; Ryosuke Negoro; Kanako So; Yuriko Higuchi; Ryuji Yokokawa; Kazuo Takayama; Fumiyoshi Yamashita

  ACS Biomaterials Science and Engineering, 2024

  
• Video-rate imaging of luminescent tumour cells in freely moving unshaved mice

  Takeharu Nagai; Kenta Saito; Yuriko Higuchi; Yoshiyuki Arai; Takeharu Nagai

  Protocol Exchange, 18 Feb. 2013

  
• Application of perfluoropolyether elastomers in microfluidic drug metabolism assays.

  Mengyang Wang; Masahiro Tsuda; Sayaka Deguchi; Yuriko Higuchi; Kanako So; Yu-Suke Torisawa; Kazuo Takayama; Fumiyoshi Yamashita

  International journal of pharmaceutics, 05 Nov. 2022

  
• Disposition of E-selectin-targeting liposomes in tumor spheroids with a perfusable vascular network.

  Chanikarn Chantarasrivong; Ryu Okada; Yuuki Yamane; Xue Yang; Yuriko Higuchi; Miku Konishi; Naoko Komura; Hiromune Ando; Ryuji Yokokawa; Fumiyoshi Yamashita

  Drug metabolism and pharmacokinetics, 07 Aug. 2022

  
• Intestinal Permeability of Drugs in Caco-2 Cells Cultured in Microfluidic Devices.

  Yuko Sasaki; Hirotaka Tatsuoka; Masahiro Tsuda; Takumi Sumi; Yuka Eguchi; Kanako So; Yuriko Higuchi; Kazuo Takayama; Yusuke Torisawa; Fumiyoshi Yamashita

  Biological & pharmaceutical bulletin, 2022

  
• CREB is a potential marker associated with drug-induced liver injury: Identification and validation through transcriptome database analysis

  Qiyue Zhang; Shiori Taniguchi; Kanako So; Masahiro Tsuda; Yuriko Higuchi; Mitsuru Hashida; Fumiyoshi Yamashita

  JOURNAL OF TOXICOLOGICAL SCIENCES, 2022

  
• In Vivo Cell Trafficking by Functional Quantum Dots

  HIGUCHI Yuriko

  rle, 15 Jun. 2010

  
• Prediction of HIV drug resistance based on the 3D protein structure: Proposal of molecular field mapping.

  Ryosaku Ota; Kanako So; Masahiro Tsuda; Yuriko Higuchi; Fumiyoshi Yamashita

  PloS one, 2021

  
• [Cell Editing: Control of Cell Function Utilizing Biomaterials Based on Collaborative Researches between Medicine, Pharmaceutical Sciences, and Engineering].

  Akihiro Kishimura; Yuriko Higuchi

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2021

  
• [Controlling Cell Dynamics by Cell-surface Modification].

  Yuriko Higuchi; Yoshimasa Takafuji

  Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2021

  
• PD-L1/L2 protein levels rapidly increase on monocytes via trogocytosis from tumor cells in classical Hodgkin lymphoma.

  Masaharu Kawashima; Joaquim Carreras; Hiroshi Higuchi; Ryutaro Kotaki; Takahiro Hoshina; Kazuki Okuyama; Naoto Suzuki; Masatoshi Kakizaki; Yuji Miyatake; Kiyoshi Ando; Masafumi Nakayama; Shinjiro Umezu; Ryouichi Horie; Yuriko Higuchi; Koko Katagiri; Susumu Goyama; Toshio Kitamura; Kenji Chamoto; Shingo Yano; Naoya Nakamura; Ai Kotani

  Leukemia, Sep. 2020

  
• ディープ・ニューラルネットワークを組み込んだ母集団薬物動態モデルの開発

  山下 富義; 太田 亮作; 津田 真弘; 樋口 ゆり子

  日本薬学会年会要旨集, Mar. 2020

  
• A model-based comparative meta-analysis of the efficacy of dolutegravir-based and efavirenz-based regimens in HIV-infected patients.

  Ryosaku Ota; Hiromu Ishii; Masahiro Tsuda; Yuriko Higuchi; Fumiyoshi Yamashita

  Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, Sep. 2019, Peer-reviewed

  
• Development of mKO2 fusion proteins for real-time imaging and mechanistic investigation of the degradation kinetics of human IκBα in living cells.

  Nilufar Rahimova; Hasan Babazada; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  Biochimica et biophysica acta. Molecular cell research, Feb. 2019, Peer-reviewed

  
• An Evolutionary Search Algorithm for Covariate Models in Population Pharmacokinetic Analysis.

  Fumiyoshi Yamashita; Atsuto Fujita; Yukako Sasa; Yuriko Higuchi; Masahiro Tsuda; Mitsuru Hashida

  Journal of pharmaceutical sciences, Sep. 2017, Peer-reviewed

  
• Synthesis and Functional Characterization of Novel Sialyl LewisX Mimic-Decorated Liposomes for E-selectin-Mediated Targeting to Inflamed Endothelial Cells.

  Chanikarn Chantarasrivong; Akiharu Ueki; Ryutaro Ohyama; Johan Unga; Shinya Nakamura; Isao Nakanishi; Yuriko Higuchi; Shigeru Kawakami; Hiromune Ando; Akihiro Imamura; Hideharu Ishida; Fumiyoshi Yamashita; Makoto Kiso; Mitsuru Hashida

  Molecular pharmaceutics, 01 May 2017, Peer-reviewed

  
• Anti-inflammatory Effect of Self-assembling Glycol-Split Glycosaminoglycan-Stearylamine Conjugates in Lipopolysaccharide-Stimulated Macrophages

  Shinya Yanamoto; Hasan Babazada; Shinya Sakai; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Apr. 2017, Peer-reviewed

  
• In Vitro Cellular Gene Delivery Employing a Novel Composite Material of Single-Walled Carbon Nanotubes Associated With Designed Peptides With Pegylation

  Takahisa Ohta; Yasuhiko Hashida; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF PHARMACEUTICAL SCIENCES, Mar. 2017, Peer-reviewed

  
• Use of Membrane Potential to Achieve Transmembrane Modification with an Artificial Receptor

  Wataru Hatanaka; Miki Kawaguchi; Xizheng Sun; Yusuke Nagao; Hiroyuki Ohshima; Mitsuru Hashida; Yuriko Higuchi; Akihiro Kishimura; Yoshiki Katayama; Takeshi Mori

  BIOCONJUGATE CHEMISTRY, Feb. 2017, Peer-reviewed

  
• The development of mechanically formed stable nanobubbles intended for sonoporation-mediated gene transfection

  Rodi Abdalkader; Shigeru Kawakami; Johan Unga; Yuriko Higuchi; Ryo Suzuki; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  DRUG DELIVERY, 2017, Peer-reviewed

  
• Development of drug delivery system and imaging technique

  Yuriko Higuchi

  Drug Delivery System, 2016, Peer-reviewed

  
• Intravital imaging of live mice at cellular resolution

  Sota Yamada; Yuriko Higuchi; Mitsuru Hashida

  Drug Delivery System, 2016, Peer-reviewed

  
• Development of fluorous lipid-based nanobubbles for efficiently containing perfluoropropane.

  Yusuke Oda; Ryo Suzuki; Tatsuya Mori; Hideyo Takahashi; Hideaki Natsugari; Daiki Omata; Johan Unga; Hitoshi Uruga; Mutsumi Sugii; Shigeru Kawakami; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida; Kazuo Maruyama

  International journal of pharmaceutics, 20 Jun. 2015, Peer-reviewed

  
• Systemic Targeting of Lymph Node Metastasis through the Blood Vascular System by Using Size-Controlled Nanocarriers.

  Horacio Cabral; Jun Makino; Yu Matsumoto; Peng Mi; Hailiang Wu; Takahiro Nomoto; Kazuko Toh; Naoki Yamada; Yuriko Higuchi; Satoshi Konishi; Mitsunobu R Kano; Hiroshi Nishihara; Yutaka Miura; Nobuhiro Nishiyama; Kazunori Kataoka

  ACS nano, 26 May 2015, Peer-reviewed

  
• Real time imaging of biological phenomena with super-duper luminescent proteins

  Kenta Saito; Yu Fen Chang; Kazuki Horikawa; Yuriko Higuchi; Mitsuru Hashida; Tomoki Matsuda; Yoshiyuki Arai; Takeharu Nagai

  Cytologia, 01 Jan. 2015

  
• Kidney-selective gene transfection using anionic bubble lipopolyplexes with renal ultrasound irradiation in mice

  Tomoaki Kurosaki; Shigeru Kawakami; Yuriko Higuchi; Ryo Suzuki; Kazuo Maruyama; Hitoshi Sasaki; Fumiyoshi Yamashita; Mitsuru Hashida

  NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, Nov. 2014, Peer-reviewed

  
• Enhancement of the anti-tumor effect of DNA vaccination using an ultrasound-responsive mannose-modified gene carrier in combination with doxorubicin-encapsulated PEGylated liposomes

  Mitsuru Yoshida; Shigeru Kawakami; Yusuke Kono; Keita Un; Yuriko Higuchi; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Nov. 2014, Peer-reviewed

  
• Evaluation of inflammatory responses due to small interfering RNA transfer using unmodified- and mannose-modified bubble lipoplexes with ultrasound exposure in primary cultured macrophages

  Mitsuru Yoshida; Shigeru Kawakami; Keita Un; Yusuke Kono; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF DRUG TARGETING, Sep. 2014, Peer-reviewed

  
• Targeted gene integration using the combination of a sequence-specific DNA-binding protein and phiC31 integrase

  Hideyuki Nakanishi; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF BIOTECHNOLOGY, Sep. 2014, Peer-reviewed

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• Neutralized nanoparticle composed of SS-cleavable and pH-activated lipid-like material as a long-lasting and liver-specific gene delivery system.

  Masami Ukawa; Hidetaka Akita; Yasuhiro Hayashi; Ryohei Ishiba; Kota Tange; Masaya Arai; Kazuhiro Kubo; Yuriko Higuchi; Kazunori Shimizu; Satoshi Konishi; Mitsuru Hashida; Hideyoshi Harashima

  Advanced Healthcare Materials, 14 Aug. 2014, Peer-reviewed

  
• Neutralized Nanoparticle Composed of SS-Cleavable and pH-Activated Lipid-Like Material as a Long-Lasting and Liver-Specific Gene Delivery System

  Masami Ukawa; Hidetaka Akita; Yasuhiro Hayashi; Ryohei Ishiba; Kota Tange; Masaya Arai; Kazuhiro Kubo; Yuriko Higuchi; Kazunori Shimizu; Satoshi Konishi; Mitsuru Hashida; Hideyoshi Harashima

  ADVANCED HEALTHCARE MATERIALS, Aug. 2014, Peer-reviewed

  
• Antitumor effect of nuclear factor-B decoy transfer by mannose-modified bubble lipoplex into macrophages in mouse malignant ascites

  Yusuke Kono; Shigeru Kawakami; Yuriko Higuchi; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  CANCER SCIENCE, Aug. 2014, Peer-reviewed

  
• Tumour-associated macrophages targeted transfection with NF-kappa B decoy/mannose-modified bubble lipoplexes inhibits tumour growth in tumour-bearing mice

  Yusuke Kono; Shigeru Kawakami; Yuriko Higuchi; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF DRUG TARGETING, Jun. 2014, Peer-reviewed

  
• Development of anionic bubble lipopolyplexes for efficient and safe gene transfection with ultrasound exposure in mice

  Tomoaki Kurosaki; Shigeru Kawakami; Yuriko Higuchi; Ryo Suzuki; Kazuo Maruyama; Hitoshi Sasaki; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Feb. 2014, Peer-reviewed

  
• In Vitro Evaluation of Inhibitory Effect of Nuclear Factor-KappaB Activity by Small Interfering RNA on Pro-tumor Characteristics of M2-Like Macrophages

  Yusuke Kono; Shigeru Kawakami; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jan. 2014, Peer-reviewed

  
• Factors Influencing the Surface Modification of Mesenchymal Stem Cells with Fluorescein-Pegylated Lipids

  Yoshimasa Takafuji; Yuriko Higuchi; Atsushi Muro; Kohei Oshiro; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Nov. 2013, Peer-reviewed

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• Development of optical imaging to visualize dynamics of cells in vivo

  Yuriko Higuchi

  Drug Delivery System, Apr. 2013, Peer-reviewed

  
• Luminescent proteins for high-speed single-cell and whole-body imaging

  Kenta Saito; Y. -F. Chang; Kazuki Horikawa; Noriyuki Hatsugai; Yuriko Higuchi; Mitsuru Hashida; Yu Yoshida; Tomoki Matsuda; Yoshiyuki Arai; Takeharu Nagai

  NATURE COMMUNICATIONS, Dec. 2012, Peer-reviewed

  
• Efficient suppression of murine intracellular adhesion molecule-1 using ultrasound-responsive and mannose-modified lipoplexes inhibits acute hepatic inflammation

  Keita Un; Shigeru Kawakami; Mitsuru Yoshida; Yuriko Higuchi; Ryo Suzuki; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  HEPATOLOGY, Jul. 2012, Peer-reviewed

  
• Evaluation of Long-Term Gene Expression in Mouse Liver Using PhiC31 Integrase and Hydrodynamic Injection

  Yoshiaki Umemoto; Shigeru Kawakami; Yuki Otani; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jul. 2012, Peer-reviewed

  
• Bovine Serum Albumin as a Lyoprotectant for Preparation of DNA Dry Powder Formulations Using the Spray-Freeze Drying Method

  Masashi Tsukamoto; Tomoyuki Okuda; Hirokazu Okamoto; Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jul. 2012, Peer-reviewed

  
• Photonics Meets Sensing of Bio-reaction and Cell Dynamics

  Yuriko Higuchi; Hidetaka Akita

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Apr. 2012, Peer-reviewed

  
• Development of Fluorescent Labeling Methods for Stem Cells

  Yuriko Higuchi

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Apr. 2012, Peer-reviewed

  
• Self-assemble gene delivery system for molecular targeting using nucleic acid aptamer

  Tomoaki Kurosaki; Norihide Higuchi; Shigeru Kawakami; Yuriko Higuchi; Tadahiro Nakamura; Takashi Kitahara; Mitsuru Hashida; Hitoshi Sasaki

  GENE, Jan. 2012, Peer-reviewed

  
• The involvement of NK cell activation following intranasal administration of CpG DNA lipoplex in the prevention of pulmonary metastasis and peritoneal dissemination in mice

  Shuwen Zhou; Shigeru Kawakami; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  CLINICAL & EXPERIMENTAL METASTASIS, Jan. 2012, Peer-reviewed

  
• Involvement of activated transcriptional process in efficient gene transfection using unmodified and mannose-modified bubble lipoplexes with ultrasound exposure

  Keita Un; Shigeru Kawakami; Yuriko Higuchi; Ryo Suzuki; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Dec. 2011, Peer-reviewed

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• Development of lysine-histidine dendron modified chitosan for improving transfection efficiency in HEK293 cells

  Kai-Ling Chang; Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Dec. 2011, Peer-reviewed

  
• Development of a suction device for stabilizing in vivo real-time imaging of murine tissues

  Kazunori Shimizu; Yuriko Higuchi; Yoshimasa Kozu; Mitsuru Hashida; Satoshi Konishi

  JOURNAL OF BIOSCIENCE AND BIOENGINEERING, Nov. 2011, Peer-reviewed

  
• Polyamidoamine dendrimer-conjugated quantum dots for efficient labeling of primary cultured mesenchymal stem cells

  Yuriko Higuchi; Can Wu; Kai-Ling Chang; Kei Irie; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOMATERIALS, Oct. 2011, Peer-reviewed

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• Comparison of piggyBac transposition efficiency between linear and circular donor vectors in mammalian cells

  Hideyuki Nakanishi; Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF BIOTECHNOLOGY, Jul. 2011, Peer-reviewed

  
• The elucidation of gene transferring mechanism by ultrasound-responsive unmodified and mannose-modified lipoplexes

  Keita Un; Shigeru Kawakami; Mitsuru Yoshida; Yuriko Higuchi; Ryo Suzuki; Kazuo Maruyama; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOMATERIALS, Jul. 2011, Peer-reviewed

  
• Development of polyamidoamine dendrimer-conjugated quantum dots for tracing primary cultured mesenchymal stem cells in mice

  Yuriko Higuchi; Wu Can; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  Molecular Therapy, Jun. 2011, Peer-reviewed

  
• Evaluation of Osteoclastogenesis via NF kappa B Decoy/mannosylated Cationic Liposome-Mediated Inhibition of Pro-inflammatory Cytokine Production from Primary Cultured Macrophages

  Thuy Duong Dinh; Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  PHARMACEUTICAL RESEARCH, Apr. 2011, Peer-reviewed

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• Intratracheally instilled mannosylated cationic liposome/NF kappa B decoy complexes for effective prevention of LPS-induced lung inflammation

  Wassana Wijagkanalan; Shigeru Kawakami; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Jan. 2011, Peer-reviewed

  
• Enhanced growth inhibition of metastatic lung tumors by intravenous injection of ATRA-cationic liposome/IL-12 pDNA complexes in mice

  P. Charoensit; S. Kawakami; Y. Higuchi; F. Yamashita; M. Hashida

  CANCER GENE THERAPY, Jul. 2010, Peer-reviewed

  
• Efficient Gene Transfection by Histidine-Modified Chitosan through Enhancement of Endosomal Escape

  Kai-Ling Chang; Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOCONJUGATE CHEMISTRY, Jun. 2010, Peer-reviewed

  
• piggyBac Transposon-mediated Long-term Gene Expression in Mice

  Hideyuki Nakanishi; Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  MOLECULAR THERAPY, Apr. 2010, Peer-reviewed

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• gamma-Polyglutamic acid-coated vectors for effective and safe gene therapy

  Tomoaki Kurosaki; Takashi Kitahara; Shigeru Kawakami; Yuriko Higuchi; Ayumi Yamaguchi; Hiroo Nakagawa; Yukinobu Kodama; Tomoyuki Hamamoto; Mitsuru Hashida; Hitoshi Sasaki

  JOURNAL OF CONTROLLED RELEASE, Mar. 2010, Peer-reviewed

  
• Strategies for In Vivo Delivery of siRNAs Recent Progress

  Yuriko Higuchi; Shigeru Kawakami; Mitsuru Hashida

  BIODRUGS, 2010, Peer-reviewed

  
• Development and Therapeutic Application of Transposon-based Vectors

  Hideyuki Nakanishi; Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Dec. 2009, Peer-reviewed

  
• Enhanced Gene Transfection in Macrophages by Histidine-Conjugated Mannosylated Cationic Liposomes

  Kazumi Nakamura; Yukari Kuramoto; Hidefumi Mukai; Shigeru Kawakami; Yuriko Higuchi; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Sep. 2009, Peer-reviewed

  
• NF kappa B decoy delivery using dendritic poly(L-lysine) for treatment of endotoxin-induced hepatitis in mice

  Yusuke Sugao; Kazuto Watanabe; Yuriko Higuchi; Ryohsuke Kurihara; Shigeru Kawakami; Mitsuru Hashida; Yoshiki Katayama; Takuro Niidome

  BIOORGANIC & MEDICINAL CHEMISTRY, Jul. 2009, Peer-reviewed

  
• Encapsulation of the synthetic retinoids Am80 and LE540 into polymeric micelles and the retinoids' release control

  Taku Satoh; Yuriko Higuchi; Shigeru Kawakami; Mitsuru Hashida; Hiroyuki Kagechika; Koichi Shudo; Masayuki Yokoyama

  JOURNAL OF CONTROLLED RELEASE, Jun. 2009, Peer-reviewed

  
• Enhanced in vivo antitumor efficacy of fenretinide encapsulated in polymeric micelles

  Tomoyuki Okuda; Shigeru Kawakami; Yuriko Higuchi; Taku Satoh; Yoshimi Oka; Masayuki Yokoyama; Fumiyoshi Yamashita; Mitsuru Hashida

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, May 2009, Peer-reviewed

  
• Glycosylated liposomes for the targeted delivery of siRNA and CpG DNA

  Shigeru Kawakami; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida

  Journal of Gene Medicine, Apr. 2009, Peer-reviewed

  
• Evaluation of proinflammatory cytokine production and liver injury induced by plasmid DNA/cationic liposome complexes with various mixing ratios in mice

  Yoshitaka Ito; Shigeru Kawakalni; Pensri Charoensit; Yuriko Higuchi; Mitsuru Hashida

  EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, Feb. 2009, Peer-reviewed

  
• Immunostimulatory Characteristics Induced by Linear Polyethyleneimine-Plasmid DNA Complexes in Cultured Macrophages

  Yasunori Saito; Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  HUMAN GENE THERAPY, Feb. 2009, Peer-reviewed

  
• Suppressive effects of sugar-modified cationic liposome/NF-kappa B decoy complexes on adenovirus vector-induced innate immune responses

  Haiying Huang; Fuminori Sakurai; Yuriko Higuchi; Shigeru Kawakami; Mitsuru Hashida; Kenji Kawabata; Hiroyuki Mizuguchi

  JOURNAL OF CONTROLLED RELEASE, Jan. 2009, Peer-reviewed

  
• Enhanced Anti-Inflammation of Inhaled Dexamethasone Palmitate Using Mannosylated Liposomes in an Endotoxin-Induced Lung Inflammation Model

  Wassana Wijagkanalan; Yuriko Higuchi; Shigeru Kawakami; Mugen Teshima; Hitoshi Sasaki; Mitsuru Hashida

  MOLECULAR PHARMACOLOGY, Nov. 2008, Peer-reviewed

  
• Kupffer cell targeted delivery of nfkb decoy suppress hepatic ishchemia/reperfusion injury

  Yuriko Higuchi; Can Wu; Shigeru Kawakami; Mitsuru Hashida

  JOURNAL OF GENE MEDICINE, Apr. 2008, Peer-reviewed

  
• Nonviral approaches for targeted delivery of plasmid DNA and oligonucleotide

  Shigeru Kawakami; Yuriko Higuchi; Mitsuru Hashida

  JOURNAL OF PHARMACEUTICAL SCIENCES, Feb. 2008, Peer-reviewed

  
• Development of cell-selective targeting systems of NF kappa B decoy for inflammation therapy

  Yuriko Higuchi; Shigeru Kawakami; Mitsuru Hashida

  YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, Feb. 2008, Peer-reviewed

  
• Incorporation of alt-trans retinoic acid into lipoplexes inhibits nuclear factor kappa B activation mediated liver injury induced by lipoplexes in mice

  Pensd Charoensit; Shigeru Kawakami; Yuriko Higuchi; Mitsuru Hashida

  JOURNAL OF GENE MEDICINE, Jan. 2008, Peer-reviewed

  
• Mannosylated semiconductor quantum dots for the labeling of macrophages

  Yuriko Higuchi; Machiko Oka; Shigeru Kawakami; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Jan. 2008, Peer-reviewed

  
• Development of cancer immune therapy by cell targeted nucleic acid delivery

  Kawakami S; Higuchi Y; Nakanishi H; Kuramoto Y; Hattori Y; Hashida M

  Drug Delivery System, 2008, Peer-reviewed

  
• Hepatocyte-selective gene transfer by galactosylated Protein/Linear Polyethyleneimine/Plasmid DNA complexes in mice

  Miyuki Hohokabe; Yuriko Higuchi; Hidefumi Mukai; Shigeru Kawakami; Mitsuru Hashida

  JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, Sep. 2007, Peer-reviewed

  
• Novel histidine-conjugated galactosylated cationic liposomes for efficient hepatocyte-selective gene transfer in human hepatoma HepG2 cells

  Kosuke Shigeta; Shigeru Kawakami; Yuriko Higuchi; Tatsuya Okuda; Hiroko Yagi; Fumiyoshi Yamashita; Mitsuru Hashida

  JOURNAL OF CONTROLLED RELEASE, Apr. 2007, Peer-reviewed

  
• The potential role of fucosylated cationic liposome/NF kappa B decoy complexes in the treatment of cytokine-related liver disease

  Yuriko Higuchi; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  BIOMATERIALS, Jan. 2007, Peer-reviewed

  
• INHIBITORY EFFECT OF MANNOSYLATED CATIONIC LIPOSOME/NF kappa DECOY COMPLEXES ON CYTOKINE PRODUCTION IN LPS-INDUCED SEPTIC PERITONITIS MOUSE MODEL

  Dinh Thuy Duong; Higuchi Yuriko; Kawakami Shigeru; Yamashita Fumiyoshi; Hashida Mitsuru

  DRUG METABOLISM REVIEWS, 2007, Peer-reviewed

  
• Pharmaceutical device of IFN

  Y. Higuchi; M. Hashida

  Nippon rinsho. Japanese journal of clinical medicine., Jul. 2006, Peer-reviewed

  
• Effect of the particle size of galactosylated lipoplex on hepatocyte-selective gene transfection after intraportal administration

  Yuriko Higuchi; Shigeru Kawakami; Shintaro Fumoto; Furniyoshi Yamashita; Mitsuru Hashida

  BIOLOGICAL & PHARMACEUTICAL BULLETIN, Jul. 2006, Peer-reviewed

  
• Intravenous administration of mannosylated cationic liposome/NF kappa B decoy complexes effectively prevent LPS-induced cytokine production in a murine liver failure model

  Y Higuchi; S Kawakami; M Oka; Y Yabe; F Yamashita; M Hashida

  FEBS LETTERS, Jun. 2006, Peer-reviewed

  
• Erratum: Intracellular distribution of NFκB decoy and its inhibitory effect on TNFα production by LPS stimulated RAW 264.7 cells (Journal of Controlled Release (2005) 107 (373-382) DOI: 10.1016/j.jconrel.2005.07.004)

  Yuriko Higuchi; Shigeru Kawakami; Makiya Nishikawa; Fumiyoshi Yamashita; Mitsuru Hashida

  Journal of Controlled Release, 10 Apr. 2006, Peer-reviewed

  
• Intracellular distribution of NF kappa B decoy and its inhibitory effect on TNF alpha production by LPS stimulated RAW 264.7 cells (vol 107, pg 373, 2005)

  Y Higuchi; S Kawakami; M Nishikawa; F Yamashita; M Hashida

  JOURNAL OF CONTROLLED RELEASE, Apr. 2006, Peer-reviewed

  
• Suppression of TNF alpha production in LPS induced liver failure in mice after intravenous injection of cationic liposomes/NF kappa B decoy complex

  Y Higuchi; S Kawakami; M Oka; F Yamashita; M Hashida

  PHARMAZIE, Feb. 2006, Peer-reviewed

  
• Interaction with blood components plays a crucial role in asialoglycoprotein receptor-mediated in vivo gene transfer by galactosylated lipoplex

  S Fumoto; S Kawakami; K Shigeta; Y Higuchi; F Yamashita; M Hashida

  JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Nov. 2005, Peer-reviewed

  
• Intracellular distribution of NF kappa B decoy and its inhibitory effect on TNF alpha production by LPS stimulated RAW 264.7 cells

  Y Higuchi; S Kawakami; M Nishikawa; F Yamashita; M Hashida

  JOURNAL OF CONTROLLED RELEASE, Oct. 2005, Peer-reviewed

  
• Biodistribution characteristics of mannosylated and fucosylated O/W emulsions in mice

  W Yeeprae; S Kawakami; Y Higuchi; F Yamashita; M Hashida

  JOURNAL OF DRUG TARGETING, Sep. 2005, Peer-reviewed

  
• Uptake characteristics of mannosylated and fucosylated bovine serum albumin in primary cultured rat sinusoidal endothelial cells and Kupffer cells

  Y Higuchi; M Nishikawa; S Kawakami; F Yamashita; M Hashida

  INTERNATIONAL JOURNAL OF PHARMACEUTICS, Dec. 2004, Peer-reviewed

  
• Effect of cationic charge on receptor-mediated transfection using mannosylated cationic liposome/plasmid DNA complexes following the intravenous administration in mice

  S. Kawakami; Y. Hattori; Y. Lu; Y. Higuchi; F. Yamashita; Mitsuru Hashida

  Pharmazie, May 2004, Peer-reviewed

  
• Involvement of serum mannan binding proteins and mannose receptors in uptake of mannosylated liposomes by macrophages

  P Opanasopit; Y Higuchi; S Kawakami; F Yamashita; M Nishikawa; M Hashida

  BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, Mar. 2001, Peer-reviewed

  

Misc.

• Increased gene and functional expression of P-glycoprotein in Caco-2 by streching stress stimulation

  高谷直樹; 津田真弘; 宗可奈子; 樋口ゆり子; 山下富義

  日本薬剤学会年会講演要旨集(CD-ROM), 2022

  
• ヒト肝臓癌細胞におけるレチノイドの増殖抑制効果

  八木 寛子; 川上 茂; 樋口 ゆり子; 山下 富義; 橋田 充

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 10 May 2007

  
• 抗原提示細胞指向型キャリアを用いたNFκBデコイ送達に基づくラット心移植急性拒絶におけるサイトカイン産生抑制

  樋口 ゆり子; 岩井 美栄子; 川上 茂; 山下 富義; 三原 潔; 谷川原 祐介; 橋田 充

  薬剤学 = Journal of Pharmaceutical Science and Technology, Japan, 10 May 2007

  
• Observation of Histidine-modified Chitosan/pDNA Complexes Escaping from Endosomes

  CHANG Kai-Ling; HIGUCHI Yuriko; KAWAKAMI Shigeru; YAMASHITA Fumiyoshi; HASHIDA Mitsuru

  バイオイメージング, 15 Jul. 2009

  
• 多機能性量子ドットによる細胞の体内動態追跡

  樋口 ゆり子; 橋田 充

  Drug delivery system, 09 Jun. 2009

  
• A memorial symposium : Professor Yutaka Mizushima・Professor Hitoshi Sezaki

  HIGUCHI Yuriko

  Drug delivery system, 23 Jan. 2009

  
• 量子ドット蛍光標識法による間葉系幹細胞の体内動態追跡

  呉 サン; 樋口 ゆり子; 川上 茂; 山下 富義; 橋田 充

  バイオイメージング, 30 Oct. 2008

  
• 量子ドットを用いた癌細胞腹膜播種における in vivo マクロファージ分布評価

  樋口 ゆり子; 岡 真千子; 川上 茂; 山下 富義; 橋田 充

  バイオイメージング, 30 Oct. 2008

  
• Sialyl LewisX mimic-decorated liposomes for anti-angiogenic everolimus delivery to E-selectin expressing endothelial cells

  Chanikarn Chantarasrivong; Yuriko Higuchi; Masahiro Tsuda; Yuuki Yamane; Mitsuru Hashida; Miku Konishi; Naoko Komura; Hiromune Ando; Fumiyoshi Yamashita

  RSC Advances, 01 Jan. 2019

  Access this misc :

  
• Fluorescent labeling reagent for cell membrane and organelles

  Yuriko Higuchi

  Drug Delivery System, 2017

  
• 凍結乾燥マンノース6リン修修飾バブルリポソームの開発

  安部 カヲル; 小田 雄介; 鈴木 亮; 小俣 大樹; Unga Johan; 宇留賀 仁史; 杉井 むつみ; 川上 茂; 樋口 ゆり子; 橋田 充; 丸山 一雄

  日本薬学会年会要旨集, Mar. 2015

  
• フッ化リン脂質を利用したバブルリポソームの開発

  小田 雄介; 高橋 秀依; 鈴木 亮; 小俣 大樹; Unga Johan; 宇留賀 仁史; 杉井 むつみ; 川上 茂; 樋口 ゆり子; 橋田 充; 丸山 一雄

  日本薬学会年会要旨集, Mar. 2015

  
• 任意の遺伝子を哺乳類ゲノムに組込み、安定発現させるための piggyBac トランスポゾン活用術

  中西秀之; 樋口ゆり子; 橋田充

  実験医学, Mar. 2015, Peer-reviewed, Invited

  
• 凍結乾燥バブルリポソームの開発と特性評価

  小田 雄介; 鈴木 亮; 小俣 大樹; 根岸 洋一; 川上 茂; 樋口 ゆり子; 橋田 充; 丸山 一雄

  日本薬学会年会要旨集, Mar. 2014

  
• バブルリポソームの安定性におよぼす脂質組成の影響

  小田雄介; 鈴木亮; 小俣大樹; 澤口能一; 根岸洋一; 川上茂; 樋口ゆり子; 橋田充; 丸山一雄

  日本DDS学会学術集会プログラム予稿集, 05 Jun. 2013

  
• フッ化リン脂質を用いたバブルリポソームの開発

  鬼塚沙也加; 小田雄介; 鈴木亮; 高橋秀依; 夏苅英昭; 川上茂; 樋口ゆり子; 橋田充; 丸山一雄

  遺伝子・デリバリー研究会シンポジウム要旨集, 11 May 2013

  
• マンノース修飾バブルリポプレックスを用いたNF‐κBデコイの腫瘍関連マクロファージへの導入に基づくphenotype制御

  河野裕允; 川上茂; 樋口ゆり子; 鈴木亮; 丸山一雄; 山下富義; 橋田充

  遺伝子・デリバリー研究会シンポジウム要旨集, 11 May 2013

  
• マンノース修飾バブルリポソームを用いたNF‐kappaB活性制御による腫瘍関連マクロファージのphenotype変化

  河野裕允; 川上茂; 樋口ゆり子; 鈴木亮; 丸山一雄; 山下富義; 橋田充

  日本薬剤学会年会講演要旨集(Web), 26 Apr. 2013

  
• In Vivo Real-Time Imaging of Cell Dynamics in Tissues of a Living Mouse by Confocal Microscope with the Suction Device

  Yuriko Higuchi; Yoshimasa Kozu; Shigeru Kawakami; Fumiyoshi Yamashita; Mitsuru Hashida

  MOLECULAR THERAPY, May 2012

  
• Photothermic regulation of gene expression triggered by laser-induced carbon nanohorns

  Eijiro Miyako; Tomonori Deguchi; Yoshihiro Nakajima; Masako Yudasaka; Yoshihisa Hagihara; Masanori Horie; Mototada Shichiri; Yuriko Higuchi; Fumiyoshi Yamashita; Mitsuru Hashida; Yasushi Shigeri; Yasukazu Yoshida; Sumio Iijima

  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, May 2012, Peer-reviewed

  
• 超音波応答性マンノース修飾リポソームを用いたsiRNA送達による抗炎症治療:siRNAの細胞内送達機構と抗炎症治療効果の評価

  運敬太; 川上茂; 樋口ゆり子; 鈴木亮; 丸山一雄; 山下富義; 橋田充

  アンチセンスシンポジウム講演要旨集, 01 Sep. 2011

  
• 明るい自動発光タンパク質を用いたバイオイメージング

  齊藤 健太; 張 郁芬; 堀川 一樹; 樋口 ゆり子; 木村 太郎; 永井 健治

  バイオイメージング, 10 Aug. 2011

  
• in vivo 蛍光イメージングによる幹細胞の体内挙動の可視化

  樋口 ゆり子; 橋田 充

  バイオイメージング, 10 Aug. 2011

  
• 超音波応答性マンノース修飾リポプレックスを用いたICAM‐1 siRNA送達による肝虚血再灌流性傷害の抑制

  運敬太; 川上茂; 吉田允; 樋口ゆり子; 鈴木亮; 丸山一雄; 山下富義; 橋田充

  Drug Deliv Syst, 28 May 2011

  
• 超音波応答性マンノース修飾リポプレックスによる遺伝子発現における転写過程の影響

  運敬太; 川上茂; 吉田允; 樋口ゆり子; 鈴木亮; 丸山一雄; 山下富義; 橋田充

  日本薬剤学会年会講演要旨集, 01 May 2011

  
• 超音波応答性マンノース修飾リポソームを用いたsiRNA送達システムによる新規抗炎症療法の開発

  運敬太; 川上茂; 樋口ゆり子; 鈴木亮; 丸山一雄; 山下富義; 橋田充

  Drug Deliv Syst, 28 May 2010

  
• 超音波応答性リポソームを用いたin‐vivo遺伝子導入法における転写因子活性化と炎症性サイトカイン産生の評価

  運敬太; 川上茂; 鈴木亮; 丸山一雄; 樋口ゆり子; 山下富義; 橋田充

  遺伝子・デリバリー研究会シンポジウム要旨集, 2010

  
• Oligonuleotide delivery with dendritic poly(L-lysine) for treatments of the liver disorders

  K. Watanabe; M. Harada-Shiba; A. Suzuki; Y. Higuchi; S. Kawakami; M. Hashida; R. Gokuden; R. Kurihara; Y. Sugao; T. Mori; Y. Katayama; T. Niidome

  Materials Research Society Symposium Proceedings, 2010, Peer-reviewed

  
• DEVELOPMENT OF MANNOSYLATED SEMICONDUCTOR QUANTUM DOTS FOR THE LABELING OF MACROPHAGES

  Yuriko Higuchi; Machiko Oka; Shigeru Kawakami; Mitsuru Hashida

  DRUG METABOLISM REVIEWS, 2007

  
• 肝臓非実質細胞培養系における糖修飾リガンドの取り込み特性の評価

  樋口 ゆり子; 兵頭 健治; 西川 元也; 山下 富義; 橋田 充

  薬剤学, 05 Mar. 2002

  

Industrial Property Rights

• 特願2016-096002, 生体観察用治具

  樋口ゆり子; 橋田充; 小西聡

  
• 特願2015-043050, 糖誘導体、またはその塩、セレクチン結合剤、糖結合体、粒子状キャリア、および輸送方法

  橋田充; 山下富義; 樋口ゆり子; チャニカーン; チャンタラスリウォン; 川上茂; ヨハン ウンガ; 木曽真; 植木章晴; 安藤弘宗

  
• 特表第5930364号, 特開2013-113976, 特願2011-259007, 生体試料固定器

  樋口ゆり子; 清水一憲; 小西聡; 橋田充

  
• 特願2011-68972, 自己会合によって均一な表面構造を形成するペプチドとカーボンナノチューブからなる複合炭素素材

  橋田泰彦; 橋田 充; 樋口ゆり子; 今堀博; 梅山有和; 磯田正二; 辻本将彦

  
• 特願2008-292740, 活性成分封入高分子ミセル及び活性成分の溶出制御方法

  横山昌幸; 佐藤 琢; 川上 茂; 樋口ゆり子; 橋田 充

  
• 特開2006-193488, 特願2005-008307, 免疫担当細胞指向型オリゴヌクレオチド・リポソーム複合体

  川上 茂; 橋田 充; 樋口ゆり子

  

Awards

• Jan. 2009

  日本薬学会近畿支部, 平成20年度日本薬学会近畿支部奨励賞
• 05 Jul. 2013

  日本DDS学会, 第5回日本DDS学会奨励賞
• 22 May 2015

  日本薬剤学会, 日本薬剤学会奨励賞

External funds: Kakenhi

• 細胞内抗原を標的としたin vivo抗体送達のための分子設計

  Grant-in-Aid for Scientific Research (A)

  Medium-sized Section 47:Pharmaceutical sciences and related fields

  Kyoto University

  二木 史朗

  From 05 Apr. 2021, To 31 Mar. 2024, Granted

  抗体;一本鎖抗体;細胞内送達

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21H04794/
• Muti-step targeted drug delivery to endoplasmic reticulum via retrograde transport systems

  Grant-in-Aid for Scientific Research (B)

  Basic Section 90120:Biomaterials-related

  Kyoto University

  Fumiyoshi Yamashita

  From 01 Apr. 2018, To 31 Mar. 2022, Project Closed

  ドラッグデリバリーシステム;細胞内標的指向化;糖鎖;小胞体;逆行性輸送;ドラッグデリバリー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H03531/
• Targeted delivery of cell medicine by cell surface modification with low molecular weight antibody

  Grant-in-Aid for Scientific Research (B)

  Basic Section 90110:Biomedical engineering-related

  Kyoto University

  Yuriko Higuchi

  From 01 Apr. 2018, To 31 Mar. 2022, Project Closed

  ドラッグデリバリー;間葉系幹細胞;低分子抗体;ドラッグデリバリーシステム;scFv

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H03516/
• Improvement of cell-selective adhesion by cell surface modification with low molecule antibody via PEG lipid

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Yuriko Higuchi

  From 01 Apr. 2016, To 31 Mar. 2018, Project Closed

  ドラッグデリバリー;低分子抗体;PEG脂質;間葉系幹細胞;血管内皮細胞;細胞製剤;ターゲティング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K15159/
• Development of safety evaluation system for DDS carrier based on network toxicology

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Mitsuru Hashida

  From 01 Apr. 2016, To 31 Mar. 2020, Project Closed

  安全性評価;DDS;薬物動態学;ドラッグデリバリーシステム

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16H01861/
• Cell surface modification using non-natural amino acid and its application to drug delivery system

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Mitsuru Hashida

  From 01 Apr. 2015, To 31 Mar. 2017, Project Closed

  細胞膜修飾;非天然アミノ酸;VHH;細胞接着;細胞製剤;ＤＤＳ;細胞治療;ドラッグデリバリー

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K14940/
• Innovation of chemiluminogenetics capable of noninvasive manipulation of biological functions deep inside body

  Grant-in-Aid for Scientific Research (A)

  Osaka University

  Takeharu Nagai

  From 01 Apr. 2014, To 31 Mar. 2017, Project Closed

  発光タンパク質;光感受性タンパク質;オプトジェネティクス;発光基質;ケミルミノジェネティクス;化学発光タンパク質

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26251018/
• Development the system controlling cell function based on the gene regulation via the ubiquitin proteasome pathway

  Grant-in-Aid for Young Scientists (A)

  Kyoto University

  Yuriko HIGUCHI

  From 01 Apr. 2013, To 31 Mar. 2016, Project Closed

  ユビキチンプロテアソーム経路;遺伝子発現制御;細胞製剤;ユビキチン‐プロテアソーム系;ユビキチンープロテアソーム経路

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25702028/
• Development of novel gene-switch system inducing inflammatory tissue-selective gene expression and realizing DDS for stem cell

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Mitsuru HASHIDA

  From 01 Apr. 2013, To 31 Mar. 2015, Project Closed

  遺伝子発現制御;炎症;幹細胞

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25670259/
• Development of cell surface modification with PEGylated lipid and external stimulation

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Yuriko HIGUCHI

  From 01 Apr. 2012, To 31 Mar. 2014, Project Closed

  幹細胞;PEG脂質;細胞膜表面修飾;超音波

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24650262/
• Long-term gene expression in primary cells by transposon and its application for cell therapy

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Mitsuru HASHIDA

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  ドラッグデリバリー;細胞治療;遺伝子発現長期化;トランスポゾン;細胞・遺伝子治療;遺伝子・細胞治療;長期発現

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659284/
• Development of heparin-based nanoparticles with multi-functional biological properties intended for rheumatoid arthritis therapy

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  Fumiyoshi YAMASHITA

  From 01 Apr. 2011, To 31 Mar. 2013, Project Closed

  ドラッグデリバリー;ヘパリンナノ粒子;関節リウマチ;マクロファージ;炎症性サイトカイン;TLR-4

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659022/
• Therapeutic strategy of drug delivery systems utilizing unique tumor environment

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Mitsuru HASHIDA

  From 01 Apr. 2011, To 31 Mar. 2014, Project Closed

  ドラッグデリバリー;核酸医療;がん治療;免疫活性化;小胞体ストレス;ナノバイオ材料;超音波医科学;がん微小環境;ナノ粒子;ターゲティング

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23240072/
• Development of a multifunctional quantum dot for in vivo tracing of fluorescent labeled cells

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  Yuriko HIGUCHI

  From 01 Apr. 2009, To 31 Mar. 2011, Project Closed

  量子ドット;幹細胞;イメージング;デンドリマー;エンドソーム脱出;PAMAMデンドリマー;分化;細胞内動態

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790035/
• トランスポゾンを用いたin vivo遺伝子発現長期化による新規慢性疾患療法の開発

  Grant-in-Aid for Challenging Exploratory Research

  Kyoto University

  橋田 充

  From 01 Apr. 2009, To 31 Mar. 2011, Project Closed

  トランスポゾン;プラスミドDNA;長期遺伝子発現;非ウイルス性キャリア;piggy Bacトランスポゾン;遺伝子発現長期化;ゲノムDNAへの組み込み;哺乳類;マウス

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21659008/
• 免疫細胞指向性ナノ粒子によるNFkB転写制御と移植拒絶抑制への応用

  Grant-in-Aid for Exploratory Research

  Kyoto University

  橋田 充

  From 01 Apr. 2007, To 31 Mar. 2009, Project Closed

  NFκB;デコイ;ターゲティング;遺伝子デリバリー;炎症性サイトカイン;リポソーム;マクロファージ;移植片拒絶

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19659037/
• 転写制御による炎症性疾患に対する新規治療法の開発

  Grant-in-Aid for Young Scientists (B)

  Kyoto University

  樋口 ゆり子

  From 01 Apr. 2006, To 31 Mar. 2008, Project Closed

  核酸医薬品;ターゲティング;炎症性疾患;NFκB;リポソーム;免疫担当細胞;デコイ;転写調製;遺伝子治療;転写調節

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18790117/
• Development of gene carriers based on in vivo and intracellular distribution real-time analysis

  Grant-in-Aid for Scientific Research (A)

  Kyoto University

  Hashida MITSURU

  From 01 Apr. 2006, To 31 Mar. 2009, Project Closed

  ドラッグデリバリー;遺伝子治療;遺伝子デリバリー;プラスミドDNA;サイトカイン;NFκB;エンドソーム;リポソーム;ポリマー;癌;ターゲティング;免疫応答;NFkB;カチオン性リポソーム;プロトンスボンジ効果;非ウィルス性キャリア

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18209006/
• 低分子抗体を用いた幹細胞デリバリーによる肝線維化治療

  Grant-in-Aid for Scientific Research (B)

  Basic Section 90110:Biomedical engineering-related

  Kyoto University

  樋口 ゆり子

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  ドラッグデリバリー;間葉系幹細胞;肝線維化治療;ドラッグデリバリーシステム;低分子抗体;肝炎

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22H03940/
• 集積回路への細胞固定による生体反応の制御と検出

  Grant-in-Aid for Challenging Research (Exploratory)

  Medium-sized Section 90:Biomedical engineering and related fields

  Kyoto University

  樋口 ゆり子

  From 30 Jun. 2022, To 31 Mar. 2024, Granted

  細胞;集積回路;クリック反応

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22K19917/
• 低分子抗体を用いた幹細胞デリバリーによる肝線維化治療

  Grant-in-Aid for Scientific Research (B)

  Basic Section 90110:Biomedical engineering-related

  Kyoto University

  樋口 ゆり子

  From 01 Apr. 2022, To 31 Mar. 2026, Granted

  ドラッグデリバリー;間葉系幹細胞;肝線維化治療;ドラッグデリバリーシステム;低分子抗体;肝炎

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23K25194/
• Understanding the molecular and cellular basis and controlling cellular phenomena: A New Concept for Intracellular Delivery of Antibodies

  Grant-in-Aid for Scientific Research (S)

  Broad Section E

  Kyoto University

  二木 史朗

  From 01 Apr. 2024, To 31 Mar. 2029, Granted

  ペプチド;抗体;細胞内送達;細胞膜透過性;細胞機能制御

  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24H00051/

External funds: others

• 新規多機能性キトサンによる遺伝子導入システムの開発とDNAワクチンへの応用

  平成21年度厚生労働科学研究費補助金政策創薬総合研究事業　若手研究者奨励研究

  From 2009, To 2011

  樋口ゆり子
• 蛍光イメージングによる幹細胞挙動解析法の創成

  戦略的創造研究推進事業 さきがけ

  From 2009, To 2013

  樋口ゆり子

Education

Teaching subject(s)

• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Sciences and Ethics

  U129, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Practice in Pharmaceutical Sciences II

  6304, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Practice in Pharmaceutical Sciences I

  6303, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  4207, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Physical Chemistry for Drug Discovery A

  8201, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Pharmacy and Biomedical Sciences for Drug Discovery

  8208, Fall, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Pharmaceutical Biochemistry B

  8206, Spring, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Organic Chemistry for Drug Discovery B

  8204, Fall, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Clinical Pharmacy

  8216, Fall, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  Biological Medicinal Formulations

  C316, Spring, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2024, To 31 Mar. 2025

  共用試験関係

  B999, Year-long, Faculty of Pharmaceutical Sciences, 0
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Laboratory Techniques in Pharmaceutical Sciences

  8401, Spring, Graduate School of Pharmaceutical Sciences, 0.5
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Training(Biopharmaceutics and Drug Metabolism)

  E814, Year-long, Faculty of Pharmaceutical Sciences, 14
• From 01 Apr. 2024, To 31 Mar. 2025

  Research Training(DrugDeliveryResearch)

  D176, Year-long, Faculty of Pharmaceutical Sciences, 10
• From 01 Apr. 2024, To 31 Mar. 2025

  Medicinal Pharmacy 3 (Biopharmaceutics)

  A312, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutics 2 (Solid formulations)

  A311, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmacopoeia ; Pharmaceutical Laws

  C315, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutics II (Pharmacokinetics)

  C312, Fall, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmacopoeia ; Pharmaceutical Laws

  A315, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Pharmaceutical Laboratory III : Pharmaceutics and Pharmacology

  C905, Fall, Faculty of Pharmaceutical Sciences, 3
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Modern Life Sciences for Drug Discovery

  1027, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Organic Chemistry for Drug Discovery

  1026, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  1208, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  1208, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  1028, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Basic Organic Chemistry II

  1210, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Pharmaceutical Sciences I

  6005, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Clinical Pharmacy

  6004, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Laboratory Techniques in Pharmaceutical Sciences

  6003, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar for Clinical Pharmacy II

  6102, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar for Clinical Pharmacy I

  6101, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Pharmaceutical Sciences III

  6007, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Basic Pharmacy and Biomedicinal Sciences I

  1215, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Basic Biological Chemistry II

  1214, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Advanced Basic Physical Chemistry I

  1211, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Sciences

  6002, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Basic Pharmacology and Drug Delivery Research Seminar

  2307, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Physical Chemistry for Drug Discovery

  1217, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Physical Chemistry for Drug Discovery

  8101, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Seminar for Clinical Pharmacy III

  6103, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmacy and Biomedical Sciences for Drug Discovery

  8105, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Pharmaceutical Biochemistry

  8103, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Introduction to Organic Chemistry for Drug Discovery

  8102, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Pharmaceutical Sciences I

  6201, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Basic Pharmacology and Drug Delivery

  3207, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Pharmaceutical Sciences III

  6203, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2024, To 31 Mar. 2025

  Research in Pharmaceutical Sciences II

  6202, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Introduction to Pharmaceutical Sciences and Ethics

  U129, Spring, Institute for Liberal Arts and Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Pharmaceutical Sciences II

  6304, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Pharmaceutical Sciences I

  6303, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  4207, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Biological Medicinal Formulations

  C316, Spring, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Pharmaceutical Sciences

  8401, Spring, Graduate School of Pharmaceutical Sciences, 0.5
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory III : Pharmaceutics and Pharmacology

  C905, Fall, Faculty of Pharmaceutical Sciences, 3
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Basic Pharmacology and Drug Delivery

  3207, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Pharmaceutical Sciences I

  6201, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Pharmaceutical Sciences III

  6203, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Research in Pharmaceutical Sciences II

  6202, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  A905, Fall, Faculty of Pharmaceutical Sciences, 4
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Pharmaceutical Sciences

  6003, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Pharmacology and Drug Delivery Research Seminar

  2307, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  1208, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar for Clinical Pharmacy III

  6103, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar for Clinical Pharmacy II

  6102, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Seminar for Clinical Pharmacy I

  6101, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  1208, Fall, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmacopoeia ; Pharmaceutical Laws

  A315, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmaceutics 2 (Solid formulations)

  A311, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2023, To 31 Mar. 2024

  Pharmacopoeia ; Pharmaceutical Laws

  C315, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Basic Pharmacology and Drug Delivery

  3207, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Pharmacology and Drug Delivery Research Seminar

  2307, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutics 2 (Solid formulations)

  A311, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmacopoeia ; Pharmaceutical Laws

  A315, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar for Clinical Pharmacy III

  6103, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  1208, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Practice in Pharmaceutical Sciences II

  6304, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  A905, Fall, Faculty of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Laboratory Techniques in Pharmaceutical Sciences

  8401, Spring, Graduate School of Pharmaceutical Sciences, 0.5
• From 01 Apr. 2022, To 31 Mar. 2023

  Basic Laboratory Techniques in Pharmaceutical Sciences

  6003, Spring, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical Laboratory III : Pharmaceutics and Pharmacology

  C905, Fall, Faculty of Pharmaceutical Sciences, 3
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical R&D Exercise 1

  C404, Spring, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Practice in Pharmaceutical Sciences I

  6303, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmacopoeia ; Pharmaceutical Laws

  C315, Spring, Faculty of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Biological Medicinal Formulations

  C316, Spring, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Pharmaceutical R&D Exercise I

  A404, Spring, Faculty of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Pharmaceutical Sciences III

  6203, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar for Clinical Pharmacy I

  6101, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Pharmaceutical Sciences II

  6202, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Research in Pharmaceutical Sciences I

  6201, Year-long, Graduate School of Pharmaceutical Sciences, 4
• From 01 Apr. 2022, To 31 Mar. 2023

  Seminar for Clinical Pharmacy II

  6102, Year-long, Graduate School of Pharmaceutical Sciences, 2
• From 01 Apr. 2022, To 31 Mar. 2023

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  4207, Year-long, Graduate School of Pharmaceutical Sciences, 1
• From 01 Apr. 2022, To 31 Mar. 2023

  ２１ＣＯＥ化学講義３（理）

  8001, Spring, Graduate School of Pharmaceutical Sciences, 2
• From Apr. 2014, To Mar. 2015

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2014, To Mar. 2015

  Pre-Training for Clinical Clerkship

  Year-long, 薬学部
• From Apr. 2014, To Mar. 2015

  Biopharmaceutics

  Fall, 医学研究科
• From Apr. 2015, To Mar. 2016

  Pre-Training for Clinical Clerkship

  Year-long, 薬学部
• From Apr. 2015, To Mar. 2016

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2015, To Mar. 2016

  Biopharmaceutics

  Fall, 医学研究科
• From Apr. 2016, To Mar. 2017

  Pre-Training for Clinical Clerkship

  Year-long, 薬学部
• From Apr. 2016, To Mar. 2017

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2016, To Mar. 2017

  Biopharmaceutics

  Fall, 工学研究科
• From Apr. 2016, To Mar. 2017

  Biopharmaceutics

  Fall, 医学研究科
• From Apr. 2017, To Mar. 2018

  Pre-Training for Clinical Clerkship

  Year-long, 薬学部
• From Apr. 2017, To Mar. 2018

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Fall, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Seminar for Clinical Pharmacy III

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Seminar for Clinical Pharmacy II

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Seminar for Clinical Pharmacy I

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2017, To Mar. 2018

  Laboratory Practice in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Laboratory Practice in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Pharmaceutical Sciences III

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Research in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2017, To Mar. 2018

  Pharmacopoeia ; Pharmaceutical Laws

  Spring, 薬学部
• From Apr. 2017, To Mar. 2018

  Biopharmaceutics

  Fall, 工学研究科
• From Apr. 2017, To Mar. 2018

  Biopharmaceutics (LIMS)

  Fall, 医学研究科
• From Apr. 2018, To Mar. 2019

  Pharmaceutical R&D Exercise I

  Spring, 薬学部
• From Apr. 2018, To Mar. 2019

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Fall, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Seminar for Clinical Pharmacy III

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Seminar for Clinical Pharmacy II

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Seminar for Clinical Pharmacy I

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Fall, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2018, To Mar. 2019

  Laboratory Practice in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory Practice in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory Practice in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Laboratory Practice in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Pharmaceutical Sciences III

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Research in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2018, To Mar. 2019

  Pharmacopoeia ; Pharmaceutical Laws

  Spring, 薬学部
• From Apr. 2018, To Mar. 2019

  Biopharmaceutics

  Fall, 工学研究科
• From Apr. 2018, To Mar. 2019

  Biopharmaceutics (LIMS)

  Fall, 医学研究科
• From Apr. 2019, To Mar. 2020

  ILAS Seminar

  Spring, 全学共通科目
• From Apr. 2019, To Mar. 2020

  Pharmaceutical R&D Exercise I

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Basic Pharmacology and Drug Delivery

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Basic Pharmacology and Drug Delivery

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Pharmacology and Drug Delivery Research Seminar

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Pharmacology and Drug Delivery Research Seminar

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Seminar for Clinical Pharmacy III

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Seminar for Clinical Pharmacy II

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Seminar for Clinical Pharmacy I

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Pharmaceutical Sciences II

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Laboratory Practice in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Pharmaceutical Sciences III

  Fall, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Pharmaceutical Sciences III

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Pharmaceutical Sciences II

  Spring, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Research in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2019, To Mar. 2020

  Pharmacopoeia ; Pharmaceutical Laws

  Spring, 薬学部
• From Apr. 2019, To Mar. 2020

  Biopharmaceutics (LIMS)

  Fall, 医学研究科
• From Apr. 2020, To Mar. 2021

  Pharmaceutical R&D Exercise 1

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Pharmaceutical R&D Exercise I

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Basic Pharmacology and Drug Delivery

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Basic Pharmacology and Drug Delivery

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Pharmacology and Drug Delivery Research Seminar

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Pharmacology and Drug Delivery Research Seminar

  Fall, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Fundamental Chemical Experiments

  Fall, 全学共通科目
• From Apr. 2020, To Mar. 2021

  Seminar for Clinical Pharmacy III

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Seminar for Clinical Pharmacy II

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Seminar for Clinical Pharmacy I

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Pharmaceutical Laboratory III : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Pharmaceutical Sciences II

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Laboratory Practice in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Pharmaceutical Sciences III

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Pharmaceutical Sciences III

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Pharmaceutical Sciences II

  Spring, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Research in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2020, To Mar. 2021

  Pharmacopoeia ; Pharmaceutical Laws

  Spring, 薬学部
• From Apr. 2020, To Mar. 2021

  Biopharmaceutics (LIMS)

  Fall, 医学研究科
• From Apr. 2021, To Mar. 2022

  Pharmaceutical R&D Exercise 1

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Pharmaceutical R&D Exercise I

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Biological Medicinal Formulations

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Pharmacy and Biomedicinal Sciences

  Fall, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Laboratory Practice in Basic Pharmacodynamic and Pharmacological Sciences

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Basic Pharmacology and Drug Delivery

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Pharmacology and Drug Delivery Research Seminar

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Seminar for Clinical Pharmacy III

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Seminar for Clinical Pharmacy II

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Seminar for Clinical Pharmacy I

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Pharmaceutics 2 (Solid formulations)

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Basic Laboratory Techniques in Pharmaceutical Sciences

  Spring, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Pharmaceutical Laboratory III : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Pharmaceutical Laboratory 3 : Pharmaceutics and Pharmacology

  Fall, 薬学部
• From Apr. 2021, To Mar. 2022

  Laboratory Practice in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Laboratory Practice in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Pharmaceutical Sciences III

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Pharmaceutical Sciences II

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Research in Pharmaceutical Sciences I

  Year-long, 薬学研究科
• From Apr. 2021, To Mar. 2022

  Pharmacopoeia ; Pharmaceutical Laws

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Pharmacopoeia ; Pharmaceutical Laws

  Spring, 薬学部
• From Apr. 2021, To Mar. 2022

  Biopharmaceutics (LIMS)

  Fall, 医学研究科

Participation in PhD Defense

• Study on formulation to improve pharmacokinetics of extracellular vesicles based on their physicochemical properties

  KOBAYASHI YUKI, Graduate School of Pharmaceutical Sciences, Chief Examiner

  25 Mar. 2024
• がんのオージェ治療および光線力学療法の併用を可能にする二機能性薬剤の開発に関する研究

  ONOUE RYOTARO, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  25 Mar. 2024
• Studies on the anticancer effect of bisabosqual A, as a novel asparagine synthetase inhibitor, in human non-small cell lung cancer cells

  Yanjun Pan, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  25 Mar. 2024
• Programmed cell-immobilization of living cells by independent molecular interaction

  ZHU CHENGYUAN, Graduate School of Pharmaceutical Sciences, Chief Examiner

  25 Mar. 2024
• がんのセラノスティクスに資する3官能性放射性薬剤の開発に関する研究

  NAKASHIMA KAZUMA, Graduate School of Pharmaceutical Sciences, Sub-chief Examiner

  25 Mar. 2024

Administration

School management (title, position)

• From 01 Apr. 2025, To 31 Mar. 2027

  人権委員会 委員

Faculty management (title, position)

• From 01 Apr. 2024, To 31 Mar. 2025

  情報システム委員会　委員
• From 01 Apr. 2024, To 31 Mar. 2025

  教務委員会　委員
• From 01 Apr. 2024, To 31 Mar. 2025

  統合薬学教育開発センター運営委員会　委員
• From 01 Apr. 2024, To 31 Mar. 2025

  産学共同講座「ナノバイオ医薬創成科学講座」運営委員
• From 01 Apr. 2022, To 31 Mar. 2024

  DEI推進委員会　委員
• From 01 Apr. 2024, To 31 Mar. 2025

  将来計画委員会　委員
• From 01 Apr. 2024, To 31 Mar. 2025

  DEI推進委員会　委員長
• From 01 Apr. 2022, To 31 Mar. 2024

  DEI推進委員会　委員
• From 01 Apr. 2017, To 31 Mar. 2024

  図書委員会　委員
• From 01 Apr. 2017, To 31 Mar. 2024

  環境・安全衛生委員会　委員
• From 01 Apr. 2019, To 31 Mar. 2025

  人権委員会 委員
• From 01 Apr. 2019, To 31 Mar. 2024

  ハラスメント相談窓口
• From 01 Apr. 2020, To 31 Mar. 2024

  ホームページ広報委員会　委員
• From 01 Apr. 2017, To 31 Mar. 2020

  動物実験委員会　委員